Affinage

FGFBP1

Fibroblast growth factor-binding protein 1 · UniProt Q14512

Length
234 aa
Mass
26.3 kDa
Annotated
2026-04-28
45 papers in source corpus 23 papers cited in narrative 23 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FGFBP1 is a secreted extracellular chaperone that mobilizes FGF ligands from heparan sulfate proteoglycan stores in the extracellular matrix, thereby amplifying paracrine FGF–FGFR signaling in contexts ranging from angiogenesis and vascular tone regulation to neuromuscular junction maintenance, blood–brain barrier maturation, and pathological cardiac remodeling. The protein directly binds FGF-2 through a heparin-binding domain (residues 110–143) and releases it from the ECM; its proliferative and chemotactic effects are abolished by anti-FGF-2 neutralization, establishing functional dependence on FGF ligand availability (PMID:11304685, PMID:9784842). Beyond canonical FGF-2 mobilization, FGFBP1 sensitizes resistance arterioles to angiotensin II constriction via FGFR–MAPK crosstalk, raising systemic blood pressure in transgenic mice (PMID:29158353); in brain endothelium it cell-autonomously concentrates Wnt ligands to promote β-catenin activity and basement membrane collagen IV deposition during blood–brain barrier maturation (PMID:32747434); and it is a STAT3-dependent effector of AngII-induced cardiac hypertrophy and fibrosis (PMID:42013958). FGFBP1 transcription is governed by a convergent set of transcription factors—including STAT3, C/EBP, Sox12, HMGA1, Sp1/SGCE, and CREB3L1—and is modulated by mTORC1, NF-κB, and vitamin D receptor signaling (PMID:34341336, PMID:11313920, PMID:25704764, PMID:41943828).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1998 Medium

    Mapping the heparin-binding domain to residues 110–143 established the structural basis for FGFBP1's interaction with heparan sulfate proteoglycans and, by extension, its capacity to contact ECM-sequestered FGFs.

    Evidence Protease digestion of purified HBp17 followed by heparin-Sepharose affinity isolation of fragments

    PMID:9784842

    Open questions at the time
    • Single peptide-mapping study; site-directed mutagenesis of individual basic residues not performed
    • Three-dimensional structure of the heparin-binding domain is unresolved
    • Affinity constants for heparan sulfate versus heparin not determined
  2. 2001 High

    Reconstitution with purified proteins demonstrated that FGFBP1 directly binds FGF-2, liberates it from ECM, and drives proliferation/chemotaxis in an FGF-2-dependent manner, establishing its core molecular function as an FGF mobilizer.

    Evidence In vitro binding assay with recombinant proteins, proliferation/chemotaxis assays, anti-FGF-2 antibody neutralization

    PMID:11304685 PMID:11407864

    Open questions at the time
    • Whether FGFBP1 mobilizes FGF family members beyond FGF-1 and FGF-2 was not systematically tested
    • Stoichiometry of the FGFBP1–FGF-2 complex undetermined
  3. 2001 Medium

    Identification of C/EBP-dependent transcription downstream of PKC–MEK/ERK–p38 signaling provided the first map of upstream signals controlling FGFBP1 expression, distinguishing serum- from EGF-driven induction.

    Evidence Promoter deletion/luciferase analysis with kinase inhibitors in ME-180 cells

    PMID:11313920

    Open questions at the time
    • C/EBP isoform specificity not resolved
    • In vivo relevance of these promoter elements not tested
  4. 2010 Medium

    Morpholino knockdown in zebrafish revealed an essential developmental role for fgfbp1 in neural cell survival that can operate independently of FGF2, broadening the functional scope beyond FGF-2 mobilization.

    Evidence Morpholino antisense knockdown in zebrafish embryos with phenotypic scoring

    PMID:20396962

    Open questions at the time
    • Morpholino off-target effects not fully excluded
    • The FGF2-independent mechanism was not molecularly identified
    • Mammalian developmental loss-of-function data were not yet available
  5. 2012 Medium

    Vitamin D/VDR-mediated repression of FGFBP1 through NF-κB inhibition established a hormonal input that links metabolic status to FGF mobilization and provided a pharmacological lever for FGFBP1 downregulation.

