Affinage

KLF4

Krueppel-like factor 4 · UniProt O43474

Length
513 aa
Mass
54.7 kDa
Annotated
2026-06-10
100 papers in source corpus 55 papers cited in narrative 57 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KLF4 is a zinc-finger transcription factor that binds CACCC/GC-rich and methylated-CpG motifs to control cell proliferation, differentiation, and lineage identity across epithelial, vascular, hematopoietic, and pluripotent contexts (PMID:9422764, PMID:28553926). It contains separable functional modules—an activation domain (aa 91–117) and a repression domain (aa 181–388)—and acts as either activator or repressor depending on cellular context and partner availability (PMID:9422764). Through direct promoter occupancy it represses targets such as p53 (enabling RAS-driven transformation), LDHA, MSI2, MAP2K7, and SPARC, and activates targets including NANOG, NDRG2, BMP4, IL-10, and CDKN1C/p57, thereby imposing growth arrest in untransformed cells while supporting tumor maintenance in specific malignancies (PMID:16244670, PMID:19522013, PMID:20215880, PMID:24947925, PMID:27449499, PMID:27872496, PMID:28656310). In pluripotency, KLF4 cooperates synergistically with OCT4 and SOX2 at the NANOG promoter and partners with SOX2 to drive genome-wide epigenetic remodeling during reprogramming (PMID:19522013, PMID:31722212); its DNA-binding domain forms liquid-liquid condensates with NANOG promoter DNA in a CpG-methylation-enhanced manner, providing a biophysical mode of chromatin organization (PMID:34552088). KLF4 activity is tightly gated by post-translational modification and trafficking: PRMT5-mediated arginine methylation blocks VHL-dependent ubiquitination (PMID:26420673), TTLL4/TTLL1 polyglutamylation at Glu381 blocks K48-ubiquitination to sustain reprogramming and embryonic viability (PMID:29593216), PLK1 phosphorylation at Ser234 recruits TRAF6 for stabilizing K63-ubiquitination (PMID:31281496), and ERK phosphorylation at Ser132 triggers XPO1-mediated nuclear export that initiates exit from naive pluripotency (PMID:29526737); a panel of deubiquitinases including USP10 and USP11 further tunes KLF4 protein stability with opposing tumor outcomes (PMID:31748695, PMID:34114341). In vivo, endothelial KLF4 acts redundantly with KLF2 to maintain vascular integrity (PMID:28239661), and cell-type-specific roles extend to macrophage polarization, dendritic cell DC2B lineage determination, and myogenic differentiation (PMID:35942612, PMID:37723138, PMID:40702338).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1998 High

    Established KLF4 as a sequence-specific DNA-binding transcription factor with defined activation and repression modules, answering what kind of molecular activity it carries.

    Evidence Gel mobility shift with recombinant protein plus GAL4 domain-fusion mapping of activation (aa 91–117) and repression (aa 181–388) domains

    PMID:9422764

    Open questions at the time
    • Did not define endogenous target genes
    • No structural basis for the dual activator/repressor switch
  2. 2000 Medium

    Showed KLF4 cooperates with and physically contacts other transcription factors (Sp1, KLF6) at tissue-specific promoters, framing it as a combinatorial regulator rather than a solo factor.

    Evidence EMSA, co-IP, and co-transfection reporter assays at keratin promoters

    PMID:10802067 PMID:10859317

    Open questions at the time
    • Interaction surfaces not mapped
    • In vivo relevance of cooperativity not tested
  3. 2007 High

    Resolved the context-dependence of KLF4–p53 regulation, showing KLF4 represses p53 to enable transformation in cancer cells but induces p53 to arrest VSMC proliferation.

    Evidence Functional genomic screen, ChIP, shRNA, and p53-antisense epistasis across cancer and VSMC systems

    PMID:16244670 PMID:17659301

    Open questions at the time
    • What determines activator-versus-repressor outcome at the p53 promoter is unresolved
    • Cofactors switching directionality not identified
  4. 2011 High

    Placed KLF4 at the core of the pluripotency transcriptional network by demonstrating direct, cooperative activation of NANOG with OCT4 and SOX2.

    Evidence ChIP, EMSA, reporter assays, and knockdown with binding-site mutation in human ESCs

    PMID:19522013

    Open questions at the time
    • Quantitative contribution relative to other pluripotency factors not defined
  5. 2016 High

    Expanded KLF4's tumor-suppressive transcriptional program to metabolism, invasion, and stemness regulators, mapping a set of directly bound targets.

    Evidence ChIP, reporter, and rescue/epistasis for SPARC, LDHA, MSI2, NDRG2, MAP2K7 across cancer models in vitro and in vivo

    PMID:20215880 PMID:24947925 PMID:27449499 PMID:27872496 PMID:28656310

    Open questions at the time
    • Tissue-specific selection of these targets not explained
    • Genome-wide occupancy in each tumor type incomplete
  6. 2017 High

    Defined a methylation-dependent DNA-binding mode, showing KLF4 reads methylated CpG sites to remodel chromatin and activate gene programs.

    Evidence ChIP-seq, ATAC-seq, and R458A zinc-finger mutagenesis with phenotypic rescue in glioblastoma cells

    PMID:28553926

    Open questions at the time
    • How methyl-reading is integrated with unmethylated CACCC binding genome-wide is unclear
  7. 2017 High

    Established the absolute in vivo requirement for endothelial KLF4/KLF2 in vascular integrity and coagulation homeostasis.

    Evidence Inducible endothelial-specific KLF2/KLF4 double-knockout mice with lethal vascular phenotype and allele-dosage epistasis

    PMID:28239661

    Open questions at the time
    • Direct endothelial target genes driving the phenotype not enumerated
    • Division of labor between KLF2 and KLF4 unresolved
  8. 2018 High

    Demonstrated that subcellular localization gates KLF4 function, with ERK-driven S132 phosphorylation and XPO1 export acting as the trigger for exit from naive pluripotency.

