Affinage

LARP7

La-related protein 7 · UniProt Q4G0J3

Length
582 aa
Mass
66.9 kDa
Annotated
2026-04-28
48 papers in source corpus 23 papers cited in narrative 25 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LARP7 is a multifunctional RNA-binding protein that serves as a constitutive scaffold of the 7SK small nuclear ribonucleoprotein (snRNP), a negative regulator of RNA Polymerase II transcriptional elongation, and a bridging factor for RNA modification and telomerase biogenesis. Through its N-terminal La module and C-terminal xRRM domain, LARP7 binds the 3'-terminal U-rich tail and stem-loop 4 of 7SK snRNA, stabilizing 7SK levels and enabling sequestration of P-TEFb in an inactive complex; loss of LARP7 releases P-TEFb, enhancing Pol II Ser2 phosphorylation and transcription of target genes including EMT transcription factors and HIV-1 (PMID:18281698, PMID:18483487, PMID:25053741, PMID:29946027). Independent of 7SK, LARP7 physically connects U6 snRNA to box C/D snoRNPs to guide 2'-O-methylation essential for proper pre-mRNA splicing, promotes early processing and nuclear retention of human telomerase RNA (hTR), and allosterically enhances SIRT1 deacetylase activity through direct C-terminal domain interaction, thereby modulating p53/NF-κB acetylation, inflammasome assembly, senescence, and cardiac function (PMID:32017898, PMID:32017896, PMID:39009594, PMID:34818543, PMID:33663221, PMID:41351020). Loss-of-function mutations in LARP7 cause Alazami syndrome, associated with short telomeres and defective U6 2'-O-methylation (PMID:27766953, PMID:32017898).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2008 High

    Establishing LARP7 as a constitutive 7SK snRNP component resolved how 7SK RNA stability is maintained and linked LARP7 directly to P-TEFb regulation and Pol II transcriptional control.

    Evidence Glycerol gradient sedimentation, immunodepletion, siRNA knockdown with Tat transactivation and transcription reporter assays in human cells (two independent labs)

    PMID:18281698 PMID:18483487

    Open questions at the time
    • Mechanism by which LARP7 facilitates HEXIM1 and P-TEFb recruitment was unresolved
    • Whether LARP7 has functions beyond 7SK was unknown
  2. 2013 High

    Mapping LARP7's binding to the 7SK 3' hairpin and U-tail and showing this binding is a prerequisite for P-TEFb recruitment demonstrated that LARP7 is not merely a passive stabilizer but actively participates in RNP assembly.

    Evidence In vivo RNA-protein interaction assays with systematic 7SK RNA mutagenesis

    PMID:23471002

    Open questions at the time
    • Atomic-resolution structural basis for LARP7-7SK interaction was not yet available
    • How LARP7 binding triggers conformational changes enabling P-TEFb capture was unknown
  3. 2015 High

    Crystal structures of the LARP7 La module bound to 7SK 3' uridines and the demonstration that N- and C-terminal domains jointly stabilize a closed 7SK structure provided the first atomic-level model of how LARP7 organizes the 7SK snRNP.

    Evidence X-ray crystallography, SAXS, binding and footprinting assays

    PMID:25753663

    Open questions at the time
    • Structure of the C-terminal xRRM bound to stem-loop 4 was not yet determined
    • How the full-length protein engages the complete 7SK was modeled but not resolved
  4. 2014 High

    Demonstrating that LARP7 depletion redistributes P-TEFb to super elongation complexes and upregulates EMT transcription factors established a concrete biological consequence—breast cancer invasion and metastasis—of 7SK/P-TEFb deregulation.

    Evidence siRNA knockdown and overexpression with invasion/migration assays and gene expression analysis in breast cancer cells

    PMID:25053741

    Open questions at the time
    • Whether LARP7 loss is causal in human tumors versus a correlate was not established
    • Contribution of non-7SK functions of LARP7 to the cancer phenotype was not assessed
  5. 2015 Medium

    Zebrafish epistasis experiments placed Larp7 upstream of Cdk9/P-TEFb-mediated Pol II Ser2 phosphorylation in cardiomyocyte proliferation, extending the transcriptional control axis to cardiac development.

