Affinage

Showing C1QTNF3 — CTRP3 is a alias.

C1QTNF3

Complement C1q tumor necrosis factor-related protein 3 · UniProt Q9BXJ4

Length
246 aa
Mass
27.0 kDa
Annotated
2026-06-09
100 papers in source corpus 40 papers cited in narrative 41 extracted findings
Cross-family judge faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

C1QTNF3 (CTRP3/cartducin/cartonectin) is a secreted adipokine that circulates as trimers and alternatively spliced hetero-oligomers, the latter association protecting the longer isoform from proteolytic cleavage (PMID:20952387, PMID:16213490). It functions broadly as a metabolic and anti-inflammatory cytoprotective factor: in liver it lowers glucose output by activating Akt and suppressing gluconeogenic gene expression independently of insulin (PMID:20952387), and it limits hepatic steatosis by downregulating triglyceride-synthesis enzymes (GPAT, AGPAT, DGAT) and promoting fatty acid oxidation (PMID:23744740, PMID:29763374). Across cardiac, intestinal, pancreatic, reproductive, and neuronal tissues, CTRP3 confers protection chiefly through an AMPK/SIRT1–PGC-1α axis that drives mitochondrial biogenesis and the mitochondrial unfolded protein response via SIRT1/ATF5, while SIRT1 also restrains NF-κB inflammatory signaling (PMID:27793739, PMID:36592863, PMID:38278820, PMID:29572383, PMID:33098065). In fibrotic and hypertrophic settings it activates AMPK and Akt and blocks TGF-β1–driven Smad3 phosphorylation and Smad3–p300 interaction (PMID:26138247). Genetic loss-of-function establishes CTRP3 as a negative regulator of autoimmune and inflammatory disease, increasing severity of collagen-induced arthritis and colitis and augmenting Th17 differentiation, the latter acting through AdipoR2 to lower Rorc and Stat3 (PMID:24269820, PMID:34925309, PMID:36592863). CTRP3 binds cell-surface LAMP1, a confirmed receptor identified by ligand-receptor capture and Co-IP, which transduces anti-inflammatory STAT3 suppression in keratinocytes and a LAMP1/JIP2/JNK cardioprotective signal (PMID:27727322, PMID:34687744, PMID:35278832). Its actions are context-dependent and not uniformly protective: CTRP3 exacerbates tendinopathy by driving chondrogenic differentiation of tendon progenitors via Akt and promotes macrophage chemotaxis and M1 polarization in adipose tissue (PMID:34797714, PMID:35720277). Notably, genetic deletion has minimal impact on whole-body glucose metabolism, contrasting with gain-of-function studies and revealing route- and model-dependent effects (PMID:26670485, PMID:26997632).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2005 Medium

    Established the first functional readout for the secreted protein by showing it assembles into trimers and acts as an anti-inflammatory factor on monocytes.

    Evidence Baculovirus-expressed CTRP3 trimer characterization with cytokine ELISA and NF-κB reporter in monocytic cells

    PMID:16213490

    Open questions at the time
    • No receptor identified
    • NF-κB suppression inferred from reporter, not endogenous pathway
    • No in vivo confirmation
  2. 2007 Medium

    Defined an early mitogenic role and its MAPK basis, showing CTRP3 drives endothelial proliferation and migration through ERK1/2 and p38.

    Evidence Recombinant CTRP3 on endothelial cells with U0126 and SB203580 inhibitor dissection

    PMID:17534697

    Open questions at the time
    • No receptor linking CTRP3 to MAPK activation
    • Single cell line
    • Physiological relevance to vasculature untested
  3. 2010 High

    Identified the metabolic core function — insulin-independent suppression of hepatic gluconeogenesis via Akt — and the isoform biology of circulating CTRP3.

    Evidence In vivo recombinant administration in ob/ob mice with hepatocyte gluconeogenic gene analysis; biochemical isoform hetero-oligomerization and protease protection

    PMID:20952387

    Open questions at the time
    • Receptor mediating hepatic Akt activation unknown
    • Mechanism linking oligomer state to function unclear
  4. 2013 High

    Extended the hepatic role from glucose to lipid handling, showing CTRP3 reduces steatosis by suppressing triglyceride-synthesis enzymes.

    Evidence Transgenic overexpression on high-fat diet plus recombinant treatment of H4IIE hepatocytes with lipogenic enzyme qPCR

    PMID:23744740

    Open questions at the time
    • Signaling pathway controlling lipogenic enzyme downregulation not defined
    • Receptor not addressed
  5. 2013 High

    Provided genetic loss-of-function proof that CTRP3 is a negative regulator of autoimmune arthritis.

    Evidence C1qtnf3 knockout mice in collagen-induced arthritis with histology, autoantibody, and cytokine readouts

    PMID:24269820

    Open questions at the time
    • Cellular target of the anti-inflammatory effect not identified
    • No mechanistic pathway in this model
  6. 2015 High

    Resolved the anti-fibrotic mechanism, placing CTRP3 upstream of TGF-β1/Smad3 signaling via AMPK and Akt.

    Evidence Adenoviral CTRP3 in post-MI rats with cardiac fibroblast Co-IP for Smad3-p300 and AMPK inhibitor AraA

    PMID:26138247

    Open questions at the time
    • How CTRP3 activates AMPK upstream not defined
    • Receptor not identified
  7. 2015 High

    Defined CTRP3 as a brake on osteoclastogenesis through the AMPK–c-Fos–NFATc1 axis, linking it to bone homeostasis.

    Evidence Recombinant CTRP3 on bone marrow macrophages with signaling Western blot and calvarial bone in vivo model

    PMID:26103094

    Open questions at the time
    • Receptor coupling to AMPK in osteoclast precursors unknown
  8. 2015 High

    Challenged the gain-of-function metabolic model by showing genetic deletion has minimal effect on glucose metabolism, revealing model-dependence.

    Evidence Ctrp3-KO mice with hyperinsulinemic-euglycemic clamp and liver phenotyping

    PMID:26670485

    Open questions at the time
    • Reasons for discrepancy with recombinant/transgenic studies unresolved
    • Possible compensation by paralogs not tested
  9. 2016 Medium

    Identified the first candidate cell-surface receptors (LAMP1 and LIMP II) for CTRP3, addressing the long-standing receptor gap.

