Affinage

LARP7

La-related protein 7 · UniProt Q4G0J3

Length
582 aa
Mass
66.9 kDa
Annotated
2026-06-10
48 papers in source corpus 22 papers cited in narrative 24 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/8 claims corpus-supported (88%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LARP7 is a constitutive core component of the 7SK small nuclear ribonucleoprotein (snRNP) that functions as a negative regulator of RNA polymerase II transcriptional elongation by sequestering the positive elongation factor P-TEFb (PMID:18281698, PMID:18483487). It binds 7SK RNA directly through its La module (La motif plus RRM1), which tethers the 3'-terminal uridines, and a C-terminal extended RRM (xRRM) that clamps the apical loop of the 3' hairpin; together these contacts close 7SK into a stable conformation that joins the 5' and 3' ends and is a prerequisite for in vivo P-TEFb recruitment (PMID:23471002, PMID:25753663, PMID:29946027). Loss of LARP7 destabilizes 7SK, redistributes P-TEFb into the active super elongation complex, and elevates transcription—including Tat-dependent HIV-1 transcription and EMT-driving transcription factors that promote breast cancer invasion (PMID:18281698, PMID:25053741). Beyond elongation control, LARP7 acts as a bridging factor that loads spliceosomal U6 snRNA onto box C/D snoRNPs to direct U6 2'-O-methylation, ensuring splicing fidelity; ablation in the male germline causes defective U6 methylation, widespread splicing errors, and spermatogenic failure, and U6 methylation defects are seen in Alazami syndrome patient cells carrying a LARP7 mutation (PMID:32017896, PMID:32017898). LARP7 also participates in telomerase RNA biogenesis, binding and protecting telomerase RNA precursors to support maturation, telomerase activity, and telomere length (PMID:27766953, PMID:39009594). A distinct activity is allosteric enhancement of SIRT1 deacetylase activity through a C-terminal/SIRT1 N-terminal interaction, modulating acetylation of p53, NF-κB, and NLRP3 to control senescence and inflammasome-driven pyroptosis (PMID:34818543, PMID:41351020). Under DNA damage and oxidative stress, ATM activation triggers LARP7 ubiquitination and degradation, linking its loss to senescence, premature aging, and cardiac dysfunction (PMID:33663221, PMID:34818543). LARP7 can also undergo liquid-liquid phase separation upon HIV-1 infection, forming condensates that sequester Tat to restrain viral transcription (PMID:40113991).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2008 High

    Established LARP7 as a bona fide, constitutive subunit of the 7SK snRNP and a negative regulator of Pol II elongation, answering whether 7SK stability and P-TEFb sequestration depend on a dedicated protein.

    Evidence Glycerol gradient sedimentation, reciprocal immunodepletion, RNA-IP, and siRNA knockdown with P-TEFb and HIV-1 LTR transactivation readouts in human cells

    PMID:18281698 PMID:18483487

    Open questions at the time
    • Did not resolve the RNA elements or domains mediating binding
    • Mechanism by which LARP7 stabilizes 7SK left structural
  2. 2013 High

    Mapped the 7SK architecture of core snRNP assembly and showed LARP7 binding is upstream of P-TEFb recruitment, distinguishing an active assembly role from passive 7SK stabilization.

    Evidence In vivo RNA-protein interaction assays with deletion/mutation mapping and functional epistasis for P-TEFb recruitment

    PMID:23471002

    Open questions at the time
    • Atomic-resolution view of LARP7-7SK contacts not yet available
    • How MePCE and LARP7 cooperate structurally unresolved
  3. 2015 High

    Provided the structural basis for LARP7 recognition of 7SK, showing the La module tethers the 3' uridines and the xRRM clamps the 3' hairpin to close 7SK into a stable conformation.

