Affinage

KIF3B

Kinesin-like protein KIF3B · UniProt O15066

Length
747 aa
Mass
85.1 kDa
Annotated
2026-06-10
40 papers in source corpus 17 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KIF3B is the motor subunit of the heterotrimeric kinesin-2 complex (KIF3A/KIF3B/KAP3) that drives microtubule-based anterograde transport underlying ciliogenesis and selective intracellular cargo delivery (PMID:9865700, PMID:25175706). In cilia, KIF3B powers anterograde intraflagellar transport (IFT), and its loss abolishes nodal monocilia, eliminates leftward nodal flow, and randomizes left-right body asymmetry (PMID:9865700). Entry of the motor into the cilium and turnaround at the tip are gated by calcium-dependent phosphorylation of the conserved residue S663, which disrupts the kinesin-II/IFT-B interaction and inactivates the motor; this phosphorylation is the effector of a flagellar length-sensing feedback loop, accumulating in long cilia to throttle further IFT entry (PMID:25175706, PMID:30057303). Beyond cilia, KIF3B transports a diverse cargo repertoire along microtubules: MT1-MMP vesicles required for matrix degradation at macrophage podosomes (PMID:20505159), CLC-5 and the anion exchanger kAE1 to the kidney plasma membrane (PMID:19940036, PMID:21871436), and NR2A/APC-containing vesicles to neuronal dendrites, where KIF3B haploinsufficiency reduces NMDAR levels and synaptic plasticity and a schizophrenia-associated variant is transport-defective (PMID:31746486). Motor activity is held in check by autoinhibition: a conserved beta-hairpin motif in the kinesin-2 tail sequesters the motor domains by molecular mimicry, and KAP3 provides a multipartite platform for cargo adaptors that occlude this motif to license motility. Heterozygous KIF3B missense variants cause a dominant ciliopathy with retinitis pigmentosa and polydactyly; mechanistically, the motor-domain E250Q behaves as a rigor mutation that decorates microtubules and fails to rescue ciliogenesis, while the stalk L523P preserves complex assembly but impairs motility (PMID:32386558, PMID:38665936). KIF3B also delivers the Talpid3 phosphatase to terminate PI3K signaling and shape Shh gradients during limb patterning (PMID:36220081).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1998 High

    Establishing that KIF3B is genetically required for cilium assembly and left-right axis specification answered whether this motor has an essential developmental function.

    Evidence Knockout mouse with cilia localization, motility/fluid-flow video microscopy, and lefty-2 expression analysis

    PMID:9865700

    Open questions at the time
    • Did not resolve which cargoes or IFT machinery KIF3B carries into the cilium
    • Mechanism linking ciliary loss to asymmetry randomization inferred from flow defect
  2. 2014 High

    Identification of S663 phosphorylation as a switch that disrupts kinesin-II/IFT-B binding explained how IFT entry and tip turnaround are gated rather than constitutive.

    Evidence Phosphosite mapping, site-directed mutagenesis, in vivo IFT assays and co-IP in Chlamydomonas FLA8/KIF3B

    PMID:25175706

    Open questions at the time
    • Kinase identity defined only as calcium-dependent
    • Conservation of this switch in mammalian KIF3B not directly tested
  3. 2018 High

    Linking pFLA8 levels to flagellar length defined KIF3B phosphorylation as the effector of a length-sensing feedback loop controlling ciliary assembly.

    Evidence Phosphatase (CrPP1/CrPP6) depletion with pFLA8 quantification and IFT entry measurements in Chlamydomonas

    PMID:30057303

    Open questions at the time
    • How length information is converted into kinase/phosphatase activity not established
    • Phosphatase specificity in vivo not fully resolved
  4. 2009 High

    Demonstrating direct KIF3B–CLC-5 binding and transport extended KIF3B function beyond cilia to membrane-protein trafficking and endocytic regulation in kidney cells.

    Evidence Yeast two-hybrid, GST pull-down, reciprocal co-IP, live imaging, siRNA, endocytosis assays

    PMID:19940036

    Open questions at the time
    • Requirement for full KIF3A/KAP3 complex not dissected
    • In vivo renal consequences not tested
  5. 2011 Medium

    Mapping kAE1 and RNF33/TRIM60 binding to the KIF3B tail clarified how non-ciliary cargo and regulatory proteins engage the motor's non-motor domain.