    Evidence LRC-TriCEPS ligand-receptor capture with confirmatory Co-IP and antibody blocking on hepatoma cells

    PMID:27727322

    Open questions at the time
    • LAMP1 as a signaling receptor not demonstrated here
    • LIMP II association not functionally validated
    • Single lab, novel technology
  10. 2016 High

    Established the AMPK/SIRT1–PGC-1α axis as the mechanism by which CTRP3 promotes mitochondrial biogenesis.

    Evidence Globular CTRP3 on ventricular myocytes with AMPK/Sirt1 inhibitors, PGC-1α siRNA, and TEM/OCR/mtDNA readouts

    PMID:27793739

    Open questions at the time
    • Receptor upstream of AMPK not identified
    • Generalizability across cell types established only later
  11. 2017 High

    Refined cardioprotective signaling by placing AMPKα downstream of a cAMP-EPAC-MEK cascade and demonstrating SIRT1 dependence against drug-induced injury.

    Evidence AAV CTRP3 in diabetic and doxorubicin-treated rodent hearts with AMPKα and Sirt1 genetic/pharmacological loss-of-function

    PMID:28258411 PMID:29061338

    Open questions at the time
    • How CTRP3 engages cAMP generation at the membrane unknown
    • Receptor link to cAMP-EPAC-MEK not established
  12. 2021 High

    Identified AdipoR2 as the receptor for CTRP3's suppression of Th17 differentiation, providing a defined receptor-to-transcription-factor pathway.

    Evidence C1qtnf3-KO mice and EAE model with AdipoR1/R2 antagonist dissection and Rorc/Stat3 qPCR

    PMID:34925309

    Open questions at the time
    • Direct AdipoR2-CTRP3 binding not shown biochemically
    • Relationship between AdipoR2 and LAMP1 signaling unclear
  13. 2022 Medium

    Demonstrated LAMP1 functions as a signaling receptor, transducing CTRP3 anti-inflammatory STAT3 suppression and a cardioprotective JIP2/JNK signal.

    Evidence Co-IP of CTRP3-LAMP1 and LAMP1-JIP2 with STAT3 and JNK pathway dissection in keratinocyte and cardiac I/R models

    PMID:34687744 PMID:35278832

    Open questions at the time
    • LAMP1 as canonical lysosomal protein acting as surface receptor mechanistically unusual and not fully resolved
    • Single Co-IP-based validation per study
  14. 2022 High

    Generalized the SIRT1 mechanism across inflammatory tissues and extended it to the mitochondrial UPR via SIRT1/ATF5 in cardiac hypertrophy.

    Evidence Dual KO/transgenic colitis and TAC models with organoid and ATF5/SIRT1 epistasis and pharmacological SIRT1 modulation

    PMID:36592863 PMID:38278820

    Open questions at the time
    • Receptor coupling CTRP3 to SIRT1 induction not defined
    • Tissue-specific selectivity of effects unexplained
  15. 2022 High

    Revealed context-dependent and detrimental roles, with CTRP3 driving chondrogenic tendon degeneration and adipose macrophage recruitment.

    Evidence Gain/loss-of-function and neutralizing antibody mouse models for tendinopathy and tumor-associated adipose tissue with Akt/ERK pathway analysis

    PMID:34797714 PMID:35720277

    Open questions at the time
    • Why CTRP3 is protective in some tissues but pathogenic in others not mechanistically reconciled
    • Receptor mediating pro-pathogenic Akt activation unknown
  16. 2022 Medium

    Mapped transcriptional control of CTRP3, showing FOXO4 directly represses its promoter under high glucose.

    Evidence ChIP and luciferase reporter for FOXO4 binding plus siRNA epistasis on Nrf2/NF-κB in retinal pericytes

    PMID:35196182

    Open questions at the time
    • Other transcriptional regulators in non-pericyte tissues not addressed
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CTRP3's distinct receptors (LAMP1, AdipoR2, LIMP II) coordinate to produce its divergent tissue-specific and sometimes opposing outcomes remains unresolved.
  • No unified receptor-to-effector model integrating LAMP1, AdipoR2, and the AMPK/SIRT1 axis
  • Structural basis of CTRP3 receptor binding undetermined
  • Determinants of protective versus pathogenic signaling unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 4 GO:0098772 molecular function regulator activity 3
Localization
GO:0005576 extracellular region 4
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-1430728 Metabolism 3 R-HSA-168256 Immune System 3 R-HSA-1852241 Organelle biogenesis and maintenance 3
Partners
ADIPOR2JIP2LAMP1SCARB2