    Evidence X-ray crystallography of the La module bound to 7SK 3' uridines, with footprinting and SAXS

    PMID:25753663

    Open questions at the time
    • High-resolution xRRM-RNA interface not yet captured
    • Dynamics of the closed conformation not addressed
  4. 2016 Medium

    Extended LARP7 function to telomere biology by linking it to telomerase enzymatic activity and telomere length maintenance in human cells.

    Evidence siRNA knockdown with TRAP telomerase activity assay and telomere length measurement in cancer cell lines

    PMID:27766953

    Open questions at the time
    • Direct binding to human telomerase RNA not demonstrated here
    • Step in telomerase biogenesis affected unresolved
  5. 2018 High

    Defined the high-resolution xRRM-7SK stem-loop 4 interface and the conserved telomerase-RNA-binding role of the LARP7 family, unifying 7SK and telomerase RNA recognition mechanisms.

    Evidence 2.2-Å crystallography, NMR dynamics and ITC for human xRRM; genetic deletion and Co-IP/RNA-IP for the fission yeast ortholog Lar7

    PMID:29422501 PMID:29946027

    Open questions at the time
    • Human telomerase complex structure not solved
    • How a single protein discriminates 7SK versus telomerase RNA in cells unclear
  6. 2020 High

    Revealed a 7SK-independent function: LARP7 bridges U6 snRNA to box C/D snoRNPs to direct U6 2'-O-methylation, establishing a role in splicing fidelity and connecting it to human disease.

    Evidence Conditional germline knockout with wild-type versus U6-loading-deficient rescue, 2'-O-methylation assays, RNA-seq splicing analysis, and Alazami syndrome patient cell analysis

    PMID:32017896 PMID:32017898

    Open questions at the time
    • Whether U6 loading and 7SK binding are mutually exclusive states unresolved
    • Mechanism of snoRNA subset selection not defined
  7. 2021 Medium

    Connected LARP7 stability to stress signaling, showing ATM-triggered ubiquitination and degradation of LARP7 dampens SIRT1 activity to drive senescence, aging, and cardiac failure.

    Evidence Cardiac-specific and global KO mice, AAV9 overexpression, ubiquitination assays, ATM inhibitor pharmacology, SIRT1 activity and acetylation assays

    PMID:33663221 PMID:34818543

    Open questions at the time
    • E3 ligase mediating LARP7 ubiquitination not identified
    • Whether SIRT1 regulation is independent of 7SK function unclear
  8. 2024 Medium

    Refined LARP7's telomerase role to RNA precursor maturation, placing LARP7/MePCE as positive factors converting 3'-extended hTR into mature RNA.

    Evidence Biochemical fractionation, RNA-IP, LARP7/MePCE depletion, telomerase activity and telomere length assays

    PMID:39009594

    Open questions at the time
    • Enzymatic steps of hTR 3' processing not resolved
    • Coordination with nuclear/cytoplasmic trafficking unclear
  9. 2024 Medium

    Identified a meiotic chromatin-silencing function, showing LARP7 localizes to the XY body and is required for meiotic sex chromosome inactivation in spermatocytes.

    Evidence Germline-specific conditional KO, immunofluorescence localization, RNA-seq, and ChIP for histone marks in mouse spermatocytes

    PMID:39637191

    Open questions at the time
    • Whether MSCI role reflects 7SK/elongation control or a distinct mechanism unresolved
    • Direct chromatin recruitment mechanism unknown
  10. 2025 Medium

    Resolved a mechanism for direct viral restraint, showing LARP7 phase separates upon HIV-1 infection to sequester Tat via IDR lysines.

    Evidence Live-cell imaging of condensates, lysine mutagenesis, and Tat-dependent transcription assays

    PMID:40113991

    Open questions at the time
    • Trigger linking infection to phase separation not defined
    • Relationship between condensate and canonical 7SK snRNP unclear
  11. 2025 Medium

    Defined the LARP7-SIRT1 interaction at domain resolution and a downstream NLRP3 deacetylation axis controlling inflammasome activation.

