Affinage

Showing ERC1 — ELKS is a alias.

ERC1

ELKS/Rab6-interacting/CAST family member 1 · UniProt Q8IUD2

Length
1116 aa
Mass
128.1 kDa
Annotated
2026-06-09
52 papers in source corpus 25 papers cited in narrative 25 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ERC1 (ELKS/CAST) is a coiled-coil and intrinsically-disordered scaffold protein that organizes membrane-associated assembly platforms for regulated exocytosis, NF-κB signaling, and cell migration through phase-separated condensate formation (PMID:14723704, PMID:31537859, PMID:40646182). At presynaptic active zones it directly binds the RIM PDZ domain and forms hetero-oligomers within the active zone fraction, co-localizing with Bassoon (PMID:14723704, PMID:15976086), and conditional double knockout of ELKS1/2 reduces inhibitory neurotransmitter release and action potential-triggered Ca2+ influx (PMID:25209271). ELKS positively regulates voltage-gated Ca2+ channel density and vesicle fusogenicity at central synapses (PMID:29996090), and at pancreatic beta cells it binds the GK domain of the VDCC-β subunit to support L-type Ca2+ current and first-phase insulin secretion at the plasma-membrane vascular face (PMID:15888548, PMID:30699350). ELKS recognizes Rab6B via a C-terminal helical hairpin, and its liquid-liquid phase separation captures Rab6-coated vesicles at exocytotic sites (PMID:37172719). Independently of its synaptic role, ELKS is an essential regulatory subunit of the IKK complex that recruits IκBα to drive NF-κB target gene expression (PMID:15218148); upon genotoxic stress it is K63-polyubiquitinated by XIAP/UBC13 to recruit the TAK1/TAB2-3 complex and activate IKK (PMID:20932476). In migrating cells ERC1 forms liquid-like condensates with liprin-α1 and LL5β at the leading edge that promote focal adhesion turnover and active integrin β1 internalization, with the condensate biophysical properties themselves being required for tumor cell motility (PMID:24982445, PMID:27659488, PMID:40646182). Dengue virus NS5 and HCV NS3 target ELKS to modulate NF-κB responses and secretion (PMID:37252973, PMID:16033967). ELKS coupled the dimerization domains it uses for oligomerization were first identified as a constitutively activating fusion partner of the RET kinase in papillary thyroid carcinoma (PMID:10337992).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1999 Medium

    The first characterization established ELKS as a multi-coiled-coil dimerizing protein, discovered through an oncogenic rearrangement that fused its oligomerization domains to RET to constitutively activate the kinase.

    Evidence cDNA cloning of a thyroid carcinoma rearrangement and in vitro synthesis of chimeric proteins with anti-phosphotyrosine immunoblotting

    PMID:10337992 PMID:12203787

    Open questions at the time
    • Did not define the normal cellular function of ELKS
    • Multiple splice isoforms identified but their distinct functions not resolved
  2. 2004 High

    Two parallel studies revealed dual functions: ELKS as a direct RIM-binding active zone scaffold, and as an essential IKK complex subunit recruiting IκBα for NF-κB signaling, establishing the gene's bifurcated biology.

    Evidence Subcellular fractionation, reciprocal Co-IP, immunoEM in rat brain; RNAi and NF-κB reporter assays in cells

    PMID:14723704 PMID:15218148

    Open questions at the time
    • Relationship between synaptic and NF-κB pools unclear
    • Structural basis of RIM and IκBα binding not resolved
  3. 2005 High

    In vivo genetics in C. elegans showed ELKS-1 binds the RIM PDZ domain and anchors a RIM fragment to release sites, but with redundant anchoring mechanisms, refining how ELKS contributes to active zone assembly.

    Evidence C. elegans loss-of-function mutants with domain-truncation localization and behavioral assays

    PMID:15976086

    Open questions at the time
    • Identity of redundant anchoring factors not defined
    • Quantitative contribution to release not measured
  4. 2005 High

    ELKS was extended beyond neurons to endocrine secretion, shown to organize docked insulin granules and support glucose-evoked insulin release in beta cells.

