Affinage

KLF15

Krueppel-like factor 15 · UniProt Q9UIH9

Length
416 aa
Mass
44.0 kDa
Annotated
2026-04-28
100 papers in source corpus 47 papers cited in narrative 47 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KLF15 is a Krüppel-like zinc-finger transcription factor that functions as a master transcriptional coordinator of metabolic homeostasis, linking circadian clock output, hormonal signaling, and nutrient sensing to tissue-specific gene programs governing glucose, lipid, amino acid, and xenobiotic metabolism. It binds GC-rich/CACCC motifs predominantly at gene promoters—and at distal intergenic enhancers in skeletal muscle—where it recruits corepressors (e.g., RIP140 on the Srebf1 promoter with LXR/RXR) or cooperates with tissue-specific partners (MEF2A, Sp1, PPARδ, MRTF-A/B) to activate or repress transcription of targets including GLUT4, gluconeogenic enzymes, SREBP-1c, nephrin/podocin, CTGF, Serpina6/CBG, and phase I–III drug-metabolizing enzymes (PMID:12097321, PMID:35263131, PMID:27545894, PMID:35413288, PMID:32694878, PMID:18586263, PMID:22493483). Its nuclear abundance is tightly regulated by SUMOylation-dependent nuclear retention (reversed by SENP1 under hypoxia), K48-linked polyubiquitination by WWP1 and NEDD4 targeting it for proteasomal degradation, deacetylation by SIRT3, and transcriptional control by circadian (PER3/BMAL1) and insulin/FoxO pathways (PMID:29472234, PMID:30830866, PMID:33687156, PMID:28465484, PMID:29186676, PMID:34988390). Through these mechanisms KLF15 governs circadian nitrogen and bile acid homeostasis, cardiac rhythmic gene output, adipogenesis, podocyte differentiation, skeletal muscle atrophy, hepatic gluconeogenesis, and anti-fibrotic and anti-atherogenic programs across multiple organs (PMID:22405069, PMID:26040986, PMID:26686628, PMID:15664998, PMID:35290243, PMID:20393151, PMID:37984156). A human loss-of-function mutation (p.Lys229*) that abolishes KLF15 transcriptional activity on KChIP2 and CTGF promoters has been linked to cardiac arrhythmia and cardiomyopathy (PMID:33809104).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2002 High

    Establishing KLF15 as a transcriptional activator that cooperates with MEF2A to drive GLUT4 expression answered the fundamental question of how this factor participates in glucose uptake regulation in adipocytes and muscle.

    Evidence Co-IP, promoter mutagenesis, reporter assays, and glucose uptake measurements in adipocytes/muscle cells

    PMID:12097321

    Open questions at the time
    • No genome-wide binding data at this stage
    • Mechanism of insulin-dependent enhancement unresolved
    • No in vivo KO validation of GLUT4 regulation
  2. 2004 High

    Demonstration that KLF15 synergizes with Sp1 to transactivate AceCS2 and is induced by fasting in skeletal muscle established KLF15 as a nutrient-responsive transcription factor linking metabolic state to gene expression.

    Evidence GST pull-down, SL2 reconstitution, promoter mutagenesis, and fasting-induced expression in skeletal muscle

    PMID:14960588

    Open questions at the time
    • No in vivo KO confirmation of AceCS2 regulation
    • Fasting signal transduction pathway to KLF15 not identified
  3. 2005 High

    KLF15 was placed in the adipogenic transcription factor cascade upstream of PPARγ and downstream of C/EBPβ, and its DNA-binding consensus (core CACCC/CGCCCC) was biochemically defined, resolving how it recognizes target promoters.

    Evidence EMSA, DNaseI footprinting, dominant-negative/RNAi/overexpression in adipocyte differentiation, reporter assays

    PMID:15664998 PMID:15963234

    Open questions at the time
    • No crystal structure of KLF15 zinc-finger–DNA complex
    • Full spectrum of adipogenic targets unknown
  4. 2008 High

    The finding that KLF15 blocks P/CAF recruitment to the CTGF promoter—validated in KLF15-KO mice with enhanced cardiac fibrosis—established its anti-fibrotic mechanism and first in vivo cardiac function.

    Evidence ChIP, EMSA, reporter assays, KLF15-KO mice with aortic banding

    PMID:18586263

    Open questions at the time
    • Direct physical contact between KLF15 and P/CAF not demonstrated
    • Anti-fibrotic function not tested in non-cardiac tissues at this point
  5. 2010 High

    Liver-specific KLF15 ablation ameliorated diabetic hyperglycemia by reducing gluconeogenic gene expression, and metformin was shown to work in part by accelerating KLF15 degradation, linking KLF15 to a major diabetes therapeutic mechanism.

    Evidence Liver-specific KO mouse, adenoviral rescue, metformin treatment in hepatocytes and in vivo

    PMID:20393151

    Open questions at the time
    • E3 ligase mediating metformin-induced KLF15 degradation not identified at this stage
    • Relative contribution of KLF15 versus other metformin targets unquantified
  6. 2012 High

    KLF15-KO mice lacking circadian amino acid rhythms and ammonia detoxification, together with ChIP-confirmed binding at nephrin/podocin promoters and podocyte injury phenotypes, revealed KLF15 as both a clock-dependent nitrogen homeostasis coordinator and a podocyte differentiation factor.

    Evidence KLF15-KO mouse metabolite profiling, human circadian study, ChIP in podocytes, LPS/adriamycin injury models

    PMID:22405069 PMID:22493483

    Open questions at the time
    • Clock component(s) directly driving Klf15 transcription not yet identified
    • Genome-wide KLF15 targets in kidney unknown
  7. 2014 High

    Interaction mapping with MRTF-A/B and domain characterization placed the nuclear localization signal within the C-terminal zinc-finger region and demonstrated KLF15 represses MRTF-driven hypertrophic gene programs, while NFATc1 promoter binding linked KLF15 to slow myosin expression.

