Affinage

ERC1

ELKS/Rab6-interacting/CAST family member 1 · UniProt Q8IUD2

Length
1116 aa
Mass
128.1 kDa
Annotated
2026-04-28
52 papers in source corpus 24 papers cited in narrative 24 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ERC1 (ELKS) is a coiled-coil scaffold protein that organizes macromolecular assemblies at sites of regulated exocytosis, cell migration, and NF-κB signaling. At presynaptic active zones, ERC1 directly binds RIM, Bassoon, liprin-α, and voltage-dependent Ca²⁺ channel (VDCC) β subunits, controlling Ca²⁺ channel density, readily releasable pool size, and neurotransmitter release probability; combined deletion of CAST/ELKS in forebrain neurons causes neonatal lethality (PMID:14723704, PMID:25209271, PMID:29996090, PMID:32304329). ERC1 undergoes liquid–liquid phase separation driven by its N-terminal intrinsically disordered region; these condensates recruit liprin-α, LL5β, and Rab6B-coated vesicles to regulate focal adhesion turnover, integrin internalization, and vesicle exocytosis at the leading edge and secretory sites (PMID:31537859, PMID:37172719, PMID:24982445, PMID:40646182). In pancreatic β-cells, ERC1 interacts with L-type VDCC β subunits to polarize Ca²⁺ influx at the vascular-facing membrane and enable first-phase glucose-stimulated insulin secretion (PMID:30699350, PMID:40366873). ERC1 also functions in NF-κB signaling by recruiting IκBα to the IKK complex and, upon genotoxic stress, undergoing XIAP/UBC13-mediated K63-ubiquitination to scaffold TAK1 activation—a pathway exploited by dengue virus NS5, which degrades ERC1 to suppress innate immune responses (PMID:15218148, PMID:20932476, PMID:37252973).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1999 Medium

    Identification of ERC1 as a coiled-coil protein capable of dimerization established the structural basis for its scaffolding function and explained how ELKS-RET fusions constitutively activate RET kinase in papillary thyroid carcinoma.

    Evidence cDNA cloning and in vitro chimeric protein autophosphorylation assays

    PMID:10337992 PMID:12203787

    Open questions at the time
    • No endogenous signaling function yet assigned
    • In vitro only — no cellular transformation assay
  2. 2004 High

    Two parallel discoveries revealed ERC1's dual cellular roles: as an essential NF-κB scaffold that recruits IκBα to IKK, and as a presynaptic active zone component that binds RIM1 and localizes to the cytomatrix.

    Evidence siRNA knockdown with NF-κB reporters/apoptosis assays (human cells); co-IP, yeast two-hybrid, immunoelectron microscopy (rat brain)

    PMID:14723704 PMID:15218148

    Open questions at the time
    • Mechanism by which ERC1 recruits IκBα not molecularly defined
    • Whether NF-κB and synaptic functions are isoform-specific
  3. 2005 High

    Genetic studies in C. elegans and functional studies in β-cells established ERC1 as a conserved organizer of exocytic machinery, directly interacting with RIM at active zones and promoting insulin granule docking and fusion.

    Evidence C. elegans elks-1 loss-of-function genetics plus yeast two-hybrid; TIRF/immunoEM in β-cells with siRNA and dominant-negative constructs

    PMID:15888548 PMID:15976086

    Open questions at the time
    • Precise contribution of individual ERC1 binding interfaces to exocytosis not resolved
    • Redundancy between ELKS1 and ELKS2 not yet addressed
  4. 2006 High

    Placing ERC1 downstream of liprin-α (SYD-2) in active zone assembly, and mapping its separable RIM2- and Bassoon-binding domains, defined ERC1 as a modular scaffold linking active zone organizers to the release machinery.

