Affinage

LAMA3

Laminin subunit alpha-3 · UniProt Q16787

Length
3333 aa
Mass
366.6 kDa
Annotated
2026-06-10
56 papers in source corpus 17 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LAMA3 encodes the α3 chain of laminin-332 (epiligrin/laminin 5), a basement membrane glycoprotein that functions as a direct extracellular adhesion ligand coordinating epithelial attachment, differentiation, and survival (PMID:2032285, PMID:10366601). As immunopurified epiligrin it engages integrin α3β1 to drive focal adhesion and suppress keratinocyte migration—marking this receptor–ligand pair as anti-migratory—while colocalizing with integrin α6β4 in hemidesmosome-like stable anchoring contacts (PMID:2032285, PMID:1569325). Anchorage of α6β4 to laminin 5 governs a distinct signaling event: dissociation of α6β4 from the ligand triggers tyrosine phosphorylation of a membrane-associated 80-kDa substrate by a kinase active in suspended keratinocytes, a pathway not affected by α3β1 blockade (PMID:8647901). Adhesion through α3β1 also restrains epidermal differentiation by reducing involucrin induction (PMID:7769020). The gene produces α3EpA and α3EpB transcripts whose C-terminal G domain is structurally related to other laminin α chains, and it maps to chromosome 18q11.2 (PMID:8077230). Genetic ablation in mice establishes its physiological requirements: loss eliminates stable α6β4 adhesion and hemidesmosomes, impairs epithelial survival (rescuable by exogenous laminin 5, collagen, or anti-α6β4 antibody), and disrupts ameloblast differentiation (PMID:10366601); conditional adult deletion causes subepidermal blistering, skin inflammation, and fibrosis (PMID:27729280); and disruption arrests glomerular maturation, with LAMA3 required for glomerular endothelial cell differentiation and mesangial cell migration (PMID:16850021). Human haploinsufficiency causes localized enamel pitting, defining a dosage-sensitive role in amelogenesis (PMID:27827380). LAMA3 transcription is regulated cell-type-specifically through an AP-1 epithelial enhancer and UV-induced USF-1 binding at a non-canonical promoter E-box (PMID:11937633), and in cancer contexts by LINC00628-recruited DNMT-mediated CpG methylation (PMID:31557618), METTL3-dependent m6A stabilization (PMID:38305336), miR-212-5p targeting (PMID:40004224), and the transcription factors SPI1 and HEYL (PMID:41217226, PMID:40833662); through these routes LAMA3 modulates Hippo-YAP signaling to influence oxaliplatin resistance (PMID:39798821) and EMT to influence radiosensitivity (PMID:40833662).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1991 High

    Established that the LAMA3-containing complex epiligrin is a bona fide extracellular adhesion ligand, identifying integrin α3β1 as its focal-adhesion receptor and α6β4 as a co-localizing partner in stable anchoring contacts.

    Evidence Immunopurified epiligrin in cell adhesion assays with reciprocal antibody blocking and immunolocalization across cell types

    PMID:2032285

    Open questions at the time
    • Did not resolve which laminin domain mediates α3β1 versus α6β4 engagement
    • Functional consequence of dual-receptor superstructure not yet defined
  2. 1992 Medium

    Defined the cellular consequence of α3β1–epiligrin binding by showing it immobilizes keratinocytes, framing this pair as anti-migratory rather than promotile.

    Evidence Keratinocyte migration assays with monospecific integrin-blocking antibodies on multiple matrices

    PMID:1569325

    Open questions at the time
    • Single-lab finding
    • Downstream signaling controlling immobility not identified
  3. 1993 Medium

    Extended epiligrin–α3β1 adhesion beyond epithelium to T lymphocytes and demonstrated it is affinity-regulated, indicating activation-state control of the interaction.

    Evidence Adhesion assays with reciprocal and activating anti-β1 antibodies, flow cytometry, patient biopsy immunohistochemistry

    PMID:8501119

    Open questions at the time
    • Physiological role of lymphocyte adhesion to epiligrin unclear
    • Mechanism of affinity regulation not resolved
  4. 1994 High

    Resolved the molecular identity of LAMA3, defining its two transcripts, conserved G-domain architecture, and chromosomal location.