    Evidence S132A mutagenesis, XPO1 co-IP, imaging, and differentiation assays in ESCs

    PMID:26050649 PMID:29526737

    Open questions at the time
    • Whether nuclear export drives degradation or sequestration generally is context-dependent and not fully separated
  9. 2019 High

    Built a comprehensive picture of KLF4 protein-stability control through interlocking post-translational modifications and a panel of E3 ligases and deubiquitinases.

    Evidence Co-IP, ubiquitination/methylation/polyglutamylation assays, phosphosite and lysine mutagenesis, knockin and knockout mice (PRMT5, VHL, TTLL4/1, PLK1/TRAF6, USP10, USP11, ATXN3, TRAF7)

    PMID:24388984 PMID:26420673 PMID:29593216 PMID:31281496 PMID:31563563 PMID:31730901 PMID:31748695 PMID:34114341

    Open questions at the time
    • The hierarchy and competition among these modifications in a single cell state is not resolved
    • Stimuli selecting each modification remain partly undefined
  10. 2019 High

    Showed KLF4 stability in stem cells is maintained by direct interaction with pluripotency factors, coupling its half-life to cell identity.

    Evidence Cycloheximide chase, reciprocal Co-IP with NANOG/SOX2/STAT3/Pol II, and differentiation-blocking mutagenesis

    PMID:31221664 PMID:31722212

    Open questions at the time
    • Mechanism linking partner binding to reduced turnover not fully defined
  11. 2021 High

    Provided a biophysical mechanism for KLF4-mediated chromatin organization via methylation-enhanced liquid-liquid phase condensation of its DNA-binding domain.

    Evidence In vitro LLPS reconstitution with purified DBD and methylated vs. unmethylated NANOG promoter DNA

    PMID:34552088

    Open questions at the time
    • In vivo demonstration of KLF4 condensates at endogenous loci is lacking
    • Functional consequence of condensation versus simple binding not separated
  12. 2022 High

    Mapped opposing, cell-type-specific KLF4 functions in tissue fibrosis, inflammation, and immune lineage identity, demonstrating that local context dictates pro- or anti-fibrotic outcomes.

    Evidence Cell-type-specific conditional knockouts in mesenchymal, myeloid, tubular, and DC compartments with defined disease phenotypes and pathway epistasis

    PMID:31337692 PMID:34893592 PMID:37723138 PMID:39147900 PMID:40702338 PMID:46

    Open questions at the time
    • Upstream signals dictating opposite KLF4 outputs across cell types not unified
    • Direct versus indirect targets in several compartments incomplete

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how a single KLF4 protein integrates its modification state, partner availability, and methyl-DNA reading to deterministically choose activation versus repression at a given locus in a given cell type.
  • No unifying model linking PTM combinatorics to target-gene directionality
  • Conflicting reports on KLF4-TERT directionality across tissues unreconciled
  • No genome-wide co-occupancy/condensate map in defined cell states

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 4 GO:0003677 DNA binding 3 GO:0140313 molecular sequestering activity 1
Localization
GO:0005634 nucleus 2 GO:0005654 nucleoplasm 2 GO:0005829 cytosol 2
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-1640170 Cell Cycle 4 R-HSA-1643685 Disease 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-168256 Immune System 3
Partners
NANOGOCT4PRMT5SOX2TRAF6USP10USP11XPO1