    Evidence TIRF and immunoEM, dominant-negative fragment overexpression, siRNA, and insulin secretion assays; plus HCV NS3 interaction shown the same year

    PMID:15888548 PMID:16033967

    Open questions at the time
    • Mechanism linking docking to Ca2+ channels not yet defined
    • Whether secretion role uses the same RIM interface unknown
  5. 2006 High

    Genetic and biochemical work linked ELKS to liprin-α (SYD-2) for active zone assembly and to the RIM2-Munc13 pathway for Ca2+-dependent exocytosis, connecting it into a broader scaffold network.

    Evidence C. elegans epistasis with Co-IP of mutant SYD-2; PC12 overexpression/deletion constructs with growth hormone secretion assay

    PMID:16716196 PMID:17115037

    Open questions at the time
    • Direct liprin-ELKS binding interface not mapped
    • Stoichiometry of the scaffold network unknown
  6. 2010 High

    The NF-κB role was mechanized for genotoxic stress: ELKS is K63-polyubiquitinated by XIAP/UBC13 to recruit TAK1 via TAB2/3, assembling the kinase complexes needed for IKK activation.

    Evidence Ubiquitination assays with defined E3/E2, Co-IP of assembled complexes, RNAi and dominant-negative controls

    PMID:20932476

    Open questions at the time
    • Ubiquitination site(s) on ELKS not mapped
    • Signal terminating the ubiquitin-dependent assembly unknown
  7. 2014 High

    Definitive mouse genetics quantified ELKS's synaptic role, and a new cell-migration function emerged through ERC1-liprin-α1-LL5β complexes regulating integrin turnover.

    Evidence Conditional ELKS1/2 double-KO with electrophysiology, Ca2+ imaging and EM; siRNA depletion with invasion and integrin internalization assays

    PMID:24982445 PMID:25209271

    Open questions at the time
    • How ELKS sets Ca2+ influx without changing channel levels at inhibitory terminals unresolved
    • Link between migration and synaptic scaffold functions unclear
  8. 2016 Medium

    The migration function was refined: ERC1 and liprin-α1 co-localize with active integrin clusters to drive focal adhesion disassembly and influence Rab7 endosome positioning.

    Evidence siRNA, dominant-negative liprin-N expression, live imaging and Co-IP

    PMID:27659488

    Open questions at the time
    • Direct link to endosomal trafficking machinery not established
    • Causal chain from adhesion disassembly to protrusion incomplete
  9. 2018 High

    Conditional KO at the calyx of Held showed CAST/ELKS positively regulate CaV2.1 channel density and control vesicle fusogenicity through a post-priming step, mechanizing the Ca2+ influx phenotype.

    Evidence Conditional KO mice with patch-clamp, EM and immunohistochemistry

    PMID:29996090

    Open questions at the time
    • Molecular basis of CaV2.1 density regulation not identified
    • Identity of the post-priming step molecular target unknown
  10. 2019 High

    Two studies provided molecular mechanism: ELKS directly binds the VDCC-β GK domain to support beta-cell Ca2+ current and insulin secretion, and ERC1 forms flexible dimers and liquid-like condensates hosting motility partners.

    Evidence Beta-cell-specific KO with Co-IP, Ca2+ imaging, patch-clamp; EM, single-molecule analysis and FRAP for condensates

    PMID:30699350 PMID:31537859

    Open questions at the time
    • How VDCC-β binding sets channel density mechanistically unclear
    • Functional necessity of condensates not yet tested directly
  11. 2021 Medium

    Phase separation was shown to govern active zone organization, with oligomerized liprin-α2 promoting ELKS N-terminal phase separation and controlling protein distributions among ELKS, RIM and RIM-BP.

    Evidence Structural/biochemical characterization with phase separation and co-condensation assays

    PMID:33761347

    Open questions at the time
    • In vivo relevance of the reconstituted phase behavior not confirmed
    • Quantitative effect on release not measured
  12. 2023 High

    A structural and mechanistic synthesis defined how ELKS captures vesicles: a C-terminal helical hairpin recognizes Rab6B and LLPS enhances competition for Rab6 to recruit vesicles to exocytotic sites; complementary work mapped the LL5β binding region and showed viral and CaV interactions.

