Affinage

Showing HAX1 — HAX-1 is a alias.

HAX1

HCLS1-associated protein X-1 · UniProt O00165

Length
279 aa
Mass
31.6 kDa
Annotated
2026-06-10
100 papers in source corpus 40 papers cited in narrative 40 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

HAX1 is a multifunctional, predominantly mitochondrial adaptor protein that suppresses apoptosis and coordinates cytoskeletal dynamics, calcium handling, and protein homeostasis through a large set of compartment-specific protein and RNA interactions (PMID:9058808, PMID:18288109). It was first identified through direct association with the Src-kinase substrate HS1/HCLS1 and localizes to mitochondria, ER, and the nuclear envelope (PMID:9058808). Its anti-apoptotic activity operates at multiple nodes: HAX1 inhibits caspase-9 processing (PMID:16857965), presents HtrA2/Omi to the mitochondrial protease PARL to generate the active form that restrains Bax-dependent death (PMID:18288109), stabilizes XIAP by suppressing its polyubiquitination (PMID:20171186), and limits mitochondrial permeability transition by destabilizing cyclophilin-D through an Hsp90-dependent mechanism (PMID:26553996). HAX1 maintains inner mitochondrial membrane potential, and homozygous loss-of-function mutations cause severe congenital neutropenia, with isoform-specific (transcript variant 2) expression in brain accounting for the neurological manifestations of certain mutations (PMID:17187068, PMID:18337561); mechanistically, HAX1 is required for G-CSF–triggered HCLS1 phosphorylation and downstream LEF-1 signaling in granulopoiesis, and acts within a CLPB/HAX1/HSP27 axis governing mitochondrial proteostasis and neutrophil differentiation (PMID:23001182, PMID:35499078). In the heart, HAX1 binds phospholamban and SERCA2a to inhibit cardiac calcium cycling and contractility, mediating roughly half of phospholamban's inhibitory activity, and protects against ischemia/reperfusion injury via Hsp90/IRE-1 and NOX4-linked redox mechanisms (PMID:17241641, PMID:19920172, PMID:29150445, PMID:29169992). HAX1 also drives cell migration by coupling Gα13, RhoA, Rac1, cortactin, and the microtubule end-binding protein EB2 to regulate the actin cytoskeleton and focal adhesion turnover (PMID:15339924, PMID:21518791, PMID:26527684), and as a Kv3.3 auxiliary subunit it recruits Arp2/3 to build cortical actin that controls channel inactivation in neurons (PMID:26997484). As an RNA-binding protein it binds specific 3'UTRs (vimentin, DNA polymerase beta) and shuttles between nucleus and cytoplasm via exportin-1 to influence target mRNA levels (PMID:12466525, PMID:17704138, PMID:23164465). HAX1 abundance is tightly controlled by PEST-dependent proteasomal turnover, PRKCD-directed SCF(FBXO25) ubiquitination, and EIF3H-mediated deubiquitination, the latter promoting RAF1/MEK/ERK signaling in colorectal cancer (PMID:22827267, PMID:25419709, PMID:38514606).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1997 High

    Established HAX1's existence and primary biochemical character by showing it is a mitochondrial/ER protein that directly binds the kinase substrate HS1, defining it as an intracellular adaptor.

    Evidence Yeast two-hybrid, reciprocal Co-IP, deletion mapping, and confocal microscopy

    PMID:9058808

    Open questions at the time
    • Functional consequence of HS1 binding undefined
    • No enzymatic activity identified for HAX1 itself
  2. 2002 Medium

    Identified HAX1 as a sequence-specific RNA-binding protein, opening a post-transcriptional regulatory role beyond protein scaffolding.

    Evidence Yeast three-hybrid, in vitro RNA binding, and RNA affinity pulldown for vimentin 3'UTR

    PMID:12466525

    Open questions at the time
    • Functional effect on vimentin mRNA fate not shown
    • In vivo relevance of the eEF-1gamma complex unestablished
  3. 2004 High

    Connected HAX1 to apoptotic signaling at two levels — as a protease substrate and as a migration regulator — linking it to mitochondrial death pathways and Rho-family GTPases.

    Evidence In vitro/in vivo Omi/HtrA2 cleavage assays (mnd2 mutant) and Gα13 Co-IP with siRNA migration and RhoA/Rac activity assays

    PMID:15339924 PMID:15371414

    Open questions at the time
    • Whether HAX1 cleavage is cause or consequence of death not fully resolved
    • Mechanism by which HAX1 reciprocally tunes RhoA vs Rac unclear
  4. 2006 High

    Defined HAX1's core anti-apoptotic mechanism and its disease relevance by showing caspase-9 inhibition and that loss-of-function mutations cause severe congenital neutropenia via mitochondrial dysfunction.

    Evidence Cell-free caspase activation assay and positional cloning with mitochondrial membrane potential/apoptosis assays in patient myeloid cells

    PMID:16857965 PMID:17187068

    Open questions at the time
    • How a single adaptor protects mitochondrial potential in myeloid cells specifically
    • Structural basis of caspase-9 inhibition unknown
  5. 2008 High

    Placed HAX1 within a defined mitochondrial protease module and linked it to cardiac calcium handling, while isoform analysis explained the neurological phenotype of SCN.

    Evidence Hax1 KO mouse with PARL/HtrA2 epistasis; PLN and SERCA2 domain mapping/Co-IP; SCN isoform genotype-phenotype analysis

    PMID:17241641 PMID:18288109 PMID:18337561 PMID:18971376

    Open questions at the time
    • Compartmental feasibility of the PARL interaction later disputed
    • Quantitative contribution of HAX1 to SERCA2 regulation not yet measured
  6. 2009 High

    Tested and challenged the PARL model while quantifying HAX1's role in cardiac contractility, refining where HAX1 acts within the calcium-handling apparatus.