    Evidence Protein–protein interaction assays, NLS mapping, rAAV cardiac overexpression preventing AngII-induced hypertrophy, C2C12 reporter assays

    PMID:22586493 PMID:24680826

    Open questions at the time
    • Structural basis of KLF15–MRTF interaction unknown
    • Contribution of MRTF repression versus direct transcription in anti-hypertrophy unclear
  8. 2015 High

    KLF15 was shown to govern biphasic cardiac transcriptomic oscillation and circadian ileal Fgf15/bile acid synthesis, establishing it as a nodal connector that translates core clock signals into tissue-specific metabolic rhythms.

    Evidence Cardiomyocyte-specific KLF15 depletion with transcriptomics; systemic and liver-specific KLF15-KO with ileectomy and bile duct catheterization

    PMID:26040986 PMID:26686628

    Open questions at the time
    • How KLF15 partitions cardiac transcriptome into two phases mechanistically unresolved
    • Ileal KLF15 cistrome not mapped
  9. 2016 High

    Discovery that KLF15 forms a complex with LXR/RXR to recruit corepressor RIP140 specifically at the Srebf1 promoter during fasting resolved how a single factor can selectively repress lipogenesis without disrupting LXR-mediated cholesterol homeostasis.

    Evidence Promoter complex analysis, coregulator recruitment assays, in vivo overexpression with lipid specificity controls

    PMID:27545894

    Open questions at the time
    • Structural basis of KLF15–LXR/RXR/RIP140 assembly unknown
    • Whether this complex operates outside liver not tested
  10. 2017 High

    Identification of PER3/BMAL1 as direct transcriptional regulators of Klf15—and KLF15 as a glucocorticoid-inducible repressor of airway smooth muscle hypertrophy—completed the upstream circadian and hormonal input circuitry controlling KLF15 expression.

    Evidence Per3-KO mouse adipogenesis, direct promoter regulation analysis; GR ChIP-seq and KLF15 transcriptomics in human ASM

    PMID:28375666 PMID:29186676

    Open questions at the time
    • Whether BMAL1 binds Klf15 promoter in all tissues unknown
    • KLF15 cistrome in ASM not determined
  11. 2018 High

    The discovery that SENP1-mediated deSUMOylation drives KLF15 nuclear export under hypoxia, relieving Arg2 repression, established SUMOylation as a post-translational switch governing KLF15 subcellular localization and vascular NO signaling.

    Evidence ChIP, subcellular fractionation, SENP1 manipulation, vasodilatation assay in pulmonary artery rings

    PMID:29472234

    Open questions at the time
    • SUMO acceptor lysine(s) on KLF15 not mapped
    • Whether SUMOylation regulates KLF15 in non-vascular contexts unknown
  12. 2019 High

    Identification of WWP1 as the E3 ligase catalyzing K48-linked polyubiquitination of KLF15 in both skeletal muscle and cardiomyocytes resolved how KLF15 protein stability is controlled, linking hyperglycemia-induced WWP1 downregulation to muscle atrophy and post-MI cardiac inflammation.

    Evidence Muscle-specific KLF15-KO, ubiquitination assays specifying K48 linkage, diabetic and MI mouse models, AAV9 rescue

    PMID:30830866 PMID:36593958

    Open questions at the time
    • Direct ubiquitination sites on KLF15 not mapped
    • Relative contributions of WWP1 versus NEDD4 in different tissues not delineated
  13. 2019 High

    Liver-specific KLF15 KO demonstrated regulation of all three phases of xenobiotic metabolism and steroid hormone clearance, massively expanding KLF15's known target repertoire beyond intermediary metabolism and explaining its effects on male fertility and drug sensitivity.

    Evidence Liver-specific KO mice, transcriptomics, viral reconstitution, toxicology and steroid measurements

    PMID:32694878

    Open questions at the time
    • Direct versus indirect target genes within EXM phases not fully distinguished
    • KLF15 binding sites at EXM gene loci not mapped at this stage
  14. 2021 High

    FoxO1/3 were identified as direct transcriptional activators of Klf15 in liver during fasting, and a Piezo1/Ca²⁺ mechanosensing pathway was shown to regulate KLF15 in immobilized muscle, together revealing that KLF15 integrates hormonal (insulin/FoxO) and mechanical (Piezo1/Ca²⁺) inputs.

    Evidence Genome-wide TF screening (TFEL scan), in vivo promoter analysis, FoxO manipulation; Ca²⁺ imaging, muscle-specific KLF15-KO and IL-6-KO, limb immobilization with human validation

    PMID:34988390 PMID:35290243

    Open questions at the time
    • Whether Piezo1–KLF15 axis operates in non-muscle tissues unknown
    • How Ca²⁺ reduction mechanistically activates KLF15 transcription not defined
  15. 2022 High

    The first genome-wide KLF15 cistromes—in liver (promoter-centric, chromatin-opening) and skeletal muscle (distal enhancer-centric, PPARδ-cooperative)—revealed tissue-specific modes of chromatin engagement, with Serpina6/CBG identified as a critical hepatic target whose loss explains inflammatory stress mortality in KLF15-KO mice.

    Evidence ChIP-seq from KLF15-3xFLAG knock-in mice, ATAC-seq, PPARδ ChIP-seq, Co-IP, CBG reconstitution rescue, and inflammatory challenge

    PMID:35263131 PMID:35413288

    Open questions at the time
    • Cistromes in heart, kidney, and adipose tissue still lacking
    • Mechanism by which KLF15 opens chromatin (pioneer factor activity?) not established
  16. 2022 High

    KLF15 was shown to repress Wnt pathway activation and fetal gene reprogramming in the postnatal heart (conserved in human ESC-derived cardiomyocytes) and to suppress atherosclerosis by directly repressing OLR-1 in macrophages, extending its protective roles beyond fibrosis to developmental signaling and lipid-laden foam cell formation.

    Evidence KLF15-KO mice, human KLF15-KO ES cells, engineered human myocardium; AAV-KLF15 in atherosclerosis models with OLR-1 rescue

    PMID:31582141 PMID:37984156

    Open questions at the time
    • Direct KLF15 binding sites at Wnt pathway loci not mapped
    • KLF15 cistrome in macrophages not available
  17. 2023 High

    Identification of FKBP5 as a direct KLF15 target whose local delivery rescues impaired muscle regeneration in KLF15-KO mice established a KLF15–FKBP5 axis in myoblast differentiation, separating regenerative from atrophic KLF15 programs.

