Affinage

ELMO1

Engulfment and cell motility protein 1 · UniProt Q92556

Length
727 aa
Mass
83.8 kDa
Annotated
2026-06-09
100 papers in source corpus 41 papers cited in narrative 41 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ELMO1 is an evolutionarily conserved cytoplasmic adaptor that serves as the regulatory subunit of a bipartite Rac guanine nucleotide exchange factor, partnering with DOCK1/2/5 proteins to drive actin-dependent processes including cell migration, apoptotic-cell engulfment, and phagocytosis (PMID:14638695, PMID:20844538). ELMO1 binds DOCK proteins through two interfaces — its C-terminal PH domain engaging the DOCK N-terminus and its C-terminal proline-rich tail winding around the DOCK SH3 domain — and this association is required for DOCK-mediated Rac activation and actin polymerization (PMID:12829596, PMID:18768751, PMID:22331897). Structural studies established that the binary ELMO1–DOCK complex rests in a closed, mutually autoinhibited conformation, and that upstream cues drive a closed-to-open transition exposing the DHR2 Rac1-binding surface; the ELMO1 PH domain further contacts nucleotide-free RAC1 to potentiate DOCK GEF activity (PMID:22331897, PMID:32651375, PMID:34290093, PMID:38857861). Autoinhibition is relieved by multiple inputs: small-GTPase RhoG binding, tyrosine phosphorylation by Src-family kinases (notably at Y511 and Y724, which recruits Nck-1 and is required for Rac activation, spreading, and migration), Gβγ or Gαi2 binding to the ELMO1 N-terminus downstream of chemokine GPCRs, the FE65/ARF6 trafficking module, and acidic-lipid-driven conformational change at the membrane (PMID:15952790, PMID:26205662, PMID:27313788, PMID:23591873, PMID:29615491, PMID:33047393, PMID:41233496). ELMO1 additionally stabilizes DOCK protein levels by blocking their ubiquitin-proteasomal degradation (PMID:16495483, PMID:24821968). Genetically, ELMO1 acts downstream of engulfment receptors such as BAI1 and morphogenic cues including Netrin-1/Unc5B and RhoG to control Sertoli-cell clearance of apoptotic germ cells, vascular morphogenesis, neuronal spine and neurite formation, and Schwann-cell myelination (PMID:20844538, PMID:20466982, PMID:21900250, PMID:29615491, PMID:31161284). Beyond its canonical GEF role, ELMO1 functions in innate immunity and inflammatory disease: it governs Salmonella internalization and LC3-associated phagocytosis, interacts with Med31 and NOD2 to shape cytokine output and bacterial clearance, regulates neutrophil recruitment and osteoclast bone resorption, and engages a Rac1-independent COX-2 pathway and SIRT1/DRP1 metabolic axes (PMID:26878033, PMID:29029244, PMID:23273896, PMID:36694274, PMID:30643265, PMID:34404802, PMID:20732417, PMID:38756351, PMID:41250600).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2003 High

    Established the foundational mechanism: ELMO1 is not a standalone enzyme but the regulatory half of a bipartite Rac GEF, with DOCK supplying catalysis and ELMO1 supplying spatial control.

    Evidence Transwell migration with deletion mutants and C. elegans CED-5 rescue; Co-IP and Rac-activation rescue in T cells

    PMID:12829596 PMID:14638695

    Open questions at the time
    • Did not resolve the structural basis of the ELMO1-DOCK interface
    • Did not define how upstream signals engage the complex
  2. 2005 High

    Identified tyrosine phosphorylation as an activating input: Src-family kinase Hck binds and phosphorylates ELMO1 at multiple tyrosines, with Y511 required for efficient Rac activation, phagocytosis, and migration.

    Evidence GST pulldown, in-cell co-IP, MS site mapping, and phospho-site mutants with phagocytosis/migration readouts

    PMID:12029088 PMID:15952790

    Open questions at the time
    • Did not show how phosphorylation alters complex conformation
    • Did not identify phospho-tyrosine reader proteins
  3. 2006 Medium

    Revealed a second, non-catalytic ELMO1 function — protecting DOCK from degradation — establishing ELMO1 as a stabilizer of its own partner.

    Evidence In vivo ubiquitylation assay with proteasome-inhibitor rescue and ELMO1 mutants

    PMID:16495483

    Open questions at the time
    • E3 ligase acting on DOCK not identified
    • Single lab; not extended to all DOCK paralogs at the time
  4. 2008 High

    Defined the molecular ELMO1-DOCK interface: the ELMO1 PH domain (FERM-like, non-lipid-binding) and proline-rich tail form a dual-interface contact, requiring disruption of both to break the complex.

    Evidence Crystal structure of ELMO1 PH domain with point mutagenesis and cellular Rac signaling assays

    PMID:18768751

    Open questions at the time
    • Did not capture the full-length autoinhibited complex
    • Did not show the active Rac-bound state
  5. 2010 High

    Placed ELMO1 in an ordered in vivo engulfment pathway and a morphogenic signaling axis, demonstrating physiological roles beyond cultured cells.

    Evidence ELMO1 KO mouse with BAI1/RAC1 genetic epistasis; zebrafish elmo1 knockdown downstream of Netrin-1/Unc5B

    PMID:20466982 PMID:20844538

    Open questions at the time
    • Did not address receptor-to-ELMO1 coupling mechanism
    • Netrin pathway evidence is morpholino-based, single lab
  6. 2012 High

    Resolved the mutual-autoinhibition logic of the complex structurally: DOCK and ELMO1 each suppress the other's autoinhibitory contacts, so binding primes the complex for activation.

    Evidence 2.1-Å crystal structure of DOCK2-ELMO1 with mutagenesis and binding assays

    PMID:22331897

    Open questions at the time
    • Did not visualize the open active state or Rac1 engagement
    • Did not show how upstream effectors trigger opening
  7. 2013 High

    Connected GPCR/heterotrimeric-G-protein signaling to the complex: Gαi2 drives ELMO1 membrane translocation and Rac activation downstream of chemokine receptors, linking the module to cancer cell migration.

