Affinage

MAT1A

S-adenosylmethionine synthase isoform type-1 · UniProt Q00266

Length
395 aa
Mass
43.6 kDa
Annotated
2026-06-10
100 papers in source corpus 7 papers cited in narrative 7 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 3/4 claims corpus-supported (75%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MAT1A encodes the catalytic subunit of methionine adenosyltransferase I/III, the enzyme that synthesizes S-adenosylmethionine (SAM) and thereby governs hepatic one-carbon metabolism (PMID:11278456). The dominant R264H mutation produces a monomeric subunit retaining tripolyphosphatase activity but only ~0.37% of normal AdoMet synthetic activity; because the mutant subunit associates with wild-type subunits into catalytically inactive heterodimers, it acts dominantly to abolish AdoMet synthesis, explaining dominant hypermethioninemia (PMID:11278456). MAT1A expression is controlled at multiple post-transcriptional and epigenetic levels: the RNA-binding protein AUF1 destabilizes MAT1A mRNA during hepatic de-differentiation and carcinogenesis, with SAM itself shifting the AUF1/methyl-HuR balance (PMID:20102719); miR-22, miR-29b, and miR-143 repress MAT1A, the latter forming a betaine–miR-143–MAT1A axis that tunes hepatic SAM levels (PMID:22213190, PMID:35734958); and a CTBP1/HDAC1/HDAC2 repressor complex silences MAT1A transcription in hepatocellular carcinoma, where restoring MAT1A and raising SAM promotes ferroptosis and enhances CD8+ T-cell cytotoxicity (PMID:37230466). In cancer contexts MAT1A also exerts a non-canonical role, stabilizing CCND1 against SKP2-mediated ubiquitination to drive glycolysis and proliferation in NSCLC (PMID:39438468).

Mechanistic history

Synthesis pass · year-by-year structured walk · 7 steps
  1. 2001 High

    Established the molecular basis of dominantly inherited hypermethioninemia by showing how a single MAT1A mutation abolishes SAM synthesis even in the presence of wild-type subunits.

    Evidence In vitro enzymatic assays of recombinant R264H/R265H mutant MAT plus in vivo co-expression demonstrating inactive heterodimer formation

    PMID:11278456

    Open questions at the time
    • Does not resolve the structural basis of why the monomeric mutant retains tripolyphosphatase but loses AdoMet synthesis
    • No in vivo demonstration of the heterodimer poisoning effect in patient liver
  2. 2010 Medium

    Identified post-transcriptional control of MAT1A by linking AUF1-mediated mRNA destabilization to the loss of MAT1A during liver de-differentiation and carcinogenesis.

    Evidence AUF1 binding site identification, mRNA stability assays, and immunofluorescence in hepatic de-differentiation and HCC models

    PMID:20102719

    Open questions at the time
    • Direct AUF1–MAT1A 3'UTR binding partly in silico
    • Mechanism by which SAM shifts the AUF1/methyl-HuR balance not fully defined
    • Single-lab data
  3. 2011 Medium

    Showed that MAT1A silencing in early hepatocarcinogenesis is driven by combined epigenetic chromatin changes and microRNA repression.

    Evidence ChIP for H3K27me3/H3K18ac at the Mat1a promoter and miR-22/miR-29b functional studies in a rat 2-AAF hepatocarcinogenesis model

    PMID:22213190

    Open questions at the time
    • Single carcinogen model in rat
    • Direct miRNA–MAT1A target binding not validated by reporter assay in this study
    • Relative contributions of chromatin vs miRNA repression unquantified
  4. 2022 Medium

    Defined a dietary-to-metabolic regulatory axis showing miR-143 directly represses MAT1A and that betaine raises hepatic SAM by de-repressing it.

    Evidence miR-143 knockout mice, betaine supplementation, luciferase reporter target validation, and SAM measurements

    PMID:35734958

    Open questions at the time
    • Physiological context limited to dietary betaine
    • Single-lab data
    • Downstream consequences of altered SAM not characterized
  5. 2023 Medium

    Connected transcriptional repression of MAT1A to tumor immunometabolism, showing a CTBP1/HDAC1/HDAC2 complex silences MAT1A and that restoring it promotes ferroptosis and antitumor immunity.

