Affinage

DOCK7

Dedicator of cytokinesis protein 7 · UniProt Q96N67

Length
2140 aa
Mass
242.6 kDa
Annotated
2026-06-14
29 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DOCK7 is a DOCK180-family guanine nucleotide exchange factor that activates the Rho-family GTPases Rac1 and Cdc42 to drive cytoskeletal remodeling across neuronal development, cell migration, and the genotoxic stress response (PMID:16982419, PMID:23718289). Its catalytic DHR2 domain efficiently exchanges nucleotide only on prenylated, membrane-anchored Cdc42/Rac1, and an N-terminal site within DHR2 binds GTP-loaded GTPase to recruit the domain to the membrane and create positive cooperativity that accelerates exchange (PMID:23718289). DOCK7 activity is gated by upstream receptor and scaffold inputs: the NRG1 receptor ErbB2 directly binds and phosphorylates DOCK7 at Tyr-1118 to stimulate GEF activity and downstream JNK signaling (PMID:18426980), and DOCK7 is similarly engaged by ErbB4, RAGE, and the c-Met/Gab1 axis to channel receptor signals into Rac/Cdc42 activation (PMID:23254359, PMID:24440718, PMID:24518591). In the nervous system DOCK7 specifies the axon through a Rac→stathmin/Op18 microtubule-destabilization pathway (PMID:16982419), controls cortical neurogenesis by antagonizing TACC3 to regulate interkinetic nuclear migration and progenitor fate (PMID:22842144), governs postnatal neuroblast tangential migration via parallel Rac–microtubule and MPRIP–RhoA–actin pathways (PMID:29089377), and negatively regulates Schwann cell differentiation and myelination by balancing Rac/Cdc42/JNK against Rho/ROCK signaling (PMID:21880919). Beyond neurons, DOCK7 partners with myosin VI/MYO6 to spatially restrict Rac1 activity during protrusion formation and collective epithelial migration (PMID:27018747, PMID:37590133), with NBEAL2 to maintain platelet α-granule content and actin-dependent platelet activation (PMID:29187380), and acts in the DNA replication stress response by being recruited via MDC1 to replication forks, where DOCK7→Rac1/Cdc42→PAK1 signaling phosphorylates and stabilizes RPA1 (PMID:33704464).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2006 High

    Established DOCK7 as a Rac activator with a defined developmental output by linking it to axon specification, answering what cellular process this GEF controls.

    Evidence shRNA knockdown, overexpression, localization, and phospho-stathmin assays in hippocampal neurons

    PMID:16982419

    Open questions at the time
    • Did not define how DOCK7 itself is activated upstream
    • Direct GEF biochemistry on purified components not shown
  2. 2008 High

    Identified a direct upstream activator, showing ErbB2 phosphorylates DOCK7 at Tyr-1118 to switch on its GEF activity, connecting receptor tyrosine kinase signaling to Rac/Cdc42/JNK.

    Evidence Co-IP, Y1118F mutagenesis, GTPase pull-down assays, and Schwann cell migration rescue

    PMID:18426980

    Open questions at the time
    • Structural basis of phospho-activation not resolved
    • Whether other RTKs use the same site untested at the time
  3. 2009 High

    Genetic loss-of-function alleles established a non-redundant in vivo requirement for DOCK7 in melanocyte distribution, extending its physiological roles beyond neurons.

    Evidence Forward genetic mapping and allele complementation of misty/moonlight mouse mutants

    PMID:19202056

    Open questions at the time
    • Molecular pathway linking DOCK7 to melanocyte biology not defined
    • GTPase effector in this context unknown
  4. 2011 High

    Defined DOCK7 as a negative regulator of myelination, showing it tunes the balance between Rac/Cdc42/JNK and Rho/ROCK signaling to time Schwann cell differentiation.

    Evidence siRNA in primary Schwann cells, shRNA transgenic mice, GTPase activity assays, myelin thickness measurement

    PMID:21880919

    Open questions at the time
    • Mechanism coupling DOCK7 to Rho/ROCK suppression unclear
    • Direct substrates beyond GTPases not identified
  5. 2012 High

    Expanded the partner repertoire and developmental reach, identifying TACC3 antagonism as the mechanism by which DOCK7 controls interkinetic nuclear migration and progenitor-versus-differentiation fate.