    Evidence Genetic epistasis in C. elegans (syd-2 gain-of-function suppressed by elks-1 loss); structure-function deletion analysis with hGH secretion assays in PC12 cells

    PMID:16716196 PMID:17115037

    Open questions at the time
    • Stoichiometry and architecture of the multi-protein complex unknown
    • Mammalian in vivo validation of liprin–ELKS hierarchy not yet done
  5. 2010 High

    The discovery that genotoxic stress induces ATM/NEMO-dependent K63-ubiquitination of ERC1 by XIAP/UBC13, enabling TAK1 recruitment via TAB2/3, revealed a distinct DNA-damage-to-NF-κB signaling axis mediated by ERC1.

    Evidence Ubiquitination assays, siRNA, NEMO ubiquitin-binding mutants, NF-κB reporter assays in human cells

    PMID:20932476

    Open questions at the time
    • Specific lysine residues on ERC1 targeted for K63-ubiquitination not identified
    • Whether this pathway operates in primary cells in vivo
  6. 2014 High

    Two studies established ERC1 as a regulator of both presynaptic release probability and cell migration: conditional double KO in hippocampal inhibitory neurons showed ~50% reduction in release with decreased Ca²⁺ influx, while ERC1 depletion in tumor cells impaired leading-edge polarity, active integrin β1 internalization, and invasion.

    Evidence Conditional ELKS1/2 double-KO mice with electrophysiology and Ca²⁺ imaging; siRNA in tumor cells with live-cell imaging and invasion assays

    PMID:24982445 PMID:25209271

    Open questions at the time
    • Whether ERC1 directly couples Ca²⁺ channels or acts indirectly through active zone architecture
    • Mechanism linking ERC1 to integrin endocytic machinery not identified
  7. 2016 Medium

    ERC1 and liprin-α1 were shown to colocalize with active integrin β1 at the cell edge and to promote peripheral Rab7-positive endosome positioning, linking ERC1's scaffolding role to endosomal trafficking and focal adhesion turnover.

    Evidence siRNA depletion, live-cell imaging, endosome localization assays in migrating cells

    PMID:27659488

    Open questions at the time
    • Direct interaction between ERC1 and endosomal machinery not demonstrated
    • SDCCAG8 interaction (PMID:27224062) lacks functional follow-up for ERC1
  8. 2018 High

    Conditional KO at the calyx of Held revealed that CAST/ELKS controls CaV2.1 channel density and number at active zones but paradoxically suppresses release probability, indicating that ERC1 restrains release efficiency even as it maintains the Ca²⁺ channel complement.

    Evidence Conditional KO mice, patch-clamp electrophysiology, CaV2.1 immunostaining, electron microscopy

    PMID:29996090

    Open questions at the time
    • Molecular mechanism by which ELKS suppresses release probability despite maintaining channels is unresolved
    • Synapse-type-specific differences (calyx vs. hippocampal) not reconciled
  9. 2019 High

    Two breakthroughs established the biophysical and structural basis for ERC1 function: ERC1 forms liquid-phase condensates via an intrinsically disordered region that recruits motility partners, and ERC1 directly binds the VDCC-β GK domain to polarize Ca²⁺ influx and insulin secretion in β-cells.

    Evidence EM/FRAP/droplet assays for phase separation; conditional β-cell KO with patch-clamp, Ca²⁺ imaging, and GST pulldown for VDCC-β interaction

    PMID:30699350 PMID:31537859

    Open questions at the time
    • Post-translational regulation of phase separation not characterized
    • Structural basis of ELKS–VDCC-β interaction not resolved
  10. 2020 High

    Forebrain-specific CAST/ELKS double deletion causing neonatal lethality, with enlarged active zones but altered CaV2 channel levels, established ERC1 as a positive regulator of presynaptic terminal size and essential for viability.