    Evidence Co-IP, yeast two-hybrid, and deletion mapping of dileucine motif (kAE1) and RB/B30.2 domains (RNF33)

    PMID:21871436 PMID:21909995

    Open questions at the time
    • No in vivo transport rescue for either interaction
    • Functional role of RNF33 binding (KAP3-independent) on transport not measured
  6. 2010 Medium

    Showing KIF3A/KIF3B delivers MT1-MMP vesicles connected the motor to matrix degradation and surface receptor shedding in macrophages.

    Evidence siRNA knockdown, live vesicle imaging, surface expression and podosome ECM degradation assays

    PMID:20505159

    Open questions at the time
    • KIF3A and KIF3B contributions not individually separated
    • Direct cargo adaptor not identified
  7. 2019 High

    Demonstrating co-transport of NR2A/APC vesicles and rescue failure of a disease variant tied KIF3B to synaptic NMDAR delivery and plasticity, with a human psychiatric link.

    Evidence Heterozygous knockout mouse, vesicle co-IP, hippocampal electrophysiology, behavior, human variant rescue

    PMID:31746486

    Open questions at the time
    • Causal contribution of KIF3B variant to disease in patients not established beyond cellular rescue
    • Mechanism of NR2B degradation downstream of reduced transport not detailed
  8. 2020 Medium

    Characterizing the neuronal morphological phenotype showed KIF3B acts as a constraint on dendritic spine density and branching in post-mitotic neurons.

    Evidence RNAi knockdown and overexpression in cortical neurons with morphology and PSD-95 imaging

    PMID:33192305

    Open questions at the time
    • Pathway connecting transport activity to spine number not defined
    • Relationship to NR2A transport function not integrated
  9. 2020 Medium

    Identifying heterozygous KIF3B missense variants causing retinitis pigmentosa and polydactyly established KIF3B as a dominant ciliopathy gene.

    Evidence Patient exome sequencing, in vitro cilia length assay, zebrafish rhodopsin trafficking, feline GWAS/WGS

    PMID:32386558

    Open questions at the time
    • Molecular basis of cilia length increase not resolved at this stage
    • Dominant-negative vs haploinsufficient mechanism unclear
  10. 2022 Medium

    Connecting KIF3B to Talpid3 transport and PI3K termination explained how the motor shapes Shh and FGF gradients during limb patterning.

    Evidence Hypomorphic mouse genetics, bead transplantation, fractionation, immunofluorescence of Shh/PI3K/Talpid3

    PMID:36220081

    Open questions at the time
    • Talpid3 transport inferred from loss-of-function, not reconstituted
    • Direct KIF3B–Talpid3 binding not shown
  11. 2024 Medium

    Allele-resolved rescue assays defined distinct molecular defects for disease mutations, separating rigor binding (E250Q), motility impairment (L523P), and load-dependent defects (A334T).

    Evidence Kif3a;Kif3b double-knockout 3T3 rescue, ciliogenesis, microtubule decoration, Golgi dispersal, complex formation assays

    PMID:38665936

    Open questions at the time
    • Single lab, cell-based assays only
    • In vivo correspondence of each allele's defect not tested
  12. 2024 Medium

    Structural definition of a tail beta-hairpin autoinhibition motif and the KAP3 cargo-adaptor platform explained how kinesin-2 motility is switched on by cargo engagement.

    Evidence Cryo-EM, single-molecule motility, and beta-hairpin mutagenesis (preprint)

    Open questions at the time
    • Preprint, not yet peer-reviewed
    • Which physiological cargo adaptors occlude the motif in cells not enumerated
  13. 2026 Medium

    Discovery of a KIF3B-enriched, TRIM46-associated kinesin-2 assembly distinct from the canonical heterotrimer indicated assembly-state diversity may underlie cargo selectivity.

