Affinage

ADIPOR2

Adiponectin receptor protein 2 · UniProt Q86V24

Length
386 aa
Mass
43.9 kDa
Annotated
2026-06-09
100 papers in source corpus 33 papers cited in narrative 33 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ADIPOR2 is an atypical seven-transmembrane receptor whose conserved primary function is to maintain plasma membrane lipid homeostasis by sensing membrane rigidification and driving fatty acid desaturation, elongation, and incorporation of unsaturated fatty acids into phospholipids (PMID:28886012, PMID:30890562, PMID:33444759). In human cells and the C. elegans ortholog PAQR-2, ADIPOR2 counteracts the rigidifying effect of exogenous saturated fatty acids, and its loss prevents cells from restoring membrane fluidity after a palmitate challenge, producing transcriptome-wide misregulation of lipid metabolism genes that phenocopies SREBP deficiency (PMID:28886012, PMID:33444759, PMID:33444761, PMID:34839823). Mechanistically, ADIPOR2 promotes fatty acid elongation and PUFA incorporation through conserved interactors including the dehydratase HACD3 and the acyl-CoA synthetase ACSL4, sustains Δ9-desaturase (SCD) activity, and upregulates the elongase ELOVL2 (PMID:37164154, PMID:38485951). This activity operates cell-nonautonomously, normalizing membrane fluidity in distant ADIPOR2-deficient cells (PMID:29997234). ADIPOR2 protein stability is governed by the E3 ubiquitin ligase RNF145 in a lipid-saturation-dependent autoregulatory loop, in which saturated-FA enrichment triggers RNF145 auto-degradation to stabilize ADIPOR2 and restore lipid homeostasis (PMID:35993436). Beyond membrane homeostasis, ADIPOR2 transduces adiponectin signals: it sustains hepatic PPAR-alpha activity, fatty acid oxidation, and catalase-mediated control of lipid peroxidation, protecting against diabetes and steatohepatitis (PMID:17268472, PMID:18666257), and it couples through the adaptor APPL1 to Src/Ras-dependent ERK1/2 activation (PMID:18842004). The membrane-homeostasis role manifests in tissue-specific phenotypes including testis meiotic chromosome dynamics, where ADIPOR2 loss causes phospholipid saturation, nuclear envelope invagination, and defective synapsis and recombination (PMID:38485951), and brain phospholipid composition and behavior (PMID:38989587). ADIPOR2 also mediates contextual fear extinction and suppression of dentate gyrus neuronal excitability (PMID:27137743). Its cell-surface expression and temporal signaling profile are restricted by a non-conserved N-terminal cytoplasmic region and modulated by ligand-induced internalization (PMID:23376713, PMID:25892445), and its transcription is repressed by ER-stress-induced ATF3 binding to its promoter (PMID:20423458).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2007 High

    Established that ADIPOR2 is a functional adiponectin receptor whose signaling drives PPAR-alpha activity and hepatic fatty acid oxidation in vivo, defining its first molecular pathway.

    Evidence Reciprocal knockout and adenoviral overexpression in mice with adiponectin binding and metabolic phenotyping

    PMID:17268472

    Open questions at the time
    • Did not resolve whether PPAR-alpha activation is direct or downstream of membrane effects
    • No structural basis for receptor-ligand engagement
  2. 2008 High

    Defined the hepatic ADIPOR2-PPAR-alpha axis as protective in steatohepatitis by linking it to catalase expression and control of lipid peroxidation.

    Evidence Adenoviral knockdown/overexpression in MCD-diet mice and primary hepatocytes with ROS measurement

    PMID:18666257

    Open questions at the time
    • Mechanism connecting receptor to catalase transcription not defined
    • Liver-specific; relevance to other tissues unaddressed
  3. 2008 Medium

    Identified APPL1 as the adaptor coupling ADIPOR2 to a Src/Ras-dependent ERK1/2 signaling branch, distinguishing this from AMPK signaling.

    Evidence RNAi and pharmacological inhibition in HEK293 cells with Ras activation assays

    PMID:18842004

    Open questions at the time
    • Direct ADIPOR2-APPL1 binding not structurally mapped
    • Single cell-based model
  4. 2010 High

    Showed ADIPOR2 transcription is repressed under ER stress via direct ATF3 promoter binding, revealing a stress-responsive regulatory input.

    Evidence Promoter deletion reporters, EMSA, and ChIP with ATF3 manipulation

    PMID:20423458

    Open questions at the time
    • Physiological triggers of this repression in vivo not fully defined
  5. 2013 Medium

    Defined the non-conserved N-terminal region as the determinant restricting ADIPOR2 cell-surface expression and enabling heterodimerization with AdipoR1.

    Evidence Chimeric and truncated constructs with quantitative surface expression in HEK293 cells

    PMID:23376713

    Open questions at the time
    • Trafficking machinery retaining ADIPOR2 intracellularly not identified
    • Functional consequence of heterodimers unresolved
  6. 2013 High

    Established via the C. elegans ortholog PAQR-2 that this receptor family controls fatty acid desaturation for membrane fluidity during cold adaptation, defining the conserved membrane-homeostasis function.

    Evidence Forward genetic suppressor screen and epistasis with fatty acid composition analysis

    PMID:24068966

    Open questions at the time
    • Direct demonstration in mammalian ADIPOR2 not yet shown at this stage
    • Mechanism of fluidity sensing unknown
  7. 2015 Medium

    Demonstrated that membrane surface expression is required for signaling and that the divergent N-terminal trunks set distinct temporal signaling kinetics for AdipoR1 versus ADIPOR2.

