Affinage

FGFBP1

Fibroblast growth factor-binding protein 1 · UniProt Q14512

Length
234 aa
Mass
26.3 kDa
Annotated
2026-06-09
45 papers in source corpus 25 papers cited in narrative 25 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FGFBP1 is a secreted heparin-binding chaperone that mobilizes matrix-sequestered fibroblast growth factors to enable paracrine FGF signaling: purified recombinant protein directly binds FGF-2, releases it from the extracellular matrix, and stimulates endothelial and tumor cell proliferation and chemotaxis in an FGF-2-dependent manner (PMID:11304685), with heparin/heparan-sulfate binding mediated by a basic cluster at residues 110–143 (PMID:9784842). By controlling FGF availability, FGFBP1 acts across vascular, neuromuscular, and tumor contexts. In the vasculature it sensitizes resistance vessels and renal afferent arterioles to angiotensin II constriction through FGF receptor kinase–dependent crosstalk integrated by MKK4/p38/JNK MAPK signaling, an effect lost in FGF2-null mice and restored by FGF2 plus FGFBP1 add-back, and sufficient to raise arterial blood pressure when transgenically expressed (PMID:29158353); this same FGF2/FGFBP1 axis underlies brain vascular angiotensin II sensitization following acute kidney injury (PMID:33040621). In brain endothelium FGFBP1 acts cell-autonomously to concentrate Wnt ligands at junctions, promoting Wnt/β-catenin-driven blood-brain barrier maturation and collagen IV basement-membrane deposition (PMID:32747434), and it is concentrated at neuromuscular junctions by muscle fibers, where its loss produces structural NMJ defects and accelerates degeneration in an ALS model (PMID:28053031). FGFBP1 transcription is a convergence point for numerous inputs, being activated by STAT3 (PMID:34341336, PMID:42013958), C/EBP via ERK/p38 (PMID:11313920), KLF5 (PMID:38087142), and Sp1 downstream of SGCE (PMID:37838174), and repressed by vitamin D/VDR through NF-κB (PMID:23104116, PMID:24938357) and by CREB3L1, which is itself targeted by miR-146a (PMID:27121396); in cancers it drives proliferation, migration, and invasion via downstream FGF-FGFR, AKT, and SNAIL2/KLK10 signaling (PMID:32195034, PMID:34117747, PMID:38087142). Beyond FGF mobilization, FGFBP1 acts as an extracellular ligand that drives F-actin rearrangement and maintains keratinocyte cobblestone morphology in a HAI-1-dependent manner (PMID:37076641).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 1998 Medium

    Localizing the heparin-binding determinant established how FGFBP1 physically docks onto the heparan-sulfate matrix where FGFs are sequestered.

    Evidence Protease peptide mapping and heparin-Sepharose affinity isolation of binding fragments

    PMID:9784842

    Open questions at the time
    • No mutagenesis validation of the 110–143 cluster
    • Does not address FGF-binding site location
    • Single lab
  2. 2001 High

    Reconstitution with purified protein answered whether FGFBP1 directly binds and mobilizes FGF-2, establishing it as a paracrine FGF chaperone rather than an autonomous growth factor.

    Evidence In vitro binding, ECM release, proliferation/chemotaxis assays with antibody neutralization

    PMID:11304685

    Open questions at the time
    • Stoichiometry and structure of the FGFBP1–FGF complex not resolved
    • Receptor-level consequences not directly measured
  3. 2001 Medium

    Mapping the serum-responsive promoter elements defined the kinase cascades and transcription factors that drive FGFBP1 expression, distinguishing it from EGF-driven induction.

    Evidence Promoter deletion/mutagenesis, kinase inhibitors, run-on assay in SCC cells

    PMID:11313920

    Open questions at the time
    • Direct C/EBP binding not shown by ChIP
    • Single cell-type context
  4. 2005 Medium

    Identification of FGFBP1 as a phosphoacceptor for PKA, CK1, and CK2 raised the possibility that phosphorylation tunes its FGF/lactoferrin-binding behavior.

