Affinage

LGALS8

Galectin-8 · UniProt O00214

Audit flag: ungrounded claim
Length
317 aa
Mass
35.8 kDa
Annotated
2026-06-10
64 papers in source corpus 16 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LGALS8/galectin-8 is a cytosolic β-galactoside-binding lectin that serves as a danger receptor surveying endomembrane integrity: upon lysosomal, endosomal, or pathogen-containing vacuole damage, luminal host glycans become exposed on the cytosolic face and are bound by galectin-8, which marks the damaged compartment for selective autophagy across bacterial (Salmonella, Listeria, Shigella), viral (picornavirus), and sterile injuries (PMID:22246322, PMID:28077878). Glycan-bound galectin-8 recruits the autophagy adaptor CALCOCO2/NDP52 through a binding interface distinct from its LC3C/maturation interface, providing transient cargo targeting that precedes ubiquitin-dependent recruitment (PMID:22246322, PMID:25998689); NDP52 in turn assembles the ULK and TBK1 kinase complexes as a trimer with RB1CC1/FIP200 and TBKBP1-AZI2/NAP1 to nucleate phagophore formation directly at the cargo (PMID:31258038). Beyond a passive 'eat-me' tag, galectin-8 acts as an active signaling node, inhibiting MTOR and activating AMPK upon lysosomal damage (PMID:30081722), with MTOR inactivation occurring at the damaged lysosome through the Ragulator-RRAGA/RRAGB complex together with NUFIP2 under the control of GABARAP-dependent membrane Atg8ylation (PMID:36394332). Extracellularly, galectin-8 promotes pathological lymphangiogenesis through VEGF-C/podoplanin/integrin (α1β1, α5β1) crosstalk independent of VEGFR-3 (PMID:27066737) and activates dendritic cells to mature and secrete proinflammatory cytokines, enhancing antigen-specific CD4 T-cell responses (PMID:28811319). An isoform-specific role exists in human osteoclasts, where the short isoform predominantly drives bone resorption and mTORC1 signaling via interactions with lysosomal/secretory vesicle proteins CLCN3, CLCN7, LAMP1, and LAMP2 (PMID:38395460).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1996 Medium

    Established the existence and basic biochemistry of the gene product, defining it as a secreted galectin-family-related protein before any cellular function was known.

    Evidence Surface-epitope masking immunological subtraction and cDNA expression cloning from human LNCaP prostate cancer cells

    PMID:8692978

    Open questions at the time
    • No functional or mechanistic role assigned
    • Glycan-binding specificity not characterized
    • Relationship to autophagy/immunity unknown
  2. 2012 High

    Resolved how the cell detects damaged intracellular vesicles, showing galectin-8 is a cytosolic danger receptor that senses exposed luminal glycans and links membrane damage to selective autophagy.

    Evidence Loss-of-function, Co-IP, fluorescence microscopy and infection with multiple pathogens plus sterile lysosome-damaging agents in human cells

    PMID:22246322

    Open questions at the time
    • Did not define the downstream kinase machinery recruited
    • Did not separate cargo-targeting from autophagosome maturation functions
  3. 2015 Medium

    Defined the molecular logic of adaptor recruitment by mapping that NDP52 engages galectin-8 through a domain separate from its LC3C-binding interface, separating cargo targeting from maturation.

    Evidence Domain-mapping deletion mutants, Co-IP and imaging in Salmonella-infected cells

    PMID:25998689

    Open questions at the time
    • Single-lab structural detail without crystallographic interface
    • How glycan-bound galectin-8 hands off to ubiquitin-dependent recruitment not resolved
  4. 2016 High

    Extended galectin-8 function beyond intracellular surveillance, establishing an extracellular role in pathological lymphangiogenesis acting through integrins rather than VEGFR-3.

    Evidence Lgals8−/− and Pdpn−/− mouse models, corneal allograft and HSV keratitis models, VEGFR-3/integrin knockdown and LEC sprouting assays

    PMID:27066737

    Open questions at the time
    • Direct receptor for secreted galectin-8 on LECs not defined
    • Connection between intracellular and extracellular roles unaddressed
  5. 2017 High

    Generalized galectin-8 sensing to non-bacterial breach by showing it detects picornavirus-permeated endosomes and routes them for autophagic clearance, in competition with viral escape factor PLA2G16.