    Evidence Co-IP of CTBP1/HDAC1/HDAC2, siRNA knockdown, MAT1A overexpression, SAM measurement, and xenografts with ferrostatin-1

    PMID:37230466

    Open questions at the time
    • Mechanism linking SAM elevation to ferroptosis not detailed
    • Single-lab data
    • Direct CTBP1 occupancy at the MAT1A promoter not shown
  6. 2024 Medium

    Revealed a non-canonical, extra-hepatic role for MAT1A as a protein stabilizer driving cancer metabolism beyond its SAM-synthesizing function.

    Evidence Stable MAT1A knockdown in NSCLC cells, MAT1A–CCND1 co-IP, SKP2-mediated CCND1 ubiquitination assays, and glycolysis measurements

    PMID:39438468

    Open questions at the time
    • Whether the CCND1-stabilizing role depends on MAT1A catalytic activity unknown
    • Direct MAT1A–CCND1 binding interface not mapped
    • Single-lab data
  7. 2019 Low

    Observed that MAT1A overexpression confers chemotolerance via growth arrest, hinting at a role in cancer cell persistence.

    Evidence MAT1A overexpression in 5637 bladder cancer cells with gemcitabine dose-response and patient-derived xenograft RNA-seq

    PMID:31600961

    Open questions at the time
    • No pathway mechanism identified linking MAT1A to quiescence or drug tolerance
    • Single overexpression experiment
    • No in vivo validation of the quiescence model

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved whether MAT1A's non-canonical protein-stabilizing and chemotolerance roles depend on its SAM-synthesizing activity, and how its multilayered repression integrates across tissues.
  • Catalytic dependence of CCND1 stabilization untested
  • No unified model connecting AUF1, miRNA, and CTBP1/HDAC repression
  • Structural model of the catalytic enzyme absent from this corpus

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 1 GO:0140096 catalytic activity, acting on a protein 1
Pathway
R-HSA-1430728 Metabolism 2
Partners
AUF1CCND1SKP2

