Affinage

KLF15

Krueppel-like factor 15 · UniProt Q9UIH9

Length
416 aa
Mass
44.0 kDa
Annotated
2026-06-10
100 papers in source corpus 47 papers cited in narrative 47 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KLF15 is a zinc-finger transcription factor that binds GC-rich consensus elements through its C-terminal zinc fingers to direct context-specific gene programs governing metabolism, circadian physiology, and tissue differentiation (PMID:15963234, PMID:35263131). Its zinc fingers recognize a 9 bp core element in a zinc-dependent, sequence-specific manner, and genome-wide cistrome mapping in liver shows KLF15 occupancy is predominantly promoter-enriched and largely activating (PMID:15963234, PMID:35263131). KLF15 functions combinatorially: it synergizes with partner factors at shared promoters—MEF2A at GLUT4, Sp1 at AceCS2, and C/EBPα at PPARγ2—to drive glucose uptake, mitochondrial acetyl-CoA metabolism, and adipogenesis (PMID:12097321, PMID:14960588, PMID:15664998). In the fasting liver it forms a complex with LXR/RXR on the Srebf1 promoter, switching the corepressor RIP140 for the coactivator SRC1 to repress lipogenesis, and it coordinates gluconeogenic and amino-acid-degrading enzymes together with PGC-1α to control hepatic glucose and nitrogen homeostasis (PMID:27545894, PMID:20393151, PMID:22405069). KLF15 also acts as a nodal output of the circadian clock, governing rhythmic nitrogen detoxification and biphasic cardiac transcriptomic oscillation (PMID:22405069, PMID:26686628). Across tissues it drives differentiation programs by activating lineage genes—nephrin/podocin in podocytes, SOX9 in chondrocytes, and FKBP5 in regenerating muscle (PMID:22493483, PMID:28923246, PMID:37673339)—and can repress targets by displacing coactivators, as in its block of P/CAF recruitment to the CTGF promoter (PMID:18586263). KLF15 abundance and localization are tightly regulated post-translationally: WWP1- and NEDD4-mediated K48-linked ubiquitination drives proteasomal degradation, SIRT3 deacetylates it, and SENP1-mediated deSUMOylation triggers nuclear export (PMID:30830866, PMID:36593958, PMID:33687156, PMID:28465484, PMID:29472234). Upstream, hepatic KLF15 is induced during fasting by the glucocorticoid receptor and FoxO1/3 and is embedded in the BMAL1/Per3 clock circuit (PMID:37702262, PMID:34988390, PMID:29186676). A KLF15 loss-of-function mutation (p.Lys229*) that abolishes its transcriptional activities is causally linked to atrial fibrillation and cardiomyopathy (PMID:33809104).

Mechanistic history

Synthesis pass · year-by-year structured walk · 20 steps
  1. 2002 High

    Established KLF15 as a functional transcription factor with a metabolic output by showing it directly activates GLUT4 and increases glucose uptake, framing it as a regulator of cellular glucose handling.

    Evidence Promoter mutagenesis, reporter assays, co-IP with MEF2A, and glucose uptake assays in adipocyte/muscle lines

    PMID:12097321

    Open questions at the time
    • Did not define the genome-wide target repertoire
    • Mechanism of MEF2A synergy not structurally resolved
  2. 2004 High

    Extended KLF15's metabolic reach and defined its combinatorial logic by showing cooperative activation with Sp1 at the AceCS2 promoter via adjacent GC-boxes.

    Evidence GST pull-down, promoter deletion/mutation, reporter assays in SL2 cells

    PMID:14960588

    Open questions at the time
    • In vivo relevance to acetyl-CoA metabolism untested in this study
  3. 2005 High

    Defined the biochemical basis of DNA recognition (zinc-dependent binding of a 9 bp core element) and showed KLF15 can repress as well as activate, broadening its functional range.

    Evidence EMSA, DNaseI footprinting with KLF15-GST, reporter assays on rhodopsin/IRBP promoters

    PMID:15963234

    Open questions at the time
    • Repression mechanism on these promoters not mapped to a corepressor
  4. 2005 High

    Placed KLF15 upstream in the adipogenic hierarchy by showing it is required for PPARγ2 induction and cooperates with C/EBPα, establishing an essential differentiation role.

    Evidence Dominant-negative, RNAi, overexpression, reporter assays, microarray in 3T3/C2C12

    PMID:15664998

    Open questions at the time
    • Direct binding to PPARγ2 promoter not shown by ChIP in this study
  5. 2008 High

    Revealed a coactivator-displacement mechanism of repression by showing KLF15 blocks P/CAF recruitment to the CTGF promoter, linking it to cardiac fibrosis suppression.

    Evidence Adenoviral overexpression, ChIP, EMSA, aortic banding in KLF15-/- mice

    PMID:18586263

    Open questions at the time
    • Whether displacement is direct competition or allosteric not resolved
  6. 2010 High

    Defined a central role in hepatic gluconeogenesis and amino-acid catabolism via PGC-1α coordination, and identified KLF15 protein instability as a node targeted by metformin.

    Evidence Liver-specific KO mice, adenoviral rescue, hepatocyte glucose production assays

    PMID:20393151

    Open questions at the time
    • Molecular basis of metformin-driven KLF15 degradation not identified
  7. 2012 High

    Established KLF15 as a circadian metabolic regulator by linking it to rhythmic nitrogen-to-urea detoxification under feeding control.

    Evidence Klf15-/- mice, metabolic and circadian profiling, feeding manipulation

    PMID:22405069

    Open questions at the time
    • Direct clock-factor inputs to Klf15 not yet defined at this stage
  8. 2012 High

    Demonstrated a developmental/differentiation role and an anti-hypertrophic cardiac function via direct promoter binding (nephrin/podocin) and repression of MRTF activity.