    Evidence Morpholino knockdown in zebrafish with epistasis analysis and Pol II CTD phosphorylation readouts

    PMID:26542022

    Open questions at the time
    • Morpholino-based evidence in zebrafish; genetic mutant confirmation was not provided
    • Mammalian cardiac relevance was not yet demonstrated
  6. 2016 Medium

    Linking LARP7 to telomerase activity and demonstrating very short telomeres in Alazami syndrome patients expanded LARP7's functional repertoire beyond transcriptional regulation to telomere maintenance.

    Evidence siRNA knockdown with TRAP telomerase assay and telomere length measurement in human cells and patient lymphocytes

    PMID:27766953

    Open questions at the time
    • Direct mechanism by which LARP7 supports human telomerase RNA (hTR) was unclear
    • Whether the telomere defect is independent of 7SK-mediated transcription changes was not resolved
  7. 2018 High

    A high-resolution crystal structure of the human LARP7 xRRM bound to 7SK stem-loop 4, combined with NMR dynamics, completed the structural picture of how LARP7's two RNA-binding domains jointly recognize and stabilize 7SK snRNA.

    Evidence 2.2 Å X-ray crystallography, NMR ¹³C spin relaxation, ITC, and mutagenesis

    PMID:29946027

    Open questions at the time
    • Full-length LARP7-7SK RNP structure remained unresolved
    • How structural changes propagate to HEXIM1/P-TEFb recruitment was mechanistically undetermined
  8. 2018 High

    Studies of fission yeast LARP7 orthologs (Lar7/Pof8) demonstrated that the conserved xRRM domain promotes telomerase RNA stability and TERT assembly, establishing an evolutionarily conserved function in telomerase biogenesis.

    Evidence Genetic deletion and domain mutagenesis with RNA-protein interaction and telomere localization assays in S. pombe

    PMID:29422501 PMID:29422503

    Open questions at the time
    • Whether human LARP7 uses the same xRRM-dependent mechanism for hTR was not directly shown
    • How LARP7 transitions between 7SK and telomerase RNA targets was unknown
  9. 2019 Medium

    Identification of the Legionella effector AnkH as a nuclear interactor of LARP7 that partially disrupts 7SK snRNP assembly revealed that pathogens exploit LARP7-mediated transcriptional control for intracellular replication.

    Evidence Co-immunoprecipitation, crystal structure of AnkH, site-directed mutagenesis, and bacterial intracellular growth assays

    PMID:31455655

    Open questions at the time
    • Precise mechanism by which AnkH disrupts LARP7-7SK contacts was not fully defined
    • Whether additional host targets of AnkH contribute to the phenotype was not excluded
  10. 2020 High

    Two concurrent studies demonstrated that LARP7 bridges U6 snRNA to box C/D snoRNPs for 2'-O-methylation, establishing a second major RNA chaperone function; LARP7 loss causes widespread splicing defects, and Alazami syndrome patients show defective U6 modification.

    Evidence Co-immunoprecipitation, RNA modification analysis, transcriptome-wide splicing analysis in human cells and patient samples; conditional KO mouse with domain-specific rescue

    PMID:32017896 PMID:32017898

    Open questions at the time
    • How LARP7 simultaneously manages 7SK and U6 RNA clients was not resolved
    • Whether all Alazami syndrome pathology traces to U6 modification versus telomerase or P-TEFb defects was unclear
  11. 2021 High

    Discovery that LARP7 allosterically activates SIRT1 deacetylase activity uncovered a direct protein-protein mechanism outside RNA biology, linking LARP7 loss to p53/NF-κB hyperacetylation, senescence, and heart failure; ATM-mediated ubiquitination of LARP7 creates a damage-responsive feedback loop.