    Evidence In vitro kinase assays and binding affinity measurements on milk-purified bovine ortholog

    PMID:16412577 PMID:17560725

    Open questions at the time
    • Phosphoregulation not demonstrated in vivo in human FGFBP1
    • Physiological role of milk-derived fragments unclear
  5. 2010 Medium

    Zebrafish knockdown tested whether FGFBP1 is developmentally essential and whether all its functions route through FGF2, revealing an FGF2-independent survival requirement.

    Evidence Morpholino knockdown with cell-death assays compared to fgf2 morphants

    PMID:20396962

    Open questions at the time
    • Morpholino off-target effects not excluded by genetic mutant
    • Molecular basis of FGF2-independent survival role undefined
  6. 2014 Medium

    Vitamin D/VDR/NF-κB suppression of FGFBP1 was linked functionally to reduced FGF-2 secretion, confirming FGFBP1 as required for FGF-2 release in living cells.

    Evidence Luciferase reporter, VDR siRNA, immunofluorescence, and FGF-2 ELISA in OSCC cells

    PMID:23104116 PMID:24938357

    Open questions at the time
    • Direct NF-κB occupancy of FGFBP1 promoter not shown
    • Single tumor-cell context
  7. 2016 Medium

    The miR-146a/CREB3L1 axis was defined as a repressive layer controlling FGFBP1-dependent FGF2 secretion and angiogenesis.

    Evidence FGFBP1 promoter luciferase, ChIP, CREB3L1 manipulation, and FGF2 ELISA in HUVECs

    PMID:27121396

    Open questions at the time
    • In vivo relevance of this axis not established
    • Single endothelial model
  8. 2017 High

    Genetic knockout established a physiological, FGF-mobilizing role for FGFBP1 in maintaining neuromuscular junction integrity, and identified TGF-β1 as a suppressing input under muscle stress.

    Evidence FGFBP1 KO and SOD1G93A ALS mice, NMJ structural and survival analysis, TGF-β1 treatment

    PMID:28053031

    Open questions at the time
    • Which FGF(s) mediate the NMJ effect not pinned down
    • Mechanism of FGFBP1 concentration at the synapse unresolved
  9. 2017 High

    An inducible transgenic and FGF2-null rescue strategy demonstrated that FGFBP1 controls blood pressure by sensitizing vessels to angiotensin II through FGF receptor–MAPK crosstalk, defining a cardiovascular function.

    Evidence Inducible BP1 transgenic and FGF2−/− mice, telemetry, isolated vessel pharmacology, FGFR/ROS inhibitors

    PMID:29158353

    Open questions at the time
    • Molecular point of FGFR–AngII receptor convergence not structurally defined
    • Cell type driving vessel sensitization not isolated
  10. 2020 High

    Conditional endothelial knockout revealed a distinct FGF-independent-looking role: concentrating Wnt ligands to drive blood-brain barrier maturation and basement-membrane assembly.

    Evidence Endothelial-specific Fgfbp1 KO mice, tracer leakage, Plvap/collagen IV staining, in vitro Wnt localization

    PMID:32747434

    Open questions at the time
    • Direct FGFBP1–Wnt binding not biochemically demonstrated
    • How a heparin-binding chaperone localizes Wnt versus FGF unresolved
  11. 2020 High

    Knockout and protein add-back extended the AngII-sensitization mechanism to a kidney–brain vascular axis, showing FGFBP1 mediates inter-organ vascular crosstalk after acute kidney injury.

    Evidence Renal ischemia-reperfusion model, Fgfbp1 KO mice, vessel constriction with FGF2/FGFBP1 add-back, FGFR inhibitor

    PMID:33040621

    Open questions at the time
    • Signal carrying FGFBP1 induction from kidney to brain not defined
    • Human relevance inferential
  12. 2019 Medium

    Cancer studies placed FGFBP1 within oncogenic signaling, downstream of FBW7/c-Myc and HSD11B2, and upstream of AKT/FGFR/SNAIL2/KLK10 effectors driving proliferation and metastasis.

