Affinage

CRMP1

Dihydropyrimidinase-related protein 1 · UniProt Q14194

Length
572 aa
Mass
62.2 kDa
Annotated
2026-06-09
36 papers in source corpus 25 papers cited in narrative 24 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CRMP1 is a cytosolic neuronal phosphoprotein that acts as an intracellular effector of Semaphorin 3A (Sema3A) signaling to regulate cytoskeletal remodeling during axon guidance, neurite outgrowth, dendritic development, and neuronal migration (PMID:22378692, PMID:27480924, PMID:33449368). Sema3A-dependent function is gated by sequential phosphorylation: Fyn phosphorylates CRMP1 at Tyr504, an event required for Sema3A-induced growth cone collapse and cortical dendritic development (PMID:33449368), while phosphorylation at Ser522 controls its activity in axonal outgrowth and motor neuron integrity (PMID:35523582, PMID:36237616). Mechanistically, CRMP1 remodels the actin cytoskeleton by binding both the actin-binding domain and a rod immunoglobulin repeat of Filamin-A; phospho-mimicking CRMP1(Ser522Asp) condenses Filamin-A and weakens Filamin-A-crosslinked F-actin gels, displacing Filamin-A to permit remodeling, and it associates with actin and the Arp2/3 activator WAVE1 to restrain stress-fiber and filopodia formation (PMID:25358863, PMID:27321179). CRMP1 also functionally couples with the Nav1.7 sodium channel to drive Sema3A-induced retrograde axonal transport of PlexA4 and TrkA from growth cones (PMID:28254884). Genetically, CRMP1 acts redundantly or synergistically with CRMP2 and CRMP4 in dendritic spine maturation, dendrite orientation, and Purkinje and granule cell migration (PMID:27480924, PMID:27836492, PMID:35219721, PMID:17121542), and its oligomerization is required for neurite outgrowth (PMID:36511780). In cancer, CRMP1 suppresses invasion and EMT by competing with its long isoform LCRMP-1 for WAVE1 binding, with its expression controlled at the promoter by competing C/EBPα and Sp1 and repressed by NF-κB p50 and Snail (PMID:21747164, PMID:27321179, PMID:18524846, PMID:18782567). De novo heterozygous CRMP1 variants that impair oligomerization and suppress neurite outgrowth link the gene to a neurodevelopmental disorder (PMID:36511780).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2002 Medium

    Established the first molecular activity for a CRMP1 splice variant, showing it could modulate Rho-pathway signaling rather than acting as an inert cytoskeletal protein.

    Evidence Co-IP from brain extracts with ROKα, kinase activity assay, and neurite retraction rescue by overexpression

    PMID:12482610

    Open questions at the time
    • Studied a specific p80 splice variant, not necessarily canonical CRMP1
    • ROKα inhibition mechanism not structurally defined
    • Effect shown by overexpression, not loss-of-function
  2. 2005 Medium

    Defined where CRMP1 acts by mapping its predominantly dendritic localization in specific adult neuronal populations.

    Evidence Immunohistochemistry on adult mouse brain and primary cortical neuron cultures

    PMID:15834957

    Open questions at the time
    • Descriptive localization without functional linkage
    • Subcellular compartment resolution limited
  3. 2006 High

    Provided the first genetic evidence that CRMP1 is required in vivo, establishing a developmental role in cerebellar granule cell migration.

    Evidence CRMP1 knockout mice and cerebellar explant migration assay replicated by antibody blockade

    PMID:17121542

    Open questions at the time
    • Molecular effectors downstream of CRMP1 in migration not defined
    • Cell-autonomy not fully resolved
  4. 2008 Medium

    Identified the transcriptional control logic of CRMP1 in cancer, where promoter occupancy dictates invasiveness.

