Affinage

EXOSC8

Exosome complex component RRP43 · UniProt Q96B26

Length
276 aa
Mass
30.0 kDa
Annotated
2026-06-09
55 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/7 claims corpus-supported (86%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

EXOSC8 (yeast Rrp43p) is an essential structural core subunit of the conserved RNA exosome, a 3'→5' exoribonuclease complex that processes and degrades diverse RNA substrates (PMID:9390555). Its RNase PH fold mediates both core architecture and sequence-specific RNA recognition: the RNase PH domain binds AU-rich element (ARE)-containing RNAs with preference for U-/AU-rich sequences (PMID:16912217), and EXOSC8 itself exhibits phosphorolytic 3'→5' exoribonuclease activity that trims precursor tRNA 3' termini in vitro (PMID:11929972). Within the exosome core, EXOSC8 is a principal docking site for the catalytic subunit Rrp44/Dis3, which anchors to the complex through Rrp45 and Rrp43 interfaces (PMID:17942686), and mutations in EXOSC8 destabilize the nine-subunit complex while paradoxically increasing exonuclease activity (PMID:24237138). Functionally, EXOSC8 is required for maturation of 5.8S, 18S, and 25S rRNA and for the degradation of poly(A)+ rRNA intermediates, with a substrate specificity distinct from Rrp6 (PMID:9390555, PMID:9973615, PMID:18940861); it localizes predominantly to the nucleus and concentrates in the granular component of the nucleolus alongside the rRNA-processing cofactor Mtr4, consistent with a role in early pre-rRNA processing (PMID:32554806, PMID:40266794). Loss of EXOSC8 couples defective ribosome biogenesis to surveillance signaling: knockdown triggers release of RPL5/RPL11 from the nucleolus, which sequester Mdm2 to stabilize and activate p53, producing G2/M arrest and apoptosis (PMID:32527837, PMID:36348012). Homozygous missense mutations in EXOSC8 cause progressive human neurological disease, mechanistically attributed to failed degradation of ARE-containing myelin protein mRNAs (e.g., MBP, PLP) and disrupted myelination (PMID:24989451). EXOSC8 additionally acts as an endogenous suppressor of erythroid differentiation, repressed by GATA-1/Foxo3, such that its downregulation drives erythroid maturation (PMID:25115889).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 1997 High

    Established EXOSC8's founding identity: that the protein is an essential, RNase PH-homologous subunit of a conserved 3'→5' exoribonuclease complex, defining the exosome as a discrete machine.

    Evidence Biochemical co-purification, mass spectrometry, in vitro exoribonuclease assays and depletion genetics in yeast

    PMID:9390555

    Open questions at the time
    • Did not resolve which substrates EXOSC8 itself acts on versus the complex
    • No structural placement of the subunit within the core
  2. 1999 High

    Extended EXOSC8's processing role beyond 5.8S rRNA, showing depletion delays 18S and 25S rRNA maturation and causes specific pre-rRNA accumulation, placing it in ribosome biogenesis.

    Evidence Yeast conditional depletion with pulse-chase and northern analysis of pre-rRNA/rRNA

    PMID:9973615

    Open questions at the time
    • Whether processing defects reflect direct catalysis or loss of complex integrity unresolved
    • No link to downstream cellular consequences
  3. 1999 Medium

    Provided the first physical partner and localization, linking Rrp43p to the nucleolar 60S biogenesis factor Nip7p and placing the protein predominantly in the nucleus.

    Evidence Yeast two-hybrid screen, reciprocal IgG-Sepharose co-purification, GFP localization microscopy

    PMID:9891085

    Open questions at the time
    • Functional significance of the Nip7p interaction not tested
    • Interaction not validated in higher eukaryotes
  4. 2002 Medium

    Demonstrated intrinsic catalytic capacity of the human protein, showing OIP2/EXOSC8 has phosphorolytic 3'→5' exoribonuclease activity on precursor tRNA, and linked it to RNase P subunit Rpp14.

    Evidence In vitro exoribonuclease assay on precursor tRNA, immunoprecipitation of crude RNase P complex

    PMID:11929972

    Open questions at the time
    • Single lab, single paper for the activity claim
    • Rpp14 interaction context limited to crude IP
    • Physiological relevance of tRNA processing not established in cells
  5. 2006 Medium

    Defined a sequence-specific RNA recognition mode, showing the RNase PH domain binds ARE/U-rich RNAs, providing a biochemical basis for selective substrate targeting.

