Affinage

KCNN1

Small conductance calcium-activated potassium channel protein 1 · UniProt Q92952

Length
543 aa
Mass
60.0 kDa
Annotated
2026-06-10
44 papers in source corpus 16 papers cited in narrative 15 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KCNN1 encodes SK1 (KCa2.1), a small-conductance Ca2+-activated K+ channel gated by intracellular Ca2+ through calmodulin, whose activity sets neuronal afterhyperpolarization and contributes to coordinated K+ secretion in epithelia (PMID:36583726, PMID:37012681, PMID:37741322). Channel gating requires Ca2+-dependent conformational changes in both the N- and C-lobes of calmodulin engaging the channel's proximal C-terminal domain, with full-length calmodulin needed for full activation; isolated lobes bind but cannot rescue activity (PMID:36583726). Activity is additionally tuned by EGFR-mediated tyrosine phosphorylation at Tyr109 in the N-terminus, which is required for normal current density (PMID:23496660). In dorsal root ganglion neurons, KCNN1 mediates afterhyperpolarization currents that limit excitability, and its transcription is controlled by ESRRG and by SS-lncRNA acting through hnRNPM recruitment and KDM6B-dependent H3K27me3 remodeling at the Kcnn1 promoter; nerve injury downregulates KCNN1 to produce hyperexcitability and neuropathic pain, which is reversed by restoring KCNN1 (PMID:37012681, PMID:37741322, PMID:38912580). In the connecting tubule/collecting duct, SK1 couples TRPV4-mediated Ca2+ influx to BK channel activation (PMID:28274924). KCNN1 expression is further regulated transcriptionally by HDAC isoforms in atrial myocytes and post-transcriptionally by METTL3-mediated m6A methylation in ischemic myocardium, and its loss prolongs cardiomyocyte action potentials (PMID:34111326, PMID:40653133, PMID:35155564). KCNN1 also has channel-independent roles in cancer: it is overexpressed downstream of the EWS::FLI1 oncofusion in Ewing sarcoma without producing functional channel activity, and in breast cancer it binds ERLIN2 to stabilize Cyclin B1 via K63-linked ubiquitination, promoting proliferation and invasion (PMID:39487324, PMID:36230742, PMID:37831636).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1999 Medium

    Before functional study, the genomic identity of human KCNN1 was unknown; mapping the locus and exon-intron structure established the gene as a discrete entity for downstream analysis.

    Evidence Radiation hybrid mapping and gene structure analysis localizing KCNN1 to 19p13.1

    PMID:10516439

    Open questions at the time
    • No functional or expression data
    • No protein-level characterization
  2. 2001 Medium

    It was unclear how transcript diversity could tune SK1 function; characterization of extensive alternative splicing showed that variants alter the S6 span and calmodulin-binding domain, with only a minority preserving Ca2+-independent calmodulin binding.

    Evidence Genomic cloning, RT-PCR and calmodulin-binding domain assessment in mouse

    PMID:11267657

    Open questions at the time
    • Functional consequences of individual splice variants on channel gating not tested
    • Tissue distribution of variants not resolved
  3. 2013 High

    Whether KCNN1 activity is regulated beyond Ca2+/calmodulin was unknown; identification of EGFR-dependent phosphorylation at Tyr109 established a kinase input controlling channel current.

    Evidence Patch-clamp, immunoprecipitation, and Y109F mutagenesis in HEK-293 cells

    PMID:23496660

    Open questions at the time
    • Whether EGFR phosphorylates KCNN1 directly versus via an intermediate not established
    • Physiological context of this regulation untested
  4. 2017 Medium

    The role of SK1 in epithelial K+ handling was undefined; pharmacological epistasis showed SK1/3 activation by TRPV4 Ca2+ influx is required to raise [Ca2+]i sufficiently to activate BK channels.

    Evidence Apamin/TRAM-34/iberiotoxin inhibition with membrane potential and Ca2+ imaging in mCCDcl1 cells

    PMID:28274924

    Open questions at the time
    • SK1 versus SK3 contributions not separated (both apamin-sensitive)
    • In vivo relevance to renal K+ secretion not directly tested
  5. 2021 Medium

    How KCNN1 abundance is set in the heart was unknown; siRNA screening of HDAC isoforms revealed isoform-specific transcriptional control of Kcnn1 in atrial myocytes.

