Affinage

KRT7

Keratin, type II cytoskeletal 7 · UniProt P08729

Length
469 aa
Mass
51.4 kDa
Annotated
2026-06-10
100 papers in source corpus 11 papers cited in narrative 11 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KRT7 (Keratin 7) is a type II keratin whose expression promotes epithelial cancer cell migration, invasion, and epithelial-mesenchymal transition across multiple tumor types (PMID:33416175, PMID:32659254). In ovarian cancer, KRT7 overexpression drives EMT, migration, and proliferation through TGF-β/Smad2/3 signaling and regulates cell-matrix adhesion via integrin-β1/FAK signaling, with knockdown reversing these effects and inhibiting tumor growth in vivo (PMID:33416175). KRT7 transcription is directly activated by forkhead transcription factors: FOXA1 confers pro-proliferative, migratory, and invasive activity and modulates 5-fluorouracil chemosensitivity through KRT7 (PMID:31317696), and FoxM1 binds an AP-2 consensus cis element to regulate KRT7 expression, where KRT7 loss selectively blocks migration without affecting proliferation (PMID:32659254). KRT7 expression is further controlled by a KRT7-AS antisense lncRNA that forms an RNA-RNA hybrid with KRT7 mRNA to raise keratin 7 protein levels and promote proliferation and migration (PMID:26876208); this duplex is stabilized by METTL3-deposited m6A at A877 via IGF2BP1/HuR, while YTHDF1/eEF-1 mediates FTO-regulated translational elongation of KRT7 mRNA methylated at A950, together driving metastasis (PMID:33795252). In pancreatic ductal adenocarcinoma, KRT7 overexpression promotes liver metastasis by stimulating FGF2 secretion, which suppresses cancer-associated fibroblast proliferation and ECM gene transcription through Wnt/β-catenin signaling to establish a prometastatic, ECM-depleted niche (PMID:40011455).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2016 Medium

    Established that KRT7 expression is set post-transcriptionally by an antisense lncRNA, revealing a non-canonical layer of control over a structural keratin.

    Evidence RNA-seq, RNA-RNA hybrid assay, and domain-mapped overexpression of KRT7-AS in gastric cancer cells with proliferation/migration readouts

    PMID:26876208

    Open questions at the time
    • Did not define how the KRT7-AS/KRT7 duplex mechanistically stabilizes the mRNA
    • Limited to gastric cancer context
  2. 2010 Low

    Placed KRT7 downstream of FOXA1 in a transcriptional program, framing the keratin as an effector of a forkhead factor in epithelial cancer invasion.

    Evidence FOXA1 siRNA knockdown with RT-PCR readout of KRT7 mRNA and invasion/migration assays in esophageal squamous cell carcinoma

    PMID:20043065

    Open questions at the time
    • Direct KRT7-driven mechanism not tested—only mRNA correlation with FOXA1
    • Functional phenotypes attributed to FOXA1, not isolated KRT7
  3. 2019 Medium

    Confirmed FOXA1 directly transactivates KRT7 and that KRT7 mediates FOXA1's oncogenic and chemoresistance functions, converting correlation into a causal transcriptional axis.

    Evidence Dual luciferase reporter assay plus gain/loss-of-function epistasis and 5-FU sensitivity assays in gastric cancer cells

    PMID:31317696

    Open questions at the time
    • FOXA1 binding site on the KRT7 promoter not mapped
    • Mechanism by which KRT7 protein alters chemosensitivity unresolved
  4. 2020 Medium

    Defined the downstream signaling through which KRT7 drives EMT and adhesion, linking the keratin to TGF-β/Smad2/3 and integrin-β1/FAK pathways.

    Evidence KRT7 siRNA knockdown with pathway Western blots, migration/proliferation assays, and xenograft model in ovarian cancer

    PMID:33416175

    Open questions at the time
    • Whether KRT7 acts upstream of or in parallel to TGF-β signaling not resolved
    • Direct molecular partners connecting KRT7 to integrin-β1/FAK not identified
  5. 2020 Medium

    Identified a second forkhead activator (FoxM1) acting through an AP-2 cis element and showed KRT7 loss selectively blocks migration, separating its migratory from proliferative roles.