Evidence

Reading pass · 41 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 CTRP3 lowers blood glucose in normal and ob/ob mice by activating the Akt signaling pathway in liver and suppressing hepatic gluconeogenic gene expression; it acts directly and independently of insulin to reduce glucose output in cultured hepatocytes by suppressing gluconeogenic enzyme expression. Recombinant protein administration in vivo (mouse), Akt pathway analysis by Western blot, gluconeogenic gene expression in primary hepatocytes The Journal of biological chemistry High 20952387
2010 In humans, alternative splicing generates two circulating CTRP3 isoforms that form hetero-oligomers; this association does not require interdisulfide bond formation and protects the longer isoform from proteolytic cleavage. Biochemical characterization of recombinant human CTRP3 isoforms; hetero-oligomer formation assay; protease protection experiments The Journal of biological chemistry Medium 20952387
2005 Baculovirus-produced CTRP3 (CORS-26) forms stable trimers in insect cell supernatants and reduces IL-6 and TNF-α secretion from LPS-treated monocytic cells, likely through suppression of NF-κB signaling. Baculovirus expression system, SDS-PAGE/immunoblot for trimer characterization; ELISA for cytokine measurement; NF-κB reporter assay FEBS letters Medium 16213490
2013 Transgenic CTRP3 overexpression protects mice from high-fat diet-induced hepatic steatosis by reducing hepatic triglyceride content through decreased expression of triglyceride synthesis enzymes (GPAT, AGPAT, DGAT); recombinant CTRP3 treatment also directly reduces fatty acid synthesis and neutral lipid accumulation in cultured hepatocytes. Transgenic mouse model, hepatic triglyceride measurement, qPCR for lipogenic enzymes, recombinant protein treatment of H4IIE hepatocytes American journal of physiology. Gastrointestinal and liver physiology High 23744740
2007 CTRP3/cartducin promotes proliferation and migration of endothelial cells in a dose-dependent manner through activation of ERK1/2 and p38 MAPK; MEK1/2 inhibitor (U0126) blocks both proliferation and migration, while p38 inhibitor (SB203580) blocks only proliferation. Recombinant CTRP3 treatment of MSS31 endothelial cells; cell proliferation and migration assays; kinase inhibitor studies; Western blot for ERK1/2 and p38 phosphorylation Molecular and cellular biochemistry Medium 17534697
2010 TGF-β1 (but not bFGF or PDGF-BB) induces CTRP3/cartducin expression in vascular smooth muscle cells; exogenous CTRP3/cartducin promotes VSMC proliferation (but not migration) via ERK1/2 and p38 MAPK signaling pathways. Recombinant CTRP3 treatment of p53LMAC01 VSMCs; TGF-β1 stimulation; cell proliferation and migration assays; kinase inhibitor studies Cell biology international Medium 19947921
2009 Recombinant CTRP3 promotes osteosarcoma cell (NHOS and LM8) proliferation (but not migration) through activation of the ERK1/2 signaling pathway; MEK1/2 inhibitor U0126 blocks this effect. Recombinant CTRP3 treatment of osteosarcoma cell lines; proliferation and migration assays; Western blot for ERK1/2 phosphorylation; MEK inhibitor U0126 Oncology reports Medium 19424626
2012 CTRP3 stimulates testosterone production in TM3 mouse Leydig cells in a dose-dependent manner by upregulating StAR protein and P450scc expression through the cAMP/PKA signaling pathway; PKA inhibitor H89 blocks this effect. Recombinant CTRP3 treatment of TM3 cells; testosterone ELISA; cAMP measurement; CREB phosphorylation by Western blot; PKA inhibitor H89 Cytokine Medium 22342437
2013 C1qtnf3 knockout mice show increased incidence and severity of collagen-induced arthritis, higher anti-type II collagen antibody levels, and elevated pro-inflammatory cytokine mRNA, establishing CTRP3 as a negative regulator of autoimmune arthritis. C1qtnf3 knockout mouse model; collagen-induced arthritis; histopathology; ELISA; qPCR for cytokines Biochemical and biophysical research communications High 24269820
2015 CTRP3 attenuates cardiac fibrosis post-myocardial infarction by inhibiting myofibroblast differentiation and ECM production; mechanistically, CTRP3 activates AMPK and Akt in cardiac fibroblasts and inhibits TGF-β1-induced Smad3 phosphorylation, nuclear translocation, and interaction with p300; AMPK inhibitor AraA abolishes the anti-fibrotic effect. Adenovirus-mediated CTRP3 overexpression in rat post-MI model; adult rat cardiac fibroblast culture; AMPK inhibitor AraA; Western blot for Smad3 phosphorylation; Co-IP for Smad3-p300 interaction; siRNA knockdown Journal of molecular medicine (Berlin, Germany) High 26138247
2017 CTRP3 protects against diabetic cardiomyopathy by activating AMPKα via the cAMP-EPAC-MEK pathway; AMPKα deficiency abolishes CTRP3's protective effects against high-glucose-induced oxidative stress, inflammation, and apoptosis. Adeno-associated virus CTRP3 overexpression in STZ-diabetic rats; H9c2 cell culture; AMPKα knockout/inhibition; pathway inhibitors for cAMP/EPAC/MEK; Western blot; TUNEL assay Diabetologia High 28258411
2017 CTRP3 protects against doxorubicin-induced cardiac injury via activation of Sirt1; specific Sirt1 inhibition or siRNA silencing abolishes CTRP3's protective effects against DOX-induced inflammation and apoptosis. AAV CTRP3 cardiac overexpression in DOX-treated mice; H9C2 cell culture; Sirt1 inhibitor; Sirt1 siRNA; Western blot; TUNEL assay Journal of molecular and cellular cardiology High 29061338