    Evidence ChIP, KLF15-/- podocyte injury models, co-IP with MRTF-A/B, rAAV cardiac overexpression

    PMID:22493483 PMID:22586493

    Open questions at the time
    • MRTF interaction surface not mapped beyond NLS localization
  9. 2013 High

    Connected KLF15 to nutrient/insulin signaling by showing its deficiency protects from hepatic insulin resistance and alters mTORC1/AMPK/autophagy via amino acid signaling.

    Evidence KLF15-/- mice, high-fat diet, ER stress induction, primary hepatocyte signaling analysis

    PMID:24167585

    Open questions at the time
    • Direct transcriptional targets bridging KLF15 to mTORC1 not enumerated
  10. 2016 High

    Defined a fasting-specific lipogenic-repression mechanism: KLF15 assembles with LXR/RXR on Srebf1 and recruits RIP140 over SRC1, switching the promoter to a repressed state.

    Evidence ChIP, reporter assays, complex analysis, mouse overexpression

    PMID:27545894

    Open questions at the time
    • Stoichiometry and direct binding partner within the LXR/RXR complex not resolved
  11. 2016 High

    Established KLF15 as a circadian output node in the heart governing biphasic active/resting transcriptomic oscillation independent of the core clock.

    Evidence Cardiomyocyte-specific KLF15 depletion, transcriptome and circadian profiling

    PMID:26686628

    Open questions at the time
    • Direct cardiac target genes driving phase partition not individually validated
  12. 2018 High

    Showed KLF15 localization is dynamically controlled by SUMOylation: hypoxia-driven SENP1 deSUMOylation exports KLF15 from the nucleus, de-repressing Arg2 and altering vascular tone.

    Evidence ChIP, subcellular fractionation, SENP1 modulation, isolated artery functional assay

    PMID:29472234

    Open questions at the time
    • SUMO acceptor site on KLF15 not mapped in this entry
  13. 2019 High

    Identified WWP1/NEDD4-mediated K48-linked ubiquitination as the dominant control over KLF15 protein levels, linking its stability to muscle atrophy and cardiac inflammation.

    Evidence Muscle- and heart-specific KO mice, WWP1/NEDD4 modulation, K48 ubiquitination co-IP, MI and dexamethasone models

    PMID:30830866 PMID:33687156 PMID:36593958

    Open questions at the time
    • Ubiquitin acceptor lysines on KLF15 not defined
    • Hierarchy between WWP1 and NEDD4 across tissues unresolved
  14. 2019 High

    Established KLF15 as a master transcriptional controller of all three phases of hepatic endobiotic/xenobiotic metabolism, governing drug, bile acid, and steroid handling.

    Evidence Liver-specific KO, transcriptomics, viral reconstitution, hormone and toxicity assays

    PMID:32694878

    Open questions at the time
    • Cofactor requirements for phase I–III gene activation not dissected
  15. 2021 Medium

    Linked KLF15 to human disease by demonstrating a loss-of-function truncation (p.Lys229*) abolishes both its activating and repressive transcriptional activities, causing atrial fibrillation and cardiomyopathy.

    Evidence Whole exome sequencing, pedigree analysis, dual-luciferase assays of mutant KLF15 on KChIP2 and CTGF

    PMID:33809104

    Open questions at the time
    • Single family/lab functional validation
    • Structural consequence of truncation on zinc fingers not modeled
  16. 2021 High

    Defined a mechanosensory atrophy pathway in which immobilization lowers cytosolic Ca2+ via Piezo1, inducing KLF15 and IL-6 to drive muscle wasting.

    Evidence Ca2+ bioimaging, Piezo1 disruption, muscle-specific KLF15 and IL-6 KO mice, human validation

    PMID:35290243

    Open questions at the time
    • Direct transcriptional link from KLF15 to Il6 not defined at promoter level
  17. 2022 High

    Provided genome-wide definition of KLF15 occupancy and a physical PPARδ partnership, plus a direct CBG/corticosteroid-transport program, refining its mechanism as a promoter-enriched activator.

    Evidence ChIP-seq cistromes in Klf15-3xFLAG mice, ATAC-seq, co-IP with PPARδ, KO and reconstitution

    PMID:35263131 PMID:35413288

    Open questions at the time
    • Determinants of tissue-specific promoter vs distal-enhancer occupancy not resolved
  18. 2023 High

    Mapped the upstream fasting circuit by showing glucocorticoid receptor and FoxO1/3 directly bind the KLF15 enhancer/promoter, placing KLF15 downstream of the insulin/glucocorticoid axis to switch macronutrient flow.

    Evidence GR and FoxO ChIP/binding analysis, KLF15-KO epistasis, fasting experiments

    PMID:34988390 PMID:37702262

    Open questions at the time
    • Relative contribution of GR vs FoxO inputs in different fasting states not quantified
  19. 2023 High

    Demonstrated a regenerative differentiation role in muscle by showing KLF15 directly activates FKBP5 to enable myoblast fusion and repair, with FKBP5 delivery rescuing the KO.

    Evidence ChIP, KLF15-KO muscle injury model, transcriptomics, FKBP5 rescue

    PMID:37673339

    Open questions at the time
    • Mechanism by which FKBP5 promotes fusion downstream of KLF15 not detailed
  20. 2024 Medium

    Extended KLF15's gene-regulatory roles to reproduction and cancer suppression through direct activation of TWIST2 and LINC00689 programs.