    Evidence EMSA, ChIP, reporter assays, and invasion assays mapping C/EBPα, Sp1, and NF-κB p50 to the CRMP1 promoter

    PMID:18524846 PMID:18782567

    Open questions at the time
    • Links promoter regulation to invasion but not to CRMP1 cytoskeletal mechanism
    • Single lab
  5. 2011 Medium

    Defined CRMP1's tumor-suppressive mechanism as competitive inhibition of its long isoform within the WAVE1/actin nucleation pathway.

    Evidence Co-IP, overexpression in noninvasive cell lines, and filopodia/invasion assays showing CRMP1 disrupts LCRMP-1/WAVE-1 binding

    PMID:21747164

    Open questions at the time
    • Structural basis of isoform competition not resolved
    • Relationship to neuronal WAVE1 function unaddressed
  6. 2012 High

    Resolved CRMP1's spatial role in growth cone dynamics, showing it is locally required for lamellipodial maintenance and directional guidance distinct from CRMP2.

    Evidence Microscale chromophore-assisted light inactivation with spatiotemporal control in live neurons

    PMID:22378692

    Open questions at the time
    • Molecular targets of CRMP1 within the growth cone not identified here
    • Acute inactivation only
  7. 2014 High

    Identified the direct cytoskeletal substrate mechanism: phospho-CRMP1 displaces Filamin-A to enable actin remodeling during Sema3A repulsion.

    Evidence Pulldown, AFM, F-actin gelation assay, alanine mutagenesis, and C. elegans UNC-33/FLN-1 genetics

    PMID:25358863

    Open questions at the time
    • In vivo demonstration of Filamin-A displacement in mammalian neurons limited
    • How phosphorylation triggers binding-mode change not structurally solved
  8. 2014 Medium

    Connected upstream kinase regulation to function, showing Spy1-modulated CDK5 phosphorylation of CRMP1 controls its actin association and regeneration capacity.

    Evidence Yeast two-hybrid, Co-IP, phosphorylation assay, and rat sciatic nerve crush model

    PMID:25526860

    Open questions at the time
    • Specific phosphosite controlling actin association not pinpointed here
    • Single lab
  9. 2017 High

    Revealed a non-cytoskeletal mechanism: CRMP1 couples with Nav1.7 to drive Sema3A-induced retrograde transport of guidance and neurotrophin receptors.

    Evidence crmp1-/- DRG neurons, Nav1.7 RNAi, co-localization, and HEK293 electrophysiology

    PMID:28254884

    Open questions at the time
    • Molecular link between CRMP1/Nav1.7 and the transport machinery undefined
    • Whether channel activity per se is required for transport unresolved
  10. 2021 High

    Identified the tyrosine-phosphorylation arm of CRMP1 regulation, placing Fyn-mediated Tyr504 phosphorylation as a required node for Sema3A responses and dendrite development.

    Evidence In vitro Fyn kinase assay, Tyr504Phe mutagenesis, growth cone collapse, and Fyn;Crmp1 double-heterozygote epistasis

    PMID:33449368

    Open questions at the time
    • Interplay between Tyr504 and Ser522 phosphorylation not defined
    • Downstream effector engaged by phospho-Tyr504 unknown
  11. 2021 Medium

    Extended the growth cone pathway by identifying FEZ1 as a CRMP1 partner whose loss phenocopies CRMP1 deficiency.

    Evidence Co-IP, co-localization, and FEZ1 knockdown with matching morphological readout

    PMID:33771901

    Open questions at the time
    • Directionality of the FEZ1-CRMP1 relationship not firmly established
    • Mechanism of pathway coupling unknown
  12. 2022 High

    Established phospho-state-specific pathology, showing Ser522 phosphorylation drives ALS-relevant motor neuron degeneration while CRMP1 protein itself is protective.

    Evidence Crmp1 Ser522Ala knock-in versus KO in SOD1G93A mice, behavior, histology, and human ALS spinal cord immunostaining

    PMID:35523582 PMID:36237616

    Open questions at the time
    • Kinase responsible for disease-associated Ser522 phosphorylation not pinned down in vivo
    • Link between pCRMP1 spheroids and neurofilament pathology mechanistic detail limited
  13. 2022 Medium

    Demonstrated genetic redundancy among CRMP family members in migration and dendrite patterning, clarifying why single knockouts can be subtle.

