Affinage

ITGA3

Integrin alpha-3 · UniProt P26006

Length
1051 aa
Mass
116.6 kDa
Annotated
2026-06-10
51 papers in source corpus 25 papers cited in narrative 27 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ITGA3 is an integrin alpha subunit, derived by proteolytic cleavage into disulfide-linked heavy and light chains and bearing metal-binding motifs and a transmembrane segment characteristic of the integrin superfamily (PMID:1691184), that pairs with ITGB1 to form a cell-surface receptor coupling extracellular matrix engagement to migration, invasion, and progenitor cell behavior. As the α3β1 heterodimer it binds ECM ligands including autocrine collagen I and fibroblast-derived laminin-332, engagement of which drives FAK/PI3K/AKT/mTOR signaling to upregulate HIF1α/c-Myc-dependent glycolysis and to promote proliferation, invasion, and circulating-tumor-cell clustering (PMID:39690180, PMID:41881953). Across cancer types ITGA3 acts upstream of FAK/PI3K/AKT, FAK/Src, and ERK cascades and modulates EMT markers to control motility and anoikis resistance (PMID:29988949, PMID:29758195, PMID:30614803). It physically partners with VASP to regulate stemness and EMT (PMID:31987909) and cooperates with the MET receptor tyrosine kinase, promoting MET phosphorylation at Tyr1234/1235 and ERK and PI3K/AKT activation (PMID:40138447). ITGA3 expression is transcriptionally controlled by YY1 in trophoblasts (PMID:35970081) and by STAT3 during H. pylori-driven gastric carcinogenesis (PMID:42240927), post-transcriptionally repressed by numerous miRNAs (miR-223, the miR-199 family, miR-101, miR-124/124-3p, miR-183, miR-524-5p) (PMID:26509963, PMID:28612520, PMID:28102841, PMID:30614803, PMID:28777373), and stabilized at the mRNA level via the S100A16-MOV10 axis (PMID:39450567). Beyond cancer, ITGA3 supports tissue progenitor homeostasis: it sustains the hippocampal neural stem cell pool against ROS-driven depletion (PMID:38367510), drives ULK1-dependent autophagy to enable trophoblast invasion (PMID:39437445), and maintains alveolar AT2 progenitor self-renewal through FAK/YAP signaling, with NPNT engagement stabilizing YAP1 by restraining LATS1/MOB1 (PMID:41270956, PMID:40444575). Sialylated α3β1 also functions as a ligand for the macrophage inhibitory checkpoint Siglec-10 to suppress phagocytosis.

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1990 High

    Established the molecular identity of ITGA3 as an integrin alpha subunit, defining the structural basis for its receptor function.

    Evidence cDNA cloning, protein purification, and partial amino acid sequencing

    PMID:1691184

    Open questions at the time
    • Does not define the ligand specificity or signaling output of the protein
    • Heterodimer partner not functionally characterized in this study
  2. 2013 Medium

    Showed ITGA3 can act non-cell-autonomously, addressing whether the integrin contributes to tumor microenvironment remodeling beyond the cell expressing it.

    Evidence Exosome isolation, transwell assays, and ITGA3 inhibition in prostate cancer/prEC cells

    PMID:24371517

    Open questions at the time
    • Molecular mechanism by which exosomal ITGA3 acts on recipient cells unresolved
    • Whether intact α3β1 or cleaved fragments mediate the effect not addressed
  3. 2015 Medium

    Placed ITGA3 within post-transcriptional regulatory circuits controlling motility, beginning the mapping of upstream miRNA control.

    Evidence miR-223 restoration and ITGA3/ITGB1 siRNA knockdown with migration/invasion assays in prostate cancer

    PMID:26509963

    Open questions at the time
    • Direct binding inferred from expression rather than reporter assay
    • Downstream signaling not characterized here
  4. 2017 Medium

    Extended ITGA3 as a convergent miRNA target across head/neck, nasopharyngeal cancers and the developing cochlea, linking its dosage to proliferation and metastatic phenotypes.

