Affinage

KIF7

Kinesin-like protein KIF7 · UniProt Q2M1P5

Length
1343 aa
Mass
150.6 kDa
Annotated
2026-06-10
45 papers in source corpus 19 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KIF7 is an immotile kinesin-4 family protein that functions as the core ciliary regulator of mammalian Hedgehog signal transduction, acting downstream of Smoothened and upstream of Gli2/Gli3 transcription factors as the vertebrate counterpart of Drosophila Costal2 (PMID:19666503, PMID:19549984). In unstimulated cells it resides at the base of the primary cilium, and Hedgehog activation drives its accumulation at the distal ciliary tip, where it is required for efficient Gli3 ciliary localization and processing into the GLI3 repressor form (PMID:19666503, PMID:19592253). At the cilium tip KIF7 binds the plus ends of growing microtubules, slows microtubule growth and increases catastrophe frequency, thereby limiting cilium length and organizing a single tip compartment in which Gli–Sufu activity is controlled (PMID:24952464). This regulatory output is bifunctional: KIF7 physically interacts with Gli proteins, sequesters them in cytoplasmic puncta, and both promotes dissociation of Sufu–Gli complexes (a positive, Sufu-dependent activity) and exerts Sufu-independent repressive functions, with halving Sufu dose genetically rescuing Kif7-null phenotypes (PMID:19549984, PMID:21795282, PMID:23034632, PMID:24339784). Its immotility arises from a failure to release ADP upon microtubule binding, converting it from a transporter into a microtubule-based tether of signaling complexes; this immotile behavior prevents inappropriate ciliary Gli localization without Hedgehog input (PMID:29351996, PMID:34705483). KIF7 activity is gated by auto-inhibition through an inhibitory coiled-coil whose disease-associated mutations relieve inhibition and cause aberrant microtubule binding (PMID:34114033), by PPFIA1/PP2A-mediated dephosphorylation that triggers ciliary tip trafficking (PMID:25492966), and by UBR3-mediated poly-ubiquitination and degradation (PMID:27195754); trafficking to the tip itself is executed by the kinesin-2 KIF3A/KIF3B/KAP intraflagellar transport motor (PMID:34705483). In mouse models, loss of KIF7 produces acrocallosal-syndrome features attributable to decreased GLI3R signaling, and KIF7 mutations deregulate GLI targets and impair GLI3 processing in human ciliopathy patients (PMID:21552264, PMID:30445565). Beyond canonical Hedgehog control, KIF7 governs enteric neural crest cell differentiation via a Kif7–Gli2–Ezh2 axis (PMID:34644112).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2009 High

    Established KIF7 as the missing vertebrate node of cilium-based Hedgehog transduction, placing it downstream of Smoothened and upstream of Gli transcription factors and linking it functionally to Drosophila Costal2.

    Evidence Genetic screen, eGFP-Kif7 live imaging with motor-domain mutants, Co-IP with Gli, and Kif7 knockout mice with Gli processing readouts

    PMID:19549984 PMID:19592253 PMID:19666503

    Open questions at the time
    • Did not resolve how Hedgehog-dependent tip trafficking is mechanically achieved
    • Did not distinguish KIF7's positive from negative regulatory activities at the molecular level
  2. 2011 High

    Defined KIF7 as a regulator of Sufu, showing it restricts Sufu inhibitory function and excludes Sufu-Gli complexes from cilia, with genetic Sufu-dose rescue establishing a direct epistatic relationship.

    Evidence Conditional knockout mice and Kif7-null x Sufu-heterozygous epistasis cross with ciliary localization assays

    PMID:21795282

    Open questions at the time
    • Mechanism of Sufu turnover by KIF7 not defined
    • Did not separate Sufu-dependent from Sufu-independent KIF7 functions
  3. 2011 High

    Connected KIF7 to human disease by showing patient mutations deregulate GLI targets and impair GLI3 processing, establishing clinical relevance for the ciliary Hedgehog role.

    Evidence Patient tissue GLI3 immunoblots, KIF7 sequencing in ciliopathy cohorts, and zebrafish knockdown epistasis

    PMID:21552264

    Open questions at the time
    • Did not establish biochemical mechanism by which mutations disrupt processing
  4. 2011 Medium

    Implicated KIF7 in broader ciliogenesis and cytoskeletal homeostasis through interaction with nephrocystin-1 and effects on centrosomes, Golgi, and tubulin acetylation.