    Evidence In vivo localization/sequence analysis arguing against PARL interaction; cardiac overexpression/knockdown with PLN ablation rescue; isoform-specific subcellular targeting by immuno-EM

    PMID:19680265 PMID:19913549 PMID:19920172

    Open questions at the time
    • Conflict over the PARL interaction (idx 17, Low) remains unreconciled
    • Lack of BH domains argues against simple Bcl-2-family classification
  7. 2010 High

    Showed HAX1 is targeted by cytotoxic-lymphocyte effector mechanisms and that its cleavage products actively drive mitochondrial depolarization, refining how its loss promotes death.

    Evidence In vitro granzyme B cleavage, uncleavable mutant overexpression, and cyclophilin-D-dependent membrane potential assays; XIAP SPR/ubiquitination assays

    PMID:20171186 PMID:20388708

    Open questions at the time
    • Physiological contexts of granzyme-B cleavage of HAX1 in vivo
    • Whether XIAP stabilization operates in the same cells as caspase-9 inhibition
  8. 2012 High

    Defined HAX1's nucleocytoplasmic shuttling and post-transcriptional functions, its degradation control, and the molecular basis of its requirement in granulopoiesis.

    Evidence NES mutagenesis/leptomycin B and P-body colocalization; PEST-deletion ubiquitination assays; HCLS1 phosphorylation/LEF-1 nuclear transport in patient cells and HCLS1-KO mouse

    PMID:22827267 PMID:23001182 PMID:23055567 PMID:23164465

    Open questions at the time
    • Signals coupling stress to HAX1 nuclear export not defined
    • How HAX1 enables HCLS1 phosphorylation mechanistically unresolved
  9. 2014 High

    Established kinase-directed, ubiquitin-mediated control of HAX1 abundance and its dimerization-dependent, isoform-specific apoptotic output, with direct relevance to lymphoma.

    Evidence PRKCD/SCF(FBXO25) ubiquitination and phosphodegron analysis in MCL models; SPR dimer kinetics with cytochrome c release and infarction assays; Rac1/cortactin domain mapping

    PMID:24347163 PMID:25053987 PMID:25419709

    Open questions at the time
    • How pro- and anti-apoptotic isoforms are balanced in normal tissues
    • Whether FBXO25 degradation of HAX1 operates outside apoptotic stress
  10. 2015 High

    Defined an Hsp90-centered chaperone-trafficking logic by which HAX1 simultaneously suppresses IRE-1 ER stress signaling and destabilizes cyclophilin-D to limit mitochondrial permeability transition.

    Evidence Cardiac overexpression and heterozygous-KO mice, HAX1/Hsp90 Co-IP, 17-AAG pharmacology, CypD ablation and mPTP/ubiquitination assays

    PMID:22982986 PMID:26553996

    Open questions at the time
    • Stoichiometry of HAX1's Hsp90 sequestration across compartments
    • How HAX1 partitions Hsp90 between IRE-1, PLN-SERCA2a, and CypD
  11. 2016 High

    Defined HAX1 as a Kv3.3 auxiliary subunit that nucleates an Arp2/3-based cortical actin network controlling channel inactivation, linking its cytoskeletal role to neuronal disease mutations.

    Evidence Co-IP, cytochalasin-D resistance, electrophysiology, and disease-mutant analysis in stem-cell-derived neurons; EB2 interactome with focal adhesion/migration assays

    PMID:26527684 PMID:26997484

    Open questions at the time
    • How HAX1 spatially couples Kv3.3, Arp2/3, and EB2 simultaneously
    • Whether neuronal actin role connects to SCN neurological phenotype
  12. 2017 High

    Quantified endogenous HAX1's contribution to cardiac calcium regulation and uncovered a redox dimension whereby HAX1 protects SERCA2a from oxidative proteolysis via NOX4.

    Evidence Cardiac-specific inducible KO with SERCA2a Ca2+-affinity and PLN-SERCA2a Co-IP; ROS/oxidation assays and HAX1/NOX4 Co-IP with NOX inhibition

    PMID:29150445 PMID:29169992

    Open questions at the time
    • Direct molecular mechanism of HAX1-NOX4 functional coupling
    • Whether redox role generalizes beyond cardiac SR
  13. 2020 High

    Extended HAX1's calcium-handling and metabolic roles to liver, identifying InsP3R1 as a partner controlling ER-mitochondria calcium transfer, mitochondrial substrate utilization, and bile acid recirculation.

    Evidence Liver-specific HAX1 KO mouse with Co-IP, calcium assays, metabolic phenotyping, and PDH activity

    PMID:32079675

    Open questions at the time
    • Whether the InsP3R1 axis operates in non-hepatic tissues
    • Mechanism linking HAX1 loss to BSEP elevation in vivo
  14. 2022 High

    Defined a CLPB/HAX1/HSP27 mitochondrial proteostasis axis that explains HAX1's requirement in neutrophil differentiation beyond its classical anti-apoptotic activity.

    Evidence SILAC proteomics in HAX1-deficient cells/mice with PRKD2/HSP27 quantification and functional HSP27 reconstitution

    PMID:35499078

    Open questions at the time
    • How HAX1 mechanistically controls mitochondrial protein turnover
    • Direct biochemical link between HAX1 and CLPB unresolved
  15. 2024 High

    Established deubiquitinase-mediated stabilization of HAX1 as an oncogenic driver, connecting HAX1 abundance control to RAF1/MEK/ERK signaling in colorectal cancer.

