Affinage

IL18R1

Interleukin-18 receptor 1 · UniProt Q13478

Length
541 aa
Mass
62.3 kDa
Annotated
2026-04-28
53 papers in source corpus 21 papers cited in narrative 22 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IL18R1 (IL-18Rα) is the ligand-binding subunit of the heterodimeric IL-18 receptor complex, which transduces signals from IL-18 to drive innate and adaptive immune responses, inflammatory cell migration, and hematopoietic stem cell quiescence. IL-18Rα alone binds IL-18 but requires co-expression of IL-18Rβ to activate downstream NF-κB, AP-1, JNK, and PI3K/Akt signaling, with the receptor complex physically associating with Nox1 to generate ROS that amplify these cascades (PMID:11123287, PMID:23541442). T cell-intrinsic IL-18R/MyD88 signaling is essential for Th1 proliferation, CD4 cytotoxic T cell differentiation, and γδ T cell effector function during intracellular pathogen infection, and also constrains ILC expansion by inhibiting proliferation and inducing apoptosis (PMID:28895840, PMID:35670567, PMID:32450614, PMID:35874724). IL18R1 transcription is repressed by GATA-3 and Stat6 during Th2 differentiation, and its downregulation via TGF-β/IFN-αβ-dependent suppression of Tcf-1 marks kidney tissue-resident CD8+ T cells (PMID:18714006, PMID:33474536).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1996 High

    Before its ligand was known, the identification of IL18R1 as a novel IL-1R family member whose cytoplasmic domain could activate NF-κB established that this orphan receptor possessed intrinsic signaling competence through the TIR domain.

    Evidence Chimeric receptor (IL-1R ectodomain/IL18R1 cytoplasmic domain) transfected into COS cells with NF-κB and IL-8 promoter reporter assays

    PMID:8626725

    Open questions at the time
    • Cognate ligand not yet identified
    • Accessory chain requirement unknown
    • Downstream adaptor molecules not defined
  2. 2001 High

    The requirement for a heterodimeric receptor was resolved when reconstitution showed that IL-18Rα alone binds IL-18 but cannot signal, and co-expression of IL-18Rβ restores IL-18-dependent NF-κB activation and cytokine induction.

    Evidence COS-1 transfection of IL-18Rβ cDNA, luciferase reporter, IL-8 ELISA, anti-IL-18Rα blocking antibody

    PMID:11123287

    Open questions at the time
    • Structural basis of α/β heterodimerization not determined
    • Stoichiometry of receptor complex not addressed
    • Identity of a second IL-18R ligand (IL-1H) only preliminarily characterized
  3. 2002 High

    IL-18Rα expression was shown to be dynamically regulated during Th1/Th2 differentiation: IL-12 upregulates both receptor chains, while IL-4 suppresses IL-18Rα unless IFN-γ counteracts, establishing IL-18Rα surface levels as a checkpoint in T helper lineage commitment.

    Evidence T cell differentiation using IFN-γ−/− mice, IL-4 neutralization, flow cytometry for surface IL-18Rα

    PMID:11123287 PMID:12055229

    Open questions at the time
    • Cis-regulatory elements governing IL-18Rα transcription not mapped
    • Direct versus indirect effects of IFN-γ on IL-18Rα promoter not resolved
  4. 2003 Medium

    Beyond immune signaling, IL-18R was found to mediate direct cell motility: IL-18 induces actin polymerization and chemotaxis in dendritic cells, and NF-κB-dependent IL-18Rβ upregulation in cardiomyocytes established the receptor's role outside classical lymphoid compartments.