    Evidence Co-IP with NPHP1 and siRNA knockdown with cilia, centrosome, Golgi, and tubulin acetylation readouts

    PMID:21633164

    Open questions at the time
    • Single lab without reciprocal validation
    • Relationship between NPHP1 interaction and Hedgehog functions unresolved
  5. 2012 High

    Dissected KIF7's dual nature into Sufu-dependent (Gli dissociation) and Sufu-independent repressive activities, and provided a crystal structure of the motor domain to ground its mechanism.

    Evidence Skin-specific conditional knockouts with Sufu/Kif7 double-mutant epistasis, plus X-ray crystallography of the recombinant human motor domain

    PMID:22281744 PMID:23034632

    Open questions at the time
    • Structure did not explain immotility mechanistically
    • Molecular identity of the Sufu-independent repressive activity unresolved
  6. 2013 High

    Confirmed cross-species conservation by showing zebrafish Kif7 sequesters Gli in cytoplasmic puncta, mediates a Smoothened-dependent Gli2a modification, and can be functionally replaced by Drosophila Cos2.

    Evidence Zinc-finger-nuclease kif7 mutants, Co-IP with Gli1/Gli2a, puncta imaging, and Cos2 rescue

    PMID:24339784

    Open questions at the time
    • Nature of the Smoothened-dependent Gli2a modification not identified
  7. 2014 High

    Revealed the biochemical core of KIF7's function: it binds microtubule plus ends to suppress growth and promote catastrophe, building the single ciliary tip compartment where Gli-Sufu is regulated, independent of intraflagellar transport.

    Evidence In vitro TIRF microscopy of purified KIF7 on growing microtubules plus mouse mutant and live-cell cilium imaging

    PMID:24952464

    Open questions at the time
    • Did not explain how an immotile kinesin reaches the tip
    • Did not define the tip-localization signal
  8. 2014 High

    Identified post-translational control of KIF7 trafficking, showing PPFIA1/PP2A dephosphorylate KIF7 to trigger ciliary tip localization and Gli activity.

    Evidence AP-MS, Co-IP validation, phosphorylation assays, and functional rescue

    PMID:25492966

    Open questions at the time
    • Kinase opposing this dephosphorylation not identified
    • Phosphosite mapping incomplete
  9. 2016 Medium

    Added degradative control, demonstrating that the E3 ligase UBR3 poly-ubiquitinates KIF7 to limit its abundance and tune Hedgehog output.

    Evidence In vitro ubiquitination assay and UBR3 knockdown with KIF7 protein and Hh readouts

    PMID:27195754

    Open questions at the time
    • Single lab without in vivo confirmation
    • Ubiquitination sites and degradation context not mapped
  10. 2018 High

    Explained KIF7's defining immotility, showing it cannot release ADP upon microtubule binding and thus acts as a tether rather than a transporter.

    Evidence In vitro single-molecule motility, ATPase kinetics, and ADP-release assays across kinesin-4 members

    PMID:29351996

    Open questions at the time
    • Did not address how the immotile tether is delivered to the cilium tip
  11. 2019 High

    Defined the pathway hierarchy underlying KIF7 disease phenotypes, attributing acrocallosal-syndrome features to decreased GLI3R and corpus callosum defects partly to increased FGF8 signaling.

    Evidence Kif7-null x Gli3Δ699 genetic rescue and FGF8 modifier crosses with cortical patterning analysis

    PMID:30445565

    Open questions at the time
    • Did not resolve cell-autonomous versus tissue-level contributions
  12. 2021 High

    Reconciled trafficking and microtubule binding by showing kinesin-2 IFT carries KIF7 to the tip while KIF7 microtubule binding is dispensable for tip accumulation, and that immotility prevents basal ciliary Gli localization.

    Evidence KIF7 microtubule-binding/motility variant panel, acute engineered IFT inhibition, and Gli localization assays

    PMID:34705483

    Open questions at the time
    • How KIF7 cargo recognition by IFT is achieved not defined
  13. 2021 High

    Identified auto-inhibition via an inhibitory coiled-coil as the conformational switch governing microtubule binding and tip localization, with disease mutations relieving inhibition.