    Evidence Conditional double KO mice, confocal and electron microscopy, electrophysiology

    PMID:32304329

    Open questions at the time
    • Relative contributions of ELKS1 vs ELKS2 to terminal size regulation not separated
    • Mechanism of active zone size control unknown
  11. 2021 High

    Structural and biochemical reconstitution showed that oligomerized liprin-α2 enhances ELKS N-terminal phase separation through multivalent interactions and competitively regulates the distribution of ELKS versus RIM/RIM-BP in condensates, providing a mechanism for active zone protein compartmentalization.

    Evidence Crystal/solution structures of coiled-coil complexes, in vitro LLPS reconstitution, mutagenesis

    PMID:33761347

    Open questions at the time
    • In vivo validation of competitive partitioning model not performed
    • How liprin-α1 vs liprin-α2 differentially regulate ELKS condensates is unclear
  12. 2023 High

    Multiple studies in 2023 resolved key structural and functional interfaces: the ELKS1–Rab6B helical-hairpin crystal structure showed how LLPS concentrates Rab6B vesicles for exocytosis; the ERC1–LL5β interaction was mapped to disordered regions essential for cell-edge targeting and invasion; Drosophila studies showed ELKS–CaV2 α1 interaction is required for homeostatic Ca²⁺ channel accumulation; and dengue NS5 was found to degrade ERC1 to antagonize NF-κB signaling.

    Evidence Crystal structure plus liposome/exocytosis assays; NMR/Co-IP/invasion assays; intravital single-molecule imaging in Drosophila; proteomics/chimeric virus/NF-κB reporter assays

    PMID:36800417 PMID:37172719 PMID:37252973 PMID:37437062

    Open questions at the time
    • Whether Rab6B condensate recruitment operates at synaptic active zones in addition to secretory sites
    • Structural basis of ERC1–VDCC α1 interaction awaits atomic resolution
    • Whether NS5-mediated ERC1 degradation occurs via proteasomal or autophagic pathway
  13. 2025 Medium

    The N-terminal IDR of ERC1 (residues 1–244) was shown to be both necessary and sufficient for phase separation and required for tumor cell motility independent of partner protein binding; separately, insulin secretion was found to occur at the margins of ELKS/LL5β patches devoid of microtubules, integrating ERC1 condensate architecture with secretory function.

    Evidence In vitro LLPS/FRAP/Co-IP/motility assays for IDR function; TIRF microscopy of granule fusion in intact mouse islets

    PMID:40366873 PMID:40646182

    Open questions at the time
    • How IDR-driven phase separation is regulated by phosphorylation or other modifications remains unknown
    • Mechanism linking microtubule exclusion to secretion at ELKS patch margins not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major open questions include: (1) how ERC1 phase separation is post-translationally regulated in different cellular contexts; (2) the atomic-resolution architecture of the multi-protein active zone complex containing ERC1; (3) isoform-specific functions of ERC1 splice variants in NF-κB versus synaptic/migratory roles; and (4) whether ERC1's NF-κB and cytoskeletal functions are coordinated or fully independent.
  • No structural model of ERC1 in complex with RIM, Bassoon, and VDCC subunits simultaneously
  • Isoform-specific knockout studies not performed
  • Post-translational regulation of IDR-driven condensation uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 4 GO:0060090 molecular adaptor activity 4
Localization
GO:0005886 plasma membrane 4 GO:0005829 cytosol 2 GO:0031410 cytoplasmic vesicle 2
Pathway
R-HSA-112316 Neuronal System 6 R-HSA-1500931 Cell-Cell communication 3 R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 3 R-HSA-382551 Transport of small molecules 3
Partners
BSNCACNBPHLDB2PPFIA1PPFIA2RAB6BRIM1RIM2
Complex memberships
ERC1–liprin-α–LL5β leading-edge complexIKK complexpresynaptic active zone cytomatrix