    Evidence In vitro RNA binding and competition assays with deletion mutants and homopolymeric RNAs

    PMID:16912217

    Open questions at the time
    • In vitro binding not connected to cellular substrate degradation at this stage
    • Affinity contribution within the assembled complex unknown
  6. 2007 High

    Placed EXOSC8 structurally as a docking interface for the catalytic Rrp44/Dis3 subunit, explaining how the inactive core recruits and regulates catalytic activity.

    Evidence Cryo-EM reconstruction of purified yeast exosome complexes

    PMID:17942686

    Open questions at the time
    • Atomic-resolution interface details limited by cryo-EM resolution
    • Human complex architecture not directly determined here
  7. 2008 Medium

    Distinguished EXOSC8-dependent substrate handling from Rrp6, showing distinct poly(A)+ rRNA degradation intermediates and synergy with Dis3 depletion.

    Evidence Yeast conditional depletion, northern blot, poly(A)+ RNA analysis

    PMID:18940861

    Open questions at the time
    • Mechanistic basis of distinct specificity not resolved
    • Direct versus indirect contribution to substrate processing unclear
  8. 2013 Medium

    Showed EXOSC8 mutations destabilize the nine-subunit complex while increasing exonuclease activity, linking core integrity to activity regulation.

    Evidence TAP purification of WT/mutant Rrp43p, mass spectrometry, in vitro exonuclease assays

    PMID:24237138

    Open questions at the time
    • Whether elevated activity is beneficial or pathological in vivo unknown
    • Single lab
  9. 2014 High

    Connected EXOSC8 loss-of-function to human disease and a specific substrate class, showing mutations cause neurological disease via failed degradation of ARE-containing myelin protein mRNAs.

    Evidence Patient genetics, siRNA knockdown in human oligodendroglia, zebrafish morpholino knockdown, qRT-PCR

    PMID:24989451

    Open questions at the time
    • Direct enzymatic action on myelin mRNAs not shown in vitro
    • How specific missense alleles impair function mechanistically not fully resolved
  10. 2014 Medium

    Identified a developmental regulatory role, showing EXOSC8 is repressed by GATA-1/Foxo3 and acts as an endogenous suppressor of erythroid maturation.

    Evidence Transcriptome analysis and siRNA knockdown in primary erythroid precursors with maturation readout

    PMID:25115889

    Open questions at the time
    • RNA substrates mediating the differentiation block not identified
    • Mechanism distinct from generic exosome loss not established
  11. 2016 Medium

    Placed EXOSC8 in a shared neuronal RNA-metabolism pathway with NEXT complex components, via overlapping transcript changes with RBM7 and phenocopy with exosc3 in zebrafish.

    Evidence RNA-seq of patient fibroblasts, zebrafish morpholino knockdown with phenotypic analysis

    PMID:27193168

    Open questions at the time
    • Direct biochemical link between EXOSC8 and NEXT complex not shown
    • Causal substrates for neuronal phenotype not defined
  12. 2016 Medium

    Identified EXOSC8 as a target of arginine methylation, raising the possibility of post-translational regulation of the subunit.

    Evidence Yeast proteome arrays, ex vivo methylation with recombinant Hmt1, MS/MS validation

    PMID:26572822

    Open questions at the time
    • Functional consequence of methylation on activity or assembly unknown
    • Methylation not confirmed in human EXOSC8
  13. 2020 High

    Linked EXOSC8-dependent ribosome biogenesis to p53 surveillance, showing knockdown stabilizes p53 and induces G2/M arrest and apoptosis across human cells and zebrafish.

    Evidence siRNA knockdown with cell cycle analysis and western blot; zebrafish CRISPR mutants with RNA analysis and apoptosis assays

    PMID:32527837

    Open questions at the time
    • Upstream molecular trigger of p53 stabilization not delineated here
    • Tissue-specificity of apoptotic response not explained
  14. 2020 Medium

    Refined exosome localization, confirming all core subunits including Rrp43 concentrate in the nucleolus, consistent with early pre-rRNA processing.