    Evidence inhCC mutagenesis, disease-allele analysis, microtubule-binding and live-cell imaging

    PMID:34114033

    Open questions at the time
    • Signal that physiologically relieves auto-inhibition unresolved
  14. 2021 High

    Extended KIF7 function beyond canonical patterning to enteric neural crest differentiation through a Kif7-Gli2-Ezh2 axis, with KIF7 loss reducing inhibitory enteric neurons and impairing gut motility.

    Evidence Neural-crest-specific conditional knockout with Gli2-deletion and Ezh2-inhibition rescues and human ENCC differentiation assays

    PMID:34644112

    Open questions at the time
    • miR124-Ezh2 regulatory detail downstream of Gli2 not fully mapped
  15. 2017 Medium

    Proposed a Hedgehog-independent tumor-suppressive role in which the KIF7 coiled-coil enhances LKB1 to engage PTEN and suppress AKT in prostate cancer cells.

    Evidence Ectopic KIF7-CC expression with LKB1/PTEN/AKT immunoblots, LKB1 siRNA rescue, and xenografts

    PMID:28903364

    Open questions at the time
    • Single lab; relationship to ciliary KIF7 functions unclear
    • Direct LKB1-KIF7 interaction not established
  16. 2013 Low

    Reported a host-pathogen interaction in which Pseudomonas ExoS binds KIF7's N-terminal domain, with KIF7 silencing causing cytotoxicity.

    Evidence Yeast two-hybrid, pull-down with partial domain constructs, and KIF7 siRNA cytotoxicity readout

    PMID:24462444

    Open questions at the time
    • Yeast two-hybrid and single pull-down without reciprocal validation
    • Cytotoxicity readout indirect
    • Physiological relevance uncertain
  17. 2024 Medium

    Began resolving the temporal logic of Gli2 transport, indicating KIF7 coordinates an anterograde-biased IFT window for GLI2 tip localization following Hedgehog activation.

    Evidence Real-time single-particle GLI2 imaging in cilia with KIF7 mutants and IFT perturbation (preprint)

    Open questions at the time
    • Preprint, not peer-reviewed
    • Mechanism by which KIF7 sets the timing window undefined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the multiple regulatory layers (auto-inhibition, dephosphorylation, ubiquitination, IFT delivery) are integrated in time to switch KIF7 between repressive and activating modes during a single Hedgehog response remains unresolved.
  • No integrated kinetic model of KIF7 mode-switching
  • Kinase counteracting PPFIA1/PP2A not identified
  • Physiological trigger relieving auto-inhibition unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 3 GO:0098772 molecular function regulator activity 3 GO:0060090 molecular adaptor activity 2 GO:0140657 ATP-dependent activity 1
Localization
GO:0005929 cilium 3 GO:0005856 cytoskeleton 2 GO:0005815 microtubule organizing center 1 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1266738 Developmental Biology 2
Partners
GLI1GLI2GLI3KIF3ANPHP1PPFIA1SUFUUBR3

