Affinage

FGF10

Fibroblast growth factor 10 · UniProt O15520

Length
208 aa
Mass
23.4 kDa
Annotated
2026-06-09
100 papers in source corpus 55 papers cited in narrative 53 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FGF10 is a mesenchyme-derived paracrine ligand that orchestrates epithelial outgrowth, branching morphogenesis, and progenitor maintenance across many developing organs by signaling to receptor-bearing epithelium (PMID:9916808, PMID:9428423, PMID:11062007). Loss of FGF10 abolishes lung branching and causes complete limb truncation with failure of the apical ectodermal ridge and zone of polarizing activity, and its broader null phenotype—loss of thyroid, pituitary, salivary, lacrimal, and other glands—closely mirrors that of FGFR2b-null mice, establishing FGF10 as the principal ligand for the FGFR2b receptor isoform (PMID:9916808, PMID:11062007, PMID:10821755). Acting on isolated lung endoderm, FGF10 induces directed chemotaxis, proliferation, and multi-bud outgrowth, and its activity strictly requires heparan sulfate co-factors whose 2-O-, 6-O-, and N-sulfation patterns assemble the FGF10–FGFR2b–HS ternary complex on the cell surface and gate downstream ERK signaling (PMID:9428423, PMID:12781692, PMID:18230614, PMID:21357686). Signal transduction proceeds chiefly through the Grb2-SOS/Ras/RAF/ERK MAPK cascade—dissectable by dominant-negative Ras and pathway inhibitors—and through PI3K/Akt in some contexts, with negative feedback imposed by FGF10-induced Sprouty2 (PMID:12533312, PMID:28981091, PMID:12225946). FGF10 controls cell fate as well as growth: it sustains Notch activation to block endocrine differentiation in pancreatic progenitors, limits BMP4 action both transcriptionally and through FGF10-induced cathepsin H proteolysis during lung branching, and regulates regional cardiomyocyte proliferation via a FOXO3/p27kip1 axis (PMID:10821767, PMID:14517990, PMID:16323074, PMID:17500053, PMID:25344367). FGF10 transcription is governed by an upstream regulatory network including ISL1 (acting at a conserved intronic enhancer with GATA4/TBX20), Tbx4/Tbx5, Gli3, Gata3, retinoic acid, and NF-κB/SP3-mediated repression (PMID:22303449, PMID:12399308, PMID:12588840, PMID:16720875, PMID:16806848, PMID:15328022, PMID:23558680). Beyond development, FGF10 supports adult tissue homeostasis and repair, maintaining airway basal stem cell niches through Wnt-Hippo-controlled stromal Fgf10 expression, driving beige adipocyte differentiation via autocrine FGF10-FGFR2 signaling, and promoting cardiomyocyte cell-cycle re-entry after injury (PMID:29017029, PMID:29233981, PMID:34755840). Loss-of-function FGF10 mutations causing haploinsufficiency underlie LADD syndrome (PMID:17682060).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1997 High

    Established FGF10 as a mesenchymal signal that instructs epithelial behavior, distinguishing it functionally from related FGFs by its ability to drive directional budding rather than mere expansion.

    Evidence Embryonic lung endoderm culture in Matrigel with recombinant FGF10, transgenic Shh-overexpressing lungs, in situ hybridization

    PMID:9428423

    Open questions at the time
    • Receptor identity not defined in this study
    • Intracellular signaling pathway not yet dissected
  2. 1999 High

    Demonstrated that FGF10 is genetically essential for organogenesis, answering whether it is dispensable or required by showing complete loss of lungs and limbs in nulls.

    Evidence Fgf10-/- knockout mouse with marker gene expression analysis

    PMID:9916808

    Open questions at the time
    • Does not resolve receptor or co-factor requirements
    • Cell-autonomous vs paracrine action not separated
  3. 2000 High

    Assigned FGF10 as the major in vivo ligand for FGFR2b by showing its multi-organ null phenotype phenocopies the FGFR2b null, defining ligand-receptor specificity at the organismal level.

    Evidence Fgf10 knockout organ phenotype survey compared with FGFR2b-/- mice; gain/loss-of-function in lacrimal, dental, and skin systems

    PMID:10821755 PMID:10984614 PMID:11062007 PMID:11066089

    Open questions at the time
    • Biochemical demonstration of direct FGF10-FGFR2b binding not addressed here
    • Receptor isoform usage in individual organs not exhaustively mapped
  4. 2000 High

    Resolved how FGF10 outgrowth is spatially constrained by identifying BMP4 as an FGF10-induced antagonist, building a feedback module that shapes branching.

    Evidence Isolated lung endoderm with FGF-loaded beads, Bmp4-lacZ reporter, exogenous BMP4 and Noggin

    PMID:10821767

    Open questions at the time
    • Mechanism linking FGF10 to BMP4 induction not defined at this stage
    • Whether antagonism is direct or relayed unresolved
  5. 2002 High

    Defined FGF10 as a stem/progenitor survival factor and uncovered intracellular negative feedback, showing both that FGF10 prevents apoptosis in the incisor niche and that it induces Sprouty2 to dampen its own MAPK output.

    Evidence Anti-FGF10 neutralizing antibody and recombinant rescue in organ culture; mSpry2 overexpression with Co-IP and MAP kinase assay in lung epithelial cells

    PMID:11880361 PMID:12225946

    Open questions at the time
    • Sprouty2 binding partner study is single-lab Co-IP
    • Quantitative contribution of feedback to morphogenesis not established
  6. 2003 High

    Mechanistically dissected FGF10 signaling and its heparan sulfate dependence, showing ERK activation via Grb2-SOS/Ras/RAF protects epithelium and that defined HS sulfation patterns gate the local budding response.

    Evidence MAPK pathway inhibitors and dominant-negative Ras in alveolar cells; HS sulfation mapping and inhibitor treatment in lung culture; redundancy and lineage analyses in otic, inner ear, pancreas, and limb systems

    PMID:12399308 PMID:12533312 PMID:12761848 PMID:12781692 PMID:12810586 PMID:14517990

    Open questions at the time
    • Structural basis of the FGF10-FGFR2b-HS complex not yet solved here
    • Contribution of PI3K branch versus MAPK not separated
  7. 2004 Medium

    Profiled the FGF10 transcriptional response and metabolic/regulatory inputs, revealing target genes for cell rearrangement/migration and identifying retinoic acid as a maintainer of respiratory-field Fgf10.

