Affinage

DOCK3

Dedicator of cytokinesis protein 3 · UniProt Q8IZD9

Length
2030 aa
Mass
233.1 kDa
Annotated
2026-06-09
58 papers in source corpus 21 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

DOCK3 (MOCA) is a neuronally-enriched atypical guanine nucleotide exchange factor that drives Rac1 activation to control cytoskeletal remodeling, axon outgrowth, and neuroprotection (PMID:14718541, PMID:20368433). It binds Rac1 directly and enhances its GTPase loading through catalytic residues in the DHR-2 domain, concentrating at lamellipodial leading edges and growth cones and coupling Rac1 activation to JNK signaling (PMID:14718541, PMID:30976111). Downstream of BDNF-TrkB signaling, DOCK3 is recruited to the plasma membrane where it engages the WAVE complex via its DHR-1 domain and, after phosphorylation, dissociates to permit Rac1-driven axonal outgrowth (PMID:20368433); it forms a ternary complex with Elmo and activated RhoG that amplifies Rac1 activation, a node functionally validated by small molecules that stabilize the DOCK3-Elmo1 interaction and promote axon regeneration (PMID:22734669, PMID:37188749). In parallel, DOCK3 promotes microtubule assembly by inactivating GSK-3β to increase active CRMP-2, and by TrkB-dependent phosphorylation at Y562 that releases HAUS7 for transport to the growth cone (PMID:22219288, PMID:40712007). DOCK3 also confers neuroprotection by binding the C-terminal tails of NMDA receptor subunits NR2B and NR2D to reduce their surface expression and promote internalization, limiting excitotoxic retinal ganglion cell death (PMID:23852370, PMID:23641686, PMID:27615513). Independently, DOCK3 acts as a negative regulator of Wnt/β-catenin signaling by sequestering β-catenin at the membrane to suppress nuclear translocation and target-gene transcription (PMID:18716063). In skeletal muscle, DOCK3 interacts with SORBS1 through its C-terminal domain and is a dosage-sensitive regulator of glucose metabolism, myofiber regeneration, and myogenic differentiation, acting through RAC1/PI3K/AKT and PTEN/AKT signaling (PMID:24789910, PMID:32766788, PMID:37742307, PMID:36865261). Loss-of-function DOCK3 missense variants in the DHR-2 domain reduce Rac1 GEF activity and underlie a neurodevelopmental phenotype (PMID:30976111).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2004 High

    Established DOCK3 as a Rac1-binding activator, defining its core molecular activity and linking it to actin-based morphology in neurons.

    Evidence Co-IP, Rac1 GTPase pull-down, farnesylated membrane-targeted construct, and immunofluorescence in cortical neurons

    PMID:14718541

    Open questions at the time
    • DHR-2 catalytic mechanism not yet resolved at this stage
    • physiological upstream signal not defined
  2. 2008 High

    Identified a non-cytoskeletal role: DOCK3 negatively regulates Wnt/β-catenin signaling by retaining β-catenin at the membrane.

    Evidence cDNA library screen, co-IP, Wnt luciferase reporter, fractionation, and epistasis in human cells

    PMID:18716063

    Open questions at the time
    • domain mediating β-catenin binding not mapped
    • relationship to GEF activity unclear
  3. 2010 High

    Defined the BDNF-TrkB → DOCK3/WAVE membrane recruitment cascade and pinpointed DHR-2 catalytic residues, mechanistically grounding axon outgrowth.

    Evidence Domain mutagenesis, reciprocal co-IP, membrane fractionation, and in vivo optic nerve regeneration in Dock3 Tg mice

    PMID:20368433

    Open questions at the time
    • identity of the kinase phosphorylating DOCK3 not established here
    • stoichiometry of the DOCK3/WAVE complex unresolved
  4. 2012 High

    Extended DOCK3 function to microtubule control via GSK-3β inactivation/CRMP-2 and to Rac1 amplification through an Elmo/RhoG ternary complex.

    Evidence Co-IP, phosphorylation Western blots in hippocampal neurons, Rac1 pull-down, phospho-site mutagenesis, and neurite outgrowth in PC12 cells

    PMID:22219288 PMID:22734669

    Open questions at the time
    • how membrane recruitment, GSK-3β binding, and Elmo binding are temporally coordinated is unclear
    • direct kinase responsible for DOCK3 phosphorylation not identified
  5. 2012 Medium

    Placed DOCK3 as an integrator of Alzheimer-linked APP and presenilin death signals between Rac1/Cdc42 and ASK1.