    Evidence Boyden chamber migration assay and F-actin staining on monocyte-derived DCs; NF-κB inhibitor (PDTC) treatment in primary cardiomyocytes

    PMID:12684057 PMID:14662834

    Open questions at the time
    • Signaling intermediates linking IL-18R to actin remodeling not identified
    • In vivo relevance of DC migration via IL-18R not tested
  5. 2008 High

    The transcriptional basis of IL-18Rα silencing in Th2 cells was defined: GATA-3 directly binds the Il18r1 locus at conserved non-coding regions and represses transcription, and this repression requires Stat6, linking IL-4/Stat6/GATA-3 to chromatin-level control of IL-18 responsiveness.

    Evidence ChIP for GATA-3, DNase hypersensitivity assay, ectopic GATA-3 in Th1 cells, Stat6−/− mice

    PMID:18714006

    Open questions at the time
    • Precise enhancer-promoter architecture of the Il18r1 locus not resolved
    • Whether GATA-3-mediated repression is reversible in committed Th2 cells not tested
  6. 2013 High

    The discovery that IL-18Rα/β physically associates with Nox1 and that IL-18 enhances this interaction revealed a proximal ROS-generating mechanism upstream of NF-κB/JNK and TRAF3IP2, explaining how IL-18R drives smooth muscle cell migration.

    Evidence Co-immunoprecipitation and GST pull-down for IL-18R/Nox1 association; Nox1 ROS assay, NF-κB/AP-1 reporters, and migration assay in human coronary artery SMCs

    PMID:23541442

    Open questions at the time
    • Binding interface between IL-18R and Nox1 not mapped
    • Whether IL-18R/Nox1 complex forms in other cell types not tested
  7. 2017 High

    Using mixed bone marrow chimeras and adoptive transfer rescue, IL-18R/MyD88 was established as a T cell-intrinsic signaling axis essential for Th1 proliferation, survival, and host protection against intracellular pathogens (T. cruzi, Salmonella, Chlamydia, Brucella).

    Evidence Il18r1−/− and Myd88−/− mixed chimeras, transcriptomics, adoptive transfer of WT CD4+ T cells, multiple intracellular pathogen infection models

    PMID:28817719 PMID:28895840

    Open questions at the time
    • Specific MyD88-dependent transcriptional targets downstream of IL-18R in T cells not fully cataloged
    • Whether IL-18R signals through IRAK kinases in T cells not directly shown
  8. 2020 High

    IL-18R/MyD88 signaling was shown to be intrinsically required not only in CD4+ T cells but also in γδ T cells for their proliferation and cytotoxic effector function during T. cruzi infection, broadening the receptor's role to unconventional T cell subsets.

    Evidence Il18r1−/− mice, adoptive transfer of WT γδ T cells rescuing susceptibility, intracellular cytokine staining

    PMID:32450614

    Open questions at the time
    • Molecular basis of IL-18R regulation of granzyme B expression in γδ T cells not defined
    • Whether IL-18R signaling differs mechanistically in γδ versus αβ T cells not addressed
  9. 2021 High

    Two new biological contexts for IL-18R were established: cell-intrinsic IL-18R signaling drives hematopoietic stem cell quiescence during severe infection, and downregulation of IL-18R via TGF-β/IFN-αβ/Tcf-1 suppression marks kidney tissue-resident CD8+ T cells.

    Evidence Il18r1−/− mice in Ehrlichia infection for HSC quiescence; parabiosis, scRNA-seq, and cytokine pathway dissection for kidney Trm

    PMID:33474536 PMID:34798063

    Open questions at the time
    • Mechanism by which IL-18R enforces HSC quiescence (cell cycle arrest pathway) not identified
    • Whether IL-18R downregulation is a universal Trm marker across tissues not determined
  10. 2022 High

    IL-18R/MyD88 was identified as the critical T cell-intrinsic pathway for CD4 cytotoxic T lymphocyte (CD4CTL) differentiation, with Il18r1−/− and Myd88−/− CD4+ T cells phenocopying each other in mixed chimeras, and IL-18R signaling was separately shown to constrain ILC expansion by inhibiting proliferation and inducing apoptosis.