    Evidence Genome-wide haploid suppressor screen with epistasis and infection assays

    PMID:28077878

    Open questions at the time
    • Whether the same adaptor cascade operates for viral cargo not shown
    • Glycan source on virus-permeated endosomes not detailed
  6. 2017 Medium

    Demonstrated an immunostimulatory role linking galectin-8 to adaptive immunity through dendritic cell maturation.

    Evidence BMDCs from Lgals8 knockout mice, flow cytometry, cytokine ELISA, T-cell co-culture and in vivo FMDV challenge

    PMID:28811319

    Open questions at the time
    • Receptor mediating DC activation not identified
    • Single-lab study
    • Intracellular vs secreted galectin-8 contribution not separated
  7. 2018 High

    Reframed galectin-8 from a passive autophagy tag into an active signal transducer that reprograms metabolic master regulators MTOR and AMPK upon lysosomal damage.

    Evidence Lysosomal damage assays, MTOR/AMPK activity measurements, galectin KO/KD and APEX2 proximity proteomics

    PMID:30081722

    Open questions at the time
    • Molecular link between glycan binding and kinase modulation not yet defined
    • Did not place MTOR control on the Ragulator axis
  8. 2019 High

    Connected galectin-8 danger sensing to de novo autophagosome nucleation by defining the NDP52-recruited ULK/TBK1 trimeric complex at cargo sites.

    Evidence Reciprocal Co-IP, dominant-negative/mutant constructs, microscopy and autophagy induction in Salmonella-infected cells

    PMID:31258038

    Open questions at the time
    • Kinetics of complex assembly relative to galectin-8 binding not resolved
    • Stoichiometry in vivo not determined
  9. 2020 Medium

    Identified an upstream regulatory layer showing pathogens suppress galectin-8 to evade cell-autonomous immunity.

    Evidence miRNA profiling, ChIP-seq, proteomics, and miRNA overexpression/inhibition with bacterial replication readout in human macrophages during Legionella infection

    PMID:32209695

    Open questions at the time
    • Direct miRNA-target validation on LGALS8 3'UTR not detailed
    • Single-lab study
  10. 2022 High

    Placed galectin-8-driven MTOR inactivation precisely at the damaged lysosome on the Ragulator-RRAGA/B axis, controlled by Atg8ylation.

    Evidence LysoIP proteomics, MTOR activity assays, Atg8ylation-deficient mutants and microscopy

    PMID:36394332

    Open questions at the time
    • Direct biochemical contact of galectin-8 with Ragulator components not shown
    • How NUFIP2 cooperation is regulated unclear
  11. 2024 High

    Revealed isoform-specialized function, with the short galectin-8 isoform driving osteoclast bone resorption and mTORC1 signaling via defined lysosomal/secretory vesicle protein interactions.

    Evidence Isoform-specific siRNA knockdown, LC-MS/MS proteomics in HEK293T, Co-IP validation in human osteoclasts and bone resorption assays

    PMID:38395460

    Open questions at the time
    • Whether CLCN3/CLCN7/LAMP1/LAMP2 binding is glycan-dependent not shown
    • Mechanistic link to mTORC1 in osteoclasts not fully resolved
  12. 2024 Medium

    Identified post-transcriptional control of LGALS8 by m6A and connected its expression to vascular development.

    Evidence RNA-seq, MeRIP-seq, IGF2BP2 knockdown in endothelial cells, zebrafish vascular assays and LGALS8 rescue

    PMID:39722688

    Open questions at the time
    • Direct m6A sites on LGALS8 not mapped to function
    • Single-lab study
    • Mechanism of angiogenesis defect downstream of LGALS8 unclear
  13. 2024 Medium

    Delimited pathway specificity by showing CALCOCO2-dependent anti-HBV lysosomal degradation does not require galectin-8, distinguishing it from galectin-8-dependent antibacterial xenophagy.

    Evidence LGALS8-independent CALCOCO2 mutant analysis, ATG5 KO and RAB9-dependent pathway assays in HBV-infected cells

    PMID:38752371

    Open questions at the time
    • Why HBV clearance bypasses galectin-8 not mechanistically explained
    • Generality across other viruses untested in this study
  14. 2025 Medium

    Defined an organ-protective role for endogenous galectin-8 in limiting maladaptive fibrotic repair after kidney injury.