    Evidence Rab6B-ELKS1 crystal structure with LLPS and vesicle capture assays; NMR mapping of ERC1-LL5β; DENV NS5 proteomics; Drosophila single-molecule imaging

    PMID:36800417 PMID:37172719 PMID:37252973 PMID:37437062

    Open questions at the time
    • Whether Rab6 capture and synaptic RIM scaffolding use overlapping ELKS surfaces unclear
    • How NS5 selectively degrades ELKS at the molecular level incomplete
  13. 2025 Medium

    Functional dissection established that condensate biophysical properties per se, driven by the ERC1 N-terminal IDR, are required for tumor cell motility, and that directed insulin secretion occurs at margins of ELKS/LL5β patches lacking microtubules.

    Evidence In vitro/in-cell phase separation with FRAP and domain deletions plus motility assays; TIRF of intact islets with microtubule co-localization

    PMID:40366873 PMID:40646182

    Open questions at the time
    • Mechanistic link between condensate material properties and motility machinery unknown
    • How microtubule absence and ELKS content jointly set secretion hot spots unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown how a single scaffold reconciles its distinct roles across active zones, endocrine secretion, NF-κB signaling and cell migration, and whether isoform identity or phase-separation state selects between these functions.
  • No unified model of how ERC1 isoforms partition among its functions
  • Structural basis for mutually exclusive vs. coexisting partner interactions undefined
  • No human Mendelian disease association established in the corpus

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 5
Localization
GO:0005886 plasma membrane 5 GO:0005829 cytosol 2 GO:0031410 cytoplasmic vesicle 2
Pathway
R-HSA-112316 Neuronal System 4 R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-168256 Immune System 3 R-HSA-162582 Signal Transduction 2
Partners
BASSOONCACNBIKBKBLIPRIN-Α1LL5ΒRAB6BRIM1
Complex memberships
ERC1-liprin-α1-LL5β leading-edge complexIKK complexpresynaptic active zone cytomatrix

