Affinage

MAP7

Ensconsin · UniProt Q14244

Length
749 aa
Mass
84.1 kDa
Annotated
2026-06-10
33 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MAP7 (E-MAP-115/ensconsin) is a microtubule-associated protein that organizes the microtubule cytoskeleton and governs kinesin-1-based intracellular transport (PMID:8408219, PMID:30132755). Its N-terminal microtubule-binding domain engages the MT lattice as an extended alpha-helix wedged between the protofilament ridge and the lateral contact site, with contacts extending beyond a single tubulin dimer and onto tubulin C-terminal tails (PMID:35050657, PMID:38431715). A spatially distinct C-terminal projection domain directly binds kinesin-1 and recruits it to microtubules, producing biphasic control of motility: because the MTBD partially overlaps the kinesin-1 footprint, lattice saturation inhibits the motor, whereas at lower density the projection domain tethers kinesin-1 to the lattice, increases its binding rate and run length, and biases ensemble transport toward the plus-end without altering single-motor force (PMID:35050657, PMID:31085585, PMID:30132755). MAP7 functions as a productive-engagement factor rather than a de-repressor of kinesin-1 autoinhibition, complementing activators such as BicD, and its kinesin-1 binding is coupled to the cargo-activated open conformation of the motor (PMID:40384341). MAP7 also writes the tubulin code by promoting acetylation and inhibiting detyrosination, thereby tuning cargo transport and enabling adaptation to osmotic stress (PMID:38574732). At axon collateral branch points it binds the acetylated/stable lattice while avoiding the dynamic plus-end, creating a boundary that prevents depolymerization and branch retraction; its N-terminal microtubule-binding activity drives branch formation while the kinesin-1-binding domain supports branch and axon growth (PMID:28069923, PMID:30132755, PMID:31391261). MT binding is switched off by cell cycle-dependent threonine hyperphosphorylation in mitosis, releasing MAP7 from interphase microtubules (PMID:7490279). Genetic loss of MAP7 in mice causes male sterility through disorganized manchette and Sertoli-cell microtubules during spermatogenesis (PMID:10837026). Beyond its core cytoskeletal role, MAP7 participates in G1-phase DNA double-strand break repair through interactions with RAD50, BRCA1, and 53BP1 (PMID:36852271), and its protein stability is controlled by FBXW7-mediated K48-linked polyubiquitination (PMID:41382187).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 1993 High

    Established MAP7 as a microtubule-binding protein and mapped its activity to a basic N-terminal alpha-helical domain capable of stabilizing microtubules.

    Evidence In vitro MT-binding assays with domain mutants plus nocodazole-resistance readout in fibroblasts

    PMID:8408219

    Open questions at the time
    • Atomic binding mode unresolved
    • Whether stabilization reflects physiological function unclear
  2. 1995 High

    Showed MT binding is regulated by the cell cycle, defining mitotic threonine hyperphosphorylation as a switch that releases MAP7 from microtubules.

    Evidence 32P metabolic labeling, mobility shift, in vitro binding of mitotic vs interphase protein, cell-cycle immunolabeling in HeLa cells

    PMID:7490279

    Open questions at the time
    • Responsible kinase(s) not identified
    • Specific phosphorylated residues not mapped
  3. 1999 High

    Live imaging at physiological levels overturned the simple stabilizer model, showing MAP7 tracks lattice polymerization/depolymerization without altering dynamics in vivo.

    Evidence Dual-wavelength time-lapse imaging of GFP-EMTB chimeras across expression levels

    PMID:10564643

    Open questions at the time
    • Did not define the in vivo function that replaces stabilization
    • No partner identified
  4. 2000 High

    Genetic knockout assigned an essential in vivo role, linking MAP7 to microtubule organization required for spermatogenesis.

    Evidence Gene-trap null mouse with testis histology and microtubule immunolabeling

    PMID:10837026

    Open questions at the time
    • Molecular basis of manchette/Sertoli defect not dissected
    • No interacting partners identified at this stage
  5. 2017 High

    Identified MAP7 as a regulator of axon collateral branching, with the N-terminal half driving branch formation independently of kinesin-1.