    Evidence Chimeric constructs and phosphorylation time-course in HEK293 cells; crystallization of an N-terminally truncated construct to 2.4 Å

    PMID:25462574 PMID:25892445

    Open questions at the time
    • Full structural model of ADIPOR2 not reported
    • Internalization machinery not identified
  8. 2017 High

    Demonstrated the conserved, adiponectin-independent role of ADIPOR2 in countering saturated-FA-induced membrane rigidification in both worm and mammalian cells.

    Evidence C. elegans dietary FA manipulation and AdipoR2 siRNA in mammalian cells with direct membrane fluidity measurement

    PMID:28886012

    Open questions at the time
    • Molecular sensor of rigidification not yet identified
    • Effector enzymes recruited not defined
  9. 2018 High

    Showed the membrane-homeostasis function operates cell-nonautonomously and depends on Δ9-desaturases, extending the mechanism to systemic membrane regulation.

    Evidence C. elegans mosaic analysis and tissue-specific rescue plus co-culture and SCD silencing in HEK293 cells with FRAP

    PMID:29997234

    Open questions at the time
    • Nature of the transmissible signal between cells unknown
  10. 2019 High

    Established with three orthogonal biophysical methods that ADIPOR2 sustains desaturase expression and membrane PUFA content and prevents lipotoxicity even without adiponectin, defining membrane homeostasis as the primary cellular function.

    Evidence AdipoR2 siRNA in multiple human cell types with FRAP, Laurdan GP, and phospholipid mass spectrometry

    PMID:30890562

    Open questions at the time
    • Direct enzymatic activity of the receptor not yet established
    • How the receptor signals to desaturase genes unresolved
  11. 2021 High

    Defined ADIPOR2 as a transcriptional and lipidomic responder to membrane rigidification ranking among the most important regulators (with SCD) preventing SFA-induced rigidity, and linked its loss to ceramide precursor accumulation.

    Evidence Transcriptomics, lipidomics, and comparative gene silencing in HEK293 and HUVEC cells; sphingolipid lipidomics with bidirectional ADIPOR2 manipulation

    PMID:33444759 PMID:34839823

    Open questions at the time
    • Signal transduction from membrane state to transcription not mapped
  12. 2021 High

    Established through PAQR-2/IGLR-2 that a fluidity-regulated receptor interaction underlies SFA tolerance, providing a mechanistic model of membrane fluidity sensing.

    Evidence C. elegans forward screen, FRET-based interaction assay regulated by membrane fluidity, and domain deletion

    PMID:33444761

    Open questions at the time
    • Mammalian ADIPOR2 partner equivalent to IGLR-2 not identified in this work
  13. 2022 High

    Identified RNF145 as the E3 ligase controlling ADIPOR2 stability in a saturation-dependent autoregulatory loop, providing a post-translational mechanism coupling receptor levels to membrane lipid state.

    Evidence Systematic proteomics with ubiquitination and degradation assays and lipid homeostasis readouts in mammalian cells

    PMID:35993436

    Open questions at the time
    • How RNF145 senses saturation state not fully resolved
    • Proposed ADIPOR2 hydrolase activity not directly biochemically characterized
  14. 2023 High

    Defined the molecular machinery by which ADIPOR2 promotes PUFA elongation and incorporation through conserved interactors HACD3 and ACSL4, mechanistically grounding the membrane-homeostasis function.

    Evidence IP-MS of tagged ADIPOR2/PAQR-2 from human cells and C. elegans, 13C FA tracing, and functional interaction validation

    PMID:37164154

    Open questions at the time
    • Stoichiometry and structural arrangement of the receptor-enzyme assembly unknown
  15. 2024 High

    Connected the membrane-homeostasis function to a physiological process by showing ADIPOR2 drives meiotic VLC-PUFA synthesis via ELOVL2, with loss causing membrane stiffening and meiotic chromosome defects.

    Evidence AdipoR2 KO mice with testis lipidomics, ELOVL2 expression analysis, and meiotic chromosome assays

    PMID:38485951

    Open questions at the time
    • Whether ELOVL2 regulation is direct receptor-mediated or downstream of lipid state not resolved
  16. 2024 High

    Identified a ligand-activated ADIPOR2-CaM-CaMKII-NOS3 complex producing nitric oxide, revealing a rapid Ca2+-dependent signaling output distinct from the lipid-homeostasis role.

    Evidence Site-directed mutagenesis (R335, Y274), Co-IP of the complex, Ca2+ and NO assays, mouse ALF model and human liver organoids

    PMID:39681560

    Open questions at the time
    • Whether endogenous adiponectin engages this pathway not addressed
    • Integration with membrane-homeostasis function unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how ADIPOR2 directly senses membrane saturation state and transduces it into enzymatic and transcriptional outputs, and whether its proposed intrinsic hydrolase activity and the diverse tissue signaling roles (PPAR-alpha, AMPK, ERK, NO) are mechanistically unified.
  • No direct biochemical demonstration of ADIPOR2 hydrolase activity on a defined substrate
  • No full mammalian structural model linking fluidity sensing to effector recruitment
  • Mammalian equivalent of the IGLR-2 sensing partner unidentified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008289 lipid binding 2 GO:0060089 molecular transducer activity 2 GO:0140299 molecular sensor activity 2 GO:0016787 hydrolase activity 1
Localization
GO:0005886 plasma membrane 3 GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-1430728 Metabolism 3 R-HSA-8953897 Cellular responses to stimuli 3 R-HSA-162582 Signal Transduction 2
Partners
ACSL4ADIPOR1APPL1CAMKK2HACD3NOS3RNF145
Complex memberships
AdipoR2-CaM-CaMKII-NOS3 complex