Evidence

Reading pass · 57 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 hEZF (KLF4) protein binds specifically to CACCC core sequence motifs by gel mobility shift analysis with purified recombinant protein; acts as a transcriptional repressor in co-transfection experiments (6-fold reduction of CACCC reporter); contains a repression domain mapped to amino acids 181–388 and an activation domain at amino acids 91–117, identified by GAL4 fusion experiments. Gel mobility shift assay with recombinant protein; co-transfection reporter assay; GAL4 domain-fusion mapping The Journal of biological chemistry High 9422764
2000 GKLF/KLF4 and Sp1 bind overlapping sites in the keratin 19 promoter; GKLF has higher binding affinity than Sp1; overexpression of GKLF and Sp1 together drives aberrant K19 expression in pancreatic acinar cells, demonstrating functional cooperation between KLF4 and Sp1 in tissue-specific gene regulation. Co-transfection reporter assay; EMSA; Western blot; immunohistochemistry The Journal of biological chemistry High 10859317
2000 KLF4 (GKLF) and KLF6 (Zf9) physically interact (co-immunoprecipitation), and their co-transfection additively coactivates the human keratin 4 (K4) promoter in esophageal cancer cell lines, demonstrating a direct protein–protein interaction between two Krüppel-like family members. Co-transfection reporter assay; co-immunoprecipitation FEBS letters Medium 10802067
2002 GKLF/KLF4 is induced in vascular smooth muscle cells (VSMCs) by hydroxyl radicals via p38 MAP kinase-, calcium-, and protein-synthesis-dependent pathways; KLF4 overexpression causes growth arrest, increases p21WAF1/Cip1, p27KIP1, and p53 expression, and directly binds the Id3 promoter to suppress Id3 transcription; KLF4 inhibition promotes VSMC proliferation. Differential display; transfection of sense/antisense constructs; promoter-binding assay; cell count and BrdU assays FASEB journal Medium 12087069
2002 GKLF/KLF4 binds the bcn-1 element of the laminin gamma1 (LAMC1) promoter and synergistically activates the promoter together with Sp1; the synergism requires the GKLF activation and DNA-binding domains as well as a permissive promoter context. Yeast one-hybrid screen; EMSA; co-transfection reporter assay with deletion/mutation constructs Nucleic acids research Medium 12034813
2003 TGF-β1 and BMP-2, -4, and -6 each induce KLF4 binding to the TGF-β control element (TCE) in smooth muscle marker gene promoters; KLF4 induction was confirmed by immunocytochemistry and Western blotting, linking TGF-β superfamily signaling to KLF4-mediated regulation of VSMC phenotype. EMSA; reporter assay; immunocytochemistry; Western blot; pharmacological co-treatment experiments The Journal of biological chemistry Medium 12538588
2005 KLF4 was identified in a functional genomic screen as bypassing RAS(V12)-induced senescence; in untransformed cells KLF4 inhibits proliferation, an effect bypassed by cyclin-D1; KLF4 directly represses the p53 promoter (transcriptional repressor activity), thereby enabling RAS(V12)-mediated transformation and resistance to DNA-damage-induced apoptosis; KLF4 depletion from breast cancer cells restores p53 levels and causes p53-dependent apoptosis. Functional genomic screen; reporter assay; chromatin immunoprecipitation; shRNA knockdown; colony transformation assay Nature cell biology High 16244670
2007 KLF4 (GKLF) overexpression increases p53 promoter activity, mRNA, and protein in VSMCs; the growth arrest induced by KLF4 is completely abolished by co-transfection of p53 antisense, establishing that p53 induction is mechanistically essential for KLF4-mediated VSMC proliferation inhibition. Luciferase reporter assay; real-time RT-PCR; Western blot; BrdU FACS; co-transfection epistasis Journal of molecular and cellular cardiology High 17659301
2007 KLF4 binds the IL-10 promoter and directly activates IL-10 transcription in LPS-stimulated RAW264.7 macrophages; KLF4 overexpression increases IL-10 mRNA and protein, whereas antisense KLF4 decreases them. Luciferase reporter assay; EMSA; RT-PCR; ELISA; transfection of sense/antisense constructs Biochemical and biophysical research communications Medium 17719562
2008 KLF4 is a direct transcriptional target of FOXO transcription factors in B cells; forced KLF4 expression in proliferating B cell blasts causes G1 cell cycle arrest in a manner requiring its DNA-binding and transactivation domains; KLF4 knockdown changes expression of known KLF target genes. Retroviral overexpression; B-cell-specific Klf4 conditional knockout; cell cycle analysis; domain-deletion mutants; RT-PCR International immunology Medium 18375530
2008 In intestinal epithelial cells, KLF4 expression in the proliferative crypt compartment is negatively regulated by the transcription factors TCF4 and SOX9, downstream effectors of β-catenin/Tcf signaling; KLF4 rises in villus-differentiated cells and in butyrate-induced differentiation independently of cell fate. In vitro differentiation assays; RT-PCR; Western blot; reporter/co-transfection with dominant negative TCF4/SOX9 Experimental cell research Medium 18977346
2009 KLF4 and PBX1 directly bind the NANOG proximal promoter and an upstream enhancer respectively, activating NANOG transcription in human ESCs; ChIP and EMSA confirmed direct binding; KLF4 cooperates synergistically with OCT4 and SOX2 to transactivate the NANOG promoter; knockdown of KLF4/PBX1 or mutation of their binding sites significantly reduces NANOG promoter activity. ChIP; EMSA; luciferase reporter assay; knockdown; overexpression; co-transfection Stem cells High 19522013
2009 KLF4 induction in endothelial cells by resveratrol and atheroprotective shear stress occurs via a MEK5/MEF2-dependent signaling pathway; KLF4 and KLF2 share regulation through MEK5 activation and regulate 59.2% of the same MEK5-target genes in endothelial cells. Pharmacological inhibition; transcriptional profiling; overexpression; pathway activation by constitutively active MEK5 Biochemical and biophysical research communications Medium 19968965
2009 Id3 and KLF4 (GKLF) interact to regulate VSMC proliferation: KLF4 overexpression reduces Id3 promoter activity and Id3 expression, and Id3-induced VSMC proliferation is abolished by KLF4 co-transfection; Id3 overexpression decreases p53 protein, while KLF4 (which induces p53) counteracts Id3-driven mitogenesis. Co-transfection with sense/antisense constructs; luciferase reporter assay; Western blot; cell proliferation assay Molecular and cellular biochemistry Medium 19618124