    Evidence Confocal microscopy of GFP-tagged exosome subunits in live yeast, subcellular fractionation

    PMID:32554806

    Open questions at the time
    • Sub-nucleolar resolution limited
    • Human localization not addressed
  15. 2022 High

    Delineated the mechanistic ribosomal-stress axis, showing EXOSC8 knockdown releases RPL5/RPL11 to sequester Mdm2 and activate p53 in cancer cells and xenografts.

    Evidence EXOSC8 knockdown in CRC cells, western blot, nucleolar/nucleoplasmic fractionation, RPL5/RPL11–Mdm2 co-IP, in vivo xenografts

    PMID:36348012

    Open questions at the time
    • Direct RNA processing defect upstream of RPL release not characterized
    • Generalizability beyond colorectal cancer untested
  16. 2025 Medium

    Resolved nuclear import and precise sub-nucleolar positioning, showing Rrp43 is imported via Srp1/Kap95 importins and enriched in the granular component with Mtr4 and Nop53.

    Evidence Systematic fluorescent tagging and confocal microscopy of all subunits, importin mutant genetics, nucleolar marker co-localization

    PMID:40266794

    Open questions at the time
    • Redundant import pathways not fully mapped
    • Functional consequence of granular-component localization for processing not directly tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how EXOSC8's intrinsic RNA-binding/catalytic properties versus its structural scaffolding role apportion responsibility for specific substrate selection in human cells, and how post-translational modification or tissue context tunes its function.
  • No in vitro reconstitution of human EXOSC8 acting on myelin or NEXT-pathway substrates
  • Functional impact of arginine methylation unknown
  • Mechanism connecting erythroid suppression to specific RNA substrates undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0140098 catalytic activity, acting on RNA 3 GO:0003723 RNA binding 1
Localization
GO:0005634 nucleus 2 GO:0005730 nucleolus 2
Pathway
R-HSA-8953854 Metabolism of RNA 4 R-HSA-1852241 Organelle biogenesis and maintenance 2 R-HSA-5357801 Programmed Cell Death 2
Partners
DIS3EXOSC9HBS1LMTR4NIP7RPP14
Complex memberships
RNA exosome (Exo9 core)