    Evidence Global gene expression profiling of FGF10-budding lung explants; RAR antagonist in foregut explants and vitamin A deficiency; Ras/MAPK pathway analysis in preadipocytes

    PMID:15130516 PMID:15328022 PMID:15556938

    Open questions at the time
    • Direct versus indirect target distinction limited
    • Single-lab transcriptome screen
  8. 2007 Medium

    Identified cathepsin H as the post-transcriptional effector by which FGF10 controls mature BMP4 availability, converting the earlier FGF10–BMP4 genetic relationship into a defined proteolytic mechanism.

    Evidence FGF10 target screen with cathepsin H inhibitor in lung culture and BMP4 immunostaining; FGFR2-IIIb pancreatic cancer migration/invasion assays

    PMID:17500053 PMID:18594526

    Open questions at the time
    • Direct enzymatic cleavage of BMP4 by cathepsin H not biochemically reconstituted
    • Cancer-stromal FGF10 role from single cell-line study
  9. 2008 High

    Provided biochemical resolution of the HS co-factor requirement, showing that decasaccharides with specific sulfation codes selectively drive proliferation versus morphogenetic outputs through FGFR2b and FGFR1b.

    Evidence HS-deficient BaF3/FGFR2b proliferation assay with defined synthetic decasaccharide libraries and primary salivary epithelium culture

    PMID:18230614

    Open questions at the time
    • In vivo HS sulfation gradients not directly manipulated here
    • How distinct sulfation codes are generated spatially unaddressed
  10. 2011 High

    Validated the HS sulfation requirement in vivo and at the level of ternary complex assembly, showing 6-O-sulfation is needed for FGF10-FGFR2b-HS complex formation and ERK signaling in lacrimal development.

    Evidence Conditional Hs2st/Hs6st ablation, cell-surface complex formation assay, ERK assay, and lacrimal explant induction; Barx2 and Cx43 dependence of FGF10-induced ERK

    PMID:21357686 PMID:21750040 PMID:26565022

    Open questions at the time
    • Atomic structure of the signaling complex not determined
    • Generality of Cx43 gap-junction requirement across organs untested
  11. 2012 High

    Connected FGF10 to human disease and defined the cardiac transcriptional enhancer driving its expression, establishing ISL1 (with GATA4/TBX20) as a direct activator and LADD mutations as haploinsufficient loss-of-function.

    Evidence ISL1 ChIP, EMSA, luciferase reporter, and transgenic enhancer assays; functional comparison of FGF10 LADD mutant proteins; FGF9-Pitx2-Fgf10 conditional KO epistasis

    PMID:17682060 PMID:22303449 PMID:22819677

    Open questions at the time
    • LADD mutant biochemistry from single lab
    • Full upstream enhancer logic across other organs not mapped
  12. 2019 High

    Resolved receptor- and pathway-specific logic in the lung, showing FGF10-FGFR2b uses MAPK to promote proliferation/differentiation while FGF9-FGFR3 uses PI3K to oppose it, defining a ligand-receptor-pathway-function map.

    Evidence Receptor-specific conditional KO, selective inhibitors, and PI3K/MAPK pathway and fate-marker analysis in lung epithelium

    PMID:32127497

    Open questions at the time
    • Whether the same receptor-pathway split applies in other FGF10 target organs untested
  13. 2022 High

    Extended FGF10 biology into adult homeostasis and regeneration, revealing a developmental-to-epithelial source switch in salivary ionocytes and Hippo/Meis1-linked cardiac repair functions.

    Evidence scRNA-seq and inducible lineage tracing in salivary gland; Fgf10+/- and conditional overexpression post-MI with Hippo/Meis1 and metabolic profiling

    PMID:34755840 PMID:35417692

    Open questions at the time
    • Functional role of epithelial ionocyte-derived FGF10 not fully defined
    • Cardiac Hippo/Meis1 mechanism from single-lab study

Open questions

Synthesis pass · forward-looking unresolved questions
  • How distinct heparan sulfate sulfation codes, receptor isoform choice, and FGF10 source (mesenchymal vs epithelial) are integrated to select between proliferation, chemotaxis, survival, and fate-specification outputs in a given tissue remains unresolved.
  • No atomic structure of FGF10-FGFR2b-HS complex in the timeline
  • Quantitative rules linking signal duration/strength to specific cell-fate outputs unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 5 GO:0060089 molecular transducer activity 3
Localization
GO:0005576 extracellular region 3
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-162582 Signal Transduction 3
Partners
FGFR1FGFR2