    Evidence ChIP-seq, RNA-seq, qPCR, and KRT7 siRNA knockdown phenotyping in ovarian cancer cells

    PMID:32659254

    Open questions at the time
    • Relationship between FoxM1 and FOXA1 regulation of KRT7 not reconciled
    • Mechanistic basis of migration-specific dependence unexplained
  6. 2020 Low

    Connected an external stimulus to KRT7 induction, showing bacterial infection upregulates KRT7-AS/KRT7 via NF-κB to promote metastasis.

    Evidence RNA-seq, NF-κB pathway analysis, KRT7-AS siRNA depletion, and in vivo lung metastasis model in colorectal cancer with Fusobacterium nucleatum

    PMID:31910722

    Open questions at the time
    • KRT7 protein function not directly tested—effects attributed to KRT7-AS
    • Direct NF-κB target locus not mapped
  7. 2021 Medium

    Resolved the m6A logic governing KRT7, mapping methylation sites and reader complexes that stabilize the KRT7-AS/KRT7 duplex and tune KRT7 translation.

    Evidence Epi-transcriptome analysis, site-specific mutagenesis (A877, A950), RIP/pulldown for IGF2BP1/HuR and YTHDF1/eEF-1, and in vivo lung metastasis in breast cancer

    PMID:33795252

    Open questions at the time
    • Relative contribution of duplex stabilization versus translational elongation to phenotype not dissected
    • Single lab; reader-complex assignments not orthogonally confirmed
  8. 2021 Low

    Extended upstream regulation to a miR-216a/WT1 cascade feeding into KRT7 in pancreatic cancer linked to PI3K/AKT activity.

    Evidence miRNA microarray, transcription reporter for WT1→KRT7, knockdown/overexpression cascade, and in vivo pancreatic tumor model

    PMID:33759343

    Open questions at the time
    • KRT7's mechanistic contribution is indirect within the axis
    • WT1 binding to the KRT7 promoter not directly mapped
  9. 2022 Low

    Showed KRT7 is required for cell-in-cell and cell cluster formation in pancreatic cancer, implicating it in collective cellular organization beyond single-cell migration.

    Evidence KRT7 siRNA knockdown with CIC, cluster, proliferation, migration, and invasion assays in PDAC cell lines

    PMID:35974300

    Open questions at the time
    • No downstream molecular mechanism for CIC formation defined
    • In vivo relevance of cluster formation not tested
  10. 2025 Medium

    Revealed a non-cell-autonomous mechanism whereby KRT7 reshapes the metastatic microenvironment through FGF2-driven CAF and ECM remodeling.

    Evidence KRT7 overexpression in PDAC, orthotopic model, scRNA-seq of CAFs, FGF2 secretion measurement, Wnt/β-catenin analysis, and in vivo FGF2 targeting

    PMID:40011455

    Open questions at the time
    • Mechanism linking intracellular KRT7 to FGF2 secretion not defined
    • Whether this niche remodeling generalizes beyond PDAC liver metastasis unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How KRT7's structural filament role mechanistically connects to its diverse signaling outputs (TGF-β/Smad, integrin/FAK, FGF2/Wnt) remains unresolved.
  • No structural or biophysical link between keratin filament assembly and signaling activation established
  • No direct protein interactors of KRT7 mapped in the corpus
  • Whether signaling effects require filament integrity vs. soluble KRT7 untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 2
Partners
HURIGF2BP1KRT7-ASMETTL3YTHDF1