    Evidence shRNA, overexpression, domain truncation, time-lapse imaging and mutant mouse in DRG neurons

    PMID:28069923

    Open questions at the time
    • Mechanism by which N-terminus nucleates branches unclear
    • Relationship to tubulin PTMs not addressed
  6. 2018 High

    Defined MAP7 as a kinesin-1 recruiter, separating a kinesin-1-binding domain (needed for axon/branch growth and organelle transport) from MT-binding sites (needed for branch formation).

    Evidence Domain deletions, Co-IP, live organelle transport imaging in sensory neurons

    PMID:30132755

    Open questions at the time
    • Did not resolve structural overlap between MAP7 and kinesin-1 sites
    • Quantitative effect on motor engagement not measured
  7. 2018 Medium

    Connected MAP7/MAP7D1 to Wnt5a signaling via Disheveled cortical targeting in a kinesin-1-dependent, evolutionarily conserved feedback loop.

    Evidence Co-IP, shRNA, live imaging, KIF5B depletion, Drosophila genetics

    PMID:29880710

    Open questions at the time
    • Single-lab interaction data
    • Direct vs indirect MAP7-Dvl binding not fully resolved
  8. 2019 High

    Quantified the transport mechanism, showing MAP7 biases plus-end-directed motility by increasing kinesin-1 binding rate and engaged motor number rather than per-motor force.

    Evidence In vitro phagosome reconstitution, single-molecule imaging, optical trapping

    PMID:31085585

    Open questions at the time
    • Did not address concentration-dependent inhibition
    • Structural basis of recruitment not shown
  9. 2019 High

    Explained branch stability mechanistically: MAP7 binds the acetylated/stable lattice and excludes the dynamic plus-end to form a boundary preventing depolymerization and retraction.

    Evidence Live single-MT imaging, laser severing, shRNA depletion, acetylated-tubulin colocalization

    PMID:31391261

    Open questions at the time
    • Whether acetylation recruits MAP7 or vice versa unresolved
    • In vivo branch-stability requirement not tested
  10. 2022 High

    Cryo-EM resolved the binding mode and reconciled opposing transport effects into a biphasic model: MTBD overlaps the kinesin-1 site (inhibition when saturated) while the projection domain tethers kinesin-1 (enhancement at low density).

    Evidence Cryo-EM structure of MAP7-MT complex plus single-molecule imaging

    PMID:35050657

    Open questions at the time
    • Conformational coupling to kinesin-1 activation state not addressed here
    • Role of tubulin tails not resolved
  11. 2023 Medium

    Extended MAP7 function beyond the cytoskeleton, implicating it in G1 DNA double-strand break repair through interactions with RAD50, BRCA1 and 53BP1.

    Evidence Quantitative proteomics, Co-IP, chromatin fractionation, repair-foci IF, gamma-irradiation in G1-arrested cells

    PMID:36852271

    Open questions at the time
    • Direct vs indirect interactions not separated
    • Mechanism linking MT-binding to chromatin repair unclear
    • Single-lab finding
  12. 2024 High

    Defined MAP7 as a tubulin-code modulator that promotes acetylation and inhibits detyrosination to tune transport and osmotic-stress adaptation.

    Evidence In vitro reconstitution with enzymatic assays and live-cell imaging under osmotic perturbation

    PMID:38574732

    Open questions at the time
    • Whether MAP7 directly recruits modifying enzymes not established
    • Acetylase/detyrosinase partners not identified
  13. 2024 High

    Provided atomic-level detail of lattice engagement, showing MAP7 MTBD contacts span beyond one tubulin dimer and include tubulin C-terminal tails.

    Evidence Solid- and solution-state NMR, EM, fluorescence anisotropy, ITC

    PMID:38431715

    Open questions at the time
    • Functional consequence of tail contacts for transport untested
    • Phosphoregulation of this interface not mapped
  14. 2025 High

    Clarified MAP7's role relative to autoinhibition: it enhances productive kinesin-1 engagement (run length, MT recruitment) without relieving autoinhibition, acting complementarily to BicD.

    Evidence Single-molecule motility assays with purified Drosophila proteins

    PMID:40384341

    Open questions at the time
    • Mammalian motor combinations not tested
    • In vivo coordination of BicD and MAP7 unknown
  15. 2025 Medium

    Linked MAP7 binding to the cargo-activated open conformation of kinesin-1, indicating allosteric coupling between motor activation and MAP7 engagement.