    Evidence ChIP at FKBP5 promoter, KLF15-KO muscle injury model, lentiviral FKBP5 rescue

    PMID:37673339

    Open questions at the time
    • How KLF15 simultaneously promotes regeneration (FKBP5) and atrophy (atrogene program) is not reconciled
    • Context-dependent switching mechanism between pro-regenerative and pro-atrophy programs unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • Critical open questions include: the structural basis of KLF15 DNA binding and partner selectivity, the identity of SUMO acceptor and ubiquitin acceptor lysines, whether KLF15 functions as a pioneer factor to open chromatin, how tissue-specific target selection is achieved given nearly ubiquitous expression, and how KLF15 balances opposing pro-atrophic versus pro-regenerative outputs in skeletal muscle.
  • No crystal or cryo-EM structure of KLF15
  • SUMO and ubiquitin acceptor sites unmapped
  • Pioneer factor activity not tested directly
  • Tissue-specific cistromes beyond liver and skeletal muscle unavailable

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 24 GO:0003677 DNA binding 19 GO:0098772 molecular function regulator activity 4
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 1
Pathway
R-HSA-1430728 Metabolism 9 R-HSA-392499 Metabolism of proteins 4 R-HSA-162582 Signal Transduction 3 R-HSA-9909396 Circadian clock 3 R-HSA-9748784 Drug ADME 1
Partners
MEF2AMRTFAMRTFBNEDD4PPARDSENP1SP1WWP1
Complex memberships
KLF15–LXR/RXR/RIP140 corepressor complexKLF15–MEF2A complexKLF15–PPARδ complex