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 KRT7-AS lncRNA forms an RNA-RNA hybrid with KRT7 mRNA and controls KRT7 expression at both the mRNA and post-transcriptional levels; forced overexpression of the KRT7-overlapping region (but not non-overlapping portions) of KRT7-AS increased keratin 7 protein levels, promoting gastric cancer cell proliferation and migration. RNA sequencing, RNA-RNA hybrid assay, forced overexpression of full-length vs. truncated KRT7-AS constructs, cell proliferation and migration assays Oncogene Medium 26876208
2021 m6A methyltransferase METTL3 methylates KRT7-AS at A877, stabilizing a KRT7-AS/KRT7 mRNA duplex via IGF2BP1/HuR complexes; additionally, YTHDF1/eEF-1 mediates FTO-regulated translational elongation of KRT7 mRNA with methylated A950 in KRT7 exon 6 as the key site, together promoting breast cancer lung metastasis. Epi-transcriptome and transcriptome analyses, m6A site-specific mutagenesis (A877, A950), RIP/pulldown for IGF2BP1/HuR and YTHDF1/eEF-1 complexes, in vivo lung metastasis model Cancer research Medium 33795252
2020 KRT7 overexpression promotes epithelial-mesenchymal transition (EMT), migration, and proliferation of ovarian cancer cells via the TGF-β/Smad2/3 signaling pathway, and also regulates cell-matrix adhesion through integrin-β1-focal adhesion kinase signaling; KRT7 siRNA knockdown reversed these effects and inhibited tumor growth in vivo. CCK8 proliferation assay, wound healing and transwell migration assays, KRT7 siRNA knockdown, Western blotting for TGF-β/Smad2/3 and integrin-β1/FAK pathway components, in vivo xenograft model Oncology reports Medium 33416175
2019 FOXA1 transcriptionally activates KRT7 in gastric cancer cells, as demonstrated by dual luciferase reporter assay; FOXA1 exerts its pro-proliferative, migratory, and invasive functions through KRT7 activation, and knockdown of either FOXA1 or KRT7 increased chemosensitivity to 5-fluorouracil. Dual luciferase reporter assay, gain- and loss-of-function experiments (siRNA/overexpression), cell proliferation/migration/invasion assays, 5-FU sensitivity assay Journal of biological regulators and homeostatic agents Medium 31317696
2010 FOXA1 siRNA treatment of esophageal cancer cells reduced KRT7 mRNA levels, placing KRT7 downstream of FOXA1 in a transcriptional pathway; FOXA1 and LOXL2 siRNAs also reduced invasion and migration of esophageal squamous cell carcinoma (ESCC) cells, suggesting KRT7-expressing ESCCs with lymph node metastasis are driven in part by FOXA1. siRNA knockdown of FOXA1 and LOXL2, RT-PCR for KRT7 mRNA, invasion and migration assays, gene expression profiling of 24 ESCCs International journal of oncology Low 20043065
2020 FoxM1 binds a consensus AP-2 cis element to regulate KRT7 (and KRT5) gene expression in ovarian cancer; KRT7 deficiency specifically prevented cell migration but not proliferation of SK-OV-3 cells. ChIP-seq, RNA-seq, qPCR, Western blot for FoxM1 knockdown effect on KRT7, migration and proliferation assays with KRT7 siRNA knockdown Gene Medium 32659254
2021 miR-216a suppresses WT1 expression, and WT1 promotes KRT7 transcription; silencing KRT7 diminished the oncogenic role of WT1 in pancreatic cancer, and the miR-216a/WT1/KRT7 axis influenced PI3K/AKT pathway activity. miRNA microarray, transcription reporter assay for WT1→KRT7, siRNA/overexpression of miR-216a and WT1, KRT7 knockdown functional assays (proliferation, invasion), in vivo tumor model IUBMB life Low 33759343
2022 KRT7 knockdown in pancreatic cancer cell lines significantly suppressed cell-in-cell (CIC) formation, cell cluster formation, cell proliferation, migration, and invasion. KRT7 siRNA knockdown, CIC formation assay, cell cluster assay, proliferation/migration/invasion assays, qRT-PCR/Western blot/IHC for KRT7 validation BMC cancer Low 35974300
2025 KRT7 overexpression in pancreatic ductal adenocarcinoma cells promotes liver metastasis by stimulating FGF2 secretion, which inhibits cancer-associated fibroblast (CAF) proliferation and ECM-related gene transcription through the Wnt/β-catenin pathway, creating a prometastatic niche with reduced ECM deposition; FGF2 targeting decreased liver metastasis in vivo. KRT7 overexpression in PDAC cells, orthotopic tumor model, scRNA-seq analysis of CAF infiltration, FGF2 secretion measurement, Wnt/β-catenin pathway analysis in CAFs, in vivo FGF2 targeting experiment Scientific reports Medium 40011455
2020 Fusobacterium nucleatum infection upregulates KRT7-AS and KRT7 expression in colorectal cancer cells via NF-κB signaling; KRT7-AS facilitates CRC cell migration by upregulating KRT7, and Fn-induced CRC lung metastasis was attenuated by depletion of KRT7-AS. RNA sequencing, RT-PCR validation, NF-κB pathway analysis, KRT7-AS depletion (siRNA), transwell/wound healing migration assays, in vivo tail-vein lung metastasis model Gut microbes Low 31910722
2009 A rabbit monoclonal antibody (clone BC1) raised against the C-terminus peptide of CK7 was validated to specifically recognize KRT7 protein by Western blotting on HeLa cell lysates and immunohistochemistry on formalin-fixed paraffin-embedded tissues, with staining pattern concordant with the established mouse monoclonal OV-TL 12/30 clone. ELISA peptide screening, Western blotting on HeLa lysates, IHC on FFPE tissues, comparison with reference antibody OV-TL 12/30 Applied immunohistochemistry & molecular morphology Low 19098679