    Evidence Protein design, computational modelling, biophysics and EM of kinesin-1 holoenzyme (preprint)

    PMID:bio_10.1101_2025.04.08.647705

    Open questions at the time
    • Preprint, not peer-reviewed
    • Structural state of MAP7-bound open motor not directly resolved
  16. 2025 Medium

    Refined the spermatogenesis mechanism, showing MAP7 aligns apical Sertoli-cell microtubules and associates with non-muscle myosin II (MYH9/MYH10) to coordinate MT and F-actin.

    Evidence Conditional knockout, native-tissue imaging, proteomics, scRNA-seq (preprint)

    PMID:bio_10.1101_2025.09.16.676497

    Open questions at the time
    • Preprint, not peer-reviewed
    • Direct MAP7-myosin binding vs co-recruitment unresolved
  17. 2025 Medium

    Identified post-translational control of MAP7 abundance through FBXW7-mediated K48 polyubiquitination affecting tumor phenotypes and paclitaxel sensitivity.

    Evidence Co-IP, protein stability and ubiquitination assays, knockdown/overexpression in lung adenocarcinoma

    PMID:41382187

    Open questions at the time
    • Degron site on MAP7 not mapped
    • Single-lab finding

Open questions

Synthesis pass · forward-looking unresolved questions
  • How MAP7's cytoskeletal, transport, tubulin-code, signaling, and DNA-repair activities are integrated in a single cell, and which kinase enforces its mitotic phosphoregulation, remain unresolved.
  • Mitotic kinase for threonine hyperphosphorylation unidentified
  • Mechanistic basis of the non-cytoskeletal DNA-repair role unclear
  • Whether tubulin-PTM modulation is direct enzymatic recruitment unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0008092 cytoskeletal protein binding 3 GO:0060090 molecular adaptor activity 2
Localization
GO:0005856 cytoskeleton 3 GO:0005829 cytosol 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-1266738 Developmental Biology 2 R-HSA-73894 DNA Repair 1
Partners
53BP1BRCA1DVLFBXW7KIF5BMAP7D1MYH9RAD50