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 ELKS (ERC1) encodes a protein with multiple coiled-coil domains that can form dimers; fusion of the 5' dimerization domains of ELKS to the RET tyrosine kinase domain constitutively activates RET kinase in papillary thyroid carcinoma. cDNA cloning, in vitro synthesis of chimeric proteins, immunoblotting with anti-phosphotyrosine antibodies Genes, chromosomes & cancer Medium 10337992
2002 ELKS is alternatively spliced into at least five isoforms (α–ε); all ELKS-RET chimeric fusion proteins retaining the oligomerization (coiled-coil) domains of ELKS are constitutively autophosphorylated at tyrosine residues, confirming dimerization-driven RET kinase activation. RT-PCR isoform characterization, in vitro synthesis of fusion proteins, immunoblotting with anti-phosphotyrosine antibodies Genes, chromosomes & cancer Medium 12203787
2004 ELKS (ERC1) is an essential regulatory subunit of the IKK complex; it recruits IκBα to the IKK complex, and siRNA-mediated silencing of ELKS blocks NF-κB target gene expression and impairs protection from cytokine-induced apoptosis. siRNA knockdown, co-immunoprecipitation, mass spectrometry interactome, NF-κB reporter assays, apoptosis assays Science High 15218148
2004 CAST2 (rat orthologue of human ELKS/ERC1) directly binds RIM1 via its C-terminus and forms a hetero-oligomer with CAST1; both localize to the presynaptic active zone cytomatrix. Subcellular fractionation, co-immunoprecipitation, immunoelectron microscopy, yeast two-hybrid Genes to cells High 14723704
2005 In C. elegans, ELKS-1 is an active zone protein that directly interacts with the PDZ domain of RIM (UNC-10); redundant protein–protein interactions anchor both ELKS and RIM to active zones; RIM truncations containing PDZ and C2A domains require ELKS for active zone targeting. Genetic loss-of-function (elks mutants), in vivo imaging, yeast two-hybrid, behavioral and electrophysiological assays The Journal of neuroscience High 15976086
2005 ELKS (ERC1) localizes near insulin granules docked at the plasma membrane in pancreatic β-cells; introduction of the Bassoon-binding region of ELKS reduces insulin granule docking and fusion; siRNA knockdown of ELKS reduces glucose-evoked insulin release. Confocal and immunoelectron microscopy, TIRF microscopy, dominant-negative overexpression, siRNA knockdown, insulin secretion assay Molecular biology of the cell High 15888548
2006 ELKS promotes Ca2+-dependent exocytosis in PC12 cells via direct binding to RIM2 (through its C-terminal IWA motif) and to Bassoon (through a central region); this function requires the RIM2–Munc13-1 pathway. Overexpression of full-length and deletion constructs, hGH secretion assay, dominant-negative interference with Munc13-1 binding domain Genes to cells High 16716196
2006 In C. elegans, a gain-of-function mutation in SYD-2 (Liprin-α) promotes presynaptic active zone assembly in an ELKS-1-dependent manner; mutant SYD-2 shows increased association with ELKS, placing ELKS downstream of SYD-2 in active zone assembly. Genetic epistasis (elks-1 loss-of-function suppresses syd-2 gain-of-function), co-immunoprecipitation Nature neuroscience High 17115037
2010 ATM- and NEMO-dependent K63-linked polyubiquitination of ELKS (mediated by ubiquitin ligase XIAP and conjugating enzyme UBC13) allows ELKS to associate with TAK1 via ubiquitin-binding subunits TAB2/3, leading to IKK and NF-κB activation in response to genotoxic stress. Co-immunoprecipitation, ubiquitination assays, siRNA knockdown, NEMO ubiquitin-binding mutants, NF-κB reporter assays Molecular cell High 20932476
2014 ERC1a (isoform of ERC1), together with liprin-α1 and LL5α/β, forms a polarized complex at the protruding cell front that is required for cell migration and tumor invasion; depletion of ERC1 impairs lamellipodial persistence and internalization of active integrin β1. siRNA depletion, live-cell imaging, invasion assays, co-immunoprecipitation, integrin internalization assays Journal of cell science High 24982445
2014 Removal of both ELKS1 and ELKS2 in hippocampal inhibitory neurons reduces neurotransmitter release by ~50% with decreased release probability, and causes ~30% reduction in action potential-triggered Ca2+ influx at inhibitory nerve terminals without reducing presynaptic Ca2+ channel levels. Conditional double knockout mice, electrophysiology, Ca2+ imaging, electron microscopy The Journal of neuroscience High 25209271
2016 Liprin-α1 and ERC1 colocalize with active integrin β1 at the cell edge distinct from focal adhesion markers, and promote the localization of peripheral Rab7-positive endosomes; ERC1 localization at the cell edge is required for disassembly of focal adhesions. siRNA depletion, live-cell imaging, co-immunoprecipitation, endosome localization assays, dominant-negative liprin-N expression Scientific reports Medium 27659488
