Affinage

MAGT1

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1 · UniProt Q9H0U3

Length
335 aa
Mass
38.0 kDa
Annotated
2026-06-10
46 papers in source corpus 18 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MAGT1 is a dual-function membrane protein that operates both as a magnesium transporter and as an accessory subunit of the protein N-glycosylation machinery, linking cellular Mg2+ status to immune and developmental signaling (PMID:19717468, PMID:31337704). It was first defined as a mammalian plasma-membrane Mg2+ transporter whose loss lowers total and free intracellular Mg2+ and whose expression is induced by low extracellular Mg2+, with an essential developmental role demonstrated by zebrafish knockdown (PMID:19717468). In parallel, MAGT1 is the human functional homolog of yeast OST3/OST6 and an obligate subunit of the STT3B oligosaccharyltransferase complex, mediating selective N-linked glycosylation of specific substrates including NKG2D, CD28, GLUT1, SHBG, SPARC, and platelet glycoproteins; its paralog TUSC3 is partly interchangeable and compensatorily upregulated upon MAGT1 loss (PMID:31337704, PMID:31036665, PMID:37207862, PMID:39632347). The glycosylation role can be uncoupled from Mg2+ supply: hypoglycosylation of NKG2D in MAGT1-deficient cells is not rescued by magnesium (PMID:35182234). Functionally, MAGT1 provides a TCR-stimulated Mg2+ flux required for PLCγ1 activation in T cells (PMID:21983175), shapes Ca2+/Mg2+ balance and PKC-dependent signaling in B cells and platelets (PMID:29581357, PMID:37381987), and is functionally linked to the TRPC6 channel in platelet cation balance and thrombosis, where TRPC6 haploinsufficiency normalizes GPVI signaling in Magt1-null mice (PMID:37381987). Loss of MAGT1 perturbs ERK/MAPK-dependent differentiation and cell-cycle progression in several cell types (PMID:30704530, PMID:34499581). Expression is regulated post-transcriptionally by miR-199a-5p (PMID:29051561, PMID:31038761, PMID:33210605) and channel activity is upregulated by PKC phosphorylation at conserved serine residues (PMID:23727583).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2008 Medium

    Established that MagT1 is a regulatable Mg2+ influx transporter at the protein level, answering whether it functions in cellular magnesium handling and responds to ambient Mg2+.

    Evidence RT-PCR, Western blot, immunocytochemistry and mag-fura 2 ion measurement in rumen epithelial cells

    PMID:18705540

    Open questions at the time
    • Channel/transporter mechanism not resolved structurally
    • Single tissue context
  2. 2009 High

    Defined MagT1 (and TUSC3) as bona fide mammalian plasma-membrane Mg2+ transporters with an essential in vivo developmental requirement, anchoring its transport function across species.

    Evidence Yeast complementation screen, siRNA knockdown with intracellular Mg2+ measurement, zebrafish morpholino knockdown with Mg2+/mRNA rescue

    PMID:19717468

    Open questions at the time
    • Did not distinguish direct channel activity from indirect effects
    • Substrate selectivity and gating mechanism unaddressed
  3. 2011 Medium

    Connected MAGT1-mediated Mg2+ flux to a defined signaling output by showing TCR-stimulated Mg2+ entry is required for PLCγ1 activation, establishing Mg2+ as a second messenger in T cells.

    Evidence Mg2+ flux and PLCγ1 phosphorylation assays in MAGT1-deficient XMEN patient T cells

    PMID:21983175

    Open questions at the time
    • Mechanistic link between Mg2+ and PLCγ1 not defined
    • Single lab
  4. 2011 Medium

    Showed MagT1 can substitute for a distinct Mg2+ uptake channel (TRPM7), supporting a genuine transport function with overlapping physiological roles.

    Evidence Overexpression in TRPM7-knockout DT40 B cells with Mg2+ uptake and growth rescue

    PMID:21627970

    Open questions at the time
    • Functional substitution does not prove identical transport mechanism
    • Heterologous overexpression system
  5. 2013 Medium

    Provided direct electrophysiological evidence that MagT1 is a Mg2+-selective non-voltage-dependent channel and identified PKC phosphosites controlling its activity.

    Evidence Patch-clamp of Drosophila MagT1 in SH-SY5Y cells with PMA activation and Ser-to-Ala mutagenesis (S100A, S108A)

    PMID:23727583

    Open questions at the time
    • Demonstrated in Drosophila ortholog, not mammalian protein
    • PKC isoform and in vivo relevance unresolved
  6. 2017 Medium

    Identified a post-transcriptional control mechanism, showing miR-199a-5p directly suppresses MAGT1 protein and links its depletion to T-cell dysfunction in disease.