    Evidence cDNA cloning and sequencing of independent clones, FISH mapping, Northern hybridization

    PMID:8077230

    Open questions at the time
    • Functional distinctness of α3EpA vs α3EpB not tested
    • G-domain ligand specificities not assigned
  5. 1995 High

    Separated α6β4 signaling from α3β1 by showing that α6β4 anchorage to laminin 5 specifically controls phosphorylation of an 80-kDa membrane substrate, revealing distinct receptor-specific signaling outputs from a single ligand.

    Evidence Low-temperature adhesion, immunoprecipitation/phosphorylation and in vitro kinase assays, antibody blocking, subcellular fractionation

    PMID:8647901

    Open questions at the time
    • Molecular identity of the 80-kDa substrate and its kinase not determined
    • Downstream functional consequence of p80 phosphorylation unknown
  6. 1995 Medium

    Linked α3β1–epiligrin adhesion to control of epidermal differentiation by showing it suppresses antibody-induced involucrin expression.

    Evidence Culture on purified epiligrin versus other ECM with antibody-triggered differentiation readout

    PMID:7769020

    Open questions at the time
    • Signaling pathway connecting adhesion to involucrin repression not mapped
    • Single defined differentiation marker tested
  7. 1999 High

    Established the in vivo requirements for LAMA3 in epithelial biology, showing it is needed for hemidesmosome-mediated α6β4 adhesion, epithelial survival, and ameloblast differentiation, and that survival signaling can be supplied via β1/β4 integrins.

    Evidence Constitutive knockout mouse with tissue adhesion assays and rescue using exogenous matrix proteins and anti-α6β4 antibody, histology, EM

    PMID:10366601

    Open questions at the time
    • Identity of the alternative α3β1 ligand emerging in knockout BM unknown
    • Mechanism linking adhesion to survival not fully defined
  8. 2002 High

    Defined cell-type-specific transcriptional control of LAMA3 through an AP-1 epithelial enhancer and UV-stress-induced USF-1 binding at a non-canonical promoter E-box that relieves fibroblast repression.

    Evidence ChIP demonstrating in vivo USF binding, reporter assays, UV induction, promoter mutagenesis

    PMID:11937633

    Open questions at the time
    • Composition of the fibroblast repressor complex not identified
    • Physiological role of UV-induced upregulation not established
  9. 2006 High

    Revealed a developmental role beyond skin, showing LAMA3 is required for glomerular endothelial cell differentiation and mesangial cell migration during kidney maturation.

    Evidence Knockout mouse with developmental arrest phenotype, protein localization, in situ hybridization, primary GEnC culture

    PMID:16850021

    Open questions at the time
    • Receptor mediating LAMA3 effects on GEnCs not identified
    • Mechanism of mesangial cell recruitment unresolved
  10. 2016 High

    Demonstrated that α3-laminins are required for adult skin homeostasis, not only development, with their loss driving blistering, inflammation, and collagen-rich fibrosis.

    Evidence Inducible conditional knockout in adult mouse keratinocytes with histology, immunofluorescence, collagen staining

    PMID:27729280

    Open questions at the time
    • Mechanism linking laminin loss to fibrotic collagen accumulation not defined
    • Contribution of inflammation versus direct adhesion loss unresolved
  11. 2016 Medium

    Established LAMA3 dosage sensitivity in humans, showing heterozygous null mutations cause enamel pitting in the absence of blistering.

    Evidence Clinical phenotyping, identification of nonsense and splice-site mutations, family segregation

    PMID:27827380

    Open questions at the time
    • Tissue-specific threshold explaining enamel-only phenotype not defined
    • Molecular mechanism of amelogenesis dependence unresolved
  12. 2024 Medium

    Identified post-transcriptional control of LAMA3 by METTL3-mediated m6A modification that stabilizes its transcripts and promotes malignant phenotype in oral squamous cell carcinoma.

    Evidence MeRIP, mRNA stability assay, siRNA knockdown with rescue, functional assays

    PMID:38305336

    Open questions at the time
    • m6A reader mediating stabilization not identified
    • Single cancer context
  13. 2025 Medium

    Placed LAMA3 upstream of Hippo-YAP signaling in controlling chemoresistance, showing its knockdown sensitizes colon cancer to oxaliplatin in a YAP-dependent manner.