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 ELKS (ERC1) encodes a 948 amino acid protein with multiple coiled-coil domains that can dimerize; its 5' portion was found fused to the RET tyrosine kinase domain in a papillary thyroid carcinoma, and the ELKS dimerization domains constitutively activate RET's cytoplasmic tyrosine kinase. cDNA cloning, gene rearrangement identification, in vitro synthesis of chimeric proteins with anti-phosphotyrosine immunoblotting Genes, chromosomes & cancer Medium 10337992
2002 The ELKS gene produces at least five isoforms (alpha through epsilon) by alternative splicing; all ELKS-RET chimeric fusion proteins containing the ELKS oligomerization (coiled-coil) domains are constitutively phosphorylated at tyrosine residues, whereas native RET is not. RT-PCR isoform characterization, in vitro synthesis of fusion proteins, immunoblotting with anti-phosphotyrosine antibody Genes, chromosomes & cancer Medium 12203787
2004 CAST2 (the rat ortholog of human ELKS/ERC1) directly binds RIM1 through its C-terminal domain and forms a hetero-oligomer with CAST1; it is tightly associated with the synaptic active zone fraction in rat brain and co-localizes with Bassoon at hippocampal synapses. Subcellular fractionation, co-immunoprecipitation, immunoelectron microscopy, primary neuronal culture co-localization Genes to cells : devoted to molecular & cellular mechanisms Medium 14723704
2004 ELKS is an essential regulatory subunit of the IκB kinase (IKK) complex; silencing ELKS by RNAi blocks NF-κB target gene expression (IκBα, COX-2, IL-8) and prevents protection from apoptosis. ELKS functions by recruiting IκBα to the IKK complex. RNAi knockdown, NF-κB reporter assays, co-immunoprecipitation, apoptosis assays Science (New York, N.Y.) High 15218148
2005 C. elegans ELKS-1 directly interacts with the PDZ domain of RIM (UNC-10) at the active zone. RIM truncations containing only the PDZ and C2A domains target to release sites in an ELKS-dependent manner, indicating ELKS anchors this RIM fragment. However, RIM localizes without ELKS and ELKS localizes without RIM, demonstrating redundant anchoring mechanisms. Genetic loss-of-function (C. elegans mutants), behavioral assays, in vivo expression of PDZ domain truncations, fluorescence localization The Journal of neuroscience High 15976086
2005 ELKS co-localizes with docked insulin granules and syntaxin 1 clusters at the plasma membrane of pancreatic beta cells. Introduction of the Bassoon-binding region of ELKS into insulin-producing cells markedly reduced insulin granule docking and fusion, and siRNA-mediated ELKS knockdown reduced glucose-evoked insulin release. Confocal and immunoelectron microscopy, total internal reflection fluorescence (TIRF) microscopy, dominant-negative fragment overexpression, siRNA knockdown, insulin secretion assay Molecular biology of the cell High 15888548
2006 C. elegans SYD-2 (Liprin-α) gain-of-function mutation promotes presynaptic active zone assembly through ELKS-1; the syd-2(gf) activity requires elks-1 but not unc-10/RIM. The gain-of-function mutant SYD-2 shows increased physical association with ELKS. Genetic epistasis in C. elegans (double mutants), co-immunoprecipitation of mutant SYD-2 with ELKS Nature neuroscience High 17115037
2006 ELKS is involved in Ca2+-dependent exocytosis from PC12 cells; overexpression of full-length ELKS increases stimulated exocytosis, an effect abolished by deletion of either the C-terminal IWA motif (required for RIM2 binding) or the central Bassoon-binding region. ELKS promotes exocytosis at least partly via the RIM2-Munc13-1 pathway. Overexpression of full-length and deletion constructs, human growth hormone secretion assay, immunocytochemistry co-localization Genes to cells : devoted to molecular & cellular mechanisms Medium 16716196
2010 Upon genotoxic stress, ATM activates TAK1 in a manner dependent on NEMO and ELKS. XIAP and UBC13 catalyze K63-linked polyubiquitination of ELKS, which then recruits TAK1 via its ubiquitin-binding subunits TAB2/3, assembling the TAK1/TAB2/3 and NEMO/IKK complexes to activate IKK and NF-κB. Co-immunoprecipitation, ubiquitination assays, RNAi knockdown, dominant-negative constructs, NEMO mutant analysis Molecular cell High 20932476