    Evidence ChIP-qPCR, RNA-seq, in vivo implantation and tumor proliferation assays

    PMID:38273088 PMID:38513352

    Open questions at the time
    • Single-lab findings
    • Tissue-specific selection of these targets versus metabolic targets unexplained

Open questions

Synthesis pass · forward-looking unresolved questions
  • How KLF15 selects activating versus repressive modes and tissue-specific target sets across its diverse programs remains unresolved.
  • No unifying model linking partner choice (Sp1, C/EBPα, LXR/RXR, PPARδ) to activate/repress decision
  • Ubiquitin/SUMO/acetyl acceptor residues largely unmapped
  • Structural basis of zinc-finger–promoter recognition not solved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 7 GO:0003677 DNA binding 4 GO:0098772 molecular function regulator activity 3
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 1
Pathway
R-HSA-1430728 Metabolism 5 R-HSA-1266738 Developmental Biology 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-392499 Metabolism of proteins 3 R-HSA-9909396 Circadian clock 3
Partners
CEBPAMEF2AMRTF-ANEDD4PPARDSIRT3SP1WWP1
Complex memberships
KLF15-LXR/RXR-RIP140 corepressor complex on Srebf1 promoter

Evidence

Reading pass · 47 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 KLF15 directly activates GLUT4 expression in adipose and muscle cell lines, requiring an intact KLF15-binding site proximal to the MEF2A site in the GLUT4 promoter; KLF15 physically interacts with MEF2A (co-immunoprecipitation) and synergistically activates the GLUT4 promoter with MEF2A; KLF15 overexpression increases both basal and insulin-stimulated glucose uptake in adipocytes. Co-transfection/reporter assays, promoter deletion and mutational analyses, co-immunoprecipitation, glucose uptake assays The Journal of biological chemistry High 12097321
2004 KLF15 transcriptionally activates the mitochondrial acetyl-CoA synthetase gene AceCS2 through the most proximal KLF-binding site in its promoter; KLF15 physically interacts with Sp1 (GST pull-down) and synergistically activates the AceCS2 promoter with Sp1 through an adjacent GC-box. Luciferase reporter assays, promoter deletion/mutation analyses, GST pull-down, Drosophila SL2 cell transfection, quantitative RT-PCR The Journal of biological chemistry High 14960588
2005 KLF15 plays an essential role in adipogenesis by transcriptionally upregulating PPARγ2; KLF15 and C/EBPα synergistically activate the PPARγ2 promoter; dominant-negative KLF15 or RNAi reduces PPARγ expression and blocks adipogenesis without affecting C/EBPβ induction; C/EBPα, C/EBPβ, and C/EBPδ can induce KLF15 expression. Dominant-negative overexpression, RNA interference, ectopic overexpression in NIH 3T3/C2C12 cells, luciferase reporter assay, microarray The Journal of biological chemistry High 15664998
2005 KLF15 zinc-finger domains bind a 9 bp consensus sequence (core CG/TCCCC) in a zinc-dependent, sequence-specific manner; KLF15 binds multiple sites in the rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements, and represses promoter activation by CRX and/or NRL. EMSA, DNaseI footprinting with KLF15-GST fusion protein, luciferase reporter assay BMC molecular biology High 15963234
2008 KLF15 inhibits CTGF expression in cardiac fibroblasts by blocking recruitment of the co-activator P/CAF to the CTGF promoter without affecting Smad3-DNA binding; KLF15 overexpression suppresses basal and TGFβ1-induced CTGF promoter activity; KLF15-/- mice subjected to aortic banding show increased CTGF and fibrosis. Adenoviral overexpression, luciferase reporter assay, ChIP, EMSA, aortic banding mouse model Journal of molecular and cellular cardiology High 18586263
2009 KLF15 directly binds the HSD17B5 (17β-HSD5) promoter and transcriptionally activates it, increasing testosterone formation; a KLF15 binding site was identified by luciferase reporter constructs, EMSA, and ChIP; insulin increases KLF15 mRNA and HSD17B5 promoter activity. Luciferase reporter assay, EMSA, chromatin immunoprecipitation (ChIP), RT-PCR The Journal of clinical endocrinology and metabolism High 19366843
2009 miR-133 targets the 3'UTR of KLF15 and reduces its protein level, thereby decreasing GLUT4 expression and insulin-mediated glucose uptake in cardiomyocytes. Forced expression of miR-133, lenti-decoy reporter, western blot, glucose uptake assay Biochemical and biophysical research communications Medium 19720047
2010 KLF15 regulates hepatic gluconeogenesis by coordinating expression of gluconeogenic and amino acid-degrading enzyme genes with the coactivator PGC-1α; liver-specific KLF15 ablation in diabetic mice reduces gluconeogenic gene expression and ameliorates hyperglycemia; metformin reduces KLF15 abundance by accelerating its degradation and reducing its mRNA, and its suppression of gluconeogenesis is attenuated by restoration of KLF15. Liver-specific KO mice, adenoviral KLF15 restoration, cultured hepatocytes, glucose production assay, gene expression analysis Diabetes High 20393151
2010 KLF15 directly activates transcription of the UCP1 promoter through GT-box elements in brown adipocytes; KLF15 and KLF11 both interact directly with the UCP1 promoter. Promoter reporter assay, co-transfection in mesenchymal stem cell line, promoter binding analysis Biochemical and biophysical research communications Medium 20709022