    Evidence EIF3H deubiquitination/Co-IP assays, conditional Eif3h-KO mouse, RAF1-MEK1-ERK1 interaction assays, and patient-derived xenografts

    PMID:38514606

    Open questions at the time
    • How HAX1 scaffolds the RAF1-MEK-ERK module mechanistically
    • Whether EIF3H-HAX1 axis operates in non-colorectal contexts

Open questions

Synthesis pass · forward-looking unresolved questions
  • How HAX1's many compartment-specific activities — mitochondrial apoptosis control, ER/SR calcium handling, cytoskeletal migration, RNA binding, and proteostasis — are integrated or selectively engaged in a given cell type remains unresolved, and no high-resolution structure of HAX1 or its complexes has been defined in this corpus.
  • No structural model of HAX1 or its interaction interfaces
  • Unclear how isoform composition dictates which functional module dominates
  • Compartmental disagreement over key interactions (e.g., PARL) not reconciled

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 6 GO:0060090 molecular adaptor activity 4 GO:0003723 RNA binding 3 GO:0140313 molecular sequestering activity 2
Localization
GO:0005739 mitochondrion 5 GO:0005783 endoplasmic reticulum 5 GO:0005654 nucleoplasm 2 GO:0005886 plasma membrane 2 GO:0005635 nuclear envelope 1
Pathway
R-HSA-5357801 Programmed Cell Death 5 R-HSA-392499 Metabolism of proteins 4 R-HSA-162582 Signal Transduction 3 R-HSA-397014 Muscle contraction 3 R-HSA-8953854 Metabolism of RNA 3 R-HSA-8953897 Cellular responses to stimuli 2
Partners
ATP2A2CTTNHCLS1HTRA2KCNC3PARLPLNXIAP
Complex memberships
Kv3.3-HAX1-Arp2/3 cortical actin complexPLN-SERCA2a complexSCF(FBXO25) ubiquitin ligase substrate