2010 KLF4 inhibits lung cancer cell invasion by transcriptionally suppressing SPARC expression; ectopic KLF4 markedly represses SPARC mRNA; knockdown of SPARC recapitulates KLF4-induced anti-invasion activity; restoration of SPARC in KLF4-transfected cells abrogates the anti-invasion effect, placing KLF4 upstream of SPARC in the invasion pathway. Stable transfection; Matrigel invasion assay; gene expression profiling; siRNA knockdown; retroviral SPARC restoration (epistasis) Cancer biology & therapy High 20215880
2014 KLF4 directly binds the LDHA promoter and negatively regulates LDHA transcription; KLF4 overexpression attenuates aerobic glycolysis in pancreatic cancer cells in vitro and in orthotopic mouse models, while KLF4 knockdown has the opposite effect. ChIP; reporter assay; siRNA knockdown; overexpression; metabolic assays in vitro and in vivo Clinical cancer research High 24947925
2014 KLF4 directly activates NANOG promoter by liquid-liquid phase condensation with DNA; the isolated KLF4 DNA-binding domain undergoes biomolecular condensation with a NANOG proximal promoter fragment, enhanced by CpG methylation of a KLF4 cognate site (established in the 2021 study, see below). Luciferase reporter assay; ChIP; immunofluorescence; binding site mutation Nature communications Medium 19522013
2014 PRMT5 methylates KLF4 at arginine residues, inhibiting VHL-mediated ubiquitylation and proteasomal degradation of KLF4, thereby elevating KLF4 protein levels; elevated KLF4 increases p21 transcription and reduces Bax expression; disruption of PRMT5-mediated KLF4 methylation after genotoxic stress abrogates KLF4 accumulation and attenuates cell cycle arrest. Co-immunoprecipitation; ubiquitination assay; mutagenesis of methylation sites; structure-based modelling; Western blot; cell cycle analysis Nature communications High 26420673
2014 Specific lysine residues in the KLF4 N-terminal domain (Lys32, 52, 232, and 252) are critical for proteasomal ubiquitination and degradation of KLF4 protein; mutation of these residues stabilizes the protein. Deletion fragment analysis; site-directed mutagenesis; ubiquitination assay; Western blot; bioinformatics prediction Biochemical and biophysical research communications Medium 24388984
2015 TRAF7 acts as an E3 ubiquitin ligase that targets KLF4 for ubiquitin-mediated degradation; TRAF7 interacts with the KLF4 N-terminus and promotes KLF4 protein turnover, thereby promoting HCC cell migration and invasion; restoration of KLF4 abrogates TRAF7-induced motility. Co-immunoprecipitation; ubiquitination assay; gain/loss of function; in vivo tumor models Cancer letters Medium 31730901
2015 BAALC traps KLF4 in the cytoplasm, preventing its nuclear function; ERK-mediated monocytic differentiation of AML cells is blocked by BAALC through cytoplasmic sequestration of KLF4, establishing that KLF4 nuclear localization is required for its differentiation-promoting function. Co-immunoprecipitation; subcellular fractionation; immunofluorescence; MEK inhibitor treatment; gain/loss of function Leukemia Medium 26050649
2015 p53 and KLF4 directly activate CEBPA gene transcription, establishing a p53-KLF4-CEBPA axis in AML; p53 loss leads to concomitant reduction of KLF4 and CEBPA; restoring p53 function induces CEBPA expression and myeloid differentiation. Reporter assay for CEBPA promoter; Western blot; pharmacological p53 restoration; AML patient sample analysis Clinical cancer research Medium 26408402
2016 KLF4 directly represses MSI2 gene transcription in pancreatic cancer cell lines and mouse models of PDAC, establishing a KLF4/MSI2 regulatory pathway; loss of KLF4 results in MSI2 overexpression, which promotes PDAC proliferation, migration, invasion, and metastasis. ChIP; reporter assay; gain/loss-of-function in vitro and in vivo; molecular biology methods Clinical cancer research Medium 27449499
2016 KLF4 gene is inactivated by DNA methylation in children with T-ALL; loss of KLF4 accelerates NOTCH1-induced T-ALL by enhancing G1-to-S transition; KLF4 directly represses MAP2K7, and KLF4 loss leads to aberrant activation of MAP2K7, JNK, and ATF2 in leukemic cells; JNK inhibitors reduce leukemia cell expansion. DNA methylation analysis; conditional Klf4 knockout mice; cell cycle analysis; ChIP/reporter for MAP2K7 repression; JNK inhibitor treatment in PDX models Leukemia High 27872496
2017 Endothelial-specific double knockout of KLF2 and KLF4 in adult mice causes acute death from myocardial infarction, heart failure, and stroke with profound vascular integrity compromise and dysregulation of the coagulation system; a single allele of either gene is sufficient for survival, establishing absolute requirement for KLF2/4 in endothelial and vascular integrity. Inducible endothelial-specific conditional double knockout mouse model; histology; coagulation assays JCI insight High 28239661
2017 KLF4 expression in perivascular cells promotes a less differentiated state with enhanced ECM (fibronectin) production; genetic inactivation of Klf4 in perivascular cells decreases pre-metastatic niche formation and metastasis; tumor-secreted factors induce perivascular cell phenotypic switching associated with increased KLF4 expression. Perivascular-cell-specific lineage tracing; conditional Klf4 knockout; in vivo metastasis models; immunostaining Nature medicine High 28920957
2017 β-catenin interacts directly with KLF4 in differentiating (but not proliferating) epithelial cells to promote expression of specialized keratins; WNT10A-dependent KLF4-mediated differentiation is required for normal tissue structure and integrity in palmoplantar and tongue epithelia. Co-immunoprecipitation; conditional KO mice (Wnt10a and Klf4 mutants); keratin expression analysis; histology Nature communications High 28589954
2018 KLF4 nuclear export requires ERK activation; ERK phosphorylates KLF4 at S132, triggering interaction with nuclear export factor XPO1 and KLF4 cytoplasmic relocalization; mutation of S132 blocks nuclear export, prevents decline in Nanog/Klf4/Sox2 mRNA, and blocks ESC differentiation, establishing KLF4 relocalization as the first step in exit from naive pluripotency. Live imaging; subcellular fractionation; co-immunoprecipitation with XPO1; site-directed mutagenesis (S132A); ERK inhibitors; differentiation assays Stem cell reports High 29526737
2018 Klf4 polyglutamylation at Glu381 by TTLL4 and TTLL1 during cell reprogramming impedes K48-linked ubiquitination and sustains KLF4 protein stability; CCP1 or CCP6 (deglutamylases) deficiency promotes iPSC induction; Klf4-E381A knockin mice show impaired blastocyst development and embryonic lethality; deletion of TTLL4 or TTLL1 abrogates reprogramming. Site-directed mutagenesis (Glu381Ala knockin mouse); ubiquitination assays; polyglutamylation assays; iPSC reprogramming efficiency; embryo phenotyping Nature communications High 29593216