2016 SDCCAG8 interacts with ERC1 as part of an endosomal sorting complex at the centrosome, identified by affinity proteomics. Affinity proteomics (AP-MS), co-immunoprecipitation PloS one Low 27224062
2018 Deletion of CAST/ELKS at the calyx of Held reduces CaV2.1 channel density and numbers; paradoxically increases release probability while decreasing the readily releasable pool; also elevates spontaneous release rates; Ca2+ channel coupling is unchanged. Conditional knockout mice, patch-clamp electrophysiology, electron microscopy, immunostaining for CaV2.1 clusters Cell reports High 29996090
2019 ERC1 exists as an extended flexible dimer; ERC1 scaffolds form cytoplasmic condensates with liquid-phase behavior modulated by a predicted intrinsically disordered region; these condensates recruit liprin-α1 and other cell motility partners. Electron microscopy, single-molecule analysis, FRAP, live-cell imaging, droplet assays Scientific reports Medium 31537859
2019 ELKS directly interacts with the GK domain of the VDCC-β subunit; β-cell-specific ELKS knockout impairs L-type VDCC current density, reduces polarized Ca2+ influx at the vascular-facing plasma membrane, and impairs first-phase glucose-stimulated insulin secretion. Conditional KO mice, patch-clamp, in situ Ca2+ imaging (G-CaMP8b), co-immunoprecipitation/GST pulldown for direct interaction Cell reports High 30699350
2020 Combined deletion of CAST/ELKS in the forebrain causes neonatal lethality; CAST/ELKS are positive regulators of presynaptic terminal size and suppressors of active zone expansion, and regulate all CaV2 subtype channel levels at the calyx of Held. Conditional KO mice, confocal morphological analysis, patch-clamp, electron microscopy The Journal of physiology High 32304329
2021 Oligomerized liprin-α2, through multivalent interactions with ELKS proteins, enhances phase separation of the ELKS N-terminal segment; liprin-α2 regulates the competitive distribution of ELKS and RIM/RIM-BP in condensates to control active zone protein compartmentalization. Structural characterization (coiled-coil crystal/solution structures), in vitro phase separation assays, biochemical binding assays, mutagenesis Cell reports High 33761347
2023 Dengue virus NS5 protein binds and degrades ERC1 via a mechanism involving the methyltransferase domain of NS5 (serotype-specific), leading to antagonism of NF-κB activation, reduced proinflammatory cytokine secretion, and reduced cell migration. Proteomics, co-immunoprecipitation, recombinant chimeric virus construction, NF-κB reporter assays, cytokine secretion assays, migration assays Proceedings of the National Academy of Sciences High 37252973
2023 A C-terminal segment of ELKS1 forms a helical hairpin to bind Rab6B through a unique mode; liquid-liquid phase separation of ELKS1 enhances competitive binding to Rab6B, accumulates Rab6B-coated liposomes into ELKS1 condensates, and promotes vesicle exocytosis at releasing sites. Crystal structure of ELKS1-Rab6B complex, in vitro LLPS assays, liposome binding assays, live-cell vesicle exocytosis assays The Journal of biological chemistry High 37172719
2023 ERC1 minimal interaction regions with LL5β are ERC1(270-370) and LL5β(381-510); the ERC1–LL5β interaction involves intrinsically disordered regions and is high-affinity; disrupting this interaction by expression of LL5β(381-510) delocalizes ERC1 from the cell edge and impairs tumor cell invasion. Co-immunoprecipitation, NMR spectroscopy, dominant-negative expression, invasion/motility assays PloS one Medium 37437062
2023 At Drosophila active zones undergoing homeostatic potentiation, ELKS/Bruchpilot distribution compacts and its interaction with the CaV2 α1-subunit Cacophony (via Cac C-terminus and ELKS amino-terminal region) is required for increased Cac numbers and sustained potentiation. Intravital single-molecule imaging of endogenously tagged proteins, genetic mutant analysis, FRAP Science advances High 36800417
2025 The N-terminal region ERC1(1-244) containing an intrinsically disordered region is sufficient to drive phase separation in vitro and in cells; deletion of this region alters the biophysical properties of ERC1 condensates and impairs tumor cell motility without disrupting partner interactions. In vitro phase separation assays, FRAP, co-immunoprecipitation, cell motility assays Communications biology Medium 40646182
2025 Insulin secretion from pancreatic β-cells is restricted to sites at the margins of ELKS/LL5β patches that are devoid of microtubules; MT disassembly and optimal ELKS content together predict secretion hot spots. TIRF microscopy of intact mouse islets, live imaging of granule fusion events relative to ELKS patch architecture and MT organization Molecular biology of the cell Medium 40366873