2016 Globular CTRP3 promotes mitochondrial biogenesis in cardiomyocytes via the AMPK/PGC-1α pathway; CTRP3 increases AMPK phosphorylation, Sirtuin1 expression and activity, and downstream PGC-1α/NRF-1/TFAM/complex III/V; AMPK inhibitor AraA and Sirt1 inhibitor EX-527 attenuate these effects; PGC-1α siRNA blocks CTRP3-induced mitochondrial biogenesis. Recombinant globular CTRP3 treatment of neonatal rat ventricular myocytes; AMPK inhibitor AraA; Sirt1 inhibitor EX-527; PGC-1α siRNA; mitochondrial morphology by TEM; ATP measurement; OCR measurement; mtDNA copy number Biochimica et biophysica acta. General subjects High 27793739
2015 CTRP3 acts as a negative regulator of RANKL-induced osteoclastogenesis through the AMPK-c-Fos-NFATc1 signaling axis; CTRP3 activates AMPK in bone marrow macrophages and inhibits RANKL-induced c-Fos and NFATc1 expression, F-actin formation, and bone resorption; CTRP3 also reduces osteoclast formation and bone destruction in mouse calvarial bone in vivo. Recombinant CTRP3 treatment of mouse bone marrow macrophages; co-culture osteoclastogenesis assay; Western blot for AMPK, c-Fos, NFATc1; calvarial bone injection model; micro-CT; histology Bone High 26103094
2016 Identification of LAMP1 (lysosomal-associated membrane protein 1) and LIMP II as putative receptors for CTRP3 on hepatoma cells using ligand-receptor glycocapture (LRC-TriCEPS) technology; Co-IP confirmed LAMP1-CTRP3 association; a polyclonal antibody blocking LAMP1 prevented CTRP3 binding to cells. LRC-TriCEPS ligand-receptor capture; Co-immunoprecipitation; FACS; antibody-blocking assay in H4IIE cells PloS one Medium 27727322
2004 The transcription factors SP-1, PPARγ, and Pit-1 bind specifically to the murine CORS-26 (CTRP3) promoter; SP-1 exerts inhibitory (repressive) effects on CORS-26 transcriptional activation in an SP-3-independent manner. EMSA with nuclear extracts from 3T3-L1 adipocytes; supershift assay; competition experiments; mutated SP-1 binding site oligonucleotides; luciferase reporter gene assay Biochimica et biophysica acta Medium 15157741
2014 Recombinant CTRP3 attenuates LPS-induced systemic inflammation (serum IL-6 and MIP-2) and suppresses LPS-induced ERK-1/-2 phosphorylation in inguinal adipose tissue when administered intraperitoneally in mice; intravenous CTRP3 administration was not sufficient to produce these effects. Intraperitoneal and intravenous recombinant CTRP3 administration in C57BL/6N mice challenged with LPS; ELISA for serum cytokines; qPCR for adipose cytokine mRNA; Western blot for ERK-1/-2 phosphorylation Biochemical and biophysical research communications Medium 24996172
2016 CTRP3 promotes energy (ATP) production in vascular smooth muscle cells by increasing mitochondrial ROS production and upregulating PGC-1α and oxidative phosphorylation complexes; ROS scavenger N-acetyl-L-cysteine and OXPHOS uncoupler CCCP suppress CTRP3-induced ROS, PGC-1α, and ATP synthesis. Recombinant CTRP3 treatment of VSMCs; CTRP3 siRNA knockdown; PGC-1α siRNA; ATP assay; mitochondrial ROS measurement; Western blot for OXPHOS complexes; N-acetyl-L-cysteine and CCCP treatment Experimental cell research Medium 26844631
2011 CTRP3/cartducin is required for maintenance of the perichondrium and normal chondrocyte proliferation/differentiation in Meckel's cartilage and mandibular condylar cartilage; antisense oligodeoxynucleotide (AS-ODN) abrogation of CTRP3 in organ culture caused curvature deformation, loss of perichondrium, ectopic cartilage formation, reduced BrdU incorporation, and decreased aggrecan/collagen expression; these effects were partially rescued by recombinant CTRP3. In situ hybridization; antisense ODN organ culture system; BrdU incorporation; immunostaining; recombinant CTRP3 rescue experiment Journal of anatomy Medium 21371032
2015 CTRP3-deficient mice on high-fat diet have markedly reduced liver sizes and decreased profibrotic TGFβ1 levels, but markedly increased circulating IL-6; loss of CTRP3 had minimal impact on whole body glucose metabolism or insulin sensitivity, contrary to expectation from gain-of-function studies. Genetic knockout mouse model (Ctrp3-KO); HFD feeding; hyperinsulinemic-euglycemic clamp; liver weight and histology; ELISA for TGFβ1 and IL-6; liver gene expression by qPCR American journal of physiology. Endocrinology and metabolism High 26670485
2016 In a mouse model of endotoxemia or high-fat diet, genetic CTRP3 deficiency or transgenic overexpression did not significantly affect circulating IL-1β, IL-6, TNF-α, or MIP-2 induction by LPS, contrary to findings from recombinant CTRP3 protein administration; CTRP3 transgenic mice had elevated chemokines (CCL11, CXCL9, CXCL10, etc.) on low-fat diet but lower IL-5 and TNF-α on high-fat diet. CTRP3 knockout and transgenic mouse models; LPS challenge; multiplex serum cytokine profiling (71 cytokines); HFD metabolic challenge Physiological reports High 26997632