Evidence

Reading pass · 40 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 HAX-1 was identified as a novel intracellular protein that directly associates with HS1 (a substrate of Src family tyrosine kinases) via the amino-terminal region of HS1 and the carboxyl-terminal half of HAX-1; HAX-1 localizes predominantly to mitochondria but also to endoplasmic reticulum and nuclear envelope. Yeast two-hybrid screening, co-immunoprecipitation, confocal microscopy, deletion mutant analysis Journal of immunology High 9058808
2000 HAX-1 interacts with the polycystic kidney disease protein PKD2 (but not the closely related PKD2L) and also associates with the F-actin-binding protein cortactin, linking PKD2 to the actin cytoskeleton; PKD2 and HAX-1 colocalize in the cell body and in cellular processes and lamellipodia. Yeast two-hybrid screen, immunofluorescence colocalization, specificity demonstrated by failure of PKD2L to interact Proceedings of the National Academy of Sciences of the United States of America Medium 10760273
2002 KSHV K15 protein interacts with HAX-1 via its C-terminus both in vitro and in vivo; HAX-1 colocalizes with K15 at the ER and mitochondria; HAX-1 can form homodimers in vivo and functions as a potent inhibitor of apoptosis. Yeast two-hybrid screen, in vitro and in vivo binding assays, immunofluorescence colocalization, apoptosis assays Journal of virology Medium 11752170
2002 HAX-1 binds specifically to the 3' untranslated region of vimentin mRNA; HAX-1 and eEF-1gamma form protein complexes that interact with vimentin 3'UTR and can be pulled from HeLa cell extracts using a vimentin 3'UTR RNA affinity column, establishing HAX-1 as an RNA-binding protein. Yeast three-hybrid assay, in vitro RNA-protein binding, RNA affinity pulldown from cell extracts Nucleic acids research Medium 12466525
2004 HAX-1 is a specific substrate of the mitochondrial serine protease Omi/HtrA2; Omi cleaves HAX-1 both in vitro and in vivo during apoptosis; HAX-1 degradation is an early event occurring while Omi is still confined to mitochondria; inhibition of Omi protease activity prevents HAX-1 degradation and reduces cell death. In vitro cleavage assay, in vivo cleavage in cells treated with apoptotic stimuli, Omi-specific inhibitor, cell line with catalytically inactive Omi (mnd2 mice-derived) The Journal of biological chemistry High 15371414
2004 Gα13 physically interacts with HAX-1, and this interaction is required for Gα13-stimulated cell migration; HAX-1 expression reduces actin stress fibers and focal adhesion complexes in Gα13-expressing cells; HAX-1 attenuates Gα13-stimulated RhoA activity while potentiating Rac activity; a quaternary complex of Gα13, HAX-1, Rac, and cortactin was identified; siRNA-mediated silencing of HAX-1 drastically reduces Gα13-mediated cell migration. Co-immunoprecipitation, siRNA knockdown, cell migration assay, RhoA/Rac activity assays, actin/focal adhesion staining The Journal of biological chemistry High 15339924
2004 HAX-1 binds to BSEP, MDR1, and MDR2 ABC transporters; HAX-1 co-localizes with BSEP and MDR1 at the apical membrane of MDCK cells; RNAi-mediated depletion of HAX-1 increases BSEP levels in the apical membrane by 71% by enhancing retention (not by altering synthesis, modification, or delivery); HAX-1 also interacts with cortactin and participates in BSEP internalization from the apical membrane. Yeast two-hybrid, GST pulldown, co-immunoprecipitation, RNA interference, pulse-chase labeling, subcellular fractionation, immunofluorescence The Journal of biological chemistry High 15159385
2006 HAX-1 is critical for maintaining the inner mitochondrial membrane potential in myeloid cells; loss-of-function HAX1 mutations (homozygous) cause increased apoptosis in myeloid cells and severe congenital neutropenia. Positional cloning, germline mutation identification, mitochondrial membrane potential assay, apoptosis assay in patient myeloid cells Nature genetics High 17187068
2006 HAX-1 interacts with caspase-9 and inhibits caspase-9 processing in a dose-dependent manner in a cell-free caspase activation assay; HAX-1 overexpression in adult cardiac myocytes protects against apoptosis; on apoptotic stimulation, caspase-9 translocates to mitochondria and colocalizes with HAX-1. Yeast two-hybrid, cell-free caspase activation assay with recombinant protein, overexpression/siRNA knockdown in cardiac myocytes, immunofluorescence colocalization Circulation research High 16857965
2006 HAX-1 interacts with phospholamban (PLN) via PLN residues 16–22 and HAX-1 residues 203–245; binding affinity ~1 µM measured by surface plasmon resonance; phosphorylation of PLN by PKA reduces HAX-1 binding; Ca2+ diminishes PLN/HAX-1 interaction dose-dependently; HAX-1 redistributes from mitochondria to ER upon co-transfection with PLN; PLN enhances HAX-1 anti-apoptotic effects against hypoxia/reoxygenation. Yeast two-hybrid, GST pulldown, surface plasmon resonance, co-transfection/colocalization, apoptosis assay Journal of molecular biology High 17241641
2007 HAX-1 binds the 3'UTR hairpin motif of DNA polymerase beta mRNA exclusively as a dimer; disruption of the hairpin impairs RNA-protein complex formation; HAX-1 was detected in the nuclear matrix in addition to mitochondria, consistent with a role in post-transcriptional regulation. In vitro RNA binding assay, luciferase reporter system, mutagenesis of hairpin, subcellular fractionation Nucleic acids research Medium 17704138
2008 HAX-1 interacts with the mitochondrial proteases PARL and HtrA2/Omi; HAX-1 presents HtrA2 to PARL, facilitating proteolytic processing of HtrA2 to the active form in the mitochondrial intermembrane space; processed HtrA2 prevents accumulation of mitochondrial-outer-membrane-associated activated Bax, blocking apoptosis; Hax1 deficiency in mice causes apoptosis in lymphocytes and neurons. Genetic (Hax1 knockout mouse), co-immunoprecipitation, epistasis with Parl and HtrA2 mutants, Bax localization assay, apoptosis assay Nature High 18288109
2008 HAX-1 also binds to SERCA2 via SERCA2 residues 575–594 interacting with the C-terminal domain of HAX-1 (aa 203–245); HAX-1 overexpression down-regulates SERCA2 protein levels and reduces ER Ca2+ levels; SERCA2 overexpression abrogates the protective effects of HAX-1 on cell survival after hypoxia/reoxygenation; PLN co-transfection causes massive redistribution of HAX-1 to ER where it co-distributes with PLN and SERCA2. Deletion mapping, co-immunoprecipitation, cell transfection/colocalization, cell viability assay, Ca2+ measurement Molecular biology of the cell High 18971376
2008 HAX1 mutations affecting both transcript variants 1 and 2 cause severe congenital neutropenia with neurological symptoms (epilepsy, neurodevelopmental delay), while mutations affecting only transcript variant 1 cause neutropenia without neurological symptoms; transcript variant 2 is markedly expressed in human brain tissue. Mutation screening of SCN patients, genotype-phenotype analysis, tissue expression analysis of HAX1 isoforms Blood Medium 18337561