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1993 E-MAP-115 (MAP7) was identified as a novel microtubule-associated protein of 115 kDa with nucleotide-insensitive binding to microtubules. Its microtubule-binding site was localized to a basic alpha-helical region in the NH2-terminal domain using in vitro microtubule-binding assays and expression of mutant polypeptides. Overexpression of this domain in fibroblasts rendered microtubules stable to nocodazole, identifying it as a microtubule-stabilizing protein. In vitro microtubule-binding assays, mutant polypeptide expression, nocodazole resistance assay The Journal of cell biology High 8408219
1995 Binding of E-MAP-115 (MAP7) to microtubules is regulated by cell cycle-dependent phosphorylation. In mitotic HeLa cells, E-MAP-115 is hyperphosphorylated (~15-fold increase in 32P incorporation) specifically on threonine residues, and this hyperphosphorylated form cannot stably bind microtubules in vitro. The protein dissociates from microtubules in early prophase and progressively reassociates after late prophase, suggesting phosphorylation drives mitotic spindle assembly by releasing MAP7 from interphase microtubules. 32P metabolic labeling, SDS-PAGE mobility shift, in vitro microtubule-binding assay with mitotic vs. interphase protein, immunolabeling across cell cycle stages The Journal of cell biology High 7490279
1999 E-MAP-115 (ensconsin/MAP7) associates dynamically with microtubule lattices immediately upon polymerization and dissociates concomitant with depolymerization in vivo, as shown by dual-wavelength time-lapse fluorescence imaging with GFP-EMTB chimeras. Cells expressing four to ten times the physiological level of MAP7 showed microtubule dynamics indistinguishable from untransfected cells, establishing that MAP7 at physiological levels is NOT a microtubule stabilizer in vivo. Dual-wavelength time-lapse fluorescence live imaging, stable GFP-EMTB chimera cell lines, microinjection with labeled tubulin Journal of cell science High 10564643
2000 Genetic knockout of E-MAP-115 (MAP7) in mice causes male sterility due to deformation of spermatid nuclei and gradual loss of germ cells. Microtubule associations in the manchette of spermatids and in Sertoli cells were morphologically abnormal in null mice, establishing an essential in vivo role for MAP7 in microtubule organization required for spermatogenesis. Gene trap mutagenesis generating null allele, histological and morphological analysis of testes, immunolabeling of microtubule structures Genes & development High 10837026
2017 MAP7 is expressed at the onset of axon collateral branch formation in dorsal root ganglion (DRG) neurons, localizes to branch points colocalizing with stable microtubules, and its loss or overexpression alters axon branching. Domain analysis of a gain-of-function truncated MAP7 mutant mouse showed the amino-terminal half is responsible for branch formation independently of kinesin-1 interaction, establishing MAP7 as a regulator of axon collateral branch morphogenesis. shRNA knockdown, overexpression, domain truncation analysis, time-lapse imaging, spontaneous mutant mouse analysis, in vitro DRG culture branching assays The Journal of neuroscience High 28069923
2018 MAP7 recruits kinesin-1 to microtubules via direct interaction, using a kinesin-1-binding domain distinct from its two microtubule-binding sites. The kinesin-1-interacting domain is required for axon and branch growth but not branch formation, while both microtubule-binding sites are required for branch formation. MAP7 localizes to branch sites and dynamically recruits kinesin-1, altering organelle transport behaviors (pause/speed switching). Structure-function analysis with domain deletions, live-cell imaging of organelle transport, co-immunoprecipitation, sensory neuron culture knockdown/overexpression eLife High 30132755
2018 MAP7 and its paralog MAP7D1 bind Disheveled (Dvl), direct its cortical localization, and facilitate cortical targeting of microtubule plus-ends in response to Wnt5a signaling. Wnt5a signaling also promotes MAP7/7D1 movement toward MT plus-ends, and depletion of KIF5B (Kinesin-1) abolishes this MAP7/7D1 dynamics and Disheveled localization. This MAP7-Disheveled feedback loop and its role in Wnt5a signaling is evolutionarily conserved (shown also in Drosophila Ensconsin/Disheveled). Co-IP (MAP7/Dvl interaction), shRNA knockdown, live imaging, cortical localization assay, Drosophila genetic analysis EMBO reports Medium 29880710
2019 MAP7 shifts organelle (phagosome) transport toward the microtubule plus-end (~80% plus-end directed vs. ~50% without MAP7) by increasing the binding rate of kinesin-1 to microtubules without altering the force of individual motors. For ensembles of kinesin-1, MAP7 leads to more simultaneously engaged motors generating force, thereby biasing transport direction. In vitro phagosome motility reconstitution, single-molecule imaging of kinesin-1, optical trapping force measurements The Journal of biological chemistry High 31085585