2021 CTRP3 suppresses Th17 cell differentiation but not Th1 differentiation via AdipoR2 (not AdipoR1); this suppression is associated with reduced Rorc and Stat3 expression; CTRP3-deficient mice show augmented Th17 cell populations and enhanced myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis; CTRP3 inhibits IL-17 production from T cells by affecting both T cells and dendritic cells. C1qtnf3 knockout mice; Th17 and Th1 differentiation assays in vitro; AdipoR1/AdipoR2 receptor antagonist treatment; AdipoRon agonist; EAE mouse model; flow cytometry for Th17 populations; qPCR for Rorc and Stat3 Frontiers in immunology High 34925309
2019 CTRP3 regulates mTOR-dependent axonal local protein translation in motor neurons via a muscle-to-neuron secretion mechanism; CTRP3 levels are reduced in SMA muscle secretome and serum; exogenous CTRP3 enhances axonal outgrowth and protein synthesis (including SMN) via the mTOR pathway. Quantitative proteomics with metabolic labeling of SMA muscle secretome; CTRP3 measurement in SMA mouse model tissue and serum; mTOR pathway analysis; axonal outgrowth assay; protein synthesis rate measurement in motor neurons Acta neuropathologica communications Medium 31615574
2021 CTRP3 exacerbates tendinopathy by promoting abnormal differentiation of tendon stem/progenitor cells toward chondrogenic lineage (ectopic chondrification) through Akt signaling; CTRP3 knockdown suppresses tendinopathy pathogenesis, and a neutralizing antibody against CTRP3 ameliorates overuse-induced Achilles and rotator cuff tendinopathy in mice. CTRP3 overexpression and knockdown mouse models; neutralizing antibody treatment; transcriptomic analysis; Akt pathway analysis; histology (proteoglycan/collagen fiber analysis); micro-CT Science advances High 34797714
2022 CTRP3 exerts anti-inflammatory effects in endothelial cells by inhibiting LPS-induced expression of IL-6, TNF-α, VCAM-1, and ICAM-1 and blocking monocyte adhesion to endothelial monolayers; CTRP3 mRNA is expressed in primary endothelial cells and aorta, and is transiently upregulated by LPS in murine endothelial cells. qPCR tissue expression analysis; MyEND cell culture; LPS stimulation; CTRP3 treatment; monocyte adhesion assay; ELISA/qPCR for adhesion molecules and cytokines Cells Medium 34440913
2022 CTRP3 attenuates intestinal inflammation via a SIRT1/NF-κB signaling axis; CTRP3-KO mice develop more severe colitis with decreased SIRT1, increased phosphorylated/acetylated NF-κB p65, and increased TNF-α and IL-6; CTRP3 transgenic mice show opposite effects; SIRT1 activator (resveratrol) rescues KO organoids and SIRT1 inhibitor (Ex-527) attenuates Tg organoid protection. CTRP3 KO and transgenic mice; DSS-induced colitis model; intestinal organoids; resveratrol and Ex-527 pharmacological modulation; Western blot for SIRT1/NF-κB; cytokine measurement; histology Cellular and molecular gastroenterology and hepatology High 36592863
2022 CTRP3 alleviates pathological cardiac hypertrophy and mitochondrial dysfunction by activating mitochondrial unfolded protein response (UPRmt) through the SIRT1/ATF5 axis; ATF5 knockout prevents CTRP3 cardioprotection; SIRT1 knockout blocks CTRP3's protective effects; ATF5 may be regulated by SIRT1 downstream of CTRP3. CTRP3 KO and lentivirus-overexpressing mice; TAC cardiac hypertrophy model; neonatal rat cardiomyocytes with siRNA/overexpression; Western blot for UPRmt markers; mitochondrial function assays; cardiac function measurements Cell death discovery High 38278820
2019 CTRP3 attenuates high-fat diet-induced spermatogenic impairment through the SIRT1/ER stress pathway; recombinant globular CTRP3 reduces endoplasmic reticulum stress and activates SIRT1 in testes; germ cell-specific SIRT1 knockout abolishes CTRP3 protection in vivo and in vitro. HFD mouse model; recombinant globular CTRP3 infusion; germ cell-specific SIRT1 knockout; ER stress markers by Western blot; sperm count/motility/viability assays; SIRT1 inhibitor in human sperm Clinical science (London, England : 1979) High 29572383
2022 CTRP3 physically interacts with LAMP1 and exerts anti-inflammatory effects in psoriatic keratinocytes by blocking STAT3 phosphorylation via LAMP1; Co-IP confirmed the CTRP3-LAMP1 interaction, and LAMP1-mediated STAT3 inhibition was demonstrated in vitro. Co-immunoprecipitation for CTRP3-LAMP1 interaction; STAT3 phosphorylation assay; imiquimod-induced psoriasis mouse model; GLP-1 receptor agonist (exendin-4) treatment; topical CTRP3 application The Journal of investigative dermatology Medium 34687744
2022 CTRP3 alleviates myocardial ischemia/reperfusion injury through activation of the LAMP1/JIP2/JNK signaling pathway; Co-IP identified physical interactions between CTRP3 and LAMP1, and between LAMP1 and JIP2; LAMP1 silencing worsened I/R injury and suppressed JIP2 and JNK; JNK inhibitor (SP600125) reversed CTRP3 overexpression-mediated protection. Co-immunoprecipitation (CTRP3-LAMP1-JIP2 interaction); CTRP3 overexpression/knockdown in mouse I/R model; LAMP1 siRNA; JNK inhibitor SP600125; Western blot; TUNEL assay; infarct size measurement International immunopharmacology Medium 35278832
2018 CTRP3 overexpression in cardiomyocytes protects against sepsis-induced myocardial dysfunction by activating AMPKα signaling and blunting NF-κB-mediated inflammation; CTRP3 overexpression increases AMPKα phosphorylation and decreases phospho-NF-κB p65 and IκBα. Intramyocardial CTRP3 injection in LPS-induced sepsis mouse model; Western blot for AMPKα, NF-κB p65, IκBα; TUNEL assay; cardiac function measurement Molecular and cellular endocrinology Medium 29655602