    Evidence Individual HDAC siRNA knockdown and tachypacing with qRT-PCR in HL-1 cells

    PMID:34111326

    Open questions at the time
    • Direct HDAC occupancy at the Kcnn1 promoter not shown
    • Functional electrophysiological consequence not measured
  6. 2021 Medium

    The contribution of SK channels to motor neuron disease was unclear; pharmacological inhibition of upregulated SK channels in C9ORF72-ALS neurons and Drosophila mitigated degeneration, placing SK activity downstream of repeat toxicity.

    Evidence SK channel inhibition with survival/motor readouts in patient-derived neurons and Drosophila

    PMID:34376242

    Open questions at the time
    • KCNN1-specific contribution among SK isoforms not isolated
    • Mechanism linking SK activity to neurodegeneration not defined
  7. 2022 Medium

    It was assumed elevated KCNN1 in cancer implies channel activity; electrophysiology in Ewing sarcoma cells found no functional KCa2.1 current despite high expression, uncoupling KCNN1 abundance from channel function.

    Evidence Patch-clamp (negative), RT-qPCR, and western blot in EwS cell lines

    PMID:36230742

    Open questions at the time
    • Reason for absent channel activity (assembly, trafficking) not determined
    • Channel-independent function not yet identified here
  8. 2022 Medium

    Post-transcriptional control of KCNN1 in ischemic heart was unknown; MeRIP and METTL3 knockdown showed m6A hypermethylation downregulates KCNN1 and affects cardiomyocyte apoptosis and angiogenesis.

    Evidence MeRIP-seq/qPCR, METTL3 siRNA, and viability/apoptosis/tube-formation assays in rat MI model and cell lines

    PMID:35155564

    Open questions at the time
    • Direct m6A reader linking methylation to KCNN1 decay not identified
    • Channel-dependence of the apoptosis/angiogenesis phenotype unresolved
  9. 2022 High

    The prevailing model held that calmodulin's C-lobe binds SK channels purely Ca2+-independently; reconstitution showed both lobes undergo Ca2+-dependent changes and full-length calmodulin is required for activation, revising the gating model.

    Evidence Inside-out patch-clamp with exogenous calmodulin, CG-MALS, and tryptophan emission spectroscopy on SK2/SKp

    PMID:36583726

    Open questions at the time
    • Experiments performed on SK2 (KCa2.2); direct extension to SK1/KCa2.1 not shown
    • Structural basis of the C-lobe Ca2+-dependent transition not resolved
  10. 2023 High

    The transcriptional basis of KCNN1 loss in neuropathic pain was unknown; SS-lncRNA was shown to control Kcnn1 via hnRNPM recruitment and KDM6B/H3K27me3 remodeling, with KCNN1 loss driving hyperexcitability and pain.

    Evidence ChIP, RIP, conditional knockout/knock-in in Mrgprd+ neurons, and patch-clamp in nerve injury models

    PMID:37012681 PMID:37741322

    Open questions at the time
    • How the two regulatory arms (hnRNPM activation vs KDM6B silencing) are coordinated not fully reconciled
    • Whether human pain involves the same axis untested
  11. 2023 Medium

    A channel-independent oncogenic role was unsuspected; KCNN1 was shown to bind ERLIN2 and stabilize Cyclin B1 via K63-linked ubiquitination, driving breast cancer proliferation and invasion.

    Evidence Co-IP, ubiquitination assays, and proliferation/migration/invasion assays with KCNN1/ERLIN2 epistasis in breast cancer cells

    PMID:37831636

    Open questions at the time
    • Single Co-IP context; direct versus indirect KCNN1–ERLIN2 binding not fully resolved
    • The ubiquitin ligase mediating K63 linkage not identified
  12. 2024 High

    Additional transcriptional regulators of KCNN1 in pain and cancer were sought; ESRRG was shown to directly activate Kcnn1 in DRG neurons, and EWS::FLI1 to drive KCNN1 via GGAA microsatellites in Ewing sarcoma affecting the cell cycle.

    Evidence ChIP for ESRRG and EWS::FLI1 promoter binding, AAV/siRNA manipulation, electrophysiology, calcium imaging, and proliferation assays

    PMID:38912580 PMID:39487324

    Open questions at the time
    • Interplay between ESRRG, SS-lncRNA and HDAC inputs at the promoter not integrated
    • In Ewing sarcoma, channel-versus-expression-dependent proliferation effect unresolved given prior negative current data
  13. 2025 Medium

    The cardiotoxicity mechanism of osimertinib and a possible neuroprotective role of KCNN1 were addressed; KCNN1 downregulation prolongs cardiomyocyte action potentials, and channel-inactive monomeric Kcnn1 overexpression extends ALS/synuclein model survival via a stress response.