    Evidence Reciprocal Co-IP, membrane fractionation, Rac assay, and in vivo metastasis knockdown

    PMID:23591873

    Open questions at the time
    • Did not define the Gαi2-binding interface at residue level
    • Relationship to Gβγ binding not yet integrated
  8. 2014 High

    Demonstrated paralog-specific, physiologically relevant DOCK stabilization: endogenous ELMO1, not ELMO2, maintains DOCK2 levels in primary T cells and supports chemokine-driven chemotaxis.

    Evidence Co-IP from primary T cells, Elmo1 KO mouse, ubiquitination assay, proteasome rescue, and chemotaxis

    PMID:24821968 PMID:24928514

    Open questions at the time
    • DOCK2 E3 ligase still unidentified
    • Nck-1/phospho-ELMO1 link based on pulldown and mutants in single lab
  9. 2015 High

    Expanded the activator repertoire and downstream output: Src phosphorylation at Y724 is essential for Rac-driven adhesion/migration, and ELMO1/DOCK signaling protects endothelial cells via Rac1/PAK/AKT.

    Evidence In vitro/in vivo phosphorylation with Y724F mutant and spreading assays; apoptosis assays plus zebrafish vessel formation; macrophage Salmonella internalization with KO mouse

    PMID:25586182 PMID:26205662 PMID:26878033

    Open questions at the time
    • Anti-apoptotic and bacterial-internalization roles characterized in single labs
    • Mechanistic crosstalk between these branches unresolved
  10. 2017 Medium

    Identified non-canonical and regulatory branches: ELMO1 governs LC3-associated phagocytosis, is transcriptionally repressed by TGFβ in cancer stem cells, and competes for Ephexin4 to activate RhoG.

    Evidence siRNA/imaging with ATG5/ULK1 epistasis; Tgfbr2 KO carcinoma model; co-IP domain mapping with competition and engulfment assays

    PMID:28219480 PMID:28667327 PMID:29029244

    Open questions at the time
    • LC3-phagocytosis molecular link to LC3 machinery incomplete
    • Each branch from a single lab
  11. 2020 High

    Visualized the activation cycle: cryo-EM captured closed autoinhibited and open Rac1-loaded states, showing how relief of autoinhibition exposes Rac1- and RhoG/BAI-binding surfaces.

    Evidence Cryo-EM of DOCK2-ELMO1 alone and with RAC1, RhoG-ELMO2-RBD crystal structure, and interface mutagenesis

    PMID:32651375

    Open questions at the time
    • Did not capture membrane-bound active complex
    • Did not reconstitute all phospho/acetyl inputs structurally
  12. 2021 High

    Defined the catalytic contribution of the ELMO1 PH domain and broadened tissue roles: the PH domain directly contacts nucleotide-free RAC1 to enhance DOCK5 GEF activity, and ELMO1 is a druggable osteoclast signaling hub.

    Evidence 3.8-Å cryo-EM of ELMO1-DOCK5-RAC1 with GEF assays; Elmo1 KO in four bone-loss models with proteomic interactome and inhibitory peptide; m6A regulation of ELMO1 in MSCs

    PMID:34290093 PMID:34404802 PMID:34508078

    Open questions at the time
    • Osteoclast interactome partners (cathepsin G, MPO) mechanistically unintegrated with GEF role
    • m6A regulation single lab, Medium confidence
  13. 2024 High

    Integrated RhoG-driven activation and membrane/lipid control, and added post-translational and metabolic regulatory layers governing the activation switch and disease outputs.

    Evidence Cryo-EM of DOCK5/ELMO1±RhoG/Rac1 with SPR and GEF assays; K505 acetylation by P300/SIRT2 with Rac readout; ELMO1-SIRT1-p65 senescence axis in colitis KO mice

    PMID:38750717 PMID:38756351 PMID:38857861

    Open questions at the time
    • How RhoG, phosphorylation, and acetylation inputs are combinatorially integrated unknown
    • Acetylation and senescence branches from single labs, Medium confidence
  14. 2025 High

    Showed that the plasma membrane lipid environment is itself an activating input, with acidic lipids driving a hinge rotation that tunes GEF activity, and extended ELMO1 into mitochondrial metabolic control during infection.

    Evidence Cryo-EM on lipid-coated grids with GEF assays and cellular signaling; TMT proteomics and Seahorse with ELMO1 KO macrophages linking ELMO1-DRP1 to TNF-α

    PMID:41233496 PMID:41250600

    Open questions at the time
    • Metabolic/DRP1 branch mechanism Medium confidence, single lab
    • How lipid-, GTPase-, and PTM-driven conformational changes are coordinated on native membranes unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown how the diverse activating inputs (RhoG, Gβγ/Gαi2, tyrosine phosphorylation, K505 acetylation, FE65/ARF6 trafficking, acidic lipids) are quantitatively integrated to set GEF output in a given cell type, and which E3 ligase ELMO1 antagonizes to stabilize DOCK proteins.
  • No unified model linking PTMs, GTPase binding, and lipid sensing to graded activation
  • DOCK-targeting E3 ligase unidentified
  • Rac1-independent COX-2 and metabolic branches not mechanistically reconciled with the GEF function

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0098772 molecular function regulator activity 4 GO:0005198 structural molecule activity 2
Localization
GO:0005886 plasma membrane 6 GO:0005829 cytosol 3 GO:0031410 cytoplasmic vesicle 2
Pathway
R-HSA-168256 Immune System 5 R-HSA-162582 Signal Transduction 4 R-HSA-1266738 Developmental Biology 3 R-HSA-5357801 Programmed Cell Death 3
Partners
DOCK1DOCK2DOCK5FE65GNAI2HCKRAC1RHOG
Complex memberships
DOCK2-ELMO1 complexDOCK5-ELMO1 complexELMO1-DOCK180/DOCK1 bipartite Rac GEFFE65-ELMO1-DOCK180 tripartite complex