    Evidence Cardiac-specific and global KO mice, SIRT1 enzymatic activity assays, acetylation analysis of p53/NF-κB, senescence assays, ATM inhibitor rescue

    PMID:33663221 PMID:34818543

    Open questions at the time
    • Whether SIRT1 activation by LARP7 is fully independent of 7SK/P-TEFb was not formally demonstrated
    • Structural basis of the LARP7-SIRT1 interaction was not determined
  12. 2023 High

    Cryo-EM/NMR structure of full-length Tetrahymena LARP7 (p65) in the telomerase complex revealed three previously unknown helices and expanded contacts with telomerase RNA beyond the 3' tail, providing the most complete structural view of how LARP7 family proteins organize a catalytic RNP.

    Evidence Cryo-EM focused classification and NMR spectroscopy of Tetrahymena p65 within telomerase

    PMID:37330293

    Open questions at the time
    • Human LARP7 full-length structure in any RNP context remains undetermined
    • Whether the additional helices are conserved in vertebrate LARP7 is untested
  13. 2024 Medium

    Biochemical dissection of human telomerase RNA biogenesis showed LARP7 and MePCE bind 3'-extended hTR precursors and promote their maturation and nuclear retention, directly explaining LARP7's role in telomerase activity and telomere maintenance.

    Evidence Biochemical fractionation, RNA binding assays, depletion experiments, and telomere length assays in human cells

    PMID:39009594

    Open questions at the time
    • Whether LARP7 escorts hTR through specific nuclear compartments was not resolved
    • Contribution of MePCE versus LARP7 to individual biogenesis steps was not fully disentangled
  14. 2024 Medium

    LARP7 was shown to be required for meiotic sex chromosome inactivation (MSCI), localizing to the XY body and maintaining repressive chromatin marks, revealing a chromatin-regulatory role during spermatogenesis.

    Evidence Germline-specific Larp7 KO mice, immunofluorescence, histone modification and transcriptional analysis

    PMID:39637191

    Open questions at the time
    • Whether MSCI function depends on 7SK/P-TEFb sequestration or a distinct mechanism was not determined
    • No direct biochemical link between LARP7 and the MSCI silencing machinery was established
  15. 2025 Medium

    Discovery that LARP7 undergoes liquid-liquid phase separation upon HIV-1 infection, sequestering P-TEFb and Tat in condensates through IDR lysine residues, revealed a biophysical mechanism for LARP7's antiviral function.

    Evidence Live cell imaging, IDR lysine mutagenesis, Tat-mediated transcription assays

    PMID:40113991

    Open questions at the time
    • Whether LARP7 phase separation occurs in non-HIV contexts was not explored
    • In vivo relevance for HIV-1 latency control was not demonstrated
  16. 2025 Medium

    Domain mapping of the LARP7-SIRT1 interaction (LARP7 C-terminal domain to SIRT1 N-terminal domain) and identification of NLRP3 K21/K22/K24 as SIRT1 deacetylation targets established a molecular pathway from LARP7 to inflammasome suppression and neuroprotection after ischemic stroke.

    Evidence Co-immunoprecipitation with domain deletions, proximity ligation assay, acetyl-proteomics, neuron-specific LARP7 KO mice

    PMID:41351020

    Open questions at the time
    • Structural basis for allosteric SIRT1 activation by LARP7 C-terminal domain is unknown
    • Whether LARP7 regulates other SIRT1 substrates genome-wide was not assessed