2008 HIV-1 Vpr physically associates with HAX-1; Vpr overexpression dislocates HAX-1 from mitochondria and causes mitochondrial instability and cell death; HAX-1 overexpression suppresses Vpr's pro-apoptotic activity. Co-immunoprecipitation, overexpression studies, mitochondrial localization assay, cell viability assay Journal of virology Medium 16227293
2009 HAX-1 overexpression reduces SERCA2a pump activity in isolated cardiomyocytes and in vivo, depressing calcium kinetics and contractility; conversely, HAX-1 downregulation enhances calcium cycling; HAX-1 promotes formation of PLN monomers (the active/inhibitory units of SERCA2a); ablation of PLN rescues HAX-1 inhibition of contractility in vivo, placing HAX-1 upstream of PLN in cardiac calcium regulation. Cardiac-specific overexpression mouse model, HAX-1 knockdown, calcium kinetics measurement, contractility assays, PLN monomer/pentamer analysis, genetic rescue (PLN ablation) Proceedings of the National Academy of Sciences of the United States of America High 19920172
2009 HAX-1 variant I and II localize selectively to mitochondrial membranes, while variants III, IV, and V localize to both mitochondria and sarcoplasmic reticulum; deletion of HAX-1's NH2-terminus abolishes mitochondrial targeting and attenuates anti-apoptotic capacity; removal of the PLN-binding site prevents HAX-1 translocation to SR; HAX-1 is preferentially lost from SR of PLN-deficient hearts. Immunoelectron microscopy, subcellular fractionation, deletion analysis, cellular transfection, colocalization, PLN-deficient mouse hearts Journal of molecular and cellular cardiology High 19913549
2009 HAX-1 in vivo does not interact with PARL because the two proteins are confined in distinct cellular compartments; sequence analysis shows HAX-1 lacks authentic Bcl-2 homology (BH) modules and is unlikely to be a Bcl-2 family protein; in vitro interaction between Hax1 and PARL is proposed to be an artifact. In vivo localization/fractionation, sequence analysis and secondary structure prediction Cell death and differentiation Low 19680265
2010 Granzyme B inserts into mitochondria and cleaves HAX-1 into two fragments: an N-terminal fragment that remains in mitochondria and a C-terminal fragment released to cytosol; the N-terminal fragment acts as a dominant negative, causing mitochondrial depolarization in a cyclophilin D-dependent manner; overexpression of wild-type HAX-1 or an uncleavable mutant protects against GrB-mediated depolarization. In vitro cleavage assay, mitochondrial fractionation, overexpression of cleavage mutants, membrane potential measurement, cyclophilin D dependence assay The Journal of biological chemistry High 20388708
2010 HAX-1 interacts with XIAP via HAX-1 C-terminal domain binding to XIAP BIR2 and BIR3 domains (each with affinity similar to full-length XIAP by SPR); HAX-1 suppresses polyubiquitination of XIAP, enhancing its stability and thereby inhibiting apoptosis. Proteomic screen (immunoprecipitation + 2D gel), GST pulldown, surface plasmon resonance, ubiquitination assay, cell viability assay Biochemical and biophysical research communications Medium 20171186
2011 Hax1 depletion in neutrophil-like PLB-985 cells impairs uropod detachment and directed migration; Hax1-deficient cells show increased integrin-mediated adhesion and reduced RhoA activity; RhoA depletion phenocopies Hax1 loss; activation of RhoA rescues adhesion defects in Hax1-deficient cells, placing Hax1 upstream of RhoA in regulating neutrophil adhesion and chemotaxis. siRNA knockdown, microfluidic migration assay, integrin-mediated adhesion assay, RhoA activity assay, epistasis (RhoA activation rescue) The Journal of cell biology High 21518791
2012 HAX-1 is a nucleocytoplasmic shuttling protein dependent on exportin 1 (CRM1/XPO1); two nuclear export signals (NES) were identified by systematic mutagenesis; nuclear accumulation occurs after leptomycin B treatment or specific cellular stress; HAX-1 status influences mRNA levels of DNA polymerase beta (one of its mRNA targets); HAX-1 tethering to reporter transcript decreases its expression; HAX-1 colocalizes with P-body markers. Mutagenesis of NES, leptomycin B treatment, nuclear/cytoplasmic fractionation, reporter assay, P-body colocalization The FEBS journal Medium 23164465
2012 HAX1 interacts with influenza A virus PA polymerase subunit via the nuclear localization signal (NLS) domain of PA; HAX1 knockdown increases nuclear accumulation of PA and enhances viral polymerase activity and virus yield, which can be reversed by HAX1 re-expression; thus HAX1 impedes nuclear transport of PA and restricts influenza A virus propagation. Yeast two-hybrid, GST pulldown, co-immunoprecipitation, HAX1 knockdown and rescue, nuclear fractionation, minigenome assay, virus yield assay Journal of virology High 23055567
2012 HCLS1 (HS1) is phosphorylated upon G-CSF stimulation and binds LEF-1, transporting it to the nucleus; HAX1 mutations in SCN patients impair G-CSF-triggered HCLS1 phosphorylation and reduce LEF-1 autoregulation, establishing HAX1 as required for HCLS1 phosphorylation in G-CSF signaling and granulopoiesis. Phosphorylation assays, co-immunoprecipitation, nuclear fractionation, patient myeloid cells, HCLS1-deficient mouse (neutropenic phenotype) Nature medicine High 23001182
2012 HAX-1 is rapidly degraded by the proteasome via K48-linked ubiquitination dependent on its PEST sequence; a PEST-deletion mutant of HAX-1 is more resistant to proteasomal degradation and exerts greater anti-apoptotic protection than wild-type HAX-1. PEST sequence deletion mutagenesis, ubiquitination assay, proteasome inhibitor treatment, apoptosis assay BMC cell biology Medium 22827267
2012 HAX-1 overexpression inhibits the IRE-1 ER stress signaling pathway by binding to the N-terminal fragment of Hsp90; HAX-1 sequesters Hsp90 away from IRE-1 to the PLN-SERCA2a complex; loss of HAX-1 in heterozygous-deficient hearts increases infarct size and IRE-1 activity; the Hsp90 inhibitor 17-AAG abolishes HAX-1's IRE-1 inhibitory effects. Cardiac overexpression mouse model, HAX-1 heterozygous-deficient mouse, co-immunoprecipitation (HAX-1/Hsp90), pharmacological (17-AAG), ischemia/reperfusion model Circulation research High 22982986
2013 HAX-1 variant 1 (v1) is anti-apoptotic while rat v2/human v4 is pro-apoptotic; Hax-1 isoforms form homotypic and heterotypic dimers with binding affinities ranging from ~3.8 nM (v1 homodimers) to ~97 nM (v1/v2 heterodimers); the minimal dimerization region spans aa 97-278; co-expression of v1 and v2 neutralizes both pro- and anti-apoptotic activities through modulation of cytochrome c release. SPR binding kinetics, deletion analysis, overexpression in epithelial cells, cytochrome c release assay, myocardial infarction model The Journal of biological chemistry High 24347163