    Evidence Ectopic miRNA expression, ITGA3 rescue, in vivo CAM metastasis model, and conditional Dicer knockout

    PMID:28102841 PMID:28612520 PMID:28777373

    Open questions at the time
    • Tissue-specific selectivity among the many ITGA3-targeting miRNAs unresolved
    • Whether ITGA3 protein level alone is the rate-limiting effector not isolated
  5. 2018 Medium

    Defined the downstream signaling consequences of ITGA3, placing it upstream of FAK/AKT/ERK and as a regulator of anoikis sensitivity.

    Evidence Luciferase reporter validation of miR-124-3p, siRNA knockdown, phospho-FAK/AKT/ERK Western blots, in vivo anoikis/metastasis assays in PDAC and colorectal cancer

    PMID:29758195 PMID:29988949

    Open questions at the time
    • The ECM ligand triggering these cascades not identified in these studies
    • Contribution of ITGB1 partner versus ITGA3 alone not separated
  6. 2019 Medium

    Connected ITGA3 to EMT-driving FAK/PI3K/AKT and FAK/Src pathways and to autophagy regulation, broadening its signaling repertoire.

    Evidence Luciferase reporter assays, knockdown, EMT marker and pathway Western blots in bladder and papillary thyroid cancer

    PMID:30614803 PMID:30941771

    Open questions at the time
    • Mechanistic link between ITGA3 and autophagy machinery not defined at this stage
    • Direct versus indirect EMT regulation unresolved
  7. 2020 Medium

    Identified the first direct physical partner beyond the integrin beta chain, VASP, tying ITGA3 to cytoskeletal regulation of stemness.

    Evidence Reciprocal co-immunoprecipitation, immunofluorescence, sphere formation and migration assays in breast cancer

    PMID:31987909

    Open questions at the time
    • Structural basis and stoichiometry of the ITGA3-VASP interaction unknown
    • Whether VASP binding is ligand-engagement dependent not tested
  8. 2021 Medium

    Implicated ITGA3 in viral biology, indicating a role at the membrane in HIV-1 production in macrophages.

    Evidence Gene expression profiling, siRNA knockdown, and viral replication assays in macrophages

    PMID:34242748

    Open questions at the time
    • Mechanism at viral budding/release stage inferred but not directly demonstrated
    • Whether ITGA3 acts as adhesion receptor or scaffold in this context unknown
  9. 2022 Medium

    Established direct transcriptional control of ITGA3 by YY1 and linked the axis to FAK phosphorylation and cytoskeletal remodeling in trophoblast invasion.

    Evidence ChIP-seq, ChIP, dual-luciferase reporter, gene silencing, and immunofluorescence in trophoblastic cells

    PMID:35970081

    Open questions at the time
    • Whether YY1 regulation operates outside trophoblasts not addressed
    • Upstream signals controlling YY1 in this context unresolved
  10. 2024 Medium

    Identified physiological ECM ligands and a receptor-tyrosine-kinase co-receptor, converting ITGA3 from an inferred adhesion molecule into a defined signaling receptor for collagen I and a MET partner driving glycolysis and proliferation.

    Evidence ITGA3 blocking antibody, Col1 siRNA, MET phospho-Western blots, glycolysis assays, co-IP, and xenografts in PDAC and papillary thyroid cancer

    PMID:39690180 PMID:40138447

    Open questions at the time
    • Whether collagen I binds α3β1 directly or requires accessory factors not fully resolved
    • Structural interface of ITGA3-MET cooperation unknown
  11. 2024 Medium

    Demonstrated a tissue-protective progenitor-maintenance role for ITGA3 in neural and alveolar stem cells through ROS-sensitive FAK/YAP signaling and an autophagy/ULK1 axis in trophoblasts.

    Evidence Conditional Itga3 overexpression/knockdown, ICH and CS-exposed mouse models, alveolar organoids, RNA-seq, ULK1 assays, NAC intervention

    PMID:38367510 PMID:38755258 PMID:39437445 PMID:41270956

    Open questions at the time
    • How ROS suppresses ITGA3 expression mechanistically unresolved
    • Whether ECM ligand engagement is required for progenitor maintenance not isolated
  12. 2024 Medium

    Revealed ITGA3 mRNA stability control by the S100A16-MOV10 axis, adding a post-transcriptional input distinct from miRNA repression.