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the structure of human full-length LARP7 in any RNP context; how LARP7 partitions among its distinct RNA clients (7SK, U6, hTR); whether SIRT1 activation is mechanistically separable from 7SK/P-TEFb regulation; and the relative contributions of each LARP7 function to Alazami syndrome pathology.
  • No human full-length LARP7 structure in any RNP complex
  • Client RNA partitioning mechanism unknown
  • Relative disease contribution of individual LARP7 functions not deconvolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 11 GO:0098772 molecular function regulator activity 3 GO:0060090 molecular adaptor activity 2
Localization
GO:0005634 nucleus 4 GO:0005829 cytosol 2
Pathway
R-HSA-74160 Gene expression (Transcription) 5 R-HSA-8953854 Metabolism of RNA 3 R-HSA-1640170 Cell Cycle 2 R-HSA-8953897 Cellular responses to stimuli 2
Partners
CDK9HEXIM1MCTS1MEPCESIRT1SIRT6STING
Complex memberships
7SK snRNPtelomerase RNP

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 LARP7 is a stable, core component of the 7SK snRNP that binds 7SK snRNA and is required for maintaining steady-state 7SK levels; immunodepletion of LARP7 co-depletes 7SK regardless of P-TEFb, HEXIM1, or hnRNP A1 association, and siRNA knockdown of LARP7 decreases 7SK levels, increases free P-TEFb, and increases Tat transactivation of HIV-1 LTR. Glycerol gradient sedimentation, immunodepletion, siRNA knockdown with functional readouts (P-TEFb levels, Tat transactivation assay) Nucleic acids research High 18281698
2008 LARP7 binds the highly conserved 3'-terminal U-rich stretch of 7SK RNA, is an integral part of the 7SK RNP, remains associated with 7SK upon P-TEFb release, and acts as a negative transcriptional regulator of RNA Pol II genes through the 7SK RNP system; siRNA-mediated reduction of LARP7 enhances transcription from cellular Pol II promoters and the TAT-dependent HIV-1 promoter. Co-immunoprecipitation, RNA interference, transcription reporter assays EMBO reports High 18483487
2013 Larp7 binds to the 3'-terminal hairpin and following U-rich tail of 7SK snRNA, and MePCE interacts with the 5'-terminal helix-tail motif; binding of Larp7 to 7SK is a prerequisite for in vivo recruitment of P-TEFb to the 7SK snRNP, indicating Larp7 directly participates in P-TEFb regulation beyond merely stabilizing 7SK. In vivo RNA-protein interaction assays, mutational analysis of 7SK RNA elements Nucleic acids research High 23471002
2015 Crystal structure of the LARP7 La module (La motif + RRM1) bound to 3'-terminal uridines of 7SK shows the penultimate uridine is tethered by both domains; a second C-terminal RRM domain binds the apical loop of the 7SK 3' hairpin, and together the N- and C-terminal domains stabilize 7SK in a closed structure by joining conserved 5'-end sequences with the foot of the 3' hairpin. X-ray crystallography, binding assays, footprinting, small-angle X-ray scattering (SAXS) Nucleic acids research High 25753663
2014 Decreased LARP7 and 7SK levels redistribute P-TEFb to the transcriptionally active super elongation complex, resulting in increased transcription of EMT transcription factors (Slug, FOXC2, ZEB2, Twist1), promoting breast cancer EMT, invasion, and metastasis; LARP7 suppresses P-TEFb activity to inhibit these processes. siRNA knockdown, overexpression, invasion/migration assays, gene expression analysis eLife High 25053741
2018 Crystal structure (2.2 Å) of human Larp7 xRRM (C-terminal atypical RRM) bound to 7SK stem-loop 4 reveals a unique binding interface; the xRRM is preordered to bind a flexible loop 4; mutagenesis and ITC confirm specific contacts; combined with the La module structure, a model for full Larp7 binding to 7SK 3' end and mechanism for 7SK RNP assembly is proposed. X-ray crystallography (2.2 Å), NMR 13C spin relaxation, isothermal titration calorimetry, mutagenesis Proceedings of the National Academy of Sciences of the United States of America High 29946027
2018 Fission yeast LARP7 ortholog Lar7 binds telomerase RNA via conserved RNA-recognition motifs to protect it from exosomal degradation, stabilizes the association of telomerase RNA with the LSm2-8 complex and telomerase reverse transcriptase, and remains a component of the mature telomerase complex required for telomerase localization to the telomere. Genetic deletion, RNA-protein interaction assays, telomere localization assays (ortholog study in S. pombe) Nature communications High 29422501