    Evidence Luciferase promoter assay, IκBα Western blot, VDR siRNA in OSCC cells; confirmed by immunofluorescence and FGF-2 ELISA

    PMID:23104116 PMID:24938357

    Open questions at the time
    • Direct NF-κB subunit binding to the FGFBP1 promoter not shown by ChIP
    • In vivo relevance of VDR-mediated FGFBP1 repression untested
  6. 2015 Medium

    ChIP and mutagenesis confirmed Sox12 as a direct transcriptional activator of FGFBP1, with functional epistasis showing FGFBP1 mediates Sox12-driven HCC metastasis, expanding the roster of upstream regulators.

    Evidence Serial promoter deletion, site-directed mutagenesis, ChIP, siRNA rescue, in vivo metastasis assay

    PMID:25704764

    Open questions at the time
    • Sox12-FGFBP1 axis validated only in hepatocellular carcinoma context
    • Whether Sox12 cooperates with C/EBP or STAT3 at the promoter is unknown
  7. 2016 Medium

    Discovery that CREB3L1 directly represses FGFBP1 and is itself silenced by miR-146a introduced a microRNA–transcription factor relay controlling FGFBP1-dependent angiogenesis.

    Evidence ChIP of CREB3L1 on FGFBP1 promoter CRE-like sites, lentiviral miR-146a overexpression, FGF2 ELISA in endothelial cells

    PMID:27121396

    Open questions at the time
    • Endothelial-specific in vivo validation lacking
    • Whether other CRE-binding repressors compensate when CREB3L1 is depleted is unknown
  8. 2017 High

    Genetic loss-of-function in mice demonstrated two distinct physiological roles: FGFBP1 is required for neuromuscular junction integrity (declining with age and in ALS), and its transgenic overexpression raises blood pressure by sensitizing resistance vessels to angiotensin II through FGFR–MAPK crosstalk.

    Evidence FGFBP1 KO and inducible transgenic mice; SOD1G93A double mutants; isolated arteriole constriction with pharmacological dissection and FGF2 KO rescue

    PMID:28053031 PMID:29158353

    Open questions at the time
    • Molecular intermediates linking FGFR activation to AngII receptor sensitization at the single-cell level not defined
    • TGF-β1-mediated suppression of FGFBP1 at the NMJ lacks promoter-level mechanism
  9. 2020 High

    Endothelial-specific KO showed FGFBP1 cell-autonomously concentrates Wnt ligands to drive β-catenin activity and collagen IV deposition during blood–brain barrier maturation, revealing a function beyond classical FGF mobilization.

    Evidence Conditional endothelial KO mouse, tracer leakage, Plvap upregulation, Wnt reporter in brain endothelial cells

    PMID:32747434

    Open questions at the time
    • How FGFBP1 physically concentrates Wnt ligands is unresolved
    • Whether this Wnt-related role is independent of FGF binding was not fully dissected
  10. 2020 High

    Multiple studies positioned FGFBP1 as a conduit linking upstream oncogenic signals (HSD11B2, AKT) and vascular stress (AKI) to FGF-dependent pathological responses, reinforcing its role as a signaling amplifier across organ systems.

    Evidence AKI model in FGFBP1 KO mice with protein add-back; HSD11B2-FGFBP1-AKT epistasis in CRC cells

    PMID:32195034 PMID:33040621

    Open questions at the time
    • AKI-to-FGFBP1 induction mechanism in kidney not identified
    • Direct physical interaction between FGFBP1 and AKT pathway components not demonstrated
  11. 2021 Medium

    ChIP validated STAT3 as a direct activator of the FGFBP1 promoter downstream of mTORC1, linking eosinophilic inflammation to FGFBP1-dependent angiogenesis in asthma; separately, FGFBP1 was shown to regulate paracrine FGF22–FGFR2 signaling between CAFs and pancreatic cancer cells.

    Evidence ChIP of STAT3 on FGFBP1 promoter, rapamycin in OVA asthma model; CAF-cancer cell co-culture with FGFBP1/FGF22/FGFR2 knockdown

    PMID:34117747 PMID:34341336

    Open questions at the time
    • Whether STAT3 and C/EBP co-occupy the promoter simultaneously is unknown
    • FGF22 mobilization by FGFBP1 not confirmed with purified protein binding assays
  12. 2023 Medium

    An FGF-independent function was uncovered: FGFBP1 regulates F-actin organization and cobblestone morphology in keratinocytes through a HAI-1-dependent mechanism, demonstrating activities beyond FGF chaperoning.