    Evidence Epistatic knockdown/rescue, co-culture, ChIP/luciferase, and xenograft assays across pancreatic, colorectal, esophageal, and breast cancer models

    PMID:31911852 PMID:32195034 PMID:34117747 PMID:37838174 PMID:38087142 PMID:40233428

    Open questions at the time
    • Direct physical interactions among most named effectors not demonstrated
    • Cancer-type-specific wiring not unified mechanistically
  13. 2021 Medium

    ChIP-level evidence defined STAT3 as a direct activator of FGFBP1, downstream of mTORC1, linking inflammatory/airway stimuli to FGFBP1-driven angiogenesis.

    Evidence STAT3 ChIP on FGFBP1 promoter, rapamycin inhibition, angiogenesis assay, OVA asthma model

    PMID:34341336

    Open questions at the time
    • Single airway context
    • Downstream FGF target of secreted FGFBP1 not specified
  14. 2023 Medium

    Mass-spectrometry-guided rescue revealed an FGF-independent activity of FGFBP1 as an extracellular ligand maintaining keratinocyte cytoskeleton and morphology via HAI-1.

    Evidence HAI-1 KO HaCaT cells, conditioned-medium and recombinant FGFBP1 rescue, tandem MS, F-actin imaging

    PMID:37076641

    Open questions at the time
    • Receptor mediating the HAI-1-dependent response not identified
    • Direct FGFBP1–HAI-1 binding not shown
  15. 2025 Medium

    An ERK-ATF3 and liquid-liquid phase separation framework was proposed for how FGF6 tunes FGFBP1 release kinetics and how circulating FGFBP1 engages hepatic FGF5 during liver regeneration.

    Evidence Multi-omics, muscle-GR and Fgf6 knockout mice, LLPS/condensate assays, serum FGFBP1 ELISA in patients

    PMID:40685360

    Open questions at the time
    • LLPS-driven release not independently replicated
    • Structural basis of condensate formation undefined
  16. 2026 Medium

    Knockout plus pharmacological inhibition established FGFBP1 as a STAT3-dependent effector of angiotensin II-driven pathological cardiac remodeling.

    Evidence FGFBP1 KO mice in AngII/TAC models, RNA-seq, STAT3 inhibitor S3I-201, cardiac histology

    PMID:42013958

    Open questions at the time
    • FGF effector mediating cardiac hypertrophy not identified
    • Cell-type-specific source of FGFBP1 in heart not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how a single heparin-binding chaperone selectively mobilizes distinct ligand classes (FGF-1/2, FGF22, FGF5, Wnt) in different tissues and which receptor mediates its FGF-independent cytoskeletal activity.
  • No structure of FGFBP1 in complex with any ligand
  • Mechanism distinguishing FGF- versus Wnt-mobilizing modes unknown
  • Receptor for FGF-independent signaling unidentified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 3 GO:0008289 lipid binding 2 GO:0048018 receptor ligand activity 1
Localization
GO:0005576 extracellular region 3 GO:0031012 extracellular matrix 2 GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1266738 Developmental Biology 2 R-HSA-1474244 Extracellular matrix organization 1
Partners
FGF2FGF22FGF5HAI-1