2018 Fission yeast LARP7-like protein Pof8 uses its C-terminal xRRM domain to promote assembly of RNA Pol II-encoded telomerase RNA with TERT, and contributes to repression of noncoding RNA transcription at telomeres. Genetic analysis, domain deletion/mutation studies, RNA-protein interaction assays (ortholog study in S. pombe) Nature communications High 29422503
2016 LARP7 silencing in human cancer cells reduces telomerase enzymatic activity and causes progressive telomere shortening; Alazami syndrome patients with LARP7 loss-of-function show very short lymphocyte telomeres. siRNA knockdown, telomerase activity assay (TRAP), telomere length measurement, patient cohort analysis BMC genomics Medium 27766953
2020 LARP7 physically connects the spliceosomal U6 snRNA with a distinct subset of box C/D snoRNAs guiding U6 2'-O-methylation; depletion of LARP7 severely compromises these U6 modifications and causes alternative splicing perturbations; Alazami syndrome patients carrying a LARP7 mutation show defective U6 2'-O-methylation. Co-immunoprecipitation, RNA modification analysis, transcriptome-wide splicing analysis, patient samples Molecular cell High 32017898
2020 LARP7 promotes loading of U6 snRNA onto box C/D snoRNP, facilitating U6 2'-O-methylation; ablation of LARP7 in mouse male germline causes defective U6 2'-O-methylation, massive alterations in pre-mRNA splicing, and spermatogenic failure, rescued by wild-type LARP7 but not a U6-loading-deficient LARP7 mutant. Conditional knockout mouse, rescue with wild-type vs. mutant LARP7, U6 modification analysis, splicing transcriptome analysis Molecular cell High 32017896
2021 Cardiac-specific LARP7 knockout causes defective mitochondrial biogenesis, impaired oxidative phosphorylation, elevated oxidative stress, and heart failure; mechanistically, LARP7 loss reduces SIRT1 stability and deacetylase activity, impairing SIRT1-mediated transcription of oxidative phosphorylation and energy metabolism genes. Reactive oxygen species activate ATM kinase, which promotes LARP7 ubiquitination and degradation. Cardiac-specific and global KO mice, AAV9-mediated LARP7 overexpression, ATM inhibitor treatment, mitochondrial function assays, SIRT1 activity assays Circulation High 33663221
2021 DNA damage-mediated ATM activation triggers extracellular shuttling and downregulation of LARP7, which dampens SIRT1 deacetylase activity, enhances p53 and NF-κB (p65) transcriptional activity by augmenting their acetylation, accelerating cellular senescence; LARP7 deletion leads to senescent cell accumulation and premature aging in rodent model. LARP7 deletion in rodent model, SIRT1 deacetylase activity assays, acetylation analysis of p53/NF-κB, cellular senescence assays Cell reports High 34818543
2019 Legionella AnkH effector interacts with host nuclear LARP7 in the host cell nucleus, partially impeding interactions of 7SK snRNP components with LARP7 and interfering with Pol II transcriptional elongation; a substitution in the third ankyrin repeat of AnkH diminishes LARP7-AnkH interaction and phenocopies ankH null mutant defect in intracellular growth. Co-immunoprecipitation, crystal structure of AnkH, site-directed mutagenesis, bacterial infection assays mBio Medium 31455655
2015 In zebrafish, Larp7 knockdown de-represses Cdk9 activity, increases phosphorylation of Ser2 on the C-terminal domain of RNA Pol II, and increases cardiomyocyte proliferation; Larp7 knockdown rescues the structural and functional cardiac phenotype caused by Cdk9 knockdown, placing Larp7 upstream of Cdk9/P-TEFb-mediated Pol II Ser2 phosphorylation in cardiomyocyte proliferation. Morpholino knockdown in zebrafish, epistasis analysis, Pol II CTD phosphorylation assay, cardiomyocyte proliferation and cardiac function readouts Journal of cell science Medium 26542022
2022 MCTS1 protein interacts with LARP7 (confirmed by reciprocal Co-IP, predominantly in cytoplasm), increases LARP7 protein half-life, and reduces LARP7 poly-ubiquitination, indicating MCTS1 stabilizes LARP7 by protecting it from proteasomal degradation. Co-immunoprecipitation, cycloheximide chase assay, ubiquitination Co-IP Clinical and experimental pharmacology & physiology Medium 35274760
2024 LARP7 interacts with SIRT6 to maintain SIRT6 expression; combined cadmium and high-fat diet exposure reduces LARP7 levels via YTHDF2-mediated m6A-dependent degradation of Larp7 mRNA, disrupting LARP7-SIRT6 interaction and decreasing SIRT6 expression, leading to hippocampal neuronal senescence. RNA immunoprecipitation, RNA stability assays, Co-IP, Larp7 overexpression rescue, YTHDF2 siRNA Journal of hazardous materials Medium 39002485