Evidence

Reading pass · 47 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 KLF15 directly binds to a specific KLF15-binding site in the GLUT4 promoter proximal to the MEF2A site, physically interacts with MEF2A (shown by co-immunoprecipitation), and synergistically activates the GLUT4 promoter to increase both basal and insulin-stimulated glucose uptake in adipocytes and muscle cells. Co-immunoprecipitation, promoter deletion/mutational analysis, co-transfection reporter assays, glucose uptake assays The Journal of biological chemistry High 12097321
2004 KLF15 transactivates the AceCS2 gene promoter by binding to the proximal KLF site, and physically interacts with Sp1 (shown by GST pull-down assay), resulting in synergistic activation of the AceCS2 promoter; fasting robustly induces KLF15 expression in skeletal muscle driving AceCS2 expression. Promoter deletion/mutation analysis, luciferase reporter assay, GST pull-down assay, SL2 cell reconstitution, qPCR The Journal of biological chemistry High 14960588
2005 KLF15 plays an essential role in adipogenesis by transcriptionally activating PPARγ2 promoter; acts downstream of C/EBPβ and upstream of PPARγ; KLF15 and C/EBPα synergistically activate the PPARγ2 promoter. Dominant-negative expression, RNA interference, ectopic overexpression, co-transfection promoter assay, microarray The Journal of biological chemistry High 15664998
2005 KLF15 zinc-finger domains bind a 9 bp consensus sequence (core CG/TCCCC) in a zinc-dependent and sequence-specific manner, occupying multiple sites in the rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements, and represses promoter activity driven by CRX and/or NRL. EMSA, DNaseI footprinting, GST fusion protein binding assay, luciferase reporter assay BMC molecular biology High 15963234
2008 KLF15 inhibits basal and TGFβ1-induced CTGF promoter activity in cardiac fibroblasts by blocking recruitment of the co-activator P/CAF to the CTGF promoter without affecting Smad3-DNA binding; KLF15-/- mice subjected to aortic banding show increased CTGF and fibrosis. Adenoviral overexpression, chromatin immunoprecipitation (ChIP), EMSA, luciferase reporter assay, KLF15-/- mouse model Journal of molecular and cellular cardiology High 18586263
2009 KLF15 is a direct transcriptional regulator of the HSD17B5 gene; a KLF15 binding site in the HSD17B5 promoter was identified by EMSA and ChIP; overexpression of KLF15 increased HSD17B5 promoter activity and testosterone formation; insulin increases KLF15 mRNA and thereby promotes HSD17B5 promoter activity. Luciferase reporter assay, EMSA, chromatin immunoprecipitation (ChIP), real-time RT-PCR The Journal of clinical endocrinology and metabolism High 19366843
2009 miR-133 directly targets the 3'UTR of KLF15 mRNA to reduce KLF15 protein levels, resulting in downstream reduction of GLUT4 expression and decreased insulin-mediated glucose uptake in cardiomyocytes. Lentiviral decoy reporter system, forced miR-133 expression, protein level analysis Biochemical and biophysical research communications Medium 19720047
2010 KLF15 regulates hepatic gluconeogenic and amino acid-degrading enzyme gene expression in coordination with PGC-1α; liver-specific KLF15 ablation in diabetic mice reduces gluconeogenic gene expression and ameliorates hyperglycemia; metformin suppresses KLF15 abundance by accelerating its protein degradation and reducing its mRNA, thereby inhibiting gluconeogenesis. Liver-specific KO mouse, adenoviral KLF15 restoration, cultured hepatocyte experiments, metformin treatment Diabetes High 20393151
2010 KLF15 and Sp1 regulate basal transcription of the human LRP5 gene by binding to sites between -72 bp and -53 bp in the LRP5 promoter, as demonstrated by ChIP and Drosophila SL2 cell reconstitution assays. Luciferase reporter assay, chromatin immunoprecipitation (ChIP), Drosophila SL2 reconstitution assay BMC genetics Medium 20141633
2010 KLF11 and KLF15 both interact directly with the UCP1 promoter (KLF15 via GT-boxes); co-transfection of KLF11 and KLF15 enhances UCP1 expression in differentiating brown adipocytes, though KLF11 but not KLF15 is essential for UCP1 expression. Promoter binding assay, co-transfection, gene expression analysis Biochemical and biophysical research communications Medium 20709022
2011 KLF15 expression in uterine epithelium is regulated by progesterone+estrogen and binds the Mcm2 promoter to inhibit MCM2 expression, suppress DNA replication licensing, and block estrogen-induced epithelial cell proliferation; this is accompanied by increased H3 methylation and HDAC1/3 recruitment with H3 deacetylation at the Mcm2 promoter. ChIP, transient transfection reporter assay, in vivo KLF15 expression in estrogenized uterus, flow cytometry/cell cycle analysis Proceedings of the National Academy of Sciences of the United States of America High 22538816
2011 KLF15 expression in mesangial cells is repressed by oxidative stress, TGFβ, and TNF-α; TNF-α-mediated suppression of KLF15 is mediated by TNF receptor-1 and NF-κB; overexpression of KLF15 decreases fibronectin and type IV collagen mRNA levels in mesangial cells. Receptor-specific knockdown, NF-κB pathway analysis, KLF15 overexpression, mRNA quantification Kidney international Medium 21248717
2012 KLF15-deficient mice exhibit absent circadian amino acid rhythms and impaired circadian ammonia-to-urea detoxification, establishing KLF15 as a clock-dependent transcriptional coordinator of nitrogen homeostasis; feeding is the dominant external cue modulating KLF15 rhythm. KLF15-/- mouse model, metabolite profiling, controlled human circadian study Cell metabolism High 22405069
2012 KLF15 is a key regulator of podocyte differentiation; it binds to promoter regions of nephrin and podocin (shown by ChIP), and KLF15-/- mice develop increased proteinuria and podocyte foot process effacement upon injury. ChIP, KLF15-/- mouse model with LPS/adriamycin challenge, overexpression in podocytes, microarray The Journal of biological chemistry High 22493483
2012 KLF15 interacts with myocardin-related transcription factors (MRTF-A and MRTF-B) and strongly represses their transcriptional activity; the nuclear localization signal of KLF15 resides within the C-terminal zinc-finger region; AAV-mediated cardiac overexpression of KLF15 prevents angiotensin II-induced cardiac hypertrophy. Protein-protein interaction assays, nuclear localization signal mapping, rAAV-mediated overexpression in mouse heart, aortic banding model PloS one High 22586493
2013 KLF15 is an essential mediator of ER stress-induced insulin resistance in the liver; KLF15-/- mice show increased ER stress and JNK activation but are protected from hepatic insulin resistance; KLF15 deficiency inhibits mTORC1 activation by amino acids and insulin, maintaining low energy state with increased AMPK phosphorylation and PGC-1α. KLF15-/- mouse model with high-fat diet and pharmacological ER stress, primary hepatocyte experiments, mTORC1/AMPK signaling analysis PloS one High 24167585
