Affinage

EXOSC8

Exosome complex component RRP43 · UniProt Q96B26

Length
276 aa
Mass
30.0 kDa
Annotated
2026-04-28
56 papers in source corpus 15 papers cited in narrative 15 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

EXOSC8 (yeast Rrp43p) is a structural core subunit of the nine-subunit RNA exosome complex that functions in 3′→5′ RNA processing and degradation, with roles spanning rRNA maturation, AU-rich element (ARE)-containing mRNA turnover, and ribosome biogenesis surveillance. Its RNase PH domain forms part of the barrel-shaped exosome ring and directly binds ARE-containing RNAs with sequence specificity, and its integrity is required for overall complex stability and regulated exonuclease activity (PMID:9390555, PMID:16912217, PMID:17942686, PMID:24237138). Loss of EXOSC8 impairs 5.8S, 18S, and 25S rRNA processing, stabilizes ARE-bearing myelin protein mRNAs in oligodendrocytes, and triggers ribosomal stress that activates the RPL5/RPL11–Mdm2–p53 axis leading to G2/M arrest and apoptosis (PMID:9973615, PMID:24989451, PMID:32527837, PMID:36348012). Homozygous missense mutations in EXOSC8 cause a progressive cerebellar and motor neuron degenerative disease linked to defective ARE-mRNA degradation and myelin protein imbalance (PMID:24989451).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1997 High

    Identification of EXOSC8 (Rrp43p) as a component of a conserved multi-subunit exosome complex with 3′→5′ exoribonuclease activity established it as part of a fundamental RNA degradation machine required for 5.8S rRNA 3′ processing.

    Evidence Protein complex purification, mass spectrometry, in vitro phosphorolytic exonuclease assays, and genetic complementation in yeast

    PMID:9390555

    Open questions at the time
    • Whether Rrp43p itself possesses catalytic activity or contributes structurally
    • Identity of the full substrate range beyond 5.8S rRNA
  2. 1999 High

    Depletion studies revealed that Rrp43p is required not only for 5.8S rRNA but also for 18S and 25S rRNA maturation, broadening its role to general ribosome biogenesis, and identified physical partners Nip7p and Nop8p.

    Evidence Conditional depletion with pulse-chase northern analysis and co-immunoprecipitation in yeast

    PMID:9891085 PMID:9973615

    Open questions at the time
    • Mechanism by which Rrp43p depletion impairs 18S processing specifically
    • Functional significance of Nip7p/Nop8p interactions
  3. 2002 High

    Demonstration that human EXOSC8 (OIP2) interacts with RNase P subunit Rpp14 and together exhibits phosphorolytic 3′→5′ exonuclease activity on precursor tRNA extended its substrate repertoire to tRNA processing.

    Evidence Co-immunoprecipitation and in vitro exoribonuclease assay with precursor tRNA substrate in human cells

    PMID:11929972

    Open questions at the time
    • Whether this activity is intrinsic to EXOSC8 or conferred by the Rpp14 partner
    • In vivo relevance of tRNA substrate processing by this complex
  4. 2006 High

    Mapping the RNA-binding specificity of EXOSC8 revealed that its RNase PH domain directly and specifically binds AU-rich element (ARE)-containing RNAs, identifying the molecular basis for exosome recruitment to ARE-mRNA substrates.

    Evidence Deletion mutagenesis and RNA binding/competition assays with recombinant protein

    PMID:16912217

    Open questions at the time
    • Whether ARE binding by EXOSC8 is sufficient for exosome targeting in vivo
    • Structural basis of ARE recognition by the RNase PH domain
  5. 2007 High

    EM reconstruction of the yeast exosome placed Rrp43p within the RNase PH ring and showed it anchors the Rrp44 catalytic subunit, explaining how the structural core channels substrates to the active site.

    Evidence Electron microscopy reconstruction of purified nine-subunit complex

    PMID:17942686

    Open questions at the time
    • Atomic-resolution contacts between Rrp43 and Rrp44
    • How substrate RNA threads through the barrel past Rrp43
  6. 2013 Medium

    Mutations in Rrp43p destabilize the nine-subunit core and paradoxically increase exonuclease activity, establishing that EXOSC8 integrity constrains catalytic output and maintains complex architecture.