    Evidence Luciferase reporter assay, miRNA overexpression/knockdown, qRT-PCR and Western blot in CD8+ T cells

    PMID:29051561 PMID:31038761 PMID:33210605

    Open questions at the time
    • Whether miRNA regulation operates in healthy tissue physiology unclear
    • Downstream consequences mostly correlative
  7. 2018 High

    Used a clean knockout mouse to show MAGT1 shapes B-cell Ca2+/Mg2+ homeostasis and PKC-dependent BCR signaling and alters B-cell subset composition in vivo.

    Evidence Magt1-knockout mouse, ion measurement, BCR stimulation, phosphoprotein Western blots, flow cytometry

    PMID:29581357

    Open questions at the time
    • Whether B-cell phenotype reflects transport or glycosylation function not separated
    • Causal chain from ion flux to subset frequencies incomplete
  8. 2018 Medium

    Demonstrated an essential developmental role with specific pathway epistasis, linking MagT1 to Wingless/Wnt and Decapentaplegic/BMP signaling during morphogenesis.

    Evidence Drosophila clonal analysis, RNAi in wing discs, signaling readouts, S2 cell Mg2+ transport assay

    PMID:29959918

    Open questions at the time
    • Molecular mechanism linking Mg2+/MagT1 to Wnt and BMP unresolved
    • Drosophila ortholog only
  9. 2019 High

    Resolved the second core function: MAGT1 is the OST3/OST6 homolog and an STT3B oligosaccharyltransferase subunit driving selective N-glycosylation, reframing XMEN as a glycosylation disorder.

    Evidence Glycoproteomics, CRISPR knockouts, NK killing assays, RNA-seq, patient transferrin/GLUT1/SHBG glycosylation analyses, TUSC3 comparison

    PMID:31036665 PMID:31337704

    Open questions at the time
    • How the transporter and glycosylation activities are coordinated mechanistically
    • Determinants of substrate selectivity within STT3B unclear
  10. 2019 Medium

    Linked MagT1-dependent Mg2+ transport to ERK/MAPK-driven osteogenic/odontogenic differentiation, extending its role to stem cell fate.

    Evidence shRNA knockdown in BMMSCs, Mg2+ measurement, ERK phospho-Western, differentiation markers, RNA-seq

    PMID:30704530

    Open questions at the time
    • Whether effect is transport- or glycosylation-mediated not distinguished
    • Single lab
  11. 2021 Medium

    Implicated MAGT1 in cell-cycle progression and survival, showing its loss arrests S phase, induces apoptosis and dampens MAPK signaling in HPV-driven cells.

    Evidence siRNA knockdown in HeLa, cell cycle and apoptosis flow cytometry, Western blots for MAPK and cyclins, RNA-seq

    PMID:34499581

    Open questions at the time
    • Direct molecular driver of cell-cycle arrest not identified
    • Transport vs glycosylation contribution unresolved
  12. 2022 High

    Uncoupled the two functions by showing the NKG2D hypoglycosylation defect is site-specific and is NOT rescued by magnesium, establishing the glycosylation defect as Mg2+-independent.

    Evidence CRISPR-engineered human cells, site-specific glycosylation mapping, NKG2D flow cytometry, Mg2+ supplementation in cells and patient

    PMID:35182234

    Open questions at the time
    • Why some substrate glycosylation responds to Mg2+ while NKG2D does not
    • Therapeutic implications beyond NKG2D
  13. 2023 Medium

    Extended the glycosylation function to platelet biology, showing MAGT1 deficiency hypoglycosylates GPIbα, GPVI and integrin αIIb with functional aggregation defects correctable by transplantation.

    Evidence Platelet aggregation, calcium flux, integrin activation, N-glycan mass spectrometry, pre/post-HSCT comparison in patients

    PMID:37207862

    Open questions at the time
    • Single patient/lab context
    • Relative contribution of each hypoglycosylated glycoprotein unclear
  14. 2023 High

    Established a genetic and functional link between MAGT1 and the TRPC6 channel in platelet cation balance, showing MAGT1 loss causes Ca2+-overload-driven hyperactive GPVI signaling and prothrombotic phenotypes correctable by TRPC6 reduction.