    Evidence Cell death assays with AD mutant constructs and epistasis via MOCA overexpression/knockdown in neuronal cells

    PMID:22115042

    Open questions at the time
    • mechanistic placement inferred from epistasis, not direct biochemistry
    • physiological relevance in vivo not tested
    • single lab
  6. 2013 High

    Defined a neuroprotective mechanism: DOCK3 binds NR2B and NR2D C-termini to lower NMDA receptor surface levels and limit excitotoxic RGC death.

    Evidence Co-IP of DOCK3 with NR2B/NR2D C-termini, surface expression assays, and quantitative RGC counts in Dock3 Tg, GLAST-KO, and NR2D-KO mice

    PMID:23641686 PMID:23852370

    Open questions at the time
    • mechanism of receptor internalization not resolved at this stage
    • whether GEF activity is required for receptor regulation untested
  7. 2014 High

    Revealed DOCK3 as a miR-486 target in skeletal muscle that modulates PTEN/AKT signaling and apoptosis, opening a non-neuronal role.

    Evidence 3'UTR luciferase validation, DOCK3 overexpression in human myotubes, PTEN/pAKT Western blots, and miR-486 transgenic mice on DMD background

    PMID:24789910

    Open questions at the time
    • direct biochemical link between DOCK3 and PTEN/AKT not established
    • GEF dependence of the muscle phenotype unclear
  8. 2014 Medium

    Showed DOCK3 protects myelin via increased ERK activation in a demyelination model, extending its protective role to oligodendrocytes.

    Evidence Cuprizone demyelination in Dock3 Tg mice, immunohistochemistry, electroretinogram, and pErk Western blot

    PMID:25165881

    Open questions at the time
    • how DOCK3 couples to ERK not defined
    • single lab, overexpression-based
  9. 2015 Medium

    Implicated DOCK3 in pathological Rac1 activity in both cancer cell invasion and epileptogenesis.

    Evidence miR-512-3p/siRNA knockdown with active RAC1 pull-down and migration/invasion in NSCLC lines; Dock3 shRNA with Rac1-GTP and seizure scoring in mouse kindling models

    PMID:25687035 PMID:26319681

    Open questions at the time
    • direct partners in these contexts not mapped
    • single lab per context
  10. 2016 Medium

    Linked DOCK3-mediated β-catenin suppression to WAVE2 expression and lamellipodial/tumor cell motility, and proposed Fyn inhibition as the route to NMDA receptor internalization.

    Evidence Co-IP, in vitro kinase assays, knockdown with migration readouts; in vivo Dock3 Tg with NMDA receptor and Fyn activity measurements

    PMID:26716413 PMID:27615513

    Open questions at the time
    • Fyn-mediated internalization mechanism is suggested, not directly proven
    • single lab studies
  11. 2019 Medium

    Connected DOCK3 to human disease by showing DHR-2 missense variants reduce Rac1 GEF activity, establishing loss-of-function as the basis of a neurodevelopmental phenotype.

    Evidence Patient-variant mutagenesis with active Rac1 pull-down and structural modeling

    PMID:30976111

    Open questions at the time
    • limited patient numbers
    • in vivo consequence of variants not modeled
    • single lab
  12. 2020 Medium

    Defined DOCK3 as a dosage-sensitive regulator of muscle, where haploinsufficiency benefits but complete loss worsens dystrophic muscle and impairs myogenic differentiation.

    Evidence Dock3 KO crossed with mdx mice, muscle function tests, myoblast differentiation, and RNA-seq

    PMID:32766788

    Open questions at the time
    • molecular basis of the dosage sensitivity unresolved
    • single lab
  13. 2023 High

    Established a distinct muscle-metabolic role through SORBS1 binding and identified ZBED6 as a direct transcriptional repressor acting via RAC1/PI3K/AKT.

    Evidence Muscle-specific Dock3 conditional KO with metabolic phenotyping and DOCK3-SORBS1 co-IP; ChIP-seq/RNA-seq and CLP sepsis model in ZBED6-deficient pigs

    PMID:36865261 PMID:37551034 PMID:37742307

    Open questions at the time
    • how SORBS1 binding feeds into glucose metabolism mechanistically is unresolved
    • whether GEF activity is required for the metabolic role untested
  14. 2023 Medium

    Validated the DOCK3-Elmo1 interaction as a druggable functional node for Rac1-driven axon regeneration.