2014 KLF15 regulates slow myosin heavy chain (MHC-β/slow) expression by binding to the NFATc1 promoter and inducing NFATc1 activity, thereby mediating calcineurin/NFAT signaling in skeletal muscle. Gene silencing, overexpression, luciferase reporter assay, NFATc1 promoter binding analysis in C2C12 cells Biochemical and biophysical research communications Medium 24680826
2015 KLF15 is an endogenous negative regulator of circadian ileal Fgf15 expression; systemic or ileal Klf15 deficiency disrupts circadian bile acid synthesis, tissue BA levels, and triglyceride/cholesterol absorption; KLF15 directly represses Fgf15 transcription in the ileum (shown by molecular, biochemical, and functional assays including ileectomy and bile duct catheterization). Systemic and liver-specific Klf15-KO mice, ileectomy, bile duct catheterization, biochemical and molecular assays Nature communications High 26040986
2015 KLF15 governs a biphasic transcriptomic oscillation in the heart corresponding to active (maximum ATP production) and resting (remodeling/repair) phases; depletion of KLF15 in cardiomyocytes leads to disorganized oscillatory behavior without phasic partition despite an intact core clock, placing KLF15 as a nodal connector between the core clock and cardiac rhythmic output. Cardiomyocyte-specific KLF15 depletion, transcriptomics, cardiac phenotyping Cell reports High 26686628
2015 Drosophila Klf15 (dKlf15/Bteb2) is expressed exclusively in nephrocytes and is necessary and sufficient for nephrocyte differentiation; it acts upstream of the slit diaphragm gene sticks and stones (sns) and Amnionless in a nephrocyte-restricted differentiation pathway. Loss-of-function genetics, conditional silencing, overexpression, in vivo scavenger function assay in Drosophila PloS one High 26301956
2016 KLF15 forms a complex with LXR/RXR specifically on the Srebf1 promoter during fasting; this complex recruits the corepressor RIP140 instead of coactivator SRC1, reducing SREBP-1c and downstream lipogenic enzyme expression; KLF15 overexpression specifically ameliorates hypertriglyceridemia without affecting LXR-mediated cholesterol metabolism. Promoter complex analysis, corepressor/coactivator recruitment assays, KLF15 overexpression mouse model, reporter assay Cell reports High 27545894
2016 KLF15 binds the promoter of the bovine KLF3 gene at the most proximal GGGG element in the core promoter region (-264 to -76) and promotes KLF3 transcriptional activity, as confirmed by EMSA and ChIP in bovine adipocytes. Adenoviral overexpression, siRNA knockdown, dual-luciferase reporter assay, EMSA, ChIP Gene Medium 29551501
2017 KLF15 promotes chondrogenic differentiation of human MSCs by directly binding to the SOX9 promoter and activating SOX9 expression, as demonstrated by ChIP and promoter activity assays. Lentiviral KLF15 knockdown and overexpression, luciferase reporter assay, ChIP, chondrogenic differentiation assay Biochemical and biophysical research communications Medium 28923246
2017 KLF15 is directly induced by glucocorticoids in primary human airway smooth muscle (ASM) and represses ASM hypertrophy; integration of KLF15 overexpression transcriptome with genome-wide GR and RNA Pol II occupancy identified PLCD1 as both a KLF15-regulated gene and a novel repressor of ASM hypertrophy. GR ChIP-seq, RNA Pol II ChIP-seq, KLF15 overexpression transcriptomics, ASM hypertrophy assay American journal of respiratory cell and molecular biology High 28375666
2017 KLF15 directly binds the promoter of Drd2 (dopamine D2 receptor) and promotes its promoter activity; TNF-α induces KLF15 expression in neurons; KLF15 knockout reduces sensitivity to neuropathic pain induced by CCI and SNI. ChIP, luciferase reporter assay, KLF15-/- mouse model with CCI/SNI neuropathic pain assays Biochemical and biophysical research communications Medium 28830816
2017 KLF15 directly binds the promoter of MMP-3 via ChIP and reduces TNF-α-induced MMP-3 expression at the transcriptional level in human chondrocytes; TNF-α reduces KLF15 expression via p53. ChIP, gene expression analysis, KLF15 overexpression in chondrocytes Journal of interferon & cytokine research Medium 30036111
2017 PER3 and BMAL1 directly regulate Klf15 expression; deletion of Per3 promotes adipogenesis in vivo by a clock output pathway through KLF15, placing KLF15 downstream of the Per3/BMAL1 circadian clock in adipocyte precursor cells. Per3-knockout mouse, in vivo adipogenesis assay, direct promoter regulation analysis, circadian oscillation measurement Cell reports High 29186676
2018 Hypoxia triggers SENP1-mediated deSUMOylation of KLF15 in pulmonary endothelial cells, causing its translocation from nucleus to cytoplasm; SUMOylated (nuclear) KLF15 directly binds and represses the Arg2 promoter (shown by ChIP); loss of nuclear KLF15 upon hypoxia relieves Arg2 repression, reducing NO production. ChIP, subcellular fractionation, KLF15 overexpression, SENP1 manipulation, vasodilatation assay in rat pulmonary artery rings Arteriosclerosis, thrombosis, and vascular biology High 29472234
2019 The E3 ubiquitin ligase WWP1 catalyzes K48-linked polyubiquitination and proteasomal degradation of KLF15; hyperglycemia downregulates WWP1, stabilizing KLF15 protein, which promotes muscle atrophy gene expression in skeletal muscle of diabetic mice. Muscle-specific KLF15 KO mice, WWP1 manipulation, ubiquitination assays, diabetic mouse model JCI insight High 30830866
2019 KLF15 transcriptionally regulates all three phases (I-III) of the endobiotic/xenobiotic metabolism (EXM) system in liver; liver-specific KLF15 KO alters numerous phase I-III target genes, renders animals resistant to bile acid and acetaminophen toxicity, and causes enhanced degradation of testosterone and glucocorticoids, reducing male fertility and blood glucose; viral reconstitution of hepatic KLF15 reverses these phenotypes. Liver-specific KO mice, unbiased transcriptomics, viral reconstitution, toxicology assays, steroid hormone measurement Nature metabolism High 32694878
2019 WWP1 targets KLF15 for K48-linked polyubiquitination and degradation in cardiomyocytes, leading to activation of p65 acetylation and MAPK inflammatory signaling after myocardial infarction; inhibiting WWP1 preserves KLF15 and reduces ischemic cardiac injury. AAV9-mediated gene transfer, ubiquitination assays, adenoviral system, cardiac function analysis post-MI Theranostics High 36593958
2020 HDAC11 interacts with AP-2α to repress KLF15 transcription in renal tubular epithelial cells; HDAC11 inhibition or depletion de-represses KLF15 and blocks pro-fibrogenic responses; KLF15 knockdown re-enables fibrogenesis even when HDAC11 is inhibited. HDAC11 inhibitor (quisinostat), siRNA knockdown, co-immunoprecipitation of HDAC11 with AP-2α, UUO mouse model, cultured RTECs Frontiers in cell and developmental biology High 32363192
2017 SIRT3 directly deacetylates KLF15 (co-localization and direct deacetylation demonstrated); SIRT3-KO mice show aggravated hypertension-induced renal fibrosis; SIRT3 activation through honokiol activates SIRT3-KLF15 signaling to reduce fibronectin and collagen type IV expression in podocytes. SIRT3 KO mice, co-localization assays, deacetylation assay, angiotensin II infusion model, cultured podocytes Oncotarget Medium 28465484