2018 DDX3X directly interacts with KLF4 mRNA and regulates its splicing; DDX3X depletion in MCF7 cells induces G1 arrest by relieving DDX3X-mediated inhibition of KLF4 expression; KLF4 represses S-phase inducing genes downstream of DDX3X. RNA immunoprecipitation; splicing assay; siRNA knockdown; cell cycle analysis; Western blot FEBS letters Medium 29782654
2019 KLF4 protein stability in embryonic stem cells is maintained through direct interaction with pluripotency transcription factors NANOG, SOX2, and STAT3, which facilitate KLF4 association with RNA Pol II; KLF4 half-life exceeds 24 h in pluripotent cells but drops to <2 h during differentiation; posttranslational modification of KLF4 destabilizes the protein as cells exit pluripotency; mutations preventing this destabilization block differentiation. Homozygous enhancer deletion; protein half-life measurements (cycloheximide chase); co-immunoprecipitation with NANOG/SOX2/STAT3/Pol II; site-directed mutagenesis Genes & development High 31221664
2019 PLK1 (polo-like kinase 1) directly phosphorylates KLF4 at Ser234, causing recruitment of E3 ligase TRAF6 which mediates K63-linked ubiquitination that stabilizes KLF4 protein; KLF4 in turn enhances TRAF6 expression transcriptionally, forming a KLF4-TRAF6 feed-forward loop that promotes tumorigenesis in nasopharyngeal carcinoma. Kinase inhibitor screening; in vitro kinase assay; co-immunoprecipitation; ubiquitination assay; site-directed mutagenesis; xenograft mouse model Theranostics High 31281496
2019 USP10 is a deubiquitinating enzyme for KLF4; USP10 overexpression increases KLF4 protein level by blocking proteasomal degradation; USP10 loss promotes KLF4 degradation and accelerates KrasG12D-driven lung adenocarcinoma; KLF4 facilitates transcription of tumor suppressor TIMP3 by directly binding the TIMP3 promoter. DUB library screen; co-immunoprecipitation; ubiquitination assay; KO mouse (USP10); ChIP; xenograft Cell death and differentiation High 31748695
2019 ATXN3 is a deubiquitinating enzyme for KLF4; ATXN3 binds KLF4 (confirmed by co-immunoprecipitation), mediates KLF4 deubiquitination and protein stabilization, and promotes breast cancer metastasis in a KLF4-dependent manner. DUB library screen (65 enzymes); co-immunoprecipitation; ubiquitination assay; in vitro/in vivo metastasis assays Cancer letters Medium 31563563
2019 KLF4 represses the Dyrk2 gene in CML leukemic stem/progenitor cells; loss of KLF4 elevates DYRK2, which depletes c-Myc protein and activates p53, inhibiting survival and self-renewal; KLF4 deletion severely abrogates BCR-ABL1+ CML maintenance in vivo. Conditional Klf4 gene deletion; gene expression analysis; ChIP (inferred); pharmacological DYRK2 stabilization; murine and human CML stem cell assays Blood Medium 31515251
2019 DDX17 physically associates with KLF4 via KLF4's zinc-finger domain (confirmed by Co-IP and GST-pull down); DDX17 inhibits KLF4 transcriptional activity at target gene promoters (including E-cadherin and MMP2) and blocks KLF4 binding to the MMP2 promoter; DDX17 cannot regulate KLF4 target genes when the KLF4 zinc-finger domain is deleted. Co-immunoprecipitation; GST-pull down; ChIP; reporter assay; KLF4 knockdown epistasis Cell death & disease High 31653828
2019 KLF4 macrophage-specific deletion augments M1 polarization of kidney-infiltrating macrophages, exacerbates glomerular matrix deposition, tubular damage, and kidney fibrosis; this is mediated by KLF4's suppression of TNFα in macrophages, and TNF receptor-1 inhibition abrogates differences between KLF4-deficient and wild-type mice. Conditional myeloid-specific Klf4 and TNFα knockout mice; nephrotoxic serum nephritis and UUO models; histology; TNF receptor-1 inhibitor treatment (epistasis) Journal of the American Society of Nephrology High 31337692
2019 Sox2 and Klf4 function as the reprogramming core in the absence of exogenous Oct4; polycistronic Sox2 and Klf4 cooperatively bind across the genome, leading to epigenetic remodeling of pluripotency genes and gradual activation of the pluripotency network; stoichiometry of Sox2 and Klf4 is essential for efficiency. Polycistronic expression without Oct4; ChIP-seq; ATAC-seq/epigenetic profiling; iPSC reprogramming efficiency assays Cell reports High 31722212
2021 KLF4 DNA-binding domain undergoes liquid-liquid phase condensation (LLPS) with a DNA fragment from the NANOG proximal promoter even in the absence of an intrinsically disordered region; CpG methylation of a KLF4 cognate binding site enhances condensate formation, proposing condensation-based chromatin re-organization. In vitro LLPS assay; fluorescence microscopy; biophysical characterization of condensate properties; methylated vs. unmethylated DNA comparison Nature communications High 34552088
2021 KLF4 KO in PDGFR-β+ mesenchymal cells upregulates TGFβ signaling and promotes fibrosis; in α-SMA+ myofibroblasts, KLF4 reduction non-cell-autonomously exacerbates lung fibrosis via a FOXM1→CCL2/CCR2 pathway inducing macrophage accumulation, demonstrating opposing context-dependent roles of KLF4 in distinct mesenchymal cell types. Cell-type-specific conditional Klf4 knockout; bleomycin lung fibrosis model; transcriptomic analysis; FOXM1/CCL2 pathway analysis Nature communications High 34893592
2021 USP11 deubiquitinates KLF4 by removing K63-linked polyubiquitin chains, thereby destabilizing and degrading KLF4 protein; USP11 interacts with KLF4 (identified by proteomics and confirmed by Co-IP); USP11 depletion inhibits HCC growth by enhancing KLF4 stability. Proteomic approach; co-immunoprecipitation; deubiquitination assay (K63-ubiquitin chain removal); USP11 knockout; in vitro HCC functional assays Journal of cellular and molecular medicine Medium 34114341
2017 KLF4 binds to methylated CpG (mCpG) sites in cis-regulatory elements and promotes chromatin remodeling and transcriptional activation of 116 genes in a methylation-dependent manner in glioblastoma cells; R458A mutation in the KLF4 zinc-finger domain abolishes mCpG-dependent binding and abrogates KLF4-promoted cell adhesion, migration, and morphological changes. ChIP-seq; ATAC-seq; luciferase reporter; site-directed mutagenesis (R458A); cell adhesion/migration assays eLife High 28553926