    Evidence In utero electroporation gain/loss-of-function, reciprocal Co-IP of DOCK7 and TACC3, INM and differentiation assays

    PMID:22842144

    Open questions at the time
    • Whether GEF activity is required for TACC3 antagonism not separated
    • Direct vs. indirect binding to TACC3 not structurally defined
  6. 2012 Medium

    Implicated DOCK7 in receptor-driven cancer cell migration through a new receptor partner, RAGE, transducing signal to Cdc42.

    Evidence IP-LC-MS/MS interactor screen, Co-IP validation, Cdc42 activity assay, knockdown migration/morphology readouts

    PMID:23254359

    Open questions at the time
    • Single-lab study without reciprocal in vivo validation
    • Direct binding interface with RAGE not mapped
  7. 2012 Medium

    Linked DOCK7 to the actin motor myosin VI, providing a candidate mechanism for spatially organizing its activity in neurons.

    Evidence Pull-down + mass spectrometry, endogenous Co-IP, and co-localization in PC12 cells and hippocampal neurons

    PMID:22475431

    Open questions at the time
    • No functional consequence of the interaction shown in this study
    • No mutagenesis defining the binding interface
  8. 2013 High

    Resolved the catalytic mechanism, showing DHR2 is a GEF specific for prenylated, membrane-bound Cdc42/Rac1 and uses an allosteric GTP-loaded-GTPase site to drive cooperative, membrane-localized exchange.

    Evidence Liposome reconstitution, in vitro GEF assays with prenylated vs. non-prenylated GTPases, active-site and allosteric-site mutagenesis

    PMID:23718289

    Open questions at the time
    • No full-length structure
    • How upstream phosphorylation modulates this catalytic cycle not integrated
  9. 2014 Medium

    Generalized the receptor-coupling principle to additional RTK contexts, showing DOCK7 activates ErbB4 in chandelier cells and engages c-Met via Gab1 to drive glioblastoma invasion.

    Evidence In utero electroporation manipulation and Co-IP for ErbB4; Co-IP, Gab1-dependence, Rac1 assay, and invasion assays for c-Met

    PMID:24440718 PMID:24518591

    Open questions at the time
    • Whether DOCK7 phosphorylation site is conserved across these receptors not tested
    • Single-lab functional data per context
  10. 2016 Medium

    Established functional coupling between myosin VI and DOCK7, showing MYO6 promotes DOCK7 Tyr1118 phosphorylation and Rac1 activation required for NGF-induced protrusion.

    Evidence Domain-mapping Co-IP, MYO6 knockdown with Rac1 assay and pY1118 immunoblot, cargo-domain dominant-negative

    PMID:27018747

    Open questions at the time
    • Mechanism by which MYO6 enhances Tyr1118 phosphorylation unclear
    • Single-lab study
  11. 2017 High

    Dissected DOCK7 control of neuroblast tangential migration into two molecularly distinct outputs, a Rac-microtubule leading-process pathway and an MPRIP-RhoA-actin rear pathway.

    Evidence In vivo knockdown by electroporation, live imaging, cytoskeletal dynamics and Rac assays, dominant-negative pathway components

    PMID:29089377

    Open questions at the time
    • How DOCK7 partitions between the two pathways spatially not resolved
    • Upstream activator in migrating neuroblasts not identified
  12. 2017 High

    Revealed a non-cytoskeletal-developmental role in platelet biology, showing NBEAL2 binding retains DOCK7 in alpha-granules and supports actin-dependent platelet activation.

    Evidence Reciprocal Co-IP, proximity ligation, fractionation, GPS-patient and Nbeal2-KO mouse platelet assays

    PMID:29187380

    Open questions at the time
    • Whether DOCK7 GEF activity is required for platelet phenotype not isolated
    • Granule cargo function vs. signaling role not fully separated
  13. 2021 High

    Placed DOCK7 in the DNA replication stress response, defining an ATR/MDC1-recruited DOCK7→Rac1/Cdc42→PAK1→RPA1 cascade that stabilizes chromatin-loaded RPA1.