Evidence

Reading pass · 33 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 Targeted disruption of AdipoR2 in mice resulted in decreased PPAR-alpha signaling pathway activity. Simultaneous disruption of AdipoR1 and AdipoR2 abolished adiponectin binding entirely. Adenovirus-mediated hepatic overexpression of AdipoR2 increased PPAR-alpha signaling and fatty acid oxidation, ameliorating diabetes in Lepr(-/-) mice. Targeted gene knockout mice, adenovirus-mediated overexpression in vivo, adiponectin binding assays, metabolic phenotyping Nature medicine High 17268472
2008 Hepatic AdipoR2 signaling regulates PPAR-alpha activity and catalase expression, thereby controlling lipid peroxidation (ROS accumulation). Adenoviral knockdown of AdipoR2 aggravated NASH by diminishing PPAR-alpha/ACO/catalase expression, while overexpression improved steatohepatitis by enhancing PPAR-alpha activity and reducing TGF-beta1-induced ROS in primary hepatocytes. Adenoviral shRNA knockdown and overexpression in vivo (MCD diet mouse model), primary hepatocyte cultures, PPAR-alpha signaling assays, ROS measurement Hepatology (Baltimore, Md.) High 18666257
2008 AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway. Adiponectin-induced ERK1/2 activation required APPL1 (adaptor protein), was abolished by Src family kinase inhibitor PP2 and Clostridium difficile toxin B (small GTPase inhibitor), and was associated with Src-dependent Ras (but not Rap1) activation. Either receptor alone was sufficient to mediate ERK1/2 activation. RNAi knockdown in HEK293 cells, pharmacological inhibitors (PP2, PKA inhibitor, toxin B), Ras activation assays, cell growth assays with overexpression Biochemistry Medium 18842004
2010 ERp46 interacts specifically with AdipoR1 but NOT AdipoR2. The interaction is mediated by the cytoplasmic N-terminal residues (1-70) of AdipoR1. ERp46 is present at both ER and plasma membrane. Knockdown of ERp46 increased surface levels of both AdipoR1 and AdipoR2 and enhanced adiponectin-stimulated AMPK phosphorylation, but reduced p38MAPK phosphorylation. Co-immunoprecipitation followed by mass spectrometry, GST-fusion protein pulldown with truncated constructs, indirect immunofluorescence, subcellular fractionation, transient siRNA knockdown, AMPK and p38MAPK phosphorylation assays Biochemical and biophysical research communications Medium 20074551
2010 ATF3, induced by ER stress, transcriptionally represses AdipoR2 expression. ER stress inducer thapsigargin decreased AdipoR2 protein and RNA levels concomitant with ATF3 induction. Chromatin immunoprecipitation and EMSA identified a specific ATF3-binding site at nucleotides -94 to -86 of the AdipoR2 promoter. Chemical chaperone PBA reversed these effects. Reporter gene assays with 5'-deleted AdipoR2 promoter constructs, ATF3 overexpression/knockdown, EMSA, chromatin immunoprecipitation, ob/ob mouse liver analysis The FEBS journal High 20423458
2011 In human macrophage foam cell formation, AdipoR2 (but not AdipoR1) is the dominant receptor for adiponectin suppression of scavenger receptor A type 1 (SR-AI) and upregulation of IL-1Ra. Both AdipoR1 and AdipoR2 are required for adiponectin-mediated suppression of lipid accumulation. APPL1 knockdown abrogated adiponectin inhibition of lipid accumulation, SR-AI, NF-κB, and Akt phosphorylation. Overexpression and lentiviral-shRNA knockdown of AdipoR1, AdipoR2, and APPL1 in THP-1 monocytes, oxLDL-induced foam cell transformation, gene expression assays Atherosclerosis Medium 22227293
2013 In C. elegans, PAQR-2 (AdipoR2 homolog) regulates fatty acid desaturation required for membrane fluidity during cold adaptation. Genetic suppressors of paqr-2 include genes in phosphatidylcholine synthesis and fatty acid metabolism pathways (sbp-1, Δ9-desaturases), establishing a cold adaptation pathway: paqr-2 → phosphatidylcholines/sbp-1 → Δ9-desaturases → unsaturated fatty acids → membrane fluidity. C. elegans suppressor screen, genetic epistasis analysis, fatty acid composition measurements, lipid analysis PLoS genetics High 24068966
2013 The non-conserved N-terminal region of AdipoR2 (residues 1-81) restricts its cell-surface expression. AdipoR1 is constitutively expressed at the cell surface, but AdipoR2 is not. Introduction of the AdipoR2 N-terminal region into AdipoR1 inhibited its surface expression; deletion from AdipoR2 promoted surface expression. AdipoR1 and AdipoR2 can form heterodimers, and co-expression enables AdipoR2 cell-surface localization. C-terminal epitope-tagged chimeric and truncated constructs, indirect immunofluorescence microscopy, quantitative plate-based surface expression analysis in HEK293 cells Biochemical and biophysical research communications Medium 23376713
2014 AdipoR2 deficiency in mice severely attenuated revascularization after hind limb ischemic surgery, and adiponectin treatment failed to rescue AdipoR2-deficient mice. In contrast, AdipoR2-deficient mice were protected from diet-induced obesity and metabolic dysfunction. AdipoR1 deficiency led to metabolic dysfunction but not vascular defects, revealing divergent receptor functions in vascular vs. metabolic homeostasis. AdipoR1- and AdipoR2-knockout mice, hind limb ischemia surgery model, diet-induced obesity model, blood flow recovery measurements, metabolic phenotyping The Journal of biological chemistry High 24742672