2024 LARP7 and MePCE are involved in the early stage of human telomerase RNA (hTR) biogenesis; they bind 3'-extended precursor forms and their binding is destabilized upon mature hTR production; LARP7/MePCE depletion inhibits conversion of the 3'-extended short form to mature hTR and causes cytoplasmic accumulation of hTR, resulting in telomere shortening. Biochemical fractionation, RNA binding assays, depletion experiments, telomere length assays Nature communications Medium 39009594
2025 HIV-1 infection triggers liquid-liquid phase separation of LARP7; Tat is incorporated into HIV-1-induced LARP7 condensates; conserved lysine residues in the intrinsically disordered region of LARP7 are essential for both its phase separation and inhibition of Tat-mediated transcription, sequestering P-TEFb and Tat within condensates to restrain HIV-1 transcription. Live cell imaging of LARP7 condensates, mutagenesis of IDR lysine residues, Tat-mediated transcription assays EMBO reports Medium 40113991
2025 LARP7's C-terminal domain interacts with the N-terminal domain of SIRT1 to enhance SIRT1 deacetylase activity, which facilitates NLRP3 deacetylation at K21/K22/K24, inhibiting inflammasome assembly and neuronal pyroptosis after ischemic stroke; domain deletion analysis and co-immunoprecipitation define the interaction interface. Co-immunoprecipitation, domain deletion analysis, proximity ligation assay, acetyl-proteomics, SIRT1 deacetylase activity assay, neuron-specific LARP7 KO mice Journal of neuroinflammation Medium 41351020
2025 In Drosophila, loss of Larp7 (ortholog) impairs locomotion and reduces axonal growth at neuromuscular junctions; Larp7 functions autonomously in motoneurons to promote axogenesis; reducing P-TEFb abundance partially rescues locomotion and axonal growth defects, placing Larp7 upstream of P-TEFb in transcriptional regulation of long, GC-rich promoter genes in motoneurons. Genetic deletion in Drosophila, locomotion assays, NMJ morphology analysis, genetic epistasis with P-TEFb reduction, transcriptomic analysis of mutant motoneurons bioRxivpreprint Medium
2025 LARP7 promotes replication fork slowing and RAD51-mediated replication fork reversal in response to agents that cause both replication and transcription stress (e.g., camptothecin, BET inhibitors), and supports homologous recombination at direct DSBs; this function is not required for HR in response to hydroxyurea (replication stress without transcription stress), indicating the mechanism is linked to LARP7's canonical 7SK-snRNP/Pol II regulatory function. LARP7 knockdown, DNA fiber assay (fork slowing), RAD51 recruitment assays, HR assays, epistasis with Pol II inhibition bioRxivpreprint Low
2024 LARP7 interacts with STING in cardiomyocytes (particularly under high glucose conditions); high glucose causes LARP7 to translocate from the nucleus to the cytoplasm where it interacts with accumulated STING to inhibit STING degradation via the autophagy-lysosomal pathway, contributing to cardiac dysfunction. Co-immunoprecipitation, immunofluorescence (subcellular localization), adenovirus-mediated knockdown/overexpression, STING inhibitor treatment Frontiers in bioscience Low 39082350
2024 LARP7 is required for meiotic sex chromosome inactivation (MSCI) in mice; in germline-specific Larp7-deficient spermatocytes, LARP7 normally localizes to the XY body; its absence leads to failure of sex chromosome transcriptional silencing, accumulation of H4K12ac and loss of H3K9me2 on XY chromatin, and arrest of spermatogenesis. Germline-specific Larp7 KO mice, immunofluorescence (XY body localization), histone modification analysis, transcriptional analysis of sex chromosome genes PloS one Medium 39637191
2023 Full-length Tetrahymena LARP7 protein p65 structure in telomerase was determined by cryo-EM combined with NMR; three previously unknown helices are identified (one in NTD that binds the La module, one extending RRM1, one preceding xRRM2) that stabilize p65-TER interactions; the extended La module interacts with four 3' terminal U nucleotides and additionally with the TER pseudoknot, stem 1, and 5' end. Cryo-EM focused classification, NMR spectroscopy (Tetrahymena ortholog p65) Journal of molecular biology High 37330293