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 Fusobacterium nucleatum promotes colorectal cancer metastasis by modulating KRT7-AS/KRT7. Gut microbes 190 31910722
2006 Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 133 16980943
2016 Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression. Oncogene 129 26876208
2008 Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 127 18587323
2017 SMARCA4-deficient pulmonary adenocarcinoma: clinicopathological, immunohistochemical, and molecular characteristics of a novel aggressive neoplasm with a consistent TTF1neg/CK7pos/HepPar-1pos immunophenotype. Virchows Archiv : an international journal of pathology 117 28555282
2021 N -Methyladenosine Regulates mRNA Stability and Translation Efficiency of KRT7 to Promote Breast Cancer Lung Metastasis. Cancer research 102 33795252
2004 The diagnostic utility of p63, CK5/6, CK 7, and CK 20 in distinguishing primary cutaneous adnexal neoplasms from metastatic carcinomas. Journal of cutaneous pathology 93 14690459
2006 Role of TTF-1, CK20, and CK7 immunohistochemistry for diagnosis of primary and secondary lung adenocarcinoma. The Kaohsiung journal of medical sciences 85 16570563
2004 Expression pattern of CK7, CK20, CDX-2, and villin in intestinal-type sinonasal adenocarcinoma. Journal of clinical pathology 84 15333652
2012 PDX-1, CDX-2, TTF-1, and CK7: a reliable immunohistochemical panel for pancreatic neuroendocrine neoplasms. The American journal of surgical pathology 72 22498824
2019 A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 67 31239549
2015 Utility of five commonly used immunohistochemical markers TTF-1, Napsin A, CK7, CK5/6 and P63 in primary and metastatic adenocarcinoma and squamous cell carcinoma of the lung: a retrospective study of 246 fine needle aspiration cases. Clinical and translational medicine 62 25977750
2012 p63, CK7, PAX8 and INI-1: an optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting system. Histopathology 57 22260386
2009 CK7, CK20, CDX2 and MUC2 Immunohistochemical staining used to distinguish metastatic colorectal carcinoma involving ovary from primary ovarian mucinous adenocarcinoma. Japanese journal of clinical oncology 56 19926591
2021 Low-Grade Oncocytic Tumor of Kidney (CK7-Positive, CD117-Negative): Incidence in a single institutional experience with clinicopathological and molecular characteristics. Human pathology 55 33961838
2020 KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway. Oncology reports 54 33416175
2007 A case series and immunophenotypic analysis of CK20-/CK7+ primary neuroendocrine carcinoma of the skin. Journal of cutaneous pathology 52 18001414
2010 Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis. International journal of oncology 50 20043065
1990 Flow cytometric analysis of DNA content and keratins by using CK7, CK8, CK18, CK19, and KL1 monoclonal antibodies in benign and malignant human breast tumors. Cytometry 47 1696538
2020 FoxM1 promotes the migration of ovarian cancer cell through KRT5 and KRT7. Gene 44 32659254
2014 DOG1, cyclin D1, CK7, CD117 and vimentin are useful immunohistochemical markers in distinguishing chromophobe renal cell carcinoma from clear cell renal cell carcinoma and renal oncocytoma. Pathology, research and practice 41 25596994
2011 Cluster analysis of immunohistochemical profiles delineates CK7, vimentin, S100A1 and C-kit (CD117) as an optimal panel in the differential diagnosis of renal oncocytoma from its mimics. Histopathology 41 21323945