2014 ERC1a (an isoform of ERC1) forms a functional complex with liprin-α1 and LL5α/LL5β at the protruding edge of migrating cells. Depletion of ERC1 impairs cell migration, invasion on extracellular matrix, lamellipodial persistence, and internalization of active integrin β1 receptors needed for adhesion turnover. siRNA depletion, live cell imaging, invasion assays, integrin internalization assays, co-localization by fluorescence microscopy Journal of cell science Medium 24982445
2014 Simultaneous conditional knockout of ELKS1 and ELKS2 in hippocampal neurons reduces neurotransmitter release at inhibitory synapses by ~50% and decreases release probability, accompanied by a ~30% reduction in action potential-triggered Ca2+ influx at inhibitory nerve terminals, without affecting synapse number or ultrastructure or presynaptic Ca2+ channel levels. Conditional knockout mice, electrophysiology (patch-clamp), Ca2+ imaging, electron microscopy, immunohistochemistry The Journal of neuroscience High 25209271
2016 Liprin-α1 and ERC1 co-localize with active integrin β1 clusters at the cell edge and promote focal adhesion disassembly. Displacing ERC1 from the cell edge (via dominant-negative liprin-N fragment) inhibits focal adhesion disassembly and impairs protrusion; liprin-α1 and ERC1 influence the localization of peripheral Rab7-positive endosomes. siRNA depletion, dominant-negative expression, live cell imaging, co-immunoprecipitation, fluorescence co-localization Scientific reports Medium 27659488
2018 Deletion of the CAST/ELKS protein family at the calyx of Held reduces CaV2.1 current density and channel number, and increases release probability while decreasing the readily releasable pool, with no change in active zone ultrastructure. CAST/ELKS are positive regulators of CaV2.1 channel density and regulate vesicle fusogenicity through a post-priming step. Conditional knockout mice, patch-clamp electrophysiology, electron microscopy, immunohistochemistry Cell reports High 29996090
2019 ELKS directly interacts with the GK domain of the voltage-dependent Ca2+ channel (VDCC) β subunit. Beta cell-specific ELKS knockout mice show impaired first-phase insulin secretion, reduced L-type VDCC current density, and markedly decreased local Ca2+ signals at the ELKS-localized vascular face of the β cell plasma membrane. Beta cell-specific knockout mice, co-immunoprecipitation (ELKS with VDCC-β subunit), in situ Ca2+ imaging, patch-clamp electrophysiology Cell reports High 30699350
2019 ERC1 forms an extended flexible dimer and assembles into cytoplasmic condensates with liquid-phase behavior modulated by a predicted intrinsically disordered region. These condensates specifically host liprin-α1 and other cell motility partners; liprin-α1 influences the dynamic behavior of the condensates but is not required for their formation. Electron microscopy, single molecule analysis, fluorescence microscopy, FRAP, domain-deletion analysis Scientific reports Medium 31537859
2021 Oligomerized liprin-α2 coiled-coil domain promotes phase separation of the ELKS N-terminal segment through multivalent interactions, and liprin-α2, by regulating interplay between ELKS and RIM/RIM-BP phase separations, controls protein distributions within the active zone. Structural analysis (crystal/biochemical characterization), phase separation assays, gain-of-function mutation analysis, co-condensation experiments Cell reports Medium 33761347
2023 Dengue virus NS5 protein binds and degrades ERC1 to antagonize NF-κB activation, limit proinflammatory cytokine secretion, and reduce cell migration. The degradation involves unique properties of the methyltransferase domain of NS5 not conserved among all four DENV serotypes. Proteomics (NS5-ERC1 interaction), knockdown/overexpression, NF-κB reporter assays, chimeric virus construction, cytokine measurement Proceedings of the National Academy of Sciences of the United States of America High 37252973