    Evidence HAI-1 KO HaCaT cells rescued by 1 ng/ml recombinant FGFBP1; mass spectrometry identification; F-actin staining

    PMID:37076641

    Open questions at the time
    • The receptor or membrane partner mediating this FGF-independent actin effect is unidentified
    • HAI-1 dependence mechanism (protease inhibition vs. direct interaction) not dissected
  13. 2025 Medium

    Discovery that FGF6–ERK–ATF3 signaling from muscle regulates FGFBP1 expression, and that FGFBP1 undergoes liquid–liquid phase separation modulated by FGF6 to control its release and subsequent interaction with hepatic FGF5 for liver regeneration, introduced phase separation as a biophysical mechanism governing FGFBP1 function.

    Evidence RNA-seq, ATAC-seq, ChIP, muscle-specific KO mice, FGF6 neutralizing antibody, in vitro phase separation assay

    PMID:40685360

    Open questions at the time
    • LLPS-driven condensate formation observed in vitro; in vivo condensate visualization not shown
    • Structural determinants of FGFBP1 phase separation are unknown
    • Physiological relevance of FGFBP1–FGF5 interaction for liver regeneration requires independent replication
  14. 2026 High

    FGFBP1 was established as a STAT3-dependent effector of pathological cardiac remodeling: its genetic ablation attenuated AngII- and TAC-induced hypertrophy and fibrosis, closing a loop from AngII→STAT3→FGFBP1→profibrotic signaling.

    Evidence FGFBP1 KO mice subjected to AngII infusion and TAC, RNA-seq, STAT3 inhibitor S3I-201

    PMID:42013958

    Open questions at the time
    • Downstream effectors of FGFBP1 in cardiomyocytes (which FGF ligands are mobilized) not identified
    • Whether cardiac FGFBP1 also sensitizes coronary vasculature to AngII is untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis for FGFBP1's selectivity among FGF family members, the molecular mechanism of its FGF-independent functions (Wnt concentration, actin remodeling), and whether its liquid–liquid phase separation behavior operates in vivo to regulate ligand release.
  • No crystal or cryo-EM structure of FGFBP1 alone or in complex with any ligand
  • FGF-independent mechanisms lack identified receptors or binding partners
  • Phase separation as a regulatory mechanism requires in vivo validation

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008289 lipid binding 3 GO:0044183 protein folding chaperone 3 GO:0048018 receptor ligand activity 3 GO:0098772 molecular function regulator activity 3
Localization
GO:0005576 extracellular region 5 GO:0031012 extracellular matrix 2 GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-1643685 Disease 4 R-HSA-1266738 Developmental Biology 2 R-HSA-1474244 Extracellular matrix organization 1
Partners
FGF1FGF2FGF22FGF5FGFR1FGFR2HAI-1STAT3