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 Purified recombinant FGF-BP (FGFBP1) directly binds FGF-2 without additional cofactors, releases FGF-2 from the extracellular matrix, and stimulates tumor cell and endothelial cell proliferation and chemotaxis in a manner completely blocked by anti-FGF-2 antibodies, demonstrating that its paracrine growth-supporting effects are dependent on endogenously expressed FGF-2. In vitro binding assay with recombinant purified FGF-BP; cell proliferation and chemotaxis assays; antibody neutralization; immunodetection of high-molecular-weight FGF-BP complexes in xenografts International journal of cancer High 11304685
1998 The heparin-binding site of FGFBP1 (HBp17) was mapped to residues 110–143 using protease digestion (V8 and chymotrypsin) followed by heparin-Sepharose isolation of binding fragments; a basic amino acid cluster in this region mediates binding to heparin/heparan sulfate proteoglycan. Protease peptide mapping; heparin-Sepharose affinity chromatography of peptide fragments Biochemistry and molecular biology international Medium 9784842
2001 Serum induction of FGF-BP mRNA in squamous cell carcinoma cells is dependent on PKC, ERK kinase (MEK), and p38 MAP kinase activation, and the C/EBP promoter element is the main element required for this serum response; the mechanism differs from EGF-mediated induction (which uses AP-1 and E-box sites). Promoter analysis; kinase inhibitors; transcription run-on assay; site-directed mutagenesis of promoter elements Oncogene Medium 11313920
2001 HBp17 (FGFBP1) exhibits a biphasic dose-dependent effect on DNA synthesis: low concentrations (8 ng/ml) maximally stimulate DNA synthesis while high concentrations (~500 ng/ml) cause half-maximal inhibition, and this inhibition is reversed by addition of aFGF or bFGF but not EGF. DNA synthesis assay in 3T3 cells and HUVECs at varying HBp17 concentrations; FGF rescue experiment Cell biology international Medium 11407864
2005 Bovine FGF-BP (FGFBP1 ortholog, p37) purified from milk has higher binding affinity for bFGF than lactoferrin, serves as a phosphate acceptor for PKA, CK1, and CK2, and full phosphorylation by PKA abolishes its binding to lactoferrin in vitro; sulfatide-induced conformational changes enable CK1-mediated phosphorylation and also reduce lactoferrin binding. Heparin-HPLC purification; in vitro kinase assays (PKA, CK1, CK2); binding affinity assay; N-terminal sequencing Biochimica et biophysica acta Medium 16412577
2007 N-terminal fragment p5 (residues 24–51) cleaved from FGF-BP in bovine milk is phosphorylated by PKA and CK1δ; CK1δ phosphorylation requires sulfated lipids (sulfatide or cholesterol-3-sulfate); a novel CK1δ phosphorylation site (RNRRGS) and SCS-binding site (RNRR) were identified; p5 (but not phosphorylated p5) directly binds aFGF. Gel filtration purification; in vitro kinase assays; immunoprecipitation; synthetic peptide analysis Biochimica et biophysica acta Medium 17560725
2010 Morpholino-mediated knockdown of Fgfbp1 in zebrafish causes massive cell death prominently in brain and neural tube, indicating that Fgfbp1 is essential for cellular survival during embryogenesis; this function appears to be at least partly FGF2-independent, as fgf2 morphants show a more severe and earlier phenotype. Morpholino knockdown in zebrafish embryos; cell death assay; comparison with fgf2 morphants Molecules and cells Medium 20396962
2012 1α,25(OH)2D3 downregulates HBp17/FGFBP1 mRNA and protein in oral squamous cell carcinoma cells via the NF-κB pathway (upregulating IκBα), and this effect requires vitamin D receptor (VDR); luciferase assay identified the responsive promoter region between −217 and +61. RT-PCR; Western blotting; luciferase reporter assay; VDR siRNA knockdown The Journal of steroid biochemistry and molecular biology Medium 23104116
2014 1α,25(OH)2D3 suppresses HBp17/FGFBP1 expression in both nucleus and cytosol of OSCC cells via NF-κB/VDR pathway, and this suppression results in reduced FGF-2 release into culture medium, establishing FGFBP1 as a chaperone required for FGF-2 secretion. Immunofluorescence; ELISA for FGF-2 in conditioned medium; pharmacological treatment In vitro cellular & developmental biology. Animal Medium 24938357