    Evidence RNA-seq, optical mapping and rescue in hiPSC-cardiomyocytes/zebrafish; transgenic mouse overexpression with survival, RNAseq and immunostaining (preprint)

    PMID:40653133 PMID:bio_10.1101_2024.10.11.617887

    Open questions at the time
    • The neuroprotective stress-induction mechanism rests on a Low-confidence preprint and lacks reconstitution or mutagenesis of the proposed misfolded state
    • Whether the cardiac and neuronal effects depend on channel activity not fully separated

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the diverse transcriptional, post-transcriptional and post-translational inputs are integrated to set KCNN1 channel versus channel-independent functions in a given cell type remains unresolved.
  • No structural model of the SK1/KCa2.1 channel-calmodulin complex
  • Mechanism switching KCNN1 between channel and scaffolding (ERLIN2/Cyclin B1) roles undefined
  • No direct E3 ligase for the K63-ubiquitination of Cyclin B1 identified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 3
Localization
GO:0005886 plasma membrane 2 GO:0005829 cytosol 1
Pathway
R-HSA-112316 Neuronal System 2 R-HSA-162582 Signal Transduction 2 R-HSA-1640170 Cell Cycle 2
Partners
CALM1EGFRERLIN2HNRNPM

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 The mouse SK1 (KCNN1) gene encodes a complex pattern of alternatively spliced transcripts with at least four distinct 5'-sequence variants and eight variant C-terminal amino acid sequences. Alternative splicing can alter the putative S6 transmembrane span, modify the C-terminal cytoplasmic calmodulin-binding domain, and generate alternate predicted PDZ domain-binding sites. Only four of sixteen predicted polypeptide variants preserve the ability to bind calmodulin in a Ca2+-independent manner. Genomic cloning, RT-PCR, sequence analysis, calmodulin-binding domain assessment Biochimica et biophysica acta Medium 11267657
1999 The human KCNN1 gene (encoding SK1 small-conductance calcium-activated potassium channel) was mapped by radiation hybrid mapping to chromosome 19p13.1, and its exon-intron gene structure was defined. Radiation hybrid mapping, gene structure analysis Cytogenetics and cell genetics Medium 10516439
2013 KCNN1 (hSKCa1) channel activity is regulated by EGFR tyrosine kinase phosphorylation at Tyr109 in the N-terminus. Inhibition of EGFR kinase (by genistein, tyrphostin T25, or AG556) reduced tyrosine phosphorylation of hSKCa1 and inhibited channel current; the Y109F mutant lost the inhibitory response to EGFR inhibitors and showed dramatically reduced tyrosine phosphorylation and current density. Whole-cell patch voltage-clamp, immunoprecipitation, Western blotting, site-directed mutagenesis (Y109F) in HEK-293 cells expressing KCNN1 The Biochemical journal High 23496660
2022 Calmodulin gating of SK (KCa2.x) channels requires Ca2+-dependent conformational changes in both the N-lobe and C-lobe of calmodulin interacting with the proximal C-terminal domain (SKp) of the channel. Isolated calmodulin lobes bind SKp with high affinity but fail to rescue SK2 (KCa2.2) activity; full-length calmodulin with both lobes is required for full activation. C-lobe binding to SKp changes with Ca2+ at concentrations that activate SK2, challenging the prior model that C-lobe binding is purely Ca2+-independent. Inside-out patch-clamp recording of SK2 channels with exogenous calmodulin application; composition-gradient multi-angle light-scattering; tryptophan emission spectra for calmodulin–SKp binding eLife High 36583726