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 Rrp43p (EXOSC8 ortholog) was identified as one of five essential protein components of the yeast 'exosome' complex, a conserved 3'→5' exoribonuclease complex. Rrp43p is homologous to bacterial RNase PH. All exosome components, including Rrp43p, are required for 3' processing of 5.8S rRNA. Biochemical co-purification, mass spectrometry, in vitro exoribonuclease assays, yeast genetics (depletion phenotypes) Cell High 9390555
1999 Rrp43p (EXOSC8 ortholog) depletion in yeast causes deficiency in 40S ribosomes (not 60S), and delays synthesis of both 25S and 18S rRNAs, with accumulation of 35S and 27S pre-rRNAs and under-accumulation of 20S pre-rRNA, demonstrating that Rrp43p is required for maturation of 18S and 25S rRNA in addition to 5.8S rRNA. Yeast depletion genetics, pulse-chase and steady-state northern analysis of pre-RNA and rRNA levels Nucleic acids research High 9973615
1999 Rrp43p (EXOSC8 ortholog) physically interacts with Nip7p (a nucleolar protein required for 60S ribosome biogenesis) as identified by two-hybrid screen and confirmed by co-purification on IgG-Sepharose with protein A-tagged Rrp43p. GFP-Rrp43p localizes throughout the nucleus and to a lesser extent in the cytoplasm. Yeast two-hybrid screen, co-purification (IgG-Sepharose), GFP localization microscopy Molecular and cellular biology Medium 9891085
2002 OIP2 (EXOSC8) physically interacts with the human RNase P subunit Rpp14, and OIP2 possesses 3'→5' exoribonuclease activity with a phosphorolytic mechanism that processes the 3' terminus of precursor tRNA in vitro. In vitro exoribonuclease assay with precursor tRNA substrate, immunoprecipitation of crude RNase P complex Proceedings of the National Academy of Sciences of the United States of America Medium 11929972
2006 The RNase PH domain of OIP2 (EXOSC8) specifically binds to AU-rich element (ARE)-containing RNAs with similar affinity to other RNase PH domain-containing exosome components. This sequence-specific RNA binding is competed by poly(U) but not other homopolymeric RNAs, indicating affinity for U- and AU-rich sequences. RNA binding assays with deletion mutants, competition assays with homopolymeric RNAs, in vitro pull-down RNA (New York, N.Y.) Medium 16912217
2007 Cryo-EM reconstruction of the yeast exosome shows that Rrp44 (Dis3p) anchors to the exosome core primarily through interactions with Rrp45 and Rrp43 (EXOSC8 ortholog) subunits, defining the structural architecture of the Rrp44-exosome complex and suggesting an active-site sequestration mechanism for control of exoribonuclease activity. Cryo-EM reconstruction of purified exosome complexes Proceedings of the National Academy of Sciences of the United States of America High 17942686
2008 Rrp43p (EXOSC8 ortholog) depletion in yeast causes accumulation of poly(A)+ rRNA degradation intermediates distinct from those found in cells lacking Rrp6p, establishing Rrp43p as a core exosome component with a distinct substrate specificity compared to Rrp6p. Combined depletion of Dis3p in rrp43 mutant background causes synergistic increases in degradation substrates. Yeast genetics (conditional depletion), northern blot, poly(A)+ RNA analysis Nucleic acids research Medium 18940861
2013 Mutations in the exosome core subunit Rrp43p (EXOSC8 ortholog) decrease the stability of the nine-subunit exosome complex, as shown by reduced co-purification of other exosome subunits with mutant Rrp43p. Mutant Rrp43p complexes exhibit increased exonuclease activity, suggesting higher dissociation constants. TAP purification of wild-type and mutant Rrp43p, mass spectrometry, in vitro exonuclease activity assays Journal of proteome research Medium 24237138
2014 Homozygous missense mutations in EXOSC8 cause progressive neurological disease in humans. Experimental downregulation of EXOSC8 in human oligodendroglia cells and zebrafish causes a specific increase in ARE-containing mRNAs encoding myelin proteins (e.g., MBP, PLP), demonstrating that EXOSC8 normally degrades these ARE mRNAs and that imbalanced myelin protein supply disrupts myelination. Patient genetics, siRNA knockdown in human oligodendroglia cells, zebrafish morpholino knockdown, qRT-PCR and mRNA level quantification Nature communications High 24989451