    Evidence Domain-mapping Co-IP, proximity ligation, acetyl-proteomics mapping NLRP3 sites, and neuron-specific KO mice after ischemic stroke

    PMID:41351020

    Open questions at the time
    • Structural basis of allosteric SIRT1 enhancement not solved
    • Whether this is independent of nuclear 7SK functions unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How LARP7 partitions among its distinct roles—7SK/P-TEFb control, U6 methylation, telomerase maturation, SIRT1 modulation, and phase separation—within a cell, and what determines which function dominates in a given context, remains unresolved.
  • No unified model integrating nuclear RNP roles with cytoplasmic SIRT-axis functions
  • Regulatory switches between functions not identified
  • Structural basis of SIRT1 enhancement and condensate assembly not determined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 5 GO:0140110 transcription regulator activity 3 GO:0060090 molecular adaptor activity 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 2 GO:0000228 nuclear chromosome 1
Pathway
R-HSA-74160 Gene expression (Transcription) 3 R-HSA-8953854 Metabolism of RNA 3 R-HSA-1643685 Disease 2
Partners
HEXIM1MCTS1MEPCEP-TEFBSIRT1SIRT6STING
Complex memberships
7SK snRNPtelomerase complex

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 LARP7 is a stable, constitutive component of the 7SK snRNP that binds 7SK RNA directly; immunodepletion of LARP7 co-depletes most 7SK RNA regardless of P-TEFb, HEXIM1, or hnRNP A1 association status. siRNA knockdown of LARP7 decreased steady-state 7SK levels, increased free P-TEFb, and increased Tat transactivation of the HIV-1 LTR. Glycerol gradient sedimentation, immunodepletion, siRNA knockdown with functional readouts (P-TEFb levels, HIV-1 LTR transactivation) Nucleic acids research High 18281698
2008 LARP7 binds the highly conserved 3'-terminal U-rich stretch of 7SK RNA and is an integral part of the 7SK RNP. Upon transcriptional stimulation, LARP7 remains associated with 7SK RNA while P-TEFb is released. RNAi-mediated reduction of LARP7 enhances transcription from cellular Pol II promoters and from a TAT-dependent HIV-1 promoter, identifying LARP7 as a negative transcriptional regulator acting through the 7SK RNP. RNA immunoprecipitation, RNAi knockdown, reporter transcription assays EMBO reports High 18483487
2013 In vivo RNA-protein interaction assays mapped the 7SK elements required for core snRNP assembly: MePCE interacts with the 5'-terminal G1-U4/U106-G111 helix-tail motif, while Larp7 binds the 3'-terminal hairpin and the following U-rich tail of 7SK. Binding of Larp7 to 7SK is a prerequisite for in vivo recruitment of P-TEFb, indicating Larp7 directly participates in P-TEFb regulation beyond merely stabilizing 7SK. In vivo RNA-protein interaction assays, deletion/mutation mapping Nucleic acids research High 23471002
2015 Crystal structure of the LARP7 La module (La motif + RRM1) bound to 3'-terminal uridines of 7SK reveals that the penultimate uridine is tethered by both domains. The RRM1 of LARP7 is smaller and more exposed than in canonical La protein. A second C-terminal RRM (xRRM) binds the apical loop of the 3' hairpin of 7SK while the N-terminal La module binds at its foot; together they stabilize 7SK in a closed structure joining 5'-end conserved sequences with the 3' hairpin foot. X-ray crystallography, binding assays, footprinting, small-angle X-ray scattering (SAXS) Nucleic acids research High 25753663
2014 Decreased levels of LARP7 and 7SK snRNA redistribute P-TEFb to the transcriptionally active super elongation complex, resulting in P-TEFb activation and increased transcription of EMT transcription factors (Slug, FOXC2, ZEB2, Twist1), promoting breast cancer EMT, invasion, and metastasis. siRNA knockdown, gene expression analysis, invasion/migration assays, ChIP eLife Medium 25053741
2018 2.2-Å X-ray crystal structure of the human Larp7 xRRM bound to 7SK stem-loop 4 reveals a unique binding interface. The xRRM is preordered to bind a flexible RNA loop 4. Mutagenesis combined with isothermal titration calorimetry quantified the contribution of individual contacts. The La module and xRRM together define a structural model for Larp7 binding to the 7SK 3' end and mechanism for 7SK RNP assembly. X-ray crystallography (2.2 Å), NMR 13C spin relaxation, isothermal titration calorimetry, mutagenesis Proceedings of the National Academy of Sciences of the United States of America High 29946027