    Evidence Chromatin fractionation, Co-IP with MDC1, phospho-site mapping, GTPase and PAK1 kinase assays, RPA1 phospho-mutant analysis, camptothecin sensitivity

    PMID:33704464

    Open questions at the time
    • How a cytoplasmic GEF accesses chromatin GTPase pools not fully explained
    • Single-lab study without independent replication
  14. 2023 Medium

    Demonstrated spatial control of Rac1 in epithelia, showing a planar-polarized MYO6-DOCK7 axis restricts RAC1 to drive cryptic lamellipodia and collective tissue motion.

    Evidence Live imaging, MYO6/DOCK7 knockdown, RAC1 activity biosensor, collective migration tracking in mammary monolayers

    PMID:37590133

    Open questions at the time
    • Single-lab study
    • Molecular basis of planar polarization of the axis not defined
  15. 2024 Medium

    Extended DOCK7 signaling to intercellular transfer, showing TAM-EV-delivered DOCK7 activates RAC1-AKT-FOXO1-ABCA1 to promote cholesterol efflux and colorectal cancer metastasis.

    Evidence EV isolation/LC-MS, DOCK7 knockdown, RAC1 assay, AKT/FOXO1 immunoblot, cholesterol efflux assay, liver metastasis model

    PMID:38385857

    Open questions at the time
    • Single-lab study
    • Whether transferred DOCK7 retains canonical GEF mechanism in recipient cells untested
  16. 2025 Medium

    Connected the ErbB2-DOCK7 axis to a disease-linked variant, showing it mediates aberrant neuronal process elongation from an ASD-associated Sema5A mutation.

    Evidence shRNA knockdown, ErbB2 kinase inhibition, Rac1/Cdc42 assays, process-length measurement in cortical neurons and N1E-115 cells

    PMID:41226692

    Open questions at the time
    • Single-lab study
    • Direct link from Sema5A to ErbB2-DOCK7 activation not biochemically defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How DOCK7's distinct upstream inputs (RTK phosphorylation, scaffold recruitment, motor coupling) are integrated to direct context-specific Rac versus Cdc42 outputs and select among parallel cytoskeletal pathways remains unresolved.
  • No full-length structure linking regulatory inputs to the DHR2 catalytic cycle
  • No unified model for spatial partitioning between Rac-microtubule and Rho/MPRIP-actin outputs
  • Mechanism of nuclear/chromatin access for replication-stress role unclear

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Localization
GO:0005829 cytosol 2 GO:0005694 chromosome 1 GO:0005886 plasma membrane 1 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-162582 Signal Transduction 3 R-HSA-112316 Neuronal System 2 R-HSA-73894 DNA Repair 1
Partners
AGERERBB2ERBB4MDC1METMYO6NBEAL2TACC3