2015 AdipoR2 N-terminal truncation mutant (AdipoR2Δ99, residues 100-386) expressed as monodisperse protein in insect cells and was crystallized with anti-AdipoR1 Fv fragment by the lipidic mesophase method, yielding X-ray diffraction data to 2.4 Å resolution. Thermostability, thin-layer chromatography of bound lipids, and SPR ligand binding analyses confirmed structural integrity. Recombinant protein expression in insect cells, affinity and gel-filtration chromatography, thermostability assay, TLC, SPR, lipidic mesophase crystallization, X-ray diffraction Journal of structural and functional genomics Medium 25462574
2015 Cell-surface expression of AdipoR1 and AdipoR2 is required for effective downstream signaling. Adiponectin induces internalization of both receptors. The non-conserved N-terminal trunks (AdipoR1 residues 1-70; AdipoR2 residues 1-81) define divergent temporal signaling profiles: AdipoR1 signals peak at 15 min; AdipoR2 signals peak at 24 h. Transient expression of AdipoR1/R2 and chimeric constructs in HEK293 cells, serum-starvation, cell-surface expression quantification, phosphorylation time-course analysis of downstream effectors Molecular and cellular endocrinology Medium 25892445
2016 AdipoR2 (but not AdipoR1) in the dentate gyrus is necessary and sufficient for adiponectin-mediated facilitation of contextual fear extinction and suppression of intrinsic excitability of dentate gyrus granule neurons. Deletion of AdipoR2 in the DG caused augmented fear expression, reduced extinction, and intrinsic hyperexcitability. AdipoRon failed to suppress excitability in AdipoR2 knockout mice. Conditional AdipoR1/R2 knockout in dentate gyrus, contextual fear conditioning and extinction behavioral tests, whole-cell patch-clamp recordings in brain slices, AdipoRon pharmacology Molecular psychiatry High 27137743
2016 C. elegans paqr-2 (AdipoR2 homolog) mutants lacking paqr-2 or its partner iglr-2 are glucose intolerant and die in the presence of low glucose concentrations. PAQR-2 and IGLR-2 interact on plasma membranes (shown by bimolecular fluorescence complementation) and act as a fluidity sensor controlling membrane lipid composition via FRAP-measured membrane fluidity. This pathway is independent of the insulin receptor/FoxO (daf-2/daf-16) pathway. C. elegans genetics, FRAP (Fluorescence Recovery After Photobleaching) on living worms, bimolecular fluorescence complementation, genetic epistasis with daf-2/daf-16 PLoS genetics High 27082444
2017 AdipoR2 and its C. elegans homolog PAQR-2 are essential to counter membrane rigidification by exogenous saturated fatty acids. siRNA knockdown of AdipoR2 in mammalian cells prevented cells from counteracting the membrane-rigidifying effects of palmitic acid. Dietary SFA-rich diets cause membrane rigidity and lethality in paqr-2 mutants, rescued by dietary unsaturated FA supplements or genetic suppressors. C. elegans dietary supplementation with saturated/monounsaturated FAs, direct membrane fluidity measurements, AdipoR2 siRNA knockdown in mammalian cells, lipidomics PLoS genetics High 28886012
2017 AdipoR2 modulates collagen 1-alpha1 (Col1-α1) and alpha-SMA gene expression, hepatic stellate cell (HSC) migration, and AMPK activity in primary HSCs. AdipoR2 KO mice showed enhanced fibrotic gene expression (Col1-α1, TGF-β1, TIMP-1, IL-10, MMP-2, MMP-9) after CCl4-induced fibrosis, identifying AdipoR2 as the major adiponectin receptor on HSCs mediating anti-fibrotic effects. AdipoR1 and AdipoR2 KO mice with CCl4 fibrosis model, siRNA knockdown in primary HSCs, HSC migration assays, AMPK activity, gene expression analysis Biochimica et biophysica acta. Molecular basis of disease Medium 29237572
2017 Muscle-specific overexpression of AdipoR2 (but not AdipoR1) in tibialis anterior muscle increased PPARα and ACOX1 (acox1) expression, and uniquely promoted systemic effects in obese mice including decreased weight gain, reduced epididymal fat mass, reduced epididymal inflammation, and increased circulating adiponectin. In vivo electrotransfer-mediated overexpression of AdipoR1 or AdipoR2 in tibialis anterior muscle of lean and obese mice, tissue gene expression, metabolic phenotyping Scientific reports Medium 28145500
2018 PAQR-2 (AdipoR2 homolog) regulates membrane homeostasis cell nonautonomously in C. elegans: expression of paqr-2 in the hypodermis, gonad sheath cells, or intestine is sufficient to suppress systemic paqr-2 mutant membrane phenotypes in other tissues. In human HEK293 cells, AdipoR2-expressing cells normalize membrane fluidity in distant AdipoR2-silenced cells. Δ9 desaturases (SCD) are essential for this cell-nonautonomous membrane homeostasis. C. elegans mosaic analysis, tissue-specific rescue constructs, FRAP in C. elegans intestinal cells, siRNA against SCD in HEK293 cells, co-culture experiments Genetics High 29997234