    Evidence High-throughput compound screen, DOCK3-Elmo1 interaction assay, neurite outgrowth, and in vivo optic nerve crush

    PMID:37188749

    Open questions at the time
    • binding site of compounds not defined
    • single lab
  15. 2025 High

    Identified HAUS7 as a DOCK3-controlled cargo whose TrkB/Y562-phosphorylation-dependent release from DOCK3 enables microtubule assembly and axon regeneration.

    Evidence Reciprocal co-IP, Y562 phospho-site mutagenesis, live imaging of HAUS7 transport, and Haus7 conditional KO with optic nerve crush

    PMID:40712007

    Open questions at the time
    • kinase directly phosphorylating Y562 not identified
    • relationship between HAUS7 transport and the WAVE/Elmo modules unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How DOCK3's multiple binding modules (WAVE, Elmo/RhoG, GSK-3β, HAUS7, NMDA receptors, β-catenin, SORBS1) are spatially and temporally coordinated downstream of a single phosphorylation switch remains unresolved.
  • no integrated structural or temporal model of DOCK3 complex switching
  • identity of the DOCK3 kinase(s) not established
  • whether neuronal and muscle functions share a common biochemical mechanism unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0060089 molecular transducer activity 3 GO:0060090 molecular adaptor activity 3
Localization
GO:0005886 plasma membrane 4 GO:0005829 cytosol 1 GO:0005856 cytoskeleton 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-112316 Neuronal System 3 R-HSA-1266738 Developmental Biology 3 R-HSA-397014 Muscle contraction 3
Partners
CTNNB1ELMO1GRIN2BGSK3BRAC1RHOGSORBS1WAVE1