Evidence

Reading pass · 53 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 FGF10 is essential for lung branching morphogenesis and limb outgrowth; Fgf10-/- mice die at birth lacking lungs (pulmonary branching fails after tracheal formation) and have complete fore- and hindlimb truncation. In mutant limb buds, the apical ectodermal ridge (AER) and zone of polarizing activity (ZPA) fail to form. Knockout mouse (Fgf10-/- loss-of-function), marker gene expression analysis Nature genetics High 9916808
1997 FGF10 expressed dynamically in distal lung mesenchyme acts on lung endoderm to induce chemotaxis, epithelial cell proliferation, and bud outgrowth; FGF10-treated isolated endoderm in Matrigel progresses to multiple buds (unlike FGF7 which only induces expansion). High SHH in endoderm downregulates Fgf10 in mesenchyme. Embryonic lung tissue culture in Matrigel/collagen gel, isolated endoderm culture with recombinant FGF10, transgenic Shh-overexpressing lungs, in situ hybridization Development (Cambridge, England) High 9428423
2000 FGF10 acts as the major ligand for FGFR2b in multi-organ development. Analysis of Fgf10-/- mice revealed absence of thyroid, pituitary, and salivary glands, with minor defects in teeth, kidneys, hair follicles, and digestive organs — a phenotypic spectrum closely matching FGFR2b-null mice. Fgf10 knockout mouse analysis, organ phenotype comparison with FGFR2b-/- mice Biochemical and biophysical research communications High 11062007
2000 FGF10 induces both proliferation and chemotaxis of isolated lung endoderm and upregulates BMP4 expression in endoderm closest to FGF10 source; exogenous BMP4 inhibits FGF10-induced budding/chemotaxis and proliferation, while BMP-binding protein Noggin enhances FGF10-induced morphogenesis — placing BMP4 as an antagonist downstream of FGF10 signaling. In vitro lung endoderm culture with FGF-loaded beads in Matrigel, Bmp4-lacZ reporter mice, exogenous BMP4 and Noggin addition Development (Cambridge, England) High 10821767
2000 FGF10 is sufficient to stimulate ectopic lacrimal gland bud formation from conjunctival epithelium in ocular explants; FGF10 is required for lacrimal gland induction (absent in Fgf10-/- mice); in mesenchyme-free gland epithelium, FGF10 stimulates growth but not branching, indicating its inductive role is primarily mitogenic. Pax6 acts as a competence factor for FGF10-induced lacrimal bud formation. FGF10 bead application to ocular explants, Fgf10-/- mouse analysis, receptor inhibition (FGFR2 IIIb dominant-negative), mesenchyme-free epithelium culture Development (Cambridge, England) High 10821755
2000 FGF10 stimulates cell proliferation in the dental epithelium but not in the mesenchyme; dental mesenchymal Fgf10 expression depends on dental epithelium signals, and epithelial FGF4 and FGF8 induce Fgf3 but not Fgf10 expression in isolated dental mesenchyme. In vitro FGF protein application to tooth explants, tissue recombination culture, bead soaking with FGFs/BMPs/Shh Developmental dynamics Medium 11066089
2000 FGF10 is required for embryonic epidermal morphogenesis; Fgf10-/- newborn skin shows decreased basal layer proliferation, hypoplastic granular layer lacking keratohyaline granules, and dramatically reduced loricrin expression. Hair follicle development is not affected. Fgf10-/- mouse histological analysis, loricrin immunostaining FEBS letters Medium 10984614
2001 Transgenic overexpression of FGF10 in fetal lung causes adenomatous malformations, perturbed branching morphogenesis, and respiratory failure at birth; postnatal FGF10 expression induces reversible multifocal pulmonary adenomas with type II cell differentiation (TTF-1+, SP-C+, CCSP-). Tumor regression occurs upon doxycycline withdrawal. Doxycycline-inducible transgenic mice (SP-C and CCSP promoter-driven FGF10), immunostaining for differentiation markers American journal of physiology. Lung cellular and molecular physiology Medium 11238011
2002 FGF10 is a survival factor for the stem cell population in the developing incisor cervical loop; neutralizing anti-FGF10 antibody induces apoptosis in the cervical loop in organ culture, and recombinant FGF10 rescues apoptosis. In Fgf10-/- mice, cervical loop fails to form due to divergence of Fgf10 and Fgf3 expression at E16. Fgf10-/- mouse analysis, anti-FGF10 neutralizing antibody in organ culture, recombinant FGF10 rescue experiment, apoptosis assay Development (Cambridge, England) High 11880361
2002 Tbx5 functions downstream of WNT signaling to regulate Fgf10 expression, and Fgf10 in turn maintains Tbx5 expression during limb outgrowth — establishing a Tbx5-Fgf10 feedback loop. Tbx5 and Wnt2b function together to initiate forelimb outgrowth. Zebrafish and chick embryo gain- and loss-of-function experiments, mutant analyses Development (Cambridge, England) High 12399308
2002 mSprouty2 (mSpry2), induced in lung epithelium by FGF10, negatively regulates FGF10-activated MAP kinase signaling; FGF10 stimulation causes mSpry2 tyrosine phosphorylation and differential binding to upstream MAP kinase pathway proteins (increased association with Grb2, SNT2, and Raf; decreased binding to PTP2 and GAP1), resulting in net reduction of MAP kinase activation. mSpry2 also translocates to the plasma membrane in response to FGF10. Overexpression of mSpry2 in mouse lung epithelial cells (MLE15), co-immunoprecipitation, subcellular localization imaging, MAP kinase activation assay American journal of physiology. Lung cellular and molecular physiology Medium 12225946
2003 Fgf10 and Fgf3 are redundantly required for otic vesicle formation; mice lacking both Fgf3 and Fgf10 fail to form otic vesicles with aberrant otic marker gene expression, while single mutants show milder phenotypes. FGF signals act directly on the ectoderm to establish normal gene expression patterns, without affecting hindbrain gene expression. Fgf3/Fgf10 double knockout mice, in situ hybridization of otic marker genes, cell proliferation and survival analysis Development (Cambridge, England) High 12810586 14623822
2003 FGF10 maintains Notch activation in pancreatic progenitors, stimulates epithelial cell proliferation, and blocks differentiation. Persistent FGF10 in transgenic pancreas inhibits neurogenin3 (ngn3) expression, thereby blocking endocrine differentiation. Notch pathway activation is required downstream of FGF10 signaling for progenitor maintenance. Transgenic mice with persistent Fgf10 expression in pancreas, gamma-secretase inhibitor to block Notch, explant cultures of pancreatic epithelium, marker gene expression analysis Developmental dynamics High 14517990 16323074