2019 AdipoR1 and AdipoR2 are essential for sustaining desaturase expression and high levels of unsaturated fatty acids in membrane phospholipids in many human cell types including primary HUVECs. Three independent methods (FRAP, Laurdan dye GP, mass spectrometry of phospholipid FA composition) confirm their role as membrane fluidity regulators. Critically, AdipoRs can prevent lipotoxicity in the complete absence of adiponectin, indicating their primary cellular function is membrane homeostasis independent of adiponectin ligand. AdipoR1/R2 siRNA knockdown in multiple human cell types, FRAP, Laurdan generalized polarization, phospholipid FA composition by mass spectrometry, palmitate challenge Journal of lipid research High 30890562
2019 C. elegans PAQR-2 (AdipoR2 homolog) senses temperature drop and promotes biosynthesis of γ-linolenic acid and arachidonic acid (ω-6 PUFAs), which initiate autophagy in the epidermis, delaying age-dependent collagen decline and extending lifespan at low temperature. C. elegans genetics, lipidomics, autophagy assays, lifespan analysis, epistasis with fatty acid biosynthesis genes Nature communications Medium 31197136
2021 AdipoR2 deficiency causes extensive transcriptome misregulation and membrane defects in cells challenged with saturated fatty acids (SFAs). Transcriptomics and lipidomics showed AdipoR2 responds to membrane rigidification by regulating lipid metabolism genes. AdipoR2 deficiency phenocopies SREBP deficiency upon SFA challenge. Among AdipoR2, SCD, FADS2, PEMT and ACSL4, AdipoR2 and SCD are the most important for preventing membrane rigidification by exogenous SFAs. Transcriptomics, lipidomics, growth and respiration assays, membrane property analyses in HEK293 and HUVEC cells with AdipoR2 KO or knockdown, comparative gene silencing of multiple lipid metabolism genes Biochimica et biophysica acta. Molecular and cell biology of lipids High 33444759
2021 C. elegans forward genetic screen identified that only the PAQR-2/IGLR-2 pathway (homologous to human AdipoR2) is uniquely essential for tolerance to dietary saturated fatty acids. FRET analysis showed that the PAQR-2/IGLR-2 interaction is regulated by membrane fluidity, indicating a membrane fluidity-sensing mechanism. N-terminal truncation of PAQR-2 showed the cytoplasmic domain is dispensable but IGLR-2 interaction remains required. C. elegans whole-organism forward genetic screen, lipidomics, membrane fluidity measurements, FRET-based protein interaction assay, PAQR-2 domain deletion analysis Biochimica et biophysica acta. Molecular and cell biology of lipids High 33444761
2021 AdipoR2 silencing in the presence of exogenous palmitic acid potently increases dihydroceramide levels (ceramide precursor in de novo synthesis), consistent with AdipoR2 silencing increasing intracellular palmitic acid supply driving serine palmitoyl transferase activity. AdipoR2 overexpression caused depletion of dihydroceramides. AdipoR2 siRNA knockdown and overexpression in cultured cells, sphingolipid lipidomics, comparison with SCD and SREBF1/2 silencing Lipids in health and disease Medium 34839823
2022 RNF145 is an E3 ubiquitin ligase that ubiquitinates and promotes degradation of ADIPOR2 in unsaturated lipid membranes. When membranes become enriched in saturated FAs, RNF145 auto-ubiquitinates and is itself degraded, stabilizing ADIPOR2. ADIPOR2 hydrolase activity then restores lipid homeostasis and prevents lipotoxicity. RNF145 and ADIPOR2 form an autoregulatory loop controlling membrane lipid composition. Systematic proteomics identifying differentially expressed proteins with saturated vs. unsaturated FA feeding, ubiquitination assays, RNF145 and ADIPOR2 degradation assays, lipid homeostasis and lipotoxicity assays in mammalian cells The EMBO journal High 35993436
2023 AdipoR2 promotes elongation and incorporation of polyunsaturated fatty acids into phospholipids. Immunoprecipitation of tagged AdipoR2 followed by mass spectrometry identified evolutionarily conserved interactors including the dehydratase HACD3 (essential for fatty acid elongation step 3) and ACSL4 (activates unsaturated FAs for phospholipid incorporation). 13C-labeled FA tracing confirmed AdipoR2 promotes FA elongation. These interactions are functionally verified. Immunoprecipitation of tagged AdipoR2 and PAQR-2 from HEK293 cells and C. elegans followed by mass spectrometry, 13C-labeled fatty acid tracing, functional interaction validation experiments The Journal of biological chemistry High 37164154
2024 AdipoR2 regulates the meiosis-specific lipidome in mouse testes by promoting synthesis of very-long-chain polyunsaturated fatty acids (VLC-PUFAs) in sphingolipids and phospholipids. AdipoR2 upregulates fatty acid elongase ELOVL2 both transcriptionally and post-transcriptionally. AdipoR2 KO testes accumulate palmitic acid and show membrane stiffening, causing nuclear envelope invagination, impaired meiotic telomere peripheral distribution, errors in homologous synapsis and recombination, and defective intercellular bridge formation. AdipoR2 knockout mice, testis lipidomics, ELOVL2 expression analysis (transcriptional and post-transcriptional), nuclear envelope ultrastructure analysis, meiotic telomere distribution assays, synapsis/recombination analysis, germ cell syncytium analysis Nature communications High 38485951