2010 KLF15 and Sp1 cooperatively activate the human LRP5 promoter through adjacent binding sites in the -72 to -53 bp region; ChIP confirms KLF15 and Sp1 binding to this region in cells; Drosophila SL2 cell transactivation is dependent on intact Sp1 and KLF15 binding motifs. Luciferase reporter assay, ChIP, Drosophila SL2 cell transfection, mutational analysis BMC genetics Medium 20141633
2012 KLF15 is required for podocyte differentiation; KLF15 binds to promoter regions of nephrin and podocin (ChIP); KLF15-/- mice show increased susceptibility to podocyte injury; overexpression of KLF15 stimulates expression of differentiation markers. ChIP, KLF15-/- mice with LPS/adriamycin challenge, adenoviral overexpression, reporter assay, microarray The Journal of biological chemistry High 22493483
2012 KLF15 inhibits estrogen-induced uterine epithelial cell proliferation by binding the Mcm2 promoter under progesterone regulation, recruiting HDAC1/3, increasing H3 methylation and decreasing H3 acetylation, and inhibiting RNA polymerase II binding; KLF15 ectopic expression in an estrogenized uterus mimics progesterone's inhibition of MCM2 and DNA synthesis. ChIP, transient transfection, in vivo uterine injection, cell proliferation assay, histone modification analysis Proceedings of the National Academy of Sciences of the United States of America High 22538816
2012 KLF15 interacts with and strongly represses the transcriptional activity of myocardin-related transcription factors MRTF-A and MRTF-B; the nuclear localization signal of KLF15 was mapped to a region within its C-terminal zinc fingers; cardiac overexpression of KLF15 via rAAV prevents angiotensin II-induced cardiac hypertrophy. Co-immunoprecipitation/interaction assay, reporter assay, rAAV cardiac overexpression, mouse model of angiotensin II-induced hypertrophy PloS one Medium 22586493
2012 KLF15 deficiency disrupts circadian amino acid rhythms and impairs rhythmic ammonia-to-urea detoxification; Klf15 transcriptionally coordinates rhythmic expression of multiple enzymes involved in nitrogen homeostasis; feeding plays a dominant role in modulating KLF15 rhythm. Klf15-/- mice, metabolic profiling, circadian rhythm analysis, feeding manipulation Cell metabolism High 22405069
2013 KLF15 is an essential mediator of ER stress-induced insulin resistance in the liver; KLF15-/- mice are protected from hepatic insulin resistance under high-fat feeding; KLF15 deficiency is associated with decreased mTORC1 activity, increased AMPK phosphorylation, and activation of autophagy; KLF15 controls mTORC1-mediated insulin resistance via amino acid signaling in primary hepatocytes. KLF15-/- mice, high-fat diet, pharmacological ER stress induction, primary hepatocyte assays, mTORC1/AMPK signaling analysis PloS one High 24167585
2014 KLF15 regulates slow myosin heavy chain (MHC-β/slow) expression in muscle by binding the NFATc1 promoter and inducing its activity, thereby mediating calcineurin/NFAT signaling; this was shown by gene silencing, overexpression, and luciferase reporter assay in C2C12 myotubes. Gene silencing (siRNA), overexpression, luciferase reporter assay, gene expression analysis in C2C12 myotubes Biochemical and biophysical research communications Medium 24680826
2015 KLF15 is the first identified negative regulator of circadian ileal Fgf15 expression; using biochemical, molecular, and functional assays (including ileectomy and bile duct catheterization), liver-specific KLF15-KO studies showed a non-hepatic basis for bile acid regulation, and KLF15 controls circadian bile acid production through regulation of Fgf15. Systemic and liver-specific Klf15-KO mice, bile acid/lipid absorption measurement, ileectomy, bile duct catheterization, molecular assays Nature communications High 26040986
2015 KLF15 governs biphasic transcriptomic oscillation in the heart corresponding to active (ATP production) and resting (remodeling/repair) phases; cardiomyocyte-specific depletion of KLF15 leads to disorganized oscillatory behavior without phasic partition despite an intact core clock, establishing KLF15 as a nodal connection between the circadian clock and cardiac rhythmicity. Cardiomyocyte-specific KLF15 depletion, transcriptome profiling, circadian rhythm analysis Cell reports High 26686628
2016 During fasting, KLF15 forms a complex with LXR/RXR specifically on the Srebf1 promoter, recruiting the corepressor RIP140 instead of the coactivator SRC1, thereby repressing SREBP-1c and downstream lipogenic enzyme expression; KLF15 overexpression specifically ameliorates hypertriglyceridemia. ChIP, promoter reporter assay, protein complex analysis (co-immunoprecipitation implied), mouse overexpression model Cell reports High 27545894
2016 KLF15 binds to the ACSL1 promoter region and drives its transcription in bovine adipocytes; this was confirmed by mutational analysis and EMSA; E2F1, Sp1, E2F4, and KLF15 all bind the ACSL1 promoter proximal region. Luciferase reporter assay, EMSA, ChIP (implied), mutational analysis Scientific reports Medium 26782942
2017 Per3 and BMAL1 directly regulate Klf15 expression in adipocyte precursor cells; deletion of Per3 promotes adipogenesis in vivo through this clock output pathway acting via KLF15. Per3 deletion mice, in vivo adipogenesis analysis, chromatin analysis of BMAL1/Per3 binding at Klf15 promoter Cell reports Medium 29186676
2017 c-Jun directly binds near glucocorticoid response element (GRE) sites in the KLF15 promoter and inhibits glucocorticoid receptor (GR)-induced KLF15 promoter activity, thereby suppressing adipocyte differentiation; restoration of KLF15 expression partially rescues adipogenesis blocked by c-Jun. ChIP, luciferase reporter assay, stable ectopic expression, adipocyte differentiation rescue assay Biochemical and biophysical research communications Medium 26692489