    Evidence Mixed bone marrow chimeras, adoptive transfer of GzB+ CD4+ T cells, single-cell transcriptomics for CD4CTL; Il18r1−/− and Il18−/− mice with in vitro ILC differentiation and adoptive transfer for ILC function

    PMID:35670567 PMID:35874724

    Open questions at the time
    • Epigenetic programs downstream of IL-18R that commit CD4 cells to cytotoxic fate not mapped
    • Whether IL-18R-mediated ILC apoptosis is caspase-dependent not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of IL-18Rα/IL-18Rβ heterodimerization, the full spectrum of adaptor complexes recruited to the IL-18R TIR domain in different cell types, and whether IL-18R signals through distinct downstream pathways in hematopoietic stem cells versus lymphocytes.
  • No crystal or cryo-EM structure of the IL-18/IL-18Rα/IL-18Rβ signaling complex
  • IRAK recruitment to IL-18R TIR domain not directly demonstrated
  • Cell-type-specific signaling outputs downstream of IL-18R not systematically compared

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 2 GO:0060090 molecular adaptor activity 2
Localization
GO:0005886 plasma membrane 3
Pathway
R-HSA-168256 Immune System 6 R-HSA-162582 Signal Transduction 5
Partners
GATA3IL18IL18RAPMYD88NOX1TRAF3IP2
Complex memberships
IL-18R/Nox1 complexIL-18Rα/IL-18Rβ heterodimer