2017 PARP1 interacts with KLF4 and is required for KLF4 recruitment to the TERT promoter; PARP1 knockdown reduces TERT expression and telomerase activity in cancer and ESCs; the oligo(ADP-ribose) but not poly(ADP-ribose) polymerase activity of PARP1 is required for KLF4-TERT activation. Co-immunoprecipitation; ChIP; PARP1 knockdown; TERT reporter assay; enzymatic activity mutants of PARP1; telomerase activity assay Nucleic acids research High 28985359
2016 KLF4 directly binds the NDRG2 promoter and transcriptionally activates NDRG2; KLF4-mediated inhibition of colorectal cancer cell proliferation is dependent on NDRG2 (rescued by NDRG2 knockdown); KLF4 also upregulates p21WAF1/Cip1 and downregulates cyclin D1. ChIP; luciferase reporter; siRNA knockdown; MTT/EdU/colony assays; xenograft mouse model Oncology reports Medium 28656310
2019 KLF4 promotes self-renewal in CML leukemic stem cells by transcriptionally repressing Dyrk2; KLF4 also promotes transcription of TERT (in cancer/ESC context via PARP1 partnership) and represses hTERT in lung cancer cells by directly binding the hTERT promoter. ChIP; luciferase reporter; gain/loss of function in lung cancer cells and mouse models Oncotarget Medium 27153563
2022 KLF4 directly binds the TERT promoter in alveolar epithelial cells and positively regulates TERT expression and telomerase activity; siRNA-mediated KLF4 knockdown reduces TERT and telomerase activity, while overexpression increases both; KLF4 overexpression via AAV-6 suppresses bleomycin-induced pulmonary fibrosis. ChIP; siRNA knockdown; KLF4 overexpression via AAV-6; TERT reporter; telomerase activity assay; in vivo bleomycin model Cell death & disease Medium 35508454
2022 SENP1 is a SUMO-specific protease that de-SUMOylates KLF4; the SENP1-KLF4 axis regulates LPS-induced M1 macrophage polarization via NF-κB signaling; SUMOylated KLF4 promotes M2 polarization whereas de-SUMOylation (by SENP1) shifts macrophages toward M1. Co-immunoprecipitation; SUMO assay; SENP1 knockdown/overexpression; NF-κB reporter; macrophage polarization markers The FEBS journal Medium 35942612
2022 GCN5 interacts with KLF4 and is recruited to the VEGFA promoter at KLF4-binding sites; GCN5 succinylates H3K79 to epigenetically activate VEGFA transcription and succinylates KLF4 itself (activated by ERK signaling) to increase its transcriptional activity, establishing a KLF4-VEGFA positive feedback loop in endometrial angiogenesis. Co-immunoprecipitation; ChIP; luciferase reporter; succinylation assay; ERK inhibition; siRNA knockdown iScience Medium 35733790
2022 KLF4 directly binds Caspase-1 and Caspase-3 promoters to activate their transcription in renal tubular epithelial cells, promoting pyroptosis; tubular epithelial cell-specific Klf4 knockout alleviates UUO-induced pyroptosis and renal fibrosis; USP11 deubiquitinates and stabilizes KLF4 in this context, and USP11 KO or inhibitor treatment reduces KLF4 levels and fibrosis. Tubular-specific Klf4 KO mice; ChIP for Caspase-1/3 promoters; USP11 KO; mitoxantrone (USP11 inhibitor) treatment; co-immunoprecipitation; Western blot; histology Acta pharmacologica Sinica Medium 39147900
2022 KLF4 directly binds the BMP4 promoter and activates BMP4 transcription (confirmed by ChIP); KLF4 overexpression inhibits fibroblast-to-myofibroblast transdifferentiation in hypertrophic scars in vitro and in vivo, dependent on BMP4 induction. ChIP; reporter assay; KLF4 transfection in vivo and in vitro; myofibroblast differentiation markers International journal of biological sciences Medium 35637963
2023 KLF4 directly binds the PLAC8 promoter and negatively regulates PLAC8 transcription in lung cancer cells (confirmed by ChIP and luciferase reporter); overexpression of PLAC8 partially rescues the growth inhibition caused by KLF4, establishing KLF4/PLAC8 as a functional axis in lung cancer. ChIP; luciferase reporter; KLF4 overexpression; PLAC8 rescue experiment; xenograft Cell death & disease Medium 29789534
2024 KLF4 regulates nuclear translocation of PRMT6 and thereby suppresses H3R2ME2a levels in trophoblast cells; KLF4 forms a KLF4/PRMT6/H3R2ME2a axis that inhibits trophoblast invasion and migration; ChIP confirmed KLF4 binding to PRMT6 promoter; subcellular fractionation showed KLF4 regulates PRMT6 nuclear localization. ChIP; subcellular fractionation; immunofluorescence; H3R2me2a epigenetic profiling; trophoblast invasion/migration assays; in vivo miscarriage mouse model Journal of translational medicine Medium 39390495
2023 In proliferating myoblasts, KLF4 inhibits proliferation by directly binding the P57 (CDKN1C) promoter to activate P57 transcription, causing cell cycle arrest; in differentiating myoblasts, KLF4 promotes fusion by transcriptionally activating Myomixer; muscle-specific KLF4 knockout impairs muscle formation, physical activity, and regeneration. Muscle-specific Klf4 KO mice; ChIP for P57 and Myomixer promoters; reporter assays; gain/loss-of-function in myoblasts; cell cycle analysis; fusion assay Cell death & disease High 37723138
2025 KLF4 expression in pre-DC2 progenitors determines the DC2B (CD7-CD11bhi) lineage; Klf4-specific fate-mapping shows KLF4 separates conventional DC from plasmacytoid DC lineage; conditional Klf4 KO eliminates DC2B subset. Single-cell RNA sequencing; conditional KO; transcription factor fate-mapping; adoptive transfer Nature immunology High 40702338
2023 KLF4 promotes M2 macrophage polarization and mitophagy (upregulating PINK1, Parkin, Bnip3, P62, LC3) in kidney inflammation; silencing KLF4 or mitophagy inhibitor Mdivi-1 reverses paeoniflorin-induced M2 polarization and mitophagy, placing KLF4 upstream of mitophagy in macrophage polarization. siRNA knockdown; pharmacological inhibition (Mdivi-1); mitochondrial membrane potential assay; ROS measurement; macrophage polarization markers; Western blot Phytomedicine Low 37247587
2014 KLF4 directly binds the TERT (hTERT) promoter in ESCs and cancer cells; PARP1 is required for this recruitment and for telomerase activity maintenance; knockdown of PARP1 reduces KLF4 binding to TERT promoter. ChIP; co-immunoprecipitation; PARP1 knockdown; telomerase activity assay Nucleic acids research Medium 28985359
2023 Trained alveolar macrophages upregulate KLF4, which in turn mediates increased MERTK expression; KLF4-driven MERTK upregulation enhances efferocytosis and injury resolution; single-cell mass cytometry and lineage tracing identified expansion of a MERTKhi proresolving AM subset associated with KLF4 expression. Transcriptomic analysis; CyTOF mass cytometry; lineage tracing; KLF4 knockdown; adoptive transfer experiments The Journal of experimental medicine Medium 37615937