Evidence

Reading pass · 7 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 The dominant R264H mutation in MAT1A (human MAT I/III) produces a monomeric enzyme with only 0.37% of normal AdoMet synthetic activity but retains tripolyphosphatase activity. The mutant R264H subunit associates with wild-type subunits to form a catalytically inactive heterodimer unable to synthesize AdoMet, providing the molecular mechanism for dominant inheritance of hypermethioninemia. In vitro enzymatic assay of recombinant mutant MAT (rat R265H equivalent), in vivo co-expression studies demonstrating heterodimer formation, activity measurements for AdoMet synthesis and tripolyphosphatase activity The Journal of biological chemistry High 11278456
2010 MAT1A mRNA stability is regulated post-transcriptionally by the RNA-binding protein AUF1, which destabilizes MAT1A mRNA. During hepatic de-differentiation and liver carcinogenesis, increased AUF1 expression coincides with decreased MAT1A expression. S-adenosylmethionine treatment shifts the balance of AUF1 and methyl-HuR/HuR, modulating MAT1A mRNA stability. RNA-binding protein binding assays (in silico identification of AUF1 binding sites in MAT1A 3'UTR), functional studies in hepatic de-differentiation models, immunofluorescence, mRNA stability assays Gastroenterology Medium 20102719
2011 Downregulation of Mat1a in early rat hepatocarcinogenesis is associated with increased histone H3 lysine 27 trimethylation and decreased histone H3 lysine 18 acetylation at the Mat1a promoter/first exon. Additionally, miR-22 and miR-29b directly contribute to inhibition of Mat1a expression during 2-acetylaminofluorene-induced hepatocarcinogenesis. Chromatin immunoprecipitation (ChIP) for histone modifications at Mat1a promoter, microRNA expression profiling and functional studies in rat hepatocarcinogenesis model Molecular carcinogenesis Medium 22213190
2023 The CTBP1/HDAC1/HDAC2 transcriptional repressor complex suppresses MAT1A transcription in hepatocellular carcinoma. CTBP1 interacts with HDAC1 and HDAC2, and silencing of either HDAC1 or HDAC2 restores MAT1A expression. MAT1A overexpression increases S-adenosylmethionine levels, which promotes ferroptosis of HCC cells and enhances CD8+ T-cell cytotoxicity and interferon-γ production. Co-immunoprecipitation of CTBP1/HDAC1/HDAC2 complex, siRNA knockdown of HDAC1/HDAC2, MAT1A overexpression in cell lines, SAM level measurement, in vivo xenograft experiments with ferrostatin-1 treatment Laboratory investigation; a journal of technical methods and pathology Medium 37230466
2022 miR-143 targets MAT1a mRNA, and betaine supplementation down-regulates miR-143, which subsequently increases SAM levels in the liver by de-repressing MAT1a. This identifies a betaine-miR-143-MAT1a regulatory axis in hepatic one-carbon metabolism. miR-143 knockout mice, betaine supplementation experiments, luciferase reporter assay and expression analysis confirming MAT1a as miR-143 target, SAM level measurement Journal of agricultural and food chemistry Medium 35734958
2024 MAT1A promotes NSCLC progression by stabilizing CCND1 protein; MAT1A depletion accelerates CCND1 degradation via SKP2-mediated ubiquitination. CCND1 acts as a MAT1A partner to jointly regulate glycolytic metabolism in NSCLC cells. Stable MAT1A knockdown in NSCLC cell lines, proliferation/migration/apoptosis assays, co-immunoprecipitation of MAT1A and CCND1, ubiquitination assays showing SKP2-mediated CCND1 degradation upon MAT1A depletion, glycolysis measurements Cell death & disease Medium 39438468
2019 MAT1A overexpression in bladder cancer cells increases tolerance to gemcitabine and stalls cell proliferation, suggesting MAT1A upregulation enables cancer cells to persist in a quiescent state to evade chemotherapy. MAT1A overexpression in 5637 bladder cancer cell line, gemcitabine dose-response assays, cell proliferation measurements, RNA-sequencing of patient-derived xenograft tumors before and after cisplatin/gemcitabine treatment International journal of molecular sciences Low 31600961