    Evidence siRNA knockdown with YAP overexpression epistasis rescue, western blot, xenograft

    PMID:39798821

    Open questions at the time
    • Molecular link between extracellular LAMA3 and intracellular YAP not defined
    • Single-lab finding
  14. 2025 Medium

    Identified additional transcriptional and microRNA regulators (SPI1, HEYL, miR-212-5p) controlling LAMA3 expression and linked LAMA3 to EMT-driven radioresistance, PI3K-AKT/NF-κB signaling, and tumor angiogenesis/ferroptosis.

    Evidence ChIP, dual-luciferase reporter assays, knockdown with rescue, pathway western blots, functional and xenograft assays

    PMID:40004224 PMID:40833662 PMID:41217226

    Open questions at the time
    • Mechanism connecting secreted laminin to intracellular signaling pathways not established
    • Findings each from single labs in distinct cancer types
  15. 2025 Medium

    Refined the role of hemidesmosomal laminin in differentiation, showing embryonic mosaic Lama3 loss increases keratinocyte delamination without embryonic epidermal-dermal separation.

    Evidence In utero lentiviral mosaic knockout with live imaging and division-orientation analysis (preprint)

    Open questions at the time
    • Preprint not yet peer-reviewed
    • Signaling controlling delamination downstream of laminin not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the membrane-proximal signaling outputs of laminin-332 (the 80-kDa substrate and its kinase) connect mechanistically to the intracellular pathways modulating cancer phenotypes (Hippo-YAP, PI3K-AKT, NF-κB, EMT) remains unresolved.
  • Identity of the 80-kDa substrate/kinase still unknown
  • No mechanistic bridge between extracellular adhesion and intracellular oncogenic signaling established
  • Receptor usage in non-epithelial and tumor contexts not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0098631 cell adhesion mediator activity 3 GO:0048018 receptor ligand activity 2
Localization
GO:0005576 extracellular region 3 GO:0030312 external encapsulating structure 3
Pathway
R-HSA-1474244 Extracellular matrix organization 3 R-HSA-1266738 Developmental Biology 2 R-HSA-1500931 Cell-Cell communication 2
Partners
ITGA3ITGA6ITGB1ITGB4
Complex memberships
hemidesmosomelaminin-332 (laminin 5/epiligrin)