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 Purified recombinant FGFBP1 directly binds FGF-2 without additional cofactors, releases FGF-2 from the extracellular matrix, and stimulates tumor cell and endothelial cell proliferation/chemotaxis in a manner fully blocked by anti-FGF-2 antibodies, demonstrating that its paracrine growth-supporting effect is dependent on endogenously expressed FGF-2. In vitro binding assay with recombinant purified FGF-BP, cell proliferation and chemotaxis assays, antibody neutralization, immunoreactive complex analysis International journal of cancer High 11304685
1998 Peptide mapping of FGFBP1 (HBp17) identified residues 110–143 as the principal heparin-binding site, with a basic amino acid cluster contributing to binding to heparin and heparan sulfate proteoglycans of the ECM. V8 protease and chymotrypsin digestion of purified HBp17 followed by heparin-Sepharose affinity isolation of binding fragments Biochemistry and molecular biology international Medium 9784842
2001 Serum induction of FGF-BP transcription requires PKC, MEK/ERK, and p38 MAP kinase activation, and is mediated through C/EBP promoter elements rather than AP-1 or E-box sites, as distinct from EGF-mediated induction. Promoter deletion analysis, kinase inhibitors, transcription rate assay, serum stimulation of ME-180 cells Oncogene Medium 11313920
2005 Bovine milk FGFBP1 (p37) binds bFGF with higher affinity than lactoferrin, serves as a phosphate acceptor for PKA, CK1, and CK2, and full PKA-mediated phosphorylation abolishes its binding to lactoferrin; sulfatide-induced conformational changes enable CK1 phosphorylation and also reduce lactoferrin binding. HPLC purification, in vitro kinase assay, FGF binding assay, phosphorylation/binding competition experiments Biochimica et biophysica acta Medium 16412577
2001 FGFBP1 (HBp17) exerts a biphasic dose-dependent effect on DNA synthesis: stimulatory at low concentrations (~8 ng/ml) and inhibitory at high concentrations (~500 ng/ml); the inhibitory effect is reversed by addition of aFGF or bFGF but not EGF, indicating functional interdependence with FGFs. DNA synthesis assay in 3T3 cells and HUVECs with recombinant HBp17, FGF rescue experiments Cell biology international Medium 11407864
2012 1α,25(OH)2D3 down-regulates FGFBP1 (HBp17) expression via the NF-κB pathway: treatment upregulates IκBα, and promoter luciferase assays map the responsive region to -217/+61; VDR siRNA silencing abrogates the effect, confirming VDR dependence. Luciferase reporter assay, NF-κB pathway analysis (IκBα Western blot), VDR siRNA knockdown The Journal of steroid biochemistry and molecular biology Medium 23104116
2014 1α,25(OH)2D3 suppresses FGFBP1 expression in both nucleus and cytosol of OSCC cells, leading to reduced FGF-2 release into conditioned medium, directly linking FGFBP1 levels to extracellular FGF-2 availability. Immunofluorescence localization, ELISA measurement of FGF-2 in conditioned medium, 1α,25(OH)2D3 treatment In vitro cellular & developmental biology. Animal Medium 24938357
2016 miR-146a promotes angiogenesis in endothelial cells via the CREB3L1-FGFBP1 axis: miR-146a directly targets CREB3L1, which normally represses FGFBP1 transcription by binding two CRE-like sites at −1780 and −868 bp relative to the FGFBP1 TSS; loss of CREB3L1 increases FGFBP1 expression and FGF2 secretion. Luciferase reporter assay, ChIP of CREB3L1 on FGFBP1 promoter, lentiviral miR-146a overexpression, FGF2 ELISA Scientific reports Medium 27121396