2003 Heparan sulfate (HS) modulates FGF10-FGFR2b-induced lung morphogenesis; HS low in O-sulfates is expressed in lung mesenchyme at sites of prospective budding near Fgf10-expressing areas, while highly sulfated HS is in epithelial basement membranes. Disrupting HS gradients prevents FGF10 local budding responses. O-sulfated groups (particularly 6-O-sulfates) in HS are critical for FGF10 signaling activation. HS expression mapping, embryonic lung culture with heparin sulfate inhibitors, selectively sulfated heparin treatment Developmental biology Medium 12781692
2003 Tbx4 in visceral mesoderm activates Fgf10 expression to induce lung bud formation in chick; ectopic Tbx4 induces ectopic bud formation in esophagus via Fgf10 activation, and interference with Tbx4 represses Fgf10 and prevents lung bud formation. Ectopic Tbx4 or Fgf10 induces Nkx2.1 in esophageal endoderm. In ovo electroporation for ectopic Tbx4 expression in chick, dominant-negative Tbx4 interference, marker gene expression analysis Development (Cambridge, England) Medium 12588840
2003 FGF10 null mutants show complete agenesis of the posterior semicircular canal crista and canal; posterior canal sensory neurons form initially at E11.5 but disappear within 2 days. FGF10 is required for morphogenesis of the anterior and horizontal canals/cristae but not for organ of Corti cellular development. Fgf10-/- mouse inner ear analysis, in situ hybridization, histology at multiple embryonic stages Developmental dynamics Medium 12761848
2003 FGF10 protects alveolar epithelial cells (AEC) against cyclic stretch-induced DNA damage via MAPK activation through the Grb2-SOS/Ras/RAF-1/ERK1/2 pathway; MAPK inhibitors and dominant-negative Ras prevent FGF10-induced ERK1/2 phosphorylation and abolish its protective effects. Cyclic stretch of AEC, FGF10 pretreatment, MAPK inhibitors (Grb2-SOS inhibitor, RAS inhibitor, RAF-1 inhibitor), dominant-negative RAS cells (N17-A549), DNA strand break assay American journal of physiology. Lung cellular and molecular physiology Medium 12533312
2004 Retinoic acid (RA) selectively maintains mesodermal Fgf10 expression in the prospective lung field; RAR antagonist (BMS493) in foregut explant cultures blocks lung bud initiation by preventing Fgf10 induction specifically in the respiratory mesoderm — not in thyroid or pancreas mesoderm. RA also maintains Ttf1 and Sp-C expression in lung endoderm. Foregut explant culture with pan-RAR antagonist BMS493, in situ hybridization, vitamin A deficiency in vivo rat model Developmental biology Medium 15328022
2004 Global FGF10 transcriptional targets in lung epithelium during budding include genes associated with cell rearrangement, cell migration, inflammatory processes, and lipid metabolism (but not cell proliferation at initial budding stages). Cathepsin H (Ctsh) is induced by FGF10 in epithelium. Global gene expression profiling of lung epithelial explants undergoing FGF10-mediated budding, in situ hybridization validation, FGF10 protein bead application to intact lungs The Journal of biological chemistry Medium 15556938
2004 In white adipose tissue (WAT), Fgf10 is required for preadipocyte proliferation and adipogenesis; Fgf10-/- WAT shows greatly decreased C/EBPβ and PPARγ expression (but not C/EBPα). FGF10 stimulates preadipocyte proliferation through Ras/MAPK pathway followed by cyclin D2-dependent phosphorylation of p130; FGF10 also induces pRb expression (required for adipogenesis) through Ras/MAPK. Fgf10-/- mouse WAT analysis, mouse embryonic fibroblast culture with FGF10 + MAPK inhibitor, western blotting for cell cycle proteins Molecular and cellular endocrinology Medium 15130516
2005 Fgf10-expressing cells in distal lung mesenchyme are progenitors of parabronchial smooth muscle cells (PSMCs); FGF10 is required for mesenchymal progenitor entry into the PSMC lineage. FGF10 fails to phosphorylate ERK and AKT in lung mesenchymal cultures, indicating FGF10 acts indirectly on PSMC progenitors via an epithelial intermediate. Epithelial BMP4 mediates PSMC formation downstream. Fgf10-lacZ lineage reporter transgenic mice, Fgf10 hypomorphic mutants, alpha-SMA immunostaining, ERK/AKT phosphorylation assay in mesenchymal cultures Development (Cambridge, England) Medium 15800000
2005 Wnt5a regulates FGF10 signaling in lung development; Wnt5a overexpression in epithelium increases mesenchymal Fgf10 and decreases Shh. Cultured mesenchyme-free epithelial explants from SpC-Wnt5a transgenic lungs respond abnormally to FGF10 (dilated tips) and show inhibited chemotaxis toward directional FGF10 source, suggesting Wnt5a disrupts epithelial FGF10 response. SpC-Wnt5a transgenic mice, mesenchyme-free epithelial explant culture with recombinant FGF10, directional FGF10 chemotaxis assay Developmental biology Medium 16169547
2005 FGF10/FGFR2b signaling is essential for submandibular salivary gland (SMG) epithelial branching, cell proliferation, and histodifferentiation, but not earliest initial bud formation. Dose-dependent phenotypes (hypoplasia in heterozygotes, aplasia in nulls) demonstrate haploinsufficiency. FGF8/FGFR2c can rescue reduced FGF10/FGFR2b signaling in vitro for branching. Fgf10 and Fgfr2b heterozygous and null mouse analysis, double heterozygous compound mutants, in vitro rescue with FGF8 BMC developmental biology Medium 15972105
2006 Gli3 co-regulates somitic Fgf10 expression gradients required for mammary placode formation; somitic FGF10 is required for induction of mammary placodes 2 and 3, and recombinant FGF10 can rescue mammogenesis in Fgf10-/- and Gli3 mutant flanks. Fgf10-/- mouse, Gli3Xt-J/Xt-J mutant, Pax3ILZ/ILZ mutant analysis, Fgf10 hypomorphic mutants, recombinant FGF10 rescue in flank explants Development (Cambridge, England) Medium 16720875
2006 FGF10 stimulates preadipocyte proliferation in white adipose tissue via the Ras/MAPK pathway causing cyclin D2 expression and p130 phosphorylation; Ras/MAPK pathway inhibition blocks FGF10-stimulated cyclin D2 and p130 phosphorylation in mouse embryonic fibroblasts. Fgf10-/- WAT analysis, mouse embryonic fibroblast treatment with FGF10, Ras/MAPK inhibitor, western blotting for cyclin D2 and retinoblastoma family protein phosphorylation Molecular and cellular endocrinology Medium 16513252
2006 FGF10 in the second heart field marks cardiac progenitors that give rise to the outflow tract and right ventricle; Fgf10-expressing progenitor cells contribute to these structures via normal mechanisms. Fgf10-/- mice show abnormal heart positioning but not outflow tract formation defects, while FGFR2b-/- mice show outflow tract/ventricular septal defects. Fgf10 and Fgfr2b mutant cardiac phenotype analysis, histology, scanning electron microscopy, gene/transgene expression studies Cardiovascular research Medium 16687131
2006 FGF10 controls stomach progenitor maintenance and morphogenesis; ectopic FGF10 expression in posterior stomach disrupts the glandular proliferative niche, causes aberrant gland formation, and attenuates endocrine and parietal cell differentiation. These effects correlate with changes in Hes1, Shh, and Wnt6 expression. pPDX-FGF10(FLAG) transgenic mice with ectopic gastric FGF10, marker gene expression analysis Developmental biology Medium 17196193