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1991 Epiligrin (LAMA3-containing complex) is a direct adhesion ligand for integrin α3β1 in epithelial basement membranes; immunopurified epiligrin induced cell adhesion and localization of integrin α3β1 in focal adhesions, and adhesion was blocked by anti-α3β1 antibody. Epiligrin also colocalized with integrin α6β4 in hemidesmosome-like stable anchoring contacts (SACs), forming a complex adhesion superstructure. Immunopurification, cell adhesion assay, monoclonal antibody blocking, immunolocalization/co-localization Cell High 2032285
1992 Blocking integrin α3β1 (the epiligrin receptor) uniquely enhanced keratinocyte migration on fibronectin and collagen matrices, indicating that α3β1–epiligrin interaction is associated with immobility rather than motility, defining an anti-migratory function for this receptor–ligand pair. Keratinocyte migration assay with monospecific blocking antibodies against integrin subunits The Journal of investigative dermatology Medium 1569325
1993 Epiligrin (LAMA3-containing ECM) is an adhesion ligand for α3β1-positive T lymphocytes; adhesion was inhibitable by anti-α3 and anti-β1 antibodies and by an anti-epiligrin monoclonal antibody (P3H9-2), and could be upregulated by activating anti-β1 antibodies, demonstrating affinity-regulated binding. Cell adhesion assay with blocking monoclonal antibodies, flow cytometry, immunohistochemistry of patient skin biopsies The Journal of cell biology Medium 8501119
1994 The LamA3 gene encodes two distinct transcripts (α3EpA and α3EpB) with structural homology to laminin α1 and α2 chains from domain IIIa through the C-terminal G domain; the G domain contains five subdomains individually related to G subdomains of other laminin α chains, with sequence divergence suggesting functional distinctiveness from other laminins. The LAMA3 gene maps to chromosome 18q11.2. cDNA cloning and sequencing, fluorescence in situ hybridization (FISH), Northern hybridization The Journal of biological chemistry High 8077230
1995 Anchorage of integrin α6β4 to laminin 5 (epiligrin) specifically regulates tyrosine phosphorylation of a membrane-associated 80-kD protein (p80); dissociation of α6β4 from laminin 5 induced p80 phosphorylation, while blocking α3β1 function did not affect p80 phosphorylation, identifying a distinct α6β4-specific signaling event downstream of laminin 5 binding. A kinase activity for p80 phosphorylation was identified in suspended HFKs but not attached cells. Low-temperature adhesion system, immunoprecipitation/phosphorylation assays, blocking antibodies against integrin subunits, cytochalasin D treatment, in vitro kinase assay, subcellular fractionation The Journal of cell biology High 8647901
1995 Keratinocyte adhesion to purified epiligrin (but not other matrix components) specifically reduces involucrin expression induced by anti-α3β1 antibody (P1B5), demonstrating that epiligrin–α3β1 interaction inhibits α3β1-mediated epidermal differentiation. Culture on purified epiligrin, antibody-triggered differentiation assay, involucrin expression measurement Journal of cell science Medium 7769020
1999 Targeted disruption of the LAMA3 gene in mice (removing all α3-laminin isoforms from epithelial BMs) caused: (1) failure of integrin α6β4 to form stable adhesion to mutant BM, consistent with hemidesmosome loss; (2) epithelial cell survival defect rescuable by exogenous laminin 5, collagen, or anti-integrin α6β4 antibody, indicating signaling through β1 or β4 integrins is sufficient for survival; (3) ameloblast differentiation defects; and (4) emergence of an alternative α3β1 ligand in the epidermal BM in the absence of laminin 5. Gene targeting/knockout, novel tissue adhesion assay, survival rescue experiments with exogenous matrix proteins and antibodies, histology, electron microscopy The Journal of cell biology High 10366601
2002 The lama3 gene promoter contains a non-canonical E-box bound by USF-1 following UV stress; USF-1 binding relieves repression of lama3 in fibroblasts (where a repressor complex normally silences the gene), while expression remains constitutively high in keratinocytes. An epithelial enhancer with AP-1 binding sites controls cell-type-specific lama3 expression. Chromatin immunoprecipitation confirmed UV-induced USF binding to the lama3 promoter in vivo. Chromatin immunoprecipitation (ChIP), reporter assays, UV stress induction, promoter deletion/mutagenesis analysis Nucleic acids research High 11937633
2006 Targeted disruption of lama3 in mice arrested glomerular maturation at the early capillary loop stage: endothelial cells failed to attenuate, develop fenestrae, or form lumens, and mesangial cells were absent. LAMA3 protein was localized to the basement membrane adjacent to glomerular endothelial cells (GEnCs), and lama3 mRNA/protein were identified in isolated glomeruli and cultured GEnCs but not in mesangial cells, establishing a required role for LAMA3 in GEnC differentiation and mesangial cell migration. Gene knockout mouse model, immunohistochemistry/protein localization, in situ hybridization, cell fractionation of isolated glomeruli, cultured GEnCs Kidney international High 16850021