2024 AdipoR2 KO mice have brains with excessive phospholipid saturation (excess palmitic acid at expense of oleic acid in phosphatidylcholines, ~12% increase in saturated FA in PC), consistent with a defect in fatty acid desaturation and elongation. Older AdipoR2 KO mice are hyperactive and anxious, do not gain weight in old age, and have lower cell density in the cerebrum, but have normal lifespans. AdipoR2 KO mice, lipidomics of brain phospholipids at 2/7/18 months, histology, electron microscopy, proteomics, behavioral tests (hyperactivity, anxiety) FASEB journal Medium 38989587
2024 SCM-198 selectively binds AdipoR2 with the R335 residue critical for SCM-198-AdipoR2 binding and Y274 serving as a molecular switch for Ca2+ influx. SCM-198-AdipoR2 binding causes Ca2+ influx and elevates phosphorylation of CaMKII and NOS3 within an identified AdipoR2-CaM-CaMKII-NOS3 complex, rapidly inducing nitric oxide production that protects against acute liver failure. Molecular docking, site-directed mutagenesis of AdipoR2 (R335, Y274 residues), Ca2+ influx measurements, co-immunoprecipitation of AdipoR2-CaM-CaMKII-NOS3 complex, phosphorylation assays, NO production measurement, mouse ALF model, human ESC-derived liver organoids Nature communications High 39681560
2006 Adiponectin downregulates the expression of its own receptor AdipoR2 (but not AdipoR1) both in vivo (transgenic mice overexpressing adiponectin in adipose tissue showed decreased AdipoR2 mRNA) and in vitro (recombinant adiponectin added to 3T3-F442A adipocytes decreased AdipoR2 mRNA). Conversely, AdipoR2 (but not AdipoR1) was specifically upregulated in fat of adiponectin-null mice, establishing a specific negative feedback loop. Transgenic mice with adipose-targeted adiponectin expression, adiponectin-KO mice, 3T3-F442A adipocyte cell culture with recombinant adiponectin, RT-PCR and protein quantification Biochemical and biophysical research communications Medium 16729974
2009 In human granulosa KGN cells, AdipoR2 knockdown reduced progesterone and estradiol production and lower StAR protein levels in response to FSH or IGF-1 stimulation. AdipoR2 knockdown also reduced adiponectin/FSH-induced MAPK ERK1/2 phosphorylation. In contrast, AdipoR1 knockdown caused apoptosis (increased cleaved caspase-3, decreased BAD phosphorylation and PCNA), indicating differential roles: AdipoR1 in cell survival, AdipoR2 in steroid production via ERK1/2. RNAi knockdown of AdipoR1 and AdipoR2 in KGN cells, steroid hormone RIA, western blot for signaling proteins, tritiated thymidine proliferation assay Human reproduction (Oxford, England) Medium 19671624
2010 AdipoR2 signaling in the anterior cingulate cortex (ACC) contributes to alcohol-related behaviors. AdipoR2 expression in the ACC was differentially regulated by alcohol in a K-ras-dependent manner. AdipoR2 null mice showed attenuated withdrawal-associated increased drinking. Adiponectin increased the excitability of ACC neurons, more pronounced during alcohol withdrawal. Gene expression analysis in ACC, AdipoR2 null mice behavioral testing (alcohol drinking), intracellular electrophysiological recordings of ACC neurons during alcohol withdrawal Brain research Medium 20380822
2021 CTRP3 suppresses Th17 cell differentiation via AdipoR2 (but not AdipoR1). Suppression of Th17 differentiation by CTRP3 was abolished by an AdipoR2 receptor antagonist but not an AdipoR1 antagonist, and was associated with suppression of Rorc and Stat3 expression. AdipoRon also suppressed Th17 differentiation via AdipoR2. T cell differentiation assays, AdipoR1/R2 receptor antagonists, C1qtnf3 knockout mice, EAE (experimental autoimmune encephalomyelitis) model, AdipoRon treatment Frontiers in immunology Medium 34925309
2023 Emodin succinate monoethyl ester (ESME) activates AdipoR2 by forming an arene-arene interaction (molecular docking). Fluorescent ESME labels AdipoR2 on the cytomembrane of HepG2 cells. ESME activates AdipoR2, AMPK (via CaMKK2 and LKB1), and PPARα to reduce hepatic lipogenesis. AdipoR2 suppression completely eliminates ESME's lipid-lowering effect. Molecular docking, fluorescent ligand labeling on cell membranes, AdipoR2 siRNA knockdown, AMPK/PPARα signaling assays, lipid accumulation assays, in vivo hamster and mouse models Free radical biology & medicine Medium 37044149
2024 AdipoR2 regulates luteal steroidogenesis specifically through AMPK. APN (1 μg/mL) or AdipoRon (25 μM) increased P-AMPK in goat luteal cells and decreased progesterone (P4) and steroidogenic protein levels (STAR/CYP11A1/HSD3B) after 24h. APN failed to affect P-AMPK, CYP11A1 expression, or P4 levels when AdipoR2 was silenced (SiAdipoR2), while silencing AdipoR1 or T-cadherin did not block this pathway. Primary goat luteal steroidogenic cell culture, AdipoRon and APN treatment, siRNA knockdown of AdipoR1, AdipoR2, and T-cadherin, AMPK phosphorylation and steroidogenic protein western blots, progesterone RIA Cells Medium 37408227