2007 Fgf10 signaling from adjacent mesenchyme refines boundaries between hepatopancreatic duct and organs in zebrafish; in fgf10 mutants, hepatopancreatic ductal epithelium is severely dysmorphic and ductal/intestinal cells misdifferentiate toward hepatic and pancreatic fates. Fgf10 prevents differentiation of proximal pancreas and liver into hepatic and pancreatic cells. Zebrafish fgf10 mutant analysis, marker gene expression for fate determination Nature genetics Medium 17259985
2007 Gata3 is required upstream of Fgf10 expression in the inner ear; Gata3 deficiency leads to loss of Fgf10 expression in otic epithelium and auditory ganglion, suggesting Gata3 is an important transcriptional regulator of Fgf10 during otic development. Gata3-/- mouse inner ear analysis, in situ hybridization for Fgf10 and otic markers Mechanisms of development Medium 16806848
2007 Cathepsin H (Ctsh) is selectively induced by FGF10 in lung epithelium and controls availability of mature BMP4 protein during branching morphogenesis. Inhibiting Ctsh activity leads to BMP4 protein accumulation and disruption of branching morphogenesis, revealing a posttranscriptional mechanism by which FGF10 limits BMP4 action. Global FGF10 target screen, Ctsh inhibitor treatment in embryonic lung cultures, BMP4 immunostaining, branching morphogenesis readout The Journal of biological chemistry Medium 17500053
2007 FGF10 signals through FGFR2-IIIb (a specific isoform) to induce migration and invasion of pancreatic cancer cells; FGF10 also induces MT1-MMP mRNA expression and TGF-β1 mRNA/protein secretion from pancreatic cancer cell lines. FGFR2 is expressed in cancer cells while FGF10 is in surrounding stroma. FGFR2-IIIb-expressing pancreatic cancer cell lines (CFPAC-1, AsPC-1), FGF10 treatment, migration/invasion assays, mRNA/protein analysis for MT1-MMP and TGF-β1 British journal of cancer Medium 18594526
2008 Specific heparan sulfate (HS) structures modulate FGF10-mediated salivary gland morphogenesis: HS with at least 10 saccharides and 6-O-, 2-O-, and N-sulfates are required for maximal FGF10/FGFR2b-driven cell proliferation. Decasaccharides with 2-O-sulfation + N- or 6-O-sulfation induce end bud expansion (via FGFR1b), while 6-O-sulfation alone induces duct elongation. HS-deficient BaF3/FGFR2b cell proliferation assay, defined heparin decasaccharide libraries, primary SMG epithelium culture, FGFR1b signaling analysis The Journal of biological chemistry High 18230614
2009 Conditional inactivation of Fgf10 in lung mesenchyme results in smaller lobes with reduced branch number and increased cell death; inactivation of Fgfr2 in lung epithelium disrupts lobes and causes arbitrary small epithelial outgrowths. Both genes alter expression of key signaling molecules and expand a proximal lung marker distally. Conditional KO using Cre-lox in lung mesenchyme (Fgf10) and epithelium (Fgfr2), branching analysis, marker gene expression, cell death quantification Developmental dynamics Medium 19618463
2009 ISL1 directly occupies a conserved binding site in the FGF10 first intron enhancer and activates FGF10 transcription in the cardiac second heart field (SHF); GATA4 and TBX20 enhance ISL1-mediated transcription from this element. ChIP and EMSA demonstrate direct ISL1 occupancy. ChIP of ISL1 on FGF10 intronic enhancer, EMSA, luciferase reporter assay, transgenic mice with human FGF10 intronic enhancer driving reporter, co-transfection with GATA4/TBX20 PloS one High 22303449
2009 FGF8 and FGF10 from second heart field mesoderm functionally overlap in formation of the outflow tract/right ventricle and pharyngeal arch arteries; compound Fgf8;Fgf10 mesodermal mutants show increased severity of OFT/RV defects and pharyngeal arch artery phenotypes compared to single mutants, revealing dosage sensitivity. MesP1Cre-mediated mesodermal compound Fgf8;Fgf10 conditional knockouts, cardiac morphology analysis Circulation research Medium 20035084
2009 Fgf10 Apert syndrome gain-of-function (via FGFR2 AS mutation) is mediated in part by FGF10; genetic knockdown of Fgf10 rescues skeletal and some visceral defects in AS mice and restores near-normal FGFR2 signaling with a switch from ERK(p44/p42) to p38 phosphorylation. FGF10 knockdown in AS background unexpectedly causes de novo cleft palate and blind colon. Fgf10 deficiency crossed into FGFR2 Apert syndrome mouse model, Western blotting for ERK/p38 phosphorylation, skeletal/histological analysis Developmental dynamics Medium 18773495
2010 FGF10 controls tracheal cartilage ring patterning via Shh; precise spatiotemporal levels of FGF10 expression in ventral mesenchyme between E11.5-E13.5 allow periodic Shh expression in the ventral epithelium which in turn patterns cartilage rings. Both gain and loss of FGF10 perturb cartilage ring patterning. FGF10 gain- and loss-of-function transgenic approaches in trachea, SHH expression analysis, cartilage ring phenotype quantification Development (Cambridge, England) Medium 21148187
2011 6-O-sulfation of heparan sulfate (via Hs6st1/Hs6st2) is critical for FGF10-FGFR2b signaling during lacrimal gland development; combined Hs2st;Hs6st deficiency completely abolishes lacrimal gland development, disrupts Fgf10-Fgfr2b-HS ternary complex formation on cell surface, and prevents FGF10 downstream ERK signaling. Conditional genetic ablation of Hs2st, Hs6st1, Hs6st2 in lacrimal gland, genetic interaction analysis with Fgf10, cell surface complex formation assay, ERK phosphorylation assay, explant lacrimal gland induction assay The Journal of biological chemistry High 21357686
2011 Barx2 is required for Fgf10-induced lacrimal gland bud elongation; Barx2 cooperates with Fgf10 in regulation of matrix metalloproteinases (MMPs). Barx2-/- lacrimal glands show decreased MMP expression and defective epithelial cell migration through ECM. Barx2-/- mouse, ex vivo antisense assays, FGF10-induced LG bud elongation assay in Barx2-/- tissue, MMP expression analysis Development (Cambridge, England) Medium 21750040
2011 Connexin 43 (Cx43) is required for FGF10-induced ERK1/2 phosphorylation in salivary epithelial cells; gap junction inhibitors (18α-GA, oleamide) and Cx43 knockdown/blocking peptide inhibit FGF10-induced ERK1/2 phosphorylation in epithelium but not PDGF-induced ERK1/2 in mesenchyme. FGF10 does not rescue Cx43-/- salivary gland phenotype. Cx43-/- mice, gap junction inhibitors, siRNA knockdown, FGF10 treatment of HSY cells, ERK1/2 phosphorylation western blotting The Journal of biological chemistry Medium 26565022
2012 FGF9 signals through mesenchymal Pitx2 to induce mesenchymal Fgf10 expression, which in turn leads to epithelial cecal bud formation; epithelial-specific and mesenchymal-specific conditional Fgf9 and Pitx2 knockouts establish this epistatic cascade for cecal formation. Tissue compartment-specific conditional knockouts for Fgf9 and Pitx2, cecal formation analysis, marker gene expression Developmental biology Medium 22819677