2017 Muscle fiber-secreted FGFBP1 is concentrated at neuromuscular junctions (NMJs); its expression decreases during aging and in SOD1G93A ALS mice before NMJ degeneration. FGFBP1 knockout mice develop structural NMJ abnormalities; knockout in SOD1G93A mice accelerates NMJ degeneration and death. TGF-β1 accumulation in skeletal muscle inhibits FGFBP1 expression. FGFBP1 knockout mouse model, SOD1G93A double mutant, immunofluorescence localization at NMJs, TGF-β1 treatment The Journal of neuroscience High 28053031
2017 Inducible transgenic expression of FGFBP1 in adult mice elevates mean arterial pressure by >30 mmHg. This hypertensive effect is prevented by angiotensin II receptor antagonist candesartan or ROS inhibitor tempol. FGFBP1 sensitizes peripheral resistance vessels and renal afferent arterioles to AngII constriction ~20-fold via FGF receptor kinase-dependent signaling. In FGF2−/− mice, AngII-mediated arteriolar constriction is abolished but restored by FGF2 plus FGFBP1 add-back. Proteomics identifies downstream MAPK signaling via MKK4, p38, and JNK as integrators of FGFR and AngII crosstalk. Inducible transgenic mouse model, pharmacological inhibition (candesartan, tempol, FGFR kinase inhibitor), isolated arteriole constriction assay, FGF2−/− mice with protein add-back, kidney proteomics/gene expression Hypertension High 29158353
2020 Endothelial-specific ablation of Fgfbp1 in mice delays BBB maturation with upregulation of Plvap and increased tracer leakage, reduces Wnt/β-catenin activity, and decreases collagen IV deposition in the vascular basement membrane, impairing endothelial cell-pericyte interactions. Fgfbp1 acts cell-autonomously in brain endothelial cells to concentrate Wnt ligands near cell junctions. Conditional endothelial knockout mouse, tracer leakage assay, immunofluorescence, collagen IV staining, in vitro Wnt reporter in mBECs Development High 32747434
2020 FGFBP1-mediated signaling sensitizes brain microvessels and macrovessels to AngII constriction after acute kidney injury (AKI); administration of recombinant FGF2 plus FGFBP1 proteins to healthy isolated brain vessels mimics AKI-induced sensitization, and Fgfbp1−/− AKI mice fail to develop this sensitization. FGFR kinase inhibition with BGJ398 reverses the effect. Bilateral renal ischemia-reperfusion AKI model, Fgfbp1−/− mice, ex vivo vessel constriction assay, recombinant protein add-back, pharmacological FGFR inhibition Hypertension High 33040621
2020 HSD11B2 promotes colorectal cancer cell migration and invasion by upregulating FGFBP1 expression, which subsequently increases AKT phosphorylation. Knockdown of FGFBP1 or AKT impairs the pro-invasive effect of HSD11B2 overexpression, placing FGFBP1 downstream of HSD11B2 in the HSD11B2-FGFBP1-AKT axis. mRNA transcriptome array, overexpression and knockdown in CRC cells, in vitro migration/invasion assays, in vivo xenograft, AKT phosphorylation Western blot American journal of cancer research Medium 32195034
2021 FGFBP1 promotes pancreatic cancer invasion/metastasis through a paracrine mechanism involving cancer-associated fibroblasts (CAFs): FGFBP1 regulates FGF22 secretion from CAFs, and FGF22 signals through FGFR2 on pancreatic cancer cells to facilitate their migration and invasion. Co-culture of CAFs and pancreatic cancer cells with FGFBP1/FGF22/FGFR2 knockdown, ELISA for FGF22 in conditioned medium, invasion assay Acta biochimica et biophysica Sinica Medium 34117747
2021 Poly-L-arginine (mimic of eosinophil MBP) induces FGFBP1 expression in airway epithelial cells via the mTORC1-STAT3 pathway; STAT3 directly binds the FGFBP1 promoter to transactivate it; secreted FGFBP1 acts as a proangiogenic factor, and rapamycin treatment reduces FGFBP1 expression and angiogenesis in OVA-induced asthma mice. ChIP of STAT3 on FGFBP1 promoter, mTORC1/STAT3 inhibitors, OVA mouse model, rapamycin treatment Cell death & disease Medium 34341336