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 Kif7 is a cilia-associated protein that acts downstream of Smoothened (Smo) and upstream of Gli2/Gli3 transcription factors in mammalian Hedgehog signaling; in the absence of Shh it localizes to the base of the primary cilium, and Shh activation promotes trafficking of Kif7-eGFP to the cilium tip in a motor-domain-dependent manner. Genetic screen (reporter-based mutant allele), eGFP-tagged Kif7 live imaging in mouse embryo cells, motor domain mutant analysis Proceedings of the National Academy of Sciences of the United States of America High 19666503
2009 Kif7 physically interacts with Gli transcription factors, controls their proteolysis and stability, and acts both positively and negatively in Hedgehog signaling, paralleling the role of Drosophila Costal2. Co-immunoprecipitation of Kif7 with Gli proteins; Kif7 knockout mice with Gli processing readouts Science signaling High 19549984
2009 Kif7 accumulates at the distal tip of primary cilia in a Hedgehog-dependent manner and is required for efficient localization of Gli3 to cilia and for processing of Gli3 into its repressor form. Kif7 knockout mouse; immunofluorescence of Gli3 in cilia; immunoblot of Gli3 processing Current biology : CB High 19592253
2011 Kif7 promotes Hedgehog pathway activity by restricting the inhibitory function of Sufu: Kif7 plays a role in Sufu turnover and exclusion of Sufu-Gli complexes from the primary cilium; genetic rescue by halving Sufu dose restores normal pathway activity in Kif7-null chondrocytes. Conditional knockout mice; epistasis (Kif7-null × Sufu heterozygous cross); immunofluorescence of Sufu-Gli complexes in cilia Development (Cambridge, England) High 21795282
2011 KIF7 co-precipitates with nephrocystin-1 (NPHP1); knockdown of KIF7 causes defects in cilia formation, abnormal centrosomal duplication, and fragmentation of the Golgi network, linked to abnormal tubulin acetylation and microtubule dynamics. Co-immunoprecipitation of KIF7 with nephrocystin-1; siRNA knockdown in cell lines; immunofluorescence of cilia, centrosomes, and Golgi; tubulin acetylation assay The Journal of clinical investigation Medium 21633164
2011 KIF7 mutations cause deregulation of GLI transcription factor targets and impaired GLI3 processing in human patient tissues, establishing KIF7 as a regulator of GLI3 processing in human primary cilia. Patient tissue analysis; immunoblot of GLI3 processing; sequencing of KIF7 in ciliopathy cohorts; in vivo genetic interaction (zebrafish knockdown epistasis) Nature genetics High 21552264
2012 Sufu restricts Gli2 activity through cytoplasmic sequestration; Kif7 possesses both Sufu-dependent functions (promoting dissociation of Sufu-Gli2 complex) and Sufu-independent repressive functions in Hh signaling in keratinocytes; simultaneous deletion of both Sufu and Kif7 in embryonic skin abolishes follicular fate. Conditional knockout mice (skin-specific); double-knockout epistasis; localization assays for Sufu-Gli2 complexes Development (Cambridge, England) High 23034632
2012 Crystal structure of the human Kif7 motor domain was determined at high resolution, revealing structural features shared with and distinct from conventional kinesin. X-ray crystallography of recombinant human Kif7 motor domain Acta crystallographica. Section D, Biological crystallography High 22281744
2013 Kif7 interacts with Gli1 and Gli2a in zebrafish, sequesters Gli proteins in cytoplasmic puncta, promotes Gli2a dissociation from Sufu, and mediates a Smoothened-dependent modification of full-length Gli2a; cytoplasmic Kif7 puncta disperse in response to Hh pathway activation. Drosophila Costal2 can substitute for Kif7 in zebrafish. Zinc finger nuclease-induced kif7 mutant alleles; co-immunoprecipitation of Kif7 with Gli1 and Gli2a; immunofluorescence of cytoplasmic Kif7 puncta; rescue with Drosophila Cos2 PLoS genetics High 24339784
2014 Kif7 localizes to the cilium tip where it binds the plus ends of growing microtubules, reduces the rate of microtubule growth, and increases the frequency of microtubule catastrophe; this activity limits cilium length and controls cilium architecture, creating a single cilium tip compartment where Gli-Sufu activity is regulated. Kif7 is not required for intraflagellar transport or trafficking of Hh pathway proteins into cilia. In vitro TIRF microscopy of purified recombinant Kif7 on growing microtubules; mouse Kif7 mutant analysis; live-cell imaging of cilia Nature cell biology High 24952464