    Evidence CRMP1/CRMP2 and CRMP1/CRMP4 double knockout mice with cerebellar and cortical/hippocampal morphology and behavior

    PMID:27480924 PMID:27836492 PMID:35219721

    Open questions at the time
    • Molecular basis of functional redundancy not resolved
    • Whether heterodimerization underlies redundancy untested
  14. 2022 Medium

    Linked CRMP1 to human neurodevelopmental disease and tied disease variants to a specific molecular defect in oligomerization.

    Evidence De novo variant identification, oligomerization assays, and neurite outgrowth assays in cortical neurons

    PMID:36511780

    Open questions at the time
    • How oligomerization controls CRMP1 activity mechanistically unclear
    • Overexpression-based phenotype rather than endogenous
  15. 2023 Medium

    Expanded CRMP1 function into adult synaptic homeostasis, showing it maintains the synaptic/extrasynaptic NMDA receptor balance and limits tau phosphorylation.

    Evidence crmp1 KO mice across ages, biochemical fractionation, and Morris water maze

    PMID:38176125

    Open questions at the time
    • Direct molecular link between CRMP1 and NMDA receptor distribution unknown
    • Single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the distinct CRMP1 phosphorylation events (Tyr504, Ser522) and binding partners (Filamin-A, WAVE1, Nav1.7, FEZ1, LKB1) are integrated into a unified, context-dependent signaling logic remains unresolved.
  • No structural model integrating phospho-states with partner switching
  • Quantitative ordering of Fyn/CDK5/GSK3β phosphorylation events not established
  • Mechanism connecting cytoskeletal and channel-coupled functions unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 3 GO:0008092 cytoskeletal protein binding 2 GO:0060090 molecular adaptor activity 2
Localization
GO:0005856 cytoskeleton 2 GO:0005829 cytosol 1
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-1643685 Disease 4 R-HSA-162582 Signal Transduction 3
Partners
DISC1FEZ1FLNAFYNHTTSCN9ASTK11WASF1