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science (New York, N.Y.) 721 23348505
2005 The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nature cell biology 488 16244670
2006 KLF4, p21 and context-dependent opposing forces in cancer. Nature reviews. Cancer 445 16372018
2017 Krüppel-like factor 4 (KLF4): What we currently know. Gene 435 28237823
2017 KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis. Nature medicine 207 28920957
2017 KLF2 and KLF4 control endothelial identity and vascular integrity. JCI insight 201 28239661
1998 Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. The Journal of biological chemistry 166 9422764
2005 KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells. Cancer biology & therapy 164 16357509
2014 A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 162 24947925
2009 Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells. Biochemical and biophysical research communications 147 19968965
2019 KLF4 in Macrophages Attenuates TNFα-Mediated Kidney Injury and Fibrosis. Journal of the American Society of Nephrology : JASN 143 31337692
2015 Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nature communications 132 26420673
2019 The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis. Cell death and differentiation 121 31748695
2017 WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nature communications 110 28589954
2009 KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells. Stem cells (Dayton, Ohio) 110 19522013
2003 Krüppel-like factor 4 (KLF4/GKLF) is a target of bone morphogenetic proteins and transforming growth factor beta 1 in the regulation of vascular smooth muscle cell phenotype. The Journal of biological chemistry 105 12538588
2000 The tissue-dependent keratin 19 gene transcription is regulated by GKLF/KLF4 and Sp1. The Journal of biological chemistry 105 10859317
2014 KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria. The Journal of clinical investigation 103 24812666
2014 Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells. Nature communications 99 24770696
2014 MicroRNA-10b promotes migration and invasion through KLF4 and HOXD10 in human bladder cancer. Oncology reports 97 24573354
2002 Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 81 12087069
2023 Paeoniflorin suppresses kidney inflammation by regulating macrophage polarization via KLF4-mediated mitophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology 74 37247587
2016 The Novel KLF4/MSI2 Signaling Pathway Regulates Growth and Metastasis of Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 72 27449499
2008 KLF4 regulation in intestinal epithelial cell maturation. Experimental cell research 70 18977346
2023 Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis. The Journal of experimental medicine 68 37615937
2021 Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization. Nature communications 68 34552088
2019 ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4. Cancer letters 64 31563563
2015 Osteosarcoma Stem Cells Have Active Wnt/β-catenin and Overexpress SOX2 and KLF4. Journal of cellular physiology 63 26332365
2016 MicroRNA-92a Promotes Colorectal Cancer Cell Growth and Migration by Inhibiting KLF4. Oncology research 60 27131314
2008 KLF4 is a FOXO target gene that suppresses B cell proliferation. International immunology 59 18375530
2019 CD34+KLF4+ Stromal Stem Cells Contribute to Endometrial Regeneration and Repair. Cell reports 58 31141693
2010 KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression. Cancer biology & therapy 57 20215880
2007 Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells. Journal of molecular and cellular cardiology 57 17659301
2000 The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact. FEBS letters 56 10802067
2018 The Role of KLF4 in Alzheimer's Disease. Frontiers in cellular neuroscience 54 30297986
2014 HDAC1 and Klf4 interplay critically regulates human myeloid leukemia cell proliferation. Cell death & disease 50 25341045
2017 KLF4 inhibits colorectal cancer cell proliferation dependent on NDRG2 signaling. Oncology reports 49 28656310
2002 Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1. Nucleic acids research 47 12034813
2018 The novel KLF4/PLAC8 signaling pathway regulates lung cancer growth. Cell death & disease 46 29789534
2018 KLF4 Nuclear Export Requires ERK Activation and Initiates Exit from Naive Pluripotency. Stem cell reports 45 29526737
2018 Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nature communications 43 29593216
2017 PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells. Nucleic acids research 43 28985359
2015 Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia. Clinical cancer research : an official journal of the American Association for Cancer Research 43 26408402
2009 KLF4-dependent, PPARgamma-induced expression of GPA33 in colon cancer cell lines. International journal of cancer 43 19551868
2007 KLF4 regulates the expression of interleukin-10 in RAW264.7 macrophages. Biochemical and biophysical research communications 42 17719562
2017 Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration. eLife 41 28553926
1999 GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk. Mechanisms of development 41 10330488
2021 Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis. Nature communications 40 34893592
2020 LncRNA-Mhrt regulates cardiac hypertrophy by modulating the miR-145a-5p/KLF4/myocardin axis. Journal of molecular and cellular cardiology 40 31982428
2020 KLF4-mediated upregulation of CD9 and CD81 suppresses hepatocellular carcinoma development via JNK signaling. Cell death & disease 40 32350244
2019 A KLF4-DYRK2-mediated pathway regulating self-renewal in CML stem cells. Blood 39 31515251
2018 DDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4. FEBS letters 39 29782654