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 IL18R1 (IL-1Rrp) was identified as a novel IL-1 receptor family member whose cytoplasmic domain, when fused to the IL-1R extracellular/transmembrane regions, signals through NF-κB activation and IL-8 promoter induction in response to IL-1, demonstrating that the IL18R1 cytoplasmic domain is functionally competent for downstream signaling. Chimeric receptor transfection into COS cells, NF-κB reporter assay, IL-8 promoter assay The Journal of biological chemistry High 8626725
2001 Functional IL-18 signaling requires both IL-18Rα and IL-18Rβ chains: COS-1 cells expressing IL-18Rα alone do not respond to IL-18, but transfection of IL-18Rβ cDNA reconstitutes IL-18-induced IL-8 and luciferase reporter activity; antibody blocking of IL-18Rα abolishes this response, establishing that both chains are necessary for a functional receptor complex. Transient transfection of IL-18Rβ cDNA into COS-1 cells, luciferase reporter assay, IL-8 measurement, anti-IL-18Rα blocking antibody Journal of immunology High 11123287
2001 IL-1H (a novel IL-1-related molecule) binds the IL-18 receptor but not the IL-1 receptor, identifying it as a second ligand for the IL-18R axis. Receptor binding assay using recombinant protein expressed in mammalian cells Cytokine Medium 11145836
2001 IL-12 upregulates steady-state mRNA levels of both IL-18Rα and IL-18Rβ chains in NKO cells and PBMC, and IFN-γ production correlates with this IL-12-induced upregulation, indicating that IL-12 amplifies IL-18 signaling capacity by increasing receptor expression. RT-PCR/Northern blot for receptor mRNA, IFN-γ ELISA, NK cell line and PBMC stimulation assays Journal of immunology Medium 11123287
2002 IFN-γ regulates IL-18Rα expression during Th1 differentiation by counteracting the negative effects of IL-4 on IL-18Rα upregulation; in the absence of IL-4, IL-12-driven IL-18Rα upregulation is IFN-γ-independent, but in the presence of IL-4, IFN-γ is required to preserve IL-18Rα expression. T cell differentiation assays using IFN-γ-/- mice, IL-4 neutralization, flow cytometry for IL-18Rα surface expression Journal of immunology High 12055229
2002 A 3-base deletion splice variant (950delCAG) of the IL-18Rα chain cDNA is associated with reduced IFN-γ production in response to IL-18 stimulation, indicating that this alternative splicing event impairs receptor function. cDNA sequencing of IL-18Rα from atopic patients, PBMC IL-18 stimulation assays, IFN-γ measurement The Journal of allergy and clinical immunology Medium 11941317
2003 A splice variant of IL-18Rβ encoding only the first immunoglobulin-like domain (predicted soluble truncated form) is expressed in rat brain regions and glial cells, and is rapidly upregulated in microglia by LPS, suggesting it acts as an endogenous regulator of IL-18 activity analogous to the soluble IL-1R accessory protein. RT-PCR identification of splice variant, cell-type-specific expression in purified microglia/astrocytes/neurons, LPS stimulation Journal of neuroimmunology Medium 14644029
2003 TNF-α and H2O2 induce IL-18Rβ (but not IL-18Rα) expression in cardiomyocytes via NF-κB activation, as demonstrated by PDTC (NF-κB inhibitor) blocking of agonist-induced IL-18Rβ expression while not affecting basal IL-18Rα expression. NF-κB activation assays, mRNA/protein expression analysis, PDTC inhibitor treatment in primary cardiomyocytes Biochemical and biophysical research communications Medium 12684057
2003 IL-18R is expressed on human dendritic cells and IFN-γ upregulates its surface expression on monocyte-derived DCs; IL-18 directly induces filamentous actin polymerization and DC migration in Boyden chamber assays, demonstrating a chemoattractant function of IL-18/IL-18R signaling on DCs. Flow cytometry for IL-18R expression, IFN-γ stimulation, filamentous actin staining, Boyden chamber migration assay Journal of immunology Medium 14662834
2008 Transcription factor GATA-3 binds to the Il18r1 locus at conserved non-coding sequences overlapping with DNase hypersensitivity sites, and ectopic GATA-3 expression in differentiated Th1 cells represses Il18r1 mRNA and surface expression of IL-18Rα; Stat6 is required for Il18r1 repression during Th2 differentiation. Chromatin remodeling (DNase hypersensitivity assay), ChIP for GATA-3 and Stat6, histone modification analysis, ectopic GATA-3 expression, Stat6-/- mice Journal of immunology High 18714006
2013 IL-18R subunits (IL-18Rα and IL-18Rβ) physically associate with Nox1 under basal conditions, and IL-18 stimulation enhances this IL-18R/Nox1 binding; this complex drives Nox1-dependent ROS generation leading to TRAF3IP2 induction and IKK/NF-κB and JNK/AP-1 activation in human coronary artery smooth muscle cells, mediating IL-18-induced SMC migration. Co-immunoprecipitation, GST pull-down, Nox1 ROS assay, NF-κB/AP-1 reporter assays, migration assay Cellular signalling High 23541442