2021 Decreased cytosolic Ca2+ from reduced Piezo1 activity due to limb immobilization activates KLF15 expression in skeletal muscle, which in turn induces IL-6 expression; muscle-specific KLF15 deficiency or systemic IL-6 deficiency protects against immobility-induced muscle atrophy, establishing a Piezo1/KLF15/IL-6 axis. Ca2+ bioimaging, acute Piezo1 disruption in skeletal muscle, muscle-specific KLF15 KO, IL-6 KO, antibody blockade, limb immobilization model, human sample validation The Journal of clinical investigation High 35290243
2021 FoxO1/3 transcription factors directly bind the liver-specific Klf15 promoter (identified by TFEL scan and in vivo promoter analysis) to transcriptionally regulate Klf15; during fasting, attenuated insulin signaling activates FoxOs, which elevate KLF15 to increase amino acid catabolic enzyme expression and suppress SREBP-1c-mediated lipogenesis. Genome-wide transcription-factor screening (TFEL scan), in vivo promoter analysis, FoxO manipulation, hepatic gene expression analysis iScience High 34988390
2021 The KLF15-triggered atrogene program in skeletal muscle is regulated via KLF15 ubiquitination by the E3 ubiquitin ligase NEDD4; obestatin/GPR39 signaling suppresses glucocorticoid-induced muscle atrophy by reducing KLF15 ubiquitination through NEDD4, and cooperates with Akt-mediated FoxO4 phosphorylation. In vivo dexamethasone atrophy model, human myotube experiments, NEDD4 manipulation, KLF15 ubiquitination assays, Akt pathway analysis Journal of cachexia, sarcopenia and muscle Medium 33687156
2022 KLF15 in cardiomyocytes acts upstream of Wnt-pathway signaling to repress fetal reprogramming in the heart; KLF15-/- mice show postnatal activation of distinct Wnt pathways and associated remodeling; KLF15 loss leads to SHISA3 upregulation in vascular cells through Wnt-dependent transcriptional signaling; this pathway is conserved in human KLF15-KO embryonic stem cells and engineered human myocardium. Klf15-KO mice, transcriptomic bioinformatics, human KLF15-KO embryonic stem cells, engineered human myocardium, pressure overload and ischemia models Journal of the American College of Cardiology High 31582141
2022 Hepatocyte KLF15 directly transactivates Serpina6 (encoding corticosteroid-binding globulin, CBG) by binding a palindromic GC-rich motif at the Serpina6 promoter (shown by KLF15 cistrome using 3xFLAG knock-in mice); KLF15 predominantly occupies gene promoters in liver, opens chromatin, and transactivates genes; Klf15-deficient mice have profoundly low CBG, reduced plasma corticosteroid binding capacity, and heightened mortality during inflammatory stress, all rescued by CBG reconstitution. KLF15 cistrome (ChIP-seq using engineered Klf153xFLAG mice), ATAC-seq, Klf15-KO mouse model, CBG reconstitution, inflammatory stress challenge Science advances High 35263131
2022 KLF15 and PPARδ colocalize genome-wide in skeletal muscle, physically interact, and are mutually dependent for transcriptional effects on lipid metabolic target genes; KLF15 binding in skeletal muscle is predominantly at distal intergenic regions and associated with circadian and lipid metabolism genes. KLF15 cistrome (ChIP-seq in vivo), PPARδ ChIP-seq, co-immunoprecipitation, muscle-specific KO, transcriptomics The Journal of biological chemistry High 35413288
2022 SIRT7 facilitates KLF15/Nrf2 signaling to mitigate renal ferroptosis; KLF15 siRNA abolishes rhSIRT7-mediated protection against Ang II-induced ROS generation, lipid peroxidation, and ferroptosis in renal tubular epithelial cells, placing KLF15 downstream of SIRT7 in the anti-ferroptotic pathway. AAV-SIRT7 delivery, KLF15 siRNA, Nrf2 inhibitor, ferroptosis markers (xCT/GPX4), Ang II mouse model Free radical biology & medicine Medium 36334846
2022 Xenopus Klf15 directly binds regeneration enhancers in nephric tubules and stimulates expression of adrenoreceptor alpha 1A (adra1a); inhibition of Klf15 causes failure of nephric tubule regeneration; pharmacological inhibition or activation of Adra1a signaling suppresses or promotes kidney regeneration, respectively. ATAC-seq, H3K27ac ChIP-seq, transcriptomics, Klf15 inhibition, pharmacological manipulation of Adra1a in Xenopus laevis Proceedings of the National Academy of Sciences of the United States of America Medium 35939709
2022 KLF15 in brown adipose tissue is essential for metabolic flexibility; BAT-specific KLF15 loss results in widespread changes in circulating metabolites and severely compromised thermogenesis under high energy demands, demonstrating a role in context-dependent prioritization of lipid, glucose, and amino acid metabolism. BAT-specific KLF15 KO, circulating metabolite profiling, thermogenesis assays under multiple metabolic challenges iScience Medium 36304102
2022 KLF15 directly binds and transcriptionally downregulates OLR-1 (lectin-like oxidized LDL receptor-1) promoter in macrophages, reducing lipid uptake and preventing foam cell formation and atherosclerosis; restoration of OLR-1 reverses the beneficial effects of KLF15 overexpression. AAV-KLF15 overexpression in atherosclerosis mouse models (PCSK9 AAV + HFD and ApoE-/- + HFD), OLR-1 restoration rescue experiment, RT-qPCR, western blot Journal of molecular and cellular cardiology Medium 37984156
2023 KLF15 directly binds the FKBP5 promoter to activate FKBP5 expression; KLF15 KO impairs muscle regeneration after injury; local FKBP5 delivery rescues impaired muscle regeneration in Klf15-KO mice, placing KLF15-FKBP5 as a regulatory axis in myoblast differentiation. Klf15-KO mouse model, ChIP (promoter binding), transcriptome analysis, lentiviral FKBP5 rescue delivery The Journal of biological chemistry High 37673339
2021 Loss-of-function mutation in KLF15 (p.Lys229*) abolishes transcriptional activation of the KChIP2 promoter and transcriptional repression of the CTGF promoter (alone or with TGFβ1) in dual-luciferase assays, demonstrating that KLF15 controls both ion channel and fibrosis gene expression relevant to cardiac arrhythmia and cardiomyopathy. Whole exome sequencing, Sanger sequencing, dual-luciferase reporter assay with mutant KLF15 Genes Medium 33809104
2017 KLF15 directly binds the adrenomedullin gene promoter at the most proximal CACCC element (-70 to -29) and inhibits adrenomedullin transcription in adipocytes, as shown by ChIP and luciferase reporter assay; this was identified through a combination of microarray-based ChIP and gene expression analyses. Microarray-based ChIP, luciferase reporter assay, ChIP in human adipocytes Biochemical and biophysical research communications Medium 19094967
2017 AAV-mediated ectopic expression of KLF15 in rod photoreceptors (where it is normally absent) silences rhodopsin (RHO) expression with limited genome-wide transcriptional perturbations; suppression of a RHO mutant allele by KLF15 corrects the phenotype of a mouse model of retinitis pigmentosa. AAV vector-mediated gene delivery, genome-wide transcriptomics, retinitis pigmentosa mouse model phenotyping, pig RHO silencing JCI insight High 29263295