    Evidence TAP purification, mass spectrometry, and in vitro exonuclease assay of mutant complexes in yeast

    PMID:24237138

    Open questions at the time
    • Which specific Rrp43 residues are critical for stability versus activity regulation
    • Whether increased activity reflects altered Rrp44 positioning or loss of gating
  7. 2014 High

    Causative homozygous EXOSC8 mutations in patients with progressive neurodegeneration, combined with knockdown in oligodendroglia and zebrafish, demonstrated that EXOSC8-dependent ARE-mRNA degradation is essential for myelin protein homeostasis and nervous system integrity.

    Evidence Patient genetics across multiple pedigrees, siRNA knockdown in human oligodendroglia, zebrafish morpholino knockdown, qRT-PCR and RNA-seq

    PMID:24989451

    Open questions at the time
    • Whether myelin mRNA accumulation is the primary or sole driver of neurodegeneration
    • Cell-type specificity of vulnerability beyond oligodendrocytes
  8. 2014 Medium

    Discovery that GATA-1 and Foxo3 cooperatively repress EXOSC8 during erythropoiesis, and that EXOSC8 knockdown promotes erythroid differentiation, revealed the exosome as an endogenous suppressor of erythroid lineage commitment.

    Evidence Transcriptome analysis, shRNA knockdown in primary erythroid precursor cells, flow cytometry differentiation assay

    PMID:25115889

    Open questions at the time
    • Identity of the specific RNA targets whose stabilization drives erythroid maturation
    • Whether this is a direct transcriptional program or secondary to ribosomal stress
  9. 2016 Medium

    Parallel knockdown of EXOSC8 and RBM7 in zebrafish produced overlapping motor neuron and cerebellar defects, and patient fibroblasts shared 62 altered transcripts, functionally linking EXOSC8 to the NEXT complex RNA surveillance pathway.

    Evidence Zebrafish morpholino knockdown, RNA-seq of patient fibroblasts with EXOSC8 or RBM7 mutations

    PMID:27193168

    Open questions at the time
    • Direct physical interaction between EXOSC8-containing exosome and NEXT complex components
    • Which of the 62 shared transcripts are causal for the neurological phenotype
  10. 2020 High

    Loss of EXOSC8 in human cells and zebrafish was shown to activate the ribosome biogenesis–p53 surveillance pathway, causing p53 stabilization, G2/M arrest, and increased apoptosis with reduced brain size, mechanistically connecting exosome dysfunction to a defined cell death program.

    Evidence siRNA knockdown in human cells, CRISPR zebrafish mutants, immunoblot, flow cytometry cell cycle analysis, RNA-seq

    PMID:32527837

    Open questions at the time
    • Whether p53 activation is solely responsible for the neurodegenerative phenotype or acts alongside other pathways
    • Relative contribution of rRNA processing defects versus mRNA stabilization to p53 induction
  11. 2020 Medium

    Localization of all yeast exosome core subunits including Rrp43 to the nucleolus, with nuclear import dependent on importins Srp1/Kap95, established the import machinery and subnuclear concentration site for the exosome.

    Evidence Confocal microscopy of GFP-tagged subunits, genetic importin mutants, co-localization with nucleolar markers in yeast

    PMID:32554806

    Open questions at the time
    • Whether human EXOSC8 uses the same import pathway
    • Mechanism of cytoplasmic retention by Ski7
  12. 2022 High

    The molecular mechanism linking EXOSC8 loss to p53 was resolved: ribosomal stress causes RPL5/RPL11 release from the nucleolus to sequester Mdm2, blocking p53 ubiquitination; this axis was validated in vivo in xenograft tumors.