    Evidence Lgals8−/− mouse folic acid-induced AKI model with immune profiling, fibrosis histology and RT-qPCR

    PMID:40375122

    Open questions at the time
    • Cell-intrinsic vs systemic source of galectin-8 not resolved
    • Mechanistic link between galectin-8 and ECM/Th17 regulation not defined
    • Single-lab study

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how glycan binding by galectin-8 is mechanistically transduced into MTOR/AMPK/TFEB signaling and adaptor recruitment, and how its intracellular surveillance and extracellular lectin functions are coordinated.
  • No structural model of galectin-8 engaging signaling complexes
  • Direct biochemical bridge from glycan sensing to kinase regulation unknown
  • Coordination of secreted vs cytosolic pools uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0140299 molecular sensor activity 3 GO:0060089 molecular transducer activity 2
Localization
GO:0005764 lysosome 3 GO:0005576 extracellular region 2 GO:0005829 cytosol 2
Pathway
R-HSA-9612973 Autophagy 5 R-HSA-168256 Immune System 3 R-HSA-1266738 Developmental Biology 2
Partners
CALCOCO2CLCN3CLCN7GABARAPLAMP1NUFIP2RRAGARRAGB

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2012 Galectin-8 (LGALS8) acts as a cytosolic danger receptor that detects bacterial invasion by binding host glycans exposed on damaged Salmonella-containing vacuoles, and recruits the autophagy adaptor NDP52 (CALCOCO2) to activate antibacterial autophagy. Galectin-8-dependent NDP52 recruitment is transient and precedes ubiquitin-dependent NDP52 recruitment. Loss-of-function experiments in human cells, co-immunoprecipitation, fluorescence microscopy, Salmonella infection assays Nature High 22246322
2012 Galectin-8 monitors endosomal and lysosomal integrity by sensing luminal glycans that become exposed on the cytosolic face upon vesicle damage (sterile or pathogen-induced), functioning as a general sensor of endomembrane damage regardless of pathogen species (Salmonella, Listeria, Shigella). Fluorescence microscopy with glycan-binding domain mutants, infection with multiple pathogens, sterile lysosome-damaging agents Nature High 22246322
2017 Galectin-8 detects picornavirus-permeated endosomes and marks them for autophagic degradation (pore-activated clearance pathway); PLA2G16 counteracts this by facilitating viral genome translocation, placing LGALS8 upstream of autophagic clearance in a competition with viral escape. Genome-wide haploid genetic screen for suppressors of ΔPLA2G16 phenotype, epistasis analysis, infection assays Nature High 28077878
2018 Galectin-8 (LGALS8), upon lysosomal damage, inhibits MTOR and activates AMPK, thereby inducing autophagy. Intracellular galectins act as active signal transducers controlling master metabolic regulators rather than merely passive 'eat me' tags. Lysosomal damage assays, MTOR/AMPK activity measurements, galectin knockout/knockdown in cells, APEX2-based proximity proteomics Autophagy High 30081722
2016 Galectin-8 promotes pathological lymphangiogenesis through a molecular mechanism involving crosstalk among VEGF-C, podoplanin, and integrin pathways (α1β1 and α5β1). VEGFR-3 knockdown does not affect galectin-8-mediated lymphatic endothelial cell sprouting, placing integrins rather than VEGFR-3 as downstream effectors of galectin-8 in this context. Lgals8−/− and Pdpn−/− mouse models, corneal allograft transplantation, HSV keratitis model, siRNA knockdown of VEGFR-3 and integrins, LEC sprouting assays Nature Communications High 27066737
2019 CALCOCO2/NDP52 recruits the ULK and TBK1 kinase complexes to LGALS8-marked damaged Salmonella-containing vacuoles to initiate phagophore formation. CALCOCO2 forms a trimer with RB1CC1/FIP200 and TBKBP1/SINTBAD-AZI2/NAP1, linking galectin-8 danger sensing to de novo autophagy induction at cargo sites. Co-immunoprecipitation, dominant-negative and mutant constructs, fluorescence microscopy, autophagy induction assays in Salmonella-infected cells Autophagy High 31258038
2022 LGALS8/galectin-8 contributes to MTOR inactivation at damaged lysosomes via the Ragulator-RRAGA-RRAGB complex, acting together with NUFIP2; this function is governed by GABARAP and membrane Atg8ylation. Lysosome immunopurification (LysoIP), proteomics, MTOR activity assays, Atg8ylation-deficient mutants, fluorescence microscopy Autophagy High 36394332