    Evidence Magt1-knockout mice, in vivo thrombosis and stroke models, platelet phospho-Western, Ca2+ flux, TRPC6/Magt1 double mutants, pharmacology, XMEN patient platelets

    PMID:37381987

    Open questions at the time
    • Physical versus functional nature of MAGT1-TRPC6 interaction not defined
    • How Mg2+ deficit drives Ca2+ overload mechanistically unresolved
  15. 2024 Medium

    Connected MagT1-driven Mg2+ uptake to SPARC N-glycosylation, secretion and mineral deposition, integrating its transport and glycosylation roles in osteogenesis.

    Evidence RNAi knockdown, glycosylation inhibitors, immunostaining, DDC-SEM and rat skull defect model

    PMID:39632347

    Open questions at the time
    • Whether SPARC glycosylation depends on Mg2+ flux or STT3B activity not separated
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how MAGT1's Mg2+ transport activity and its STT3B oligosaccharyltransferase subunit role are mechanistically coordinated, and what structural features govern its substrate selectivity and Mg2+ dependence.
  • No structural model integrating transport and glycosylation functions
  • Substrate selectivity rules of MAGT1-STT3B undefined
  • Mechanism by which Mg2+ levels influence only a subset of glycosylation substrates unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 4 GO:0140096 catalytic activity, acting on a protein 4 GO:0016740 transferase activity 2 GO:0060089 molecular transducer activity 2
Localization
GO:0005783 endoplasmic reticulum 2 GO:0005886 plasma membrane 2
Pathway
R-HSA-392499 Metabolism of proteins 4 R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 3 R-HSA-109582 Hemostasis 2 R-HSA-1266738 Developmental Biology 2
Partners
TRPC6TUSC3
Complex memberships
STT3B oligosaccharyltransferase (OST-B) complex