2005 Real-time RT-PCR detection of CK19, CK7 and MUC1 mRNA for diagnosis of lymph node micrometastases in non small cell lung carcinoma. International journal of cancer 41 15729695
2003 Immunoreactivity of cytokeratins (CK7, CK20) and mucin peptide core antigens (MUC1, MUC2, MUC5AC) in adenocarcinomas, normal and metaplastic tissues of the distal oesophagus, oesophago-gastric junction and proximal stomach. Histopathology 36 12877727
2013 A panel of four immunohistochemical markers (CK7, CK20, TTF-1, and p63) allows accurate diagnosis of primary and metastatic lung carcinoma on biopsy specimens. Virchows Archiv : an international journal of pathology 32 24126803
2011 NY-BR-1 and PAX8 immunoreactivity in breast, gynecologic tract, and other CK7+ carcinomas: potential use for determining site of origin. American journal of clinical pathology 32 21846919
2020 Identification of novel biomarkers, MUC5AC, MUC1, KRT7, GAPDH, CD44 for gastric cancer. Medical oncology (Northwood, London, England) 29 32219571
2008 Ber-EP4, CK1, CK7 and CK14 are useful markers for basaloid squamous carcinoma: a study of 45 cases. Head and neck pathology 28 20614292
2019 Reactivity of CK7 across the spectrum of renal cell carcinomas with clear cells. Histopathology 27 30444288
2005 Murine CD200+ CK7+ trophoblasts in a poly (I:C)-induced embryo resorption model. Reproduction (Cambridge, England) 27 16183870
2010 CK7 expression in primary cutaneous squamous cell carcinoma. Journal of cutaneous pathology 26 20528966
2000 CK7 expression in carcinomas of the Waldeyer's ring area. Human pathology 26 11014577
2022 Construction of a novel model based on cell-in-cell-related genes and validation of KRT7 as a biomarker for predicting survival and immune microenvironment in pancreatic cancer. BMC cancer 25 35974300
2018 Diagnostic Utility of SATB2 in Metastatic Krukenberg Tumors of the Ovary: An Immunohistochemical Study of 70 Cases With Comparison to CDX2, CK7, CK20, Chromogranin, and Synaptophysin. The American journal of surgical pathology 25 28914716
2020 TSC/MTOR-mutated eosinophilic renal tumors are a distinct entity that is CK7+/CK20-/vimentin-: a validation study. Human pathology 23 33352195
2019 CK7 expression associates with the location, differentiation, lymph node metastasis, and the Dukes' stage of primary colorectal cancers. Journal of Cancer 23 31258757
2016 Differential Expression of β-Catenin, EGFR, CK7, CK20, MUC1, MUC2, and CDX2 in Intestinal and Pancreatobiliary-Type Ampullary Carcinomas. International journal of surgical pathology 22 27543509
2004 Identical cytokeratin expression pattern CK7+/CK20- in esophageal and cardiac cancer: etiopathological and clinical implications. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 22 14631371
2007 Altered expression of CK7 and CK20 in preneoplastic and neoplastic lesions in ulcerative colitis. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20 18092953
2014 Analysis of clinical characteristics and differential diagnosis of the lung biopsy specimens in 99 adenocarcinoma cases and 111 squamous cell carcinoma cases: utility of an immunohistochemical panel containing CK5/6, CK34βE12, p63, CK7 and TTF-1. Pathology, research and practice 19 25063315
2019 Combined Immunohistochemistry for the "Three 7" Markers (CK7, CD117, and Claudin-7) Is Useful in the Diagnosis of Chromophobe Renal Cell Carcinoma and for the Exclusion of Mimics: Diagnostic Experience from a Single Institution. Disease markers 16 31737127