Evidence

Reading pass · 41 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 ELMO1 forms a complex with DOCK180 to function as a bipartite guanine nucleotide exchange factor (GEF) for Rac1, promoting cell migration; the N-terminal 330 amino acids of ELMO1 are required for localization to lamellipodia and migration but not for Rac activation per se, indicating that spatial control of Rac activation is critical. Transwell migration assay with ELMO1/DOCK180 deletion mutants; C. elegans transgenic rescue of CED-5 mutant The Journal of biological chemistry High 14638695
2003 DOCK2 associates with ELMO1 through its SH3 domain; this association is required for DOCK2-mediated Rac activation and actin polymerization in T cells — a DOCK2 mutant lacking the ELMO1-binding region fails to activate Rac. Co-immunoprecipitation; expression of DOCK2 mutant lacking ELMO1-binding region in T-hybridoma cells; Rac activation assay Blood High 12829596
2002 ELMO1 directly binds the SH3 domain of the Src-family kinase Hck via a polyproline motif, and is heavily tyrosine-phosphorylated in cells co-expressing Hck, identifying ELMO1 as a substrate of Hck. GST pulldown with purified proteins; co-immunoprecipitation in intact cells; mass spectrometry identification; phosphorylation detected by immunoblot The Journal of biological chemistry Medium 12029088
2005 Hck phosphorylates ELMO1 at Tyr18, Tyr216, Tyr395, Tyr511, and Tyr720; mutants lacking these sites are defective in promoting phagocytosis and migration, with Tyr511 being particularly important; these mutants retain Dock180 and Crk binding but show reduced Rac activation. Mass spectrometry identification of phosphorylation sites; site-directed mutagenesis; phagocytosis and migration assays; Rac activation assay Biochemistry High 15952790
2005 ELMO1 directly interacts with ERM proteins (e.g., radixin) via its N-terminal 280 amino acids, a region overlapping with the RhoG-binding site but distinct from the C-terminal Dock180-binding region; ELMO1 can simultaneously bind radixin and Dock180; radixin binding occurs independently of radixin C-terminal phosphorylation status. In vitro pulldown with purified recombinant proteins; co-immunoprecipitation at endogenous levels; domain-mapping with deletion mutants; co-localization at plasma membrane The Journal of biological chemistry High 16377631
2006 ELMO1 inhibits ubiquitylation of Dock180, preventing its proteasomal degradation; Dock180 is ubiquitylated on the plasma membrane, enhanced by EGF, Crk, and adhesion signals, and ELMO1 binding (via its N-terminal region encompassing aa 531+) blocks this ubiquitylation. In vivo ubiquitylation assay; proteasome inhibitor treatment; co-expression experiments; immunofluorescence showing membrane translocation of ubiquitinated Dock180 Journal of cell science Medium 16495483
2008 The C-terminal ~200 aa of ELMO1, comprising its PH domain, mediate direct interaction with the N-terminal ~200 aa of DOCK180; the ELMO1 PH domain cannot bind phospholipids but structurally resembles FERM domains; an N-terminal amphipathic alpha-helix in this PH domain is critical for DOCK180 binding (point mutants of invariant hydrophobic residues disrupt complex formation); a secondary interaction involves the DOCK180 SH3 domain and ELMO1 C-terminal proline-rich motifs; disrupting both interfaces is required to abrogate the complex. Crystal structure of ELMO1 PH domain; biochemical binding assays; point mutagenesis of hydrophobic helix residues; Rac signaling assays in cells Molecular biology of the cell High 18768751
2004 HIV-1 Nef binds the DOCK2-ELMO1 complex (purified to near homogeneity from T cells), activates Rac in T cells, and inhibits lymphocyte chemotaxis through this interaction. Proteomic purification of Nef-associated complex; mass spectrometry identification; Rac activation assay; chemotaxis assay PLoS biology High 14737186
2010 ELMO1-deficient mice display defective phagocytic clearance of apoptotic germ cells by Sertoli cells, resulting in testicular pathology; the pathway involves BAI1 (upstream receptor) → ELMO1 → DOCK1 → RAC1 (downstream), as shown by genetic epistasis in vivo. ELMO1 knockout mouse; histopathology; in vitro and in vivo engulfment assays; genetic epistasis with BAI1 and RAC1 loss-of-function Nature High 20844538
2010 ELMO1/DOCK180 acts downstream of Netrin-1/Unc5B receptor signaling to activate Rac1 in endothelial cells, regulating vascular morphogenesis in zebrafish. Morpholino knockdown of elmo1 in zebrafish; in situ hybridization; functional interaction assays with Netrin-1/Unc5B signaling components Circulation research Medium 20466982
2011 RhoG functions upstream of ELMO1/Dock180 to regulate Rac GTPase and spine morphogenesis in hippocampal neurons; depletion of Dock180 or ELMO1 inhibits spine formation, and overexpression promotes it, establishing the RhoG/ELMO1/Dock180 module in this process. RNAi screen of 70 Rho GEFs in hippocampal neurons; overexpression and knockdown of individual components; Rac activation assays The Journal of biological chemistry Medium 21900250