2014 Liprin-α1 (PPFIA1) and the protein phosphatase PP2A were identified as Kif7-interacting proteins by mass spectrometry; PPFIA1 and PP2A promote dephosphorylation of Kif7, triggering Kif7 localization to ciliary tips and promoting Gli transcriptional activity. Affinity purification–mass spectrometry (AP-MS) of Kif7; co-immunoprecipitation validation; phosphorylation assays; functional rescue experiments Science signaling High 25492966
2016 UBR3, an E3 ubiquitin ligase, poly-ubiquitinates Kif7 (mammalian homologue of Cos2), leading to its degradation; loss of UBR3 upregulates Kif7 protein levels and decreases Hh signaling in cultured cells. In vitro ubiquitination assay with mouse UBR3 and Kif7; Western blot of Kif7 levels upon UBR3 knockdown; Hh signaling readout PLoS genetics Medium 27195754
2018 KIF7 (and its Drosophila homologue Costal2) is immotile because it cannot release ADP in response to microtubule binding (defective mechanochemical coupling), enabling it to function as a microtubule-based tether of signaling complexes rather than a transporter. In vitro single-molecule motility assays; ATPase kinetics; ADP release assays; comparison of kinesin-4 family members The Journal of cell biology High 29351996
2019 Decreased GLI3R signaling is fully responsible for acrocallosal syndrome features in Kif7-null mice (rescued by crossing with Gli3Δ699 mice producing only GLI3R); increased FGF8 signaling is responsible in part for corpus callosum defects associated with KIF7 depletion. Kif7-null × Gli3Δ699 genetic rescue experiment; crossing with FGF8 signaling modifiers; cortical patterning analysis Human molecular genetics High 30445565
2021 KIF7 is regulated by auto-inhibition mediated by an inhibitory coiled-coil (inhCC) segment; disease-associated mutations in the inhCC relieve auto-inhibition and result in strong microtubule binding. Uninhibited KIF7 binds along cytosolic and axonemal microtubules rather than preferentially at plus ends in cells. Localization to the cilium tip also requires the inhCC. Microtubule binding assays in cells; mutagenesis of inhCC; disease-associated mutant analysis; live-cell imaging Journal of cell science High 34114033
2021 KIF7's microtubule binding is not required for Hedgehog-induced increase in KIF7 or Gli localization at the cilium tip; instead, kinesin-2 KIF3A/KIF3B/KAP (intraflagellar transport) mediates translocation of KIF7 to the cilium tip in response to Hh pathway activation. The immotile behavior of KIF7 is required to prevent ciliary localization of Gli transcription factors in the absence of Hh signaling. KIF7 microtubule-binding and motility variants; acute inhibition of intraflagellar transport via engineered kinesin-2 motor; Gli localization assays Molecular biology of the cell High 34705483
2021 In enteric neural crest cells, Kif7 inhibits Gli2, which in turn positively regulates Ezh2 expression by inhibiting miR124-mediated suppression; Ezh2 controls differentiation of enteric neural crest cells. Neural-crest-specific Kif7 deficiency causes a marked reduction of enteric NOS+ inhibitory neurons and gut motility defects. Neural-crest-specific Kif7 conditional knockout mice; Gli2 deletion rescue; Ezh2 inhibition rescue; human ENCC differentiation assays Science advances High 34644112
2017 The KIF7 coiled-coil (CC) domain enhances LKB1 expression and phosphorylation at Ser428, which induces PTEN phosphorylation and consequently blocks AKT phosphorylation at Ser473, attenuating prostate cancer cell proliferation and migration. Downregulation of LKB1 abrogates the anti-tumor effects of KIF7-CC. Ectopic expression of KIF7-CC domain in prostate cancer cell lines; Western blot of LKB1, pLKB1, PTEN, pAKT; LKB1 siRNA rescue; xenograft in vivo studies Oncotarget Medium 28903364
2013 The ADPRT domain (residues 234-354) of Pseudomonas aeruginosa ExoS toxin binds to the N-terminal domain (residues 1-109) of KIF7, and silencing KIF7 expression causes cytotoxicity in human bronchial epithelial cells, suggesting ExoS can induce cytotoxicity by interacting with KIF7. Yeast two-hybrid screen; pull-down assay; KIF7 siRNA knockdown with cytotoxicity readout Journal of infection and chemotherapy Low 24462444
2024 KIF7 is critical for the temporal control of Gli2 transport by IFT machinery and for spatial control of Gli2 localization at the cilium tip; IFT transports GLI2 with anterograde bias during a restricted time window following Hh pathway activation, and KIF7 coordinates this process. Real-time single-particle imaging of GLI2 within cilia; KIF7 mutant analysis; IFT machinery perturbation bioRxivpreprint Medium