2018 LARP7 family protein Lar7 (fission yeast ortholog) binds telomerase RNA via conserved RNA-recognition motifs to protect it from exosomal degradation, stabilizes the association of telomerase RNA with the LSm2-8 complex and telomerase reverse transcriptase, remains a component of the mature telomerase complex, and is required for telomerase localization to the telomere. Genetic deletion, co-immunoprecipitation, RNA immunoprecipitation, telomere localization assays in S. pombe Nature communications Medium 29422501
2016 Depletion of human LARP7 by siRNA reduced telomerase enzymatic activity and caused progressively shorter telomeres in human cancer cell lines, demonstrating a role for LARP7 in maintaining telomerase activity and telomere length in human cells. siRNA knockdown, TRAP telomerase activity assay, telomere length measurement BMC genomics Medium 27766953
2020 LARP7 functions as a critical cofactor for 2'-O-methylation of U6 snRNA in mouse male germ cells by promoting U6 loading onto box C/D snoRNP. Ablation of LARP7 in the male germline causes defective U6 2'-O-methylation, massive alterations in pre-mRNA splicing, and spermatogenic failure; these defects were rescued by wild-type LARP7 but not by a U6-loading-deficient LARP7 mutant. Conditional knockout, rescue experiments with wild-type vs. mutant LARP7, 2'-O-methylation assays, RNA-seq splicing analysis Molecular cell High 32017896
2020 LARP7 physically connects spliceosomal U6 snRNA with a distinct subset of box C/D snoRNAs guiding U6 2'-O-methylation; depletion of LARP7 severely compromises these specific U6 2'-O-methylations and perturbs alternative splicing. Defects in U6 2'-O-methylation were also identified in Alazami syndrome patient cells carrying a LARP7 mutation. Co-immunoprecipitation, RNA immunoprecipitation, 2'-O-methylation profiling, RNA-seq, patient-derived cell analysis Molecular cell High 32017898
2021 Reactive oxygen species activate ATM, which triggers LARP7 ubiquitination and degradation in failing cardiomyocytes. Cardiac-specific LARP7 knockout causes defective mitochondrial biogenesis, impaired oxidative phosphorylation, elevated oxidative stress, and heart failure, accompanied by reduced SIRT1 stability and deacetylase activity that impairs SIRT1-mediated transcription of OXPHOS and energy metabolism genes. Cardiac-specific and global KO mice, AAV9-mediated overexpression, co-immunoprecipitation, ATM inhibitor pharmacology, ubiquitination assay Circulation Medium 33663221
2021 DNA damage-mediated ATM activation triggers extracellular shuttling and downregulation of LARP7, which dampens SIRT1 deacetylase activity, enhances p53 and NF-κB (p65) transcriptional activity via increased acetylation, and accelerates cellular senescence. Deletion of LARP7 in rodents leads to senescent cell accumulation and premature aging. LARP7 knockout rodent model, acetylation assays, SIRT1 activity assay, co-immunoprecipitation, senescence markers Cell reports Medium 34818543
2019 The Legionella effector AnkH interacts with nuclear LARP7 (component of the 7SK snRNP), partially impeding interactions of 7SK snRNP components with LARP7 and interfering with Pol II transcriptional elongation. A substitution in the β-hairpin loop of the third ankyrin repeat of AnkH diminishes LARP7-AnkH interaction and phenocopies the ankH null mutant defect in intracellular growth. Co-immunoprecipitation, crystal structure of AnkH, site-directed mutagenesis, LARP7 knockdown in host cells, bacterial intracellular growth assay mBio Medium 31455655
2024 LARP7 interacts with SIRT6 to maintain its expression; LARP7 depletion disrupts this interaction and decreases SIRT6 levels. Additionally, YTHDF2-mediated m6A-dependent degradation of Larp7 mRNA under combined cadmium/high-fat diet exposure reduces LARP7 protein, contributing to hippocampal neuronal senescence. Co-immunoprecipitation, RNA immunoprecipitation, siRNA knockdown, RNA stability assays, LARP7 overexpression Journal of hazardous materials Low 39002485
2024 LARP7 and MePCE bind an early 3'-extended precursor form of human telomerase RNA (hTR); their depletion inhibits conversion of the 3'-extended short form into mature hTR and causes cytoplasmic accumulation of hTR and telomere shortening, placing LARP7/MePCE as positive factors in hTR maturation and processing. Biochemical fractionation, RNA immunoprecipitation, LARP7/MePCE depletion, telomere length assays, telomerase activity assays Nature communications Medium 39009594