2017 SIRT3 co-localizes with KLF15 and directly deacetylates KLF15 in podocytes, resulting in decreased expression of fibronectin and collagen type IV; SIRT3 overexpression attenuates angiotensin II-induced kidney fibrosis through this KLF15-mediated mechanism. Co-localization (immunofluorescence), deacetylation assay, co-IP, SIRT3 KO/overexpression mice, cultured podocytes Oncotarget Medium 28465484
2017 KLF15 directly activates the Twist2 promoter by binding it (confirmed by ChIP); KLF15-induced Twist2 expression ameliorates hepatic steatosis via NF-κB-FGF21 or SREBP1c-FGF21 pathways. ChIP, luciferase reporter assay, KLF15 overexpression in hepatocytes FASEB journal Medium 31648561
2017 KLF15 directly binds the promoter of Drd2 (dopamine D2 receptor) and promotes its promoter activity; KLF15 is induced in neurons by TNF-α; knockout of Klf15 reduces neuropathic pain sensitivity induced by CCI or SNI. Promoter reporter assay, ChIP, Klf15 KO mice, neuropathic pain models (CCI, SNI) Biochemical and biophysical research communications Medium 28830816
2017 KLF15 directly regulates chondrogenic differentiation of human MSCs by binding the SOX9 promoter and activating SOX9 expression; KLF15 knockdown represses chondrogenic differentiation while KLF15 overexpression facilitates it. Lentivirus-mediated knockdown, overexpression, luciferase reporter assay, promoter binding analysis (ChIP) Biochemical and biophysical research communications Medium 28923246
2018 KLF15 directly binds to the core promoter region of bovine KLF3 gene, confirmed by EMSA and ChIP; KLF15 overexpression increases KLF3 expression and KLF15 knockdown reduces it in bovine adipocytes. Adenoviral overexpression, siRNA knockdown, luciferase reporter assay with deletion constructs, EMSA, ChIP Gene Medium 29551501
2018 Hypoxia triggers deSUMOylation of KLF15 by SENP1, causing translocation of KLF15 from nucleus to cytoplasm; nuclear KLF15 directly binds the Arg2 promoter (ChIP) and represses arginase 2 expression; KLF15 overexpression rescues nitric oxide production and reverses hypoxia-induced vasoconstriction. ChIP, fractionation/localization studies, SENP1 modulation, overexpression in HPMEC, isolated artery functional assay Arteriosclerosis, thrombosis, and vascular biology High 29472234
2018 KLF15 directly binds the promoter region of MMP-3 (ChIP assay) and reduces TNF-α-induced MMP-3 expression at the transcriptional level in human chondrocytes; TNF-α reduces KLF15 expression via p53. ChIP, overexpression, quantitative gene expression, cell stimulation with TNF-α Journal of interferon & cytokine research Medium 30036111
2019 Hyperglycemia upregulates KLF15 protein in skeletal muscle by downregulating the E3 ubiquitin ligase WWP1, leading to suppression of ubiquitin-dependent degradation of KLF15; muscle-specific KLF15 deficiency protects from diabetes-induced decline of skeletal muscle mass. Diabetic mouse models, muscle-specific KO mice, WWP1 modulation, ubiquitination assay, protein stability analysis JCI insight High 30830866
2019 WWP1 targets KLF15 for K48-linked polyubiquitination and proteasomal degradation in cardiomyocytes; WWP1-mediated KLF15 degradation contributes to upregulation of p65 acetylation and activation of MAPK inflammatory signaling after myocardial infarction. rAAV9-mediated overexpression, adenovirus system, ubiquitination assay (K48-linked), co-IP, MI mouse model Theranostics High 36593958
2019 KLF15 regulates all three phases (I–III) of the endobiotic and xenobiotic metabolism (EXM) system in the liver by direct transcriptional control; liver-specific KLF15 deficiency alters expression of phase I–III targets, renders animals resistant to bile acid and acetaminophen toxicity, and enhances degradation of endogenous steroids (testosterone, glucocorticoid); viral reconstitution reverses these phenotypes. Liver-specific KO mice, unbiased transcriptomics, viral reconstitution, hormone measurement, toxicity assays Nature metabolism High 32694878
2020 HDAC11 interacts with AP-2α and represses KLF15 transcription; HDAC11 inhibition or depletion relieves KLF15 repression and blocks pro-fibrogenic responses in renal tubular epithelial cells; KLF15 knockdown antagonizes the anti-fibrotic effect of HDAC11 inhibition. Co-IP, siRNA knockdown, qPCR, pharmaceutical inhibition (quisinostat), mouse UUO model Frontiers in cell and developmental biology Medium 32363192
2021 Immobilization reduces cytosolic Ca2+ concentration in skeletal muscle via downregulation of Piezo1, which induces KLF15 and subsequently IL-6 expression leading to muscle atrophy; Piezo1 disruption induces Klf15 and Il6, and KLF15 muscle-specific deficiency or IL-6 deficiency protects from immobility-induced atrophy. Ca2+ bioimaging, Piezo1 acute disruption, muscle-specific KLF15 KO mice, IL-6 KO mice, antibody blockade, human sample validation The Journal of clinical investigation High 35290243
2021 FoxO1/3 transcriptionally regulates Klf15 gene expression by directly binding to the liver-specific Klf15 promoter; attenuation of insulin signaling increases hepatic KLF15 via FoxOs, which then elevates amino acid catabolic enzyme expression and suppresses SREBP-1c; this FoxO-KLF15 pathway switches macronutrient flow during fasting. TFEL scan genome-wide transcription factor screening, in vivo promoter analysis, KLF15-KO mice, ChIP-like binding validation iScience High 34988390