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 p80 CRMP-1 (a novel splice variant of CRMP-1 with an extended N-terminus) was co-immunoprecipitated with ROKα from brain extracts, interacted with the kinase domain of ROKα, and inhibited ROKα catalytic activity toward other substrates. p80 CRMP-1 also formed oligomeric complexes with CRMP-2. Co-overexpression of p80 CRMP-1 and CRMP-2 counteracted RhoA-induced neurite retraction, an effect enhanced by mutation of the ROK phosphorylation site in CRMP-2. Co-immunoprecipitation from brain extracts, peptide mass analysis, kinase activity assay, overexpression in neurons FEBS letters Medium 12482610
2005 CRMP1 localizes predominantly to dendrites of specific adult neuronal populations (cortical pyramidal neurons, hippocampal CA1 pyramidal cells, Purkinje cells) in adult mouse brain, as determined by immunohistochemistry with specific antibodies. In cultures of cortical neurons CRMP1 is distributed throughout cell bodies, axons, and dendrites. Immunohistochemistry with specific antibodies on adult mouse brain sections and primary neuron cultures The Journal of comparative neurology Medium 15834957
2006 CRMP1 is required for normal granule cell migration, proliferation, and apoptosis during postnatal cerebellar development. CRMP1-/- mice showed reduced granule cell migration from cerebellar explants, and anti-CRMP1 antibody treatment of wild-type explants replicated this defect. CRMP1 knockout mice (knock-in LacZ), cerebellar explant migration assay, antibody blockade, in vivo histology Genes to cells : devoted to molecular & cellular mechanisms High 17121542
2006 CRMP-1 was identified as a binding partner of GNE (UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase), the key enzyme of sialic acid biosynthesis, via yeast two-hybrid screening followed by co-immunoprecipitation verification. Yeast two-hybrid assay, co-immunoprecipitation FEBS letters Low 17118363
2008 NF-κB p50 (but not the classic p65/p50 heterodimer) binds to a κB site in the CRMP-1 promoter region (between -1753 and -1743) and negatively regulates CRMP-1 expression, thereby promoting cancer cell invasion. Antisense p50 increased CRMP-1 protein level and decreased invasiveness. EMSA, supershift assay, ChIP, antisense p50 transfection, invasion assay Biochemical and biophysical research communications Medium 18782567
2008 Transcription of CRMP-1 is reciprocally regulated at its promoter by C/EBPα (activator) and Sp1 (repressor) competing for overlapping binding sites (-122 to -133 and -101 to -113). COX-2 overexpression decreases CRMP-1 expression by promoting Sp1 binding; COX-2 inhibitor celecoxib increases CRMP-1 expression by reducing Sp1-DNA complex formation and enhancing C/EBPα binding. Serial deletion, site-directed mutagenesis, EMSA, antibody supershift, ChIP, luciferase reporter, overexpression Molecular cancer therapeutics Medium 18524846
2011 CRMP-1 associates with LCRMP-1 (long isoform of CRMP-1) and disrupts the interaction between LCRMP-1 and WAVE-1, thereby inhibiting LCRMP-1-mediated filopodia formation, actin stabilization, and cancer cell invasion. LCRMP-1 acts downstream of Cdc42 in the WAVE-1/actin nucleation pathway, and CRMP-1 antagonizes this pathway by competing for LCRMP-1 binding. Co-immunoprecipitation, overexpression in noninvasive cell lines, filopodia/invasion assays, WAVE-1 interaction assays The Journal of clinical investigation Medium 21747164
2012 CRMP1 was identified as insoluble/misfolded protein in post-mortem schizophrenia brains and shown to directly and functionally interact with DISC1 (Disrupted-in-schizophrenia 1), placing CRMP1 at the intersection of reelin and DISC1 pathways. Antibodies against pooled insoluble proteome, biochemical fractionation of post-mortem brains, functional interaction assay with DISC1 Human molecular genetics Low 22798627
2012 Local inactivation of CRMP1 (by micro-CALI) in the central domain of the growth cone caused lamellipodial retraction and subsequent retardation of neurite outgrowth, whereas inactivation in the neurite shaft arrested neurite outgrowth. Focal inactivation of CRMP1 in one half of the growth cone caused the growth cone to turn away from the irradiated site. These effects were distinct from those of CRMP2 inactivation. Microscale chromophore-assisted light inactivation (micro-CALI) with spatial and temporal resolution in live neurons Developmental neurobiology High 22378692