2012 Crystal structure of DOCK2-ELMO1 complex at 2.1-Å resolution reveals: the ELMO1 C-terminal Pro-rich tail winds around the DOCK2 SH3 domain; an intermolecular five-helix bundle forms at the interface; DOCK2 DHR2 GEF domain autoinhibits DOCK2 by associating with its ELMO-interacting region, and ELMO1 binding weakens this autoinhibitory interaction; conversely, the N- and C-terminal regions of ELMO1 mediate its own autoinhibition, and DOCK2 binding buries the ELMO1 autoinhibitory residues — thus DOCK2 and ELMO1 mutually relieve autoinhibition. Crystal structure at 2.1 Å; mutagenesis; biochemical binding assays Proceedings of the National Academy of Sciences of the United States of America High 22331897
2012 ELMO1 binds the Mediator complex subunit Med31; during Salmonella infection in macrophages, ELMO1 increases cytoplasmic localization of Med31 and enhances monoubiquitination of Med31, specifically affecting IL-10 and IL-33 gene expression. Co-immunoprecipitation; subcellular fractionation; ubiquitination assay; gene expression analysis in macrophages Current biology : CB Medium 23273896
2013 CXCL12 stimulation promotes interaction between Gαi2 and ELMO1; Gi signaling triggers Gαi2-dependent membrane translocation of ELMO1, which then associates with Dock180 to activate Rac1 and Rac2, linking GPCR/Gi signaling to actin polymerization and breast cancer cell migration. Co-immunoprecipitation; membrane fractionation; knockdown of ELMO1 and Gαi2; Rac activation assay; in vivo metastasis assay Nature communications High 23591873
2014 Endogenous ELMO1 (but not ELMO2) constitutively interacts with Dock2 in primary mouse and human T cells; Elmo1 deficiency reduces Dock2 protein levels (by ~4-fold) through increased Dock2 polyubiquitination and proteasomal degradation; Elmo1 expression in heterologous cells inhibits Dock2 ubiquitination; loss of ELMO1 impairs CCR7- and CXCR4-dependent Rac activation and T cell chemotaxis. Co-immunoprecipitation from primary T cells; Elmo1 KO mouse; proteasome inhibitor rescue; ubiquitination assay; Rac activation assay; chemotaxis assay; transfection rescue with Elmo1 mutants Journal of immunology High 24821968
2014 Arhgef16 interacts with ELMO1 in mammalian cells (identified by yeast two-hybrid and confirmed by co-IP); Arhgef16-mediated engulfment of apoptotic cells is synergistically increased by ELMO1 but abrogated in its absence; this pathway is RhoG-dependent and Dock1-independent. Yeast two-hybrid screen; co-immunoprecipitation; apoptotic cell engulfment assay; RhoG and Dock1 epistasis experiments Biochimica et biophysica acta Medium 25063526
2015 ELMO1/Dock180 protects endothelial cells from apoptosis via activation of the Rac1/PAK/AKT signaling cascade; overexpression reduces caspase-3/7 activity and annexin V staining; this anti-apoptotic effect is Rac1-dependent. Overexpression and knockdown in human endothelial cells; caspase-3/7 activity assay; annexin V staining; PAK and AKT phosphorylation assays; zebrafish embryo apoptosis and vessel formation assays The Journal of biological chemistry Medium 25586182
2015 ELMO1 is required for Salmonella internalization by macrophages via a BAI1-ELMO1-Rac1 pathway; ELMO1 depletion reduces Rac1 activation (~6-fold), impairs bacterial internalization, reduces TNF-α and MCP-1 release, and attenuates NF-κB, ERK1/2, and p38 MAP kinase activation; in vivo, ELMO1-deficient mice show 90% reduction in bacterial burden. siRNA knockdown in macrophage cell lines and intestinal macrophages; ELMO1 KO mice; Rac1 pulldown assay; cytokine array; signaling pathway (NF-κB, ERK, p38) assays Cellular and molecular gastroenterology and hepatology High 26878033
2015 Src phosphorylates ELMO1 at Tyr724 (and Tyr720); Y724F mutation abolishes Src-induced Rac1 activation, impairs cell spreading on fibronectin, and inhibits actin stress fiber/focal adhesion assembly and cell migration. In vivo and in vitro phosphorylation assays; site-directed mutagenesis (Y724F); stable cell lines; Rac1 activity assay; cell spreading/migration assays Cell communication and signaling : CCS High 26205662
2016 ELMO1 directly interacts with Gβγ subunit upon chemokine GPCR activation; the interaction is through the N-terminus of ELMO1; Gβγ-ELMO1 interaction is required for ELMO1 membrane translocation and subsequent Rac1 activation during chemotaxis. Co-immunoprecipitation showing ELMO1-Gβγ interaction; ELMO1 deletion mutants mapping N-terminal binding; membrane fractionation; Rac1 activation assay; chemotaxis assay Journal of Cancer Medium 27313788
2017 ELMO1 regulates LC3-associated phagocytosis (but not classical ULK1-dependent autophagy) during Salmonella infection; ELMO1 is present in intracellular vesicles/phagosomes and enhances LC3B accumulation via ATG5-dependent pathway; ELMO1 depletion increases phagosomal pH and decreases cathepsin B activity, impairing bacterial clearance. siRNA knockdown; immunofluorescence of ELMO1 in vesicles; LC3B accumulation assay; phagosomal pH measurement; cathepsin B activity assay; ATG5 and ULK1 epistasis The Journal of infectious diseases Medium 29029244
2017 TGFβ signaling represses ELMO1 expression; loss of TGFβ receptor II (Tgfbr2) de-represses ELMO1 specifically in cancer stem cells, promoting invasion and metastasis; restoration of Tgfbr2 completely blocks ELMO1 expression in vivo. Mouse model of Tgfbr2 KO squamous cell carcinoma; Elmo1 knockdown impairing lung metastasis; genetic rescue with Tgfbr2 restoration eLife Medium 28219480