2022 KLF15 directly binds the Serpina6 promoter at a palindromic GC-rich motif, opens chromatin, and transactivates Serpina6 (encoding CBG); Klf15-deficient mice have profoundly reduced CBG and impaired plasma corticosteroid transport; KLF15 cistromes (generated via newly engineered Klf153xFLAG mice) show liver KLF15 is predominantly promoter-enriched with minimal direct gene repression activity. KLF15 cistrome (ChIP-seq in Klf153xFLAG mice), Klf15-KO mice, CBG reconstitution, ATAC-seq, reporter assays Science advances High 35263131
2022 KLF15 and PPARδ physically interact (co-localization, co-IP), colocalize genome-wide in skeletal muscle (ChIP-seq), and are mutually dependent for their transcriptional effects on lipid metabolic target genes; KLF15 cistrome in skeletal muscle is enriched at distal intergenic regions associated with circadian rhythmicity and lipid metabolism genes. ChIP-seq (KLF15 and PPARδ cistromes), Co-IP/physical interaction assay, KLF15 KO in skeletal muscle, gene expression analysis The Journal of biological chemistry High 35413288
2022 KLF15 plays a critical role in brown adipose tissue (BAT) metabolic flexibility; BAT-specific loss of KLF15 results in widespread changes in circulating metabolites and severely compromised thermogenesis under high energy demands, indicating impaired nutrient utilization. BAT-specific KLF15-KO mice, metabolomics, thermogenesis testing, transcriptomics iScience High 36304102
2022 Xenopus Klf15 directly binds regeneration enhancers and stimulates expression of regenerative genes including adrenoreceptor alpha 1A (adra1a) in regenerating nephric tubules; inhibition of Klf15 causes failure of nephric tubule regeneration; pharmacological inhibition of Adra1a-signaling suppresses tubule regeneration. ATAC-seq, H3K27ac ChIP-seq, Klf15 inhibition, Xenopus kidney regeneration model, pharmacological treatment Proceedings of the National Academy of Sciences of the United States of America Medium 35939709
2023 KLF15 directly binds the promoter region of FKBP5 and activates its expression; KLF15 deficiency impairs myoblast fusion and muscle regeneration after injury; local delivery of FKBP5 rescues impaired regeneration in Klf15-KO mice. ChIP, KLF15-KO mice, muscle injury model, transcriptome analysis, FKBP5 delivery rescue The Journal of biological chemistry High 37673339
2023 GR (glucocorticoid receptor) directly binds the KLF15 enhancer during fasting and regulates hepatic KLF15 expression; KLF15 is necessary for GR-mediated suppression of SREBP-1c during fasting, forming a GR-KLF15-SREBP-1c pathway controlling lipogenesis. KLF15-KO mice, ChIP (GR binding at KLF15 enhancer), gene expression analysis, fasting experiments The FEBS journal High 37702262
2023 Macrophage KLF15 directly binds the OLR-1 (lectin-like oxidized LDL receptor-1) promoter and transcriptionally downregulates OLR-1 expression; KLF15 overexpression prevents foam cell formation by reducing OLR-1-mediated lipid uptake; restoration of OLR-1 reverses KLF15's beneficial effects on atherosclerosis. ChIP, promoter reporter assay, AAV overexpression in atherosclerosis mouse models, lipid uptake assay Journal of molecular and cellular cardiology Medium 37984156
2021 KLF15 loss-of-function mutation (p.Lys229*) abrogates both transcriptional activation of the KChIP2 promoter and transcriptional inhibition of the CTGF promoter (with or without TGFB1), establishing KLF15 as causally linked to atrial fibrillation and cardiomyopathy via loss of these transcriptional activities. Whole exome sequencing, dual-luciferase assay with mutant KLF15, Sanger sequencing, pedigree analysis Genes Medium 33809104
2017 KLF15 directly activates the glucocorticoid receptor (GR) by binding a GRE in the KLF15 promoter and is induced by glucocorticoids in human airway smooth muscle (ASM); KLF15 represses ASM hypertrophy and PLCD1 was identified as a direct KLF15-regulated target gene by integrating transcriptome data with ChIP-seq of RNA Pol II and GR occupancy. GR ChIP-seq, RNA Pol II ChIP-seq, KLF15 overexpression transcriptome, primary human ASM cells American journal of respiratory cell and molecular biology High 28375666
2024 KLF15 transcriptionally activates LINC00689 expression; KLF15/LINC00689 axis suppresses colorectal cancer cell proliferation and metastasis; downstream, LINC00689 recruits PTBP1 to stabilize LATS2 mRNA, suppressing the YAP1/β-catenin pathway. ChIP, reporter assay, RNA-seq, co-IP (PTBP1-LINC00689), in vitro/in vivo cell proliferation assays Communications biology Medium 38273088
2024 Progesterone receptor (PR) directly binds to KLF15 promoter regions (ChIP-qPCR) in uterine epithelial cells; KLF15 in turn directly binds the TWIST2 promoter (ChIP-qPCR) and promotes epithelial-mesenchymal transition; KLF15 loss impairs endometrial receptivity and reduces embryo implantation in vivo. ChIP-qPCR, siRNA knockdown, KLF15 overexpression, RNA-seq, in vivo rat uterine injection, embryo implantation assay The Journal of endocrinology Medium 38513352
2021 The E3 ubiquitin ligase NEDD4 ubiquitinates KLF15 in skeletal muscle; obestatin signaling counteracts glucocorticoid-induced KLF15 ubiquitination via NEDD4, thereby preventing KLF15-driven atrogene expression and muscle atrophy; FoxO4 phosphorylation by Akt cooperates with NEDD4 in regulating FoxO and KLF15. In vivo dexamethasone-induced atrophy model, ubiquitination assay, in vitro human myotube (KM155C25) studies Journal of cachexia, sarcopenia and muscle Medium 33687156