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Mating-type genes and MAT switching in Saccharomyces cerevisiae. Genetics 304 22555442
2006 Unexpected diversity and complexity of the Guerrero Negro hypersaline microbial mat. Applied and environmental microbiology 287 16672518
1995 Crystal structure of the MATa1/MAT alpha 2 homeodomain heterodimer bound to DNA. Science (New York, N.Y.) 234 7569974
2011 Radical-mediated enzymatic methylation: a tale of two SAMS. Accounts of chemical research 184 22097883
1998 Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway. Cell 170 9695950
2004 Evolution of the MAT locus and its Ho endonuclease in yeast species. Proceedings of the National Academy of Sciences of the United States of America 166 14745027
2000 Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans. The Journal of cell biology 144 11134076
1995 Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes. The Journal of biological chemistry 138 7836447
1984 The yeast MATa1 gene contains two introns. The EMBO journal 124 6329735
1992 IME4, a gene that mediates MAT and nutritional control of meiosis in Saccharomyces cerevisiae. Molecular and cellular biology 120 1545790
2010 HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology 115 20102719
2009 Bacterial, archaeal and eukaryotic diversity of smooth and pustular microbial mat communities in the hypersaline lagoon of Shark Bay. Geobiology 95 19200148
2011 Knockdown of SAMS genes encoding S-adenosyl-l-methionine synthetases causes methylation alterations of DNAs and histones and leads to late flowering in rice. Journal of plant physiology 78 21757254
2017 A viral protein promotes host SAMS1 activity and ethylene production for the benefit of virus infection. eLife 74 28994391
2000 Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). The Journal of biological chemistry 69 10644686
2013 The MAT locus genes play different roles in sexual reproduction and pathogenesis in Fusarium graminearum. PloS one 68 23826182
2010 Isolation and characterization of MAT genes in the symbiotic ascomycete Tuber melanosporum. The New phytologist 68 20961294
2012 Within-mat variability in anatoxin-a and homoanatoxin-a production among benthic Phormidium (cyanobacteria) strains. Toxins 61 23162704
2008 Diversity and stratification of archaea in a hypersaline microbial mat. Applied and environmental microbiology 61 19114531
1998 Characterization of mat A-2, mat A-3 and deltamatA mating-type mutants of Neurospora crassa. Genetics 60 9539425
2015 P-SAMS: a web site for plant artificial microRNA and synthetic trans-acting small interfering RNA design. Bioinformatics (Oxford, England) 59 26382195
2009 Organization and evolutionary trajectory of the mating type (MAT) locus in dermatophyte and dimorphic fungal pathogens. Eukaryotic cell 58 19880755
1986 Identification of the DNA sequences controlling the expression of the MAT alpha locus of yeast. Proceedings of the National Academy of Sciences of the United States of America 56 3517864
2015 Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer. Nature communications 55 25925782
2022 Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA. Signal transduction and targeted therapy 53 35729157
2007 Mat formation in Saccharomyces cerevisiae requires nutrient and pH gradients. Eukaryotic cell 51 17951523
1991 The role of RAP1 in the regulation of the MAT alpha locus. Molecular and cellular biology 51 1990267
2014 Immune regulation by intralymphatic immunotherapy with modular allergen translocation MAT vaccine. Allergy 46 24934402
1997 Energetics of folding and DNA binding of the MAT alpha 2 homeodomain. Biochemistry 44 9012668
1994 Heterodimerization of the yeast MATa1 and MAT alpha 2 proteins is mediated by two leucine zipper-like coiled-coil motifs. The EMBO journal 43 8137824
2012 The response regulator RcsB activates expression of Mat fimbriae in meningitic Escherichia coli. Journal of bacteriology 41 22522901
2011 Contribution of sams-1 and pmt-1 to lipid homoeostasis in adult Caenorhabditis elegans. Journal of biochemistry 40 21389045
2011 Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene. Molecular carcinogenesis 39 22213190
1998 Crystal structure of the MATa1/MATalpha2 homeodomain heterodimer in complex with DNA containing an A-tract. Nucleic acids research 37 9838003
2009 Spatial and temporal variability in a stratified hypersaline microbial mat community. FEMS microbiology ecology 36 19175677
2003 Insights into binding cooperativity of MATa1/MATalpha2 from the crystal structure of a MATa1 homeodomain-maltose binding protein chimera. Protein science : a publication of the Protein Society 36 12538894