    Evidence Co-IP (S100A16-MOV10), RNA immunoprecipitation (MOV10-ITGA3 mRNA), and actinomycin D stability assay in lung adenocarcinoma

    PMID:39450567

    Open questions at the time
    • Sequence elements in ITGA3 mRNA bound by MOV10 not mapped
    • Generality across tissues unknown
  13. 2025 Medium

    Positioned ITGA3 in immune evasion and additional ECM/transcriptional circuits, identifying it as a Siglec-10 glyco-ligand, a SOX10-IRF1 effector, and a STAT3 target, and detailing NPNT-mediated YAP1 stabilization.

    Evidence Ligand identification, monoclonal antibody blockade, phagocytosis assays, genetic epistasis, FAK inhibitor and Escin treatments, NPNT mouse models, laminin-332 neutralization across PDAC, melanoma, gastric cancer and fibrosis

    PMID:40444575 PMID:40808260 PMID:41881953 PMID:42240927

    Open questions at the time
    • Sialylation enzymes generating the Siglec-10 epitope on α3β1 not defined
    • Interplay between the many parallel ITGA3 axes within a single cell unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the diverse ligand engagements, partner interactions, and transcriptional/post-transcriptional inputs are integrated into context-specific ITGA3 outputs, and the structural basis of its non-canonical partnerships, remain unresolved.
  • No structural model of ITGA3 ligand or co-receptor interfaces in the corpus
  • No causative human Mendelian disease mutation documented in the timeline
  • Quantitative hierarchy among competing regulatory inputs unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 3 GO:0098631 cell adhesion mediator activity 3 GO:0048018 receptor ligand activity 1
Localization
GO:0005886 plasma membrane 3 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-1266738 Developmental Biology 3 R-HSA-1474244 Extracellular matrix organization 2 R-HSA-168256 Immune System 2
Partners
ITGB1METMOV10NPNTSIGLEC10VASP
Complex memberships
integrin alpha3beta1