2012 LADD syndrome FGF10 mutations are loss-of-function mutations causing haploinsufficiency; three different FGF10 LADD mutants show severely impaired biological activities by different molecular mechanisms. FGFR2 LADD mutants have strongly compromised tyrosine kinase activity and may exert dominant-negative effects via receptor dimerization. Functional comparison of FGF10 LADD mutant proteins vs. wild-type, FGFR2 LADD mutant tyrosine kinase activity assays in transfected cells Molecular and cellular biology Medium 17682060
2013 NF-κB activation suppresses FGF10 expression through RELA-SP3 interactions at the Fgf10 promoter; SP3 co-expression reduces SP1-mediated Fgf10 promoter activity. ChIP of LPS-treated fetal lung mesenchymal cells shows increased RELA-SP3 interactions at the Fgf10 promoter, and constitutively active IKKβ decreases Fgf10 promoter activity while increasing RELA-SP3 nuclear interactions. Luciferase reporter assay, ChIP on fetal lung mesenchymal cells, IKKβ constitutively active mutant, dominant-negative IκB, co-expression studies The Journal of biological chemistry Medium 23558680
2014 FGF10 regulates regional cardiomyocyte proliferation in the fetal heart via a FOXO3/p27kip1 pathway; Fgf10-/- hearts show impaired right ventricular but not left ventricular myocyte proliferation with decreased FOXO3 phosphorylation and upregulated p27kip1. Fgf10 and Fgfr2b are expressed in cardiomyocytes (not fibroblasts), supporting cell-autonomous action. FGF10 overexpression in adult mice promotes cardiomyocyte cell-cycle re-entry. Fgf10-/- heart analysis, primary cardiomyocyte cultures, cell-type-specific gene expression (cardiomyocytes vs. fibroblasts), FOXO3/p27kip1 western blotting, in vivo Fgf10 overexpression in adult mice Cardiovascular research Medium 25344367
2014 Stromal Fgf10 acts as a paracrine mediator for estradiol-dependent uterine epithelial proliferation; siRNA knockdown of Fgf10 in stromal layer inhibits E2-induced epithelial proliferation in co-culture and abrogates E2-regulated epithelial receptor signaling. Uterine epithelial-stromal co-culture, microarray gene expression, siRNA knockdown, in situ hybridization, receptor signaling analysis Molecular and cellular endocrinology Medium 25451979
2015 Fgf10 is required for specification of non-sensory regions of the cochlea (Reissner's membrane and outer sulcus); Fgf10-/- embryos show shortened and narrowed cochlear duct lacking Reissner's membrane and outer sulcus without changes in epithelial cell proliferation or death. Fgf10+/- embryos show dosage-sensitive reduction/absence of posterior semicircular canal. Fgf10-/- and Fgf10+/- mouse cochlear analysis, marker gene expression at multiple stages, cell proliferation/death assays Developmental biology Medium 25624266
2017 FGF10 activates neuronal FGFR2/PI3K/Akt signaling to reduce apoptosis and repair neurites after spinal cord injury; FGF10 also inhibits microglia/macrophage activation through TLR4/NF-κB pathway. FGFR2 siRNA knockdown suppresses PI3K/Akt activation by FGF10 and abolishes its anti-apoptotic effects in vitro. LY294002 (PI3K inhibitor) partially reverses FGF10 therapeutic effects. Spinal cord injury mouse model, exogenous FGF10 treatment, FGFR2 siRNA knockdown, PI3K inhibitor (LY294002), apoptosis assays, neurite analysis Cell death & disease Medium 28981091
2017 β-adrenergic stimulation upregulates FGF10 levels and promotes preadipocyte differentiation into beige adipocytes via FGF10-FGFR2 autocrine signaling; miR-327 targets FGF10 to prevent beige adipocyte differentiation. In vivo local delivery of miR-327 to WAT compromises beige phenotype and thermogenesis; systemic miR-327 inhibition induces browning. miR-327 gain/loss-of-function in mice, FGF10 target validation, in vivo WAT miR-327 delivery, metabolic rate measurement Nature communications Medium 29233981
2017 During lung homeostasis, basal stem cells (BSCs) in cartilaginous airways maintain stem cell state by downregulating the Hippo pathway (nuclear Yap), which generates a localized Fgf10-expressing stromal niche. After injury, epithelial Wnt7b is secreted (via integrin-linked kinase/Merlin/Hippo pathway) and induces Fgf10 expression in airway smooth muscle cells (ASMCs) to extend the BSC niche. Fgf10-iCre lineage tracing, Hippo pathway manipulation, Wnt7b conditional expression, ILK and Merlin pathway analysis, BSC functional assays Developmental cell Medium 29017029
2017 Dlx5 controls FGF10 pathway expression in the oropharyngeal region; loss of Dlx5 leads to downregulation of FGF10 signaling, and activation of FGF10 signaling rescues cranial neural crest cell proliferation and myogenic differentiation in Dlx5 mutant mice. Dlx5-/- mouse analysis, FGF10 pathway activation rescue experiment, proliferation/apoptosis analysis of CNC and muscle progenitor cells Development (Cambridge, England) Medium 28982687
2019 FGF10 and FGF9 activate distinct signaling pathways in lung epithelium with opposing functions: FGF10 signals through FGFR2b using predominantly MAPK pathways to promote epithelial proliferation and differentiation, while FGF9 signals through FGFR3 using PI3K pathways to promote distal fate specification and inhibit differentiation. FGF9-FGFR3 functionally opposes FGF10-FGFR2b signaling. Conditional KO of FGFR3 and FGFR2b in lung epithelium, selective receptor inhibitors, PI3K and MAPK pathway analysis, epithelial cell fate marker analysis Science signaling High 32127497
2022 FGF10 promotes cardiac repair via two mechanisms: enhancing cardiomyocyte proliferation and preventing myofibroblast activation/fibrosis after MI. FGF10 activates the Hippo signaling pathway, regulates Meis1 expression, and promotes a pro-glycolytic metabolic switch. Fgf10 levels are upregulated in the injured ventricle post-MI, and Fgf10+/- mice show impaired post-MI cardiomyocyte proliferation and enhanced fibrosis. Fgf10+/- mice post-MI, conditional Fgf10 overexpression post-MI, cardiomyocyte proliferation assay, fibrosis analysis, Hippo/Meis1 pathway analysis, metabolic profiling Cardiovascular research Medium 34755840
2022 FGF10 expression switches from exclusive mesenchymal origin (until postnatal day 5) to epithelial origin (after P7-P15) in salivary glands; the epithelial FGF10-positive cells are specialized ionocytes expressing Foxi1, Foxi2, Ascl3, and CFTR, located in ducts and involved in ionic modification of saliva. These ionocytes maintain homeostasis via communication with FGFR2b+ ductal and myoepithelial cells. Single-cell RNA sequencing, tamoxifen-inducible Fgf10CreERT2:R26-tdTomato lineage tracing, RNA-seq of sorted mesenchymal and epithelial FGF10+ cells Cell reports High 35417692