2014 IL-18 induces its own expression and that of IL-18Rα via AP-1 activation, and promotes cardiomyocyte hypertrophy in part via PI3K/Akt/GATA4 signaling; cyclical mechanical stretch enhances ANP, IL-18, and IL-18Rα expression in primary rabbit cardiomyocytes. Primary rabbit cardiomyocyte culture, cyclic stretch model, rabbit IL-18Rα cDNA cloning, AP-1 reporter, PI3K/Akt/GATA4 pathway inhibitors Journal of molecular and cellular cardiology Medium 25108227
2017 T cell-intrinsic IL-18R and MyD88 signaling are required for Th1 cell proliferation, protection from apoptosis, and expression of activation/memory genes during Trypanosoma cruzi infection; Il18r1-deficient mice exhibit lower Th1 cell levels and higher susceptibility to infection, rescued by adoptive transfer of WT CD4+ T cells, establishing IL-18R/MyD88 as a critical T cell-intrinsic pathway for cognate Th1 responses. Mixed bone marrow chimeras, transcriptome analysis, cytometry, Il18r1-/- mice, adoptive transfer rescue experiment eLife High 28895840
2017 CD4 Th1 cell expression of both IL-18R and DR3 (but not IL-15R) is required for optimal TCR-independent (non-cognate) IFN-γ induction in Salmonella-infected mice; T cell-intrinsic MyD88 deficiency increases bacterial burden in Salmonella, Chlamydia, and Brucella infections. Knockout mouse models for IL-18R, DR3, IL-15R, and MyD88; intracellular IFN-γ staining; bacterial burden measurements PLoS pathogens High 28817719
2020 IL-18R signaling is intrinsically required in γδ T cells for their proliferation, generation of cytotoxic GzB+ and IFN-γ-producing γδ T cells, and protection against T. cruzi infection; adoptive transfer of WT γδ T cells rescues Il18r1-/- mice from susceptibility. Il18r1-/- and Myd88-/- mice, in vivo/in vitro proliferation assays, intracellular cytokine staining, adoptive transfer Journal of leukocyte biology High 32450614
2021 IL-18R signaling is cell-intrinsically required for short-term HSC quiescence (but not for HSPC cell death) during severe infection; IFN-αβ promote IL-18 expression, which through IL-18R drives ST-HSC quiescence, contributing to bone marrow aplasia. Il18r1-/- mice, Il18-/- mice, Ixodes ovatus Ehrlichia infection model, flow cytometry, bone marrow transplantation assays Stem cell reports High 34798063
2021 Downregulation of IL-18R expression marks bona fide tissue-resident (Trm) CD8+ T cells in the kidney; TGF-β and IFN-α/β, and TGF-β-dependent suppression of Tcf-1, are required for IL-18R downregulation during kidney Trm differentiation, as demonstrated by parabiosis and transcriptional analysis. Parabiosis experiments, global transcriptional analysis (scRNA-seq), flow cytometry, cytokine blocking/knockout, Tcf-1 reporter iScience High 33474536
2022 CD4+ cytotoxic T cell (CD4CTL) differentiation and function during T. cruzi infection require T cell-intrinsic IL-18R/MyD88 signaling; Il18ra-/- and Myd88-/- CD4+ T cells phenocopy each other in mixed bone marrow chimeras, and adoptive transfer of WT CD4+GzB+ T cells to infected Il18ra-/- mice extends survival. Mixed bone marrow chimeras, Il18ra-/- and Myd88-/- mice, adoptive transfer, cytotoxicity assays, single-cell transcriptomics eLife High 35670567
2022 IL18/IL18R1 signaling promotes NF-κB nuclear entry and activates the HIF-1 signaling pathway in macrophages, as shown by proteomic analysis; macrophage-derived IL-18 acting through IL18R1 promotes M1 macrophage polarization and synthetic phenotype transformation of vascular smooth muscle cells. Intercellular communication analysis (scRNA-seq), proteomic analysis, pseudo-time analysis, VIPER analysis Frontiers in immunology Medium 35069552
2022 IL-18/IL-18R signaling in IL-18R+ NK cells and T cells drives IFN-γ production, which in turn stimulates ROS-mediated bactericidal activity in neutrophils, restricting Legionella longbeachae infection; this IL-18R/IFN-γ/ROS axis was defined using cell ablation experiments and IL-18 deficiency. Cell type ablation, IL-18R expression profiling, IL-18-deficient mice, ROS measurement, IFN-γ assays, infection model Mucosal immunology Medium 38750967
2022 IL-18R signaling prevents IL-17A production from ILC2s in the lung during fungal allergen exposure; in IL-18R-/- mice, both ST2+ and ST2-negative ILCs show increased IL-17A production and enhanced lung eosinophilia, with IL-18 expressed by alveolar macrophages acting on IL-13+ILC2s expressing IL-18R. IL-18R-/- mice, Alternaria alternata challenge model, scRNA-seq, flow cytometry, cytokine production assays bioRxivpreprint Medium 40777291
2022 IL-18/IL-18R signaling suppresses the growth of ILC precursors (ILCPs) and ILCs by inhibiting proliferation and inducing apoptosis under elevated IL-18 conditions; Il18r1-deficient lymphoid progenitors can still generate all ILC subsets, indicating IL-18R is not required for ILC lineage commitment but constrains ILC expansion. Il18r1-/- and Il18-/- mice, in vitro differentiation assay, adoptive transfer, single-cell gene expression analysis Frontiers in immunology High 35874724