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 MOCA/DOCK3 binds directly to Rac1 and enhances its GTPase activity, leading to activation of c-Jun N-terminal kinase (JNK) and changes in cell morphology. Farnesylated MOCA localized to the plasma membrane showed enhanced Rac1 and JNK activation. Endogenous MOCA concentrates at lamellipodia leading edges and growth cones co-localized with actin filaments. Co-immunoprecipitation, GTPase activity assay (Rac1 pull-down), overexpression of farnesylated vs. wild-type MOCA, immunofluorescence in cortical neurons The Journal of biological chemistry High 14718541
2010 DOCK3 directly associates with WAVE proteins through its DHR-1 domain. BDNF-TrkB signaling recruits the DOCK3/WAVE1 complex to the plasma membrane, whereupon DOCK3 activates Rac1 and dissociates from the WAVE complex in a phosphorylation-dependent manner, driving axonal outgrowth. Key conserved amino acids in the DHR-2 domain are critical for catalytic GEF activity of DOCK3. Co-immunoprecipitation, DHR-1/DHR-2 domain mutagenesis, membrane fractionation, in vivo optic nerve regeneration in Dock3 transgenic mice, neurite outgrowth assay Proceedings of the National Academy of Sciences of the United States of America High 20368433
2012 DOCK3 binds to and inactivates GSK-3β at the plasma membrane, increasing the non-phosphorylated active form of CRMP-2, which promotes microtubule assembly and axon branching. BDNF induced GSK-3β phosphorylation and CRMP-2 dephosphorylation in hippocampal neurons, and elevated GSK-3β phosphorylation was detected in regenerating axons of Dock3 transgenic mice after optic nerve injury. Co-immunoprecipitation, phosphorylation assays (Western blot), primary hippocampal neuron culture, in vivo optic nerve crush in Dock3 Tg mice The Journal of neuroscience High 22219288
2012 DOCK3 forms a ternary complex with Elmo and activated RhoG downstream of BDNF-TrkB signaling to induce neurite outgrowth via Rac1 activation in PC12 cells. Phosphorylation of DOCK3 and its interaction with Elmo are both required for efficient Rac1 activation; membrane recruitment of DOCK3 is also necessary. Co-immunoprecipitation, Rac1 pull-down (active GTP-bound Rac1 assay), neurite outgrowth assay in PC12 cells, site-directed mutagenesis of phosphorylation sites Genes to cells High 22734669
2013 DOCK3 directly binds to the intracellular C-terminus domain of NR2B (GluN2B), an NMDA receptor subunit. Overexpression of DOCK3 in transgenic mice decreased NR2B expression in the retina and ameliorated NMDA-induced retinal degeneration. DOCK3 overexpression also suppressed phosphorylation of NR2B in GLAST-KO mice, reducing excitotoxic and oxidative stress-related RGC death. Co-immunoprecipitation (DOCK3 and NR2B C-terminus), Western blot, in vivo retinal degeneration assay in Dock3 Tg and GLAST KO mice, NMDA injection model Cell death and differentiation High 23852370
2013 DOCK3 binds to the NR2D C-terminal domain and reduces surface expression of NR2D, thereby protecting retinal ganglion cells from excitotoxicity. NR2D deficiency also attenuates RGC loss in GLAST-deficient mice. Co-immunoprecipitation (DOCK3 and NR2D C-terminus), surface expression assay, genetic mouse models (NR2D KO × GLAST KO), RGC counting Molecular brain High 23641686
2008 MOCA/DOCK3 functions as a negative regulator of Wnt/β-catenin signaling. MOCA forms a complex with β-catenin and inhibits transcription of Wnt target genes, reduces nuclear β-catenin levels, increases membrane-bound β-catenin levels, and enhances cell-cell adhesion. Epistasis experiments placed MOCA action at the level of reducing nuclear β-catenin. Functional cDNA library screen in human cells, co-immunoprecipitation (MOCA and β-catenin), Wnt target gene luciferase reporter assay, subcellular fractionation, cell-cell adhesion assay Molecular biology of the cell High 18716063
2012 MOCA/DOCK3 is a downstream integrator of neuronal death signals from both familial AD-linked APP mutants and presenilin (PS1/PS2) mutants, in a γ-secretase-independent manner. MOCA links PS-mediated death signals with APP-mediated death signals at a point between Rac1/Cdc42 and ASK1 (apoptosis signal-regulating kinase 1). Cell death assays with AD mutant constructs (APP, PS1, PS2), epistasis analysis using MOCA overexpression/knockdown, genetic interaction experiments in neuronal cells The Biochemical journal Medium 22115042
2014 DOCK3 is a direct target of miR-486 in skeletal muscle. Overexpression of DOCK3 in human myotubes modulates PTEN/AKT signaling (increases PTEN and reduces phosphorylated AKT) and induces apoptosis. In dystrophic mice, miR-486 overexpression decreases DOCK3 levels, reduces PTEN expression, and increases phospho-AKT. miR-486 target validation (3'UTR luciferase), DOCK3 overexpression in human myotubes, Western blot for PTEN/pAKT, in vivo miR-486 transgenic mice on DMD background The Journal of clinical investigation High 24789910
2015 DOCK3, as a RAC1-GEF, is a target of miR-512-3p in NSCLC cells. Knockdown of DOCK3 inhibited cell adhesion, migration, and invasion, and decreased active RAC1 levels, demonstrating that DOCK3 promotes RAC1 activity and metastatic behaviors in lung cancer cells. miR-512-3p overexpression, DOCK3 siRNA knockdown, active RAC1 pull-down assay, cell migration/invasion assays in A549 and H1299 cell lines The international journal of biochemistry & cell biology Medium 25687035