2018 CTRP3 overexpression in C1QTNF3 transgenic mice reduces hepatic triglyceride accumulation in response to chronic alcohol consumption (6-week model) by increasing hepatic fatty acid oxidation (increased oxygen consumption in the presence of fatty acids in isolated hepatocytes); this effect was not seen in a short-term NIAAA model. CTRP3 transgenic mice; chronic and NIAAA ALD models; hepatic triglyceride measurement; oxygen consumption rate in isolated primary hepatocytes American journal of physiology. Endocrinology and metabolism Medium 29763374
2021 C1QTNF3 is primarily expressed in fibroblasts (not adipocytes or macrophages) in adipose tissue and promotes macrophage chemotaxis and M1-like polarization via ERK and Akt pathway activation; neutralizing antibody against C1QTNF3 inhibited macrophage accumulation in tumor-associated inguinal adipose tissue in vivo. C1QTNF3 expression analysis in adipose cell fractions; recombinant C1QTNF3 treatment of M1/M2 macrophages; chemotaxis assay; ERK and Akt Western blot; nitric oxide production; Seahorse metabolic assay; neutralizing antibody in vivo Frontiers in immunology Medium 35720277
2014 GLP-1 receptor agonist Exendin-4 increases CTRP3 mRNA and protein expression in 3T3-L1 adipocytes via the PKA signaling pathway; this effect is blocked by GLP-1 receptor antagonist (Exendin-fragment 9-39) and PKA inhibitor H89. 3T3-L1 adipocyte culture; Exendin-4 treatment; GLP-1 receptor antagonist (Ex-9); PKA inhibitor H89; qPCR and Western blot for CTRP3 Journal of endocrinological investigation Medium 25149084
2018 CTRP3 is expressed in ovarian granulosa cells and oocytes, is upregulated by gonadotropin, downregulated by excess androgen, and promotes follicle growth by activating AKT/mTOR/p70S6K/4EBP1 signaling, increasing CCND2 expression, and reducing caspase-3 cleavage; intrabursal administration of CTRP3 antibody delayed gonadotropin-induced antral follicle development in vivo. qPCR and Western blot for C1qtnf3 in ovary; in vitro follicle/granulosa cell culture with recombinant C1QTNF3; AKT/mTOR/p70S6K/4EBP1 Western blot; CASP3/7 activity assay; intrabursal antibody injection in vivo; ovarian explant culture Reproduction (Cambridge, England) Medium 29438034
2019 CTRP3 deficiency delays endochondral fracture healing in mice, resulting in abnormal mineral distribution and a nonunion-like state with decreased osteoclast number; CTRP3 transgenic mice show accelerated callus remodeling; gene expression profiling reveals broad impact on osteoblast/osteoclast lineage commitment. CTRP3 KO and transgenic mice; femoral fracture model; micro-CT; histology; TRAP staining for osteoclasts; gene expression profiling Journal of orthopaedic research Medium 31808575
2020 CTRP3 ameliorates cerulein-induced severe acute pancreatitis by activating SIRT1, which suppresses NF-κB p65 phosphorylation and p53 acetylation; CTRP3 overexpression attenuated pathological lesions, inflammatory mediator release, and acinar cell apoptosis in SAP mice. Cerulein/LPS-induced SAP mouse model; CTRP3 overexpression; Western blot for SIRT1, phospho-NF-κB p65, acetylated p53; histology; ELISA for inflammatory mediators Bioscience reports Medium 32219332
2017 CTRP3 (cartonectin) is detectable in human cerebrospinal fluid with a mean CSF/serum ratio of ~110 × 10⁻³, demonstrating blood-brain barrier permeability; fatty acids (but not glucose) differentially modulate CTRP3 mRNA expression in 3T3-L1 adipocytes in vitro. ELISA measurement of paired CSF/serum samples (n=270); oral glucose/lipid tolerance test (n=100 each); 3T3-L1 adipocyte stimulation with glucose, sex hormones, and fatty acids; qPCR for CTRP3 mRNA European journal of clinical investigation Medium 27930815
2020 CTRP3 activates the AMPK/SIRT1-PGC-1α pathway to protect mitochondrial biogenesis and function in hippocampal neurons; PGC-1α silencing partially abolishes CTRP3's mitochondrial protective function after OGD/R treatment. OGD/R hippocampal neuronal cell model; CTRP3 overexpression; PGC-1α siRNA; AMPK/SIRT1/PGC-1α pathway Western blot; mitochondrial function assays Neurochemical research Medium 33098065
2021 CTRP3 promotes TNF-α-induced apoptosis and barrier dysfunction in salivary gland ductal epithelial cells by enhancing TNFR1 expression, suppressing c-FLIP, and increasing recruitment of FADD with RIP1 and caspase-8 (complex II pathway); Co-IP confirmed CTRP3 interaction with these components. Human SMG tissue culture and SMG-C6 cells; flow cytometry for apoptosis; Co-immunoprecipitation for FADD/RIP1/caspase-8; transepithelial resistance and paracellular tracer flux; Western blot for TNFR1, c-FLIP, cleaved caspase-3 Cellular signalling Medium 33991612
2022 FOXO4 directly binds the CTRP3 promoter and transcriptionally represses CTRP3 expression in retinal pericytes under high glucose conditions; FOXO4 upregulation in HG reduces CTRP3, which modulates the Nrf2/NF-κB signaling pathway; FOXO4 re-upregulation reverses CTRP3-mediated protection. JASPAR bioinformatics; ChIP assay; luciferase reporter assay for FOXO4-CTRP3 promoter interaction; FOXO4 and CTRP3 siRNA in retinal pericytes; Western blot for Nrf2/NF-κB; CCK-8; TUNEL; oxidative stress markers Bioengineered Medium 35196182