2002 maT--a clade of transposons intermediate between mariner and Tc1. Molecular biology and evolution 34 12446802
2008 Lipid biomarker and phylogenetic analyses to reveal archaeal biodiversity and distribution in hypersaline microbial mat and underlying sediment. Geobiology 30 18564188
2008 Hypermethioninaemia due to methionine adenosyltransferase I/III (MAT I/III) deficiency: diagnosis in an expanded neonatal screening programme. Journal of inherited metabolic disease 29 18500573
2013 MAT gene idiomorphs suggest a heterothallic sexual cycle in a predominantly asexual and important pine pathogen. Fungal genetics and biology : FG & B 28 24220137
2011 Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation. Nucleic acids research 28 22021379
2006 Modulating cell adhesion and spreading by control of FnIII7-10 orientation on charged self-assembled monolayers (SAMs) of alkanethiolates. Journal of biomedical materials research. Part A 28 16514600
2010 Mat fimbriae promote biofilm formation by meningitis-associated Escherichia coli. Microbiology (Reading, England) 27 20522494
1981 The mat-1 gene in Chlamydomonas regulates DNA methylation during gametogenesis. Cell 27 6263491
2022 SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity. Autophagy 26 35503435
2006 Structural and functional properties of two human FXYD3 (Mat-8) isoforms. The Journal of biological chemistry 26 17077088
2001 Biochemical basis for the dominant inheritance of hypermethioninemia associated with the R264H mutation of the MAT1A gene. A monomeric methionine adenosyltransferase with tripolyphosphatase activity. The Journal of biological chemistry 25 11278456
1999 A novel role for the mating type (MAT) locus in the maintenance of cell wall integrity in Saccharomyces cerevisiae. Molecular & general genetics : MGG 25 10394905
2023 Protein translocation in mitochondria: Sorting out the Toms, Tims, Pams, Sams and Mia. FEBS letters 24 37021373
2020 Combined PCR and MAT improves the early diagnosis of the biphasic illness leptospirosis. PloS one 24 32915919
2014 Unraveling the stratification of an iron-oxidizing microbial mat by metatranscriptomics. PloS one 24 25033299
1991 MAT alpha 1 can mediate gene activation by a-mating factor. Genes & development 24 1916267
2017 Comparison of the active and resident community of a coastal microbial mat. Scientific reports 23 28592823
2020 Sphinganine-Analog Mycotoxins (SAMs): Chemical Structures, Bioactivities, and Genetic Controls. Journal of fungi (Basel, Switzerland) 22 33255427
2017 Preparation and Characterization of Protein-Loaded Electrospun Fiber Mat and Its Release Kinetics. Journal of agricultural and food chemistry 22 28535347
2013 Phylogenetic group-associated differences in regulation of the common colonization factor Mat fimbria in Escherichia coli. Molecular microbiology 22 23347101
2003 Isolation and characterisation of the mating-type (MAT) locus from Rhynchosporium secalis. Current genetics 22 14517690
2024 Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and vice versa. Chemical Society reviews 21 38456490
2010 MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate. The American journal of clinical nutrition 21 20335551
2010 Chemical and physical environmental conditions underneath mat- and canopy-forming macroalgae, and their effects on understorey corals. PloS one 21 20856882
2004 Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis. Carcinogenesis 21 15498786
2022 miR-143-Mediated Responses to Betaine Supplement Repress Lipogenesis and Hepatic Gluconeogenesis by Targeting MAT1a and MAPK11. Journal of agricultural and food chemistry 20 35734958
2012 Regulation of mat responses by a differentiation MAPK pathway in Saccharomyces cerevisiae. PloS one 20 22496730
2008 Multifunctional mixed SAMs that promote both cell adhesion and noncovalent DNA immobilization. Langmuir : the ACS journal of surfaces and colloids 19 18507410
2023 MAT1A Suppression by the CTBP1/HDAC1/HDAC2 Transcriptional Complex Induces Immune Escape and Reduces Ferroptosis in Hepatocellular Carcinoma. Laboratory investigation; a journal of technical methods and pathology 18 37230466
2018 Functional and Expression Analyses of the Pneumocystis MAT Genes Suggest Obligate Sexuality through Primary Homothallism within Host Lungs. mBio 18 29463658
2008 Molecular organization in SAMs used for neuronal cell growth. Langmuir : the ACS journal of surfaces and colloids 18 18338909
1991 AAR2, a gene for splicing pre-mRNA of the MATa1 cistron in cell type control of Saccharomyces cerevisiae. Molecular and cellular biology 18 1922071