2018 FE65 neuronal adaptor interacts with ELMO1 N-terminal region, activates ELMO1 by disrupting its intramolecular autoinhibitory interaction (between ELMO1 N-terminal EID and C-terminal EAD), promotes ELMO1 plasma membrane targeting, and thereby enhances DOCK180-mediated Rac1 activation and neurite outgrowth; FE65, ELMO1, and DOCK180 form a tripartite complex. Co-immunoprecipitation; ELMO1 autoinhibition disruption assay; plasma membrane fractionation; Rac1 activation assay; neurite outgrowth measurement; FE65 double mutant that disrupts ELMO1 binding as control The Journal of biological chemistry Medium 29615491
2019 ELMO1 associates with receptors linked to neutrophil function and regulates neutrophil activation and early recruitment to joints; Elmo1-deficient mice show reduced joint inflammation in arthritis models; human donors with ELMO1 SNP show increased neutrophil migratory capacity; ELMO1 knockdown reduces human neutrophil migration to arthritis-associated chemokines. Elmo1 KO mouse in acute and chronic arthritis models; genetic and cell-biology studies linking ELMO1 to neutrophil receptors; human neutrophil migration assays with ELMO1 knockdown Nature immunology High 30643265
2019 ELMO1 interacts with active RhoG in platelets; ELMO1 deficiency enhances platelet aggregation, granule secretion, integrin αIIbβ3 activation, thromboxane generation, and spreading specifically downstream of GPVI agonists but not PAR4; RhoG activity is enhanced in ELMO1-deficient platelets, indicating ELMO1 negatively regulates GPVI-mediated thrombus formation via RhoG. ELMO1 KO mouse; platelet aggregation, secretion, integrin activation assays; RhoG pulldown assay; ferric-chloride injury model; pulmonary embolism model Blood advances High 30787021
2019 Nck-1 SH2 domain interacts with phosphotyrosine residues (Tyr18, Tyr216, Tyr395, Tyr511) on ELMO1; this interaction augments ELMO1-RhoG binding, promotes Rac1 activation, and increases cell motility; an SH2-inactive Nck-1 mutant (R308K) or a 4YF ELMO1 mutant lacking these phosphotyrosines abolishes the interaction. GST pulldown; co-immunoprecipitation; site-directed mutagenesis; tyrosine phosphatase inhibitor and Hck co-expression; Rac1 activation assay; cell motility assay The Journal of biological chemistry Medium 24928514
2020 Cryo-EM structures of DOCK2-ELMO1 alone and as ternary complex with RAC1, plus crystal structure of RhoG-ELMO2-RBD: the binary complex adopts a closed autoinhibited conformation; relief of autoinhibition to an open state exposes RAC1-binding sites on DOCK2 DHR2 and RHOG/BAI GPCR-binding sites on ELMO1; upstream effectors including phosphorylation of DOCK2 and ELMO1 destabilize the autoinhibited state. Cryo-EM structure of DOCK2-ELMO1 alone and with RAC1; crystal structure of RHOG-ELMO2-RBD; mutagenesis validating interface residues Nature communications High 32651375
2021 Cryo-EM structure of active ELMO1-DOCK5 complex bound to RAC1 at 3.8 Å: the C-terminal PH domain of ELMO1 aids binding of DOCK5 DHR2 to nucleotide-free RAC1; an alpha-helical scaffold between ELMO1 and DOCK5 stabilizes RAC1 binding; mutagenesis confirmed that the PH domain of ELMO1 enhances GEF activity of DOCK5 through direct interactions with RAC1. Cryo-EM structure at 3.8 Å; site-directed mutagenesis; GEF activity assay Science advances High 34290093
2021 TNF-α increases ELMO1 expression in ankylosing spondylitis MSCs via METTL14-dependent m6A modification of ELMO1 3'UTR; elevated ELMO1 drives enhanced directional migration of MSCs; inhibiting ELMO1 in SKG mice has therapeutic effects in spondyloarthritis. m6A modification analysis; METTL14 knockdown/overexpression; ELMO1 expression assays; in vitro and in vivo migration assays; SKG mouse model with ELMO1 inhibition Nature communications Medium 34508078
2021 ELMO1 is a signaling hub in osteoclasts required for bone resorption; ELMO1 deletion reduces bone loss in four in vivo models (osteoprotegerin deficiency, ovariectomy, two inflammatory arthritis types); ELMO1 interactome in osteoclasts (defined by proteomics) includes cathepsin G and myeloperoxidase; ELMO1 contributes to osteoclast sealing zone formation; a structure-based ELMO1 inhibitory peptide reduces bone resorption in wild-type osteoclasts. Elmo1 KO mouse in four bone-loss models; CRISPR/Cas9 deletion; transcriptomics; proteomics of ELMO1 interactome; osteoclast sealing zone imaging; inhibitory peptide assay Nature communications High 34404802
2010 ELMO1 interacts with COX-2 in human mesangial cells; this protein-protein interaction increases COX-2 cyclooxygenase activity and enhances fibronectin expression; a dominant-negative ELMO1 (ET625, lacking Rac1 activity) also increases COX-2 activity, and Rac1 itself has no effect on COX-2-mediated fibronectin, indicating a Rac1-independent mechanism. Co-immunoprecipitation; COX-2 cyclooxygenase activity assay; fibronectin promoter reporter assay; dominant-negative ELMO1 and constitutively active Rac1 constructs Cellular signalling Medium 20732417