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nature medicine 1117 17268472
2020 AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis. Nature communications 120 33199780
2007 Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2. Cancer science 114 17459059
2006 Expression of adiponectin and its receptors (AdipoR1 and AdipoR2) in chicken ovary: potential role in ovarian steroidogenesis. Domestic animal endocrinology 112 17010558
2008 The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth. Biochemistry 107 18842004
2008 Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice. Hepatology (Baltimore, Md.) 105 18666257
2013 PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. PLoS genetics 104 24068966
2016 Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors. Molecular psychiatry 95 27137743
2016 Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy. Journal of translational medicine 93 27286657
2011 Adiponectin-AdipoR1/2-APPL1 signaling axis suppresses human foam cell formation: differential ability of AdipoR1 and AdipoR2 to regulate inflammatory cytokine responses. Atherosclerosis 78 22227293
2019 Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy. Nature communications 73 31197136
2009 Role of adiponectin receptors, AdipoR1 and AdipoR2, in the steroidogenesis of the human granulosa tumor cell line, KGN. Human reproduction (Oxford, England) 71 19671624
2006 Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice. Biochemical and biophysical research communications 71 16729974
2016 Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition. PLoS genetics 62 27082444
2009 Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. European journal of endocrinology 62 19208777
2008 Adiponectin and its receptors are expressed in the chicken testis: influence of sexual maturation on testicular ADIPOR1 and ADIPOR2 mRNA abundance. Reproduction (Cambridge, England) 62 18660386
2006 Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. Diabetes 62 16505255
2019 AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin. Journal of lipid research 60 30890562
2006 Molecular cloning and tissue expression of chicken AdipoR1 and AdipoR2 complementary deoxyribonucleic acids. Domestic animal endocrinology 60 16697136
2010 ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling. Biochemical and biophysical research communications 57 20074551
2008 Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue. Oncology reports 56 18695895
2009 No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 49 19723917
2017 The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty acids. PLoS genetics 46 28886012
2018 Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease. Clinical and experimental pharmacology & physiology 45 29569260
2014 microRNA-423-3p promotes tumor progression via modulation of AdipoR2 in laryngeal carcinoma. International journal of clinical and experimental pathology 42 25337209
2017 Wogonin mitigates nonalcoholic fatty liver disease via enhancing PPARα/AdipoR2, in vivo and in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 39 28486193
2011 ADIPOQ, ADIPOR1, and ADIPOR2 polymorphisms in relation to serum adiponectin levels and BMI in black and white women. Obesity (Silver Spring, Md.) 39 21273992
2006 Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats. Metabolism: clinical and experimental 39 16483885
2014 Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo. The Journal of biological chemistry 38 24742672
2010 Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes. Cardiovascular diabetology 37 20178558
2008 The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. Human genetics 37 19037660
2013 Expression of adiponectin receptors 1 (AdipoR1) and 2 (AdipoR2) in the porcine pituitary during the oestrous cycle. Reproductive biology and endocrinology : RB&E 36 23497348
2018 Membrane Fluidity Is Regulated Cell Nonautonomously by Caenorhabditiselegans PAQR-2 and Its Mammalian Homolog AdipoR2. Genetics 35 29997234
2010 AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells. The FEBS journal 35 20423458
2018 miR-449a induces EndMT, promotes the development of atherosclerosis by targeting the interaction between AdipoR2 and E-cadherin in Lipid Rafts. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 32 30551487
2014 Expression of adiponectin and adiponectin receptors 1 (AdipoR1) and 2 (AdipoR2) in the porcine uterus during the oestrous cycle. Animal reproduction science 32 24598213
2007 Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance. Obesity reviews : an official journal of the International Association for the Study of Obesity 30 17716299
2017 The role of AdipoR1 and AdipoR2 in liver fibrosis. Biochimica et biophysica acta. Molecular basis of disease 29 29237572
2009 The expression of adiponectin receptors Adipo-R1 and Adipo-R2 is associated with an intestinal histotype and longer survival in gastric carcinoma. Journal of clinical pathology 28 19638541
2009 Downregulation of adiponectin/AdipoR2 is associated with steatohepatitis in obese mice. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 28 19763702
2017 Decreased Adiponectin-Mediated Signaling Through the AdipoR2 Pathway Is Associated With Carotid Plaque Instability. Stroke 25 28258256
2011 Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study. Cardiovascular diabetology 24 21943112
2022 Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2. The EMBO journal 23 35993436
2014 Ginsenoside Rb1 stimulates adiponectin signaling in C2C12 muscle cells through up-regulation of AdipoR1 and AdipoR2 proteins. Pharmaceutical biology 23 25311947
2021 Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids. Biochimica et biophysica acta. Molecular and cell biology of lipids 21 33444759
2021 The C. elegans PAQR-2 and IGLR-2 membrane homeostasis proteins are uniquely essential for tolerating dietary saturated fats. Biochimica et biophysica acta. Molecular and cell biology of lipids 20 33444761
2017 In silico analysis of nonsynonymous single nucleotide polymorphisms of the human adiponectin receptor 2 (ADIPOR2) gene. Computational biology and chemistry 19 28359874
2013 Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: insulin resistance and type 2 diabetes mellitus candidate genes. American journal of therapeutics 19 23656997
2023 AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity. The Journal of biological chemistry 18 37164154
2017 Expression of adiponectin and its receptors (AdipoR1 and AdipoR2) in goat ovary and its effect on oocyte nuclear maturation in vitro. Theriogenology 18 28843075
2010 A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake. Brain research 18 20380822
2021 AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice. Molecules (Basel, Switzerland) 17 34063466
2021 The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation. Frontiers in immunology 17 34925309
2015 Molecular cloning and expression analysis of adiponectin and its receptors (AdipoR1 and AdipoR2) in the hypothalamus of the Huoyan goose during different stages of the egg-laying cycle. Reproductive biology and endocrinology : RB&E 17 26251033
2012 Pioglitazone prevents hyperglycemia induced decrease of AdipoR1 and AdipoR2 in coronary arteries and coronary VSMCs. Molecular and cellular endocrinology 16 22820128