Evidence

Reading pass · 27 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1990 ITGA3 (Gap-B3) was identified as a member of the integrin superfamily by cDNA cloning and amino acid sequencing. The protein consists of two polypeptide chains (Mr=110,000 and 30,000) connected by disulfide bonds, derived from a precursor by proteolytic cleavage, and contains metal-binding sequences, a transmembrane domain near C-terminus, and matched cysteine residue positions characteristic of integrin alpha subunits. cDNA cloning, protein purification, partial amino acid sequencing, Southern/Northern hybridization The Journal of biological chemistry High 1691184
2013 Exosomal ITGA3 from prostate cancer cells promotes migration and invasion of non-cancerous prostate epithelial cells (prEC); inhibition of exosomal ITGA3 almost completely abolished this effect, establishing a paracrine/exosomal mechanism by which ITGA3 remodels surrounding non-cancerous cells. Exosome isolation by ultracentrifugation, transwell migration/invasion assay, LC-MS/MS proteomics, Western blotting, FACS uptake assay, ITGA3 inhibition Journal of extracellular vesicles Medium 24371517
2015 ITGA3 and ITGB1 are direct targets of miR-223 in prostate cancer cells; knockdown of ITGA3 and ITGB1 significantly inhibited cancer cell migration and invasion, placing ITGA3 downstream of miR-223 in a signaling axis controlling cell motility. miRNA restoration, siRNA knockdown, in silico database analysis, genome-wide gene expression, transwell migration/invasion assays Cancer science Medium 26509963
2017 ITGA3 is a direct target of all members of the miR-199 family (miR-199a-5p, miR-199a-3p, miR-199b-5p, miR-199b-3p) in head and neck squamous cell carcinoma; knockdown of ITGA3 significantly inhibited cancer cell migration and invasion. Ectopic miRNA expression, in silico database and genome-wide gene expression analyses, siRNA knockdown, transwell migration/invasion assays Cancer science Medium 28612520
2017 ITGA3 is a validated target of miR-101 in nasopharyngeal carcinoma; ITGA3 restoration rescued the suppressive effects of miR-101 on migration, invasion, and angiogenesis in vitro and metastasis in vivo using the chicken chorioallantoic membrane model. Ectopic miRNA expression, ITGA3 rescue experiment, in vitro migration/invasion assays, in vivo chorioallantoic membrane angiogenesis/metastasis model Cell death & disease Medium 28102841
2017 In the developing inner ear, miR-183 directly represses ItgA3; this miR-183/ItgA3 axis controls cell proliferation in the developing cochlea, and loss of Dicer (impairing miRNA biogenesis) leads to failure of cochlear progenitors to exit the cell cycle, a phenotype linked to ItgA3 accumulation. Conditional Dicer knockout in otocyst, miRNA target identification, unbiased genomic approach Cell death and differentiation Medium 28777373
2018 ITGA3 and ITGB1 are directly regulated by miR-124-3p in pancreatic ductal adenocarcinoma cells (validated by luciferase reporter assay); knockdown of ITGA3/ITGB1 suppressed migration and invasion and inhibited phosphorylation of FAK, AKT, and ERK, placing ITGA3 upstream of these oncogenic signaling pathways. Luciferase reporter assay, siRNA knockdown, transwell migration/invasion assays, Western blot for phospho-FAK/AKT/ERK Oncotarget Medium 29988949
2018 ITGA3 is a direct target of miR-124 in colorectal cancer (experimentally validated); ITGA3 plays a critical role in regulating anoikis sensitivity of CRC cells, with ITGA3 expression promoting anoikis resistance and facilitating metastasis in vivo. In silico analysis, experimental target validation, overexpression/knockdown functional assays, in vivo anoikis/metastasis assays Biochemical and biophysical research communications Medium 29758195
2019 miR-124-3p directly targets ITGA3 in bladder cancer (confirmed by luciferase reporter assay); ITGA3 knockdown inhibited tumor cell migration and invasion, and ITGA3 mediates its effects through FAK/PI3K/AKT and FAK/Src signaling pathways and modulation of EMT markers (N- and E-cadherin). Luciferase reporter assay, siRNA knockdown, wound healing and transwell assays, Western blot for FAK/PI3K/AKT/Src pathway proteins and EMT markers Cancer biomarkers Medium 30614803