2018 Immunohistochemical analysis and comparison of napsin A, TTF1, SPA and CK7 expression in primary lung adenocarcinoma. Biotechnic & histochemistry : official publication of the Biological Stain Commission 15 29956575
2012 CK5, CK5/6, and double-stains CK7/CK5 and p53/CK5 discriminate in situ vs invasive urothelial cancer in the prostate. American journal of clinical pathology 15 22904129
2005 Cytokeratin CK 7 and CK 20 expression in pituitary adenomas. Endocrine pathology 15 16299403
2017 Continuous cell supply from Krt7-expressing hematopoietic stem cells during native hematopoiesis revealed by targeted in vivo gene transfer method. Scientific reports 14 28098173
2022 Immunohistochemical expression of CK20, CK7, and CDX2 in colorectal carcinoma in correlation with pathomorphological characteristics. Folia medica 12 35851772
2021 An algorithmic approach utilizing CK7, TTF1, beta-catenin, CDX2, and SSTR2A can help differentiate between gastrointestinal and pulmonary neuroendocrine carcinomas. Virchows Archiv : an international journal of pathology 12 33733343
2019 FOXA1 promotes proliferation, migration and invasion by transcriptional activating KRT7 in human gastric cancer cells. Journal of biological regulators and homeostatic agents 12 31317696
2013 Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma. Journal of cutaneous pathology 12 23590728
2012 CD10+ and CK7/RON- immunophenotype distinguishes renal cell carcinoma, conventional type with eosinophilic morphology from its mimickers. Applied immunohistochemistry & molecular morphology : AIMM 12 22417859
2021 MicroRNA-216a targets WT1 expression and regulates KRT7 transcription to mediate the progression of pancreatic cancer-A transcriptome analysis. IUBMB life 11 33759343
2008 The value of immunohistochemical expression of TTF-1, CK7 and CK20 in the diagnosis of primary and secondary lung carcinomas. Saudi medical journal 11 18626520
2003 The utility of cytokeratins 7 and 20 (CK7/20) immunohistochemistry in the distinction of short-segment Barrett esophagus from gastric intestinal metaplasia: Is it reliable? BMC clinical pathology 11 14651756
2022 A triple-classification for differentiating renal oncocytoma from renal cell carcinoma subtypes and CK7 expression evaluation: a radiomics analysis. BMC urology 10 36096829
2017 A Rare Case of CK20/CK7 Double Negative Merkel Cell Carcinoma. The American Journal of dermatopathology 10 28221211
2012 Expression of KRT7 and WT1 differentiates precursor lesions of Wilms' tumours from those of papillary renal cell tumours and mucinous tubular and spindle cell carcinomas. Virchows Archiv : an international journal of pathology 9 22382985
2012 Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 9 22990554
2023 The utility of p63, CK7, and CAM5.2 staining in differentiating pagetoid intraepidermal carcinomas. Journal of cutaneous pathology 8 37203381
2015 Identification of Bile Duct Paucity in Alagille Syndrome: Using CK7 and EMA Immunohistochemistry as a Reliable Panel for Accurate Diagnosis. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 8 26366614
2011 EGFR/erB-1, HER2/erB-2, CK7, LP34, Ki67 and P53 expression in preneoplastic lesions of bronchial epithelium: an immunohistochemical and genetic study. Virchows Archiv : an international journal of pathology 8 21424799