    Evidence Biochemical fractionation, co-IP, imaging, and tail conformation structural analysis

    PMID:41910726

    Open questions at the time
    • Stoichiometry and composition of the alternative assembly not fully defined
    • Functional consequence for axon initial segment in vivo not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How distinct cargo adaptors (e.g. 14-3-3ε, KAP3-linked factors) and tail conformations are selected to direct KIF3B to specific cargoes in different cell types remains unresolved.
  • No unified model linking adaptor identity to cargo specificity
  • In vitro 14-3-3ε binding lacks functional transport validation

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003774 cytoskeletal motor activity 4 GO:0008092 cytoskeletal protein binding 3 GO:0140657 ATP-dependent activity 2
Localization
GO:0005856 cytoskeleton 3 GO:0005929 cilium 3 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-9609507 Protein localization 4 R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-1266738 Developmental Biology 2
Partners
APCCLC-5ITGB1KAE1KAP3KIF3ARNF33/TRIM60TRIM46
Complex memberships
kinesin-2 (KIF3A/KIF3B/KAP3) heterotrimer

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 KIF3B is localized to nodal monocilia and is essential for their assembly; loss of KIF3B abolishes nodal cilia while basal bodies remain present, eliminating leftward nodal fluid flow and randomizing left-right asymmetry in mice. Gene targeting (knockout mouse), immunocytochemistry for KIF3B in nodal cilia, video microscopy of cilia motility and fluid flow, lefty-2 expression analysis Cell High 9865700
2014 The KIF3B homolog FLA8 in Chlamydomonas is phosphorylated at the conserved residue S663 by a calcium-dependent kinase; this phosphorylation disrupts the interaction between kinesin-II and the IFT-B complex, inactivates kinesin-II, blocks IFT entry into cilia, and is required for IFT-B unloading at the ciliary tip, acting as a molecular switch controlling IFT entry and turnaround. Phosphorylation site identification, site-directed mutagenesis, in vivo IFT assays, co-immunoprecipitation of kinesin-II with IFT-B, cellular fractionation Developmental cell High 25175706
2018 Cellular signaling in response to changes in flagellar length regulates phosphorylation of FLA8/KIF3B: phosphorylated FLA8 levels are low in cells with short flagella and high in cells with long flagella. Depletion of phosphatases CrPP1 and CrPP6 increases pFLA8, decreasing IFT entry and flagellar length, demonstrating that KIF3B phosphorylation is the effector of a length-sensing mechanism controlling ciliary assembly. Phosphatase depletion (siRNA), quantification of pFLA8 levels vs. flagellar length, IFT entry measurements, Chlamydomonas genetics Current biology : CB High 30057303
2009 CLC-5 (chloride/proton antiporter) physically interacts with KIF3B via the CLC-5 C-terminus and the KIF3B coiled-coil and globular domains; KIF3B transports CLC-5-containing vesicles along microtubules in kidney cells, and KIF3B knockdown decreases CLC-5 surface expression and endocytosis of albumin and transferrin while overexpression has reciprocal effects. Yeast two-hybrid, GST pull-down, co-immunoprecipitation (endogenous), confocal live-cell imaging, siRNA knockdown, whole-cell chloride current measurement, endocytosis assays American journal of physiology. Renal physiology High 19940036
2010 KIF3A/KIF3B kinesin drives anterograde transport of MT1-MMP-positive vesicles along microtubules in primary human macrophages; siRNA-mediated knockdown of KIF3A/KIF3B impairs MT1-MMP delivery to the cell surface, shedding of CD44 and syndecan-1, and degradation of extracellular matrix at podosomes. siRNA knockdown, live-cell imaging of vesicle movement along microtubules, surface expression assay, ECM degradation assay at podosomes Blood Medium 20505159