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Role of Krüppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. The Journal of biological chemistry 267 15664998
2002 The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. The Journal of biological chemistry 198 12097321
2019 Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis. JCI insight 161 30830866
2009 MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes. Biochemical and biophysical research communications 156 19720047
2012 Klf15 orchestrates circadian nitrogen homeostasis. Cell metabolism 114 22405069
2010 Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action. Diabetes 99 20393151
2012 Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation. The Journal of biological chemistry 93 22493483
2008 The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. Journal of molecular and cellular cardiology 85 18586263
2016 KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting. Cell reports 76 27545894
2022 Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling. Free radical biology & medicine 75 36334846
2015 Circadian control of bile acid synthesis by a KLF15-Fgf15 axis. Nature communications 74 26040986
2012 KLF15 negatively regulates estrogen-induced epithelial cell proliferation by inhibition of DNA replication licensing. Proceedings of the National Academy of Sciences of the United States of America 74 22538816
2004 A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2. The Journal of biological chemistry 73 14960588
2015 KLF15 Establishes the Landscape of Diurnal Expression in the Heart. Cell reports 72 26686628
2022 A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy. The Journal of clinical investigation 69 35290243
2017 The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15. Cell reports 68 29186676
2011 Low-protein diet supplemented with ketoacids reduces the severity of renal disease in 5/6 nephrectomized rats: a role for KLF15. Kidney international 61 21248717
2019 LncRNA TTN-AS1 sponges miR-376a-3p to promote colorectal cancer progression via upregulating KLF15. Life sciences 55 31610194
2020 Histone Deacetylase 11 Contributes to Renal Fibrosis by Repressing KLF15 Transcription. Frontiers in cell and developmental biology 53 32363192
2011 Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness. American journal of respiratory cell and molecular biology 53 21257922
2023 Targeting WWP1 ameliorates cardiac ischemic injury by suppressing KLF15-ubiquitination mediated myocardial inflammation. Theranostics 49 36593958
2018 Tanshinol alleviates impaired bone formation by inhibiting adipogenesis via KLF15/PPARγ2 signaling in GIO rats. Acta pharmacologica Sinica 46 29323335
2015 Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes. PloS one 44 26301956
2009 KLF15 Is a transcriptional regulator of the human 17beta-hydroxysteroid dehydrogenase type 5 gene. A potential link between regulation of testosterone production and fat stores in women. The Journal of clinical endocrinology and metabolism 44 19366843
2015 KLF15 in breast cancer: a novel tumor suppressor? Cellular oncology (Dordrecht, Netherlands) 42 25869021
2017 SIRT3-KLF15 signaling ameliorates kidney injury induced by hypertension. Oncotarget 40 28465484
2010 Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15. Biochemical and biophysical research communications 40 20709022
2018 Absence of miR-223-3p ameliorates hypoxia-induced injury through repressing cardiomyocyte apoptosis and oxidative stress by targeting KLF15. European journal of pharmacology 38 30336138
2013 KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. PloS one 37 24167585
2018 Allicin induces beige-like adipocytes via KLF15 signal cascade. The Journal of nutritional biochemistry 36 30423518
2016 Characterization of the promoter region of the bovine long-chain acyl-CoA synthetase 1 gene: Roles of E2F1, Sp1, KLF15, and E2F4. Scientific reports 36 26782942
2012 Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications. PloS one 36 22586493
2021 Activation of PKG-CREB-KLF15 by melatonin attenuates Angiotensin II-induced vulnerability to atrial fibrillation via enhancing branched-chain amino acids catabolism. Free radical biology & medicine 35 34864165
2017 KLF15 Inhibits Cell Proliferation in Gastric Cancer Cells via Up-Regulating CDKN1A/p21 and CDKN1C/p57 Expression. Digestive diseases and sciences 33 28421457
2017 Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway. Frontiers in physiology 32 29118722
2019 Multiple roles of KLF15 in the heart: Underlying mechanisms and therapeutic implications. Journal of molecular and cellular cardiology 30 30831134
2017 Global transcriptome profiling identifies KLF15 and SLC25A10 as modifiers of adipocytes insulin sensitivity in obese women. PloS one 30 28570579
2015 c-Jun regulates adipocyte differentiation via the KLF15-mediated mode. Biochemical and biophysical research communications 28 26692489
2021 Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis. Biology direct 27 34727954
2018 KLF15 promotes transcription of KLF3 gene in bovine adipocytes. Gene 27 29551501
2018 Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium. Arteriosclerosis, thrombosis, and vascular biology 26 29472234
2020 Circular RNA MTO1 Inhibits the Proliferation and Invasion of Ovarian Cancer Cells Through the miR-182-5p/KLF15 Axis. Cell transplantation 25 32731816
2019 KLF15-Wnt-Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart. Journal of the American College of Cardiology 25 31582141
2019 KLF15-activating Twist2 ameliorated hepatic steatosis by inhibiting inflammation and improving mitochondrial dysfunction via NF-κB-FGF21 or SREBP1c-FGF21 pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25 31648561
2017 Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy. American journal of respiratory cell and molecular biology 25 28375666
2016 Tanshinol Rescues the Impaired Bone Formation Elicited by Glucocorticoid Involved in KLF15 Pathway. Oxidative medicine and cellular longevity 25 27051474
2018 Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF‑α. Molecular medicine reports 24 29956764
2016 miR-4262 Promotes Proliferation and Invasion of Human Breast Cancer Cells Through Directly Targeting KLF6 and KLF15. Oncology research 24 27629257
2015 KLF15 is an essential negative regulatory factor for the cardiac remodeling response to pressure overload. Cardiology 24 25633973
2015 KLF15 suppresses cell proliferation and extracellular matrix expression in mesangial cells under high glucose. International journal of clinical and experimental medicine 23 26884948
2021 Obestatin signalling counteracts glucocorticoid-induced skeletal muscle atrophy via NEDD4/KLF15 axis. Journal of cachexia, sarcopenia and muscle 22 33687156
2016 Expanding the Spectrum of Renal Tumors in Children: Primary Renal Myoepithelial Carcinomas With a Novel EWSR1-KLF15 Fusion. The American journal of surgical pathology 22 26523541
2021 MiR-181a promotes cell proliferation and migration through targeting KLF15 in papillary thyroid cancer. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 21 34312797
2020 LncRNA LUCAT1/miR-181a-5p axis promotes proliferation and invasion of breast cancer via targeting KLF6 and KLF15. BMC molecular and cell biology 21 32998707