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. The Journal of biological chemistry 219 20952387
2017 CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats. Diabetologia 146 28258411
2017 CTRP3 protected against doxorubicin-induced cardiac dysfunction, inflammation and cell death via activation of Sirt1. Journal of molecular and cellular cardiology 141 29061338
2013 CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism. American journal of physiology. Gastrointestinal and liver physiology 112 23744740
2005 The adiponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells. FEBS letters 89 16213490
2015 CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation. Journal of molecular medicine (Berlin, Germany) 82 26138247
2012 C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome. Diabetes 81 22837306
2011 C1q/TNF-related protein-3 (CTRP-3) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts. Inflammatory bowel diseases 81 21351204
2013 Implication of progranulin and C1q/TNF-related protein-3 (CTRP3) on inflammation and atherosclerosis in subjects with or without metabolic syndrome. PloS one 80 23409033
2017 C1q/TNF-Related Protein 3 (CTRP3) Function and Regulation. Comprehensive Physiology 74 28640446
2007 CTRP3/cartducin promotes proliferation and migration of endothelial cells. Molecular and cellular biochemistry 66 17534697
2015 Lower Circulating C1q/TNF-Related Protein-3 (CTRP3) Levels Are Associated with Obesity: A Cross-Sectional Study. PloS one 64 26222183
2021 Up-regulating lncRNA OIP5-AS1 protects neuron injury against cerebral hypoxia-ischemia induced inflammation and oxidative stress in microglia/macrophage through activating CTRP3 via sponging miR-186-5p. International immunopharmacology 60 33516048
2013 CTRP3 plays an important role in the development of collagen-induced arthritis in mice. Biochemical and biophysical research communications 60 24269820
2015 Serum C1q/TNF-related protein-3 (CTRP3) levels are decreased in obesity and hypertension and are negatively correlated with parameters of insulin resistance. Diabetology & metabolic syndrome 59 25878729
2009 Effects of the new adiponectin paralogous protein CTRP-3 and of LPS on cytokine release from monocytes of patients with type 2 diabetes mellitus. Cytokine 59 19955001
2011 Anal canal cancer: management of inguinal nodes and benefit of prophylactic inguinal irradiation (CORS-03 Study). International journal of radiation oncology, biology, physics 57 21570207
2016 A brief glimpse at CTRP3 and CTRP9 in lipid metabolism and cardiovascular protection. Progress in lipid research 56 27743997
2016 Association of C1q/TNF-Related Protein-3 (CTRP3) and CTRP13 Serum Levels with Coronary Artery Disease in Subjects with and without Type 2 Diabetes Mellitus. PloS one 56 28033351
2014 Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris. Cardiovascular diabetology 53 24417980
2019 CTRP3 Alleviates Ox-LDL-Induced Inflammatory Response and Endothelial Dysfunction in Mouse Aortic Endothelial Cells by Activating the PI3K/Akt/eNOS Pathway. Inflammation 51 30887395
2014 C1q/TNF-related protein-3 (CTRP-3) attenuates lipopolysaccharide (LPS)-induced systemic inflammation and adipose tissue Erk-1/-2 phosphorylation in mice in vivo. Biochemical and biophysical research communications 48 24996172
2014 Low serum cartonectin/CTRP3 concentrations in newly diagnosed type 2 diabetes mellitus: in vivo regulation of cartonectin by glucose. PloS one 48 25409499
2013 Metformin increases the novel adipokine cartonectin/CTRP3 in women with polycystic ovary syndrome. The Journal of clinical endocrinology and metabolism 47 24152681
2020 CTRP3 Activates the AMPK/SIRT1-PGC-1α Pathway to Protect Mitochondrial Biogenesis and Functions in Cerebral Ischemic Stroke. Neurochemical research 45 33098065
2016 Globular CTRP3 promotes mitochondrial biogenesis in cardiomyocytes through AMPK/PGC-1α pathway. Biochimica et biophysica acta. General subjects 45 27793739
2015 CTRP3 deficiency reduces liver size and alters IL-6 and TGFβ levels in obese mice. American journal of physiology. Endocrinology and metabolism 45 26670485
2008 Effects of the new C1q/TNF-related protein (CTRP-3) "cartonectin" on the adipocytic secretion of adipokines. Obesity (Silver Spring, Md.) 45 18421280
2017 CTRP3 is a novel biomarker for diabetic retinopathy and inhibits HGHL-induced VCAM-1 expression in an AMPK-dependent manner. PloS one 43 28632765
2016 Immunomodulatory roles of CTRP3 in endotoxemia and metabolic stress. Physiological reports 43 26997632
2018 Overexpression of CTRP3 protects against sepsis-induced myocardial dysfunction in mice. Molecular and cellular endocrinology 41 29655602
2007 Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults. Cardiovascular diabetology 41 17311679
2013 Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels. Diabetes care 39 23780948
2015 CTRP3 acts as a negative regulator of osteoclastogenesis through AMPK-c-Fos-NFATc1 signaling in vitro and RANKL-induced calvarial bone destruction in vivo. Bone 37 26103094
2018 Impact of weight cycling on CTRP3 expression, adipose tissue inflammation and insulin sensitivity in C57BL/6J mice. Experimental and therapeutic medicine 36 30186439
2015 Plasma CTRP-3 concentrations in Chinese patients with obesity and type II diabetes negatively correlate with insulin resistance. Journal of clinical lipidology 36 26073386
2019 C1q/TNF-related protein 3 (CTRP3) and 9 (CTRP9) concentrations are decreased in patients with heart failure and are associated with increased morbidity and mortality. BMC cardiovascular disorders 34 31182031
2009 Elevated expression of CTRP3/cartducin contributes to promotion of osteosarcoma cell proliferation. Oncology reports 34 19424626
2019 CTRP3 acts as a novel regulator in depressive-like behavior associated inflammation and apoptosis by meditating p38 and JNK MAPK signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 32 31629950
2021 CTRP3 exacerbates tendinopathy by dysregulating tendon stem cell differentiation and altering extracellular matrix composition. Science advances 31 34797714
2016 Identification of Putative Receptors for the Novel Adipokine CTRP3 Using Ligand-Receptor Capture Technology. PloS one 31 27727322
2010 CTRP3/cartducin is induced by transforming growth factor-beta1 and promotes vascular smooth muscle cell proliferation. Cell biology international 31 19947921
2010 High-dose split-course radiation therapy for anal cancer: outcome analysis regarding the boost strategy (CORS-03 study). International journal of radiation oncology, biology, physics 31 20619552
2019 CTRP3 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells. Artificial cells, nanomedicine, and biotechnology 30 31556307
2014 CTRP3 improves the insulin sensitivity of 3T3-L1 adipocytes by inhibiting inflammation and ameliorating insulin signalling transduction. Endokrynologia Polska 30 25185846
2012 The adiponectin paralog C1q/TNF-related protein 3 (CTRP3) stimulates testosterone production through the cAMP/PKA signaling pathway. Cytokine 30 22342437
2016 Divergent relationship of circulating CTRP3 levels between obesity and gender: a cross-sectional study. PeerJ 29 27781167
2020 New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions. Frontiers in physiology 28 33343381
2018 CTRP3 attenuates high-fat diet-induced male reproductive dysfunction in mice. Clinical science (London, England : 1979) 28 29572383
2003 Genomic organization, promoter, amino acid sequence, chromosomal localization, and expression of the human gene for CORS-26 (collagenous repeat-containing sequence of 26-kDa protein). Biochimica et biophysica acta 28 14654242
2019 Serum levels of CTRP3 in diabetic nephropathy and its relationship with insulin resistance and kidney function. PloS one 26 31009504
2018 Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females. PloS one 25 30557342