2016 Conditional disruption of the Lama3 gene in basal keratinocytes of adult mice caused gradual loss of α3 chain-containing laminins at the dermal-epidermal junction, subepidermal blistering, nail loss, skin inflammation, and fibrosis with extensive accumulation of interstitial and microfibrillar collagens and scattered collagen VII deposition, demonstrating that α3-laminin isoforms are required for adult skin homeostasis. Conditional/inducible gene knockout in adult mice, histology, immunofluorescence, collagen staining The Journal of investigative dermatology High 27729280
2016 Heterozygous functional null mutations in LAMA3 cause localized enamel pitting (haploinsufficiency) in the absence of skin blistering, demonstrating that a half-dose of laminin α3 chain is insufficient for normal enamel formation, establishing a dosage-sensitive role for LAMA3 in amelogenesis. Clinical phenotyping of heterozygous carriers, molecular analysis (identification of nonsense c.2377C>T and splice-site c.4684+1G>A mutations), family segregation analysis European journal of human genetics Medium 27827380
2019 LINC00628 recruits DNMT1, DNMT3A, and DNMT3B to the LAMA3 promoter, promoting CpG methylation and silencing LAMA3 expression; LINC00628 silencing reduced LAMA3 promoter methylation and restored its expression, with functional consequences including decreased lung adenocarcinoma cell proliferation, migration, invasion, and vincristine resistance. ChIP assay (DNMT recruitment), pyrosequencing (methylation), siRNA knockdown, 5-azacytidine treatment, cell functional assays, in vivo xenograft Molecular therapy. Nucleic acids Medium 31557618
2024 METTL3 upregulates LAMA3 expression via N6-methyladenosine (m6A) modification-dependent stabilization of LAMA3 transcripts in oral squamous cell carcinoma; methylated RNA immunoprecipitation and mRNA stability assays confirmed this regulatory mechanism, and low METTL3 partially reversed the enhanced malignant phenotype induced by LAMA3 overexpression. Methylated RNA immunoprecipitation (MeRIP), mRNA stability assay, siRNA knockdown, cell functional assays, RT-qPCR Critical reviews in immunology Medium 38305336
2025 LAMA3 knockdown sensitizes colon cancer cells to oxaliplatin by modulating the Hippo-YAP pathway; overexpression of YAP counteracted the enhanced oxaliplatin sensitivity caused by LAMA3 knockdown, placing LAMA3 upstream of YAP in regulating drug resistance. This was confirmed in vitro and in CC xenograft models. siRNA knockdown, YAP overexpression rescue, western blot (pathway analysis), KEGG enrichment, in vivo xenograft Biochimica et biophysica acta. Molecular basis of disease Medium 39798821
2025 SPI1 (PU.1) transcription factor binds to the LAMA3 promoter and directly activates its transcription in esophageal squamous cell carcinoma, as demonstrated by ChIP and dual luciferase reporter assays; LAMA3 silencing suppressed tumor growth, angiogenesis (tube formation), and induced ferroptosis and oxidative stress in ESCC cells. ChIP assay, dual luciferase reporter assay, siRNA knockdown, CCK-8/EdU/colony formation, tube formation assay, in vivo xenograft, ferroptosis/oxidative stress markers General physiology and biophysics Medium 41217226
2025 HEYL binds to the LAMA3 promoter and activates its transcription; in vitro and in vivo rescue experiments demonstrated that HEYL-mediated transcriptional activation of LAMA3 reduces esophageal cancer radiosensitivity by inducing the epithelial-to-mesenchymal transition (EMT) pathway. Chromatin binding assay (HEYL-LAMA3 promoter interaction), RT-qPCR, western blot, transwell/wound healing/CCK-8/EdU assays, in vivo radioresistant model, immunofluorescence Esophagus Medium 40833662
2025 miR-212-5p directly targets LAMA3 (and LAMC2), as demonstrated by dual-luciferase reporter assay; LAMA3 positively regulates the PI3K-AKT pathway and negatively regulates the NF-κB pathway, thereby controlling PM2.5-induced apoptosis rates. Dual-luciferase reporter assay (direct miRNA target validation), pathway western blot, apoptosis flow cytometry International journal of molecular sciences Medium 40004224
2025 Mosaic epidermal-specific loss of laminin-α3β3γ2 (Lama3) in embryonic mice, generated by in utero lentiviral delivery, increases keratinocyte delamination (basal-to-suprabasal transition) without causing epidermal-dermal separation embryonically, demonstrating a causal role for hemidesmosomal laminin in regulating epidermal differentiation through the delamination mechanism. In utero lentiviral-mediated mosaic knockout, live imaging/cell tracking, immunofluorescence, cell division orientation analysis bioRxivpreprint Medium