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 DOCK7 is a Rac GTPase activator that is asymmetrically distributed in unpolarized hippocampal neurons and selectively expressed in the nascent axon; DOCK7 knockdown prevents axon formation while overexpression induces multiple axons; DOCK7 and Rac activation lead to phosphorylation and inactivation of the microtubule destabilizing protein stathmin/Op18 in the nascent axon, establishing a DOCK7→Rac→stathmin/Op18 pathway for axon development. shRNA knockdown, overexpression, immunofluorescence localization, phospho-stathmin assays in hippocampal neurons Neuron High 16982419
2008 The NRG1 receptor ErbB2 directly binds and phosphorylates DOCK7 at Tyr-1118, activating DOCK7 GEF activity toward Rac1 and Cdc42, which in turn activates JNK to promote Schwann cell migration; a Y1118F mutant of DOCK7 fails to transduce NRG1 signals. Co-immunoprecipitation, site-directed mutagenesis (Y1118F), Rho GTPase pull-down activity assays, siRNA knockdown, Schwann cell migration assays The Journal of cell biology High 18426980
2011 DOCK7 negatively regulates Schwann cell differentiation and onset of myelination: DOCK7 knockdown shortens Rac/Cdc42/JNK activation (negative regulator of myelination) and accelerates Rho/ROCK activation (positive regulator of myelination), resulting in enhanced myelin thickness in Dock7 shRNA transgenic mice. siRNA knockdown in primary Schwann cells, shRNA transgenic mouse generation, Rho GTPase activity assays, myelin thickness measurement The Journal of neuroscience High 21880919
2012 DOCK7 interacts with the centrosome-associated protein TACC3 and antagonizes its microtubule growth-promoting function to control apically directed interkinetic nuclear migration of radial glial progenitor cells (RGCs), thereby regulating the switch from proliferative to differentiative divisions during cortical neurogenesis. In utero electroporation-based DOCK7 silencing/overexpression, co-immunoprecipitation of DOCK7 and TACC3, interkinetic nuclear migration assays, neuronal differentiation quantification Nature neuroscience High 22842144
2012 DOCK7 binds to the cytoplasmic domain of RAGE (receptor for advanced glycation end-products) via co-immunoprecipitation/MS, and transduces RAGE signaling to Cdc42, resulting in formation of dendritic pseudopodia and promoting cancer cell migration. Immunoprecipitation–LC-MS/MS screen of RAGE cytoplasmic domain interactors, co-immunoprecipitation validation, Cdc42 activity assay, DOCK7 knockdown with cell migration and morphology readouts Oncology reports Medium 23254359
2013 The DHR2 (GEF) domain of DOCK7 is a potent guanine nucleotide exchange factor for prenylated Cdc42 and Rac1 on membrane liposomes, but not for non-prenylated GTPases in solution; membrane localization of Cdc42/Rac1 is required for DOCK7-mediated activation. An N-terminal site within DHR2 (distinct from the catalytic active site) preferentially binds GTP-loaded Cdc42/Rac1 and recruits DHR2 to the membrane, creating positive cooperativity that accelerates nucleotide exchange. Liposome reconstitution assay, in vitro GEF activity assay with prenylated vs. non-prenylated GTPases, site-directed mutagenesis to identify GTPase-selectivity residues Biochemistry High 23718289
2014 DOCK7 functions as a cytoplasmic activator of the ErbB4 receptor tyrosine kinase in chandelier cells (ChCs); DOCK7 modulates ErbB4 activity and is required for chandelier cell cartridge and bouton development in vivo. In utero electroporation-based genetic labeling and manipulation of ChCs, DOCK7 knockdown/overexpression, co-immunoprecipitation of DOCK7 and ErbB4, morphological quantification of cartridges and boutons Cell reports Medium 24440718
2014 DOCK7 co-immunoprecipitates with c-Met in glioblastoma cells and this interaction is enhanced upon HGF stimulation in a manner dependent on the adaptor protein Gab1; Gab1 is required for HGF-induced DOCK7 and Rac1 activation and glioblastoma cell invasion. DOCK7 mediates serum- and HGF-induced GBM invasion via Rac activation. Co-immunoprecipitation (DOCK7 with c-Met, DOCK7 with Gab1), siRNA knockdown of DOCK7/Gab1, Rac1 GTPase activity assay, Matrigel and brain slice invasion assays British journal of cancer Medium 24518591
2009 Loss-of-function mutations in DOCK7 (misty and moonlight alleles) that truncate the DOCK7 protein cause generalized hypopigmentation and white-spotting in mice, demonstrating a non-redundant role for DOCK7 in dermal and follicular melanocyte distribution/function. Forward genetic mapping, allele complementation test, sequencing of DOCK7 mutations in misty and moonlight mice, phenotypic characterization Proceedings of the National Academy of Sciences of the United States of America High 19202056