2019 MAP7 prevents axon branch retraction by binding to the acetylated/stable region of individual microtubules while avoiding the dynamic plus-end, creating a boundary that prevents microtubule depolymerization and rescues polymerization. This boundary function maintains stable microtubules at branch junctions and can prevent branch retraction caused by laser-induced severing or nocodazole treatment. Live-cell imaging, MAP7 depletion (shRNA), laser-induced microtubule severing, single-microtubule dynamics analysis, colocalization with acetylated tubulin The Journal of neuroscience High 31391261
2022 Cryo-EM and single-molecule imaging revealed that the MAP7 microtubule-binding domain (MTBD) binds as an extended alpha-helix between the protofilament ridge and lateral contact site, partially overlapping with the kinesin-1 binding site, thereby inhibiting kinesin-1 motility when MTs are saturated with MAP7. However, the projection domain of MAP7 tethers kinesin-1 to the MT, preventing dissociation and facilitating binding to available neighboring sites, resulting in biphasic (concentration-dependent) regulation of kinesin-1 by MAP7. Cryo-electron microscopy, single-molecule imaging, structure determination of MAP7-MT complex Science High 35050657
2023 MAP7 and MAP7D1 interact with several DNA double-strand break repair proteins including RAD50, BRCA1, and 53BP1 (identified by quantitative proteomics). Downregulation of MAP7 and MAP7D1 in G1-arrested cells impairs DNA repair, reduces RAD50 recruitment to chromatin, and disrupts 53BP1 localization to damage sites, establishing a novel function for MAP7 in DNA double-strand break repair in the G1 phase. Quantitative proteomics, Co-IP, shRNA knockdown, chromatin fractionation, immunofluorescence of repair foci, gamma-irradiation assays iScience Medium 36852271
2024 MAP7 promotes tubulin acetylation and inhibits tubulin detyrosination, thereby modulating the tubulin code. These MAP7-driven tubulin PTM changes alter intracellular cargo transport, enabling cellular adaptation to osmotic stress. Human epithelial cells modulate MAP7 association with microtubules in response to changes in cytoplasmic density/osmolarity. Live-cell imaging, ex vivo enzymatic assays, in vitro reconstitution, quantification of tubulin PTMs under osmotic perturbation Developmental cell High 38574732
2024 Solid-state and solution-state NMR combined with electron microscopy, fluorescence anisotropy, and isothermal titration calorimetry revealed that MAP7 MTBD binds the MT lattice through interactions extending beyond a single tubulin dimer and including interactions with tubulin C-terminal tails, establishing the atomic-level binding mode of MAP7 to microtubules. Solid-state and solution-state NMR, electron microscopy, fluorescence anisotropy, isothermal titration calorimetry Nature communications High 38431715
2025 MAP7 enhances kinesin-1 engagement with microtubules (increasing run length and MT recruitment) without significantly relieving kinesin-1 auto-inhibition, while BicD relieves auto-inhibition. The combination of BicD and MAP7 produces the most robust kinesin-1 activation, demonstrating complementary mechanisms where MAP7 enables activated kinesin-1 motors to productively engage microtubules. Single-molecule motility assays with purified Drosophila proteins, quantitative analysis of motor processivity and run length Traffic (Copenhagen, Denmark) High 40384341
2025 Opening of the kinesin-1 heterotetrameric complex (transition from closed/autoinhibited to open state) facilitated by cargo SLiM binding to KLC TPR domains promotes binding to MAP7 on microtubules, establishing that MAP7 binding to kinesin-1 is allosterically coupled to the cargo-activated open conformation of the motor. Protein design, computational modelling, biophysical analysis, electron microscopy of kinesin-1 holoenzyme bioRxivpreprint Medium bio_10.1101_2025.04.08.647705
2025 MAP7 localizes preferentially to apical microtubules in Sertoli cells and MAP7-decorated microtubules become increasingly aligned along the tubule axis during apical domain maturation. In Map7-deficient testes, microtubule higher-order organization is disrupted with persistent luminal F-actin accumulation. Proteomic analysis identified non-muscle myosin II heavy chains MYH9 and MYH10 as MAP7-associated proteins, and MYH9 becomes enriched at luminal regions where microtubules and F-actin converge in a MAP7-dependent manner. Native-tissue imaging, conditional knockout, proteomics, single-cell RNA sequencing, immunofluorescence bioRxivpreprint Medium bio_10.1101_2025.09.16.676497
2020 MAP7 interacts with RC3H1 (identified by Co-IP) in cervical cancer cells, and the two proteins cooperatively enhance cyclin D1/cyclin B1 expression and facilitate cell-cycle progression via activation of canonical IKK/NF-κB signaling (increased P-IKK and P-p65). Co-immunoprecipitation, knockdown of MAP7 and RC3H1, western blot for NF-κB pathway components, xenograft model Biochemical and biophysical research communications Low 32446391
2025 FBXW7 promotes K48-linked polyubiquitination of MAP7, destabilizing MAP7 protein, as demonstrated by stability analysis and immunoprecipitation assays. This FBXW7-MAP7 axis regulates malignant cell phenotypes and paclitaxel sensitivity in lung adenocarcinoma. Co-immunoprecipitation, protein stability assay, ubiquitination assay, knockdown/overexpression European journal of medical research Medium 41382187