2022 KLF4 regulates TERT expression in alveolar epithelial cells in pulmonary fibrosis. Cell death & disease 38 35508454
2019 DDX17 promotes hepatocellular carcinoma progression via inhibiting Klf4 transcriptional activity. Cell death & disease 37 31653828
2016 Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway. Leukemia 37 27872496
2022 KLF4 Alleviates Hypertrophic Scar Fibrosis by Directly Activating BMP4 Transcription. International journal of biological sciences 35 35637963
2009 Spatial and temporal expression of KLF4 and KLF5 during murine tooth development. Archives of oral biology 35 19268913
2020 KLF4K409Q-mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment. Acta neuropathologica communications 34 32245394
2019 KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control. Genes & development 34 31221664
2019 Polo-Like Kinase 1 phosphorylates and stabilizes KLF4 to promote tumorigenesis in nasopharyngeal carcinoma. Theranostics 33 31281496
2019 TRAF7 enhances ubiquitin-degradation of KLF4 to promote hepatocellular carcinoma progression. Cancer letters 33 31730901
2019 Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4. Cell reports 32 31722212
2022 SENP1-KLF4 signalling regulates LPS-induced macrophage M1 polarization. The FEBS journal 31 35942612
2016 KLF4 deletion alters gastric cell lineage and induces MUC2 expression. Cell death & disease 31 27277677
2015 Glucocorticoid receptor and Klf4 co-regulate anti-inflammatory genes in keratinocytes. Molecular and cellular endocrinology 31 26001834
2007 Genetic and epigenetic analysis of the KLF4 gene in gastric cancer. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 31 17614846
2017 KLF4 expression enhances the efficacy of chemotherapy drugs in ovarian cancer cells. Biochemical and biophysical research communications 30 28108288
2016 KLF4 downregulates hTERT expression and telomerase activity to inhibit lung carcinoma growth. Oncotarget 30 27153563
2016 Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway. Oncotarget 30 27531889
2015 MiR-375 targets KLF4 and impacts the proliferation of colorectal carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 30 26224477
2018 The Effect and Mechanism of TLR9/KLF4 in FFA-Induced Adipocyte Inflammation. Mediators of inflammation 29 30662369
2023 MiR-7-5p/KLF4 signaling inhibits stemness and radioresistance in colorectal cancer. Cell death discovery 28 36732504
2021 USP11 degrades KLF4 via its deubiquitinase activity in liver diseases. Journal of cellular and molecular medicine 28 34114341
2015 BAALC potentiates oncogenic ERK pathway through interactions with MEKK1 and KLF4. Leukemia 28 26050649
2024 A review of KLF4 and inflammatory disease: Current status and future perspective. Pharmacological research 27 39134187
2023 FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination. Nature communications 27 37660071
2022 Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state. Theranostics 27 36276637
2021 LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C. Nature communications 27 33568674
2023 CircZNF609 regulates pulmonary fibrosis via miR-145-5p/KLF4 axis and its translation function. Cellular & molecular biology letters 26 38105235
2023 miR-126 promotes M1 to M2 macrophage phenotype switching via VEGFA and KLF4. PeerJ 25 37020848
2022 Transcription factor KLF4 regulated STAT1 to promote M1 polarization of macrophages in rheumatoid arthritis. Aging 25 35748767
2021 H. pylori infection induces CXCL8 expression and promotes gastric cancer progress through downregulating KLF4. Molecular carcinogenesis 25 34038586
2025 Transcription factors TCF4 and KLF4 respectively control the development of the DC2A and DC2B lineages. Nature immunology 21 40702338
2021 KLF4 Regulates Metabolic Homeostasis in Response to Stress. Cells 21 33917010
2021 KLF4, Slug and EMT in Head and Neck Squamous Cell Carcinoma. Cells 20 33802627
2015 The transient expression of Klf4 and Klf5 during adipogenesis depends on GSK3β activity. Adipocyte 20 26451280
2023 KLF4 targets RAB26 and decreases 5-FU resistance through inhibiting autophagy in colon cancer. Cancer biology & therapy 19 37431852
2023 KLF4 regulates skeletal muscle development and regeneration by directly targeting P57 and Myomixer. Cell death & disease 19 37723138
2021 The Partial Role of KLF4 and KLF5 in Gastrointestinal Tumors. Gastroenterology research and practice 18 34367275
2013 Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression. Biochemical and biophysical research communications 18 23376074
2024 USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation. Acta pharmacologica Sinica 17 39147900
2023 Role of KLF4/NDRG1/DRP1 axis in hypoxia-induced pulmonary hypertension. Biochimica et biophysica acta. Molecular basis of disease 17 37356737
2019 MiRNA-92a promotes cell proliferation and invasion through binding to KLF4 in glioma. European review for medical and pharmacological sciences 17 31378903
2014 Critical lysine residues of Klf4 required for protein stabilization and degradation. Biochemical and biophysical research communications 17 24388984
2022 DUB3/KLF4 combats tumor growth and chemoresistance in hepatocellular carcinoma. Cell death discovery 16 35383144
2022 MiR-92a/KLF4/p110δ regulates titanium particles-induced macrophages inflammation and osteolysis. Cell death discovery 16 35418181
2022 GCN5 participates in KLF4-VEGFA feedback to promote endometrial angiogenesis. iScience 16 35733790
2021 Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells. FASEB bioAdvances 16 33977234
2024 KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion. Journal of translational medicine 15 39390495
2009 Interaction of Inhibitor of DNA binding 3 (Id3) with Gut-enriched Krüppel-like factor (GKLF) and p53 regulates proliferation of vascular smooth muscle cells. Molecular and cellular biochemistry 15 19618124

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