2016 CREB3L1 suppresses FGFBP1 expression by binding to two CRE-like sites at approximately −1780 and −868 bp in the FGFBP1 promoter; miR-146a targets CREB3L1, thereby de-repressing FGFBP1 expression and increasing FGF2 secretion to promote angiogenesis in HUVECs. Luciferase reporter assay with FGFBP1 promoter; ChIP; CREB3L1 overexpression; FGF2 ELISA; lentiviral miR-146a overexpression Scientific reports Medium 27121396
2017 Muscle fibers secrete and concentrate FGFBP1 at neuromuscular junctions (NMJs); FGFBP1 expression decreases before NMJ degeneration during aging and in SOD1G93A ALS mice; genetic deletion of FGFBP1 causes NMJ structural abnormalities and accelerates NMJ degeneration and death in SOD1G93A mice; TGF-β1 accumulation in stressed muscles inhibits FGFBP1 expression. FGFBP1 knockout mice; SOD1G93A mouse model; NMJ structural analysis; survival assay; TGF-β1 treatment The Journal of neuroscience High 28053031
2017 Inducible transgenic expression of FGFBP1 (BP1) in adult mice causes a sustained >30 mmHg rise in mean arterial blood pressure; this hypertensive effect is prevented by the AngII receptor antagonist candesartan or by the ROS inhibitor tempol; BP1 expression sensitizes peripheral resistance vessels and renal afferent arterioles to AngII constriction by ~20-fold via FGF receptor kinase-dependent signaling; AngII-mediated constriction is abolished in FGF2−/− mice but restored by FGF2 + BP1 add-back; MAPK signaling via MKK4, p38, and JNK integrates FGF receptor and AngII pathway crosstalk. Inducible transgenic mouse model; blood pressure telemetry; pharmacological inhibition (candesartan, tempol, FGFR kinase inhibitor); isolated vessel constriction assay; FGF2−/− mice with protein add-back; proteomics and gene expression analysis of kidney Hypertension High 29158353
2019 FGFBP1 is regulated by the FBW7/c-Myc axis in pancreatic cancer: FBW7 reduces FGFBP1 expression in a c-Myc-dependent manner; FGFBP1 silencing inhibits pancreatic cancer cell proliferation and metastasis, and FBW7 silencing partially reverses the effects of FGFBP1 silencing. siRNA knockdown; overexpression; co-expression correlation in patient tissue; epistasis rescue experiments in cell lines American journal of cancer research Medium 31911852
2020 Endothelial genetic ablation of Fgfbp1 in mice causes transient hypervascularization, delays blood-brain barrier maturation (increased Plvap, increased tracer leakage) due to reduced Wnt/β-catenin activity, and reduces collagen IV deposition in the vascular basement membrane leading to defective pericyte interactions; Fgfbp1 acts cell-autonomously in brain endothelial cells to concentrate Wnt ligands near cell junctions. Endothelial-specific Fgfbp1 knockout mice; tracer leakage assay; immunostaining for Plvap and collagen IV; in vitro barrier assay with Wnt ligand localization Development (Cambridge, England) High 32747434
2020 FGFBP1 mediates AKI-induced brain vascular sensitization to AngII: after bilateral renal ischemia-reperfusion injury, FGF2 and FGFBP1 are upregulated in serum and kidney; exogenous FGF2 + FGFBP1 proteins applied to healthy brain vessels mimic AKI-induced AngII sensitization; Fgfbp1−/− AKI mice fail to develop brain vascular AngII sensitization; FGFR kinase inhibition (BGJ398) reverses sensitization. Bilateral renal ischemia-reperfusion mouse model; Fgfbp1 knockout mice; isolated vessel constriction assay; protein add-back; FGFR inhibitor treatment Hypertension High 33040621
2020 HSD11B2 promotes colorectal cancer cell migration and invasion by upregulating FGFBP1 expression, which subsequently increases AKT phosphorylation; knockdown of either FGFBP1 or AKT impairs the migration/invasion promoted by HSD11B2 overexpression, placing FGFBP1 downstream of HSD11B2 in the HSD11B2-FGFBP1-AKT pathway. mRNA transcriptome array; overexpression and knockdown in CRC cell lines; in vitro migration/invasion assay; in vivo metastasis model; AKT phosphorylation Western blot American journal of cancer research Medium 32195034