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1999 Fgf10 is essential for limb and lung formation. Nature genetics 974 9916808
1997 Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development (Cambridge, England) 797 9428423
2000 FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochemical and biophysical research communications 496 11062007
2000 Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. Development (Cambridge, England) 403 10821767
2003 Fgf3 and Fgf10 are required for mouse otic placode induction. Development (Cambridge, England) 239 12810586
2000 Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis. Developmental dynamics : an official publication of the American Association of Anatomists 209 11066089
2003 Expression and function of FGF10 in mammalian inner ear development. Developmental dynamics : an official publication of the American Association of Anatomists 205 12761848
2002 FGF10 maintains stem cell compartment in developing mouse incisors. Development (Cambridge, England) 188 11880361
2002 The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10. Development (Cambridge, England) 183 12399308
2000 FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development (Cambridge, England) 177 10821755
2003 Requirements for FGF3 and FGF10 during inner ear formation. Development (Cambridge, England) 172 14623822
1999 Prostatic growth and development are regulated by FGF10. Development (Cambridge, England) 165 10409514
2007 Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nature genetics 164 17259985
2003 Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells. Developmental dynamics : an official publication of the American Association of Anatomists 161 14517990
2005 Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development (Cambridge, England) 149 15800000
2005 Wnt5a regulates Shh and Fgf10 signaling during lung development. Developmental biology 147 16169547
2017 Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury. Cell death & disease 144 28981091
2001 FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo. American journal of physiology. Lung cellular and molecular physiology 135 11238011
2009 Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung. Developmental dynamics : an official publication of the American Association of Anatomists 133 19618463
2013 Fgf10-positive cells represent a progenitor cell population during lung development and postnatally. Development (Cambridge, England) 127 24353064
2008 FGF10/FGFR2 signal induces cell migration and invasion in pancreatic cancer. British journal of cancer 125 18594526
2007 Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Developmental biology 124 17560563
2005 FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC developmental biology 120 15972105
2003 Tbx4-Fgf10 system controls lung bud formation during chicken embryonic development. Development (Cambridge, England) 111 12588840
2003 Heparan sulfate-FGF10 interactions during lung morphogenesis. Developmental biology 105 12781692
2017 Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells. Developmental cell 102 29017029
2006 Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development (Cambridge, England) 102 16720875
2004 Retinoic acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut. Developmental biology 97 15328022
2002 mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteins. American journal of physiology. Lung cellular and molecular physiology 97 12225946
2009 Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circulation research 93 20035084
2018 Fgf10 Signaling in Lung Development, Homeostasis, Disease, and Repair After Injury. Frontiers in genetics 88 30319693
2008 Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. The Journal of biological chemistry 87 18230614
2018 The lncRNA TUG1/miR-145-5p/FGF10 regulates proliferation and migration in VSMCs of hypertension. Biochemical and biophysical research communications 85 29758198
2006 Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice. Cardiovascular research 83 16687131
2007 Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. Developmental biology 82 17601531
2008 Progesterone regulates FGF10, MET, IGFBP1, and IGFBP3 in the endometrium of the ovine uterus. Biology of reproduction 79 18753603
2015 FGF10: A multifunctional mesenchymal-epithelial signaling growth factor in development, health, and disease. Cytokine & growth factor reviews 77 26559461
2014 Lung epithelial stem cells and their niches: Fgf10 takes center stage. Fibrogenesis & tissue repair 77 24891877
2010 FGF10 controls the patterning of the tracheal cartilage rings via Shh. Development (Cambridge, England) 77 21148187
2011 Lacrimal gland development and Fgf10-Fgfr2b signaling are controlled by 2-O- and 6-O-sulfated heparan sulfate. The Journal of biological chemistry 70 21357686
2016 Neuron-derived FGF10 ameliorates cerebral ischemia injury via inhibiting NF-κB-dependent neuroinflammation and activating PI3K/Akt survival signaling pathway in mice. Scientific reports 68 26813160
1999 FGF7 and FGF10 directly induce the apical ectodermal ridge in chick embryos. Developmental biology 67 10373311
2011 Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling. Development (Cambridge, England) 65 21750040
2006 FGF10 signaling controls stomach morphogenesis. Developmental biology 64 17196193
2004 Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis. The Journal of biological chemistry 64 15556938
2007 FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias. European journal of human genetics : EJHG 60 17264867
2006 Gata3 is required for early morphogenesis and Fgf10 expression during otic development. Mechanisms of development 58 16806848
2018 FGF10 Protects Against Renal Ischemia/Reperfusion Injury by Regulating Autophagy and Inflammatory Signaling. Frontiers in genetics 56 30532765
2006 Interplay between FGF10 and Notch signalling is required for the self-renewal of pancreatic progenitors. The International journal of developmental biology 56 16323074
2014 FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry. Cardiovascular research 55 25344367
2017 A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning. Nature communications 53 29233981
2016 Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia. The Journal of pathology 53 27770432
2007 Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway. Molecular and cellular biology 53 17682060
2018 Regulation of FGF10 Signaling in Development and Disease. Frontiers in genetics 49 30405705