2022 MCTS1 interacts with LARP7 (confirmed by Co-IP), predominantly in the cytoplasm. MCTS1 increases LARP7 protein half-life and reduces its poly-ubiquitination, stabilizing LARP7 protein via protection from proteasomal degradation. Co-immunoprecipitation, cycloheximide chase assay, ubiquitination Co-IP Clinical and experimental pharmacology & physiology Low 35274760
2024 Under high-glucose conditions, LARP7 translocates from the nucleus to the cytoplasm where it interacts with accumulated STING protein to inhibit STING's degradation via the autophagy-lysosomal pathway, thereby promoting cardiomyocyte fibrosis and apoptosis in diabetic cardiomyopathy. Co-immunoprecipitation, subcellular fractionation/immunofluorescence, adenovirus-mediated knockdown/overexpression, autophagy flux assays Frontiers in bioscience (Landmark edition) Low 39082350
2025 LARP7's C-terminal domain interacts with the N-terminal domain of SIRT1 to enhance SIRT1 deacetylase activity; SIRT1 then deacetylates NLRP3 at K21/K22/K24, inhibiting inflammasome assembly and neuronal pyroptosis after ischemic stroke. Co-immunoprecipitation, proximity ligation assay, domain deletion analysis, acetyl-proteomics, neuron-specific KO mice Journal of neuroinflammation Medium 41351020
2023 Crystal structure (and NMR) of Tetrahymena p65 (LARP7 ortholog) with telomerase RNA reveals three previously unknown helices: one in the NTD binding the La module, one extending RRM1, and one preceding xRRM. The extended La module (αN, LaM, RRM1) interacts with four 3' terminal U nucleotides; LaM and αN additionally interact with TER pseudoknot, stem 1, and the 5' end, revealing extensive p65-TER contacts promoting TER folding and core RNP assembly. Cryo-EM focused classification, NMR spectroscopy, structural analysis Journal of molecular biology High 37330293
2025 HIV-1 infection triggers liquid-liquid phase separation of LARP7, forming condensates that sequester Tat. Conserved lysine residues in the intrinsically disordered region of LARP7 are essential for both phase separation and inhibition of Tat-mediated transcription, thereby restraining HIV-1 replication. Live-cell imaging of LARP7 condensates, site-directed mutagenesis of lysine residues, Tat-dependent transcription assays EMBO reports Medium 40113991
2024 LARP7 is required for meiotic sex chromosome inactivation (MSCI) in mouse spermatocytes. LARP7 localizes to the XY body in spermatocytes, and germline-specific Larp7 deletion results in spermatogenic arrest, persistent transcription of sex chromosome genes, accumulation of H4K12ac, and loss of H3K9me2 at the XY body, indicating a role in epigenetic chromatin silencing during meiosis. Germline-specific conditional KO, immunofluorescence localization, RNA-seq, ChIP for histone marks PloS one Medium 39637191
2026 LARP7 promotes G2/M phase transition in cardiomyocytes by suppressing p21 via the SIRT1/p53 pathway, thereby elevating CDK1/CCNB activity and extending the neonatal heart regenerative window. Co-expression of LARP7 with CCND1/CDK4 via dual AAV9 markedly boosted cardiac regeneration after injury. AAV9-mediated overexpression, cell cycle analysis, SIRT1/p53/p21/CDK1 pathway analysis, cardiac injury model Journal of molecular and cellular cardiology Low 41667032
2025 In Drosophila, loss of Larp7 or 7SK RNA impairs locomotion and reduces axonal growth at neuromuscular junctions. Larp7 functions autonomously in specific motoneurons to promote axogenesis. Reducing P-TEFb abundance partially rescues the locomotion and axonal growth defects, placing Larp7 upstream of P-TEFb in this transcriptional regulatory pathway in neurons. Genetic deletion in Drosophila, neuromuscular junction morphology analysis, locomotion assays, genetic epistasis with P-TEFb reduction, transcriptomic analysis of mutant motoneurons bioRxivpreprint Medium
2025 HEXIM1 and LARP7 promote replication fork slowing and RAD51-mediated replication fork reversal in response to agents that cause both replication and transcription stress (e.g., camptothecin, BET inhibitors), and support homologous recombination at direct DSBs. This role is not required for HR in response to hydroxyurea (replication stress without transcription stress), and 7SK snRNP components are not recruited to stressed replication forks; RNA Pol II inhibition phenocopies their loss. siRNA knockdown of LARP7/HEXIM1, replication fork fiber assays, RAD51 foci quantification, HR reporter assays, Pol II inhibitor epistasis bioRxivpreprint Medium