2012 Nutritional and hormonal modulation of adiponectin and its receptors adipoR1 and adipoR2. Vitamins and hormones 16 23017712
2020 Expression and localization of adiponectin and its receptors (AdipoR1 and AdipoR2) in the hypothalamic-pituitary-ovarian axis of laying hens. Theriogenology 15 33113442
2018 Association of Native American ancestry and common variants in ACE, ADIPOR2, MTNR1B, GCK, TCF7L2 and FTO genes with glycemic traits in Colombian population. Gene 15 30063936
2017 Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects. Scientific reports 15 28145500
2024 Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. Nature communications 14 38485951
2023 A novel small molecule AdipoR2 agonist ameliorates experimental hepatic steatosis in hamsters and mice. Free radical biology & medicine 14 37044149
2015 Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoR1 and AdipoR2. Journal of structural and functional genomics 13 25575462
2008 Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans. Clinical endocrinology 13 18466348
2015 ADIPOQ and ADIPOR2 gene polymorphisms: association with overweight/obesity in Mexican children. Boletin medico del Hospital Infantil de Mexico 12 29421176
2020 Sex- and season-dependent differences in the expression of adiponectin and adiponectin receptors (AdipoR1 and AdipoR2) in the hypothalamic-pituitary-adrenal axis of the Eurasian beaver (Castor fiber L.). General and comparative endocrinology 11 32739435
2020 Expression of AdipoR1 and AdipoR2 and Serum Level of Adiponectin in Gastric Cancer. Gastrointestinal tumors 11 33173773
2020 A Potential Theragnostic Regulatory Axis for Arthrofibrosis Involving Adiponectin (ADIPOQ) Receptor 1 and 2 (ADIPOR1 and ADIPOR2), TGFβ1, and Smooth Muscle α-Actin (ACTA2). Journal of clinical medicine 11 33213041
2017 Telmisartan ameliorates adipoR1 and adipoR2 expression via PPAR-γ activation in the coronary artery and VSMCs. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 11 28837879
2017 Expression of AdipoR1 and AdipoR2 Receptors as Leptin-Breast Cancer Regulation Mechanisms. Disease markers 11 29311755
2015 Characterisation of the adiponectin receptors: Differential cell-surface expression and temporal signalling profiles of AdipoR1 and AdipoR2 are regulated by the non-conserved N-terminal trunks. Molecular and cellular endocrinology 11 25892445
2008 Association of ADIPOR2 with liver function tests in type 2 diabetic subjects. Obesity (Silver Spring, Md.) 10 18719649
2024 Uncovering the connection between obesity and thyroid cancer: the therapeutic potential of adiponectin receptor agonist in the AdipoR2-ULK axis. Cell death & disease 9 39349421
2018 Susceptibility of multiple polymorphisms in ADIPOQ, ADIPOR1 and ADIPOR2 genes to myocardial infarction in Han Chinese. Gene 9 29524572
2013 Characterisation of the adiponectin receptors: the non-conserved N-terminal region of AdipoR2 prevents its expression at the cell-surface. Biochemical and biophysical research communications 9 23376713
2023 Distinct roles of ADIPOR1 and ADIPOR2: A pan-cancer analysis. Frontiers in endocrinology 8 36896172
2023 Overexpression of salusin‑α upregulates AdipoR2 and activates the PPARα/ApoA5/SREBP‑1c pathway to inhibit lipid synthesis in HepG2 cells. International journal of molecular medicine 8 37026514
2022 Propofol postconditioning alleviates diabetic myocardial ischemia‑reperfusion injury via the miR‑200c‑3p/AdipoR2/STAT3 signaling pathway. Molecular medicine reports 8 35211763
2021 Palmitic acid causes increased dihydroceramide levels when desaturase expression is directly silenced or indirectly lowered by silencing AdipoR2. Lipids in health and disease 8 34839823
2015 in vitro Anti-Proliferative Effect of Adiponectin on Human Endometriotic Stromal Cells through AdipoR1 and AdipoR2 Gene Receptor Expression. Iranian biomedical journal 8 26459399
2024 Novel role of Quercetin in ameliorating metabolic syndrome via VDR mediated activation of adiponectin/AdipoR2 signaling. Biochemistry and biophysics reports 7 39006943
2023 APN Expression in Serum and Corpus Luteum: Regulation of Luteal Steroidogenesis Is Possibly Dependent on the AdipoR2/AMPK Pathway in Goats. Cells 6 37408227
2021 AdipoR2 inhibits human glioblastoma cell growth through the AMPK/mTOR pathway. European journal of medical research 6 33752745
2015 Revealing the Strong Functional Association of adipor2 and cdh13 with adipoq: A Gene Network Study. Cell biochemistry and biophysics 6 25388841
2024 Aging AdipoR2-deficient mice are hyperactive with enlarged brains excessively rich in saturated fatty acids. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 5 38989587
2021 Crosstalk between AdipoR1/AdipoR2 and Nrf2/HO-1 signal pathways activated by β-caryophyllene suppressed the compound 48/80 induced pseudo-allergic reactions. Clinical and experimental pharmacology & physiology 5 34314522
2015 Adipo-R1 and adipo-R2 expression in colorectal adenomas and carcinomas. Asian Pacific journal of cancer prevention : APJCP 5 25640382
2024 Selectively targeting the AdipoR2-CaM-CaMKII-NOS3 axis by SCM-198 as a rapid-acting therapy for advanced acute liver failure. Nature communications 4 39681560
2020 Age Associated Changes in Transcription of Adiponectin, AdipoR1 and AdipoR2 Genes in Pancreas of Rats. Cell journal 4 32779434
2024 Efficacy of ADIPOR1 and ADIPOR2 peptide-agonist AdipoRon in preventing contracture in a rabbit model of arthrofibrosis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 3 38605593
2016 A Variant in ADIPOR2 Is Associated with Increased Free Fatty Acid Levels in Chinese Population. Metabolic syndrome and related disorders 3 27348122
2022 A small molecule screen for paqr-2 suppressors identifies Tyloxapol as a membrane fluidizer for C. elegans and mammalian cells. Biochimica et biophysica acta. Biomembranes 2 35588889
2016 [Effects of lotus leaf on inflammatory factors and liver AdipoR2 expressions in rats with NAFLD induced by high fat diet and high glucose]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2 28925124
2025 Adiponectin Signaling Ameliorates Cognitive Dysfunction in Type 2 Diabetic Mice by Activating the Hippocampal AdipoR2-PPARα/CREB Pathway. Molecular neurobiology 1 41254427
2024 Reduced hepatic AdipoR2 by increased glucocorticoid mediates effect of psychosocial stress to elevate serum cholesterol. Molecular and cellular endocrinology 1 38815796
2020 Modulation of adiponectin receptors AdipoR1 and AdipoR2 by phage display-derived peptides in in vitro and in vivo models. Journal of drug targeting 1 31888393
2016 [Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 1 27978938
2025 AdipoR2 enhances adipocyte thermogenesis in Tibetan pigs via AMPK-ACC signaling. Journal of thermal biology 0 40645109
2025 Placental mitochondrial respiration is inhibited in mice with trophoblast specific AdipoR2 overexpression. Free radical biology & medicine 0 41265498
2025 Serum cortisol and AdipoR2 rs12342 were involved in the correlation between stress and serum cholesterol in a gender-specific manner. Metabolic brain disease 0 41317243
2023 [Cloning of adipor1 and adipor2 genes in Rana dybowskii and its expression pattern upon infection]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 0 37154335

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