2019 miR-524-5p directly targets ITGA3 in papillary thyroid cancer (experimentally validated); downregulation of ITGA3 by miR-524-5p disturbs the autophagy pathway, inhibiting cancer cell viability, migration, invasion, and apoptosis. Direct target validation, functional cell viability/migration/invasion assays, pathway analysis Journal of cellular physiology Medium 30941771
2020 ITGA3 interacts with VASP in breast cancer cells (confirmed by co-immunoprecipitation and immunofluorescence); ITGA3 regulates VASP expression, and the ITGA3-VASP complex modulates breast cancer cell stemness, EMT, and PI3K-AKT pathway activity. Co-immunoprecipitation, immunofluorescence, Western blot, sphere formation assay, transwell and wound healing assays Gene Medium 31987909
2021 CD9 and ITGA3 are upregulated in macrophages upon HIV-1 infection; downregulation of these genes decreased HIV-1 replication in macrophages, suggesting ITGA3 supports viral production most likely at the level of viral budding and release. Gene expression profiling, siRNA knockdown, viral replication assays in macrophages Virology Medium 34242748
2022 Transcription factor YY1 directly binds to the promoter region of ITGA3 and regulates its mRNA and protein expression in trophoblastic cells; both YY1 and ITGA3 accelerate phosphorylation of focal adhesion kinase (FAK) and affect cytoskeleton formation, modulating trophoblast invasion ability. ChIP-seq, RNA-seq, ChIP experiment, RT-PCR, dual-luciferase reporter gene assay, gene silencing, Western blot, immunofluorescence Journal of reproductive immunology Medium 35970081
2024 Collagen I (Col1) secreted by pancreatic cancer cells acts as a ligand for ITGA3 in an autocrine manner, activating the FAK/PI3K/AKT/mTOR signaling pathway and thereby increasing expression of HIF1α and c-Myc to drive glycolysis; blockade of Col1 by siRNA or ITGA3 by a blocking antibody inactivated this pathway and impaired malignant tumor behaviors. Functional assays (growth, metastasis), siRNA knockdown of Col1, blocking antibody against ITGA3, Western blot for FAK/PI3K/AKT/mTOR/HIF1α/c-Myc, glycolysis assays Cancer gene therapy Medium 39690180
2024 ITGA3 interacts with the MET receptor tyrosine kinase in papillary thyroid cancer (confirmed by co-immunoprecipitation and immunofluorescence); ITGA3-MET cooperation leads to MET phosphorylation at Tyr1234/1235 and activation of ERK and PI3K/AKT signaling pathways, promoting PTC proliferation and migration in vitro and in vivo. Co-immunoprecipitation, immunofluorescence, Western blot for MET phosphorylation and downstream pathway activation, cell functional assays, xenograft models Annals of medicine Medium 40138447
2024 Iron accumulation elevates reactive oxygen species (ROS) which downregulates Itga3 expression in hippocampal neural stem cells (NSCs); reduced Itga3 leads to excessive NSC activation, depletion of the NSC pool, diminished neurogenesis, and cognitive dysfunction after intracerebral hemorrhage. Conditional overexpression of Itga3 in NSCs attenuated these defects. Mouse ICH model, iron chelation, ROS scavenging, conditional Itga3 overexpression in NSCs, neurogenesis assays, cognitive behavioral tests Redox biology Medium 38367510
2024 ITGA3 knockdown in trophoblast cells suppresses ULK1 expression, impairing autophagy initiation and inhibiting trophoblast cell invasion and migration, contributing to recurrent spontaneous abortion pathology; ITGA3 regulates ULK1-mediated autophagy to influence trophoblast function. ITGA3 knockdown, RNA sequencing, ULK1 expression assays, autophagy assays, migration/invasion assays, mouse RSA model American journal of physiology. Cell physiology Medium 39437445
2024 S100A16 binds to MOV10 (confirmed by co-immunoprecipitation) and positively modulates MOV10 expression in lung adenocarcinoma cells; MOV10 in turn stabilizes ITGA3 mRNA (confirmed by RNA immunoprecipitation and actinomycin D assay), regulating ECM-receptor interactions and promoting malignant progression. Co-immunoprecipitation (S100A16-MOV10), RNA immunoprecipitation (MOV10-ITGA3 mRNA), actinomycin D mRNA stability assay, knockdown/overexpression functional assays Molecular medicine reports Medium 39450567
2024 ITGA3 regulates AT2 cell self-renewal through the FAK/YAP axis in COPD; cigarette smoke-induced ROS accumulation suppresses ITGA3, leading to impaired FAK/YAP signaling and AT2 progenitor dysfunction; ROS scavenging with NAC restored ITGA3 expression, reactivated FAK/YAP signaling, and ameliorated emphysematous pathology. scRNA-seq, chronic CS-exposed murine model, alveolar organoids, ITGA3 genetic manipulation, pharmacological NAC intervention, immunostaining Journal of advanced research Medium 41270956