2021 In pancreatic cancer, FGFBP1 expressed in cancer-associated fibroblasts (CAFs) promotes FGF22 release; FGF22 activates FGFR2 on pancreatic cancer cells to facilitate their invasion and metastasis; silencing FGFR2 in cancer cells blocks FGF22-driven invasion even with FGF22 treatment. Co-culture of CAFs with pancreatic cancer cells; FGFBP1 knockdown; ELISA for FGF22 in conditioned medium; siRNA knockdown of FGF22 and FGFR2; invasion assay Acta biochimica et biophysica Sinica Medium 34117747
2021 Poly-L-arginine (mimic of eosinophil major basic protein) induces FGFBP1 expression in airway epithelial cells via activation of the mTORC1-STAT3 signaling pathway; STAT3 directly binds to the FGFBP1 promoter and transactivates its expression; FGFBP1 secreted by PLA-treated cells promotes angiogenesis. ChIP for STAT3 on FGFBP1 promoter; mTOR inhibitor (rapamycin); STAT3 pathway assays; angiogenesis assay; OVA asthma mouse model Cell death & disease Medium 34341336
2023 SGCE interacts with the Sp1 transcription factor and translocates to the nucleus, leading to transcriptional activation of FGF-BP1; secreted FGF-BP1 then activates FGF-FGFR signaling to promote breast cancer cell stemness. Co-immunoprecipitation of SGCE and Sp1; nuclear fractionation; SGCE overexpression/depletion; FGF-BP1 promoter reporter assay; stemness functional assays The Journal of biological chemistry Medium 37838174
2023 FGFBP1 acts as an extracellular ligand that rapidly elicits F-actin rearrangement and maintains cobblestone morphology in human keratinocytes; this function depends on HAI-1, as HAI-1 KO cells lose normal morphology and F-actin organization, which is restored by conditioned medium containing FGFBP1 or by recombinant FGFBP1 at ≥1 ng/ml; FGFBP1 was identified as the active factor in conditioned medium by tandem mass spectrometry. HAI-1 knockout in HaCaT cells; conditioned medium rescue; tandem mass spectrometry identification; recombinant FGFBP1 add-back; F-actin imaging Human cell Medium 37076641
2023 KLF5 transcription factor binds to the FGF-BP1 promoter and transcriptionally activates its expression in esophageal squamous cell carcinoma, contributing to tumor proliferation, migration, and invasion via FGF-BP1/SNAIL2 signaling. ChIP for KLF5 on FGFBP1 promoter; luciferase reporter assay; KLF5 overexpression/knockdown; cell proliferation and invasion assays Medical oncology Medium 38087142
2025 FGFBP1 overexpression in sheep adipocytes inhibits proliferation by causing G2/M cell cycle arrest and promotes adipocyte differentiation by upregulating PPARγ, Adiponectin, C/EBPα, and FABP4; knockdown has the opposite effects, establishing FGFBP1 as a regulator of adipogenesis. Overexpression and siRNA knockdown in ovine preadipocytes; cell cycle analysis; lipid droplet staining; RT-qPCR for adipogenic markers Animals Low 40427333
2025 During acute liver injury, FGF6 (induced by glucocorticoid signaling in skeletal muscle) regulates FGFBP1 expression through an ERK-ATF3 signaling pathway and perturbs FGFBP1 heparin-dependent release kinetics by disrupting FGFBP1 liquid-liquid phase separation (LLPS)-driven condensate dynamics at the plasma membrane; circulating FGFBP1 subsequently interacts with hepatic FGF5 via LLPS to regulate liver regeneration. RNA-seq; ATAC-seq; ChIP; luciferase assay; muscle-specific GR knockdown mice; Fgf6 knockout mice; FGF6 neutralizing antibody; LLPS/phase separation assay; ELISA for serum FGFBP1 in ALI patients Military Medical Research Medium 40685360
2025 FGFBP1 promotes TNBC cell proliferation, migration, and invasion by upregulating KLK10 expression, which activates AKT; knockdown of KLK10 or AKT inhibition impairs FGFBP1 overexpression-driven tumor cell phenotypes. FGFBP1 overexpression/knockdown in TNBC cell lines; KLK10 knockdown; AKT inhibitor; proliferation and invasion assays in vitro and in vivo (xenograft) Biochemical and biophysical research communications Low 40233428
2026 Angiotensin II activates STAT3 in cardiomyocytes, which directly induces FGFBP1 transcription; FGFBP1 KO mice show significantly attenuated Ang II- and TAC-induced cardiac hypertrophy, dysfunction, and interstitial fibrosis; pharmacological STAT3 inhibition (S3I-201) reduces FGFBP1 expression and recapitulates the protective KO phenotype. FGFBP1 knockout mice; Ang II infusion and TAC models; RNA sequencing; STAT3 inhibitor (S3I-201); cardiac function and histology Biochimica et biophysica acta. Molecular basis of disease Medium 42013958