Source papers

Stage 0 corpus · 56 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1991 Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes. Cell 715 2032285
1999 Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. The Journal of cell biology 262 10366601
1994 Cloning of the LamA3 gene encoding the alpha 3 chain of the adhesive ligand epiligrin. Expression in wound repair. The Journal of biological chemistry 249 8077230
1993 Epiligrin, a component of epithelial basement membranes, is an adhesive ligand for alpha 3 beta 1 positive T lymphocytes. The Journal of cell biology 161 8501119
1995 A homozygous nonsense mutation in the alpha 3 chain gene of laminin 5 (LAMA3) in lethal (Herlitz) junctional epidermolysis bullosa. Human molecular genetics 143 7633458
1996 Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein. The Journal of cell biology 113 8647901
1995 Cloning of the laminin alpha 3 chain gene (LAMA3) and identification of a homozygous deletion in a patient with Herlitz junctional epidermolysis bullosa. Genomics 94 8586427
1992 Integrin receptors and RGD sequences in human keratinocyte migration: unique anti-migratory function of alpha 3 beta 1 epiligrin receptor. The Journal of investigative dermatology 93 1569325
2003 Anti-epiligrin cicatricial pemphigoid: clinical findings, immunopathogenesis, and significant associations. Medicine 79 12792304
1994 Junctional epidermolysis bullosis: defects in expression of epiligrin/nicein/kalinin and integrin beta 4 that inhibit hemidesmosome formation. The Journal of investigative dermatology 77 7963682
1995 Differential cytokine modulation of the genes LAMA3, LAMB3, and LAMC2, encoding the constitutive polypeptides, alpha 3, beta 3, and gamma 2, of human laminin 5 in epidermal keratinocytes. FEBS letters 58 7635220
2004 Comparative analysis of methods for detection of anti-laminin 5 autoantibodies in patients with anti-epiligrin cicatricial pemphigoid. Journal of the American Academy of Dermatology 43 15583578
1997 Noncomplement fixing, IgG4 autoantibodies predominate in patients with anti-epiligrin cicatricial pemphigoid. The Journal of investigative dermatology 42 9326390
1995 A homozygous nonsense mutation in the alpha 3 chain gene of laminin 5 (LAMA3) in Herlitz junctional epidermolysis bullosa: prenatal exclusion in a fetus at risk. Genomics 42 8530087
2019 Long Non-coding RNA LINC00628 Interacts Epigenetically with the LAMA3 Promoter and Contributes to Lung Adenocarcinoma. Molecular therapy. Nucleic acids 38 31557618
2007 A widening perspective regarding the relationship between anti-epiligrin cicatricial pemphigoid and cancer. Journal of dermatological science 38 17467241
1995 Modulation of epidermal differentiation by epiligrin and integrin alpha 3 beta 1. Journal of cell science 37 7769020
2008 Partial deletion of the LAMA3 gene is responsible for hereditary junctional epidermolysis bullosa in the American Saddlebred Horse. Animal genetics 30 19016681
2006 Abnormal development of glomerular endothelial and mesangial cells in mice with targeted disruption of the lama3 gene. Kidney international 29 16850021
1998 [Cicatricial pemphigoid with autoantibodies to laminin 5 (epiligrin) in a patient with metastatic endometrial carcinoma]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 27 9522190
1996 A recurrent homozygous nonsense mutation within the LAMA3 gene as a cause of Herlitz junctional epidermolysis bullosa in patients of Pakistani ancestry: evidence for a founder effect. The Journal of investigative dermatology 23 8618022
2021 LAMA3 DNA methylation and transcriptome changes associated with chemotherapy resistance in ovarian cancer. Journal of ovarian research 22 33992120
2017 Substrate-mediated gene transduction of LAMA3 for promoting biological sealing between titanium surface and gingival epithelium. Colloids and surfaces. B, Biointerfaces 22 29096376
2002 Binding of USF to a non-canonical E-box following stress results in a cell-specific derepression of the lama3 gene. Nucleic acids research 22 11937633
2016 Targeted Disruption of the Lama3 Gene in Adult Mice Is Sufficient to Induce Skin Inflammation and Fibrosis. The Journal of investigative dermatology 20 27729280
2016 Carriers with functional null mutations in LAMA3 have localized enamel abnormalities due to haploinsufficiency. European journal of human genetics : EJHG 20 27827380
2012 Meningoencephalitis associated with Carnobacterium maltaromaticum-like bacteria in stranded juvenile salmon sharks (Lamna ditropis). Veterinary pathology 20 22452824
2014 Association of variation in the LAMA3 gene, encoding the alpha-chain of laminin 5, with atopic dermatitis in a German case-control cohort. BMC dermatology 19 25363238