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 MagT1 and TUSC3 function as mammalian plasma membrane Mg2+ transporters: knockdown of either protein significantly lowers total and free intracellular Mg2+ concentrations in mammalian cell lines; MagT1 was identified via yeast complementation screen and its expression is upregulated in low extracellular Mg2+; morpholino knockdown in zebrafish causes early developmental arrest rescued by excess Mg2+ or mammalian mRNA supplementation. Yeast complementation screen, siRNA knockdown with intracellular Mg2+ measurement (mag-fura 2), zebrafish morpholino knockdown with rescue experiments Proceedings of the National Academy of Sciences of the United States of America High 19717468
2011 MAGT1 mediates a TCR-stimulated Mg2+ flux required for T cell activation; loss of MAGT1 abolishes this flux and attenuates PLCγ1 activation, identifying Mg2+ as a second messenger in the TCR signaling pathway. Intracellular Mg2+ flux measurement in T cells from XMEN patients (MAGT1-deficient), PLCγ1 phosphorylation assay, loss-of-function human patient cells Magnesium research Medium 21983175
2011 MagT1 overexpression in TRPM7-knockout DT40 B cells augments Mg2+ uptake capacity and rescues growth impairment, demonstrating that MagT1 can partially substitute for TRPM7 as a Mg2+ uptake mechanism; MagT1 expression is upregulated in TRPM7-/- cells. Gene expression analysis, overexpression in TRPM7-/- cells with Mg2+ uptake measurement and cell growth assay FEBS letters Medium 21627970
2013 Drosophila MagT1 (ortholog of mammalian MAGT1) is a magnesium-selective, non-voltage-dependent channel; its whole-cell currents are upregulated by PKC activation via PMA treatment; PKC-dependent modulation requires Ser100 and Ser108 phosphorylation sites (S100A and S108A mutants abolish PKC-dependent upregulation, while S35A does not). Patch-clamp electrophysiology in SH-SY5Y cells expressing wild-type or mutant dMagT1, PKC activator (PMA) treatment with inactive control (4α-PMA), site-directed mutagenesis Biochemical and biophysical research communications Medium 23727583
2018 Loss of MAGT1 in mouse B cells impairs Mg2+ homeostasis and increases Ca2+ influx after BCR stimulation, leading to increased phosphorylation of BCR-related proteins with differential effects on PKC activation; Magt1-knockout mice show increased CD19+ and marginal zone B cell frequencies and decreased plasma cell frequencies in spleen. Magt1-knockout mouse model, intracellular ion measurement, BCR stimulation assays, flow cytometry, Western blot for phosphoproteins Journal of immunology High 29581357
2018 MagT1 is essential for early Drosophila embryonic development; clonal analysis and RNAi knockdown in wing discs show that loss of MagT1 enhances/ectopically activates Wingless (Wnt) signaling and disrupts Decapentaplegic (BMP/TGF-β) signaling; magnesium transport is proportional to MagT1 expression levels in Drosophila S2 cells. Drosophila MagT1 mutant generation, clonal analysis, RNAi knockdown, signaling pathway readouts in wing primordia, Mg2+ transport assay in S2 cells Biochemical and biophysical research communications Medium 29959918
2019 MAGT1 is the human functional homolog of yeast OST3/OST6 and acts as a subunit of the STT3B oligosaccharyltransferase (OST) complex; MAGT1 deficiency causes selective N-linked glycosylation defects in immune and non-immune glycoproteins including NKG2D and CD28; MAGT1-dependent glycosylation is sensitive to Mg2+ levels; MAGT1 function is partly interchangeable with paralog TUSC3 but they have different tissue distributions. MS-based glycoproteomics, CRISPR/Cas9 knockout cell lines, NK cell killing assays, RNA-seq, comparison with TUSC3 The Journal of biological chemistry High 31337704
2019 MAGT1 acts as a subunit of the STT3B OST complex mediating N-linked glycosylation; patient cells with MAGT1 mutations show defective post-translational glycosylation of GLUT1 and SHBG (STT3B complex substrates); MAGT1 deficiency is associated with compensatory upregulation of TUSC3. Serum transferrin glycosylation analysis in patients, glycosylation substrate analysis (GLUT1, SHBG), patient fibroblast functional studies, protein expression analysis Proceedings of the National Academy of Sciences of the United States of America High 31036665