2024 ITGA3 is identified as a driver of early-stage lung adenocarcinoma in a KRAS-mutant AT2 injury/plasticity state; ITGA3 is co-expressed with SRC in AT2KRAS cells, and combined KRASG12D and SRC inhibitors impaired AT2KRAS organoid growth, placing ITGA3 in a KRAS-ITGA3-SRC signaling axis. scRNA-seq from organoids, mice, and stage-IA LUAD patients; KRASG12D and SRC inhibitor treatment of AT2 organoids The EMBO journal Medium 38755258
2025 NPNT (nephronectin) interacts with ITGA3 and through this interaction inhibits LATS1/MOB1 hyperactivation, facilitates YAP1 nuclear translocation, and suppresses YAP1 ubiquitination and degradation, thereby regulating cellular senescence in alveolar epithelial cells and modulating pulmonary fibrosis. NPNT-ITGA3 interaction assays, YAP1 nuclear translocation imaging, ubiquitination assays, LATS1/MOB1 phosphorylation Western blot, NPNT overexpression/knockout mouse models, pharmacological Escin treatment Advanced science Medium 40444575
2025 ITGA3 is identified as a proximal interactor of the RPARPAR CendR peptide/NRP-1 receptor system; mass spectrometry of proximity-labeled membrane proteins from NRP-1-positive cells showed ~20-fold enrichment of ITGA3 (along with ITGAV and ITGB1), suggesting ITGA3 is in spatial proximity to the NRP-1 receptor complex at the cell surface. Proximity labeling with VHP-HRP conjugates, biotin-tyramide covalent labeling of nearby membrane proteins, affinity purification, mass spectrometry bioRxivpreprint Low
2025 Integrin α3β1 (ITGA3/ITGB1) on pancreatic cancer cells is identified as a sialylated glycoprotein ligand for Siglec-10, an inhibitory glyco-immune checkpoint on tumor-associated macrophages; the Siglec-10/α3β1 interaction suppresses macrophage-mediated phagocytosis, and anti-Siglec-10 monoclonal antibodies disrupted this interaction and enhanced anti-tumor immunity in vitro and in mouse models. Ligand identification, monoclonal antibody blockade, macrophage phagocytosis assays, T cell proliferation assays, PDAC xenograft and human Siglec-10 transgenic mouse models bioRxivpreprint Medium
2025 SOX10 knockdown in melanoma upregulates ITGA3 (via IRF1 as an upstream regulator); ITGA3 is essential for cell adhesion and contributes to melanoma metastasis, acting downstream of SOX10-IRF1 in the SOX10-IRF1-ITGA3/EphA2-FAK pathway; FAK inhibitor defactinib significantly reduced metastasis in vivo. siRNA knockdown of SOX10, in silico and in vitro identification of ITGA3/EphA2 as downstream effectors, IRF1 identification as upstream regulator, FAK inhibitor treatment, in vivo metastasis assays Cancer science Medium 40808260
2025 Rab3A directly targets and positively regulates ITGA3 expression (confirmed by dual luciferase assay); ITGA3 stabilization by Rab3A mediates protection against H2O2-induced oxidative stress and mitochondrial dysfunction in inner ear HEI-OC1 cells, as silencing ITGA3 reversed the protective effects of Rab3A. Dual luciferase assay, CCK-8 viability, flow cytometry apoptosis, immunofluorescence mitochondrial membrane potential, oxidative stress and mitochondrial function assays, siRNA knockdown of ITGA3 Journal of bioenergetics and biomembranes Medium 41085878
2026 ITGA3 on PDAC cells acts as a receptor for laminin-332 (LAM332) secreted by cancer-associated fibroblasts (CAFs); CAF-derived LAM332-ITGA3 engagement promotes PDAC cell proliferation, invasion, homotypic CTC clustering, and suppresses apoptosis; neutralization of LAM332 reduced hepatic/pulmonary metastasis and prolonged survival in mouse models. Proteomic and transcriptomic analyses, clinical specimen validation, LAM332 neutralization, CTC clustering assays, apoptosis assays, in vivo mouse metastasis models Cell death & disease Medium 41881953
2026 H. pylori infection induces p-STAT3 activation, which transcriptionally upregulates ITGA3; elevated ITGA3 then activates the NF-κB/mTOR signaling axis and enhances TGF-β-related signaling, promoting gastric cancer cell proliferation, EMT, and migration. H. pylori infection of GC cells, p-STAT3 pathway analysis, ITGA3 expression assays, NF-κB/mTOR and TGF-β pathway Western blots, functional proliferation/migration/EMT assays, in vivo tumor growth Molecular and cellular biochemistry Medium 42240927