2009 Characterization and applications of a newly developed rabbit monoclonal antibody to cytokeratin 7 (CK7) for immunohistochemistry. Applied immunohistochemistry & molecular morphology : AIMM 8 19098679
2020 Comparison of Immunohistochemistry Expression of CK7, HMWK and PSA in High-Grade Prostatic Adenocarcinoma and Bladder Transitional Cell Carcinoma. Iranian journal of pathology 7 33391378
2018 KRAS, NRAS and BRAF analysis of ampullary adenocarcinoma classified using CK7, CK20, MUC1 and MUC2. Journal of gastrointestinal oncology 7 30505580
2017 Clinical significance of CK7, HPV-L1, and koilocytosis for patients with cervical low-grade squamous intraepithelial lesions: a retrospective analysis. Human pathology 7 28554573
2017 The Diagnostic Value of TTF-1, P63, HMWK, CK7, and CD56 Immunostaining in the Classification of Lung Carcinoma. Iranian journal of pathology 7 29531543
2012 Evaluation of Barrett's esophagus with CK7, CK20, p53, Ki67, and COX2 expressions using chromoendoscopical examination. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 7 22591041
2021 Cytokeratins (CK7 and CK20) Genes Expression Association with Clinicopathological Indices in Oral Squamous Cell Carcinoma and Dysplastic Oral Epithelium. Reports of biochemistry & molecular biology 6 34277876
2021 The Role of CK7, S100A1, and CD82 (KAI1) Expression in the Differential Diagnosis of Chromophobe Renal Cell Carcinoma and Renal Oncocytoma. Applied immunohistochemistry & molecular morphology : AIMM 5 33605572
2021 Evaluation of hTERT, KRT7, and survivin in urine for noninvasive detection of bladder cancer using real-time PCR. BMC urology 5 33874920
2018 Expression of CK7 and CDKN2 in Cervical Intraepithelial Neoplasia and Correlation with Clinical Outcome. Anticancer research 5 30504376
2010 [Expression and significance of CK7 and CK19 in colon cancer]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 5 20230678
2001 Utility of CK7 and CK20 immunohistochemistry in the detection of synchronous breast and colon carcinoma in a pleural effusion: a case report and supporting survey of archival material. Diagnostic cytopathology 5 11466814
2024 Expression Patterns of Cytokeratins (CK7, CK20, CK19, CK AE1/AE3) in Atypical Endometrial Hyperplasia Coexisting with Endometrial Cancer. International journal of molecular sciences 4 39201770
2022 Differential expression of CK7, CK20, CDX2 in intestinal and pancreatobiliary types of preriampullary carcinoma. Indian journal of pathology & microbiology 4 35074964
2022 Classifying Pulmonary and Urinary High-grade Neuroendocrine Carcinoma by CK7 Immunohistochemistry. Applied immunohistochemistry & molecular morphology : AIMM 4 35603802
2022 CK20/CK7 double-negative Merkel cell carcinoma in situ: A case report. Journal of cutaneous pathology 4 35748574
2015 Spontaneous regression in an ulcerated CK7 positive Merkel cell carcinoma. Indian journal of dermatology, venereology and leprology 4 25751335
2012 Tubular carcinoids of the appendix: the CK7/CK20 immunophenotype can be a diagnostic pitfall. Journal of clinical pathology 4 22461652
2025 KRT7 promotes pancreatic cancer metastasis by remodeling the extracellular matrix niche through FGF2-fibroblast crosstalk. Scientific reports 3 40011455
2024 Aggressive prostatic adenocarcinoma with urothelial-like morphology, with frequent CK7/CK20/HMWK expression and occasional diffuse neuroendocrine features: A clinicopathologic study of 12 cases. Pathology, research and practice 3 38218041
