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Showing MAPK8IP1 — JIP1 is a alias.

MAPK8IP1

C-Jun-amino-terminal kinase-interacting protein 1 · UniProt Q9UQF2

Length
711 aa
Mass
77.5 kDa
Annotated
2026-06-10
100 papers in source corpus 42 papers cited in narrative 42 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MAPK8IP1 (JIP1/IB1) is an intrinsically disordered scaffold protein that organizes the JNK MAP kinase cascade and, independently, governs the direction of microtubule-based axonal cargo transport (PMID:12640031, PMID:23897889). It assembles the MLK3/DLK–MKK7–JNK module on a single platform: JNK docking is mediated by a canonical D-motif together with a non-canonical F-motif that together form a bipartite binding mode resolved by crystallography and NMR (PMID:15141161, PMID:39999166), while regulated SH3-domain homodimerization—and heterodimerization with JIP2—is structurally required for efficient pathway activation (PMID:16456539, PMID:39013462). Activation of the assembled module is gated by phosphorylation of JIP1 itself: JNK phosphorylation of Thr103 triggers DLK dissociation and module firing (PMID:12756254), whereas tonic Src-family tyrosine phosphorylation maintains the complex in an inactive, DLK-bound state (PMID:17242197). Genetically, JIP1 is essential for stress-induced JNK activation in vivo, and a knock-in mutation that selectively blocks JIP1-scaffolded JNK signaling protects mice from obesity-induced insulin resistance and lowers the threshold for hippocampal LTP and spatial memory (PMID:11562351, PMID:20679483, PMID:29540552). In its second major role JIP1 links cargo to motors, binding kinesin heavy and light chains to relieve kinesin-1 autoinhibition while dynactin p150Glued competes for binding; JNK-dependent phosphorylation of Ser421 acts as a directional switch between anterograde kinesin and retrograde dynein transport of APP, autophagosomes, and TrkB (PMID:23897889, PMID:24914561, PMID:28638935). JIP1 connects this transport machinery to specific cargoes including the APP intracellular domain, LC3-marked autophagosomes, and Rab10 vesicles (PMID:11724784, PMID:24914561, PMID:24478353). As an anti-apoptotic regulator in pancreatic beta-cells and neurons, JIP1 sequesters and limits JNK-driven c-Jun phosphorylation, and its loss or caspase-3 cleavage de-represses JNK activation and apoptosis (PMID:10700186, PMID:12640031, PMID:21237154). JIP1 also functions in the nucleus as a DNA-binding transactivator of the GLUT2 gene, with its tissue-restricted expression set by REST-mediated repression (PMID:9442013, PMID:11585908).

Mechanistic history

Synthesis pass · year-by-year structured walk · 20 steps
  1. 1998 High

    Established that the rat ortholog IB1 is not only a cytoplasmic protein but a nuclear DNA-binding transactivator, revealing a transcriptional role in beta-cells before its scaffold function was known.

    Evidence expression cloning, in vitro DNA binding, transactivation reporter and GAL4 domain mapping in insulin-secreting cells

    PMID:9442013

    Open questions at the time
    • Direct DNA binding by the human protein in a physiological chromatin context not shown
    • Relationship between nuclear transcriptional and cytoplasmic scaffold functions unresolved
  2. 2000 High

    Defined JIP1/IB1 as an anti-apoptotic regulator that buffers JNK signaling in beta-cells, linking its abundance to control of c-Jun/ATF2 phosphorylation and survival.

    Evidence antisense knockdown and viral overexpression in beta-cell lines, kinase and apoptosis assays, functional 559N mutation

    PMID:10700186

    Open questions at the time
    • Whether sequestration vs. assembly explains the dose-dependent effect not distinguished
    • In vivo relevance addressed only later
  3. 2001 High

    Genetic knockout demonstrated JIP1 is required for stress-induced JNK activation in vivo, moving the scaffold from a biochemical concept to a physiological requirement.

    Evidence Jip1 knockout mice, neuronal live-imaging, brain JNK activation assays under excitotoxic/anoxic stress

    PMID:11562351

    Open questions at the time
    • Which upstream stimuli specifically require JIP1 not fully mapped
    • Mechanism of neurite-to-soma redistribution unexplained
  4. 2001 High

    Connected JIP1 to APP biology and to upstream MLKs, identifying both a cargo (APP intracellular domain) and a kinase input (LZK) for the scaffold.

    Evidence yeast two-hybrid, in vitro binding, FRET, brain Co-IP for APP; Co-IP and kinase assay for LZK/MKK7

    PMID:11724784 PMID:11726277

    Open questions at the time
    • Functional consequence of APP–JIP1 binding for APP processing not established here
    • LZK study Medium-confidence, single lab
  5. 2001 High

    Explained the tissue-restricted expression of MAPK8IP1 through REST-mediated, HDAC-dependent repression at an NRSE element.

    Evidence luciferase reporter, EMSA, NRSE mutagenesis and trichostatin A treatment

    PMID:11585908

    Open questions at the time
    • Other transcriptional inputs to the IB1 promoter unaddressed
  6. 2003 High

    Identified Thr103 phosphorylation by JNK as the specific switch driving DLK dissociation and module activation, and confirmed the beta-cell anti-apoptotic scaffold function via caspase-3.

    Evidence site-specific mutagenesis, in vitro kinase and DLK oligomerization assays; adenoviral over/under-expression and haploinsufficient mice with caspase-3 readout

    PMID:12640031 PMID:12756254

    Open questions at the time
    • How Thr103 phosphorylation structurally weakens DLK affinity not resolved
    • Other phosphosite contributions not excluded
  7. 2004 High

    Provided the atomic basis of JIP1's selectivity for JNK1 and revealed an allosteric inhibition mechanism whereby peptide binding distorts the ATP cleft.

    Evidence X-ray crystallography of JNK1–pepJIP1 binary and ternary complexes

    PMID:15141161

    Open questions at the time
    • Captures only the D-motif; bipartite engagement defined only later
    • Full-length disordered context not in the structure
  8. 2004 High

    Extended the JIP1-dependent JNK requirement to metabolic disease, showing JIP1 is needed for obesity-induced JNK activation and IRS-1 Ser307 phosphorylation underlying insulin resistance.