Source papers

Stage 0 corpus · 53 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. The Journal of biological chemistry 197 8626725
2001 IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp. Cytokine 169 11145836
2002 Role of IFN-gamma in Th1 differentiation: IFN-gamma regulates IL-18R alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression. Journal of immunology (Baltimore, Md. : 1950) 103 12055229
1999 Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. Genomics 88 10191101
2003 TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation. Biochemical and biophysical research communications 79 12684057
2012 Role of P2X7 receptor-mediated IL-18/IL-18R signaling in morphine tolerance: multiple glial-neuronal dialogues in the rat spinal cord. The journal of pain 77 22968128
2003 Human dendritic cells express the IL-18R and are chemoattracted to IL-18. Journal of immunology (Baltimore, Md. : 1950) 77 14662834
2001 Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain. Journal of immunology (Baltimore, Md. : 1950) 72 11123287
2017 Increased adipose tissue expression of IL-18R and its ligand IL-18 associates with inflammation and insulin resistance in obesity. Immunity, inflammation and disease 49 28508444
2000 Expression and responsiveness of human interleukin-18 receptor (IL-18R) on hematopoietic cell lines. Leukemia 48 10865972
2009 Expression of interleukin-18, IL-18BP, and IL-18R in serum, synovial fluid, and synovial tissue in patients with rheumatoid arthritis. Clinical and experimental medicine 43 19225717
2014 Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-α-induced cardiomyocyte death. Journal of molecular and cellular cardiology 42 25108227
2011 Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans. PloS one 37 22039448
2003 Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain. Journal of neuroimmunology 36 14644029
2020 Microglia-Astrocyte Cross Talk through IL-18/IL-18R Signaling Modulates Migraine-like Behavior in Experimental Models of Migraine. Neuroscience 35 33137409
2011 Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in humoral immunity to smallpox vaccination in Caucasians and African Americans. The Journal of infectious diseases 30 21742843
2017 T cell expression of IL-18R and DR3 is essential for non-cognate stimulation of Th1 cells and optimal clearance of intracellular bacteria. PLoS pathogens 27 28817719
2022 Cardiovascular Risk After SARS-CoV-2 Infection Is Mediated by IL18/IL18R1/HIF-1 Signaling Pathway Axis. Frontiers in immunology 24 35069552
2008 Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: effect of TNF-alpha and IFN-gamma treatment. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 23 18547159
2008 Transcription factor-dependent chromatin remodeling of Il18r1 during Th1 and Th2 differentiation. Journal of immunology (Baltimore, Md. : 1950) 23 18714006
2015 T cell responses are elicited against Respiratory Syncytial Virus in the absence of signalling through TLRs, RLRs and IL-1R/IL-18R. Scientific reports 22 26688048
2012 An Association Study of Interleukin 18 Receptor Genes (IL18R1 and IL18RAP) in Lumbar Disc Degeneration. The open orthopaedics journal 22 22550553
2022 Cytotoxic CD4+ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts. eLife 21 35670567
2019 IL-18R-dependent and independent pathways account for IL-18-enhanced antitumor ability of CAR-T cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21 31914650
2017 Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection. eLife 21 28895840
2010 Behavioral and genetic investigations of low exploratory behavior in Il18r1(-/-) mice: we can't always blame it on the targeted gene. Brain, behavior, and immunity 19 20580925
2024 IL-18R supported CAR T cells targeting oncofetal tenascin C for the immunotherapy of pediatric sarcoma and brain tumors. Journal for immunotherapy of cancer 18 39572158