2016 DOCK3 acts as a negative regulator of WAVE2 expression by blocking β-catenin nuclear translocation; phospho-Annexin A2 (pY23) promotes DOCK3 expression, and DOCK3 inhibits lamellipodium dynamics and tumor cell movement via suppression of β-catenin/WAVE2 signaling axis. Co-immunoprecipitation, in vitro kinase assay (Src/CD147/Annexin A2), DOCK3 knockdown, Western blot, cell migration assay, β-catenin subcellular localization Oncotarget Medium 26716413
2014 DOCK3 is expressed in oligodendrocytes, and Dock3 overexpression protects myelin in the corpus callosum and optic nerves in a cuprizone-induced demyelination model. In Dock3 Tg mice, Erk activation is increased, suggesting ERK signaling as part of the Dock3-mediated protective mechanism. Immunohistochemistry for oligodendrocyte markers, cuprizone demyelination model in Dock3 Tg mice, multifocal electroretinogram, Western blot (pErk) Cell death & disease Medium 25165881
2015 Dock3 expression increases in epileptic brain tissue and models, and Dock3 shRNA knockdown reduces Rac1-GTP levels, decreases severity of status epilepticus, reduces spontaneous recurrent seizures, and increases latency in a kindling model, placing Dock3 upstream of Rac1 in epileptogenesis. shRNA knockdown of Dock3 in lithium-pilocarpine and pentylenetetrazole kindling mouse models, active Rac1 pull-down, behavioral seizure scoring Molecular neurobiology Medium 26319681
2019 DOCK3 missense variants in or adjacent to the DHR-2 domain significantly reduce Rac1 GEF activity compared to wild-type DOCK3, confirming that the DHR-2 domain is critical for Rac1 activation and that loss-of-function of this activity underlies the neurodevelopmental phenotype. Site-directed mutagenesis of patient missense variants, Rac1 pull-down (active GTP-bound Rac1) assay in transfected cells, protein structural modeling European journal of human genetics Medium 30976111
2020 DOCK3 is a dosage-sensitive modulator of skeletal muscle function. Haploinsufficiency of Dock3 in DMD mice improved dystrophic muscle pathologies, but complete knockout worsened muscle function. Dock3 KO myoblasts are defective in myogenic differentiation, with transcriptomic analyses revealing decreased myogenic factors. Dock3 global knockout mice crossed with mdx dystrophic mice, muscle function tests, myoblast differentiation assays, RNA-seq transcriptomics Human molecular genetics Medium 32766788
2023 DOCK3 directly interacts with SORBS1 through its C-terminal domain in skeletal muscle. Conditional muscle-specific Dock3 knockout (mKO) mice display hyperglycemia, increased fat mass, impaired myofiber regeneration, and metabolic dysfunction, establishing a role for DOCK3 in skeletal muscle glucose metabolism and regeneration distinct from its neuronal functions. Dock3 conditional skeletal muscle-specific knockout mice, co-immunoprecipitation (DOCK3 and SORBS1), metabolic phenotyping, muscle histology, locomotor activity assays FASEB journal High 36865261 37742307
2023 ZBED6 transcription factor directly represses DOCK3 expression (ChIP-seq and RNA-seq), and in ZBED6-deficient septic pigs, increased DOCK3 expression activates the RAC1/PI3K/AKT pathway, protecting against sepsis-induced muscle wasting. ChIP-seq and RNA-seq in ZBED6-deficient pigs, Western blot (DOCK3, RAC1-GTP, pAKT), CLP sepsis pig model, ZBED6 overexpression in myotubes Advanced science Medium 37551034
2023 Low-molecular-weight compounds that stimulate the interaction between DOCK3 and Elmo1 promote neurite outgrowth in vitro and neuroprotection/axon regeneration in a mouse optic nerve injury model, confirming that the DOCK3-Elmo1 interaction is a functional node for Rac1 activation and axon elongation. High-throughput compound screen (462,169 compounds), DOCK3-Elmo1 interaction assay, neurite outgrowth assay, in vivo optic nerve crush model Cell death discovery Medium 37188749
2025 HAUS7 (HAUS augmin-like complex subunit 7) is a direct binding partner of DOCK3. Neuronal HAUS7 is transported from the cell body to the growth cone under control of DOCK3. Phosphorylation of DOCK3 at Y562 by TrkB signaling causes dissociation of HAUS7, which is required for microtubule assembly and axon regeneration. Deletion of Haus7 significantly reduced microtubule formation and axon regeneration after optic nerve crush. Co-immunoprecipitation (DOCK3-HAUS7), phospho-specific mutagenesis (Y562), live imaging of HAUS7 transport, Haus7 conditional knockout mice with optic nerve crush, transcriptome analysis Science advances High 40712007
2016 Dock3 overexpression promotes internalization and degradation of NMDA receptors in the retina in vivo. This process is suggested to be mediated by inhibition of Fyn (a Src family tyrosine kinase), reducing excitotoxic damage and oxidative stress, thereby promoting RGC survival. In vivo Dock3 Tg mice with optic nerve crush or NMDA stimulation, Western blot for NMDA receptor subunit levels and Fyn activity, retinal ganglion cell survival counts Histology and histopathology Medium 27615513