2012 CRMP1 and CRMP2 have synergistic roles in Sema3A-dependent dendritic spine maturation. crmp1-/- mice showed reduced dendritic spine density in cortical layer V pyramidal neurons comparable to sema3A-/- and crmp2-/- mice. CRMP1 levels increased in crmp2-/- mice, but there was no genetic interaction between crmp1 and crmp2 on spine density (double heterozygous sema3A+/-;crmp1+/- showed reduced spine density and branching). CRMP2 and CRMP1 knockout mice, dendritic spine density quantification, genetic epistasis analysis Genes to cells : devoted to molecular & cellular mechanisms High 27480924
2014 CRMP1 binds both the actin-binding domain and the last immunoglobulin-like repeat (rod 24) of Filamin-A. Phosphorylation-mimicking CRMP1(Ser522Asp) enhances Sema3A repulsion in neurons and causes Filamin-A to adopt a condensed form (shown by atomic-force microscopy). Phospho-CRMP1(Ser522Asp) weakens F-actin gelation crosslinked by Filamin-A, suggesting phosphorylated CRMP1 displaces Filamin-A from the actin cytoskeleton to facilitate remodeling. Alanine mutants in the interacting residues of either Filamin-A or CRMP1 suppress Sema3A repulsion. The C. elegans homologue UNC-33 (CRMP1) interacts with FLN-1 (Filamin-A orthologue) and participates in motor neuron projection. Pulldown, co-immunoprecipitation, atomic-force microscopy, alanine mutagenesis, F-actin gelation assay, C. elegans genetics Nature communications High 25358863
2014 CRMP1 interacts with Speedy A1 (Spy1), a member of the Speedy/RINGO family, as identified by yeast two-hybrid and verified by co-immunoprecipitation. Spy1 modulates CDK5-mediated phosphorylation of CRMP1. Enhanced CRMP1 phosphorylation (promoted by Spy1) disturbs the association of CRMP1 with actin, contributing to abnormal Sema3A-induced growth cone collapse and impaired regeneration after sciatic nerve crush. Yeast two-hybrid, co-immunoprecipitation, overexpression/shRNA knockdown, phosphorylation assay, rat sciatic nerve crush model Molecular neurobiology Medium 25526860
2015 CRMP1 directly interacts with N-terminal huntingtin (HTT) fragments containing expanded polyglutamine tracts and suppresses their spontaneous self-assembly into proteotoxic aggregates, reducing HTT misfolding and neurotoxicity in multiple HD models. Protein-protein interaction network filtering, experimental validation of CRMP1-HTT interaction in HD models (cell and in vivo) Genome research Medium 25908449
2016 CRMP1 suppresses EMT and metastasis in prostate cancer cells by associating with actin and WAVE1 (an Arp2/3 activator). CRMP1 knockdown stabilizes F-actin and triggers stress fiber formation; overexpression inhibits EMT and in vivo metastasis. CRMP1 expression is suppressed by histone deacetylation and direct promoter repression by the EMT regulator Snail. Co-immunoprecipitation (CRMP1-actin and CRMP1-WAVE1), siRNA knockdown, stable overexpression, F-actin staining, in vivo metastasis assay, ChIP for Snail binding to CRMP1 promoter Oncogene Medium 27321179
2016 CRMP1 and CRMP4 redundantly regulate proper orientation of basal dendrites of layer V pyramidal neurons and apical dendrite bifurcation of hippocampal CA1 neurons. CRMP1/CRMP4 double knockout showed severe dendritic orientation abnormalities not seen in single knockouts. CRMP1 and CRMP4 single and double knockout mice, cortical and hippocampal neuron morphology analysis Brain research Medium 27836492
2017 CRMP1 functionally couples with Nav1.7 (SCN9A) to mediate Sema3A-induced retrograde axonal transport of PlexA4 and TrkA from growth cones. In crmp1-/- DRG neurons, Sema3A-induced co-localization and retrograde transport of PlexA4 and TrkA were impaired (similar to Nav1.7 RNAi knockdown). Sema3A induced co-localization of CRMP1 and Nav1.7 in growth cones. Introduction of CRMP1 in HEK293 cells lowered the activation threshold of co-expressed Nav1.7. crmp1-/- mouse DRG neurons, RNAi knockdown of Nav1.7, immunofluorescence co-localization, electrophysiology in HEK293 cells Journal of cell science High 28254884