Source papers

Stage 0 corpus · 52 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. Neuron 728 16543132
1998 A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. Cell 263 9778250
2004 Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit. Science (New York, N.Y.) 180 15218148
2006 SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS. Nature neuroscience 177 17115037
2010 ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. Molecular cell 170 20932476
1999 Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma. Genes, chromosomes & cancer 106 10337992
2005 ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy. Molecular biology of the cell 91 15888548
2011 ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot. Neuron 83 22153374
2004 CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST. Genes to cells : devoted to molecular & cellular mechanisms 71 14723704
2014 Liprin-α1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration. Journal of cell science 66 24982445
2010 CAST and ELKS proteins: structural and functional determinants of the presynaptic active zone. Journal of biochemistry 64 20581014
2014 The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 61 25209271
2018 CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse. Cell reports 57 29996090
2012 12p13.33 microdeletion including ELKS/ERC1, a new locus associated with childhood apraxia of speech. European journal of human genetics : EJHG 57 22713806
2005 Redundant localization mechanisms of RIM and ELKS in Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience 56 15976086
2016 Liprin-α1 and ERC1 control cell edge dynamics by promoting focal adhesion turnover. Scientific reports 41 27659488
2021 Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell reports 39 33761347
2018 ELKS active zone proteins as multitasking scaffolds for secretion. Open biology 38 29491150
2019 The ERC1 scaffold protein implicated in cell motility drives the assembly of a liquid phase. Scientific reports 33 31537859
2023 Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca2+ channels drives sustained active zone potentiation. Science advances 32 36800417
2006 ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+-dependent exocytosis from PC12 cells. Genes to cells : devoted to molecular & cellular mechanisms 31 16716196
2019 ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells. Cell reports 29 30699350
2002 Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma. Genes, chromosomes & cancer 24 12203787
2016 SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling. PloS one 23 27224062
2005 Low prevalence of RET rearrangements (RET/PTC1, RET/PTC2, RET/PTC3, and ELKS-RET) in sporadic papillary thyroid carcinomas in Taiwan Chinese. Thyroid : official journal of the American Thyroid Association 23 15876154
2020 Presynaptic development is controlled by the core active zone proteins CAST/ELKS. The Journal of physiology 22 32304329
2023 Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation. Proceedings of the National Academy of Sciences of the United States of America 21 37252973
2019 Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells. Molecular metabolism 19 31500835
2018 Association of CAST2, HSP90AA1, DNAJA1 and HSPB1 genes with meat tenderness in Nellore cattle. Meat science 18 29331838