Source papers

Stage 0 corpus · 48 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated. Nucleic acids research 207 18281698
2008 The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes. EMBO reports 149 18483487
2021 LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. Circulation 102 33663221
2021 LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity. Cell reports 90 34818543
2012 Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism. Human mutation 70 22865833
2014 LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. eLife 66 25053741
2013 RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP. Nucleic acids research 55 23471002
2015 Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7. Nucleic acids research 54 25753663
2012 LARP7 is a potential tumor suppressor gene in gastric cancer. Laboratory investigation; a journal of technical methods and pathology 52 22488152
2020 The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness. Molecular cell 51 32017898
2020 LARP7-Mediated U6 snRNA Modification Ensures Splicing Fidelity and Spermatogenesis in Mice. Molecular cell 50 32017896
2018 Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7. Proceedings of the National Academy of Sciences of the United States of America 50 29946027
2019 Interaction of the Ankyrin H Core Effector of Legionella with the Host LARP7 Component of the 7SK snRNP Complex. mBio 36 31455655
2018 LARP7 family proteins have conserved function in telomerase assembly. Nature communications 36 29422501
2018 LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast. Nature communications 33 29422503
2016 Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency. BMC genomics 31 27766953
2015 Broadening the phenotypic spectrum of pathogenic LARP7 variants: two cases with intellectual disability, variable growth retardation and distinct facial features. Journal of human genetics 25 26607181
2015 Compound heterozygous variants in the LARP7 gene as a cause of Alazami syndrome in a Caucasian female with significant failure to thrive, short stature, and developmental disability. American journal of medical genetics. Part A 23 26374271
2015 CDK9 and its repressor LARP7 modulate cardiomyocyte proliferation and response to injury in the zebrafish heart. Journal of cell science 19 26542022
2020 Stabilize and connect: the role of LARP7 in nuclear non-coding RNA metabolism. RNA biology 17 32401147
2018 Novel compound heterozygous variants in the LARP7 gene in a patient with Alazami syndrome. Human genome variation 17 29619239
2018 LARP7 in papillary thyroid carcinoma induces NIS expression through suppression of the SHH signaling pathway. Molecular medicine reports 15 29620212
2016 Unraveling the conformational determinants of LARP7 and 7SK small nuclear RNA by theoretical approaches. Molecular bioSystems 14 27301448
2020 Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins. RNA biology 10 33131423
2025 Glucose-regulating hydrogel for immune modulation and angiogenesis through metabolic reprogramming and LARP7-SIRT1 pathway in infected diabetic wounds. Biomaterials 9 39951832
2023 Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR. Journal of molecular biology 8 37330293
2022 MCTS1 promotes laryngeal squamous cell carcinoma cell growth via enhancing LARP7 stability. Clinical and experimental pharmacology & physiology 7 35274760