2023 Crystal structure of the Rab6B–ELKS1 complex reveals that a C-terminal segment of ELKS1 forms a helical hairpin to recognize Rab6B through a unique binding mode. Liquid-liquid phase separation of ELKS1 enhances competition with other Rab6 effectors for Rab6B binding and recruits Rab6B-coated vesicles to exocytotic sites, promoting vesicle exocytosis. Crystal structure determination, biochemical binding assays, LLPS assays, vesicle capture assays, cellular exocytosis assays The Journal of biological chemistry High 37172719
2023 The ERC1 minimal region for LL5β binding was mapped to ERC1(270-370) and LL5β(381-510); these fragments undergo direct high-affinity interaction involving intrinsically disordered regions (confirmed by NMR). Expression of LL5β(381-510) displaces endogenous ERC1 from the cell edge, reduces invadopodia density, and inhibits transwell invasion. Co-immunoprecipitation, NMR spectroscopy, domain-deletion mapping, dominant-negative fragment expression, invasion assays PloS one Medium 37437062
2023 During presynaptic homeostatic potentiation at Drosophila active zones, the ELKS-family protein Bruchpilot compacts its nanoscale distribution; this compaction is coupled to increased numbers and decreased mobility of the CaV2.1 ortholog Cacophony (Cac), dependent on direct interaction between Cac's intracellular C-terminus and the membrane-proximal N-terminal region of Bruchpilot/ELKS. In vivo single-molecule imaging of endogenously tagged proteins, presynaptic homeostatic potentiation paradigm, genetic disruption of Cac-Bruchpilot interaction Science advances Medium 36800417
2025 The shortest N-terminal region of ERC1 (residues 1-244, including an intrinsically disordered region) is sufficient to drive phase separation in vitro and in cells. Deletion of this region alters the biophysical properties of ERC1 condensates and impairs tumor cell motility, without abolishing condensate formation or partner interactions, demonstrating that condensate properties per se are important for ERC1 function in migration. Phase separation assays in vitro and in cells, FRAP, domain-deletion constructs, tumor cell motility assays Communications biology Medium 40646182
2025 Directed insulin secretion from beta cells occurs preferentially at margins of ELKS/LL5β patches at sites devoid of microtubules; TIRF microscopy of intact islets shows secretion restricted to ~5% of ELKS/LL5β patch area, and local MT disassembly together with optimal ELKS content predicts secretion hot spots. TIRF microscopy of intact mouse islets, live imaging of single secretion events, microtubule co-localization analysis Molecular biology of the cell Medium 40366873
2009 ELKS is expressed in RBL-2H3 mast cells and positively regulates exocytotic release; overexpression increases and knockdown decreases exocytotic activity. ELKS translocates to the plasma membrane after antigen stimulation. Overexpression, siRNA knockdown, immunocytochemistry, live YFP-ELKS imaging, exocytosis assay Cellular immunology Medium 19515363
2005 HCV NS3 protein physically interacts with ELKS-δ and ELKS-α (ERC1 isoforms) in cultured human cells including HCV replicon-containing cells; NS3 enhances secretion of alkaline phosphatase, with the degree of secretion enhancement correlating with NS3-ELKS-δ binding strength. Yeast two-hybrid, co-immunoprecipitation, GST pull-down, confocal and immunoelectron microscopy, SEAP secretion assay The Journal of general virology Medium 16033967
2020 In mouse forebrain, CAST is the dominant active zone scaffold and ELKS can support CAST function. Combined conditional knockout of CAST and ELKS in the forebrain causes neonatal lethality likely due to impaired sensory-to-motor neurotransmission, while single ELKS KO alone has less severe effects. Conditional knockout mice (CaMKII-Cre), histological analysis, behavioral observation, anatomical mapping of sensory circuits Molecular brain Medium 31996256