2024 In human osteoclasts, galectin-8 regulates bone resorption, osteoclast nuclearity, and mTORC1 signaling. The short isoform is predominant for bone resorption. LC-MS/MS proteomic analysis identified 22 interacting partners shared by both isoforms; short-isoform-specific interactors include cell adhesion and lysosomal proteins. Interactions of galectin-8 with CLCN3, CLCN7, LAMP1, and LAMP2 (secretory vesicle proteins) were confirmed in human osteoclasts. Isoform-specific siRNA knockdown, LC-MS/MS proteomics in HEK293T cells, co-immunoprecipitation validation in human osteoclasts, bone resorption assays Life Science Alliance High 38395460
2020 A network of three miRNAs (miR-125b, miR-221, miR-579) concertedly downregulates LGALS8 expression in human macrophages upon Legionella pneumophila infection, thereby suppressing antibacterial immunity. LGALS8 downregulation facilitates Legionella replication, establishing LGALS8 as a component of the miRNA-controlled cell-autonomous immune network. miRNA profiling, ChIP-seq for histone acetylation, proteome analysis, miRNA overexpression/inhibition with intracellular bacterial replication readout in human macrophages mBio Medium 32209695
2024 IGF2BP2 regulates LGALS8 mRNA stability through m6A modification; LGALS8 deficiency severely impairs angiogenesis in vitro and leads to cerebrovascular dysplasia in vivo (zebrafish model). RNA-seq and MeRIP-seq, IGF2BP2 knockdown in endothelial cells, zebrafish vascular development assays, LGALS8 rescue experiments Frontiers in Neurology Medium 39722688
2017 Galectin-8 activates dendritic cells by promoting mature phenotype (increased MHCII, CD80, CD86 surface expression) and proinflammatory cytokine secretion (prominently IL-6). BMDCs from Lgals8-deficient mice show reduced CD86 and IL-6 and impaired ability to stimulate antigen-specific CD4 T cell activation, demonstrating an endogenous role of galectin-8 in DC activation. Bone marrow-derived DC cultures from Lgals8 knockout mice, flow cytometry, cytokine ELISA, antigen-specific T cell co-culture assays, in vivo FMDV challenge model Journal of Leukocyte Biology Medium 28811319
2025 Endogenous galectin-8 in the kidney does not protect against the acute phase of AKI but prevents maladaptive repair by regulating extracellular matrix homeostasis, limiting fibrosis (reduced collagen I/III deposition), and mitigating Th17 cell infiltration during the fibrotic phase. Lgals8−/− mouse model, folic acid-induced AKI, flow cytometry for immune cell profiling, histological assessment of fibrosis, RT-qPCR Molecular Medicine Medium 40375122
2015 CALCOCO2/NDP52 binds LGALS8/galectin-8 on damaged Salmonella-containing vacuoles via a distinct domain from that used for LC3C binding; this targeting function is separable from the maturation function of CALCOCO2 (which requires LC3A/B/GABARAPL2 and MYO6 binding). Domain mapping with deletion mutants, co-immunoprecipitation, fluorescence microscopy in Salmonella-infected cells Autophagy Medium 25998689
1996 PCTA-1 (LGALS8) encodes a secreted ~35 kDa protein sharing ~40% sequence homology with the N-terminal region of galectin family members; identified by surface-epitope masking and expression cloning from human LNCaP prostate cancer cells. Surface-epitope masking immunological subtraction, cDNA expression library screening, protein size determination Proceedings of the National Academy of Sciences USA Medium 8692978
2000 PCTA-1/LGALS8 maps to chromosomal locus 1q42-43 and is expressed as multiple isoforms at the mRNA level due to alternative splicing. Over-expression studies in cells were conducted to examine effects on cellular phenotype. Genomic mapping, RT-PCR isoform analysis, overexpression in cell lines Oncogene Low 10980616
2024 LGALS8 (galectin-8) inhibits MTOR and activates TFEB, driving ATG and lysosomal gene transcription in response to endomembrane damage. LGALS8-mediated ubiquitination recruits autophagy receptors (CALCOCO2, TRIM16, SQSTM1) upon lysosomal damage when ESCRT repair fails. Review/synthesis of mechanistic studies including MTOR activity assays, TFEB nuclear translocation assays, autophagy receptor recruitment experiments (cited from primary literature) Journal of Molecular Medicine Low 38183492
2024 In the context of hepatitis B virus infection, CALCOCO2/NDP52-mediated lysosomal degradation does NOT require LGALS8 (negative result), distinguishing anti-HBV autophagy from anti-bacterial xenophagy which depends on LGALS8. LGALS8-independent CALCOCO2 mutant analysis, ATG5 KO, RAB9-dependent pathway assays in HBV-infected cells Autophagy Medium 38752371