Source papers

Stage 0 corpus · 58 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Incremental value of biomarkers to clinical variables for mortality prediction in acutely decompensated heart failure: the Multinational Observational Cohort on Acute Heart Failure (MOCA) study. International journal of cardiology 188 23538053
2014 MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms. The Journal of clinical investigation 126 24789910
2003 Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype. Journal of medical genetics 102 14569117
2004 MOCA induces membrane spreading by activating Rac1. The Journal of biological chemistry 80 14718541
1978 Urinary bladder tumors in dogs from 4,4'-methylene-bis (2-chloroaniline) (MOCA). Journal of environmental pathology and toxicology 75 722185
2010 Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proceedings of the National Academy of Sciences of the United States of America 74 20368433
2012 Dock3 stimulates axonal outgrowth via GSK-3β-mediated microtubule assembly. The Journal of neuroscience : the official journal of the Society for Neuroscience 73 22219288
2013 Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma. Cell death and differentiation 69 23852370
2009 MocA is a specific cytidylyltransferase involved in molybdopterin cytosine dinucleotide biosynthesis in Escherichia coli. The Journal of biological chemistry 46 19542235
2013 Dock3 interaction with a glutamate-receptor NR2D subunit protects neurons from excitotoxicity. Molecular brain 44 23641686
2015 Inhibition of RAC1-GEF DOCK3 by miR-512-3p contributes to suppression of metastasis in non-small cell lung cancer. The international journal of biochemistry & cell biology 39 25687035
2016 Structural and functional features of the NAD(P) dependent Gfo/Idh/MocA protein family oxidoreductases. Protein science : a publication of the Protein Society 35 26749496
2016 CD147 regulates cancer migration via direct interaction with Annexin A2 and DOCK3-β-catenin-WAVE2 signaling. Oncotarget 34 26716413
2012 Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG. Genes to cells : devoted to molecular & cellular mechanisms 26 22734669
2016 Effect of ultrasound on the supercritical CO2 extraction of bioactive compounds from dedo de moça pepper (Capsicum baccatum L. var. pendulum). Ultrasonics sonochemistry 24 26964951
1990 Quantification of haemoglobin binding of 4,4'-methylenebis(2-chloroaniline) (MOCA) in rats. Archives of toxicology 23 1703404
1990 4,4'-Methylene-bis(2-chloroaniline) (MOCA): comparison of macromolecular adduct formation after oral or dermal administration in the rat. Fundamental and applied toxicology : official journal of the Society of Toxicology 23 2318352
1988 Metabolism of 4,4'-methylene-bis-2-chloroaniline (MOCA) by rats in vivo and formation of N-hydroxy MOCA by rat and human liver microsomes. Carcinogenesis 23 3365833
2014 Dock3 protects myelin in the cuprizone model for demyelination. Cell death & disease 22 25165881
2023 Loss of ZBED6 Protects Against Sepsis-Induced Muscle Atrophy by Upregulating DOCK3-Mediated RAC1/PI3K/AKT Signaling Pathway in Pigs. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 21 37551034
2017 Biallelic loss-of-function variants in DOCK3 cause muscle hypotonia, ataxia, and intellectual disability. Clinical genetics 21 28195318
2016 Neuropsychological screening tools in Italian HIV+ patients: a comparison of Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE). The Clinical neuropsychologist 21 27180611
2015 Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models. Molecular neurobiology 19 26319681
2008 A novel functional screen in human cells identifies MOCA as a negative regulator of Wnt signaling. Molecular biology of the cell 19 18716063
2005 Differential induction of micronuclei in peripheral lymphocytes and exfoliated urothelial cells of workers exposed to 4,4'-methylenebis-(2-chloroaniline) (MOCA) and bitumen fumes. Reviews on environmental health 19 16335575
2012 MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins. The Biochemical journal 18 22115042
2017 DOCK3-related neurodevelopmental syndrome: Biallelic intragenic deletion of DOCK3 in a boy with developmental delay and hypotonia. American journal of medical genetics. Part A 16 29130632
2019 Variants in DOCK3 cause developmental delay and hypotonia. European journal of human genetics : EJHG 15 30976111
2023 CircRNA hsa_circ_0006859 inhibits the osteogenic differentiation of BMSCs and aggravates osteoporosis by targeting miR-642b-5p/miR-483-3p and upregulating EFNA2/DOCK3. International immunopharmacology 14 36764273