2021 Fyn kinase phosphorylates CRMP1 at Tyrosine 504 (Tyr504), and this phosphorylation is required for Sema3A-induced growth cone collapse and dendritic development. CRMP1-Tyr504Phe mutant suppressed Sema3A-induced growth cone collapse in DRG and hippocampal neurons and impaired cortical dendritic development in vivo. Fyn+/-;Crmp1+/- double heterozygous mice showed poor basal dendrite development similar to Sema3a-/-, Fyn-/-, and Crmp1-/- mice. In vitro kinase assay (Fyn phosphorylating CRMP1 Tyr504), site-directed mutagenesis (Tyr504Phe), growth cone collapse assay, in vivo cortical neuron morphology, double heterozygous genetic epistasis Journal of neurochemistry High 33449368
2021 FEZ1 interacts with CRMP1 at neuronal growth cones. FEZ1 deficiency in hippocampal neurons caused growth cone collapse and impaired axonal development phenotypically similar to CRMP1 loss-of-function, placing FEZ1 upstream or in the same pathway as CRMP1 in growth cone guidance. Co-immunoprecipitation, immunofluorescence co-localization, FEZ1 knockdown with morphological readout, comparison to CRMP1 loss-of-function eNeuro Medium 33771901
2022 Inhibition of CRMP1 phosphorylation at Ser522 (using Crmp1S522A knock-in mice) improved motor function and preserved motor neurons and neuromuscular junctions in SOD1G93A ALS model mice, whereas CRMP1 knockout worsened outcomes. Phospho-mimicking CRMP1 mutant overexpression inhibited axonal outgrowth in Neuro2A cells. Phosphorylated CRMP1 (pCRMP1) accumulates in spheroids in ALS patient spinal cords and co-localizes with phosphorylated neurofilaments. Crmp1 Ser522Ala knock-in and CRMP1 KO mice in SOD1G93A background, rotarod test, motor neuron/NMJ histology, phosphoproteomic identification, phospho-mimicking mutant overexpression, human ALS patient immunostaining eNeuro / Frontiers in neurology High 35523582 36237616
2022 De novo heterozygous variants in CRMP1 impair CRMP1 oligomerization and suppress neurite outgrowth in murine cortical neurons upon overexpression, linking CRMP1 oligomerization to its role in neurite development. In silico structural analysis, oligomerization assay, neurite outgrowth assay in primary cortical neurons with overexpression of variants eLife Medium 36511780
2022 CRMP1 and CRMP2 redundantly regulate migration and positioning of Purkinje cells in cerebellar lobule X. CRMP1/CRMP2 double knockout mice showed deficits in Purkinje cell migration and alignment in lobule X and impaired performance on the balance beam test. CRMP1/CRMP2 double knockout mice, cerebellar histology, balance beam and grip power tests Brain research Medium 35219721
2022 CRMP1 is expressed in cochlear outer and inner hair cells, and its deletion causes progressive high-frequency hearing loss and hair cell loss at the basal cochlear region without affecting hair cell morphogenesis. Immunostaining, Crmp1 knockout mice, scanning electron microscopy, auditory brainstem response testing The American journal of pathology Medium 35181334
2023 LKB1 physically interacts with CRMP1 (co-immunoprecipitation) in regenerated sciatic nerve axons, and LKB1 regulates CRMP1 phosphorylation. Overexpression of both LKB1 and CRMP1 promotes Schwann cell invasion/migration and neuronal process extension; knockdown of CRMP1 abolishes LKB1's nerve repair-promoting function. Co-immunoprecipitation, immunofluorescence co-localization, overexpression and siRNA knockdown, Schwann cell invasion assay, rat sciatic nerve crush model Developmental neurobiology Medium 38105470
2023 Deletion of CRMP1 in mice disrupts the balance between synaptic and extrasynaptic NMDA receptors in the hippocampus, increasing extrasynaptic NMDA receptor levels and tau phosphorylation, leading to synaptic and neuronal loss in CA3 and accelerated age-related cognitive decline. crmp1 KO mice at adult/middle-aged/older stages, Morris water maze, biochemical fractionation for synaptic/extrasynaptic NMDA receptor levels, glutamate/glutamine measurement Neurobiology of aging Medium 38176125