Source papers

Stage 0 corpus · 64 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature 844 22246324
2017 PLA2G16 represents a switch between entry and clearance of Picornaviridae. Nature 170 28077878
1996 Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family. Proceedings of the National Academy of Sciences of the United States of America 127 8692978
2018 Galectins control MTOR and AMPK in response to lysosomal damage to induce autophagy. Autophagy 123 30081722
2015 Humoral Immune Response against Nontargeted Tumor Antigens after Treatment with Sipuleucel-T and Its Association with Improved Clinical Outcome. Clinical cancer research : an official journal of the American Association for Cancer Research 109 25649018
2004 Tumor galectinology: insights into the complex network of a family of endogenous lectins. Glycoconjugate journal 106 15115907
2016 Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3. Nature communications 87 27066737
2002 Human galectin-8 isoforms and cancer. Glycoconjugate journal 85 14758080
2017 Frameshift indels introduced by genome editing can lead to in-frame exon skipping. PloS one 72 28570605
2016 Large-scale assessment of the gliomasphere model system. Neuro-oncology 72 27116978
2005 Discrimination between serous low malignant potential and invasive epithelial ovarian tumors using molecular profiling. Oncogene 72 15940270
2020 A risk signature with four autophagy-related genes for predicting survival of glioblastoma multiforme. Journal of cellular and molecular medicine 58 32065482
2001 Galectin-8: a complex sub-family of galectins (Review). International journal of molecular medicine 56 11494049
2009 Understanding Haemophilus parasuis infection in porcine spleen through a transcriptomics approach. BMC genomics 55 19196461
2014 Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta. Epigenetics 54 25437054
2000 Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene. Oncogene 51 10980616
2012 DNA methylation analysis of bone marrow cells at diagnosis of acute lymphoblastic leukemia and at remission. PloS one 36 22493696
2017 Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation. Journal of leukocyte biology 35 28811319
2024 PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy. Journal of molecular medicine (Berlin, Germany) 27 38183492
2018 Co-expression Analysis of Sirtuins and Related Metabolic Biomarkers in Juveniles of Gilthead Sea Bream (Sparus aurata) With Differences in Growth Performance. Frontiers in physiology 26 29922168
2022 Coronary artery plaque rupture and erosion: Role of wall shear stress profiling and biological patterns in acute coronary syndromes. International journal of cardiology 25 36343795
2017 Role of Galectins in Multiple Myeloma. International journal of molecular sciences 25 29258207
2015 Dual function of CALCOCO2/NDP52 during xenophagy. Autophagy 24 25998689
2022 Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage. Autophagy 23 36394332
2021 Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension. Science advances 23 34669463
2019 CALCOCO2/NDP52 initiates selective autophagy through recruitment of ULK and TBK1 kinase complexes. Autophagy 21 31258038
2014 Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer. Journal of translational medicine 21 24886063
2013 Identifying resistance mechanisms against five tyrosine kinase inhibitors targeting the ERBB/RAS pathway in 45 cancer cell lines. PloS one 20 23555683
2014 Alternative splicing in osteoclasts and Paget's disease of bone. BMC medical genetics 19 25115182
2005 Secretion of prostatic specific antigen, proliferative activity and androgen response in epithelial-stromal co-cultures from human prostate carcinoma. International journal of andrology 19 15679620
2024 Galectin-8 inhibition and functions in immune response and tumor biology. Medicinal research reviews 17 38613488
2019 Short communication: Inflammation, migration, and cell-cell interaction-related gene network expression in leukocytes is enhanced in Simmental compared with Holstein dairy cows after calving. Journal of dairy science 16 31837777
2021 LncRNA LGALS8-AS1 Promotes Breast Cancer Metastasis Through miR-125b-5p/SOX12 Feedback Regulatory Network. Frontiers in oncology 13 34745940
2016 mRNA Transcriptomics of Galectins Unveils Heterogeneous Organization in Mouse and Human Brain. Frontiers in molecular neuroscience 13 28018170
2001 Immunohistochemical expression of the intracellular component of galectin-8 in squamous cell metaplasia of the bronchial epithelium in neoplastic and benign processes. Pathology, research and practice 13 11795826