    Evidence Jip1 knockout mice on high-fat diet, adipose JNK and IRS-1 phosphorylation assays

    PMID:15314024

    Open questions at the time
    • Tissue-specific contribution (adipose vs. liver vs. muscle) not dissected here
  9. 2005 Medium

    Uncovered regulatory crosstalk in which JIP1 sequesters and inhibits Akt1, with JNK2 phosphorylation releasing Akt1 to form a negative feedback loop.

    Evidence Co-IP, kinase assays, siRNA of JIP1/SEK1/Akt1 during glucose deprivation

    PMID:15998799

    Open questions at the time
    • Single lab; reciprocal validation limited
    • Physiological setting beyond glucose deprivation unclear
  10. 2006 High

    Defined SH3–SH3 homodimerization as a functional requirement, structurally explaining how dimerization occludes the PxxP ligand site and tunes basal JNK activity and beta-cell function.

    Evidence X-ray crystallography, dimer-disrupting mutagenesis, JNK/GLUT2/insulin-secretion readouts; plus viral B1R kinase binding study

    PMID:16456539 PMID:16840345

    Open questions at the time
    • How dimerization status is dynamically regulated in cells not established
    • B1R study Medium-confidence, viral context
  11. 2007 Medium

    Established tonic inhibitory control of the module: Src-family tyrosine phosphorylation increases JIP1 affinity for DLK and locks the complex inactive, and IB1 stabilizes short JNK splice variants against degradation.

    Evidence Co-IP, in vitro kinase and tyrosine-phosphorylation assays; inducible IB1 expression and JNK protein stability assays

    PMID:17242197 PMID:17669625

    Open questions at the time
    • Specific Src-family member and target tyrosines partially defined
    • Single lab for each finding
  12. 2008 High

    Linked JIP1 to axon specification and growth, identifying c-Abl as a kinase whose phosphorylation of JIP1 is required for kinesin-dependent axonal outgrowth.

    Evidence live imaging, knockdown/rescue, c-Abl Co-IP and phosphosite mutagenesis in cortical neurons; plus VRK2 signalosome study

    PMID:18261906 PMID:18286207

    Open questions at the time
    • c-Abl phosphosite identity and its effect on motor binding incompletely mapped
    • VRK2 study Medium-confidence
  13. 2010 High

    A knock-in mouse isolating JIP1 scaffold function (T103A) proved that JIP1-mediated JNK activation is causally required for obesity-induced insulin resistance.

    Evidence germ-line Jip1 T103A knock-in mice, high-fat diet, JNK and metabolic phenotyping

    PMID:20679483

    Open questions at the time
    • Cell-type origin of the protective metabolic effect not localized
  14. 2013 High

    Resolved JIP1 as a bidirectional transport switch, showing it relieves kinesin-1 autoinhibition while p150Glued competes for binding and Ser421 phosphorylation sets transport direction for APP.

    Evidence single-molecule motility, competitive binding, live APP imaging, S421A/S421D phosphomutants in neurons

    PMID:23897889

    Open questions at the time
    • Kinase/phosphatase that toggle S421 in distinct compartments only partly identified
  15. 2013 Medium

    Broadened the JIP1 scaffold and motor roles across pathways and cargoes: RALA/RLF-driven ROS-induced FOXO activation, POSH-dependent TCR/JNK1 signaling in CD8 T cells, and PTB-domain (F687)-mediated JIP3/kinesin-1 ternary complex assembly.

    Evidence Co-IP, RNAi, FOXO/transcription-factor reporters, C. elegans genetics; proteomics and F687 mutagenesis

    PMID:23496950 PMID:23770673 PMID:23963642

    Open questions at the time
    • Each pathway shown by single labs
    • Direct vs. indirect assembly within these networks not fully separated
  16. 2014 High

    Defined cargo-specific transport mechanisms: a LIR motif binds LC3 to drive retrograde autophagosome transport (with MKP1 keeping S421 dephosphorylated), and JIP1 links GTP-Rab10 to KLC for anterograde precursor-vesicle transport; central KLC1-binding regions tune APP transport frequency and velocity.

    Evidence direct binding/competition assays, phosphomutant rescue, live imaging of autophagosomes, PPVs and APP; domain mapping and KLC1 phosphomutants

    PMID:24478353 PMID:24914561 PMID:25165140

    Open questions at the time
    • How a single scaffold coordinates competing cargo signals in one axon not integrated
    • Rab10 and KLC1 findings Medium-confidence single-lab
  17. 2017 Medium

    Showed JIP1 cooperation and abundance control of transport: JIP1/JIP3 jointly relieve kinesin-1 autoinhibition for TrkB/BDNF retrograde signaling, and HDAC-inhibitor-induced JIP1 drives KIF5A-dependent cargo transport independent of JNK.

    Evidence JIP1 knockout, nerve ligation, motor-binding and live imaging; HDAC inhibition, knockdown and JIP1:KIF5A complex Co-IP in cardiomyocytes

    PMID:28638935 PMID:28886967

    Open questions at the time
    • Quantitative contribution of JIP1 vs JIP3 not separated
    • Single labs
  18. 2018 High

    Provided biophysical and physiological resolution of transport regulation: KLC1-TPR binding residues and competition with W-acidic cargoes were mapped, KLC1 Thr466 phosphorylation (rising with brain age) impairs fast APP transport, and a JNK-blocking knock-in revealed JIP1-JNK as a negative regulator of synaptic plasticity and memory.

    Evidence ITC and competition assays, KLC1 T466E phosphomutant transport imaging, aged-brain biochemistry; two independent Jip1 knock-in mouse lines with electrophysiology and behavior

    PMID:29093025 PMID:29540552 PMID:30026235

    Open questions at the time
    • Causal link between age-related KLC1 phosphorylation and disease not established
    • Transport-defect contribution to the memory phenotype not separated from JNK signaling
  19. 2022 Medium

    Defined Cdk5-driven control of axon outgrowth through JIP1 Thr205 phosphorylation, which amplifies Itch-mediated Notch1 degradation, and placed JNK3/JIP1/β-arrestin2/PSD95 complexes at postsynaptic densities.