2020 Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice. European journal of nutrition 48 32808060
2015 Fgf10 is required for specification of non-sensory regions of the cochlear epithelium. Developmental biology 48 25624266
2014 Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a. Molecular and cellular endocrinology 48 25451979
2020 FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching. Science signaling 46 32127497
2000 Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene. FEBS letters 46 10984614
2019 Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling. Development (Cambridge, England) 45 30651296
2005 Identification of cis-element regulating expression of the mouse Fgf10 gene during inner ear development. Developmental dynamics : an official publication of the American Association of Anatomists 44 15765517
2019 FGF10 Enhances Peripheral Nerve Regeneration via the Preactivation of the PI3K/Akt Signaling-Mediated Antioxidant Response. Frontiers in pharmacology 43 31680984
2009 Evidence that Fgf10 contributes to the skeletal and visceral defects of an Apert syndrome mouse model. Developmental dynamics : an official publication of the American Association of Anatomists 43 18773495
2020 TBBPA, TBBPS, and TCBPA disrupt hESC hepatic differentiation and promote the proliferation of differentiated cells partly via up-regulation of the FGF10 signaling pathway. Journal of hazardous materials 42 32653787
2014 Fgf10: a paracrine-signaling molecule in development, disease, and regenerative medicine. Current molecular medicine 41 24730525
2011 Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development. Developmental biology 41 21664901
2008 Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis. Molecular and cellular neurosciences 41 18329286
2003 FGF-10 prevents mechanical stretch-induced alveolar epithelial cell DNA damage via MAPK activation. American journal of physiology. Lung cellular and molecular physiology 40 12533312
2012 ISL1 directly regulates FGF10 transcription during human cardiac outflow formation. PloS one 37 22303449
2011 Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10. Breast cancer research : BCR 37 21767389
2013 Interactions between NF-κB and SP3 connect inflammatory signaling with reduced FGF-10 expression. The Journal of biological chemistry 35 23558680
2011 The interaction of epithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladder development. Developmental biology 35 21925490
2014 FGF10: Type III Epithelial Mesenchymal Transition and Invasion in Breast Cancer Cell Lines. Journal of Cancer 34 25057305
2009 Mechanisms for split localization of Fgf10 expression in early lung development. Developmental dynamics : an official publication of the American Association of Anatomists 34 19842186
2006 Role of Fgf10 in cell proliferation in white adipose tissue. Molecular and cellular endocrinology 34 16513252
2004 Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo. Molecular and cellular endocrinology 34 15130516
2018 Fibroblast growth factor 10 (FGF10) promotes the adipogenesis of intramuscular preadipocytes in goat. Molecular biology reports 33 30250994
2011 FGF10 and FGF21 as regulators in adipocyte development and metabolism. Endocrine, metabolic & immune disorders drug targets 32 21696361
2022 A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands. Cell reports 31 35417692
2018 FGF10 Signaling in Heart Development, Homeostasis, Disease and Repair. Frontiers in genetics 30 30546382
2013 c-Myc regulates proliferation and Fgf10 expression in airway smooth muscle after airway epithelial injury in mouse. PloS one 30 23967208
2017 Potential involvement of Fgf10/Fgfr2 and androgen receptor (AR) in renal fibrosis in adult male rat offspring subjected to prenatal exposure to di-n-butyl phthalate (DBP). Toxicology letters 29 28919491
2022 FGF10 promotes cardiac repair through a dual cellular mechanism increasing cardiomyocyte renewal and inhibiting fibrosis. Cardiovascular research 28 34755840
2017 The Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development. Development (Cambridge, England) 28 28982687
2012 FGF10 inhibits dominant follicle growth and estradiol secretion in vivo in cattle. Reproduction (Cambridge, England) 28 22457435
2021 Fgf10/Fgfr2b Signaling Orchestrates the Symphony of Molecular, Cellular, and Physical Processes Required for Harmonious Airway Branching Morphogenesis. Frontiers in cell and developmental biology 27 33511132
2021 FGF10 and Lipofibroblasts in Lung Homeostasis and Disease: Insights Gained From the Adipocytes. Frontiers in cell and developmental biology 27 34124037
2019 Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia. Human molecular genetics 27 30566624
2019 MicroRNA-421 inhibition alleviates bronchopulmonary dysplasia in a mouse model via targeting Fgf10. Journal of cellular biochemistry 27 31144392
2013 FGF10 Signaling differences between type I pleuropulmonary blastoma and congenital cystic adenomatoid malformation. Orphanet journal of rare diseases 27 24004862
2009 Conditional control of the differentiation competence of pancreatic endocrine and ductal cells by Fgf10. Mechanisms of development 27 19969077
2015 Connexin 43 Is Necessary for Salivary Gland Branching Morphogenesis and FGF10-induced ERK1/2 Phosphorylation. The Journal of biological chemistry 26 26565022
2018 FGF10 and Human Lung Disease Across the Life Spectrum. Frontiers in genetics 25 30429870
2013 A functional polymorphism at the FGF10 gene is associated with extreme myopia. Investigative ophthalmology & visual science 25 23599340
2012 FGF9-Pitx2-FGF10 signaling controls cecal formation in mice. Developmental biology 25 22819677
2020 Fgf10/Fgfr2b Signaling in Mammary Gland Development, Homeostasis, and Cancer. Frontiers in cell and developmental biology 24 32676501
2007 Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis. The Journal of biological chemistry 24 17500053
2021 Vascular Adventitial Fibroblasts-Derived FGF10 Promotes Vascular Smooth Muscle Cells Proliferation and Migration in vitro and the Neointima Formation in vivo. Journal of inflammation research 23 34079328
2013 Bladder cancer cell in co-culture induces human stem cell differentiation to urothelial cells through paracrine FGF10 signaling. In vitro cellular & developmental biology. Animal 23 23949743
2005 Tissue-specific expression of Fgfr2b and Fgfr2c isoforms, Fgf10 and Fgf9 in the developing chick mandible. Archives of oral biology 23 16105644

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