Source papers

Stage 0 corpus · 52 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. Neuron 735 16543132
1998 A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. Cell 265 9778250
2004 Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit. Science (New York, N.Y.) 180 15218148
2006 SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS. Nature neuroscience 179 17115037
2010 ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. Molecular cell 171 20932476
1999 Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma. Genes, chromosomes & cancer 106 10337992
2005 ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy. Molecular biology of the cell 91 15888548
2011 ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot. Neuron 84 22153374
2004 CAST2: identification and characterization of a protein structurally related to the presynaptic cytomatrix protein CAST. Genes to cells : devoted to molecular & cellular mechanisms 71 14723704
2014 Liprin-α1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration. Journal of cell science 66 24982445
2010 CAST and ELKS proteins: structural and functional determinants of the presynaptic active zone. Journal of biochemistry 64 20581014
2014 The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 62 25209271
2018 CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse. Cell reports 58 29996090
2012 12p13.33 microdeletion including ELKS/ERC1, a new locus associated with childhood apraxia of speech. European journal of human genetics : EJHG 57 22713806
2005 Redundant localization mechanisms of RIM and ELKS in Caenorhabditis elegans. The Journal of neuroscience : the official journal of the Society for Neuroscience 56 15976086
2016 Liprin-α1 and ERC1 control cell edge dynamics by promoting focal adhesion turnover. Scientific reports 41 27659488
2021 Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins. Cell reports 39 33761347
2018 ELKS active zone proteins as multitasking scaffolds for secretion. Open biology 38 29491150
2023 Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca2+ channels drives sustained active zone potentiation. Science advances 35 36800417
2019 The ERC1 scaffold protein implicated in cell motility drives the assembly of a liquid phase. Scientific reports 33 31537859
2006 ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+-dependent exocytosis from PC12 cells. Genes to cells : devoted to molecular & cellular mechanisms 31 16716196
2019 ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells. Cell reports 29 30699350
2002 Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma. Genes, chromosomes & cancer 24 12203787
2016 SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling. PloS one 23 27224062
2005 Low prevalence of RET rearrangements (RET/PTC1, RET/PTC2, RET/PTC3, and ELKS-RET) in sporadic papillary thyroid carcinomas in Taiwan Chinese. Thyroid : official journal of the American Thyroid Association 23 15876154
2023 Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation. Proceedings of the National Academy of Sciences of the United States of America 22 37252973
2020 Presynaptic development is controlled by the core active zone proteins CAST/ELKS. The Journal of physiology 22 32304329
2019 Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells. Molecular metabolism 19 31500835
2018 Association of CAST2, HSP90AA1, DNAJA1 and HSPB1 genes with meat tenderness in Nellore cattle. Meat science 19 29331838
2016 Sake yeast YHR032W/ERC1 haplotype contributes to high S-adenosylmethionine accumulation in sake yeast strains. Journal of bioscience and bioengineering 14 27567046
2009 Involvement of ELKS, an active zone protein, in exocytotic release from RBL-2H3 cells. Cellular immunology 14 19515363
2007 Localization of the active zone proteins CAST, ELKS, and Piccolo at neuromuscular junctions. Neuroreport 13 17435594
2023 Structural basis of ELKS/Rab6B interaction and its role in vesicle capturing enhanced by liquid-liquid phase separation. The Journal of biological chemistry 11 37172719
2005 Hepatitis C virus NS3 protein interacts with ELKS-{delta} and ELKS-{alpha}, members of a novel protein family involved in intracellular transport and secretory pathways. The Journal of general virology 11 16033967
1986 Papillomavirus DNA associated with pulmonary fibromatosis in European elks. Journal of virology 11 3005617
2021 Circular RNA circ_0084927 regulates proliferation, apoptosis, and invasion of breast cancer cells via miR-142-3p/ERC1 pathway. American journal of translational research 10 34150003
2017 Drosophila Syd-1 Has RhoGAP Activity That Is Required for Presynaptic Clustering of Bruchpilot/ELKS but Not Neurexin-1. Genetics 10 29217522
2022 FGFR2-ERC1: A Subtype of FGFR2 Oncogenic Fusion Variant in Lung Adenocarcinoma and the Response to Anlotinib. OncoTargets and therapy 9 35712652
2000 Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma. Journal of human genetics 9 10697956
2013 Antibodies to active zone protein ERC1 in Lambert-Eaton myasthenic syndrome. Human immunology 8 23583364
2021 Case report: identification of ERC1-RET fusion in a patient with pancreatic ductal adenocarcinoma. Gland surgery 7 34733735
2020 Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data. Neurobiology of aging 6 32768867
2025 Directed insulin secretion from beta cells occurs at cortical sites devoid of microtubules at the edges of ELKS/LL5β patches. Molecular biology of the cell 4 40366873
2025 Biomolecular condensation of ERC1 recruits ATG8 and NBR1 to drive autophagosome formation for plant heat tolerance. Proceedings of the National Academy of Sciences of the United States of America 2 41213015
2024 Biomolecular condensation of ERC1 recruits ATG8 and NBR1 to drive autophagosome formation for plant heat tolerance. bioRxiv : the preprint server for biology 2 39314317
2023 Interfering with the ERC1-LL5β interaction disrupts plasma membrane-Associated platforms and affects tumor cell motility. PloS one 2 37437062
2020 The sake yeast YHR032W/ERC1 allele contributes to the regulation of the tetrahydrofolate content in the folate synthetic pathway in sake yeast strains. Bioscience, biotechnology, and biochemistry 2 31961264
2025 Directed insulin secretion from beta cells occurs at cortical sites devoid of microtubules at the edges of ELKS/LL5β patches. bioRxiv : the preprint server for biology 1 39553950
2025 Altering the biophysical properties of ERC1/ELKS-driven condensates interferes with cell motility. Communications biology 1 40646182
2023 Successful Crizotinib-targeted Therapy of Pediatric Unresectable ERC1::ALK Fusion Sarcoma. Journal of pediatric hematology/oncology 1 38099690
2025 CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge. Journal of cell science 0 41277545
2020 Double deletion of the active zone proteins CAST/ELKS in the mouse forebrain causes high mortality of newborn pups. Molecular brain 0 31996256

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