    Evidence interactome screen, phosphorylation assays, phosphomimic rescue in KO neurons, Notch1 ubiquitination assay; super-resolution microscopy and Co-IP

    PMID:35456931 PMID:35581583

    Open questions at the time
    • Single-lab findings
    • Interplay between Cdk5-Thr205, c-Abl, and Src inputs on the same scaffold unresolved
  20. 2025 High

    Refined the JIP1–JNK interface, showing the disordered tail engages JNK1 bipartitely through both the canonical D-motif and a newly identified F-motif.

    Evidence NMR of the JIP1 disordered tail and 2.35 Å crystal structure of the JIP1–JNK1 complex; with JIP1–JIP2 SH3 heterodimer structure (2024)

    PMID:39013462 PMID:39999166

    Open questions at the time
    • Functional consequence of F-motif loss in vivo not tested
    • How bipartite docking integrates with allosteric ATP-cleft distortion not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single intrinsically disordered scaffold integrates competing inputs—nuclear transcription, JNK module assembly/inhibition, and bidirectional motor switching for distinct cargoes—within one cell remains unresolved.
  • No unified model connecting phosphocode (Thr103, Thr205, Ser421, tyrosines) to functional output
  • Stoichiometry and spatial segregation of JIP1 complexes in vivo unknown
  • No timeline disease-gene mutation linking MAPK8IP1 to a Mendelian disorder

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 4 GO:0060090 molecular adaptor activity 4 GO:0098772 molecular function regulator activity 3 GO:0140313 molecular sequestering activity 2 GO:0003677 DNA binding 1 GO:0140110 transcription regulator activity 1
Localization
GO:0005829 cytosol 3 GO:0005856 cytoskeleton 3 GO:0005634 nucleus 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-9609507 Protein localization 4 R-HSA-1266738 Developmental Biology 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-74160 Gene expression (Transcription) 2 R-HSA-9612973 Autophagy 2
Partners
APPKIF5 (KINESIN HEAVY CHAIN)KLC1MAP1LC3 (LC3)MAP2K7 (MKK7)MAP3K12 (DLK)MAPK8 (JNK1)RAB10
Complex memberships
JIP1–JIP2 SH3 heterodimerJIP1–kinesin-1 (KHC/KLC) motor complexMLK3/DLK–MKK7–JNK signaling modulePOSH/JIP1 scaffold complex