2012 Zebrafish elmo1 is required for macrophage-dependent engulfment of apoptotic cells; in elmo1-deficient macrophages, directed engulfment is rare and may shift to macropinocytosis; elmo1 is not required for apoptotic cell migration to the periphery. Live imaging of apoptotic cells in zebrafish brain; elmo1 morpholino knockdown; time-lapse microscopy of macrophage engulfment Current biology : CB Medium 22503503
2017 Elmo1 interacts with Ephexin4 SH3 domain and N20 region; Elmo1 competes with the Ephexin4 SH3 domain for binding to the N20 region, relieving intermolecular steric inhibition of Ephexin4 and promoting RhoG binding to Ephexin4, thereby activating RhoG for apoptotic cell engulfment. Co-immunoprecipitation; domain mapping; RhoG activation assay; apoptotic cell engulfment assay; deletion and competition binding experiments Scientific reports Medium 28667327
2019 elmo1 mutant zebrafish show reduced neuronal numbers in the posterior lateral line ganglion and defective Schwann cell myelination; these defects are rescued by Rac1 activation; forced early expression of Elmo1 and Rac1 specifically in Schwann cells rescues myelination defects, indicating a cell-autonomous role for Elmo1/Rac1 in radial sorting and myelination. Zebrafish elmo1 mutant; genetic rescue with constitutively active Rac1; Schwann cell-specific rescue; macrophage inhibition experiments Cellular and molecular life sciences : CMLS Medium 31161284
2020 FE65 serves as a functional link between ARF6 and ELMO1 by forming a multimeric complex; FE65 promotes ELMO1 trafficking to the plasma membrane via the endosomal recycling pathway; disruption of FE65-ELMO1 interaction reduces ELMO1 plasma membrane abundance and attenuates ARF6-ELMO1-mediated Rac1 activation and neurite elongation. Co-immunoprecipitation; plasma membrane fractionation; recycling endosome localization assay; FE65 KO; Rac1 activation assay; neurite length measurement FASEB journal Medium 33047393
2023 ELMO1 interacts with NOD2; overexpression of ELMO1 with mutant NOD2 (L1007fs, associated with Crohn's disease) fails to clear adherent invasive E. coli; ELMO1-KO and NOD2-KO enteroid-derived monolayers show higher bacterial loads; combined ELMO1/NOD2 depletion in macrophages impairs bacterial clearance linked to reduced pro-inflammatory cytokines and reactive oxygen species. Co-immunoprecipitation (ELMO1-NOD2 interaction); ELMO1 KO and NOD2 KO mice; enteroid-derived monolayers; bacterial load measurement; cytokine and ROS assays Virulence Medium 36694274
2024 Cryo-EM structures of DOCK5/ELMO1 alone and in complex with RhoG and Rac1: DOCK5/ELMO1 adopts a closed autoinhibited conformation; RhoG binds both ELMO1 and DOCK5 and drives a closed-to-open conformational transition; the open state exposes Rac1 binding sites; RhoG enhances DOCK5/ELMO1 GEF activity and binding affinity for Rac1 (confirmed by SPR); the DOCK5 PIP3-binding site aligns with the RhoG C-terminal lipidation site, suggesting simultaneous membrane binding. Cryo-EM structures of three states; surface plasmon resonance (SPR); in vitro GEF activity assay The Journal of biological chemistry High 38857861
2024 P300 acetyltransferase acetylates ELMO1 at Lys505 (K505); SIRT2 deacetylates this site; K505 acetylation mediates ELMO1-Dock180 interaction and controls Rac1 activation; K505 acetylation does not affect ELMO1 localization or stability but is important for CRC progression. Immunoprecipitation and mass spectrometry to identify K505 acetylation; P300 and SIRT2 identified as writer/eraser; co-immunoprecipitation to assess ELMO1-Dock180 interaction; Rac1 activation assay; CRC cell functional assays Experimental cell research Medium 38750717
2024 ELMO1 depletion decreases SIRT1 deacetylase activity, enhances NF-κB (p65) acetylation, and accelerates intestinal epithelial cell senescence; deletion of ELMO1 leads to senescent IEC accumulation and premature fibrosis in murine colitis; irisin prevents ELMO1 degradation and reduces p65 acetylation and senescence, acting through the ELMO1-SIRT1-p65 pathway. ELMO1 KO mice with colitis model; SIRT1 deacetylase activity assay; p65 acetylation measurement; senescence assays (β-galactosidase, Lamin B1); irisin treatment rescue experiments Gastroenterology report Medium 38756351
2025 Cryo-EM reveals a new symmetrically flattened conformation of DOCK5/ELMO1/RhoG/Rac1 on a lipid membrane-coated grid; conformational changes are driven by interactions with acidic lipids through rotation at the DOCK5-ELMO1 hinge; acidic lipid-driven conformational changes regulate DOCK5/ELMO1 GEF activity on the plasma membrane and are essential for downstream signaling. Cryo-EM on lipid membrane-coated grid; biochemical GEF activity assays with acidic lipids; cellular signaling assays Communications biology High 41233496
2025 ELMO1 depletion in macrophages shifts Salmonella-induced mitochondrial metabolism from oxidative phosphorylation to glycolysis and decreases ATP rate index; ELMO1 depletion upregulates mitochondrial fission protein DRP1; pharmacological DRP1 inhibition links the ELMO1-DRP1 pathway to TNF-α regulation following infection; ELMO1 interacts with Salmonella effector SifA to modulate mitochondrial function. Multinotch MS3-TMT multiplexed proteomics; Seahorse metabolic analysis; ELMO1 KO macrophages and mice; DRP1 pharmacological inhibition; TNF-α cytokine measurement Gut microbes Medium 41250600