2022 Involvement of LARP7 in Activation of SIRT1 to Inhibit NF-κB Signaling Protects Microglia from Acrylamide-Induced Neuroinflammation. Neurotoxicity research 6 36550222
2020 Novel Mutation in LARP7 in Two Iranian Consanguineous Families with Syndromic Intellectual Disability and Facial Dysmorphism. Archives of Iranian medicine 6 33356342
2024 Adolescent co-exposure to environmental cadmium and high-fat diet induces cognitive decline via Larp7 m6A-mediated SIRT6 inhibition. Journal of hazardous materials 5 39002485
2020 Compound Phenotype Due to Recessive Variants in LARP7 and OTOG Genes Disclosed by an Integrated Approach of SNP-Array and Whole Exome Sequencing. Genes 5 32244554
2024 LARP3, LARP7, and MePCE are involved in the early stage of human telomerase RNA biogenesis. Nature communications 4 39009594
2024 Exome Sequencing Detects Uniparental Disomy of Chromosome 4 Revealing a LARP7 Pathogenic Variant Responsible for Alazami Syndrome: A Case Report. American journal of medical genetics. Part A 4 39417555
2020 The Interlocking Lives of LARP7: Fine-Tuning Transcription, RNA Modification, and Splicing through Multiple Non-coding RNAs. Molecular cell 4 32243831
2023 LARP7 alleviates psoriasis symptoms in mice by regulating the SIRT1/NF-κB signaling pathway. Allergologia et immunopathologia 3 36617833
2025 Transcriptome-proteome integration analysis identifies elevated expression of LARP7 promoting the tumorigenesis and development of gastrointestinal stromal tumors. Translational oncology 2 39933393
2025 Liquid-liquid phase separation of LARP7 restrains HIV-1 replication. EMBO reports 2 40113991
2025 Alazami syndrome with a single LARP7 variant and concurrent osteo-oto-hepato-enteric syndrome: A case of complex genetic interplay. Radiology case reports 2 40129845
2024 LARP7 Contributes to Glucose-Induced Cardiac Dysfunction, Apoptosis and Fibrosis by Inhibiting the Degradation of STING. Frontiers in bioscience (Landmark edition) 2 39082350
2025 Functional Characterization of Variants in LARP7: Report of Three New Individuals With Alazami Syndrome and a Literature Review. Human mutation 1 40548259
2024 LARP7 is required for sex chromosome silencing during meiosis in mice. PloS one 1 39637191
2023 [Clinical and genetic analysis of a child with Alazami syndrome due to compound heterozygous variants of LARP7 gene]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 1 37368391
2023 LARP7 upregulates SIRT1 deacetylase activity and inhibits Th1/Th17 cytokine response in psoriatic mice. Allergologia et immunopathologia 1 37937491
2026 LARP7 promotes postnatal cardiac regeneration by facilitating G2/M phase transition. Journal of molecular and cellular cardiology 0 41667032
2026 Expanding the phenotypic and immunological landscape of Alazami syndrome: Evidence from seven new patients with LARP7 gene variants. European journal of pediatrics 0 41811398
2026 LARP7 Enhances the Potential of Dental Pulp Stem Cells to Promote Peripheral Nerve Repair. Stem cells (Dayton, Ohio) 0 41812059
2025 Liraglutide Attenuates Endothelial Dysfunction by Inhibiting Hyperglycemia-Induced Endothelial Cell Senescence Through the LARP7/SIRT1 Pathway. Archivum immunologiae et therapiae experimentalis 0 41343751
2025 LARP7 protects against ischemic brain injury by modulating NLRP3 deacetylation to suppress neuronal pyroptosis. Journal of neuroinflammation 0 41351020