Source papers

Stage 0 corpus · 33 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 E-MAP-115 (ensconsin) associates dynamically with microtubules in vivo and is not a physiological modulator of microtubule dynamics. Journal of cell science 113 10564643
1993 Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells. The Journal of cell biology 96 8408219
2022 Structural and functional insight into regulation of kinesin-1 by microtubule-associated protein MAP7. Science (New York, N.Y.) 81 35050657
2000 E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis. Genes & development 62 10837026
2018 MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport. eLife 56 30132755
1995 Binding of E-MAP-115 to microtubules is regulated by cell cycle-dependent phosphorylation. The Journal of cell biology 54 7490279
2019 MAP7 regulates organelle transport by recruiting kinesin-1 to microtubules. The Journal of biological chemistry 50 31085585
2017 MAP7 Regulates Axon Collateral Branch Development in Dorsal Root Ganglion Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 43 28069923
2021 Plasma Exosomal CircNEK9 Accelerates the Progression of Gastric Cancer via miR-409-3p/MAP7 Axis. Digestive diseases and sciences 33 33449227
2024 Microtubule-associated protein MAP7 promotes tubulin posttranslational modifications and cargo transport to enable osmotic adaptation. Developmental cell 28 38574732
2020 MAP7 promotes migration and invasion and progression of human cervical cancer through modulating the autophagy. Cancer cell international 28 31956295
2014 C-terminal region of MAP7 domain containing protein 3 (MAP7D3) promotes microtubule polymerization by binding at the C-terminal tail of tubulin. PloS one 25 24927501
1999 GFP chimeras of E-MAP-115 (ensconsin) domains mimic behavior of the endogenous protein in vitro and in vivo. Cell structure and function 23 15216888
1998 The distribution of murine 115-kDa epithelial microtubule-associated protein (E-MAP-115) during embryogenesis and in adult organs suggests a role in epithelial polarization and differentiation. Differentiation; research in biological diversity 23 9745708
2019 MAP7 Prevents Axonal Branch Retraction by Creating a Stable Microtubule Boundary to Rescue Polymerization. The Journal of neuroscience : the official journal of the Society for Neuroscience 19 31391261
2018 Map7/7D1 and Dvl form a feedback loop that facilitates microtubule remodeling and Wnt5a signaling. EMBO reports 17 29880710
2019 MAP7 and MUCL1 Are Biomarkers of Vitamin D3-Induced Tolerogenic Dendritic Cells in Multiple Sclerosis Patients. Frontiers in immunology 14 31293564
1999 Upregulation and redistribution of E-MAP-115 (epithelial microtubule-associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts. The Journal of investigative dermatology 13 9989799
2020 MAP7 interacts with RC3H1 and cooperatively regulate cell-cycle progression of cervical cancer cells via activating the NF-κB signaling. Biochemical and biophysical research communications 11 32446391
2023 Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase. iScience 10 36852271
2001 Abundant expression of the microtubule-associated protein, ensconsin (E-MAP-115), alters the cellular response to Taxol. Cell motility and the cytoskeleton 8 11668581
2024 A structural and dynamic visualization of the interaction between MAP7 and microtubules. Nature communications 7 38431715
2025 BicD and MAP7 Collaborate to Activate Homodimeric Drosophila Kinesin-1 by Complementary Mechanisms. Traffic (Copenhagen, Denmark) 6 40384341
2024 MAP7 drives EMT and cisplatin resistance in ovarian cancer via wnt/β-catenin signaling. Heliyon 5 38726137
2022 MAP7 promotes proliferation and migration of breast cancer cells and reduces the sensitivity of breast cancer cells to paclitaxel. Journal of chemotherapy (Florence, Italy) 5 35657774
2022 MAP7 Promotes Breast Cancer Cell Migration and Invasion by Regulating the NF-B Pathway. Annals of clinical and laboratory science 5 36261182
2004 Cloning and characterization of an inversion breakpoint at 6q23.3 suggests a role for Map7 in sacral dysgenesis. Cytogenetic and genome research 5 15218243
2003 Microtubule-associated epithelial protein E-MAP-115 is localized in the spermatid manchette. International journal of andrology 4 12755995
2003 Expression and distribution of distinct variants of E-MAP-115 during proliferation and differentiation of human intestinal epithelial cells. Cell motility and the cytoskeleton 4 12845596
2023 Resonance assignments of the microtubule-binding domain of the microtubule-associated protein 7 (MAP7). Biomolecular NMR assignments 2 37099260
2025 BicD and MAP7 collaborate to activate homodimeric Drosophila kinesin-1 by complementary mechanisms. bioRxiv : the preprint server for biology 1 39868150
2025 FBXW7 regulates MAP7 through ubiquitination to affect the phenotypic characteristics and paclitaxel sensitivity of paclitaxel-resistant lung adenocarcinoma cells. European journal of medical research 0 41382187
2022 Clinical Significance of MAP-7 and FOXC1 in Egyptian Acute Myeloid Leukemia Patients. Asian Pacific journal of cancer prevention : APJCP 0 35633546

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