2014 PRKCD (PKCδ) phosphorylates both FBXO25 and HAX-1, directing nuclear FBXO25 to mitochondrial HAX-1; FBXO25 is the substrate-recognition subunit of SCF(FBXO25) ubiquitin ligase that ubiquitinates and degrades HAX-1 after apoptotic stress; stabilizing HAX-1 phosphodegron mutations found in human MCL inhibit apoptosis; FBXO25 re-expression in FBXO25-deleted MCL cells promotes cell death. Unbiased substrate screen, co-immunoprecipitation, ubiquitination assay, phosphorylation assay, FBXO25 re-expression in MCL cells, Eµ-Myc mouse lymphoma model, xenotransplant model Nature medicine High 25419709
2014 Hax-1 is required for Rac1-cortactin interaction and colocalization in ovarian cancer cells; Hax-1 interacts with cortactin via domains aa 1-56 (Hax-D1) and aa 113-168 (Hax-D3), and with Rac1 via domains aa 57-112 (Hax-D2) and aa 169-224 (Hax-D4); silencing of Hax-1 reduces LPA-stimulated migration of SKOV3 cells and impairs Rac1-cortactin colocalization; expression of individual Hax-1 domains competitively inhibits migration. siRNA knockdown, domain mapping by deletion/truncation, co-immunoprecipitation, colocalization, cell migration assay Genes & cancer Medium 25053987
2015 HAX-1 regulates cyclophilin-D (CypD) protein levels via an Hsp90-dependent mechanism: HAX-1 overexpression interferes with CypD binding to Hsp90, rendering CypD susceptible to ubiquitin-proteasomal degradation; HAX-1 overexpression enhances CypD ubiquitination; reduced CypD decreases mPTP activation; proteasome inhibition or elevated Hsp90 rescues CypD levels in HAX-1-overexpressing cells. Cardiac-specific HAX-1 overexpression and heterozygous KO mouse models, co-immunoprecipitation, ubiquitination assay, proteasome inhibitor, genetic ablation of CypD, mPTP opening assay Proceedings of the National Academy of Sciences of the United States of America High 26553996
2015 Hax-1 interacts with microtubule end-binding protein EB2 in an EB2-specific manner; knockdown of either HAX1 or EB2 in skin epidermal cells stabilizes focal adhesions and impairs epidermal migration in vitro and in vivo; cell motility and focal adhesion turnover require the Hax1-EB2 interaction. Quantitative proteomics (EB2 interactome), co-immunoprecipitation, siRNA knockdown, focal adhesion assay, in vitro and in vivo migration assay The Journal of biological chemistry Medium 26527684
2016 Kv3.3 (KCNC3) recruits Arp2/3 to the plasma membrane via binding of its cytoplasmic C-terminus to Hax-1, forming a stable cortical actin network that prevents rapid N-type channel inactivation; a human disease-causing Kv3.3 mutation within the conserved proline-rich domain binds Hax-1 but fails to recruit Arp2/3, resulting in growth cones with deficient actin veils in stem cell-derived neurons. Co-immunoprecipitation, cytochalasin D resistance assay, electrophysiology, stem cell-derived neurons, disease mutation analysis Cell High 26997484
2017 HAX-1 ablation in the adult heart (cardiac-specific inducible KO) increases calcium affinity of SERCA2a and reduces PLN-SERCA2a binding, demonstrating that endogenous HAX-1 mediates approximately 50% of PLN's inhibitory activity on cardiac calcium cycling and contractility; PLN overexpression in HAX-1-null cardiomyocytes has no inhibitory effect, indicating HAX-1 limits PLN activity. Cardiac-specific inducible HAX-1 knockout mouse, calcium kinetics, SERCA2a Ca2+ affinity measurement, PLN-SERCA2a co-immunoprecipitation, isoproterenol stimulation, PLN overexpression rescue The Journal of biological chemistry High 29150445
2017 HAX-1 ablation in the adult heart causes increased reactive oxygen species production at the SR/ER compartment, leading to SERCA2a oxidation and enhanced proteolysis; HAX-1 interacts with NADPH oxidase 4 (NOX4), a newly identified binding partner; NOX4 inhibition abrogates the detrimental effects of HAX-1 ablation in ischemia/reperfusion injury. Cardiac-specific inducible HAX-1 KO mouse, ROS measurement, SERCA2a oxidation assay, co-immunoprecipitation (HAX-1/NOX4), NOX inhibitor (apocynin) Journal of molecular and cellular cardiology High 29169992
2018 H5N1 PB1-F2 binds to HAX-1 (a host restriction factor of IAV PA); the PA subunit of mammal-adapted H1N1 is resistant to HAX-1 restriction while avian-origin H5N1 PA remains sensitive; PB1-F2 alleviates HAX-1's inhibition of H5N1 polymerase activity through direct competition with HAX-1 for PA binding. Co-immunoprecipitation, polymerase activity assay, siRNA/overexpression of HAX-1, virus replication assay with PB1-F2-deficient mutant Journal of virology Medium 29563290
2019 HAX1 knockdown affects actomyosin contractility through changes in RhoA and septin signaling, impairing collective (but not single-cell) migration, cell-cell junctions, and cell layer integrity in breast cancer cells. HAX1 siRNA knockdown, collective/single-cell migration assays, RhoA activity assay, septin staining, cell-cell junction analysis Molecular biology of the cell Medium 31644363
2020 Hepatic HAX-1 interacts with inositol 1,4,5-trisphosphate receptor-1 (InsP3R1); HAX-1 absence reduces InsP3R1 levels, improving ER-mitochondria calcium homeostasis to prevent excess mitochondrial calcium overload; HAX-1 ablation activates pyruvate dehydrogenase and increases mitochondrial utilization of glucose and fatty acids; HAX-1 deficiency also increases bile salt exporter protein (BSEP) levels, promoting enterohepatic bile acid recirculation. Liver-specific HAX-1 KO mouse, co-immunoprecipitation, InsP3R1 quantification, calcium assays, metabolic phenotyping, pyruvate dehydrogenase activity The Journal of biological chemistry High 32079675
2021 Kv3.3 channels bind and stimulate TBK1 (TANK-binding kinase 1); TBK1 activity is required for Kv3.3 binding to its auxiliary subunit Hax-1 (which prevents channel inactivation); a disease-causing Kv3.3 mutation overactivates TBK1, leading to Hax-1 accumulation in multivesicular bodies and lysosomes, loss of Hax-1, caspase activation, and neuronal cell death. Co-immunoprecipitation, TBK1 kinase assay, dominant negative/inhibitor studies, subcellular trafficking assays, electrophysiology, caspase activity assay Nature communications High 33741962
2022 HAX1 and CLPB control the balance of mitochondrial protein synthesis and persistence (mitochondrial proteostasis) as shown by SILAC proteomics; impaired mitochondrial protein dynamics in HAX1-deficient cells are associated with decreased abundance of PRKD2 and phosphorylated HSP27 (Ser78/82); cellular defects in HAX1-/- cells can be functionally reconstituted by HSP27, defining a CLPB/HAX1/(PRKD2)/HSP27 axis critical for neutrophil granulocyte differentiation. SILAC proteomics, HAX1-deficient cells/mouse models, PRKD2 and HSP27 quantification, functional reconstitution with HSP27 The Journal of clinical investigation High 35499078
2024 EIF3H functions as a deubiquitinase for HAX1, stabilizing HAX1 by antagonizing βTrCP-mediated ubiquitination; stabilized HAX1 enhances the interaction among RAF1, MEK1, and ERK1, potentiating ERK1/2 phosphorylation and promoting colorectal cancer progression. Co-immunoprecipitation, ubiquitination assay, deubiquitination assay, conditional Eif3h deletion mouse model, RAF1-MEK1-ERK1 interaction assay, patient-derived xenografts Nature communications High 38514606