2014 GATA-1/Foxo3 transcription factors repress expression of Exosc8 during erythroid differentiation, and downregulation of Exosc8 (or other exosome components) in primary erythroid precursor cells induces erythroid cell maturation, establishing EXOSC8 as an endogenous suppressor of the erythroid developmental program. Transcriptome analysis of GATA-1/Foxo3-dependent gene expression, siRNA knockdown of Exosc8 in primary erythroid precursor cells with maturation readout Blood Medium 25115889
2017 HBS1LV3 (a short isoform of HBS1L) may interact with the exosome core subunit RRP43 (EXOSC8) via a conserved RxxxFxxxL motif to link the exosome and SKI complexes in the human cytoplasm, in a manner analogous to the Rrp6-Rrp43 interaction in yeast. Proteomic analysis (co-immunoprecipitation/mass spectrometry), interaction domain mapping Nucleic acids research Low 28204585
2016 RNA-seq of fibroblasts from patients with EXOSC8 mutations identified 62 transcripts with significantly altered expression shared with RBM7 mutant patient cells, and knockdown of exosc8 in zebrafish showed a common pattern of motor neuron and cerebellar defects with exosc3 knockdown, placing EXOSC8 in the same functional pathway as the NEXT complex in neuronal RNA metabolism. RNA-sequencing of patient fibroblasts, zebrafish morpholino knockdown with phenotypic analysis Human molecular genetics Medium 27193168
2020 Knockdown of EXOSC8 in human cells leads to p53 protein stabilization and G2/M cell cycle arrest. In zebrafish with homozygous exosc8 mutations, mRNAs encoding p53 and ribosome biogenesis factors are increased, and mutant zebrafish show increased apoptosis during brain development, linking EXOSC8 function to ribosome biogenesis and p53-dependent signaling. siRNA knockdown in human cells with cell cycle analysis and western blot; zebrafish CRISPR/Cas9 homozygous mutant lines with RNA analysis and apoptosis assays Life science alliance High 32527837
2020 All yeast exosome core subunits including Rrp43 (EXOSC8 ortholog) localize predominantly to the nucleus and concentrate strongly in the nucleolus, as determined by live confocal microscopy of GFP-tagged subunits, consistent with a primary role in early pre-rRNA processing. Confocal microscopy of GFP-tagged exosome subunits in live yeast cells, subcellular fractionation The Journal of biological chemistry Medium 32554806
2022 EXOSC8 knockdown in colorectal cancer cells triggers ribosomal stress: RPL5 and RPL11 are released from the nucleolus into the nucleoplasm, where they 'hijack' Mdm2 to block its E3 ubiquitin ligase function, thereby stabilizing and activating p53. This mechanism links EXOSC8-dependent ribosome biogenesis to the RPL5/RPL11-Mdm2-p53 surveillance pathway. EXOSC8 knockdown in CRC cells, western blot for p53/Mdm2/RPL5/RPL11, nucleolar/nucleoplasmic fractionation, co-immunoprecipitation of RPL5/RPL11 with Mdm2, in vivo xenograft experiments Oncogene High 36348012
2025 In budding yeast, all Exo9 core subunits including Rrp43 (EXOSC8 ortholog) are imported into the nucleus via importins Srp1 (α) and Kap95 (β). Within the nucleus, Rrp43 is enriched in the granular component of the nucleolus in the same region as Mtr4 and Nop53, cofactors involved in rRNA processing. Nuclear localization of Exo9 does not depend solely on NLS-containing subunits Rrp6 or Rrp44, suggesting redundant import pathways. Systematic GFP/fluorescent tagging and confocal microscopy of all exosome subunits, genetic importin mutant analysis, co-localization with known nucleolar markers Molecular biology of the cell Medium 40266794
2016 Rrp43p (EXOSC8 ortholog) is a substrate of the yeast arginine methyltransferase Hmt1, as validated by ex vivo methylation and MS/MS analysis, identifying EXOSC8 as a target of arginine methylation. Yeast proteome arrays, ex vivo methylation with recombinant Hmt1, MS/MS validation Proteomics Medium 26572822