2021 New immunological potential markers for triple negative breast cancer: IL18R1, CD53, TRIM, Jaw1, LTB, PTPRCAP. Discover oncology 18 35201443
2017 Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R. Journal of cellular and molecular medicine 18 28922563
2013 Interleukin-18 enhances IL-18R/Nox1 binding, and mediates TRAF3IP2-dependent smooth muscle cell migration. Inhibition by simvastatin. Cellular signalling 17 23541442
2006 IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. The European respiratory journal 16 16971411
2002 Predominant expression of 950delCAG of IL-18R alpha chain cDNA is associated with reduced IFN-gamma production and high serum IgE levels in atopic Japanese children. The Journal of allergy and clinical immunology 16 11941317
2013 Genetic variation in IL18R1 and IL18 genes and Inteferon γ ELISPOT response to smallpox vaccination: an unexpected relationship. The Journal of infectious diseases 15 23901078
2015 Polymorphisms of ST2-IL18R1-IL18RAP gene cluster: a new risk for autoimmune thyroid diseases. International journal of immunogenetics 14 26566691
2009 Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. BMC medical genetics 13 19473509
2021 The downregulation of IL-18R defines bona fide kidney-resident CD8+ T cells. iScience 12 33474536
2021 IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock. Stem cell reports 12 34798063
2014 Association between gene polymorphisms in TIM1, TSLP, IL18R1 and childhood asthma in Turkish population. International journal of clinical and experimental medicine 12 24955184
2004 Expression of interleukin 12 receptor (IL-12R) and IL-18R on CD4+ T cells from patients with rheumatoid arthritis. The Journal of rheumatology 12 14994387
2022 IL-18BP Alleviates Anxiety-Like Behavior Induced by Traumatic Stress via Inhibition of the IL-18R-NLRP3 Signaling Pathway in a Mouse Model of Hemorrhagic Shock and Resuscitation. Molecular neurobiology 10 36269543
2022 IL-18/IL-18R Signaling Is Dispensable for ILC Development But Constrains the Growth of ILCP/ILCs. Frontiers in immunology 8 35874724
2020 Increased expression of serum IL-18 and IL-18R in newly diagnosed type 2 diabetes mellitus. Minerva endocrinology 7 33103874
2020 IL-18R signaling is required for γδ T cell response and confers resistance to Trypanosoma cruzi infection. Journal of leukocyte biology 6 32450614
2024 Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-γ/ROS axis in mice. Mucosal immunology 3 38750967
2025 Identification of genetic variants of the IL18R1 gene in association with COPD susceptibility. Annals of medicine 2 39847405
2025 The Potential Contribution of the IL-37/IL-18/IL-18BP/IL-18R Axis in the Pathogenesis of Sjögren's Syndrome. International journal of molecular sciences 2 40430016
2017 IL18 rs360719 A>G, IL18R1 rs13015714 G>T, IL18RAP rs917997 C>T and IL28B rs8099917 T>G polymorphisms and risk of gastric cardiac adenocarcinoma. Molecular and clinical oncology 1 29285382
2026 Serologic IL-18 increase with B-cell IL-18R loss characterizes selective IgA deficiency. Frontiers in immunology 0 41562052
2025 Serum IL-18R1 and its effect on immune cell infiltration in asthma. American journal of translational research 0 40226003
2025 Activation of IL-17+ ILC subsets in IL-18R-deficient mice during fungal allergen exposure. bioRxiv : the preprint server for biology 0 40777291
2025 Characteristics of Asthmatic Patients with IL18R1 Differential Expression in Induced Sputum. International archives of allergy and immunology 0 40784338
2025 Identification of IL18/IL18R1 signaling as a predictive biomarker of SGLT2 inhibitor efficacy in type 2 diabetes. iScience 0 41111914
2025 Predicted IL-18/IL-18R Binding Improvement Through Protein Interface Modification with Computer-Aided Design. Biomolecules 0 41154589