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). Nature genetics 365 17187068
2008 Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature 218 18288109
1997 HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. Journal of immunology (Baltimore, Md. : 1950) 215 9058808
2002 K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function. Journal of virology 164 11752170
2000 The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America 160 10760273
2004 Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death. The Journal of biological chemistry 152 15371414
2009 Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia. British journal of haematology 131 19775295
2004 Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1. The Journal of biological chemistry 122 15339924
2006 Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. Circulation research 121 16857965
2008 Clinical implications of ELA2-, HAX1-, and G-CSF-receptor (CSF3R) mutations in severe congenital neutropenia. British journal of haematology 101 19120359
2009 HAX-1: a multifunctional protein with emerging roles in human disease. Biochimica et biophysica acta 99 19524642
2008 The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival. Molecular biology of the cell 92 18971376
2004 Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. The Journal of biological chemistry 92 15159385
2008 Novel HAX1 mutations in patients with severe congenital neutropenia reveal isoform-dependent genotype-phenotype associations. Blood 91 18337561
2006 Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function. Journal of molecular biology 88 17241641
2012 Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Nature medicine 73 23001182
2008 Central nervous system involvement in severe congenital neutropenia: neurological and neuropsychological abnormalities associated with specific HAX1 mutations. Journal of internal medicine 70 18513342
2005 Human immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1. Journal of virology 69 16227293
2002 The 3' untranslated region of human vimentin mRNA interacts with protein complexes containing eEF-1gamma and HAX-1. Nucleic acids research 69 12466525
2016 MicroRNA-223 Increases the Sensitivity of Triple-Negative Breast Cancer Stem Cells to TRAIL-Induced Apoptosis by Targeting HAX-1. PloS one 68 27618431
2012 Novel role of HAX-1 in ischemic injury protection involvement of heat shock protein 90. Circulation research 68 22982986
2015 HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart. Proceedings of the National Academy of Sciences of the United States of America 65 26553996
2016 Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating. Cell 61 26997484
2010 HAX-1 overexpression, splicing and cellular localization in tumors. BMC cancer 60 20196840
2014 Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis. Nature medicine 53 25419709
2009 The anti-apoptotic protein HAX-1 is a regulator of cardiac function. Proceedings of the National Academy of Sciences of the United States of America 51 19920172
2013 Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis. Haematologica 49 23975175
2012 Cellular protein HAX1 interacts with the influenza A virus PA polymerase subunit and impedes its nuclear translocation. Journal of virology 49 23055567
2001 Epstein-Barr virus nuclear antigen 5 interacts with HAX-1, a possible component of the B-cell receptor signalling pathway. The Journal of general virology 47 11413368
2008 Neurodevelopmental abnormalities associated with severe congenital neutropenia due to the R86X mutation in the HAX1 gene. Journal of medical genetics 46 18611981
2003 HAX-1, identified by differential display reverse transcription polymerase chain reaction, is overexpressed in lesional psoriasis. The Journal of investigative dermatology 46 12787133
2011 HAX-1: a family of apoptotic regulators in health and disease. Journal of cellular physiology 45 21302289
2016 Inhibition of HAX-1 by miR-125a reverses cisplatin resistance in laryngeal cancer stem cells. Oncotarget 44 27880721
2016 Clinical and biological significance of HAX-1 overexpression in nasopharyngeal carcinoma. Oncotarget 43 26871467
2011 Hax1 regulates neutrophil adhesion and motility through RhoA. The Journal of cell biology 43 21518791
2009 Hax1 lacks BH modules and is peripherally associated to heavy membranes: implications for Omi/HtrA2 and PARL activity in the regulation of mitochondrial stress and apoptosis. Cell death and differentiation 42 19680265
2007 Hairpin structure within the 3'UTR of DNA polymerase beta mRNA acts as a post-transcriptional regulatory element and interacts with Hax-1. Nucleic acids research 42 17704138
2017 miR-125b regulates the drug-resistance of breast cancer cells to doxorubicin by targeting HAX-1. Oncology letters 40 29434858
2022 HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation. The Journal of clinical investigation 38 35499078
2022 Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation. Journal of extracellular vesicles 38 35524442
2010 Molecular interaction between HAX-1 and XIAP inhibits apoptosis. Biochemical and biophysical research communications 38 20171186
2010 Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage. The Journal of biological chemistry 38 20388708
2001 Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein. Cytokine 37 11554782
2011 Hax-1: a regulator of calcium signaling and apoptosis progression with multiple roles in human disease. Expert opinion on therapeutic targets 35 21391832
2012 HAX-1 is a nucleocytoplasmic shuttling protein with a possible role in mRNA processing. The FEBS journal 34 23164465
2015 HAX-1 inhibits apoptosis in prostate cancer through the suppression of caspase-9 activation. Oncology reports 31 26323553
2018 miR-100 Reverses Cisplatin Resistance in Breast Cancer by Suppressing HAX-1. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 30 29975932
2016 Kostmann's Disease and HCLS1-Associated Protein X-1 (HAX1). Journal of clinical immunology 30 27943080
2015 Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice. Acta pharmacologica Sinica 30 26299953
2009 Hepatitis C virus core protein and cellular protein HAX-1 promote 5-fluorouracil-mediated hepatocyte growth inhibition. Journal of virology 29 19605487
2009 Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1. Blood 29 19620402
2007 Association of HAX1 deficiency with neurological disorder. Neuropediatrics 29 18330843
2012 Hax-1 is rapidly degraded by the proteasome dependent on its PEST sequence. BMC cell biology 28 22827267
2010 The classical swine fever virus N-terminal protease N(pro) binds to cellular HAX-1. The Journal of general virology 28 20631090