2022 KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation. Science advances 20 35263131
2022 Adrenergic receptor signaling induced by Klf15, a regulator of regeneration enhancer, promotes kidney reconstruction. Proceedings of the National Academy of Sciences of the United States of America 20 35939709
2022 Elabela blunts doxorubicin-induced oxidative stress and ferroptosis in rat aortic adventitial fibroblasts by activating the KLF15/GPX4 signaling. Cell stress & chaperones 20 36510036
2020 Dihydroartemisinin alleviates high glucose-induced vascular smooth muscle cells proliferation and inflammation by depressing the miR-376b-3p/KLF15 pathway. Biochemical and biophysical research communications 20 32753318
2019 KLF15 regulates endobiotic and xenobiotic metabolism. Nature metabolism 20 32694878
2005 Zinc-finger domains of the transcriptional repressor KLF15 bind multiple sites in rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements. BMC molecular biology 20 15963234
2017 Benzene and its metabolite decreases cell proliferation via LncRNA-OBFC2A-mediated anti-proliferation effect involving NOTCH1 and KLF15. Oncotarget 19 28388563
2022 Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle. The Journal of biological chemistry 18 35413288
2022 KLF15 suppresses tumor growth and metastasis in Triple-Negative Breast Cancer by downregulating CCL2 and CCL7. Scientific reports 18 36347994
2019 MiR-137-3p exacerbates the ischemia-reperfusion injured cardiomyocyte apoptosis by targeting KLF15. Naunyn-Schmiedeberg's archives of pharmacology 18 31822940
2018 Malignant Ewing-Like Neoplasm With an EWSR1-KLF15 Fusion: At the Crossroads of a Myoepithelial Carcinoma and a Ewing-Like Sarcoma. A Case Report With Treatment Options. International journal of surgical pathology 18 29390927
2017 KLF15 protects against isoproterenol-induced cardiac hypertrophy via regulation of cell death and inhibition of Akt/mTOR signaling. Biochemical and biophysical research communications 18 28336438
2017 KLF15 regulates in vitro chondrogenic differentiation of human mesenchymal stem cells by targeting SOX9. Biochemical and biophysical research communications 18 28923246
2017 Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPKα Signaling in Male Offspring of Obese Dams. Endocrinology 18 28938412
2021 Schisandrae chinensis Fructus Extract Ameliorates Muscle Atrophy in Streptozotocin-Induced Diabetic Mice by Downregulation of the CREB-KLF15 and Autophagy-Lysosomal Pathways. Cells 16 34571935
2020 Bta-miR-376a Targeting KLF15 Interferes with Adipogenesis Signaling Pathway to Promote Differentiation of Qinchuan Beef Cattle Preadipocytes. Animals : an open access journal from MDPI 16 33321855
2018 Loss of KLF15 accelerates chronic podocyte injury. International journal of molecular medicine 16 29901095
2017 Resveratrol-Mediated Expression of KLF15 in the Ischemic Myocardium is Associated with an Improved Cardiac Phenotype. Cardiovascular drugs and therapy 15 28064408
2010 Sp1 and KLF15 regulate basal transcription of the human LRP5 gene. BMC genetics 15 20141633
2023 The transcriptional regulator KLF15 is necessary for myoblast differentiation and muscle regeneration by activating FKBP5. The Journal of biological chemistry 14 37673339
2022 Integrative analysis of miRNA and mRNA profiles reveals that gga-miR-106-5p inhibits adipogenesis by targeting the KLF15 gene in chickens. Journal of animal science and biotechnology 14 35791010
2020 MiR-376b-3p functions as a tumor suppressor by targeting KLF15 in non-small cell lung cancer. European review for medical and pharmacological sciences 14 33015790
2016 Correlation of A2bAR and KLF4/KLF15 with Obesity-Dyslipidemia Induced Inflammation in Uygur Population. Mediators of inflammation 14 27199507
2014 A novel 2-bp indel within Krüppel-like factor 15 gene (KLF15) and its associations with chicken growth and carcass traits. British poultry science 14 25056727
2021 Myoepithelial Carcinoma of Soft Tissue With an EWSR1-KLF15 Gene Fusion in an Infant. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 13 33734915
2018 KLF15 Regulates the Expression of MMP-3 in Human Chondrocytes. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 13 30036111
2022 CTRP12 alleviates cardiomyocyte ischemia‑reperfusion injury via regulation of KLF15. Molecular medicine reports 12 35656890
2021 Inhibition of miR-431-5p attenuated liver apoptosis through KLF15/p53 signal pathway in S100 induced autoimmune hepatitis mice. Life sciences 12 34111466
2020 Teneligliptin Promotes Bile Acid Synthesis and Attenuates Lipid Accumulation in Obese Mice by Targeting the KLF15-Fgf15 Pathway. Chemical research in toxicology 12 32639145
2020 MiR-125a-3p-KLF15-BCAA Regulates the Skeletal Muscle Branched-Chain Amino Acid Metabolism in Nile Tilapia (Oreochromis niloticus) During Starvation. Frontiers in genetics 12 32849831
2020 KLF15 reduces the level of apoptosis in mouse liver induced by sepsis by inhibiting p38MAPK/ERK1/2 signaling pathway. European review for medical and pharmacological sciences 12 33155243
2017 Estrogen receptor beta maintains expression of KLF15 to prevent cardiac myocyte hypertrophy in female rodents. Molecular and cellular endocrinology 12 29127073
2017 Targeting and silencing of rhodopsin by ectopic expression of the transcription factor KLF15. JCI insight 12 29263295
2023 Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A. Translational oncology 11 36774884
2023 Hypoxic tumor cell-derived small extracellular vesicle miR-152-3p promotes cervical cancer radioresistance through KLF15 protein. Radiation oncology (London, England) 11 37936130
2014 KLF15 regulates slow myosin heavy chain expression through NFATc1 in C2C12 myotubes. Biochemical and biophysical research communications 11 24680826
2023 Macrophage KLF15 prevents foam cell formation and atherosclerosis via transcriptional suppression of OLR-1. Journal of molecular and cellular cardiology 10 37984156
2022 KLF15 controls brown adipose tissue transcriptional flexibility and metabolism in response to various energetic demands. iScience 10 36304102
2021 KLF15 Loss-of-Function Mutation Underlying Atrial Fibrillation as well as Ventricular Arrhythmias and Cardiomyopathy. Genes 10 33809104
2020 Transcriptome analysis of Klf15‑mediated inhibitory functions in a mouse deep venous thrombosis model. International journal of molecular medicine 10 32186780
2017 KLF15 regulates dopamine D2 receptor and participates in mouse models of neuropathic pain. Biochemical and biophysical research communications 10 28830816
2008 The Krüppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes. Biochemical and biophysical research communications 10 19094967
2024 Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in endometriosis. The Journal of endocrinology 9 38513352
2021 KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice. Toxicology and applied pharmacology 9 34310909
2020 MiR-376a-3p alleviates the development of glioma through negatively regulating KLF15. European review for medical and pharmacological sciences 9 33275234
2021 FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin. iScience 8 34988390