Source papers

Stage 0 corpus · 48 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated. Nucleic acids research 207 18281698
2008 The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes. EMBO reports 150 18483487
2021 LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. Circulation 104 33663221
2021 LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity. Cell reports 91 34818543
2012 Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism. Human mutation 70 22865833
2014 LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. eLife 67 25053741
2013 RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP. Nucleic acids research 55 23471002
2015 Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7. Nucleic acids research 54 25753663
2020 LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice. Molecular cell 53 32017896
2020 The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness. Molecular cell 52 32017898
2018 Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7. Proceedings of the National Academy of Sciences of the United States of America 52 29946027
2012 LARP7 is a potential tumor suppressor gene in gastric cancer. Laboratory investigation; a journal of technical methods and pathology 52 22488152
2018 LARP7 family proteins have conserved function in telomerase assembly. Nature communications 38 29422501
2019 Interaction of the Ankyrin H Core Effector of Legionella with the Host LARP7 Component of the 7SK snRNP Complex. mBio 36 31455655
2018 LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast. Nature communications 35 29422503
2016 Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency. BMC genomics 31 27766953
2015 Broadening the phenotypic spectrum of pathogenic LARP7 variants: two cases with intellectual disability, variable growth retardation and distinct facial features. Journal of human genetics 25 26607181
2015 Compound heterozygous variants in the LARP7 gene as a cause of Alazami syndrome in a Caucasian female with significant failure to thrive, short stature, and developmental disability. American journal of medical genetics. Part A 23 26374271
2015 CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart. Journal of cell science 19 26542022
2020 Stabilize and connect: the role of LARP7 in nuclear non-coding RNA metabolism. RNA biology 18 32401147
2018 Novel compound heterozygous variants in the LARP7 gene in a patient with Alazami syndrome. Human genome variation 17 29619239
2018 LARP7 in papillary thyroid carcinoma induces NIS expression through suppression of the SHH signaling pathway. Molecular medicine reports 15 29620212
2016 Unraveling the conformational determinants of LARP7 and 7SK small nuclear RNA by theoretical approaches. Molecular bioSystems 14 27301448
2025 Glucose-regulating hydrogel for immune modulation and angiogenesis through metabolic reprogramming and LARP7-SIRT1 pathway in infected diabetic wounds. Biomaterials 12 39951832
2020 Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins. RNA biology 11 33131423
2023 Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR. Journal of molecular biology 9 37330293
2024 Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition. Journal of hazardous materials 8 39002485