2011 RING/TRIM protein RNF33/TRIM60 interacts with KIF3A and KIF3B through its RB and B30.2 domains binding the respective C-terminal non-motor (tail) domains of KIF3A and KIF3B; this interaction occurs independently of the KAP3 adaptor, leaving the motor head free for microtubule-based movement. Yeast two-hybrid, co-immunoprecipitation, deletion mapping Molecular and cellular biochemistry Medium 21909995
2011 Human kidney anion exchanger 1 (kAE1) interacts with KIF3B via a dileucine motif at the kAE1 C-terminus; KIF3B knockdown by siRNA reduces membrane localization of kAE1 and increases its intracellular accumulation, indicating KIF3B mediates kAE1 trafficking to the plasma membrane. Co-immunoprecipitation, siRNA knockdown, immunofluorescence colocalization in kidney tissue and cells Biochemical and biophysical research communications Medium 21871436
2019 KIF3B transports vesicles simultaneously containing NMDAR subunit NR2A (GluN2A) and the APC complex in neurons; Kif3b+/- neurons show reduced dendritic levels of NR2A and NR2B (NR2B due to increased degradation), decreased NMDAR electrophysiological responses, and disrupted synaptic plasticity. A human SCZ-associated KIF3B mutation is functionally defective in a rescue experiment. Heterozygous knockout mouse, vesicle co-fractionation/co-IP of NR2A and APC with KIF3B, electrophysiology in hippocampal slices, behavioral assays, rescue experiment with human variant The EMBO journal High 31746486
2020 Heterozygous human KIF3B missense variants (E250Q in the motor domain; L523P in the stalk) cause dominant ciliopathy with retinitis pigmentosa and polydactyly; mutant KIF3B proteins increase primary cilia length in vitro and impair rhodopsin trafficking in photoreceptors in zebrafish. Exome sequencing of patients, in vitro cilia length measurement, zebrafish mRNA injection and rhodopsin trafficking assay, genome-wide association study + whole-genome sequencing in Bengal cats American journal of human genetics Medium 32386558
2022 KIF3B transports the PTEN-like phosphatase Talpid3 to terminate PI3K signaling in limb bud cells; loss of KIF3B motor activity in hypomorphic mice disrupts a distal-to-proximal FGF/PI3K gradient and a posterior-to-anterior Shh gradient, causing preaxial polydactyly. High vs. low PI3K signaling differentially sorts endocytosed Shh into exosome-like particles vs. cytonemal puncta, establishing a Shh spatial gradient. KIF3B hypomorphic mouse genetics, bead transplantation experiments, subcellular fractionation, immunofluorescence of Shh/PI3K/Talpid3 distribution Developmental cell Medium 36220081
2024 Disease-causing KIF3B mutation E250Q (motor domain) is a rigor mutation that causes the motor to decorate microtubules and fails to rescue ciliogenesis; L523P (stalk/coiled-coil domain) does not disrupt KIF3A/KIF3B/KAP3 complex formation but impairs motility along microtubules; A334T reduces motor protein levels and impairs Golgi dispersal under high load but restores ciliogenesis to wild-type levels. Kif3a;Kif3b double-knockout 3T3 cell rescue assay, ciliogenesis quantification, fluorescent tagging/microtubule decoration assay, Golgi dispersal assay, complex formation assessment Frontiers in molecular biosciences Medium 38665936
2020 KIF3B knockdown in primary cortical neurons increases dendritic spine density (thin and mushroom spines), increases dendritic branching, and elevates PSD-95 distribution; KIF3B overexpression reduces spine density and branching, demonstrating that KIF3B functions as an inhibitory constraint on structural plasticity in post-mitotic neurons. RNAi knockdown and overexpression in primary cortical neurons, confocal imaging of dendritic morphology, immunostaining for PSD-95 Frontiers in cellular neuroscience Medium 33192305