Evidence

Reading pass · 42 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 Crystal structure of human JNK1 complexed with the JIP1 peptide (pepJIP1) revealed that Pro157, Leu160, and Leu162 of pepJIP1 make van der Waals contacts and Arg156 of pepJIP1 forms a hydrogen bond with Glu329 of JNK1, conferring selectivity for JNK1 over other MAPKs. Peptide binding induces a hinge motion between N- and C-terminal domains of JNK1, distorting the ATP-binding cleft and reducing ATP affinity (allosteric inhibition mechanism). X-ray crystallography of JNK1–pepJIP1 binary complex and JNK1–pepJIP1–SP600125 ternary complex The EMBO journal High 15141161
2001 JIP1 scaffold protein is required for stress-induced JNK activation in vivo: JIP1-knockout mice are refractory to JNK activation caused by excitotoxic and anoxic stress. Under stress, JIP1 redistributes from neurites to the soma together with activated JNK and phosphorylated c-Jun. Homologous recombination gene knockout in mice; live-imaging of JIP1 localization in primary hippocampal neurons; JNK activation assays in brain Genes & development High 11562351
2013 JIP1 coordinates bidirectional APP axonal transport by switching between anterograde (kinesin-1) and retrograde (dynein) motor complexes. JIP1 binds kinesin heavy chain (KHC) directly and relieves KHC autoinhibition; dynactin subunit p150Glued competes with KHC for JIP1 binding and inhibits KHC activation. JNK-dependent phosphorylation of JIP1 at Ser421 acts as a molecular switch: phosphorylation promotes retrograde while dephosphorylation promotes anterograde transport. Single-molecule motility assays; co-immunoprecipitation; live imaging of APP transport in neurons; phosphomutant (S421A/S421D) analysis The Journal of cell biology High 23897889
2014 JIP1 binds directly to the autophagosome adaptor LC3 via a conserved LIR motif. This interaction is required for retrograde autophagosome transport initiation and sustenance in axons. LC3 binding to JIP1 competitively disrupts JIP1-mediated kinesin-1 activation, and dephosphorylated JIP1-S421 (maintained by autophagosome-associated MKP1 phosphatase) favors retrograde transport, ensuring robust retrograde autophagosomal movement. Direct binding assay; live-cell imaging of autophagosome transport; JIP1 depletion and rescue with phosphomutants (S421A, S421D); competitive binding assays Developmental cell High 24914561
2001 JIP1 binds the cytoplasmic intracellular domain (AID) of APP. This interaction was confirmed in vitro, in vivo by FRET, and in mouse brain lysates, linking APP processing by γ-secretase to JNK stress-kinase signaling pathways. Yeast two-hybrid; in vitro binding assay; FRET in cells; co-immunoprecipitation from mouse brain The Journal of biological chemistry High 11724784
2003 JNK binding to JIP1 is necessary for stimulus-induced dissociation of DLK from JIP1, DLK oligomerization, and JNK module activation. JNK phosphorylates JIP1 on Thr-103; this phosphorylation is specifically required for DLK dissociation and subsequent module activation, not other JNK-dependent phosphorylation sites on JIP1. Mutagenesis of JIP1 phosphorylation sites; in vitro kinase assays; co-immunoprecipitation; DLK oligomerization assays The Journal of biological chemistry High 12756254
1998 IB1 (rat homolog of JIP-1) is a DNA-binding nuclear protein expressed in pancreatic beta-cells that binds the GTII cis-regulatory element of the GLUT2 promoter in vitro and transactivates the GLUT2 gene. An activation domain was mapped to the first 280 amino acids. IB1 localizes to both cytoplasm and nucleus of insulin-secreting cells. Expression cloning; in vitro DNA binding assay; transactivation reporter assay; immunocytochemistry; GAL4 domain mapping The Journal of biological chemistry High 9442013
2000 IB1/JIP-1 overexpression in insulin-producing cells prevents JNK-mediated phosphorylation of c-Jun, ATF2, and Elk1 and decreases IL-1β- and ΔMEKK1-induced apoptosis. Reducing IB1 content (antisense RNA) increases c-Jun phosphorylation and apoptosis. A missense mutation (559N) abolishes IB1's ability to counteract JNK-pathway inhibition of insulin transcription and to prevent MEKK1-induced apoptosis. Antisense RNA knockdown in beta-cell lines; overexpression with viral gene transfer; kinase activity assays; apoptosis measurement; functional mutation analysis (559N) Nature genetics High 10700186
2004 JIP1 scaffold protein is essential for JNK activation in adipose tissue during obesity. JIP1 deficiency prevents JNK-dependent phosphorylation of IRS-1 on Ser307, thereby protecting against obesity-induced insulin resistance. Jip1 gene knockout mice fed high-fat diet; JNK activity assays in adipose tissue; IRS-1 phosphorylation assays Genes & development High 15314024
2009 Hyperphosphorylated Tau interacts with JIP1 under pathological conditions, sequestering JIP1 in the cell body and impairing JIP1 transport into axons. Tau competes with kinesin light chain for JIP1 binding. This pathological Tau/JIP1 interaction requires Tau phosphorylation. Co-immunoprecipitation from K3 (K369I mutant Tau) transgenic mouse brain and AD human brain; immunofluorescence; primary neuronal culture transfection The Journal of biological chemistry Medium 19491104
2005 Drosophila APLIP1 (JIP-1 homolog) genetically interacts with kinesin-1 and dynein: Aplip1 mutation causes reduced anterograde and retrograde vesicle transport and reduced retrograde mitochondria transport, with synthetic phenotypes when combined with Dynein heavy chain heterozygous mutation, indicating APLIP1 is part of motor-cargo linkage complexes for both motors. Genetic screen; Aplip1 mutant analysis (larval paralysis, axonal swelling); quantitative axonal transport assays; double-mutant epistasis Current biology : CB High 16332540
2008 JIP1 localizes specifically to a single neurite before polarization and accumulates in the emerging axon after specification in cortical neurons. JIP1 is required for normal axonal development and promotes axonal growth dependent on kinesin-1 binding and via a newly discovered interaction with c-Abl tyrosine kinase. JIP1 is phosphorylated by c-Abl, and mutation of the c-Abl phosphorylation site on JIP1 abrogates its ability to promote axonal growth. Live-cell imaging; JIP1 knockdown and rescue; co-immunoprecipitation with c-Abl; phosphorylation-site mutagenesis; axon length quantification Current biology : CB High 18261906
2014 JIP1 interacts with the GTP-locked active form of Rab10 and directly connects Rab10 to kinesin-1 light chain (KLC), forming a kinesin-1/JIP1/Rab10 complex required for anterograde transport of plasmalemmal precursor vesicles (PPVs) during axonal growth and neuronal polarization in vitro and in vivo. Co-immunoprecipitation; JIP1 knockdown; live imaging of PPV transport; in vivo neuronal polarization assay in rat cortex The Journal of neuroscience Medium 24478353