2015 FGFBP1 is a direct transcriptional target of Sox12: serial deletion, site-directed mutagenesis, and ChIP assays confirm Sox12 binding to the FGFBP1 promoter. FGFBP1 knockdown decreases Sox12-mediated HCC invasion and metastasis, whereas FGFBP1 overexpression rescues the reduced metastasis caused by Sox12 knockdown. Serial deletion and mutagenesis of FGFBP1 promoter, ChIP, siRNA knockdown and rescue overexpression, in vitro invasion and in vivo metastasis assays Hepatology Medium 25704764
2023 SGCE interacts with the Sp1 transcription factor and translocates to the nucleus, increasing FGF-BP1 transcription; secreted FGF-BP1 then activates FGF-FGFR signaling to promote cancer cell stemness in triple-negative breast cancer. Co-immunoprecipitation of SGCE-Sp1, nuclear fractionation, transcriptional reporter assay, FGFBP1 knockdown/overexpression, stem cell assays The Journal of biological chemistry Medium 37838174
2023 FGFBP1 acts as an extracellular ligand that rapidly elicits F-actin rearrangement and maintains cobblestone morphology of human keratinocytes independently of FGF interactions. This novel function requires HAI-1; recombinant FGFBP1 at 1 ng/ml reverts morphological and F-actin defects caused by HAI-1 knockout. HAI-1 KO HaCaT cells, conditioned medium rescue, tandem mass spectrometry identification of FGFBP1, recombinant FGFBP1 add-back, F-actin staining Human cell Medium 37076641
2010 Morpholino knockdown of fgfbp1 in zebrafish embryos causes massive cell death predominantly in the brain and neural tube and structural abnormalities, indicating an essential role in cellular survival during embryogenesis that can be exerted in an FGF2-independent manner. Morpholino antisense knockdown in zebrafish, phenotypic analysis of cell death and structural defects Molecules and cells Medium 20396962
2025 FGF6 from skeletal muscle regulates FGFBP1 expression through ERK-ATF3 signaling, and FGF6 also perturbs heparin-dependent release kinetics of FGFBP1 by disrupting its liquid-liquid phase separation (LLPS)-driven condensates at the plasma membrane. Circulating FGFBP1 then interacts with hepatic FGF5 via LLPS mechanisms to regulate liver regeneration. RNA-seq, ATAC-seq, ChIP, luciferase assay, muscle-specific GR/FGF6 knockout mice, FGF6 neutralizing antibody, phase separation assay, ELISA Military Medical Research Medium 40685360
2026 FGFBP1 is a STAT3-dependent effector of pathological cardiac remodeling: AngII activates STAT3 in cardiomyocytes, which induces FGFBP1 transcription and promotes profibrotic signaling. FGFBP1 KO mice show significantly attenuated cardiac hypertrophy and fibrosis after AngII/TAC, and STAT3 inhibitor S3I-201 reduces FGFBP1 expression and recapitulates the KO phenotype. FGFBP1 KO mouse model, AngII and TAC cardiac stress models, RNA sequencing, STAT3 pharmacological inhibition, cardiac function and fibrosis assessment Biochimica et biophysica acta. Molecular basis of disease High 42013958
2026 HMGA1 directly binds the FGFBP1 promoter to induce its expression, increasing secretion of FGF2 and promoting tumor progression and angiogenesis in head and neck squamous cell carcinoma via FGFR1 signaling. FGFBP1 silencing or FGFR1 inhibitor PD166866 recapitulates HMGA1 silencing phenotypes. ChIP of HMGA1 on FGFBP1 promoter, RNA sequencing, FGFBP1 siRNA, FGFR1 inhibitor, xenograft mouse model International journal of biological sciences Medium 41943828
2025 FGFBP1 promotes TNBC cell proliferation, migration, and invasion through the KLK10-AKT axis: FGFBP1 overexpression upregulates KLK10 expression, activating AKT; KLK10 knockdown or AKT inhibition impairs the pro-tumorigenic effects of FGFBP1 overexpression. Overexpression and knockdown in TNBC cell lines, in vivo xenograft, Western blot for KLK10/AKT, rescue epistasis experiments Biochemical and biophysical research communications Medium 40233428