Source papers

Stage 0 corpus · 55 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1997 The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. Cell 808 9390555
2006 TOS9 regulates white-opaque switching in Candida albicans. Eukaryotic cell 173 16950924
2014 EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia. Nature communications 119 24989451
2017 The RNA exosome and RNA exosome-linked disease. RNA (New York, N.Y.) 118 29093021
2014 Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2). The Journal of biological chemistry 101 24808172
2007 Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing. Proceedings of the National Academy of Sciences of the United States of America 92 17942686
2008 Evidence for core exosome independent function of the nuclear exoribonuclease Rrp6p. Nucleic acids research 86 18940861
2017 Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression. BMC cancer 84 28403887
2020 Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities. Nature communications 83 32433464
1999 Nip7p interacts with Nop8p, an essential nucleolar protein required for 60S ribosome biogenesis, and the exosome subunit Rrp43p. Molecular and cellular biology 79 9891085
2016 Mutations in EXOSC2 are associated with a novel syndrome characterised by retinitis pigmentosa, progressive hearing loss, premature ageing, short stature, mild intellectual disability and distinctive gestalt. Journal of medical genetics 75 26843489
2018 Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy. American journal of human genetics 71 29727687
2004 Characterization of Saccharomyces cerevisiae Nop17p, a novel Nop58p-interacting protein that is involved in Pre-rRNA processing. Journal of molecular biology 66 15670595
1999 The exosome subunit Rrp43p is required for the efficient maturation of 5.8S, 18S and 25S rRNA. Nucleic acids research 62 9973615
2014 The exosome complex establishes a barricade to erythroid maturation. Blood 55 25115889
2020 The RNA Exosome and Human Disease. Methods in molecular biology (Clifton, N.J.) 54 31768969
2019 Comprehensive characterization of the rRNA metabolism-related genes in human cancer. Oncogene 46 31548613
2017 A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans. Nucleic acids research 39 28204585
2016 Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy. Human molecular genetics 39 27193168
2006 Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. RNA (New York, N.Y.) 32 16912217
2018 Pontocerebellar hypoplasia type 1 for the neuropediatrician: Genotype-phenotype correlations and diagnostic guidelines based on new cases and overview of the literature. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 28 29656927
2001 Osteoclast inhibitory peptide 2 inhibits osteoclast formation via its C-terminal fragment. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 28 11585344
1996 Molecular characterization of Euglena ascorbate peroxidase using monoclonal antibody. Biochimica et biophysica acta 27 8645709
2021 Bi-allelic missense variant, p.Ser35Leu in EXOSC1 is associated with pontocerebellar hypoplasia. Clinical genetics 25 33463720
2020 RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels. Life science alliance 25 32527837
2013 Dillenia Suffruticosa extract inhibits proliferation of human breast cancer cell lines (MCF-7 and MDA-MB-231) via induction of G2/M arrest and apoptosis. Molecules (Basel, Switzerland) 25 24172241
2005 Identification of Candida albicans genes that induce Saccharomyces cerevisiae cell adhesion and morphogenesis. Biotechnology progress 25 16321041
2016 TMV induces RNA decay pathways to modulate gene silencing and disease symptoms. The Plant journal : for cell and molecular biology 22 27599263
2022 EXOSC8 promotes colorectal cancer tumorigenesis via regulating ribosome biogenesis-related processes. Oncogene 20 36348012
2002 A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity. Proceedings of the National Academy of Sciences of the United States of America 19 11929972
2015 Respiratory chain deficiency in nonmitochondrial disease. Neurology. Genetics 17 27066545
2019 The RNA degradation pathway is involved in PPARα-modulated anti-oral tumorigenesis. BioMedicine 15 31724941
2013 A new strategy for gene targeting and functional proteomics using the DT40 cell line. Nucleic acids research 14 23892402
2021 Risk of sudden cardiac death in EXOSC5-related disease. American journal of medical genetics. Part A 12 34089229
2007 Structural insights into the interaction of the Nip7 PUA domain with polyuridine RNA. Biochemistry 12 18001138
2021 A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency. mBio 11 34872356
2023 ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells. Cell reports 10 37851577
2020 Nucleolar localization of the yeast RNA exosome subunit Rrp44 hints at early pre-rRNA processing as its main function. The Journal of biological chemistry 10 32554806
1994 Treatment of gastric adenocarcinoma with the combination of etoposide, adriamycin and cisplatin (EAP): comparison between two schedules. Oncology 10 8265093
2016 Protein substrates of the arginine methyltransferase Hmt1 identified by proteome arrays. Proteomics 9 26572822
2023 The Rat Brain Transcriptome: From Infancy to Aging and Sporadic Alzheimer's Disease-like Pathology. International journal of molecular sciences 8 36674977
2013 Proteomic analysis of yeast mutant RNA exosome complexes. Journal of proteome research 7 24237138
2021 13q Deletion Syndrome Involving RB1: Characterization of a New Minimal Critical Region for Psychomotor Delay. Genes 6 34573300
2023 Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family. The Journal of biological chemistry 5 36736422
2019 Influence of exogenous acid protease in broiler chickens fed corn-soybean meal-based diets. Journal of animal physiology and animal nutrition 5 31762103
2024 S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases. The Journal of biological chemistry 4 39098536
2023 A missense variant in EXOSC8 causes exon skipping and expands the phenotypic spectrum of pontocerebellar hypoplasia type 1C. Journal of human genetics 4 38017281
2021 New subtype of PCH1C caused by novel EXOSC8 variants in a 16-year-old Spanish patient. Neuromuscular disorders : NMD 4 34210538
2022 Prostate-derived IL-1β upregulates expression of NMDA receptor in the paraventricular nucleus and shortens ejaculation latency in rats with experimental autoimmune prostatitis. Asian journal of andrology 3 34396994
2021 Detection of Melanogenesis and Anti-Apoptosis-Associated Melanoma Factors: Array CGH and PPI Mapping Integrating Study. Protein and peptide letters 3 34749602
2018 Genetic Analysis of Undiagnosed Juvenile GM1-Gangliosidosis by Microarray and Exome Sequencing. Case reports in genetics 2 30581635
2025 New insights into nuclear import and nucleolar localization of yeast RNA exosome subunits. Molecular biology of the cell 1 40266794
2025 Disrupted maxillofacial, cardiovascular, and nervous development in washc5 knockout Zebrafish: Insights into 3C syndrome. Gene 0 39988189
2025 Pontocerebellar Hypoplasia Type 1 and Associated Neuronopathies. Genes 0 40428407
2025 [Molecular and Genetic Analysis of a Rare Primary Culture of Head and Neck Paraganglioma]. Molekuliarnaia biologiia 0 41477719

Missed literature

Know a paper Affinage missed for EXOSC8? Flag it for the maintainers and the community.

No submissions yet.