2022 MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability. Clinical and experimental pharmacology & physiology 7 35274760
2022 Involvement of LARP7 in Activation of SIRT1 to Inhibit NF-κB Signaling Protects Microglia from Acrylamide-Induced Neuroinflammation. Neurotoxicity research 6 36550222
2020 Compound Phenotype Due to Recessive Variants in LARP7 and OTOG Genes Disclosed by an Integrated Approach of SNP-Array and Whole Exome Sequencing. Genes 6 32244554
2020 Novel Mutation in LARP7 in Two Iranian Consanguineous Families with Syndromic Intellectual Disability and Facial Dysmorphism. Archives of Iranian medicine 6 33356342
2024 LARP3, LARP7, and MePCE are involved in the early stage of human telomerase RNA biogenesis. Nature communications 5 39009594
2024 Exome Sequencing Detects Uniparental Disomy of Chromosome 4 Revealing a LARP7 Pathogenic Variant Responsible for Alazami Syndrome: A Case Report. American journal of medical genetics. Part A 4 39417555
2020 The Interlocking Lives of LARP7: Fine-Tuning Transcription, RNA Modification, and Splicing through Multiple Non-coding RNAs. Molecular cell 4 32243831
2023 LARP7 alleviates psoriasis symptoms in mice by regulating the SIRT1/NF-κB signaling pathway. Allergologia et immunopathologia 3 36617833
2025 Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors. Translational oncology 2 39933393
2025 Liquid-liquid phase separation of LARP7 restrains HIV-1 replication. EMBO reports 2 40113991
2025 Alazami syndrome with a single LARP7 variant and concurrent osteo-oto-hepato-enteric syndrome: A case of complex genetic interplay. Radiology case reports 2 40129845
2024 LARP7 Contributes to Glucose-Induced Cardiac Dysfunction, Apoptosis and Fibrosis by Inhibiting the Degradation of STING. Frontiers in bioscience (Landmark edition) 2 39082350
2025 Functional Characterization of Variants in LARP7: Report of Three New Individuals With Alazami Syndrome and a Literature Review. Human mutation 1 40548259
2024 LARP7 is required for sex chromosome silencing during meiosis in mice. PloS one 1 39637191
2023 [Clinical and genetic analysis of a child with Alazami syndrome due to compound heterozygous variants of LARP7 gene]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 1 37368391
2023 LARP7 upregulates SIRT1 deacetylase activity and inhibits Th1/Th17 cytokine response in psoriatic mice. Allergologia et immunopathologia 1 37937491
2026 LARP7 promotes postnatal cardiac regeneration by facilitating G2/M phase transition. Journal of molecular and cellular cardiology 0 41667032
2026 Expanding the phenotypic and immunological landscape of Alazami syndrome: Evidence from seven new patients with LARP7 gene variants. European journal of pediatrics 0 41811398
2026 LARP7 enhances the potential of dental pulp stem cells to promote peripheral nerve repair. Stem cells (Dayton, Ohio) 0 41812059
2025 Liraglutide Attenuates Endothelial Dysfunction by Inhibiting Hyperglycemia-Induced Endothelial Cell Senescence Through the LARP7/SIRT1 Pathway. Archivum immunologiae et therapiae experimentalis 0 41343751
2025 LARP7 protects against ischemic brain injury by modulating NLRP3 deacetylation to suppress neuronal pyroptosis. Journal of neuroinflammation 0 41351020

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