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 Sox12, a direct target of FoxQ1, promotes hepatocellular carcinoma metastasis through up-regulating Twist1 and FGFBP1. Hepatology (Baltimore, Md.) 111 25704764
2005 The fibroblast growth factor-binding protein FGF-BP. The international journal of biochemistry & cell biology 78 16324873
2001 An FGF-binding protein (FGF-BP) exerts its biological function by parallel paracrine stimulation of tumor cell and endothelial cell proliferation through FGF-2 release. International journal of cancer 61 11304685
2017 Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS. The Journal of neuroscience : the official journal of the Society for Neuroscience 59 28053031
2020 Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling. Development (Cambridge, England) 38 32747434
2002 Ribozyme-targeting of a secreted FGF-binding protein (FGF-BP) inhibits proliferation of prostate cancer cells in vitro and in vivo. Oncogene 34 12173043
2016 Up-regulation of FGFBP1 signaling contributes to miR-146a-induced angiogenesis in human umbilical vein endothelial cells. Scientific reports 32 27121396
2019 FGFBP1, a downstream target of the FBW7/c-Myc axis, promotes cell proliferation and migration in pancreatic cancer. American journal of cancer research 29 31911852
2011 Pathway analysis shows association between FGFBP1 and hypertension. Journal of the American Society of Nephrology : JASN 28 21436287
2011 Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma. Molecular cancer 28 22111880
2021 Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway. Cell death & disease 27 34341336
2017 Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein). Hypertension (Dallas, Tex. : 1979) 23 29158353
2001 Serum induction of the fibroblast growth factor-binding protein (FGF-BP) is mediated through ERK and p38 MAP kinase activation and C/EBP-regulated transcription. Oncogene 23 11313920
2012 1α,25OH2D3 down-regulates HBp17/FGFBP-1 expression via NF-κB pathway. The Journal of steroid biochemistry and molecular biology 20 23104116
2007 Immunohistochemical expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) as an angiogenic factor in head and neck tumorigenesis. Oncology reports 20 17273738
2000 Tissue distribution and retinoid-mediated downregulation of an FGF-binding protein (FGF-BP) in the rat. Growth factors (Chur, Switzerland) 20 10831072
2020 Eldecalcitol (ED-71)-induced exosomal miR-6887-5p suppresses squamous cell carcinoma cell growth by targeting heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1). In vitro cellular & developmental biology. Animal 19 32185608
2014 1α,25(OH)₂D₃ inhibits FGF-2 release from oral squamous cell carcinoma cells through down-regulation of HBp17/FGFBP-1. In vitro cellular & developmental biology. Animal 18 24938357
2013 A comparative study of clinicopathological significance, FGFBP1, and WISP-2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder. International journal of clinical oncology 18 23592278
2021 FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer. Acta biochimica et biophysica Sinica 17 34117747
2020 Type-2 11β-hydroxysteroid dehydrogenase promotes the metastasis of colorectal cancer via the Fgfbp1-AKT pathway. American journal of cancer research 16 32195034
2020 Acute Kidney Injury Sensitizes the Brain Vasculature to Ang II (Angiotensin II) Constriction via FGFBP1 (Fibroblast Growth Factor Binding Protein 1). Hypertension (Dallas, Tex. : 1979) 14 33040621