2006 Identification and expression analysis of alternative splice variants of the rat Hax-1 gene. Gene 27 16516414
2019 Upregulation of let-7f-2-3p by long noncoding RNA NEAT1 inhibits XPO1-mediated HAX-1 nuclear export in both in vitro and in vivo rodent models of doxorubicin-induced cardiotoxicity. Archives of toxicology 26 31570982
2017 HAX-1 regulates SERCA2a oxidation and degradation. Journal of molecular and cellular cardiology 26 29169992
2015 Regulation of Focal Adhesion Dynamics and Cell Motility by the EB2 and Hax1 Protein Complex. The Journal of biological chemistry 26 26527684
2009 HAX-1: a multifaceted antiapoptotic protein localizing in the mitochondria and the sarcoplasmic reticulum of striated muscle cells. Journal of molecular and cellular cardiology 26 19913549
2008 An anti-apoptotic protein, Hax-1, inhibits the HIV-1 rev function by altering its sub-cellular localization. Journal of cellular physiology 26 17929250
2007 Severe developmental delay and epilepsy in a Japanese patient with severe congenital neutropenia due to HAX1 deficiency. Haematologica 26 18055975
2024 The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression. Nature communications 25 38514606
2019 HAX-1 promotes the migration and invasion of hepatocellular carcinoma cells through the induction of epithelial-mesenchymal transition via the NF-κB pathway. Experimental cell research 25 31047882
2016 KDM4B plays an important role in mitochondrial apoptosis by upregulating HAX1 expression in colorectal cancer. Oncotarget 25 27506941
2010 HAX1 mutations causing severe congenital neuropenia and neurological disease lead to cerebral microstructural abnormalities documented by quantitative MRI. American journal of medical genetics. Part A 25 21108402
2010 Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton. BMC cell biology 24 20406461
2009 Induction of apoptosis by Hax-1 siRNA in melanoma cells. Cell biology international 24 19254774
2015 Expression of HAX-1 in colorectal cancer and its role in cancer cell growth. Molecular medicine reports 23 26062578
2011 hSav1 interacts with HAX1 and attenuates its anti-apoptotic effects in MCF-7 breast cancer cells. International journal of molecular medicine 23 21567072
2021 Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1. Nature communications 22 33741962
2016 Endoplasmic reticulum (ER) stress triggers Hax1-dependent mitochondrial apoptotic events in cardiac cells. Apoptosis : an international journal on programmed cell death 22 27654581
2012 HAX-1 promotes the chemoresistance, invasion, and tumorigenicity of esophageal squamous carcinoma cells. Digestive diseases and sciences 22 22451114
2019 Homozygous c.130-131 ins A (pW44X) mutation in the HAX1 gene as the most common cause of congenital neutropenia in Turkey: Report from the Turkish Severe Congenital Neutropenia Registry. Pediatric blood & cancer 21 31321910
2018 H5N1 Influenza A Virus PB1-F2 Relieves HAX-1-Mediated Restriction of Avian Virus Polymerase PA in Human Lung Cells. Journal of virology 21 29563290
2013 Competition through dimerization between antiapoptotic and proapoptotic HS-1-associated protein X-1 (Hax-1). The Journal of biological chemistry 21 24347163
2010 HAX1 deficiency: impact on lymphopoiesis and B-cell development. European journal of immunology 21 20865787
2006 Expression and tissue distribution of mouse Hax1. Gene 21 16814492
2017 Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells. Blood advances 20 29296734
2014 Neurological findings and genetic alterations in patients with Kostmann syndrome and HAX1 mutations. Pediatric blood & cancer 20 24482108
2014 Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration. Genes & cancer 20 25053987
2013 Expression of HAX-1 in human colorectal cancer and its clinical significance. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20 24057929
2013 Hax-1 identified as a two-pore channel (TPC)-binding protein. FEBS letters 20 24188827
2008 Homozygous HAX1 mutations in severe congenital neutropenia patients with sporadic disease: a novel mutation in two unrelated British kindreds. British journal of haematology 20 19036076
2017 The antiapoptotic protein HAX-1 mediates half of phospholamban's inhibitory activity on calcium cycling and contractility in the heart. The Journal of biological chemistry 19 29150445
2017 HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway. Frontiers in cellular neuroscience 19 29311840
2015 HAX-1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation. International journal of clinical and experimental pathology 18 26339377
2010 A novel HAX1 gene mutation in severe congenital neutropenia (SCN) associated with neurological manifestations. European journal of pediatrics 17 20182745
2020 HAX1 enhances the survival and metastasis of non-small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway. Thoracic cancer 16 32926529
2018 Critical Role of HAX-1 in Promoting Avian Influenza Virus Replication in Lung Epithelial Cells. Mediators of inflammation 16 29576744
2008 Necrosis of nasal cartilage due to mucormycosis in a patient with severe congenital neutropenia due to HAX1 deficiency. Journal of investigational allergology & clinical immunology 16 19123440
2020 Hepatic HAX-1 inactivation prevents metabolic diseases by enhancing mitochondrial activity and bile salt export. The Journal of biological chemistry 15 32079675
2020 miR-654-5p Targets HAX-1 to Regulate the Malignancy Behaviors of Colorectal Cancer Cells. BioMed research international 15 32104694
2019 HAX1 impact on collective cell migration, cell adhesion, and cell shape is linked to the regulation of actomyosin contractility. Molecular biology of the cell 15 31644363
2014 Exploring the anti-apoptotic role of HAX-1 versus BCL-XL in cytokine-dependent bone marrow-derived cells from mice. FEBS letters 15 24910348
2021 A zebrafish model for HAX1-associated congenital neutropenia. Haematologica 14 32327498
2017 Delayed Puberty and Gonadal Failure in Patients with HAX1 Mutation. Journal of clinical immunology 14 28681255
2014 Clinical significance of HAX-1 expression in laryngeal carcinoma. Auris, nasus, larynx 14 25554539
2012 HAX1 Augments Cell Proliferation, Migration, Adhesion, and Invasion Induced by Urokinase-Type Plasminogen Activator Receptor. Journal of oncology 14 22315598
2010 Traumatic brain injury induces an up-regulation of Hs1-associated protein X-1 (Hax-1) in rat brain cortex. Neurochemical research 14 21136158
2015 HAX-1: a novel p-body protein. DNA and cell biology 13 25289648

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