2022 Reduced steady-state NKG2D (KLRK1) levels in MAGT1-deficient patients are caused by hypoglycosylation of NKG2D protein at a specific site; magnesium supplementation does not rescue NKG2D expression or the hypoglycosylation defect in CRISPR-engineered human cell lines or in an XMEN patient. CRISPR-engineered human cell lines, site-specific glycosylation mapping, flow cytometry for NKG2D surface expression, Mg2+ supplementation experiments in cells and patient Human genetics High 35182234
2019 MagT1 knockdown in bone marrow mesenchymal stem cells (BMMSCs) reduces intracellular Mg2+, suppresses odontogenic differentiation markers (ALP, DMP-1, DSP), inhibits mineralization, and inactivates the ERK/MAPK signaling pathway; ERK/MAPK pathway activation is required downstream of MagT1-mediated Mg2+ transport for odontogenic differentiation. shRNA lentiviral knockdown, intracellular Mg2+ measurement, Western blot for ERK phosphorylation and differentiation markers, flow cytometry, RNA-seq Stem cell research & therapy Medium 30704530
2021 MAGT1 knockdown in HeLa cells causes S-phase arrest and apoptosis, reduces ERK1/2 and p38 phosphorylation, increases p21 expression, and alters expression of cell cycle regulators (cyclin-A1, cyclin-B1, MYC, cyclin-D1, cyclin-E1, CDK2); MAGT1 is required for HPV E6/E7-dependent cell cycle progression. siRNA knockdown, cell cycle analysis by flow cytometry, Western blot for MAPK phosphorylation and cell cycle proteins, RNA-seq Cell cycle Medium 34499581
2023 MAGT1 deficiency in platelets causes defective N-glycosylation of glycoprotein Ibα, glycoprotein VI, and integrin αIIb, leading to impaired platelet aggregation, integrin αIIbβ3 activation, calcium mobilization, PKC activity, and absent PAR1-AP responses; these defects were corrected after hematopoietic stem cell transplantation. Platelet function testing (aggregation, calcium flux, integrin activation), N-glycan analysis by mass spectrometry, Western blot for glycoprotein molecular weights, pre/post-HSCT comparison Journal of thrombosis and haemostasis Medium 37207862
2023 MAGT1-deficient mice show accelerated arterial thrombosis, shortened bleeding time, and increased GPVI-dependent platelet aggregation due to increased Ca2+ influx and hyperphosphorylation of Syk, LAT, and PLCγ2; the inhibitory PKC loop is impaired; MgCl2 supplementation or TRPC6 channel blockade normalizes aggregation; haploinsufficiency of TRPC6 in Magt1-/- mice normalizes GPVI signaling and thrombus formation in vivo, establishing functional linkage between MAGT1 and TRPC6. Magt1-knockout mouse model, in vivo arterial thrombosis models, transient MCAO stroke model, platelet signaling (phospho-Western blot), Ca2+ flux measurement, pharmacological inhibition, TRPC6/Magt1 double-mutant mice, human XMEN patient platelet validation Arteriosclerosis, thrombosis, and vascular biology High 37381987
2008 MagT1 protein is expressed in rumen epithelial cells and functions as a Mg2+ influx transporter; its protein abundance is regulated by extracellular Mg2+ concentration (decreased by low Mg2+, increased by high Mg2+); functional Mg2+ transport capacity is correspondingly altered. RT-PCR, Western blot, flow cytometry, immunocytochemistry, intracellular Mg2+ measurement with mag-fura 2 Magnesium research Medium 18705540
2024 MagT1 mediates Mg2+ uptake required for N-linked glycosylation of SPARC (secreted protein acidic and rich in cysteine); SPARC glycosylation affects its extracellular secretion and mineral deposition; established using RNAi knockdown and glycosylation inhibitors in the context of magnesium-impregnated membrane-driven osteogenesis. RNAi knockdown, glycosylation inhibitors, immunostaining, DDC-SEM for mineral deposition, in vivo rat skull defect model Advanced healthcare materials Medium 39632347
2017 miR-199a-5p directly targets MAGT1 mRNA and suppresses its expression post-transcriptionally, validated by luciferase reporter assay; this mechanism contributes to reduced MAGT1 protein (without mRNA change) and functional depletion of CD8+ T cells in chronic HBV infection. Luciferase reporter assay, lentiviral overexpression/knockdown of miR-199a-5p, qRT-PCR for mRNA, Western blot for protein, immune function assays Scientific reports / Magnesium research Medium 29051561 31038761 33210605