    Evidence siRNA knockdown, co-immunoprecipitation of RPL5/RPL11–Mdm2, immunofluorescence, p53 reporter assays, and xenograft mouse model in colorectal cancer cells

    PMID:36348012

    Open questions at the time
    • Whether this mechanism operates in neurons and oligodendrocytes relevant to EXOSC8 disease
    • Identity of the specific rRNA processing defect that triggers RPL5/RPL11 release
  13. 2025 Medium

    Refined subnucleolar mapping placed Rrp43 specifically in the granular component alongside cofactors Mtr4 and Nop53, and demonstrated redundant nuclear import pathways when NLS-containing catalytic subunits are absent.

    Evidence Confocal microscopy, FRAP, importin deletion mutants, co-localization with GC/DFC markers in yeast

    PMID:40266794

    Open questions at the time
    • Whether GC localization reflects the primary site of rRNA processing by the exosome
    • Functional significance of redundant import pathways for exosome assembly

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the atomic-resolution structural basis for ARE recognition by the EXOSC8 RNase PH domain, the cell-type-specific RNA targets whose misregulation drives neurodegeneration versus erythroid phenotypes, and whether the ribosomal stress–p53 pathway or ARE-mRNA accumulation is the dominant driver of oligodendrocyte loss in EXOSC8-mutant patients.
  • No high-resolution structure of EXOSC8 bound to ARE RNA
  • Causal hierarchy of rRNA processing defect versus ARE-mRNA stabilization in disease
  • Lack of conditional knockout models in mammalian neural lineages

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 3 GO:0003723 RNA binding 2 GO:0016787 hydrolase activity 2
Localization
GO:0005634 nucleus 2 GO:0005730 nucleolus 2 GO:0005829 cytosol 2
Pathway
R-HSA-8953854 Metabolism of RNA 5 R-HSA-392499 Metabolism of proteins 3 R-HSA-1640170 Cell Cycle 2 R-HSA-5357801 Programmed Cell Death 2
Partners
DIS3EXOSC4NIP7NOP8RPL11RPL5RPP14
Complex memberships
RNA exosome (Exo-10/Exo-11 nuclear)RNA exosome (Exo-9 core)