2006 IB1/JIP1 homodimerizes through a unique SH3–SH3 interaction. X-ray crystallography showed the dimer interface covers the region normally engaged in PxxP-mediated ligand recognition. Point mutations disrupting dimerization reduce IB1-dependent basal JNK activity and impair GLUT2 expression and glucose-dependent insulin secretion in beta-cells. X-ray crystallography; site-directed mutagenesis; JNK activity assay; GLUT2 expression; glucose-stimulated insulin secretion The EMBO journal High 16456539
2001 LZK (a mixed lineage kinase) binds the C-terminal region of JIP-1 through its kinase catalytic domain, and LZK-induced JNK activation is markedly enhanced when co-expressed with JIP-1. LZK directly phosphorylates and activates MKK7. Co-immunoprecipitation; in vitro kinase assay; co-transfection/overexpression JNK activity assay Journal of biochemistry Medium 11726277
2005 Akt1 interacts with JIP1 and its catalytic activity is inhibited when bound. JNK2-mediated phosphorylation of JIP1 causes dissociation of Akt1 from JIP1, restoring Akt1 activity. Dissociated Akt1 then binds SEK1 and inhibits it by phosphorylation on Ser-80, forming a negative regulatory feedback loop during glucose deprivation. Co-immunoprecipitation; kinase activity assays; siRNA knockdown of JIP1, SEK1, and Akt1; phosphorylation assays The Journal of cell biology Medium 15998799
2008 VRK2 stably interacts with JIP1, TAK1, and MKK7 (but not JNK), and its binding to the JIP1 signalosome prevents JNK association, reducing JNK phosphorylation and AP-1-dependent transcription in response to IL-1β. Knockdown of JIP1 eliminates the AP-1 transcriptional response to IL-1β. Co-immunoprecipitation; shRNA and siRNA knockdown; AP-1 reporter assays; JNK phosphorylation assays PloS one Medium 18286207
2007 Src family kinases directly bind and tyrosine-phosphorylate JIP1 under basal conditions, increasing JIP1 affinity for DLK and maintaining the JIP-JNK module in a catalytically inactive state. Co-immunoprecipitation; in vitro kinase assay; tyrosine phosphorylation detection; multiple cell systems Molecular and cellular biology Medium 17242197
2003 JIP1 serves as a scaffold for MLK3, MKK7, and JNK in beta-cells; cytokine-induced reduction of IB1/JIP-1 content increases JNK activity and apoptosis rate. Overproducing IB1/JIP-1 prevents cytokine-induced apoptosis by inhibiting caspase-3 cleavage. Haploinsufficient mice (one disrupted Jip1 allele) show increased JNK activity and basal apoptosis in isolated pancreatic islets. Adenoviral gene transfer (overexpression and knockdown); JNK activity assay; caspase-3 cleavage assay; apoptosis measurement; heterozygous knockout mice Journal of cell science High 12640031
2001 The transcriptional repressor REST controls the tissue-specific expression of MAPK8IP1/IB1. REST binds the NRSE element in the IB1 promoter (confirmed by EMSA), represses IB1 transcription in non-beta, non-neuronal cells, and this repression requires histone deacetylase activity (abolished by trichostatin A). Luciferase reporter assay; EMSA (mobility shift assay); REST transfection; NRSE mutagenesis; trichostatin A treatment Molecular and cellular biology High 11585908
2010 JIP1-mediated JNK activation (via Thr103 phosphorylation of JIP1) is required for obesity-induced insulin resistance. A Jip1 point mutation (T103A) that selectively blocks JIP1-mediated JNK activation severely impairs high-fat-diet-induced JNK activation and protects mice from obesity-induced insulin resistance. Germ-line Jip1 T103A knock-in mice; high-fat diet challenge; JNK activation assay; insulin tolerance/glucose tolerance tests Molecular and cellular biology High 20679483
2011 JIP1 is cleaved by caspase-3 at two sites during TRAIL- and staurosporine-induced apoptosis, leading to disassembly of the JIP1/JNK scaffold complex and subsequent JNK inactivation. Inhibition of caspase-3-mediated JIP1 cleavage sustains JNK activation. Maximal JNK activation correlates with intact JIP1, while JIP1 cleavage correlates with JNK inactivation. Cell apoptosis assays (TRAIL, staurosporine); Western blot detection of caspase-3-mediated JIP1 cleavage; caspase-3 inhibitor (DEVD.fmk); co-immunoprecipitation of JIP1/JNK complex Experimental cell research Medium 21237154
2013 RALA GTPase, activated by RLF (in complex with JIP1 and JNK), promotes assembly and activation of MLK3, MKK4, and JNK onto the JIP1 scaffold following oxidative stress. This pathway mediates ROS-induced JNK-dependent FOXO activation and is conserved in C. elegans (ral-1 and jip-1 depletion both impair FOXO/DAF16 nuclear translocation). Co-immunoprecipitation; siRNA/RNAi knockdown; FOXO reporter assays; C. elegans genetic analysis The Journal of biological chemistry Medium 23770673
2012 IL-1β stimulates Lys-63-linked ubiquitination of MLK3 by TRAF6 via a conserved pentapeptide motif in the MLK3 catalytic domain. This ubiquitination is required for dissociation of monomeric MLK3 from the JIP1/IB1 scaffold, enabling MLK3 dimerization, autophosphorylation, and activation. Preventing MLK3 ubiquitination (or adding A20 deubiquitinase) blocks MLK3 activation and BAX translocation in cytokine-stimulated beta-cells. Ubiquitination assays; co-immunoprecipitation; MLK3 dimerization assays; BAX translocation assay; A20 expression; mutagenesis of TRAF6-binding motif The Journal of biological chemistry High 23172226
2006 Vaccinia virus B1R kinase binds the central region of JIP1 (independent of B1R kinase activity), increasing the amount of MKK7 and TAK1 bound to JIP1 (more stable or higher affinity), increasing JNK phosphorylation in the complex, and thereby enhancing c-Jun transcription factor activity. Co-immunoprecipitation; kinase activity assays; reporter assays for c-Jun activity; kinase-dead B1R mutant Journal of virology Medium 16840345
2005 SHIP2 interacts with JIP1 (confirmed in overexpression and native cells), positively modulates MLK3/JIP1-mediated JNK1 activation, and increases tyrosine phosphorylation of JIP1. This SHIP2 effect on JNK activity and JIP1 tyrosine phosphorylation is independent of SHIP2 phosphoinositide 5-phosphatase activity and is prevented by Src/Abl kinase inhibitors (PP2, Glivec). Co-immunoprecipitation in overexpression and endogenous systems; JNK activity assay; phosphatase-dead SHIP2 mutant; kinase inhibitor treatment Cellular signalling Medium 18486448
2017 JIP1 and JIP3 cooperate to relieve kinesin-1 autoinhibition: JIP1 binds KHC (kinesin heavy chain) and KLC, while JIP3 binds KLC. Together they mediate anterograde axonal transport of TrkB. This cooperative mechanism is required for BDNF-induced TrkB retrograde signaling. JIP1 knockout mice; sciatic nerve ligation analysis; live imaging; microtubule-binding assays; microfluidic chamber assays Cellular and molecular life sciences : CMLS Medium 28638935
2014 JIP1b has two novel regions in its central domain that interact with the coiled-coil domain of KLC1 (in addition to the conventional C-terminal 11-amino acid/C11 region that binds KLC1-TPR). The novel regions are required for high-frequency APP anterograde transport, while the C11 domain (regulated by the second novel region) is required for fast-velocity APP transport. KLC1 Thr466 phosphorylation abolishes C11/KLC1-TPR interaction and fast-velocity transport. Quantitative live-imaging of APP transport in JIP1-deficient neurons; truncation/domain mapping; co-immunoprecipitation; phosphomutant analysis Molecular biology of the cell Medium 25165140 29093025