2024 Epigenetic footprints: Investigating placental DNA methylation in the context of prenatal exposure to phenols and phthalates. Environment international 12 38824843
2020 A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1. mBio 12 32209695
2019 Natural and synthetic pathogen associated molecular patterns modulate galectin expression in cow blood. Journal of animal science and technology 11 31602302
2024 Exploring the Role of Non-synonymous and Deleterious Variants Identified in Colorectal Cancer: A Multi-dimensional Computational Scrutiny of Exomes. Current genomics 10 38544823
2024 Inflammation-induced sialin mediates nitrate efflux in dysfunctional endothelium affecting NO bioavailability. Nitric oxide : biology and chemistry 10 38579899
2024 Chiral Pyclen-Based Heptadentate Chelates as Highly Stable MRI Contrast Agents. Inorganic chemistry 10 38642052
2024 Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions. Life science alliance 9 38395460
2023 Galectin-8 alters immune microenvironment and promotes tumor progression. American journal of cancer research 9 37424827
2021 Effect of source and amount of vitamin D on function and mRNA expression in immune cells in dairy cows. Journal of dairy science 8 34334204
2002 A candidate gene approach within the susceptibility region PCaP on 1q42.2-43 excludes deleterious mutations of the PCTA-1 gene to be responsible for hereditary prostate cancer. European urology 8 12234517
2022 Assessment of galectins -1, -3, -4, -8, and -9 expression in ovarian carcinoma patients with clinical implications. World journal of surgical oncology 7 36050693
2024 Activation of the lysosomal damage response and selective autophagy: the coordinated actions of galectins, TRIM proteins, and CGAS-STING1 in providing immunity against Mycobacterium tuberculosis. Critical reviews in microbiology 5 38470107
2023 Long non-coding RNA LGALS8-AS1 facilitates PLAGL2-mediated malignant phenotypes in gastric cancer. The journal of gene medicine 5 36807469
2025 Galectin-3 regulates erythropoiesis and enhances the immunoregulatory properties of CD71+ erythroid cells across developmental stages. Journal of immunology (Baltimore, Md. : 1950) 4 40119673
2023 Long noncoding RNA LGALS8-AS1 promotes angiogenesis and brain metastases in non-small cell lung cancer. Acta biochimica Polonica 4 37716002
2021 Transcriptomic Data Analysis Reveals a Down-Expression of Galectin-8 in Schizophrenia Hippocampus. Brain sciences 4 34439592
2020 The association between increasing levels of O-GlcNAc and galectins in the liver tissue of hibernating thirteen-lined ground squirrels (Ictidomys tridecemlineatus). Cell and tissue research 4 32157440
2022 Quantitative Proteomics Explore the Potential Targets and Action Mechanisms of Hydroxychloroquine. Molecules (Basel, Switzerland) 3 36014414
2025 Endogenous Galectin-8 protects against Th17 infiltration and fibrosis following acute kidney injury. Molecular medicine (Cambridge, Mass.) 2 40375122
2025 Multimerin1, not Galectin-8, Promotes Gastric Chief Cell Differentiation by Tempering WNT Signaling. bioRxiv : the preprint server for biology 1 41278970
2026 Hypoxia-induced LGALS8-AS1 sustains oxidative phosphorylation to drive breast cancer progression. Biochemical and biophysical research communications 0 41734713
2026 Multimerin1 and not Galectin-8 tempers WNT signaling to promote gastric chief cell differentiation. Scientific reports 0 41882123
2025 Mediators of the causal associations between protein ratios and ischemic stroke: a two-step Mendelian randomization study. Neurological research 0 40181221
2025 Shared hub genes in membranous nephropathy and kidney renal clear cell carcinoma: investigating molecular overlap and tumor progression. Discover oncology 0 40489038
2025 Integration of eQTL and GEO Datasets to Identify Genes Associated with Breast Ductal Carcinoma In Situ. Current issues in molecular biology 0 41020869
2024 CALCOCO2/NDP52 associates with RAB9 to initiate an antiviral response to hepatitis B virus infection through a lysosomal degradation pathway. Autophagy 0 38752371
2024 Citrus pectin modulates chicken peripheral blood mononuclear cell proteome in vitro. Poultry science 0 39288719
2024 Insulin like growth factor 2 mRNA binding protein 2 regulates vascular development in cerebral arteriovenous malformations. Frontiers in neurology 0 39722688
2023 Screening and Identifying Reference Genes for Erythrocyte Production from Cord Blood CD34+ Cells Exposed to Hypoxia. DNA and cell biology 0 38011643

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