2012 DOCK7 was identified as a binding partner of myosin VI (MVI) in neuronal PC12 cells by pull-down and mass spectrometry; endogenous MVI–DOCK7 interaction was confirmed by co-immunoprecipitation; the two proteins co-localize in interphase and dividing cells and in neurite outgrowths of primary hippocampal neurons. Pull-down + mass spectrometry, co-immunoprecipitation of endogenous proteins, co-localization by fluorescence microscopy Biochemistry and cell biology Medium 22475431
2016 Myosin VI (MVI) binds DOCK7 through its cargo domain RRL motif interacting with DOCK7 C-terminal M2 and DHR2 domains; MVI knockdown reduces Rac1 activity and decreases DOCK7 phosphorylation at Tyr1118, indicating that MVI contributes to DOCK7 activation; the MVI–DOCK7 interaction is required for NGF-stimulated protrusion formation in PC12 cells. Domain mapping by co-immunoprecipitation, MVI knockdown with Rac1 GTPase activity assay, pY1118-DOCK7 immunoblotting, NGF-stimulated differentiation assay, GFP-tagged cargo-domain dominant-negative overexpression Biochimica et biophysica acta Medium 27018747
2017 DOCK7 regulates postnatal neuroblast tangential migration along the rostral migratory stream via two distinct pathways: (1) a Rac-dependent pathway controlling leading process stability/growth likely through modulation of microtubule networks, and (2) a myosin phosphatase-RhoA-interacting protein (MYO9A/MPRIP)-dependent pathway regulating F-actin remodeling at the cell rear to promote somal translocation. In vivo DOCK7 knockdown by in utero electroporation, live imaging of neuroblast migration, F-actin and microtubule dynamics assays, Rac GTPase activity assays, dominant-negative pathway component expression The Journal of cell biology High 29089377
2017 DOCK7 interacts with NBEAL2 (the gray platelet syndrome protein) in megakaryocytes and platelets; GPS-causing mutations in the NBEAL2 BEACH domain disrupt NBEAL2–DOCK7 interaction; DOCK7 is localized on the membrane of or in α-granules; platelets from GPS patients and Nbeal2-deficient mice are almost devoid of DOCK7, resulting in defective actin polymerization, platelet activation, and shape change. Co-immunoprecipitation (reverse), proximity ligation assay, subcellular fractionation/localization, GPS patient platelet analysis, Nbeal2 KO mouse platelet functional assays Blood High 29187380
2021 DOCK7 acts as a replication stress regulator: it is phosphorylated by ATR kinase upon replication stress and recruited by MDC1 to chromatin and replication forks; DOCK7-mediated Rac1/Cdc42 activation leads to PAK1 activation, which phosphorylates RPA1 at S135 and T180 to stabilize chromatin-loaded RPA1 and ensure proper replication stress response; DOCK7 depletion sensitizes ovarian cancer cells to camptothecin. Chromatin fractionation, co-immunoprecipitation of DOCK7 with MDC1, phospho-site identification, Rac1/Cdc42 GTPase assays, PAK1 kinase assay, RPA1 phospho-mutant analysis, siRNA KD with camptothecin sensitivity assay Nucleic acids research High 33704464
2023 A planar-polarized MYO6–DOCK7 axis spatially restricts RAC1 activity in mammary epithelial monolayers to drive cryptic lamellipodia extension in follower cells, thereby promoting tissue fluidification and cooperative collective motion; MYO6 activity is required upstream of DOCK7 for this polarized RAC1 activation. Live imaging of lamellipodia in monolayers, MYO6/DOCK7 knockdown, RAC1 activity biosensor (FRET or localization assay), collective migration tracking Cell reports Medium 37590133
2025 The ErbB2–DOCK7 signaling axis mediates excessive neuronal process elongation induced by the ASD-linked Sema5A p.Arg676Cys variant; knockdown of DOCK7 or pharmacological inhibition of ErbB2 kinase reduces the aberrant process elongation and attenuates overactivation of downstream Rac1 and Cdc42 in primary cortical neurons and N1E-115 cells. shRNA knockdown of DOCK7, ErbB2 kinase inhibitor treatment, Rac1/Cdc42 GTPase activity assays, neuronal process length measurement in primary cortical neurons and N1E-115 cells International journal of molecular sciences Medium 41226692
2024 DOCK7 packaged in tumor-associated macrophage-derived extracellular vesicles (TAM-EVs) activates RAC1 in colorectal cancer (CRC) recipient cells, leading to AKT and FOXO1 phosphorylation and upregulation of ABCA1, which increases cholesterol efflux, membrane fluidity, and CRC cell motility/metastasis. EV isolation and LC-MS protein identification, siRNA knockdown of DOCK7 in TAM-EVs and CRC cells, RAC1 GTPase activity assay, AKT/FOXO1 phosphorylation immunoblotting, cholesterol efflux assay, Transwell migration and liver metastasis mouse model Clinical and translational medicine Medium 38385857