2010 JIP1 binds RBP-Jκ (a Notch1 transcriptional effector) via the C-terminal SH3 domain of JIP1 interacting with the proline-rich domain of RBP-Jκ, causing cytoplasmic retention of RBP-Jκ and suppressing Notch1 activity. Conversely, RBP-Jκ inhibits JIP1-mediated JNK1 activation and cell death. Co-immunoprecipitation; subcellular fractionation; Notch1 reporter assay; domain-mapping by deletion mutants Cell death and differentiation Medium 20508646
2007 IB1/JIP1 selectively stabilizes the short splice variants of JNK (not the long variants) against proteasomal degradation, increasing their steady-state protein levels. This represents a mechanism by which IB1 regulates the JNK pathway independent of direct kinase cascade assembly. Tetracycline-inducible IB1 expression in HEK293 cells; Western blot for JNK splice variants across tissues; protein stability assays Cellular signalling Medium 17669625
2018 JIP1 mediates anterograde transport of APP by binding to both KHC and KLC of kinesin-1. Phosphorylation of KLC1 at Thr466 abolishes the JIP1b C11/KLC1-TPR interaction and the enhanced fast velocity of APP transport; this KLC1 phosphorylation increases in aged brains, suggesting age-related impairment of APP transport. In vitro binding assays (ITC, calorimetry); phosphomutant KLC1 (T466E); quantitative transport imaging in neurons; aged brain biochemistry Molecular biology of the cell Medium 29093025
2018 Biochemical characterization of the JIP1/KLC1-TPR interaction identified seven KLC1 residues critical for JIP1 binding. The autoinhibitory LFP-acidic motif of KLC1 only marginally inhibits JIP1 binding. JIP1 competes with alcadein-α (a W-acidic motif cargo) for the same KLC1-TPR footprint. Isothermal titration calorimetry (ITC); truncation mapping; competitive binding assays; structural footprinting The Journal of biological chemistry Medium 30026235
2018 JIP1-mediated JNK activation negatively regulates synaptic plasticity and spatial memory: Jip1 knock-in mice with a point mutation that blocks JIP1-mediated JNK activation show increased NMDAR currents, lower threshold for hippocampal LTP induction, and improved hippocampus-dependent spatial memory and fear conditioning. Jip1 knock-in mice (point mutation blocking JNK activation); electrophysiology (NMDAR currents, LTP); behavioral tests (Morris water maze, fear conditioning); second independent Jip1 mutant mouse line The Journal of neuroscience High 29540552
2022 Cdk5 phosphorylates JIP1 at Thr205, enhancing axonal outgrowth. Phospho-JIP1(Thr205) amplifies phosphorylation of Itch (E3 ubiquitin ligase), increasing Notch1 ubiquitination and degradation, thereby reducing Notch1-IC levels that would otherwise inhibit axonal outgrowth. A phosphomimic JIP1(T205E) rescues axonal outgrowth defects in JIP1−/− and p35−/− neurons. Interactome screen; in vitro and in vivo phosphorylation assays; phosphomimic/phosphodeficient mutants; rescue experiments in knockout neurons; Notch1 ubiquitination assay BMC biology Medium 35581583
2025 NMR spectroscopy revealed that JNK1 engages the intrinsically disordered JIP1 tail at not only the canonical D-motif but also a non-canonical F-motif, establishing a bipartite binding mode. Crystal structure of JIP1–JNK1 complex at 2.35 Å confirmed this bipartite interaction. NMR spectroscopy of the JIP1 disordered tail; X-ray crystallography of JIP1–JNK1 complex at 2.35 Å Proceedings of the National Academy of Sciences of the United States of America High 39999166
2024 JIP1 and JIP2 heterodimerize via their SH3 domains with affinity comparable to homodimerization. Crystal structure of JIP1–JIP2 SH3 heterodimer revealed how structural features from each homodimer are used to stabilize the heterodimer. Targeted mutations disrupting dimerization impaired JNK pathway activation in cellulo. NMR spectroscopy; X-ray crystallography of JIP2 SH3 homodimer and JIP1–JIP2 SH3 heterodimer; mutagenesis and JNK activity assay in cells Structure (London, England : 1993) High 39013462
2013 In Drosophila muscles, Aplip1 (JIP1 ortholog) localizes to the myotendinous junction. Aplip1 mutations cause myonuclear mispositioning and muscle instability. Aplip1 genetically interacts with Raps/Pins and kinesin for nuclear positioning, and both Dynein and Kinesin localization are disrupted in Aplip1 mutants, indicating JIP1 regulates Dynein- and Kinesin-mediated nuclear pulling. Aplip1 mutant Drosophila; genetic interaction with Raps/Pins and Kinesin; immunofluorescence of motor localization; live imaging of nuclear dynamics Journal of cell science Medium 29487176
2017 DUSP1 (dual-specificity phosphatase 1) interaction with the JIP1 scaffold protein prevents DUSP1-mediated dephosphorylation of JNK, protecting AP-1 activation and cytokine production from DUSP1 inhibition during viral infection. Co-immunoprecipitation; JNK phosphorylation assays; AP-1 reporter assay; siRNA knockdown of DUSP1 and JIP1 Scientific reports Medium 29234123
2022 JNK3, JIP1, and β-arrestin2 co-localize and form complexes with PSD95 at postsynaptic densities in hippocampal neurons, as demonstrated by super-resolution microscopy and co-immunoprecipitation. Super-resolution microscopy (STED/STORM); co-immunoprecipitation from primary hippocampal neurons International journal of molecular sciences Medium 35456931
2013 JIP1 PTB domain (specifically residue F687) is required for JIP1–kinesin-1 binding and neurite tip localization. JIP3 is a major JIP1-binding protein identified by proteomics; JIP1–JIP3 association is F687-dependent and forms a stable ternary complex with kinesin-1. Other PTB-binding proteins can disrupt this ternary complex. Co-immunoprecipitation; site-directed mutagenesis (F687); proteomic analysis; subcellular localization imaging in Neuro2a cells BMC cell biology Medium 23496950
2017 Class I HDAC inhibitors induce JIP1 expression in cardiomyocytes, leading to elevated KIF5A expression and formation of JIP1:KIF5A:microtubule complexes that regulate intracellular cargo (autophagosome) transport, without significantly altering JNK signaling in this context. HDAC inhibitor treatment; JIP1 knockdown; KIF5A expression analysis; co-immunoprecipitation of JIP1:KIF5A:microtubule complex; autophagosome transport imaging Journal of molecular and cellular cardiology Medium 28886967
2013 JIP1 and POSH form a multiprotein scaffold network for TCR-mediated JNK1 activation in CD8+ T cells. Disruption of the POSH/JIP1 complex impairs JNK1 activation, reduces c-Jun, T-bet, and Eomesodermin induction, and results in impaired T cell proliferation, cytokine production, and anti-tumor responses. Co-immunoprecipitation; dominant-negative disruption of POSH/JIP1 complex; JNK1 kinase assay; transcription factor assays; tumor clearance assay European journal of immunology Medium 23963642