2005 Purification and biochemical characterization of a fibroblast growth factor-binding protein (FGF-BP) from the lactoferrin fraction of bovine milk. Biochimica et biophysica acta 14 16412577
2022 FGFBP1 as a potential biomarker predicting bacillus Calmette-Guérin response in bladder cancer. Frontiers in immunology 13 36119059
2018 Ghrelin Ameliorates Traumatic Brain Injury by Down-Regulating bFGF and FGF-BP. Frontiers in neuroscience 13 30026681
2017 Eldecalcitol (ED-71), an analog of 1α,25(OH)2D3, inhibits the growth of squamous cell carcinoma (SCC) cells in vitro and in vivo by down-regulating expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) and FGF-2. In vitro cellular & developmental biology. Animal 12 28710602
2014 Expression of a Secreted Fibroblast Growth Factor Binding Protein-1 (FGFBP1) in Angioproliferative Kaposi Sarcoma. Journal of AIDS & clinical research 11 25429350
2023 SGCE promotes breast cancer stemness by promoting the transcription of FGF-BP1 by Sp1. The Journal of biological chemistry 10 37838174
2010 Fgfbp1 is essential for the cellular survival during zebrafish embryogenesis. Molecules and cells 10 20396962
1998 Purification of heparin-binding protein HBp17 and identification of HBp17 heparin binding site. Biochemistry and molecular biology international 10 9784842
2023 miR-4432 Targets FGFBP1 in Human Endothelial Cells. Biology 9 36979151
2013 Polymorphisms in FGFBP1 and FGFBP2 genes associated with carcass and meat quality traits in chickens. Genetics and molecular research : GMR 9 23408407
2023 KLF5 promotes esophageal squamous cell cancer through the transcriptional activation of FGFBP1. Medical oncology (Northwood, London, England) 7 38087142
2021 DNA polymorphisms of FGFBP1, leptin, κ-casein, and αs1-casein genes and their association with reproductive performance in dromedary she-camels. Theriogenology 7 34749032
2018 Temporal and spatial expression of fgfbp genes in zebrafish. Gene 6 29551495
2001 Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells. Cell biology international 5 11407864
2025 Decoding the Function of FGFBP1 in Sheep Adipocyte Proliferation and Differentiation. Animals : an open access journal from MDPI 4 40427333
2025 Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis. Military Medical Research 4 40685360
2007 Biochemical characterization of a N-terminal fragment (p5) cleaved from fibroblast growth factor-binding protein (FGF-BP) in bovine milk in vitro. Biochimica et biophysica acta 3 17560725
2025 Molecular structure of Fgfbp1 protein and its regulation of zebrafish cartilage development and homeostasis: Implications for Wnt signaling and ECM stability. International journal of biological macromolecules 2 40120897
2023 HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes. Human cell 2 37076641
2026 HMGA1 Activates FGFBP1 Transcription to Enhance Angiogenesis Induction and Tumor Progression via FGF2/FGFR1 Pathway. International journal of biological sciences 1 41943828
2025 FGFBP1 promotes triple-negative breast cancer progression through the KLK10-AKT axis. Biochemical and biophysical research communications 1 40233428
2026 Cardiomyocytes FGFBP1 induction by STAT3 drives pathological cardiac remodeling. Biochimica et biophysica acta. Molecular basis of disease 0 42013958
2003 [Effect of FGF-BP on angiogenesis in squamous cell carcinoma]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 0 12910691

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