2018 Going with the Flo: The Role of Flo11-Dependent and Independent Interactions in Yeast Mat Formation. Journal of fungi (Basel, Switzerland) 17 30544497
2016 Genetic Variants in CD44 and MAT1A Confer Susceptibility to Acute Skin Reaction in Breast Cancer Patients Undergoing Radiation Therapy. International journal of radiation oncology, biology, physics 17 27816361
2012 Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation. Drug metabolism and disposition: the biological fate of chemicals 17 22807109
2004 Lissencephaly with der(17)t(17;20)(p13.3;p12.2)mat. American journal of medical genetics. Part A 17 14708103
2022 Protein and polysaccharide-based asymmetric mat with tuned bilayer configuration for enhanced wound healing efficiency. Carbohydrate polymers 16 35725208
2019 Seasonal development of a coastal microbial mat. Scientific reports 16 31227767
2023 Antibacterial and antioxidant double-layered nanofibrous mat promotes wound healing in diabetic rats. Scientific reports 15 36823173
2020 Investigating the Smuts: Common Cues, Signaling Pathways, and the Role of MAT in Dimorphic Switching and Pathogenesis. Journal of fungi (Basel, Switzerland) 15 33339287
2014 Thirteen Patients with MAT1A Mutations Detected Through Newborn Screening: 13 Years' Experience. JIMD reports 15 24445979
2023 Electrospun nanofiber composite mat based on ulvan for wound dressing applications. International journal of biological macromolecules 14 37659492
2018 Engineering of Neuron Growth and Enhancing Cell-Chip Communication via Mixed SAMs. ACS applied materials & interfaces 14 29763286
2011 Vacuolar protein sorting genes regulate mat formation in Saccharomyces cerevisiae by Flo11p-dependent and -independent mechanisms. Eukaryotic cell 14 21908597
2010 MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations. Nutrition, metabolism, and cardiovascular diseases : NMCD 14 21185701
2022 Magnolol Hybrid Nanofibrous Mat with Antibacterial, Anti-Inflammatory, and Microvascularized Properties for Wound Treatment. Biomacromolecules 13 35067057
2019 Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. International journal of molecular sciences 13 31600961
2004 Repression of the yeast HO gene by the MATalpha2 and MATa1 homeodomain proteins. Nucleic acids research 13 15598821
2020 Mast Cell Activation Test (MAT). Methods in molecular biology (Clifton, N.J.) 12 32766980
2019 SAHH and SAMS form a methyl donor complex with CCoAOMT7 for methylation of phenolic compounds. Biochemical and biophysical research communications 12 31582217
2018 Low-Fouling Characteristics of Ultrathin Zwitterionic Cysteine SAMs. Langmuir : the ACS journal of surfaces and colloids 12 30056710
2015 MAT--gene structure and mating behavior of Hymenoscyphus fraxineus and Hymenoscyphus albidus. Fungal genetics and biology : FG & B 12 26724599
2023 Genomic and phenotypic characterization of a red-pigmented strain of Massilia frigida isolated from an Antarctic microbial mat. Frontiers in microbiology 11 37250028
2017 Formation of upd(7)mat by trisomic rescue: SNP array typing provides new insights in chromosomal nondisjunction. Molecular cytogenetics 11 28770003
2017 Methanogenic and Sulfate-Reducing Activities in a Hypersaline Microbial Mat and Associated Microbial Diversity. Microbial ecology 11 29116347
2016 Microbial Mat Compositional and Functional Sensitivity to Environmental Disturbance. Frontiers in microbiology 11 27799927
2003 Characterization of sams genes of Amoeba proteus and the endosymbiotic X-bacteria. The Journal of eukaryotic microbiology 11 12674481
2000 Cooperative ordering in homeodomain-DNA recognition: solution structure and dynamics of the MATa1 homeodomain. Biochemistry 11 10955992
2024 MAT1A activation of glycolysis to promote NSCLC progression depends on stabilizing CCND1. Cell death & disease 10 39438468
2023 MAT as a promising therapeutic strategy against triple-negative breast cancer via inhibiting PI3K/AKT pathway. Scientific reports 10 37524857
2022 Deep phenotyping: symptom annotation made simple with SAMS. Nucleic acids research 10 35524573
2013 Effects of hydrophobicity and mat thickness on release from hydrogel-electrospun fiber mat composites. Journal of biomaterials science. Polymer edition 10 23905840
2007 Electron transfer of plurimodified DNA SAMs. Langmuir : the ACS journal of surfaces and colloids 10 17590024
1988 Splicing and spliceosome formation of the yeast MATa1 transcript require a minimum distance from the 5' splice site to the internal branch acceptor site. Nucleic acids research 10 3054807

Missed literature

Know a paper Affinage missed for MAT1A? Flag it for the maintainers and the community.

No submissions yet.