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. The Journal of biological chemistry 194 14638695
2005 Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy. Diabetes 163 15793258
2010 Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo. Nature 148 20844538
2007 ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion. Cancer research 116 17671188
2013 Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis. Nature communications 112 23591873
2004 HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis. PLoS biology 107 14737186
2021 TNF-α-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis. Nature communications 101 34508078
2003 DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1. Blood 95 12829596
2009 Confirmation of genetic associations at ELMO1 in the GoKinD collection supports its role as a susceptibility gene in diabetic nephropathy. Diabetes 87 19651817
2008 An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling. Molecular biology of the cell 83 18768751
2009 Variants in intron 13 of the ELMO1 gene are associated with diabetic nephropathy in African Americans. Annals of human genetics 78 19183347
2012 Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms. Proceedings of the National Academy of Sciences of the United States of America 68 22331897
2002 Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. The Journal of biological chemistry 66 12029088
2012 Apoptotic cells are cleared by directional migration and elmo1- dependent macrophage engulfment. Current biology : CB 64 22503503
2015 Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-κB-Snail signaling in glioma. Cancer biology & therapy 60 25870011
2010 The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish. Circulation research 60 20466982
2020 Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state. Nature communications 49 32651375
2016 CC chemokine ligand 18(CCL18) promotes migration and invasion of lung cancer cells by binding to Nir1 through Nir1-ELMO1/DOC180 signaling pathway. Molecular carcinogenesis 45 26756176
2014 Essential role of Elmo1 in Dock2-dependent lymphocyte migration. Journal of immunology (Baltimore, Md. : 1950) 45 24821968
2019 A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis. Nature immunology 44 30643265
2011 The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons. The Journal of biological chemistry 44 21900250
2006 ELMO1 increases expression of extracellular matrix proteins and inhibits cell adhesion to ECMs. Kidney international 44 17021600
2016 High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy. Proceedings of the National Academy of Sciences of the United States of America 39 26858454
2010 ELMO1 variants and susceptibility to diabetic nephropathy in American Indians. Molecular genetics and metabolism 36 20826100
2005 Characterization of a novel interaction between ELMO1 and ERM proteins. The Journal of biological chemistry 36 16377631
2006 Elmo1 inhibits ubiquitylation of Dock180. Journal of cell science 34 16495483
2017 Early detection of gastric cancer using global, genome-wide and IRF4, ELMO1, CLIP4 and MSC DNA methylation in endoscopic biopsies. Oncotarget 33 28418867
2017 ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection. The Journal of infectious diseases 33 29029244
2012 Association of ELMO1 gene polymorphisms with diabetic nephropathy in Chinese population. Journal of endocrinological investigation 31 22842811
2016 ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions. Scientific reports 30 27849017
2021 ELMO1 signaling is a promoter of osteoclast function and bone loss. Nature communications 28 34404802
2019 Differential Targeting of c-Maf, Bach-1, and Elmo-1 by microRNA-143 and microRNA-365 Promotes the Intracellular Growth of Mycobacterium tuberculosis in Alternatively IL-4/IL-13 Activated Macrophages. Frontiers in immunology 28 30941122
2015 The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development. The Journal of biological chemistry 27 25586182
2015 ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome. Cellular and molecular gastroenterology and hepatology 27 26878033
2014 Arhgef16, a novel Elmo1 binding partner, promotes clearance of apoptotic cells via RhoG-dependent Rac1 activation. Biochimica et biophysica acta 27 25063526
2005 Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck. Biochemistry 26 15952790
2021 Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex. Science advances 24 34290093
2018 Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1. The Journal of biological chemistry 24 29615491
2018 Downregulation of Dock1 and Elmo1 suppresses the migration and invasion of triple-negative breast cancer epithelial cells through the RhoA/Rac1 pathway. Oncology letters 24 30127952
2016 ELMO1 Directly Interacts with Gβγ Subunit to Transduce GPCR Signaling to Rac1 Activation in Chemotaxis. Journal of Cancer 24 27313788
2019 Association of CCL2, CCR5, ELMO1, and IL8 Polymorphism with Diabetic Nephropathy in Malaysian Type 2 Diabetic Patients. International journal of chronic diseases 22 30713847
2016 Association between ELMO1 gene polymorphisms and diabetic nephropathy in an Iranian population. Journal of diabetes and metabolic disorders 22 27761430
2010 ELMO1 signaling in apoptotic germ cell clearance and spermatogenesis. Annals of the New York Academy of Sciences 22 20958313
2019 Intergrated analysis of ELMO1, serves as a link between tumour mutation burden and epithelial-mesenchymal transition in hepatocellular carcinoma. EBioMedicine 21 31324602
2019 Annexin A2 interacting with ELMO1 regulates HCC chemotaxis and metastasis. Life sciences 20 30853625
2014 Elmo1 helps dock180 to regulate Rac1 activity and cell migration of ovarian cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20 24819662
2022 Role of ELMO1 in inflammation and cancer-clinical implications. Cellular oncology (Dordrecht, Netherlands) 19 35668246
2016 Association of rs11643718 SLC12A3 and rs741301 ELMO1 Variants with Diabetic Nephropathy in South Indian Population. Annals of human genetics 18 27699784
2020 ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 16 33047393
2019 ELMO1 deficiency enhances platelet function. Blood advances 16 30787021
2019 Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish. Cellular and molecular life sciences : CMLS 16 31161284
2016 Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons. Molecular neurobiology 16 26993296
2012 A link between the cytoplasmic engulfment protein Elmo1 and the Mediator complex subunit Med31. Current biology : CB 15 23273896
2010 Upregulation of fibronectin expression by COX-2 is mediated by interaction with ELMO1. Cellular signalling 15 20732417
2017 Intermolecular steric inhibition of Ephexin4 is relieved by Elmo1. Scientific reports 13 28667327
2024 ELMO1 ameliorates intestinal epithelial cellular senescence via SIRT1/p65 signaling in inflammatory bowel disease-related fibrosis. Gastroenterology report 12 38756351
2017 De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones. eLife 12 28219480