2017 SK1 (KCNN1) and SK3 (KCNN3) channels are expressed in kidney connecting tubule/cortical collecting duct (CNT/CCD) cells and are activated by TRPV4-mediated Ca2+ influx. Early activation of SK1/3 and IK1 (KCNN4) channels is required for sufficient Ca2+ entry and intracellular Ca2+ elevation needed to activate the BK channel (KCNMA1), thereby coupling TRPV4 to BK-dependent K+ secretion. Pharmacological inhibition (apamin for SK1/3, TRAM-34 for IK1, iberiotoxin for BK) with membrane potential measurement and intracellular Ca2+ imaging in mCCDcl1 cells American journal of physiology. Renal physiology Medium 28274924
2021 KCNN1 (KCa2.1) channel expression in atrial myocytes is directly regulated by histone deacetylases (HDACs). Knockdown of HDAC2, 3, 6, or 7 decreased Kcnn1 mRNA levels, while knockdown of HDAC9 enhanced Kcnn1 expression in HL-1 atrial myocytes. Tachypacing-induced downregulation of HDACs 1, 3, 4, 6, and 7 was associated with a tendency toward reduced Kcnn1 levels. siRNA knockdown of individual HDACs, tachypacing of HL-1 cells, qRT-PCR measurement of Kcnn1 mRNA Physiological reports Medium 34111326
2023 SS-lncRNA (a sensory neuron-specific lncRNA) regulates KCNN1 expression in dorsal root ganglion (DRG) neurons through two mechanisms: (1) direct binding of SS-lncRNA to the Kcnn1 promoter and recruitment of hnRNPM to activate Kcnn1 transcription; (2) in a separate study, SS-lncRNA downregulation reduces recruitment of the histone demethylase KDM6B to the Kcnn1 promoter, increasing H3K27me3 enrichment and silencing Kcnn1. Loss of KCNN1 in DRG neurons decreased total potassium currents and afterhyperpolarization currents, increased neuronal excitability, and produced neuropathic pain symptoms. ChIP, RNA immunoprecipitation, promoter binding assays, nerve injury mouse models, patch-clamp electrophysiology, conditional knockout/knock-in of SS-lncRNA in Mrgprd+ neurons Brain : a journal of neurology; Life sciences High 37012681 37741322
2024 ESRRG (estrogen-related receptor gamma), a transcription factor, directly binds the Kcnn1 promoter and activates its transcription in DRG neurons. Nerve injury reduces DRG ESRRG levels, which decreases ESRRG binding to the Kcnn1 promoter and downregulates KCNN1 expression, leading to reduced AHP currents, increased neuronal excitability, and neuropathic pain. Rescuing KCNN1 downregulation prevented these electrophysiological and pain phenotypes. ChIP (ESRRG binding to Kcnn1 promoter), AAV-mediated KCNN1 rescue and knockdown in DRG, patch-clamp electrophysiology, behavioral pain assays in CCI and L4 ligation nerve injury mouse models JCI insight High 38912580
2024 The oncofusion protein EWS::FLI1 (and EWS::ERG) directly drives KCNN1 transcription by binding GGAA microsatellites near the KCNN1 promoter, leading to SK1 channel overexpression in Ewing sarcoma cells. KCNN1 silencing slows the cell cycle; KCNN1 expression modulates membrane potential and calcium flux, affecting cell proliferation. Bioinformatics, ChIP/promoter binding assays for EWS::FLI1 at GGAA microsatellites, siRNA knockdown of KCNN1, patch-clamp electrophysiology, calcium imaging, cell proliferation assays Oncogene Medium 39487324