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 EXOSC8 (yeast ortholog Rrp43p) is a component of the conserved eukaryotic 'exosome' multi-protein complex; recombinant Rrp41p (a related subunit) exhibits phosphorolytic 3'→5' exoribonuclease activity in vitro, and all exosome components including Rrp43p are required for 3' processing of 5.8S rRNA. Protein complex purification, mass spectrometry, in vitro exoribonuclease assays, genetic complementation Cell High 9390555
1999 Yeast Rrp43p (EXOSC8 ortholog) co-purifies with Nip7p and Nop8p by co-immunoprecipitation, and depletion of Rrp43p causes deficiency in 40S ribosomes and delays in synthesis of both 25S and 18S rRNAs, with accumulation of 35S and 27S pre-rRNAs and under-accumulation of 20S pre-rRNA, indicating a role in maturation of 18S and 25S rRNA in addition to 5.8S rRNA. Conditional depletion, pulse-chase northern analysis, co-immunoprecipitation Nucleic acids research High 9891085 9973615
1999 Yeast Rrp43p (EXOSC8 ortholog) physically interacts with Nip7p (a nucleolar ribosome biogenesis factor) and co-purifies with Nop8p; GFP-Rrp43p localizes throughout the nucleus and to a lesser extent in the cytoplasm, distinct from nucleolar Nip7p and Nop8p. Two-hybrid screen, co-purification on IgG-Sepharose, GFP localization Molecular and cellular biology Medium 9891085
2002 Human OIP2 (EXOSC8) interacts with the human RNase P subunit Rpp14 and together they exhibit 3'→5' exoribonuclease activity with phosphorolytic mechanism, capable of processing the 3' terminus of precursor tRNA. Co-immunoprecipitation, in vitro exoribonuclease assay with precursor tRNA substrate Proceedings of the National Academy of Sciences of the United States of America High 11929972
2006 The RNase PH domain of OIP2 (EXOSC8) specifically binds AU-rich element (ARE)-containing RNAs; this sequence-specific interaction is competed by poly(U) but not other homopolymers, implicating the RNase PH domain as the ARE-binding module of the exosome. Deletion mutagenesis, RNA binding/competition assays with recombinant protein RNA (New York, N.Y.) High 16912217
2007 EM reconstruction of the yeast core exosome places Rrp43p (EXOSC8 ortholog) as part of the RNase PH-ring forming the barrel of the nine-subunit core complex; the Rrp44 C-terminal exonuclease domain is anchored principally to Rrp45 and Rrp43 subunits, defining the structural basis for active-site sequestration. Electron microscopy reconstruction, structural analysis of purified complex Proceedings of the National Academy of Sciences of the United States of America High 17942686
2013 Mutations in the yeast exosome core subunit Rrp43p (EXOSC8 ortholog) decrease the stability of the nine-subunit core complex (as shown by reduced co-purification of other subunits), and mutant Rrp43p-containing complexes exhibit increased exonuclease activity, indicating that Rrp43p integrity is required for normal complex stability and activity regulation. TAP purification, mass spectrometry, in vitro exonuclease assay Journal of proteome research Medium 24237138
2014 Homozygous missense mutations in EXOSC8 (an essential exosome core protein) cause progressive neurological disease; experimental downregulation of EXOSC8 in human oligodendroglia cells and zebrafish specifically increases ARE-containing mRNAs encoding myelin proteins (e.g., PLP1, MBP), demonstrating that EXOSC8-dependent exosomal degradation of ARE-mRNAs is required to maintain correct myelin protein balance. Patient genetics, siRNA knockdown in human oligodendroglia cells, zebrafish morpholino knockdown, qRT-PCR/RNA-seq Nature communications High 24989451
2014 GATA-1 and Foxo3 cooperatively repress Exosc8 expression during erythroid differentiation; knockdown of Exosc8 (or other exosome components) in primary erythroid precursor cells induces erythroid maturation, establishing the exosome complex as an endogenous suppressor of the erythroid developmental program. Transcriptome analysis, shRNA knockdown in primary erythroid precursor cells, flow cytometry differentiation assay Blood Medium 25115889
2016 Knockdown of exosc8 in zebrafish recapitulates motor neuron and cerebellar defects seen with rbm7 knockdown; RNA-seq of patient fibroblasts with EXOSC8 or RBM7 mutations identified 62 shared altered transcripts, placing EXOSC8 in the same RNA metabolic pathway as the NEXT complex. Zebrafish morpholino knockdown, RNA-seq of patient fibroblasts, genetic epistasis Human molecular genetics Medium 27193168
2020 Downregulation of EXOSC8 in human cells leads to p53 protein stabilization and G2/M cell cycle arrest; in zebrafish with homozygous exosc8 mutations, increased levels of mRNAs encoding p53 and ribosome biogenesis factors are observed, with increased apoptosis causing reduced brain and cerebellum size, linking EXOSC8 function to the ribosome biogenesis-p53 surveillance pathway. siRNA knockdown in human cells, CRISPR/zebrafish mutant lines, immunoblot, flow cytometry cell cycle analysis, RNA-seq Life science alliance High 32527837
2020 Allele-specific inactivation of EXOSC8 (targeting one SNP allele) reduces growth of cells harboring that allele while cells harboring the non-targeted allele remain intact, demonstrating that EXOSC8 is an essential gene whose allelic differences can be exploited for selective cancer cell killing. Allele-specific siRNA/gene-editing in isogenic cell lines, cell growth assay Nature communications Medium 32433464
2020 All subunits of the yeast exosome core (Exo9), including Rrp43 (EXOSC8 ortholog), concentrate in the nucleolus as shown by confocal microscopy; nuclear import of Exo9 subunits is mediated by importins Srp1 (α) and Kap95 (β), and Ski7 plays a role in retention of Exo9 in the cytoplasm. Confocal fluorescence microscopy of GFP-tagged subunits, genetic importin mutants, co-localization with nucleolar markers The Journal of biological chemistry Medium 32554806
2022 EXOSC8 knockdown in colorectal cancer cells triggers ribosomal stress, causing nucleolar RPL5/RPL11 release into the nucleoplasm where they 'hijack' Mdm2 to block its E3 ubiquitin ligase function, thereby stabilizing and activating p53; the oncogenic proliferation phenotype of EXOSC8 depends on p53 both in vitro and in vivo. siRNA knockdown, immunofluorescence (nucleolar protein redistribution), co-immunoprecipitation (RPL5/RPL11-Mdm2), p53 reporter assays, xenograft mouse model Oncogene High 36348012
2025 Yeast Rrp43 (EXOSC8 ortholog) localizes specifically to the granular component of the nucleolus and co-enriches with nuclear exosome cofactors Mtr4 and Nop53 in this subnucleolar region; nuclear import of Exo9 subunits requires importins Srp1/Kap95, with redundant import pathways when NLS-containing subunits Rrp6 and Rrp44 are absent. Confocal microscopy, FRAP, importin deletion mutants, co-localization with GC/DFC markers Molecular biology of the cell Medium 40266794