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Role of Krüppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. The Journal of biological chemistry 271 15664998
2002 The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. The Journal of biological chemistry 200 12097321
2019 Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis. JCI insight 164 30830866
2009 MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes. Biochemical and biophysical research communications 157 19720047
2012 Klf15 orchestrates circadian nitrogen homeostasis. Cell metabolism 117 22405069
2010 Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action. Diabetes 99 20393151
2012 Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation. The Journal of biological chemistry 93 22493483
2008 The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. Journal of molecular and cellular cardiology 87 18586263
2022 Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling. Free radical biology & medicine 79 36334846
2016 KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting. Cell reports 77 27545894
2015 Circadian control of bile acid synthesis by a KLF15-Fgf15 axis. Nature communications 76 26040986
2012 KLF15 negatively regulates estrogen-induced epithelial cell proliferation by inhibition of DNA replication licensing. Proceedings of the National Academy of Sciences of the United States of America 74 22538816
2004 A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2. The Journal of biological chemistry 74 14960588
2015 KLF15 Establishes the Landscape of Diurnal Expression in the Heart. Cell reports 73 26686628
2022 A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy. The Journal of clinical investigation 70 35290243
2017 The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15. Cell reports 69 29186676
2011 Low-protein diet supplemented with ketoacids reduces the severity of renal disease in 5/6 nephrectomized rats: a role for KLF15. Kidney international 61 21248717
2019 LncRNA TTN-AS1 sponges miR-376a-3p to promote colorectal cancer progression via upregulating KLF15. Life sciences 55 31610194
2020 Histone Deacetylase 11 Contributes to Renal Fibrosis by Repressing KLF15 Transcription. Frontiers in cell and developmental biology 54 32363192
2011 Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness. American journal of respiratory cell and molecular biology 53 21257922
2023 Targeting WWP1 ameliorates cardiac ischemic injury by suppressing KLF15-ubiquitination mediated myocardial inflammation. Theranostics 52 36593958
2018 Tanshinol alleviates impaired bone formation by inhibiting adipogenesis via KLF15/PPARγ2 signaling in GIO rats. Acta pharmacologica Sinica 48 29323335
2009 KLF15 Is a transcriptional regulator of the human 17beta-hydroxysteroid dehydrogenase type 5 gene. A potential link between regulation of testosterone production and fat stores in women. The Journal of clinical endocrinology and metabolism 45 19366843
2015 Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes. PloS one 44 26301956
2015 KLF15 in breast cancer: a novel tumor suppressor? Cellular oncology (Dordrecht, Netherlands) 42 25869021
2017 SIRT3-KLF15 signaling ameliorates kidney injury induced by hypertension. Oncotarget 41 28465484
2010 Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15. Biochemical and biophysical research communications 41 20709022
2018 Absence of miR-223-3p ameliorates hypoxia-induced injury through repressing cardiomyocyte apoptosis and oxidative stress by targeting KLF15. European journal of pharmacology 38 30336138
2021 Activation of PKG-CREB-KLF15 by melatonin attenuates Angiotensin II-induced vulnerability to atrial fibrillation via enhancing branched-chain amino acids catabolism. Free radical biology & medicine 37 34864165
2013 KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. PloS one 37 24167585
2018 Allicin induces beige-like adipocytes via KLF15 signal cascade. The Journal of nutritional biochemistry 36 30423518
2016 Characterization of the promoter region of the bovine long-chain acyl-CoA synthetase 1 gene: Roles of E2F1, Sp1, KLF15, and E2F4. Scientific reports 36 26782942
2012 Repression of cardiac hypertrophy by KLF15: underlying mechanisms and therapeutic implications. PloS one 36 22586493
2017 KLF15 Inhibits Cell Proliferation in Gastric Cancer Cells via Up-Regulating CDKN1A/p21 and CDKN1C/p57 Expression. Digestive diseases and sciences 35 28421457
2017 Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway. Frontiers in physiology 32 29118722
2019 Multiple roles of KLF15 in the heart: Underlying mechanisms and therapeutic implications. Journal of molecular and cellular cardiology 30 30831134
2017 Global transcriptome profiling identifies KLF15 and SLC25A10 as modifiers of adipocytes insulin sensitivity in obese women. PloS one 30 28570579
2018 KLF15 promotes transcription of KLF3 gene in bovine adipocytes. Gene 28 29551501
2015 c-Jun regulates adipocyte differentiation via the KLF15-mediated mode. Biochemical and biophysical research communications 28 26692489
2021 Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis. Biology direct 27 34727954
2019 KLF15-activating Twist2 ameliorated hepatic steatosis by inhibiting inflammation and improving mitochondrial dysfunction via NF-κB-FGF21 or SREBP1c-FGF21 pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26 31648561
2018 Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium. Arteriosclerosis, thrombosis, and vascular biology 26 29472234
2016 Tanshinol Rescues the Impaired Bone Formation Elicited by Glucocorticoid Involved in KLF15 Pathway. Oxidative medicine and cellular longevity 26 27051474
2020 Circular RNA MTO1 Inhibits the Proliferation and Invasion of Ovarian Cancer Cells Through the miR-182-5p/KLF15 Axis. Cell transplantation 25 32731816
2019 KLF15-Wnt-Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart. Journal of the American College of Cardiology 25 31582141
2017 Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy. American journal of respiratory cell and molecular biology 25 28375666
2021 Obestatin signalling counteracts glucocorticoid-induced skeletal muscle atrophy via NEDD4/KLF15 axis. Journal of cachexia, sarcopenia and muscle 24 33687156
2018 Protective effect of KLF15 on vascular endothelial dysfunction induced by TNF‑α. Molecular medicine reports 24 29956764
2016 miR-4262 Promotes Proliferation and Invasion of Human Breast Cancer Cells Through Directly Targeting KLF6 and KLF15. Oncology research 24 27629257
2015 KLF15 is an essential negative regulatory factor for the cardiac remodeling response to pressure overload. Cardiology 24 25633973
2015 KLF15 suppresses cell proliferation and extracellular matrix expression in mesangial cells under high glucose. International journal of clinical and experimental medicine 24 26884948
2020 LncRNA LUCAT1/miR-181a-5p axis promotes proliferation and invasion of breast cancer via targeting KLF6 and KLF15. BMC molecular and cell biology 22 32998707
2016 Expanding the Spectrum of Renal Tumors in Children: Primary Renal Myoepithelial Carcinomas With a Novel EWSR1-KLF15 Fusion. The American journal of surgical pathology 22 26523541
2022 KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation. Science advances 21 35263131