2022 In Ewing sarcoma (EwS) cells, KCNN1 is overexpressed and its expression is regulated by the disease-driving oncoprotein EWSR1-FLI1. However, patch-clamp experiments showed no evidence for functional KCa2.1 channel activity in EwS cells, indicating that elevated KCNN1 mRNA/protein does not translate to functional channel activity in this context. Patch-clamp electrophysiology (negative result for functional channel), RT-qPCR, western blot, gene expression profiling in EwS cell lines Cancers Medium 36230742
2023 KCNN1 interacts with ERLIN2 in breast cancer cells and enhances ERLIN2-mediated stabilization of Cyclin B1, promoting its K63-linked ubiquitination. Overexpression of KCNN1 increased Cyclin B1 protein stability and K63-dependent ubiquitination; knockdown had the opposite effect. ERLIN2 knockdown/overexpression partially rescued the effects of KCNN1 manipulation on Cyclin B1 and on cell proliferation, migration, and invasion. Co-immunoprecipitation, western blot, CCK8/clone formation/EdU/wound healing/transwell assays, transcriptomic analysis, KCNN1 overexpression and knockdown in breast cancer cells Carcinogenesis Medium 37831636
2021 Inhibition of ALS-upregulated KCNN1-3 (Drosophila SK ortholog) channels in C9ORF72-ALS patient-derived motor neurons and Drosophila motor neurons mitigates neurodegeneration and motor deficits, placing SK channel activity as a disease-modifying factor downstream of C9ORF72 repeat toxicity. Pharmacological inhibition of SK channels in C9ORF72-ALS patient-derived neurons and Drosophila motor neurons with functional (motor deficit) and cell survival readouts; genome-wide RNA analysis Molecular neurodegeneration Medium 34376242
2025 Neuronal overexpression of Kcnn1 (as a monomeric, channel-inactive subunit, because it cannot assemble without Kcnn2) extends survival in SOD1-linked ALS and A53T alpha-synuclein mouse models. The overexpressed Kcnn1 subunit is diffusely cytoplasmic (not at the plasma membrane) in motor neurons and induces a multifaceted stress response (ER stress, mitochondrial stress, integrated stress response) as assessed by RNAseq and immunostaining, suggesting that a nonassembled/potentially misfolded ER-targeted state of Kcnn1 is responsible for the neuroprotective stress induction rather than K+ channel activity. Transgenic mouse overexpression (Thy1.2-driven Kcnn1 cDNA), survival analysis, RNAseq, immunostaining for stress response markers and Kcnn1 localization bioRxivpreprint Low bio_10.1101_2024.10.11.617887
2025 Osimertinib (third-generation EGFR inhibitor) downregulates KCNN1 protein expression in cardiomyocytes as an off-target effect, leading to prolonged action potential duration and early afterdepolarizations. Modulating KCNN1 expression reversed these electrophysiological alterations, establishing KCNN1 downregulation as a mechanistic basis for osimertinib-induced arrhythmia. RNA sequencing, qRT-PCR and western blot for KCNN1, optical mapping of action potential duration in hiPSC-derived cardiomyocytes, zebrafish in vivo model, KCNN1 rescue experiments Heart rhythm Medium 40653133
2022 KCNN1 mRNA is subject to N6-methyladenosine (m6A) hypermethylation mediated by METTL3 in myocardial infarction, which is associated with downregulated KCNN1 expression. Inhibition of METTL3 reduced m6A methylation of Kcnn1 mRNA and restored its expression. Functional validation showed that Kcnn1 expression influences apoptosis and angiogenesis in H9c2 cardiomyocytes and HUVECs under hypoxic conditions. MeRIP-seq, MeRIP-qRT-PCR, siRNA knockdown of METTL3, cell viability (CCK-8, EdU), tube formation assay, flow cytometry/TUNEL for apoptosis in rat MI model and cell lines Frontiers in molecular biosciences Medium 35155564