Source papers

Stage 0 corpus · 51 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients. Journal of extracellular vesicles 137 24371517
2015 Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer. Cancer science 129 26509963
2017 Regulation of ITGA3 by the anti-tumor miR-199 family inhibits cancer cell migration and invasion in head and neck cancer. Cancer science 112 28612520
2019 MicroRNA-124-3p suppresses cell migration and invasion by targeting ITGA3 signaling in bladder cancer. Cancer biomarkers : section A of Disease markers 59 30614803
1990 Characterization through cDNA cloning of galactoprotein b3 (Gap b3), a cell surface membrane glycoprotein showing enhanced expression on oncogenic transformation. Identification of Gap b3 as a member of the integrin superfamily. The Journal of biological chemistry 58 1691184
2017 MicroRNA-101 inhibits invasion and angiogenesis through targeting ITGA3 and its systemic delivery inhibits lung metastasis in nasopharyngeal carcinoma. Cell death & disease 53 28102841
2013 ITGA3 and ITGB4 expression biomarkers estimate the risks of locoregional and hematogenous dissemination of oral squamous cell carcinoma. BMC cancer 49 24006899
2019 MicroRNA-524-5p suppresses the progression of papillary thyroid carcinoma cells via targeting on FOXE1 and ITGA3 in cell autophagy and cycling pathways. Journal of cellular physiology 44 30941771
2020 ITGA3 interacts with VASP to regulate stemness and epithelial-mesenchymal transition of breast cancer cells. Gene 41 31987909
2018 Involvement of anti-tumor miR-124-3p and its targets in the pathogenesis of pancreatic ductal adenocarcinoma: direct regulation of ITGA3 and ITGB1 by miR-124-3p. Oncotarget 41 29988949
2018 A miR-124/ITGA3 axis contributes to colorectal cancer metastasis by regulating anoikis susceptibility. Biochemical and biophysical research communications 33 29758195
2024 Iron/ROS/Itga3 mediated accelerated depletion of hippocampal neural stem cell pool contributes to cognitive impairment after hemorrhagic stroke. Redox biology 32 38367510
2020 MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer. Molecular medicine reports 30 32705201
2014 Proteomic and functional investigation of the colon cancer relapse-associated genes NOX4 and ITGA3. Journal of proteome research 29 25096929
2024 ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner. Cancer gene therapy 19 39690180
2024 Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis. The EMBO journal 18 38755258
2014 Expression profiling using a cDNA array and immunohistochemistry for the extracellular matrix genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in colorectal carcinoma progression and dissemination. TheScientificWorldJournal 17 24737953
2022 Evaluation of ITGA3 as a Biomarker of Progression and Recurrence in Papillary Thyroid Carcinoma. Frontiers in oncology 14 35174063
2020 Interference with circBC048201 inhibits the proliferation, migration, and invasion of bladder cancer cells through the miR-1184/ITGA3 axis. Molecular and cellular biochemistry 13 32789658
2014 Association of ITGA3 gene polymorphisms with susceptibility and clinicopathological characteristics of osteosarcoma. Medical oncology (Northwood, London, England) 13 24381140
2017 The miR-183/ItgA3 axis is a key regulator of prosensory area during early inner ear development. Cell death and differentiation 12 28777373
2022 YY1/ITGA3 pathway may affect trophoblastic cells migration and invasion ability. Journal of reproductive immunology 11 35970081
2021 miRNA-144-5p/ITGA3 Suppressed the Tumor-Promoting Behaviors of Thyroid Cancer Cells by Downregulating ITGA3. Computational and mathematical methods in medicine 11 34938358
2025 ITGA3-MET interaction promotes papillary thyroid cancer progression via ERK and PI3K/AKT pathways. Annals of medicine 9 40138447
2003 Expression of CD18, CD49b, CD49c and CD49e on lens anterior capsules in human cataracts. Eye (London, England) 9 12802345
2023 ITGA3 acts as a purity-independent biomarker of both immunotherapy and chemotherapy resistance in pancreatic cancer: bioinformatics and experimental analysis. Functional & integrative genomics 8 37270717