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 Sox12, a direct target of FoxQ1, promotes hepatocellular carcinoma metastasis through up-regulating Twist1 and FGFBP1. Hepatology (Baltimore, Md.) 110 25704764
2005 The fibroblast growth factor-binding protein FGF-BP. The international journal of biochemistry & cell biology 77 16324873
2001 An FGF-binding protein (FGF-BP) exerts its biological function by parallel paracrine stimulation of tumor cell and endothelial cell proliferation through FGF-2 release. International journal of cancer 61 11304685
2017 Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS. The Journal of neuroscience : the official journal of the Society for Neuroscience 58 28053031
2020 Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling. Development (Cambridge, England) 36 32747434
2002 Ribozyme-targeting of a secreted FGF-binding protein (FGF-BP) inhibits proliferation of prostate cancer cells in vitro and in vivo. Oncogene 34 12173043
2016 Up-regulation of FGFBP1 signaling contributes to miR-146a-induced angiogenesis in human umbilical vein endothelial cells. Scientific reports 31 27121396
2019 FGFBP1, a downstream target of the FBW7/c-Myc axis, promotes cell proliferation and migration in pancreatic cancer. American journal of cancer research 29 31911852
2011 Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma. Molecular cancer 28 22111880
2021 Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway. Cell death & disease 26 34341336
2011 Pathway analysis shows association between FGFBP1 and hypertension. Journal of the American Society of Nephrology : JASN 26 21436287
2001 Serum induction of the fibroblast growth factor-binding protein (FGF-BP) is mediated through ERK and p38 MAP kinase activation and C/EBP-regulated transcription. Oncogene 23 11313920
2017 Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein). Hypertension (Dallas, Tex. : 1979) 21 29158353
2012 1α,25OH2D3 down-regulates HBp17/FGFBP-1 expression via NF-κB pathway. The Journal of steroid biochemistry and molecular biology 20 23104116
2007 Immunohistochemical expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) as an angiogenic factor in head and neck tumorigenesis. Oncology reports 20 17273738
2000 Tissue distribution and retinoid-mediated downregulation of an FGF-binding protein (FGF-BP) in the rat. Growth factors (Chur, Switzerland) 20 10831072
2020 Eldecalcitol (ED-71)-induced exosomal miR-6887-5p suppresses squamous cell carcinoma cell growth by targeting heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1). In vitro cellular & developmental biology. Animal 19 32185608
2014 1α,25(OH)₂D₃ inhibits FGF-2 release from oral squamous cell carcinoma cells through down-regulation of HBp17/FGFBP-1. In vitro cellular & developmental biology. Animal 18 24938357
2013 A comparative study of clinicopathological significance, FGFBP1, and WISP-2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder. International journal of clinical oncology 18 23592278
2021 FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer. Acta biochimica et biophysica Sinica 17 34117747
2020 Type-2 11β-hydroxysteroid dehydrogenase promotes the metastasis of colorectal cancer via the Fgfbp1-AKT pathway. American journal of cancer research 16 32195034
2005 Purification and biochemical characterization of a fibroblast growth factor-binding protein (FGF-BP) from the lactoferrin fraction of bovine milk. Biochimica et biophysica acta 14 16412577
2018 Ghrelin Ameliorates Traumatic Brain Injury by Down-Regulating bFGF and FGF-BP. Frontiers in neuroscience 13 30026681
2022 FGFBP1 as a potential biomarker predicting bacillus Calmette-Guérin response in bladder cancer. Frontiers in immunology 12 36119059
2020 Acute Kidney Injury Sensitizes the Brain Vasculature to Ang II (Angiotensin II) Constriction via FGFBP1 (Fibroblast Growth Factor Binding Protein 1). Hypertension (Dallas, Tex. : 1979) 12 33040621
2017 Eldecalcitol (ED-71), an analog of 1α,25(OH)2D3, inhibits the growth of squamous cell carcinoma (SCC) cells in vitro and in vivo by down-regulating expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) and FGF-2. In vitro cellular & developmental biology. Animal 12 28710602
2023 SGCE promotes breast cancer stemness by promoting the transcription of FGF-BP1 by Sp1. The Journal of biological chemistry 10 37838174
2014 Expression of a Secreted Fibroblast Growth Factor Binding Protein-1 (FGFBP1) in Angioproliferative Kaposi Sarcoma. Journal of AIDS & clinical research 10 25429350
2010 Fgfbp1 is essential for the cellular survival during zebrafish embryogenesis. Molecules and cells 10 20396962
1998 Purification of heparin-binding protein HBp17 and identification of HBp17 heparin binding site. Biochemistry and molecular biology international 10 9784842
2013 Polymorphisms in FGFBP1 and FGFBP2 genes associated with carcass and meat quality traits in chickens. Genetics and molecular research : GMR 9 23408407
2023 miR-4432 Targets FGFBP1 in Human Endothelial Cells. Biology 8 36979151
2021 DNA polymorphisms of FGFBP1, leptin, κ-casein, and αs1-casein genes and their association with reproductive performance in dromedary she-camels. Theriogenology 7 34749032
2023 KLF5 promotes esophageal squamous cell cancer through the transcriptional activation of FGFBP1. Medical oncology (Northwood, London, England) 6 38087142
2018 Temporal and spatial expression of fgfbp genes in zebrafish. Gene 6 29551495
2001 Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells. Cell biology international 5 11407864
2025 Decoding the Function of FGFBP1 in Sheep Adipocyte Proliferation and Differentiation. Animals : an open access journal from MDPI 3 40427333
2025 Glucocorticoids trigger muscle-liver crosstalk to attenuate acute liver injury and promote liver regeneration via the FGF6-FGFBP1 axis. Military Medical Research 3 40685360
2007 Biochemical characterization of a N-terminal fragment (p5) cleaved from fibroblast growth factor-binding protein (FGF-BP) in bovine milk in vitro. Biochimica et biophysica acta 3 17560725
2025 Molecular structure of Fgfbp1 protein and its regulation of zebrafish cartilage development and homeostasis: Implications for Wnt signaling and ECM stability. International journal of biological macromolecules 2 40120897
2023 HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes. Human cell 2 37076641
2025 FGFBP1 promotes triple-negative breast cancer progression through the KLK10-AKT axis. Biochemical and biophysical research communications 1 40233428
2026 HMGA1 Activates FGFBP1 Transcription to Enhance Angiogenesis Induction and Tumor Progression via FGF2/FGFR1 Pathway. International journal of biological sciences 0 41943828
2026 Cardiomyocytes FGFBP1 induction by STAT3 drives pathological cardiac remodeling. Biochimica et biophysica acta. Molecular basis of disease 0 42013958
2003 [Effect of FGF-BP on angiogenesis in squamous cell carcinoma]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 0 12910691