2015 Tyr724 phosphorylation of ELMO1 by Src is involved in cell spreading and migration via Rac1 activation. Cell communication and signaling : CCS 12 26205662
2023 circRNA432 enhances the coelomocyte phagocytosis via regulating the miR-2008-ELMO1 axis in Vibrio splendidus-challenged Apostichopus japonicus. Communications biology 11 36709365
2020 Association of ELMO1 gene polymorphism and diabetic nephropathy among Egyptian patients with type 2 diabetes mellitus. Diabetes/metabolism research and reviews 11 32043290
2023 Targeting Ras-binding domain of ELMO1 by computational nanobody design. Communications biology 10 36932164
2020 Extracellular adenosine enhances pulmonary artery vasa vasorum endothelial cell barrier function via Gi/ELMO1/Rac1/PKA-dependent signaling mechanisms. American journal of physiology. Cell physiology 10 32432925
2019 MiR-HCC2 Up-regulates BAMBI and ELMO1 Expression to Facilitate the Proliferation and EMT of Hepatocellular Carcinoma Cells. Journal of Cancer 10 31293644
2019 Interaction between ELMO1 gene polymorphisms and environment factors on susceptibility to diabetic nephropathy in Chinese Han population. Diabetology & metabolic syndrome 9 31798690
2014 A novel interaction between the SH2 domain of signaling adaptor protein Nck-1 and the upstream regulator of the Rho family GTPase Rac1 engulfment and cell motility 1 (ELMO1) promotes Rac1 activation and cell motility. The Journal of biological chemistry 9 24928514
2023 The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses. Virulence 8 36694274
2018 Silymarin Attenuates ELMO-1 and KIM-1 Expression and Oxidative Stress in the Kidney of Rats with Type 2 Diabetes. Indian journal of clinical biochemistry : IJCB 8 31092990
2017 Gender differences in the association of ELMO1 genetic variants with type 2 diabetes in Tunisian Arabs. Journal of endocrinological investigation 8 28752301
2020 Association of single nucleotide polymorphism (rs741301) of the ELMO1 gene with diabetic kidney disease in Polish patients with type 2 diabetes: a pilot study. Endokrynologia Polska 7 31909452
2018 RhoG-ELMO1-RAC1 is involved in phagocytosis suppressed by mono-butyl phthalate in TM4 cells. Environmental science and pollution research international 7 30350139
2024 ELMO1 regulates macrophage directed migration and attenuates inflammation via NF-κB signaling pathway in primary biliary cholangitis. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 6 38825413
2023 ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine Peritonitis. International journal of molecular sciences 6 37175809
2023 RhoG-Binding Domain of Elmo1 Ameliorates Excessive Process Elongation Induced by Autism Spectrum Disorder-Associated Sema5A. Pathophysiology : the official journal of the International Society for Pathophysiology 6 38133141
2020 Engulfment and cell motility 1 (ELMO1) and apolipoprotein A1 (APOA1) as candidate genes for sickle cell nephropathy. British journal of haematology 6 33216373
2015 [Association of the ELMO1 gene (snp rs1345365) with development of type 2 diabetes mellitus in the Mexican mestizo population]. Investigacion clinica 6 29938964
2016 Knock-down of ELMO1 in Paediatric Rhabdomyosarcoma Cells by Nanoparticle Mediated siRNA Delivery. Nanobiomedicine 5 29942379
2016 [Application of GLAD-PCR analysis for the methylation sites detection in the regulatory areas of tumor-suppressor genes ELMo1 and EsR1 in colorectal cancer]. Voprosy onkologii 5 30444589
2022 Comparative Morphological, Metabolic and Transcriptome Analyses in elmo1 , elmo2 , and elmo3 Zebrafish Mutants Identified a Functional Non-Redundancy of the Elmo Proteins. Frontiers in cell and developmental biology 4 35874819
2021 Functional Verification of Novel ELMO1 Variants by Live Imaging in Zebrafish. Frontiers in cell and developmental biology 4 34993193
2016 Identification of a novel protein interaction between Elmo1 and Cdc27. Biochemical and biophysical research communications 4 26882976
2024 RhoG facilitates a conformational transition in the guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open state. The Journal of biological chemistry 3 38857861
2023 The Potential Impact of MYH9 (rs3752462) and ELMO1 (rs741301) Genetic Variants on the Risk of Nephrotic Syndrome Incidence. Biochemical genetics 3 37594641
2025 DOCK1/ELMO1/Rac1 Signaling is Essential for Vitreous-Induced Migration and Contraction of ARPE19 Cells. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2 39911025
2025 Genomic and cellular context-dependent expression of the human ELMO1 gene transcript variants. Gene 2 40147730
2025 Proteome profiling indicates a link between mitochondrial pathways and the host-microbial sensor ELMO1 following Salmonella infection. Gut microbes 2 41250600
2025 Vitamin B12 Protects the Exacerbated Ischemia-Reperfusion Injury-Induced Chronic Kidney Disease in Mice with Genetically Increased Elmo1. Antioxidants (Basel, Switzerland) 2 41300434
2024 Association between ELMO1 gene polymorphisms and diabetic kidney disease: A systematic review and meta-analysis. PloS one 2 38277369
2024 Proteome profiling identifies a link between the mitochondrial pathways and host-microbial sensor ELMO1 following Salmonella infection. bioRxiv : the preprint server for biology 2 38746404
2024 Acetylation of ELMO1 correlates with Rac1 activity and colorectal cancer progress. Experimental cell research 2 38750717
2023 Overexpression of Dock180 and Elmo1 in Melanoma is Associated with Cell Survival and Migration. Annals of dermatology 2 38086358
2014 [Polymorphism g.37190613 G>A of the ELMO1 gene in the Mexican population: potential marker for clinical-surgical pathology]. Cirugia y cirujanos 2 25167351
2026 Increased Urinary Albumin Excretion But Less Damaged Renal Tubular Structures in Mice with Genetically Decreased Elmo1 Post Ischemia/Reperfusion Injury. Innovation discovery 1 41841030
2025 Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population. FEBS open bio 1 39967558
2025 Diabetic kidney disease and polymorphisms of the ELMO1 and AGTR1 genes: Systematic review. Nefrologia 1 40038011
2025 C1QL1 regulates auditory nerve fibers growth via ELMO1-DOCK180-RAC1 integrin. Acta oto-laryngologica 1 40193629
2025 CXCL12/CXCR4 modulates macrophage efferocytosis to induce glomerular crescent formation and fibrosis via ELMO1/DOCK180/RAC1 signaling in ANCA-associated glomerulonephritis. Cellular and molecular life sciences : CMLS 0 40682610
2025 TFAP2A-mediated Transcriptional Activation of ELMO1 Inhibits Ferroptosis and Promotes Esophageal Squamous Cell Carcinoma Progression. Molecular biotechnology 0 40944775
2025 Conformational alteration of DOCK5•ELMO1 signalosome on lipid membrane. Communications biology 0 41233496
2025 Downregulation of Engulfment and cell motility 1 (Elmo1) induces quiescence and resistance to poly(I:C)-induced apoptosis in endothelial cells. Cell death & disease 0 41422037
2019 Proximity Ligation Assay for the Investigation of the Intramolecular Interaction of ELMO1. Bio-protocol 0 33654944

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