Source papers

Stage 0 corpus · 44 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. The Journal of biological chemistry 163 15347667
2022 Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction. Nature neuroscience 86 36171425
2016 Genome-wide DNA hydroxymethylation identifies potassium channels in the nucleus accumbens as discriminators of methamphetamine addiction and abstinence. Molecular psychiatry 66 27046646
2019 Expression Profiling of Calcium Channels and Calcium-Activated Potassium Channels in Colorectal Cancer. Cancers 52 31010205
2015 KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 52 25662840
2001 Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1. Biochimica et biophysica acta 49 11267657
2016 Regulation of SCN3B/scn3b by Interleukin 2 (IL-2): IL-2 modulates SCN3B/scn3b transcript expression and increases sodium current in myocardial cells. BMC cardiovascular disorders 45 26728597
2010 Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats. Brain research 39 20553876
2012 Protective Roles for Potassium SK/K(Ca)2 Channels in Microglia and Neurons. Frontiers in pharmacology 37 23189056
2021 Cardiac small-conductance calcium-activated potassium channels in health and disease. Pflugers Archiv : European journal of physiology 36 33624131
2023 A sensory neuron-specific long non-coding RNA reduces neuropathic pain by rescuing KCNN1 expression. Brain : a journal of neurology 32 37012681
2021 Small Conductance Ca2 +-Activated K+ (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue. Frontiers in physiology 31 33868017
2001 Genomic organization and promoter analysis of human KCNN3 gene. Journal of human genetics 28 11501944
2021 SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis. Molecular neurodegeneration 25 34376242
2022 Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels. Acta pharmacologica Sinica 23 35715699
2019 A Single Prior Injection of Methamphetamine Enhances Methamphetamine Self-Administration (SA) and Blocks SA-Induced Changes in DNA Methylation and mRNA Expression of Potassium Channels in the Rat Nucleus Accumbens. Molecular neurobiology 22 31758400
2006 Expression of intermediate-conductance, Ca2+-activated K+ channel (KCNN4) in H441 human distal airway epithelial cells. American journal of physiology. Lung cellular and molecular physiology 18 16766578
2023 Small-conductance calcium-activated potassium channels in the heart: expression, regulation and pathological implications. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 17 37122223
2014 Histological and Biochemical Comparisons between Right Atrium and Left Atrium in Patients with Mitral Valvular Atrial Fibrillation. Korean circulation journal 17 25089135
2022 Peripheral Ion Channel Genes Screening in Painful Small Fiber Neuropathy. International journal of molecular sciences 16 36430572
1999 Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1). Cytogenetics and cell genetics 16 10516439
2011 Characteristics of Kcnn4 channels in the apical membranes of an intestinal epithelial cell line. American journal of physiology. Gastrointestinal and liver physiology 15 21868633
2017 Dynamic coupling between TRPV4 and Ca2+-activated SK1/3 and IK1 K+ channels plays a critical role in regulating the K+-secretory BK channel in kidney collecting duct cells. American journal of physiology. Renal physiology 14 28274924
2021 Trigger-Specific Remodeling of KCa2 Potassium Channels in Models of Atrial Fibrillation. Pharmacogenomics and personalized medicine 12 34045886
2021 Differential regulation of KCa 2.1 (KCNN1) K+ channel expression by histone deacetylases in atrial fibrillation with concomitant heart failure. Physiological reports 12 34111326
2022 Validated Impacts of N6-Methyladenosine Methylated mRNAs on Apoptosis and Angiogenesis in Myocardial Infarction Based on MeRIP-Seq Analysis. Frontiers in molecular biosciences 10 35155564
2013 EGFR tyrosine kinase regulates human small-conductance Ca2+-activated K+ (hSKCa1) channels expressed in HEK-293 cells. The Biochemical journal 10 23496660
2023 KCa 2.2 (KCNN2): A physiologically and therapeutically important potassium channel. Journal of neuroscience research 9 37466411
2014 The large-conductance calcium-activated potassium channel holds the key to the conundrum of familial hypokalemic periodic paralysis. Korean journal of pediatrics 9 25379045
2022 Relevance of Abnormal KCNN1 Expression and Osmotic Hypersensitivity in Ewing Sarcoma. Cancers 7 36230742
2021 Molecular basis of ventricular arrhythmogenicity in a Pgc-1α deficient murine model. Molecular genetics and metabolism reports 7 33898262
2023 PIMT Controls Insulin Synthesis and Secretion through PDX1. International journal of molecular sciences 6 37175791
2018 Atrium-specific ion channels in the zebrafish-A role of IKACh in atrial repolarization. Acta physiologica (Oxford, England) 6 29412518
2017 Control of anterior pituitary cell excitability by calcium-activated potassium channels. Molecular and cellular endocrinology 6 28596131
2024 Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling. Oncogene 5 39487324
2022 Calcium dependence of both lobes of calmodulin is involved in binding to a cytoplasmic domain of SK channels. eLife 5 36583726
2023 Sensory neuron-specific long noncoding RNA in small non-peptidergic dorsal root ganglion neurons selectively impairs nerve injury-induced mechanical hypersensitivity. Life sciences 4 37741322
2025 Escalated oxycodone self-administration is associated with expression of voltage gated and calcium activated potassium channels in the mesocorticolimbic system in rats. Frontiers in pharmacology 3 40860865
2024 ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain. JCI insight 3 38912580
2023 KCNN1 promotes proliferation and metastasis of breast cancer via ERLIN2-mediated stabilization and K63-dependent ubiquitination of Cyclin B1. Carcinogenesis 3 37831636
2023 Inhibition of SK Channels in VTA Affects Dopaminergic Neurons to Improve the Depression-Like Behaviors of Post-Stroke Depression Rats. Neuropsychiatric disease and treatment 3 37840624
2025 Atrial arrhythmogenesis and electrophysiological remodeling in hypokalaemic metabolic syndrome: the role of apamin-sensitive SK channels. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 1 40882027
2025 Targeting Ca2+-activated K+ channels in glioma. Biochimica et biophysica acta. Molecular basis of disease 0 40484048
2025 Osimertinib induces prolongation of action potential duration via downregulation of KCNN1 expression: Exploring the potential mechanisms of arrhythmia. Heart rhythm 0 40653133

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