2002 Identification and characterization of Moca-cyp. A Drosophila melanogaster nuclear cyclophilin. The Journal of biological chemistry 14 12154086
2013 Microbe observation and cultivation array (MOCA) for cultivating and analyzing environmental microbiota. Microbiome 13 24468000
2009 Mobile Care (Moca) for Remote Diagnosis and Screening. Journal of health informatics in developing countries 13 21822397
2020 Correlation of changes in serum S100β, NSE and inflammatory factor levels with MMSE and MoCA in intracranial tumor patients with cognitive impairment. Oncology letters 12 32724442
2020 DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologies. Human molecular genetics 12 32766788
2016 Dock3-NMDA receptor interaction as a target for glaucoma therapy. Histology and histopathology 12 27615513
2014 Dock3 overexpression and p38 MAPK inhibition synergistically stimulate neuroprotection and axon regeneration after optic nerve injury. Neuroscience letters 12 25172145
1987 DNA binding of 4,4'-methylene-bis(2-chloroaniline) (MOCA) in explant cultures of human and dog bladder. Cancer letters 9 3690513
2023 DOCK3 regulates normal skeletal muscle regeneration and glucose metabolism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 8 37742307
2021 Role of MT1A Polymorphism and Environmental Mercury Exposure on the Montreal Cognitive Assessment (MoCA). Neuropsychiatric disease and treatment 8 34326641
2024 Exploratory biomarker analysis in the phase III L-MOCA study of olaparib maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer. BMC medicine 6 38755585
2023 Neuroprotection and axon regeneration by novel low-molecular-weight compounds through the modification of DOCK3 conformation. Cell death discovery 6 37188749
2019 The Relation of Brain-Derived Neurotropic Factor (BDNF) Serum Level to Sub-Domain Cognitive Functions of Indonesian Schizophrenia Patients Measured by MoCA-Ina. Open access Macedonian journal of medical sciences 6 32165951
1998 Mutagenicity of N-OH-MOCA (4-amino-4'-hydroxylamino-bis-3,3'-dichlorodiphenylmethane) and PBQ (2-phenyl-1,4-benzoquinone) in human lymphoblastoid cells. Toxicology letters 4 9704822
1997 In vitro effects of MOCA and dapsone on rat hepatic and splenic immune cells. Immunopharmacology 4 9043931
2025 ICAM-1 and IL-10 are associated with cognitive dysfunction using the MoCA test in glioma: Findings from the NCI Neuro-Oncology Branch Natural History Study. Neuro-oncology advances 2 40041201
2023 DOCK3-Associated Neurodevelopmental Disorder-Clinical Features and Molecular Basis. Genes 2 37895289
2025 Targeted ErbB4 receptor activation ameliorates neuronal deficits via DOCK3 signaling in a transgenic mouse AD model. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 1 40940223
2023 DOCK3 regulates normal skeletal muscle regeneration and glucose metabolism. bioRxiv : the preprint server for biology 1 36865261
2023 Correlation between the Cognitive Status (SIRT1) and the Metabolic Function in Geriatric Patients Using the Indonesian Version of the Montreal Cognitive Assessment (MoCA-INA). Geriatrics (Basel, Switzerland) 1 38132490
2026 Real-world evidence from 50,000 online participants using MoCA-XpressO for cognitive prescreening. Scientific reports 0 41530426
2026 Association of MOCA Cognitive Domains and Serum Biomarkers With Anxiety Disorders in Elderly Men With Cognitive Impairment: A Cross-Sectional Analysis. Revista de neurologia 0 42052788
2026 Diagnostic accuracy of IHDS and MoCA in screening for HIV-associated neurocognitive disorders among adults living with HIV in Ethiopia. International journal of mental health systems 0 42087218
2026 CB-Dock3: an enhanced web server for protein-ligand blind docking. Nucleic acids research 0 42087554
2026 Orexinergic Dysregulation in Major Depressive Disorder: Insights from a Prospective Cohort Study Evaluating MADRS, PSQI, and MoCA Scores. Indian journal of psychological medicine 0 42205883
2025 Research-Based Whole Genome Sequencing Identifies Biallelic Loss of Function Variants in DOCK3 Gene Causing DOCK3-Related Disorder: The End of a Diagnostic Journey for This Family. Clinical genetics 0 40151040
2025 Role of HAUS7 as a DOCK3 binding partner in facilitating axon regeneration. Science advances 0 40712007
2025 DOCK3 orchestrates metastasis and immune microenvironment in prostate cancer. Frontiers in urology 0 41200217
2024 Characters of the MOCA family in wheat and TaMOCA1 function in salt stress tolerance. Journal of genetics 0 38379229

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