2016 Sake yeast YHR032W/ERC1 haplotype contributes to high S-adenosylmethionine accumulation in sake yeast strains. Journal of bioscience and bioengineering 14 27567046
2009 Involvement of ELKS, an active zone protein, in exocytotic release from RBL-2H3 cells. Cellular immunology 14 19515363
2007 Localization of the active zone proteins CAST, ELKS, and Piccolo at neuromuscular junctions. Neuroreport 13 17435594
2023 Structural basis of ELKS/Rab6B interaction and its role in vesicle capturing enhanced by liquid-liquid phase separation. The Journal of biological chemistry 11 37172719
2005 Hepatitis C virus NS3 protein interacts with ELKS-{delta} and ELKS-{alpha}, members of a novel protein family involved in intracellular transport and secretory pathways. The Journal of general virology 11 16033967
1986 Papillomavirus DNA associated with pulmonary fibromatosis in European elks. Journal of virology 11 3005617
2021 Circular RNA circ_0084927 regulates proliferation, apoptosis, and invasion of breast cancer cells via miR-142-3p/ERC1 pathway. American journal of translational research 10 34150003
2017 Drosophila Syd-1 Has RhoGAP Activity That Is Required for Presynaptic Clustering of Bruchpilot/ELKS but Not Neurexin-1. Genetics 10 29217522
2000 Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma. Journal of human genetics 9 10697956
2022 FGFR2-ERC1: A Subtype of FGFR2 Oncogenic Fusion Variant in Lung Adenocarcinoma and the Response to Anlotinib. OncoTargets and therapy 8 35712652
2013 Antibodies to active zone protein ERC1 in Lambert-Eaton myasthenic syndrome. Human immunology 8 23583364
2021 Case report: identification of ERC1-RET fusion in a patient with pancreatic ductal adenocarcinoma. Gland surgery 6 34733735
2020 Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data. Neurobiology of aging 6 32768867
2025 Directed insulin secretion from beta cells occurs at cortical sites devoid of microtubules at the edges of ELKS/LL5β patches. Molecular biology of the cell 4 40366873
2024 Biomolecular condensation of ERC1 recruits ATG8 and NBR1 to drive autophagosome formation for plant heat tolerance. bioRxiv : the preprint server for biology 2 39314317
2023 Interfering with the ERC1-LL5β interaction disrupts plasma membrane-Associated platforms and affects tumor cell motility. PloS one 2 37437062
2020 The sake yeast YHR032W/ERC1 allele contributes to the regulation of the tetrahydrofolate content in the folate synthetic pathway in sake yeast strains. Bioscience, biotechnology, and biochemistry 2 31961264
2025 Directed insulin secretion from beta cells occurs at cortical sites devoid of microtubules at the edges of ELKS/LL5β patches. bioRxiv : the preprint server for biology 1 39553950
2025 Altering the biophysical properties of ERC1/ELKS-driven condensates interferes with cell motility. Communications biology 1 40646182
2025 Biomolecular condensation of ERC1 recruits ATG8 and NBR1 to drive autophagosome formation for plant heat tolerance. Proceedings of the National Academy of Sciences of the United States of America 0 41213015
2025 CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge. Journal of cell science 0 41277545
2023 Successful Crizotinib-targeted Therapy of Pediatric Unresectable ERC1::ALK Fusion Sarcoma. Journal of pediatric hematology/oncology 0 38099690
2020 Double deletion of the active zone proteins CAST/ELKS in the mouse forebrain causes high mortality of newborn pups. Molecular brain 0 31996256