2016 CTRP3 promotes energy production by inducing mitochondrial ROS and up-expression of PGC-1α in vascular smooth muscle cells. Experimental cell research 25 26844631
2014 CTRP3 modulates the expression and secretion of adipokines in 3T3-L1 adipocytes. Endocrine journal 25 25168658
2012 Role of brachytherapy in the boost management of anal carcinoma with node involvement (CORS-03 study). International journal of radiation oncology, biology, physics 25 23195780
2003 Genomic organization, chromosomal localization and adipocytic expression of the murine gene for CORS-26 (collagenous repeat-containing sequence of 26 kDa protein). Biochimica et biophysica acta 25 12850274
2020 Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT signaling pathways. European review for medical and pharmacological sciences 24 32432773
2014 Expression of CTRP3, a novel adipokine, in rats at different pathogenic stages of type 2 diabetes mellitus and the impacts of GLP-1 receptor agonist on it. Journal of diabetes research 24 25177707
2018 CTRP3 inhibits high glucose-induced human glomerular mesangial cell dysfunction. Journal of cellular biochemistry 23 30362596
2015 CTRP3 Stimulates Proliferation and Anti-Apoptosis of Prostate Cells through PKC Signaling Pathways. PloS one 23 26218761
2014 Effect of CTRP3 on activation of adventitial fibroblasts induced by TGF-β1 from rat aorta in vitro. International journal of clinical and experimental pathology 23 24966928
2011 Functional analysis of CTRP3/cartducin in Meckel's cartilage and developing condylar cartilage in the fetal mouse mandible. Journal of anatomy 23 21371032
2004 Role of specificity protein-1, PPARgamma, and pituitary protein transcription factor-1 in transcriptional regulation of the murine CORS-26 promoter. Biochimica et biophysica acta 22 15157741
2020 Association of Plasma C1q/TNF-Related Protein 3 (CTRP3) in Patients with Atrial Fibrillation. Mediators of inflammation 21 33424438
2000 Phosphorylation of CorS and CorR, regulatory proteins that modulate production of the phytotoxin coronatine in Pseudomonas syringae. FEMS microbiology letters 21 11094272
2019 Muscle regulates mTOR dependent axonal local translation in motor neurons via CTRP3 secretion: implications for a neuromuscular disorder, spinal muscular atrophy. Acta neuropathologica communications 20 31615574
2017 CTRP-3 is permeable to the blood-brain barrier and is not regulated by glucose or lipids in vivo. European journal of clinical investigation 20 27930815
2020 CTRP3 ameliorates cerulein-induced severe acute pancreatitis in mice via SIRT1/NF-κB/p53 axis. Bioscience reports 19 32219332
2014 GLP-1 receptor agonist increases the expression of CTRP3, a novel adipokine, in 3T3-L1 adipocytes through PKA signal pathway. Journal of endocrinological investigation 19 25149084
2024 CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis. Cell death discovery 18 38278820
2021 MicroRNA miR-495 regulates the development of Hepatocellular Carcinoma by targeting C1q/tumor necrosis factor-related protein-3 (CTRP3). Bioengineered 17 34516334
2021 The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation. Frontiers in immunology 17 34925309
2022 C1q/tumor necrosis factor-related protein-3 (CTRP3) activated by forkhead box O4 (FOXO4) down-regulation protects retinal pericytes against high glucose-induced oxidative damage through nuclear factor erythroid 2-related factor 2 (Nrf2)/Nuclear factor-kappaB (NF-κB) signaling. Bioengineered 16 35196182
2022 C1QTNF3 is Upregulated During Subcutaneous Adipose Tissue Remodeling and Stimulates Macrophage Chemotaxis and M1-Like Polarization. Frontiers in immunology 16 35720277
2017 Low serum CTRP3 levels are associated with nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. Cytokine 16 29113741
2022 African swine fever virus infection activates inflammatory responses through downregulation of the anti-inflammatory molecule C1QTNF3. Frontiers in immunology 15 36311798
2020 MiR-144 affects proliferation and apoptosis of high glucose-induced AC16 cardiomyocytes by regulating CTRP3/JNK signaling. International journal of clinical and experimental pathology 15 32211094
2020 Plasma miR-409-3p promotes acute cerebral infarction via suppressing CTRP3. The Kaohsiung journal of medical sciences 15 33336518
2018 Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation. American journal of physiology. Endocrinology and metabolism 15 29763374
2017 Association of serum C1q/TNF-related protein-3 (CTRP-3) in patients with coronary artery disease. BMC cardiovascular disorders 15 28754090
2017 Expression of C1q/TNF-related protein-3 (CTRP3) in serum of patients with gestational diabetes mellitus and its relationship with insulin resistance. European review for medical and pharmacological sciences 15 29272006
2019 CTRP3 Protects against High Glucose-Induced Cell Injury in Human Umbilical Vein Endothelial Cells. Analytical cellular pathology (Amsterdam) 14 31428552
2004 Topological and deletion analysis of CorS, a Pseudomonas syringae sensor kinase. Microbiology (Reading, England) 14 15289568
2022 Astragaloside IV Regulates Insulin Resistance and Inflammatory Response of Adipocytes via Modulating CTRP3 and PI3K/AKT Signaling. Diabetes therapy : research, treatment and education of diabetes and related disorders 13 36103112
2021 Adipocyte-Derived CTRP3 Exhibits Anti-Inflammatory Effects via LAMP1-STAT3 Axis in Psoriasis. The Journal of investigative dermatology 13 34687744
2019 CTRP3 Regulates Endochondral Ossification and Bone Remodeling During Fracture Healing. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 13 31808575
2022 CTRP3 alleviates myocardial ischemia/reperfusion injury in mice through activating LAMP1/JIP2/JNK pathway. International immunopharmacology 12 35278832
2020 Circulating levels of CTRP3 in patients with type 2 diabetes mellitus compared to controls: A systematic review and meta-analysis. Diabetes research and clinical practice 12 32949652
2020 Downregulation of CTRP-3 by Weight Loss In Vivo and by Bile Acids and Incretins in Adipocytes In Vitro. International journal of molecular sciences 12 33142914
2020 Protective Role of CTRP3 and CTRP9 in the Development of Gestational Diabetes Mellitus. Clinical laboratory 12 33180446
2018 Serum CTRP3 level is inversely associated with nonalcoholic fatty liver disease: A 3-y longitudinal study. Clinica chimica acta; international journal of clinical chemistry 12 29305845
2018 C1QTNF3 in the murine ovary and its function in folliculogenesis. Reproduction (Cambridge, England) 12 29438034
2021 CTRP3 protects against uric acid-induced endothelial injury by inhibiting inflammation and oxidase stress in rats. Experimental biology and medicine (Maywood, N.J.) 11 34601891
2020 Increased mRNA Expression of CTRP3 and CTRP9 in Adipose Tissue from Obese Women: Is it Linked to Obesity-Related Parameters and mRNA Expression of Inflammatory Cytokines? Reports of biochemistry & molecular biology 11 32821754
2022 Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-κB Signaling. Cellular and molecular gastroenterology and hepatology 10 36592863
2021 CTRP3 protects hippocampal neurons from oxygen-glucose deprivation-induced injury through the AMPK/Nrf2/ARE pathway. Human & experimental toxicology 10 33501881
2021 CTRP3 promotes TNF-α-induced apoptosis and barrier dysfunction in salivary epithelial cells. Cellular signalling 10 33991612
2021 Anti-Inflammatory Effects of C1q/Tumor Necrosis Factor-Related Protein 3 (CTRP3) in Endothelial Cells. Cells 10 34440913
2021 Administration of rTMS Alleviates Stroke-Induced Cognitive Deficits by Modulating miR-409-3p/CTRP3/AMPK/Sirt1 Axis. Journal of molecular neuroscience : MN 10 34655390
2019 Serum CTRP3 Levels In Obese Children: A Potential Protective Adipokine Of Obesity, Insulin Sensitivity And Pancreatic β Cell Function. Diabetes, metabolic syndrome and obesity : targets and therapy 10 31571966

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