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment. Nature cell biology 234 24952464
2009 Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proceedings of the National Academy of Sciences of the United States of America 229 19666503
2009 The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Current biology : CB 189 19592253
2009 The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. Science signaling 186 19549984
2011 KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes. Nature genetics 185 21552264
2011 Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics. The Journal of clinical investigation 163 21633164
2012 Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis. Development (Cambridge, England) 62 23034632
2014 The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling. Science signaling 48 25492966
2011 Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu. Development (Cambridge, England) 47 21795282
2013 Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo. PLoS genetics 44 24339784
2012 Novel KIF7 mutations extend the phenotypic spectrum of acrocallosal syndrome. Journal of medical genetics 32 23125460
2018 Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7. The Journal of cell biology 31 29351996
2012 A mutation in KIF7 is responsible for the autosomal recessive syndrome of macrocephaly, multiple epiphyseal dysplasia and distinctive facial appearance. Orphanet journal of rare diseases 30 22587682
2013 Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia. Proceedings of the National Academy of Sciences of the United States of America 27 23650387
2018 Clinical and experimental evidence suggest a link between KIF7 and C5orf42-related ciliopathies through Sonic Hedgehog signaling. European journal of human genetics : EJHG 24 29321670
2021 Mutations in KIF7 implicated in idiopathic scoliosis in humans and axial curvatures in zebrafish. Human mutation 23 33382518
2004 Characterization of KIF7 gene in silico. International journal of oncology 23 15547730
2012 Structural insights into human Kif7, a kinesin involved in Hedgehog signalling. Acta crystallographica. Section D, Biological crystallography 22 22281744
2012 Acrocallosal syndrome: identification of a novel KIF7 mutation and evidence for oligogenic inheritance. European journal of medical genetics 21 23142271
2019 Altered GLI3 and FGF8 signaling underlies acrocallosal syndrome phenotypes in Kif7 depleted mice. Human molecular genetics 20 30445565
2017 Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms. Developmental biology 19 28341548
2017 The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus. Oncotarget 19 28445929
2016 Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination. PLoS genetics 17 27195754
2015 The many faces of KIF7. Human genome variation 17 27081521
2012 Antagonistic and cooperative actions of Kif7 and Sufu define graded intracellular Gli activities in Hedgehog signaling. PloS one 17 23166838
2015 Sufu and Kif7 in limb patterning and development. Developmental dynamics : an official publication of the American Association of Anatomists 15 25581370
2015 Novel KIF7 missense substitutions in two patients presenting with multiple malformations and features of acrocallosal syndrome. American journal of medical genetics. Part A 14 26174511
2014 Kif7 keeps cilia tips in shape. Nature cell biology 14 24981634
2009 Hedgehog signalling: Kif7 is not that fishy after all. Current biology : CB 14 19906571
2015 Kif7 expression is decreased in the diaphragmatic and pulmonary mesenchyme of nitrofen-induced congenital diaphragmatic hernia. Journal of pediatric surgery 13 25921351
2015 Novel KIF7 Mutation in a Tunisian Boy with Acrocallosal Syndrome: Case Report and Review of the Literature. Molecular syndromology 13 26648833
2014 Downregulation of the gli transcription factors regulator Kif7 facilitates cell survival and migration of choriocarcinoma cells. PloS one 13 25265279
2021 Sequences in the stalk domain regulate auto-inhibition and ciliary tip localization of the immotile kinesin-4 KIF7. Journal of cell science 12 34114033
2017 KIF7 attenuates prostate tumor growth through LKB1-mediated AKT inhibition. Oncotarget 12 28903364
2021 Ciliary protein Kif7 regulates Gli and Ezh2 for initiating the neuronal differentiation of enteric neural crest cells during development. Science advances 10 34644112
2021 Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7's microtubule binding. Molecular biology of the cell 10 34705483
2015 KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms. PLoS genetics 9 26439735
2008 Cloning and developmental expression of kinesin superfamily7 (kif7) in the brackish medaka (Oryzias melastigma), a close relative of the Japanese medaka (Oryzias latipes). Marine pollution bulletin 9 18423496
2020 Human papillomavirus 16 (HPV 16) E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7. Thoracic cancer 8 32945133
2015 A novel KIF7 mutation in two affected siblings with acrocallosal syndrome. Clinical dysmorphology 7 25714560
2013 ExoS of Pseudomonas aeruginosa binds to a human KIF7 to induce cytotoxicity in cultured human bronchial epithelial cells. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 3 24462444
2024 Retinitis Pigmentosa Sine Pigmento in a Patient With a Heterozygous Mutation on the KIF7 Gene: A Case Report. Cureus 2 39036105
2025 Genetic Variants in KIF7 May Contribute to Supernumerary Tooth Formation. International dental journal 1 40774045
2025 Expansion of Phenotyping and Genotypic Spectra of KIF7 -Related Intellectual Disability: Case Report and Review of Literature. American journal of medical genetics. Part A 0 40935806
2025 The ciliary kinesin KIF7 controls the development of the cerebral cortex by acting differentially on SHH signaling in dorsal and ventral forebrain. eLife 0 40956303

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