Source papers

Stage 0 corpus · 29 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18. Neuron 177 16982419
2008 ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration. The Journal of cell biology 113 18426980
2012 DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis. Nature neuroscience 81 22842144
2014 Regulation of chandelier cell cartridge and bouton development via DOCK7-mediated ErbB4 activation. Cell reports 43 24440718
2014 Mutations in DOCK7 in individuals with epileptic encephalopathy and cortical blindness. American journal of human genetics 41 24814191
2011 The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination. The Journal of neuroscience : the official journal of the Society for Neuroscience 41 21880919
2009 Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function. Proceedings of the National Academy of Sciences of the United States of America 36 19202056
2014 Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation. British journal of cancer 34 24518591
2012 DOCK7 is a critical regulator of the RAGE-Cdc42 signaling axis that induces formation of dendritic pseudopodia in human cancer cells. Oncology reports 34 23254359
2024 Tumour-associated macrophage-derived DOCK7-enriched extracellular vesicles drive tumour metastasis in colorectal cancer via the RAC1/ABCA1 axis. Clinical and translational medicine 33 38385857
2017 Nbeal2 interacts with Dock7, Sec16a, and Vac14. Blood 32 29187380
2013 Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7. Biochemistry 29 23718289
2016 Association between the DOCK7, PCSK9 and GALNT2 Gene Polymorphisms and Serum Lipid levels. Scientific reports 28 26744084
2012 Dock7: a GEF for Rho-family GTPases and a novel myosin VI-binding partner in neuronal PC12 cells. Biochemistry and cell biology = Biochimie et biologie cellulaire 27 22475431
2016 CRISPR/Cas9-Mediated Insertion of loxP Sites in the Mouse Dock7 Gene Provides an Effective Alternative to Use of Targeted Embryonic Stem Cells. G3 (Bethesda, Md.) 22 27175020
2015 Association of the variants and haplotypes in the DOCK7, PCSK9 and GALNT2 genes and the risk of hyperlipidaemia. Journal of cellular and molecular medicine 19 26493351
2017 Dual role for DOCK7 in tangential migration of interneuron precursors in the postnatal forebrain. The Journal of cell biology 18 29089377
2021 DOCK7 protects against replication stress by promoting RPA stability on chromatin. Nucleic acids research 17 33704464
2016 Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells. Biochimica et biophysica acta 17 27018747
2014 Oral administration of Nitraria retusa ethanolic extract enhances hepatic lipid metabolism in db/db mice model 'BKS.Cg-Dock7(m)+/+ Lepr(db/)J' through the modulation of lipogenesis-lipolysis balance. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 13 25086370
2017 Spontaneous mutation of Dock7 results in lower trabecular bone mass and impaired periosteal expansion in aged female Misty mice. Bone 12 28821457
2006 Nervous Rac: DOCK7 regulation of axon formation. Neuron 9 16982410
2023 A planar polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia. Cell reports 7 37590133
2021 Characteristic facial features and cortical blindness distinguish the DOCK7-related epileptic encephalopathy. Molecular genetics & genomic medicine 5 33471954
2022 Homozygosity for a Novel DOCK7 Variant Due to Segmental Uniparental Isodisomy of Chromosome 1 Associated with Early Infantile Epileptic Encephalopathy (EIEE) and Cortical Visual Impairment. International journal of molecular sciences 3 35806387
2023 The Interaction between the DOCK7 Protein and the E2 Protein of Classical Swine Fever Virus Is Not Involved with Viral Replication or Pathogenicity. Viruses 2 38257770
2026 Deletion of Dock7 Exons 3 and 4 Results in Reduced Trabecular Microarchitecture and a Decrease in Mineralization. bioRxiv : the preprint server for biology 1 41502932
2025 The ErbB2-Dock7 Signaling Axis Mediates Excessive Cell Morphogenesis Induced by Autism Spectrum Disorder- and Intellectual Disability-Associated Sema5A p.Arg676Cys. International journal of molecular sciences 0 41226692
2023 A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia. bioRxiv : the preprint server for biology 0 36747801

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