2023 FTO Knockdown-Mediated Maturation of miR-383-5p Inhibits Malignant Advancement of Pancreatic Cancer by Targeting ITGA3. Biochemical genetics 7 38001392
2021 CD9 and ITGA3 are regulated during HIV-1 infection in macrophages to support viral replication. Virology 7 34242748
2021 A novel ITGA3 homozygous splice mutation in an ILNEB syndrome child with slow progression. Clinica chimica acta; international journal of clinical chemistry 7 34751145
2024 MUC1 promotes cervical squamous cell carcinoma through ERK phosphorylation-mediated regulation of ITGA2/ITGA3. BMC cancer 6 38702644
2022 Characterization and Identification of Aptamers against CD49c for the Detection, Capture, and Release of Cancer Cells. ACS applied bio materials 6 35792891
2010 Lack of association between markers in the ITGA3, ITGAV, ITGA6 and ITGB3 and autism in an Irish sample. Autism research : official journal of the International Society for Autism Research 6 21182210
2022 Aptamer Targets Triple-Negative Breast Cancer through Specific Binding to Surface CD49c. Cancers 5 35326720
2024 S100A16 stabilizes the ITGA3‑mediated ECM‑receptor interaction pathway to drive the malignant properties of lung adenocarcinoma cells via binding MOV10. Molecular medicine reports 4 39450567
2020 [LncRNA NEAT1 regulates proliferation, migration and invasion of tongue squamous cell carcinoma cells by regulating miR-339-5p/ITGA3 axis]. Shanghai kou qiang yi xue = Shanghai journal of stomatology 4 33043343
2025 Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 3 40444575
2025 Oligomeric Proanthocyanidins Reverse Lenvatinib Resistance in Hepatocellular Carcinoma Through ITGA3-Mediated Pathway. Pharmaceuticals (Basel, Switzerland) 2 41011230
2024 ITGA3 participates in the pathogenesis of recurrent spontaneous abortion by downregulating ULK1-mediated autophagy to inhibiting trophoblast function. American journal of physiology. Cell physiology 2 39437445
1998 Loss of VLA-3 (CD49c/CD29) expression in two multidrug resistant Burkitt's lymphoma cell lines. Cancer biotherapy & radiopharmaceuticals 2 10851427
2025 Vitamin A-Enriched Diet Increases Urothelial Cell Proliferation by Upregulating Itga3 and Areg After Cyclophosphamide-Induced Injury in Mice. Molecular nutrition & food research 1 40119798
2025 Expression and clinical significance of ITGA3 in breast cancer. Open medicine (Warsaw, Poland) 1 40181838
2024 Nanoparticles (NPs)-meditated si-lncRNA NONHSAT159592.1 inhibits glioblastoma progression and invasion through targeting the ITGA3/FAK/PI3K/AKT pathway. Metabolic brain disease 1 39570470
2026 CAFs-derived LAM332 promotes CTCs formation and survival via ITGA3 and contributes to the metastasis of pancreatic ductal adenocarcinoma. Cell death & disease 0 41881953
2026 Distinct miR319a identified from Persicaria chinensis mediates cross-kingdom suppression of cervical cancer by targeting ITGA3. Acta biochimica et biophysica Sinica 0 41988664
2026 Multiscale ECM Stiffness Characterization and Quantitative Single-Cell Analysis Reveal ITGA3-Mediated Stiffness-Responsive Subpopulation Dynamics in Papillary Thyroid Carcinoma. Cellular and molecular bioengineering 0 42080141
2026 Erratum: Publisher Correction: Multiscale ECM Stiffness Characterization and Quantitative Single-Cell Analysis Reveal ITGA3-Mediated Stiffness-Responsive Subpopulation Dynamics in Papillary Thyroid Carcinoma. Cellular and molecular bioengineering 0 42080148
2026 Enhanced ITGA3 expression induced by helicobacter pylori infection facilitates gastric cancer progression via NF-κB and Smad4. Molecular and cellular biochemistry 0 42240927
2025 SOX10 Regulates Melanoma Metastasis Through the IRF1-ITGA3/EphA2-FAK Pathway. Cancer science 0 40808260
2025 Rab3A attenuated H₂O₂-induced mitochondrial dysfunction and damage in HEI-OC1 cells by stabilizing ITGA3 expression. Journal of bioenergetics and biomembranes 0 41085878
2025 Dysregulated ITGA3/FAK/YAP axis mediates impaired alveolar type II epithelial cells function in COPD. Journal of advanced research 0 41270956
2025 The role of ITGA3 expression in predicting liver metastasis in patients with epithelial ovarian cancer. BMC medical genomics 0 41286938

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