2021 KIF3B silencing in breast cancer cells decreases the expression of Dvl2, phospho-GSK-3β, and nuclear β-catenin and downregulates Wnt/β-catenin target genes (CyclinD1, c-Myc, MMP-2, MMP-7, MMP-9), and inhibits epithelial-mesenchymal transition, placing KIF3B upstream of the Wnt/β-catenin pathway. siRNA knockdown in breast cancer cell lines, western blot for pathway components, in vivo xenograft Frontiers in oncology Low 33542902
2023 YY1 transcriptionally activates KIF3B; KIF3B in turn interacts with Integrin-beta1 (ITGB1) to inactivate the Hippo signaling pathway (reducing YAP1 phosphorylation and nuclear exclusion), conferring radioresistance in esophageal squamous cell carcinoma cells. Multi-group sequencing, siRNA knockdown, co-immunoprecipitation of KIF3B with ITGB1, Hippo pathway component western blot, in vitro and in vivo radiosensitivity assays Cell death & disease Low 38065955
2025 High-resolution cryo-EM structures of the KIF3A/KIF3B/KAP3 heterotrimer bound to APC cargo reveal a previously uncharacterized 'Hitchdock domain' in the KIF3 tail; KIF3A helical regions mediate APC cargo binding while KIF3B provides structural support; the β-hairpin region and KAP3 interface are also defined. Mutagenesis and MD simulations confirm functional importance of the Hitchdock domain. Cryo-electron microscopy, mutagenesis, molecular dynamics simulations bioRxivpreprint Medium
2024 A conserved beta-hairpin motif in the kinesin-2 tail (including KIF3B) mediates autoinhibition by sequestering motor domains away from microtubules via molecular mimicry. KAP3 binds via a multipartite interface with both KIF3A and KIF3B and provides a platform for cargo adaptors that occlude the beta-hairpin motif to activate motility, rather than activating motility directly. Cryo-EM structural analysis, single-molecule motility assays, cell biological assays, mutagenesis of beta-hairpin motif bioRxivpreprint Medium
2026 A KIF3B-enriched, KAP3-associated kinesin-2 assembly (distinct from canonical KIF3A/KIF3B/KAP3) preferentially associates with TRIM46, a protein required for axon initial segment organization, and the KIF3B tail domain facilitates this transport; structural differences in tail conformation accompany distinct assembly states and may underlie cargo selectivity. Biochemical fractionation, co-immunoprecipitation, cellular imaging, structural analysis of tail conformations The Journal of cell biology Medium 41910726
2025 14-3-3ε binds to the C-terminal tail domain of KIF3B in vitro, identified as a potential adaptor for kinesin-2 cargo recognition; the binding site was mapped by acceptor photobleaching-FRET and split-APEX2 assays. In vitro binding assay, acceptor photobleaching-FRET, split-APEX2 proximity assay bioRxivpreprint Low
1999 KIF3A and KIF3B subunits of kinesin-II are concentrated in photoreceptor inner segments, the outer limiting membrane, and axonemes (connecting cilium) in Xenopus and human/monkey retina, consistent with a role in transport from cell body to outer segment. Immunoblotting, immunohistochemistry/immunofluorescence on retinal sections with subunit-specific antibodies Experimental eye research Low 10548469
2017 KIF3B localizes to spindles and is enriched at the central spindle during mitosis in HeLa cells; KIF3B knockdown increases rates of multipolar division and multi-nucleation, indicating KIF3B is required for normal spindle formation and cytokinesis. siRNA knockdown, immunofluorescence during cell cycle stages, quantification of multipolar divisions and multi-nucleate cells Experimental cell research Low 28161539