Source papers

Stage 0 corpus · 56 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1997 The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. Cell 807 9390555
2006 TOS9 regulates white-opaque switching in Candida albicans. Eukaryotic cell 173 16950924
2014 EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia. Nature communications 119 24989451
2017 The RNA exosome and RNA exosome-linked disease. RNA (New York, N.Y.) 116 29093021
2014 Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2). The Journal of biological chemistry 100 24808172
2007 Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing. Proceedings of the National Academy of Sciences of the United States of America 92 17942686
2008 Evidence for core exosome independent function of the nuclear exoribonuclease Rrp6p. Nucleic acids research 86 18940861
2017 Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression. BMC cancer 83 28403887
2020 Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities. Nature communications 82 32433464
1999 Nip7p interacts with Nop8p, an essential nucleolar protein required for 60S ribosome biogenesis, and the exosome subunit Rrp43p. Molecular and cellular biology 79 9891085
2016 Mutations in EXOSC2 are associated with a novel syndrome characterised by retinitis pigmentosa, progressive hearing loss, premature ageing, short stature, mild intellectual disability and distinctive gestalt. Journal of medical genetics 74 26843489
2018 Variants in EXOSC9 Disrupt the RNA Exosome and Result in Cerebellar Atrophy with Spinal Motor Neuronopathy. American journal of human genetics 71 29727687
2004 Characterization of Saccharomyces cerevisiae Nop17p, a novel Nop58p-interacting protein that is involved in Pre-rRNA processing. Journal of molecular biology 66 15670595
1999 The exosome subunit Rrp43p is required for the efficient maturation of 5.8S, 18S and 25S rRNA. Nucleic acids research 62 9973615
2014 The exosome complex establishes a barricade to erythroid maturation. Blood 54 25115889
2020 The RNA Exosome and Human Disease. Methods in molecular biology (Clifton, N.J.) 52 31768969
1997 Eucalyptus has functional equivalents of the Arabidopsis AP1 gene. Plant molecular biology 48 9349279
2019 Comprehensive characterization of the rRNA metabolism-related genes in human cancer. Oncogene 46 31548613
2017 A short splicing isoform of HBS1L links the cytoplasmic exosome and SKI complexes in humans. Nucleic acids research 39 28204585
2016 Altered RNA metabolism due to a homozygous RBM7 mutation in a patient with spinal motor neuropathy. Human molecular genetics 39 27193168
2006 Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. RNA (New York, N.Y.) 32 16912217
2001 Osteoclast inhibitory peptide 2 inhibits osteoclast formation via its C-terminal fragment. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 28 11585344
1996 Molecular characterization of Euglena ascorbate peroxidase using monoclonal antibody. Biochimica et biophysica acta 27 8645709
2018 Pontocerebellar hypoplasia type 1 for the neuropediatrician: Genotype-phenotype correlations and diagnostic guidelines based on new cases and overview of the literature. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 26 29656927
2020 RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels. Life science alliance 25 32527837
2013 Dillenia Suffruticosa extract inhibits proliferation of human breast cancer cell lines (MCF-7 and MDA-MB-231) via induction of G2/M arrest and apoptosis. Molecules (Basel, Switzerland) 25 24172241
2005 Identification of Candida albicans genes that induce Saccharomyces cerevisiae cell adhesion and morphogenesis. Biotechnology progress 25 16321041
2021 Bi-allelic missense variant, p.Ser35Leu in EXOSC1 is associated with pontocerebellar hypoplasia. Clinical genetics 24 33463720