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125. The EMBO journal 228 15141161
2001 Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes & development 210 11562351
2013 JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors. The Journal of cell biology 209 23897889
2014 LC3 binding to the scaffolding protein JIP1 regulates processive dynein-driven transport of autophagosomes. Developmental cell 164 24914561
2000 The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Nature genetics 157 10700186
2001 Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). The Journal of biological chemistry 148 11724784
2009 Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. The Journal of biological chemistry 135 19491104
1998 IB1, a JIP-1-related nuclear protein present in insulin-secreting cells. The Journal of biological chemistry 129 9442013
2005 APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila. Current biology : CB 114 16332540
2000 IB1 reduces cytokine-induced apoptosis of insulin-secreting cells. The Journal of biological chemistry 114 10748095
2000 Inhibition of JNK by overexpression of the JNL binding domain of JIP-1 prevents apoptosis in sympathetic neurons. The Journal of biological chemistry 103 11121395
2004 An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes & development 99 15314024
2008 The JIP1 scaffold protein regulates axonal development in cortical neurons. Current biology : CB 83 18261906
2013 Expanding the indications for radical trachelectomy: a report on 29 patients with stage IB1 tumors measuring 2 to 4 centimeters. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 73 23714706
2003 Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation. The Journal of biological chemistry 72 12756254
2005 Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop. The Journal of cell biology 62 15998799
2008 Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. PloS one 58 18286207
2014 JIP1 mediates anterograde transport of Rab10 cargos during neuronal polarization. The Journal of neuroscience : the official journal of the Society for Neuroscience 57 24478353
2005 The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1. Developmental biology 52 15572149
2003 The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic beta cells. Journal of cell science 52 12640031
2000 Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain. The European journal of neuroscience 52 10712642
2018 Codelivery of doxorubicin and JIP1 siRNA with novel EphA2-targeted PEGylated cationic nanoliposomes to overcome osteosarcoma multidrug resistance. International journal of nanomedicine 49 30013340
2017 Anti-inflammatory Effect of Glucagon Like Peptide-1 Receptor Agonist, Exendin-4, through Modulation of IB1/JIP1 Expression and JNK Signaling in Stroke. Experimental neurobiology 49 28912645
2014 Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport. Molecular biology of the cell 46 25165140
1999 Molecular cloning of multiple splicing variants of JIP-1 preferentially expressed in brain. Journal of neurochemistry 45 10098834
2003 Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK-interacting protein (JIP)-1. The Journal of biological chemistry 42 12917434
2011 Parametrial involvement in FIGO stage IB1 cervical carcinoma diagnostic impact of tumor diameter in preoperative magnetic resonance imaging. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 41 21721193
2001 The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1). Molecular and cellular biology 41 11585908
2006 A unique set of SH3-SH3 interactions controls IB1 homodimerization. The EMBO journal 40 16456539
2001 Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. Journal of biochemistry 40 11726277
1986 Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6. Biochemistry 39 3521730
2012 Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin. Oncotarget 33 23045411
2005 Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. The Journal of biological chemistry 33 15911620
2003 Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease. Molecular psychiatry 33 12740599
2019 Fertility-sparing surgery of cervical cancer >2 cm (International Federation of Gynecology and Obstetrics 2009 stage IB1-IIA) after neoadjuvant chemotherapy. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 32 31744889
2014 MAPK8IP1/JIP1 regulates the trafficking of autophagosomes in neurons. Autophagy 32 25483967
2013 The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex. The Journal of biological chemistry 31 23770673
2007 Src family kinases directly regulate JIP1 module dynamics and activation. Molecular and cellular biology 30 17242197
2003 Repression of phospho-JNK and infarct volume in ischemic brain of JIP1-deficient mice. Journal of neuroscience research 30 14515362
1999 Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene. Genomics 30 9933567
2020 Laparoscopic versus abdominal radical hysterectomy for stage IB1 cervical cancer patients with tumor size ≤ 2 cm: a case-matched control study. International journal of clinical oncology 29 32062731
2018 Surgical and Oncologic Outcomes of Radical Abdominal Trachelectomy Versus Hysterectomy for Stage IA2-IB1 Cervical Cancer. Journal of minimally invasive gynecology 29 29908338
2017 JIP1 and JIP3 cooperate to mediate TrkB anterograde axonal transport by activating kinesin-1. Cellular and molecular life sciences : CMLS 28 28638935
2011 Understanding the specificity of a docking interaction between JNK1 and the scaffolding protein JIP1. The journal of physical chemistry. B 28 21261310
2018 JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. The Journal of neuroscience : the official journal of the Society for Neuroscience 27 29540552
2005 IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation. Cellular signalling 26 15894166
2002 The scaffold protein IB1/JIP-1 controls the activation of JNK in rat stressed urothelium. Journal of cell science 26 11839789
2006 Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling. Journal of virology 25 16840345
2004 JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA). British journal of cancer 25 15138488
2016 Acute and Chronic Hyperglycemia Elicit JIP1/JNK-Mediated Endothelial Vasodilator Dysfunction of Retinal Arterioles. Investigative ophthalmology & visual science 23 27556216
2016 Direct targeting of MAPK8IP1 by miR-10a-5p is a major mechanism for gastric cancer metastasis. Oncology letters 23 28454224
2005 JIP1 regulates neuronal apoptosis in response to stress. Brain research. Molecular brain research 23 15836924
2017 DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection. Scientific reports 22 29234123
2010 Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance. Molecular and cellular biology 22 20679483