Source papers

Stage 0 corpus · 40 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 1243 9865700
2010 KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding, and extracellular matrix degradation in primary macrophages. Blood 116 20505159
2014 FLA8/KIF3B phosphorylation regulates kinesin-II interaction with IFT-B to control IFT entry and turnaround. Developmental cell 91 25175706
2009 CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease. American journal of physiology. Renal physiology 51 19940036
2019 Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice. The EMBO journal 50 31746486
2013 Suppression of KIF3B expression inhibits human hepatocellular carcinoma proliferation. Digestive diseases and sciences 41 24368420
2020 Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy. American journal of human genetics 39 32386558
1999 Photoreceptor localization of the KIF3A and KIF3B subunits of the heterotrimeric microtubule motor kinesin II in vertebrate retina. Experimental eye research 37 10548469
2018 Ciliary Length Sensing Regulates IFT Entry via Changes in FLA8/KIF3B Phosphorylation to Control Ciliary Assembly. Current biology : CB 28 30057303
1996 mRNA expression of KIF1A, KIF1B, KIF2, KIF3A, KIF3B, KIF4, KIF5, and cytoplasmic dynein during axonal regeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience 28 8613797
2019 MicroRNA-127 inhibits cell proliferation via targeting Kif3b in pancreatic β cells. Aging 25 30822278
2019 MiR-127-3p targets KIF3B to inhibit the development of oral squamous cell carcinoma. European review for medical and pharmacological sciences 24 30720171
2021 Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/β-Catenin Signaling. Frontiers in oncology 19 33542902
2012 Temporal and spatial expression of KIF3B after acute spinal cord injury in adult rats. Journal of molecular neuroscience : MN 16 23093447
2011 Molecular characterization of a KIF3B-like kinesin gene in the testis of Octopus tankahkeei (Cephalopoda, Octopus). Molecular biology reports 16 22183304
2011 Association of the testis-specific TRIM/RBCC protein RNF33/TRIM60 with the cytoplasmic motor proteins KIF3A and KIF3B. Molecular and cellular biochemistry 14 21909995
2019 Research progress on KIF3B and related diseases. Annals of translational medicine 13 31700928
2017 A novel role of KIF3b in the seminoma cell cycle. Experimental cell research 12 28161539
2014 Functional Analysis of KIF3A and KIF3B during Spermiogenesis of Chinese Mitten Crab Eriocheir sinensis. PloS one 12 24870586
2020 Molecular Motor KIF3B Acts as a Key Regulator of Dendritic Architecture in Cortical Neurons. Frontiers in cellular neuroscience 11 33192305
2019 KIF3B Promotes the Proliferation of Pancreatic Cancer. Cancer biotherapy & radiopharmaceuticals 11 31157987
1999 Expressed sequence tag (EST) phenotyping of HT-29 cells: cloning of ser/thr protein kinase EMK1, kinesin KIF3B, and of transcripts that include Alu repeated elements. Biochimica et biophysica acta 11 10395937
2022 KIF3B gene silent variant leading to sperm morphology and motility defects and male infertility†. Biology of reproduction 10 34918036
2022 KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice. Developmental cell 10 36220081
2018 Analysis of the function of KIF3A and KIF3B in the spermatogenesis in Boleophthalmus pectinirostris. Fish physiology and biochemistry 10 29511984
2011 Human kidney anion exchanger 1 interacts with kinesin family member 3B (KIF3B). Biochemical and biophysical research communications 10 21871436
2020 Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer. The Kaohsiung journal of medical sciences 9 32237034
2021 Downregulated KIF3B Induced by miR-605-3p Inhibits the Progression of Colon Cancer via Inactivating Wnt/β-Catenin. Journal of oncology 8 34422048
2021 Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory. Molecular brain 8 34749771
2019 LEF-AS1 participates in occurrence of colorectal cancer through adsorbing miR-505 and promoting KIF3B expression. European review for medical and pharmacological sciences 8 31773695
2023 YY1 modulates the radiosensitivity of esophageal squamous cell carcinoma through KIF3B-mediated Hippo signaling pathway. Cell death & disease 7 38065955
2020 Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by Promoting KIF3B Expression. Technology in cancer research & treatment 7 33153390
2017 Dynamic transcription and expression patterns of KIF3A and KIF3B genes during spermiogenesis in the shrimp, Palaemon carincauda. Animal reproduction science 7 28689636
2021 Molecular characterization, dynamic transcription, and potential function of KIF3A/KIF3B during spermiogenesis in Opsariichthys bidens. Gene 6 34175396
2000 C. elegans KLP-11/OSM-3/KAP-1: orthologs of the sea urchin kinesin-II, and mouse KIF3A/KIFB/KAP3 kinesin complexes. DNA research : an international journal for rapid publication of reports on genes and genomes 6 10819327
2024 Characterization of the disease-causing mechanism of KIF3B mutations from ciliopathy patients. Frontiers in molecular biosciences 1 38665936
2026 The KIF3B/B/KAP3 tail domain specifically facilitates TRIM46 transport to the axon initial segment. The Journal of cell biology 0 41910726
2026 Attenuation of cell-cell movement of tobamoviruses by the C-terminal GPI signal peptide of arabinogalactan protein FLA8. Current biology : CB 0 42019504
2025 miR-127-3p Inhibits Cell Stemness and Docetaxel Resistance in Triple-Negative Breast Cancer by Targeting KIF3B. The Kaohsiung journal of medical sciences 0 41158092
2025 Exosomes from isobavachin-modified bone marrow mesenchymal stem cells promote osteoblast proliferation and alleviate osteoporosis by targeting the miR-127-3p/KIF3B/Wnt/β-catenin pathway. Archives of biochemistry and biophysics 0 41443290

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