2016 TMV induces RNA decay pathways to modulate gene silencing and disease symptoms. The Plant journal : for cell and molecular biology 22 27599263
2022 EXOSC8 promotes colorectal cancer tumorigenesis via regulating ribosome biogenesis-related processes. Oncogene 20 36348012
2002 A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity. Proceedings of the National Academy of Sciences of the United States of America 19 11929972
2015 Respiratory chain deficiency in nonmitochondrial disease. Neurology. Genetics 17 27066545
2019 The RNA degradation pathway is involved in PPARα-modulated anti-oral tumorigenesis. BioMedicine 15 31724941
2013 A new strategy for gene targeting and functional proteomics using the DT40 cell line. Nucleic acids research 14 23892402
2021 Risk of sudden cardiac death in EXOSC5-related disease. American journal of medical genetics. Part A 12 34089229
2007 Structural insights into the interaction of the Nip7 PUA domain with polyuridine RNA. Biochemistry 12 18001138
2021 A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency. mBio 11 34872356
2020 Nucleolar localization of the yeast RNA exosome subunit Rrp44 hints at early pre-rRNA processing as its main function. The Journal of biological chemistry 10 32554806
1994 Treatment of gastric adenocarcinoma with the combination of etoposide, adriamycin and cisplatin (EAP): comparison between two schedules. Oncology 10 8265093
2016 Protein substrates of the arginine methyltransferase Hmt1 identified by proteome arrays. Proteomics 9 26572822
2023 The Rat Brain Transcriptome: From Infancy to Aging and Sporadic Alzheimer's Disease-like Pathology. International journal of molecular sciences 8 36674977
2023 ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells. Cell reports 8 37851577
2013 Proteomic analysis of yeast mutant RNA exosome complexes. Journal of proteome research 7 24237138
2021 13q Deletion Syndrome Involving RB1: Characterization of a New Minimal Critical Region for Psychomotor Delay. Genes 6 34573300
2023 Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family. The Journal of biological chemistry 5 36736422
2019 Influence of exogenous acid protease in broiler chickens fed corn-soybean meal-based diets. Journal of animal physiology and animal nutrition 5 31762103
2023 A missense variant in EXOSC8 causes exon skipping and expands the phenotypic spectrum of pontocerebellar hypoplasia type 1C. Journal of human genetics 4 38017281
2021 New subtype of PCH1C caused by novel EXOSC8 variants in a 16-year-old Spanish patient. Neuromuscular disorders : NMD 4 34210538
2024 S. aureus Eap is a polyvalent inhibitor of neutrophil serine proteases. The Journal of biological chemistry 3 39098536
2022 Prostate-derived IL-1β upregulates expression of NMDA receptor in the paraventricular nucleus and shortens ejaculation latency in rats with experimental autoimmune prostatitis. Asian journal of andrology 3 34396994
2021 Detection of Melanogenesis and Anti-Apoptosis-Associated Melanoma Factors: Array CGH and PPI Mapping Integrating Study. Protein and peptide letters 3 34749602
2018 Genetic Analysis of Undiagnosed Juvenile GM1-Gangliosidosis by Microarray and Exome Sequencing. Case reports in genetics 2 30581635
2025 New insights into nuclear import and nucleolar localization of yeast RNA exosome subunits. Molecular biology of the cell 1 40266794
2025 Disrupted maxillofacial, cardiovascular, and nervous development in washc5 knockout Zebrafish: Insights into 3C syndrome. Gene 0 39988189
2025 Pontocerebellar Hypoplasia Type 1 and Associated Neuronopathies. Genes 0 40428407
2025 [Molecular and Genetic Analysis of a Rare Primary Culture of Head and Neck Paraganglioma]. Molekuliarnaia biologiia 0 41477719