2012 Surgical-pathologic risk factors of pelvic lymph node metastasis in stage Ib1-IIb cervical cancer. Acta obstetricia et gynecologica Scandinavica 20 22486458
2008 The docking properties of SHIP2 influence both JIP1 tyrosine phosphorylation and JNK activity. Cellular signalling 20 18486448
2003 Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling. Diabetes 19 14514632
2018 The potential role of HO-1 in regulating the MLK3-MKK7-JNK3 module scaffolded by JIP1 during cerebral ischemia/reperfusion in rats. Behavioural brain research 18 30412737
2012 Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death. The Journal of biological chemistry 18 23172226
2003 Increased vulnerability to kainic acid-induced epileptic seizures in mice underexpressing the scaffold protein Islet-Brain 1/JIP-1. The European journal of neuroscience 18 12823467
2015 The potential for less radical surgery in women with stage IA2-IB1 cervical cancer. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 17 26070225
2013 Regulation of axon growth by the JIP1-AKT axis. Journal of cell science 17 24198394
2010 Regulation of stress-associated scaffold proteins JIP1 and JIP3 on the c-Jun NH2-terminal kinase in ischemia-reperfusion. Canadian journal of physiology and pharmacology 17 21076496
2021 Oncologic and obstetric outcomes after simple conization for fertility-sparing surgery in FIGO 2018 stage IB1 cervical cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 16 33649013
2011 Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis. Experimental cell research 16 21237154
2025 Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT axis. Journal of nanobiotechnology 15 39849453
2017 Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1. Molecular biology of the cell 15 29093025
2015 Fertility-sparing management of a stage IB1 small cell neuroendocrine cervical carcinoma with radical abdominal trachelectomy and adjuvant chemotherapy. Gynecologic oncology reports 15 26425709
2010 JIP1 binding to RBP-Jk mediates cross-talk between the Notch1 and JIP1-JNK signaling pathway. Cell death and differentiation 15 20508646
1998 Ovarian metastasis of stage IB1 squamous cell cancer of the cervix after radical parametrectomy and oophoropexy. Gynecologic oncology 15 9514804
2013 The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells. European journal of immunology 14 23963642
2013 Current surgical principle for uterine cervical cancer of stages Ia2, Ib1, and IIa1 in Japan: a survey of the Japanese Gynecologic Oncology Group. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 14 24172100
2007 Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia. Biochemistry 14 17348686
2017 Case report: term birth after fertility-sparing treatments for stage IB1 small cell neuroendocrine carcinoma of the cervix. BMC women's health 13 28754175
2016 Can pelvic lymphadenectomy be omitted in patients with stage IA2, IB1, and IIA1 squamous cell cervical cancer? SpringerPlus 13 27536545
2015 Pretreatment risk factors for parametrial involvement in FIGO stage IB1 cervical cancer. Journal of gynecologic oncology 13 26197769
2014 Radical Abdominal Trachelectomy for IB1 Cervical Cancer at 17 Weeks of Gestation: A Case Report and Literature Review. Case reports in obstetrics and gynecology 13 25548694
2017 Class I HDACs control a JIP1-dependent pathway for kinesin-microtubule binding in cardiomyocytes. Journal of molecular and cellular cardiology 12 28886967
2017 Comparison of survival outcomes between radical hysterectomy and definitive radiochemotherapy in stage IB1 and IIA1 cervical cancer. Cancer management and research 12 29270030
2014 Reassembly of JIP1 scaffold complex in JNK MAP kinase pathway using heterologous protein interactions. PloS one 11 24816971
2022 Risk Factor Assessment of Lymph Node Metastasis in Patients With FIGO Stage IB1 Cervical Cancer. Frontiers in oncology 10 35433446
2007 Splice variant-specific stabilization of JNKs by IB1/JIP1. Cellular signalling 10 17669625
2024 Lacticaseibacillus casei IB1 Alleviates DSS-Induced Inflammatory Bowel Disease by Regulating the Microbiota and Restoring the Intestinal Epithelial Barrier. Microorganisms 9 39065147
2018 Simple trachelectomy with pelvic lymphadenectomy as a viable treatment option in pregnant patients with stage IB1 (≥2 cm) cervical cancer: Bridging the gap to fetal viability. Gynecologic oncology 9 29804639
2012 Clinical significance of peritumoral lymphatic vessel density and lymphatic vessel invasion detected by D2-40 immunostaining in FIGO Ib1-IIa squamous cell cervical cancer. Cell and tissue research 9 22492093
2022 Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition. BMC biology 8 35581583
2018 Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1). The Journal of biological chemistry 8 30026235
2013 The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain. BMC cell biology 8 23496950
2009 Postpartum radical trachelectomy for IB1 squamous cell carcinoma of the cervix diagnosed in pregnancy. American journal of obstetrics and gynecology 8 19695559
2022 Chemotherapy versus chemoradiotherapy for FIGO stages IB1 and IIA1 cervical squamous cancer patients with lymphovascular space invasion: a retrospective study. BMC cancer 7 35193525
2019 JIP1 Deficiency Protects Retinal Ganglion Cells From Apoptosis in a Rotenone-Induced Injury Model. Frontiers in cell and developmental biology 7 31681759
2015 [Surgery alone or in association with preoperative uterovaginal brachytherapy for stage IB1 cervical cancer: Toxicities profiles]. Gynecologie, obstetrique & fertilite 7 25986397
2015 Pretreatment Factors Associated with Recurrence for Patients with Cervical Cancer International Federation of Gynecology and Obstetrics Stage IB1 Disease. Gynecologic and obstetric investigation 7 26580917
2018 Aplip1, the Drosophila homolog of JIP1, regulates myonuclear positioning and muscle stability. Journal of cell science 6 29487176
2008 Matched-case comparison for the role of surgery in FIGO stage Ib1-IIa squamous cell carcinoma of cervix and suspicious para-aortic lymph node metastasis. Annals of surgical oncology 6 18979134
2022 Colocalization and Interaction Study of Neuronal JNK3, JIP1, and β-Arrestin2 Together with PSD95. International journal of molecular sciences 5 35456931
2009 Expression of JNK-interacting protein JIP-1 and insulin-like growth factor II in Wilms tumour cell lines and primary Wilms tumours. Anticancer research 5 19596915
2025 Bipartite binding of the intrinsically disordered scaffold protein JIP1 to the kinase JNK1. Proceedings of the National Academy of Sciences of the United States of America 4 39999166
2024 Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1. Structure (London, England : 1993) 4 39013462
2001 Connexin26 is regulated in rat urothelium by the scaffold protein IB1/JIP-1. Cell communication & adhesion 4 12064607

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