2023 Upregulated LAMA3 modulates proliferation, adhesion, migration and epithelial‑to‑mesenchymal transition of cholangiocarcinoma cells. Scientific reports 16 38114514
2023 LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3. Recent patents on anti-cancer drug discovery 15 35297352
2020 Adenovirus-Mediated LAMA3 Transduction Enhances Hemidesmosome Formation and Periodontal Reattachment during Wound Healing. Molecular therapy. Methods & clinical development 12 32671133
2022 Phenotypic variability in LAMA3-associated amelogenesis imperfecta. Oral diseases 11 36326426
1995 Epiligrin is decreased in papulonodular basal cell carcinoma tumor nest basement membranes and the extracellular matrix of transformed human epithelial cells. Experimental dermatology 11 7551559
2022 Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families. Frontiers of medicine 8 35314946
1998 Abnormal expression of epiligrin and alpha 6 beta 4 integrin in basal cell carcinoma. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 8 9598011
2021 Canine junctional epidermolysis bullosa due to a novel mutation in LAMA3 with severe upper respiratory involvement. Veterinary dermatology 7 34250689
2024 LAMA3 Promotes Tumorigenesis of Oral Squamous Cell Carcinoma by METTL3-Mediated N6-Methyladenosine Modification. Critical reviews in immunology 6 38305336
2025 Knockdown of LAMA3 enhances the sensitivity of colon cancer to oxaliplatin by regulating the Hippo-YAP pathway. Biochimica et biophysica acta. Molecular basis of disease 4 39798821
2025 miR-212-5p Regulates PM2.5-Induced Apoptosis by Targeting LAMC2 and LAMA3. International journal of molecular sciences 4 40004224
2014 The complete mitochondrial genome of the salmon shark, Lamna ditropis (Chondrichthyes, Lamnidae). Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis 4 24660916
1998 The amino acid sequences of two acylphosphatase isoforms from fish muscle (Lamna nasus). Biochimica et biophysica acta 4 9748622
2023 A missense mutation in Lama3 causes androgen alopecia. Scientific reports 3 38012251
2012 Detection of novel LAMA3 mutation in Herlitz junctional epidermolysis bullosa in a Jordanian family. The Australasian journal of dermatology 2 22963541
2010 A novel LAMA3 mutation in a newborn with junctional epidermolysis bullosa herlitz type. Neonatology 2 20881434
2022 [A pedigree study of laryngo-onycho-cutaneous syndrome with a novel mutation on LAMA3 gene]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery 1 35193344
2005 cDNA sequence of the horse (Equus caballus) LAMA3 gene and characterization of two intronic SNP markers. DNA sequence : the journal of DNA sequencing and mapping 1 16287627
2026 Atypical dentition of a Porbeagle Shark (Lamna nasus) highlights odontological considerations in the taxonomy and phylogenetics of sharks. Anatomical record (Hoboken, N.J. : 2007) 0 41748473
2026 Dissecting the immunosuppressive microenvironment of LAMA3 + malignant cells and SPP1 + macrophages in esophageal squamous cell carcinoma using single-cell and spatial transcriptomics. Journal of translational medicine 0 41845425
2026 Computational multi-omics integration suggests an association between LAMA3 expression, immune suppression, and metabolic programs in pancreatic ductal adenocarcinoma. Discover oncology 0 41854943
2025 LAMA3 overexpression enhances proliferation, migration and invasion in esophageal squamous cell carcinoma based on bioinformatics and experimental validation. Scientific reports 0 40628792
2025 Junctional Epidermolysis Bullosa Caused by a Hemiallelic Nonsense Mutation in LAMA3 Revealed by 18q11.2 Microdeletion. International journal of molecular sciences 0 40806473
2025 HEYL-mediated activation of LAMA3 influences radiotherapy response in esophageal cancer. Esophagus : official journal of the Japan Esophageal Society 0 40833662
2025 Transcription factor SPI1 exacerbates the malignant progression of esophageal squamous cell carcinoma byactivating LAMA3 expression. General physiology and biophysics 0 41217226
2025 Association of LAMA3 expression with perineural invasion and chemoresistance in pancreatic ductal adenocarcinoma. Discover oncology 0 41264049
2023 c.151dup variant in LAMA3 in Pakistani patients affected with Shabbir Syndrome but showing mild symptoms. Pakistan journal of medical sciences 0 37492301
2023 Sequence analysis of exons 30 and 31 of LAMA3 gene variants and its association with human papillomavirus infection predisposition: no evidence was found. European review for medical and pharmacological sciences 0 37522698

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