2021 MiR-181a promotes cell proliferation and migration through targeting KLF15 in papillary thyroid cancer. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 21 34312797
2020 Dihydroartemisinin alleviates high glucose-induced vascular smooth muscle cells proliferation and inflammation by depressing the miR-376b-3p/KLF15 pathway. Biochemical and biophysical research communications 21 32753318
2022 Adrenergic receptor signaling induced by Klf15, a regulator of regeneration enhancer, promotes kidney reconstruction. Proceedings of the National Academy of Sciences of the United States of America 20 35939709
2022 Elabela blunts doxorubicin-induced oxidative stress and ferroptosis in rat aortic adventitial fibroblasts by activating the KLF15/GPX4 signaling. Cell stress & chaperones 20 36510036
2019 KLF15 regulates endobiotic and xenobiotic metabolism. Nature metabolism 20 32694878
2005 Zinc-finger domains of the transcriptional repressor KLF15 bind multiple sites in rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements. BMC molecular biology 20 15963234
2022 Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle. The Journal of biological chemistry 19 35413288
2017 Benzene and its metabolite decreases cell proliferation via LncRNA-OBFC2A-mediated anti-proliferation effect involving NOTCH1 and KLF15. Oncotarget 19 28388563
2017 KLF15 regulates in vitro chondrogenic differentiation of human mesenchymal stem cells by targeting SOX9. Biochemical and biophysical research communications 19 28923246
2022 KLF15 suppresses tumor growth and metastasis in Triple-Negative Breast Cancer by downregulating CCL2 and CCL7. Scientific reports 18 36347994
2019 MiR-137-3p exacerbates the ischemia-reperfusion injured cardiomyocyte apoptosis by targeting KLF15. Naunyn-Schmiedeberg's archives of pharmacology 18 31822940
2018 Malignant Ewing-Like Neoplasm With an EWSR1-KLF15 Fusion: At the Crossroads of a Myoepithelial Carcinoma and a Ewing-Like Sarcoma. A Case Report With Treatment Options. International journal of surgical pathology 18 29390927
2017 KLF15 protects against isoproterenol-induced cardiac hypertrophy via regulation of cell death and inhibition of Akt/mTOR signaling. Biochemical and biophysical research communications 18 28336438
2017 Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPKα Signaling in Male Offspring of Obese Dams. Endocrinology 18 28938412
2021 Schisandrae chinensis Fructus Extract Ameliorates Muscle Atrophy in Streptozotocin-Induced Diabetic Mice by Downregulation of the CREB-KLF15 and Autophagy-Lysosomal Pathways. Cells 17 34571935
2020 Bta-miR-376a Targeting KLF15 Interferes with Adipogenesis Signaling Pathway to Promote Differentiation of Qinchuan Beef Cattle Preadipocytes. Animals : an open access journal from MDPI 16 33321855
2018 Loss of KLF15 accelerates chronic podocyte injury. International journal of molecular medicine 16 29901095
2023 The transcriptional regulator KLF15 is necessary for myoblast differentiation and muscle regeneration by activating FKBP5. The Journal of biological chemistry 15 37673339
2018 KLF15 Regulates the Expression of MMP-3 in Human Chondrocytes. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 15 30036111
2017 Resveratrol-Mediated Expression of KLF15 in the Ischemic Myocardium is Associated with an Improved Cardiac Phenotype. Cardiovascular drugs and therapy 15 28064408
2010 Sp1 and KLF15 regulate basal transcription of the human LRP5 gene. BMC genetics 15 20141633
2022 Integrative analysis of miRNA and mRNA profiles reveals that gga-miR-106-5p inhibits adipogenesis by targeting the KLF15 gene in chickens. Journal of animal science and biotechnology 14 35791010
2020 MiR-376b-3p functions as a tumor suppressor by targeting KLF15 in non-small cell lung cancer. European review for medical and pharmacological sciences 14 33015790
2016 Correlation of A2bAR and KLF4/KLF15 with Obesity-Dyslipidemia Induced Inflammation in Uygur Population. Mediators of inflammation 14 27199507
2014 A novel 2-bp indel within Krüppel-like factor 15 gene (KLF15) and its associations with chicken growth and carcass traits. British poultry science 14 25056727
2021 Myoepithelial Carcinoma of Soft Tissue With an EWSR1-KLF15 Gene Fusion in an Infant. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 13 33734915
2020 Teneligliptin Promotes Bile Acid Synthesis and Attenuates Lipid Accumulation in Obese Mice by Targeting the KLF15-Fgf15 Pathway. Chemical research in toxicology 13 32639145
2020 KLF15 reduces the level of apoptosis in mouse liver induced by sepsis by inhibiting p38MAPK/ERK1/2 signaling pathway. European review for medical and pharmacological sciences 13 33155243
2017 Estrogen receptor beta maintains expression of KLF15 to prevent cardiac myocyte hypertrophy in female rodents. Molecular and cellular endocrinology 13 29127073
2022 CTRP12 alleviates cardiomyocyte ischemia‑reperfusion injury via regulation of KLF15. Molecular medicine reports 12 35656890
2021 Inhibition of miR-431-5p attenuated liver apoptosis through KLF15/p53 signal pathway in S100 induced autoimmune hepatitis mice. Life sciences 12 34111466
2020 MiR-125a-3p-KLF15-BCAA Regulates the Skeletal Muscle Branched-Chain Amino Acid Metabolism in Nile Tilapia (Oreochromis niloticus) During Starvation. Frontiers in genetics 12 32849831
2017 Targeting and silencing of rhodopsin by ectopic expression of the transcription factor KLF15. JCI insight 12 29263295
2023 Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A. Translational oncology 11 36774884
2023 Hypoxic tumor cell-derived small extracellular vesicle miR-152-3p promotes cervical cancer radioresistance through KLF15 protein. Radiation oncology (London, England) 11 37936130
2023 Macrophage KLF15 prevents foam cell formation and atherosclerosis via transcriptional suppression of OLR-1. Journal of molecular and cellular cardiology 11 37984156
2014 KLF15 regulates slow myosin heavy chain expression through NFATc1 in C2C12 myotubes. Biochemical and biophysical research communications 11 24680826
2022 KLF15 controls brown adipose tissue transcriptional flexibility and metabolism in response to various energetic demands. iScience 10 36304102
2021 KLF15 Loss-of-Function Mutation Underlying Atrial Fibrillation as well as Ventricular Arrhythmias and Cardiomyopathy. Genes 10 33809104
2020 Transcriptome analysis of Klf15‑mediated inhibitory functions in a mouse deep venous thrombosis model. International journal of molecular medicine 10 32186780
2017 KLF15 regulates dopamine D2 receptor and participates in mouse models of neuropathic pain. Biochemical and biophysical research communications 10 28830816
2008 The Krüppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes. Biochemical and biophysical research communications 10 19094967
2024 KLF15 transcriptionally activates LINC00689 to inhibit colorectal cancer development. Communications biology 9 38273088
2024 Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in endometriosis. The Journal of endocrinology 9 38513352
2023 GR-KLF15 pathway controls hepatic lipogenesis during fasting. The FEBS journal 9 37702262
2021 FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin. iScience 9 34988390

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