2012 The role of CK7, Ki-67, CD34 and vimentin in the differentiation between biliary atresia and idiopathic neonatal hepatitis in Egyptian cholestatic neonates. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 3 22716208
2011 Expression pattern of CK7 and CK20 in nasal polyps, at patients with chronic rhinosinusitis with nasal polyposis. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 3 22119824
2025 Pancreatic Serous Neoplasm and Metastatic Clear Cell Renal Cell Carcinoma: Diagnostic Pitfalls Resolvable by a Panel of Immunohistochemical Stains to Include PAX8 and CK7 But Not CAIX. The American journal of surgical pathology 2 40096283
2024 Expression of CK7, CK19 and p16 in HPV-mediated oropharyngeal squamous cell carcinoma. PeerJ 2 39619189
2021 Expression of TLE1, INI1, β-catenin, Claudin1, CK7, CK19, SS18 and calponin in synovial sarcoma. Indian journal of pathology & microbiology 2 34673590
2025 Revisiting the use of CK7 and CK20 immunohistochemical stains in pathological diagnoses. Diagnostic pathology 1 40217517
2025 Impact of hormone sensitivity status on aberrant expression of CK7, CK20, CDX2, GATA3 and TTF1 in prostate cancer. Human pathology 1 40714131
2025 iTRAQ-based quantitative proteomics reveals reduced expression of KRT19, KRT7, and PSTDG in cutaneous specimens after kidney transplantation. Scientific reports 1 41006769
2024 Predictive Model of CK7 Expression in Patients With Clear Cell Renal Cell Carcinoma by Combined Multimodal Ultrasound Diagnostic Techniques: A Retrospective Study. Ultrasound in medicine & biology 1 38281886
2024 Clinical significances of TTF-1, neuroendocrine (chromogranin, synaptophysin, CD56), and keratin (pancytokeratin, CK7, CK5/6) marker immunostaining in small cell lung cancer. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 1 39212909
2024 Atractylenolide I regulates colorectal cancer cells' biological processes and glycolysis via KRT7. Pakistan journal of pharmaceutical sciences 1 39799436
2023 Immunohistochemical Staining Characteristics of Low-Grade Invasive Ductal Carcinoma Using the ADH5 Cocktail (CK5/14, P63, and CK7/18): A Potential Interpretative Pitfall. Diagnostics (Basel, Switzerland) 1 37761331
2022 An Immunohistochemical Expression of CK5/6, CK7, and CK20 on Cell Blocks in Metastatic Cervical Lymphadenopathy. International journal of applied & basic medical research 1 36131858
2022 [CK7+/CD117- low grade oncocytic tumor of the kidney: a clinicopathological analysis]. Zhonghua bing li xue za zhi = Chinese journal of pathology 1 36207909
2019 The role of immunohistochemical staining with CK7 in the differential diagnosis of autoimmune hepatitis. Bratislavske lekarske listy 1 31747764
2015 [CK7, CK20, SOX10 and CDX2: expressions and diagnostic values in primary adenocarcinoma of the sinonasal tract]. Zhonghua yi xue za zhi 1 26711206
2025 Evaluation of nuclear pseudoinclusions, GATA3, 34βE12, and GPNMB performances in CK7 diffuse positive clear cell renal cell neoplasms. Human pathology 0 40975181
2024 Quantitative Evaluation by Digital Pathology of Immunohistochemical Expression of CK7, CK19, and EpCAM in Advanced Stages of NASH. Biomedicines 0 38398042
2024 FOXA1/CK7-positive Esophageal Squamous Cell Carcinoma with Aggressive Liver Metastasis. Internal medicine (Tokyo, Japan) 0 38569907
2024 Expression of Survivin, CK7, ASH1, HMGB3, L587S, and CLCA2 in Peripheral Blood of Lung Cancer Patients by Real-Time Polymerase Chain Reaction. Cureus 0 39130876

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