Source papers

Stage 0 corpus · 46 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proceedings of the National Academy of Sciences of the United States of America 166 19717468
2019 Magnesium transporter 1 (MAGT1) deficiency causes selective defects in N-linked glycosylation and expression of immune-response genes. The Journal of biological chemistry 83 31337704
2019 Mutations in MAGT1 lead to a glycosylation disorder with a variable phenotype. Proceedings of the National Academy of Sciences of the United States of America 80 31036665
2011 Loss of MAGT1 abrogates the Mg2+ flux required for T cell signaling and leads to a novel human primary immunodeficiency. Magnesium research 54 21983175
2014 Identification of a novel mutation in MAGT1 and progressive multifocal leucoencephalopathy in a 58-year-old man with XMEN disease. Journal of clinical immunology 52 25504528
2011 The Mg2+ transporter MagT1 partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7. FEBS letters 50 21627970
2021 CRISPR-targeted MAGT1 insertion restores XMEN patient hematopoietic stem cells and lymphocytes. Blood 30 34086870
2008 Expression and functional activity of the Na/Mg exchanger, TRPM7 and MagT1 are changed to regulate Mg homeostasis and transport in rumen epithelial cells. Magnesium research 26 18705540
2020 Sevoflurane Regulates Glioma Progression by Circ_0002755/miR-628-5p/MAGT1 Axis. Cancer management and research 25 32669871
2018 TRPM7 and MagT1 in the osteogenic differentiation of human mesenchymal stem cells in vitro. Scientific reports 22 30385806
2017 The different expression of TRPM7 and MagT1 impacts on the proliferation of colon carcinoma cells sensitive or resistant to doxorubicin. Scientific reports 19 28094304
2022 Transcription factor KLF16 activates MAGT1 to regulate the tumorigenesis and progression of breast cancer. International journal of molecular medicine 18 35796007
2019 MagT1 regulated the odontogenic differentiation of BMMSCs induced byTGC-CM via ERK signaling pathway. Stem cell research & therapy 17 30704530
2018 Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B Cells Dysregulates B Cell Development and Signaling in Mice. Journal of immunology (Baltimore, Md. : 1950) 17 29581357
2021 MAGT1 is required for HeLa cell proliferation through regulating p21 expression, S-phase progress, and ERK/p38 MAPK MYC axis. Cell cycle (Georgetown, Tex.) 16 34499581
2015 Role of Magnesium Transporter Subtype 1 (MagT1) in the Osteogenic Differentiation of Rat Bone Marrow Stem Cells. Biological trace element research 16 26358767
2019 microRNA-199a-5p suppresses glioma progression by inhibiting MAGT1. Journal of cellular biochemistry 15 31038761
2019 The simultaneous downregulation of TRPM7 and MagT1 in human mesenchymal stem cells in vitro: Effects on growth and osteogenic differentiation. Biochemical and biophysical research communications 13 30952425
2020 MAGT1 messenger RNA-corrected autologous T and natural killer cells for potential cell therapy in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia disease. Cytotherapy 12 33051095
2017 MAGT1-mediated disturbance of Mg2+ homeostasis lead to exhausted of HBV-infected NK and CD8+ T cells. Scientific reports 12 29051561
2023 MAGT1 deficiency in XMEN disease is associated with severe platelet dysfunction and impaired platelet glycoprotein N-glycosylation. Journal of thrombosis and haemostasis : JTH 11 37207862
2022 Lack of NKG2D in MAGT1-deficient patients is caused by hypoglycosylation. Human genetics 11 35182234
2022 Identification of a novel MAGT1 mutation supports a diagnosis of XMEN disease. Genes and immunity 11 35264785
2023 MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice. Arteriosclerosis, thrombosis, and vascular biology 10 37381987
2014 Variant ATRX syndrome with dysfunction of ATRX and MAGT1 genes. Human mutation 9 24130152
2015 The role of MAGT1 in genetic syndromes. Magnesium research 8 26422833
2021 Case Report: EBV-Positive Extra-Nodal Marginal Zone Lymphoma Associated With XMEN Disease Caused by a Novel Hemizygous Mutation in MAGT1. Frontiers in oncology 7 33869058
2021 TCF12 activates MAGT1 expression to regulate the malignant progression of pancreatic carcinoma cells. Oncology letters 7 35069871
2013 Drosophila MagT1 is upregulated by PKC activation. Biochemical and biophysical research communications 7 23727583
2023 Polarization of THP-1-Derived Macrophage by Magnesium and MAGT1 Inhibition in Wound Healing. Archives of plastic surgery 6 37564721
2024 HLH and Recurrent EBV Lymphoma as the presenting manifestation of MAGT1 Deficiency: A Systematic Review of the Expanding Disease Spectrum. Journal of clinical immunology 5 38896122
2023 CD5 B-Cell Predominant Primary Immunodeficiency: Part of the Spectrum of MAGT1 Deficiency. Therapeutic advances in allergy and rhinology 5 37706151
2022 Long non-coding RNA FLVCR1-AS1 functions as a ceRNA to aggravate cervical cancer cell growth by the miR-381-3p/MAGT1 axis. Archives of gynecology and obstetrics 5 35430713
2021 Successful Anti-SARS-CoV-2 Spike Protein Antibody Response to Vaccination in MAGT1 Deficiency. Allergy & rhinology (Providence, R.I.) 5 34868726
2024 Magnesium-Impregnated Membrane Promotes Bone Regeneration in Rat Skull Defect by N-Linked Glycosylation of SPARC via MagT1. Advanced healthcare materials 4 39632347
2023 The Interplay between TRPM7 and MagT1 in Maintaining Endothelial Magnesium Homeostasis. Membranes 4 36984673
2022 Novel MAGT1 Mutation Found in the First Chinese XMEN in Hong Kong. Case reports in immunology 4 35198253
2022 Scales of Magt1 Gene: Novel Mutations, Different Presentations. Iranian journal of allergy, asthma, and immunology 4 35524383
2024 XMEN disease caused by the novel MAGT1 p.(Trp136*) mutation may present with neuropsychiatric symptoms. Journal of neuroimmunology 3 38878600
2018 MagT1 is essential for Drosophila development through the shaping of Wingless and Decapentaplegic signaling pathways. Biochemical and biophysical research communications 2 29959918
2025 Effects of two different variants in the MAGT1 gene on B cell subsets, platelet function, and cell glycome composition. Frontiers in immunology 1 40170846
2020 TRPM7 and MagT1 regulate the proliferation of osteoblast-like SaOS-2 cells through different mechanisms. Magnesium research 1 32633723
2020 miR-199a-5p targeted regulation of MAGT1 expression in the functional depletion of CD8+T cells in HBV infection. Magnesium research 1 33210605
2026 Case Report: Novel MAGT1 pathogenic variant with significant atopy, hypogammaglobulinemia and viral skin infections. Frontiers in immunology 0 41777878
2026 Modifier-Sensitive Phenotypic Divergence in XMEN Disease (MAGT1 Deficiency): Neurodegenerative and Immuno-Hematologic Trajectories. Journal of clinical medicine 0 41899319
2024 Loss-of-function variant in MAGT1 leading to XMEN disease in a Colombian patient with a common variable immunodeficiency. Biomedica : revista del Instituto Nacional de Salud 0 39836832

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