Source papers

Stage 0 corpus · 36 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain. The Journal of comparative neurology 93 15834957
2011 The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1. The Journal of clinical investigation 66 21747164
2012 Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits. Human molecular genetics 59 22798627
2016 CRMP1 and CRMP2 have synergistic but distinct roles in dendritic development. Genes to cells : devoted to molecular & cellular mechanisms 51 27480924
2006 Transient alterations in granule cell proliferation, apoptosis and migration in postnatal developing cerebellum of CRMP1-/- mice. Genes to cells : devoted to molecular & cellular mechanisms 43 17121542
2002 p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology. FEBS letters 42 12482610
2016 Collapsin response mediator protein-1 (CRMP1) acts as an invasion and metastasis suppressor of prostate cancer via its suppression of epithelial-mesenchymal transition and remodeling of actin cytoskeleton organization. Oncogene 41 27321179
2014 Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling. Nature communications 41 25358863
2012 Localized role of CRMP1 and CRMP2 in neurite outgrowth and growth cone steering. Developmental neurobiology 41 22378692
2006 The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis. FEBS letters 35 17118363
2014 CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush. Molecular neurobiology 21 25526860
2008 NF-kappaB p50 promotes tumor cell invasion through negative regulation of invasion suppressor gene CRMP-1 in human lung adenocarcinoma cells. Biochemical and biophysical research communications 21 18782567
2015 Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity. Genome research 20 25908449
2008 Modulation of the expression of the invasion-suppressor CRMP-1 by cyclooxygenase-2 inhibition via reciprocal regulation of Sp1 and C/EBPalpha. Molecular cancer therapeutics 15 18524846
2021 FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development. eNeuro 14 33771901
2018 Lithium-associated transcriptional regulation of CRMP1 in patient-derived olfactory neurons and symptom changes in bipolar disorder. Translational psychiatry 13 29666369
2016 MicroRNA-187 regulates gastric cancer progression by targeting the tumor suppressor CRMP1. Biochemical and biophysical research communications 13 27864146
2017 A functional coupling between CRMP1 and Nav1.7 for retrograde propagation of Semaphorin3A signaling. Journal of cell science 12 28254884
2016 CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain. Brain research 12 27836492
2012 Down-regulation of CRMP-1 in patients with epilepsy and a rat model. Neurochemical research 11 22359051
1998 Genomic organization and localization of the human CRMP-1 gene. DNA research : an international journal for rapid publication of reports on genes and genomes 11 10048489
2022 Inhibition of Crmp1 Phosphorylation at Ser522 Ameliorates Motor Function and Neuronal Pathology in Amyotrophic Lateral Sclerosis Model Mice. eNeuro 10 35523582
2022 Monoallelic CRMP1 gene variants cause neurodevelopmental disorder. eLife 10 36511780
2021 Phosphorylation of Collapsin Response Mediator Protein 1 (CRMP1) at Tyrosine 504 residue regulates Semaphorin 3A-induced cortical dendritic growth. Journal of neurochemistry 9 33449368
2023 Establishing an objective clinical spectrum, genotype-phenotype correlations, and CRMP1 as a modifier in the Ellis-van Creveld syndrome: The first systematic review of EVC- and EVC2-associated conditions. Genetics in medicine open 8 39669252
2015 CRMP1 Inhibits Proliferation of Medulloblastoma and Is Regulated by HMGA1. PloS one 7 26009886
2023 Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in mice. Neurobiology of aging 6 38176125
2022 Requirement of CRMP2 Phosphorylation in Neuronal Migration of Developing Mouse Cerebral Cortex and Hippocampus and Redundant Roles of CRMP1 and CRMP4. Cerebral cortex (New York, N.Y. : 1991) 6 34297816
2020 Phosphorylation of CRMP2 is required for migration and positioning of Purkinje cells: Redundant roles of CRMP1 and CRMP4. Brain research 6 32156571
2022 Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis. Frontiers in neurology 5 36237616
2022 Loss of CRMP1 and CRMP2 results in migration defects of Purkinje cells in the X lobule of the mouse cerebellum. Brain research 4 35219721
2023 LKB1 and CRMP1 cooperatively promote the repair of the sciatic nerve injury. Developmental neurobiology 2 38105470
2022 Collapsin Response Mediator Protein 1 (CRMP1) Is Required for High-Frequency Hearing. The American journal of pathology 2 35181334
2008 Abnormal expression of truncated CRMP-1 protein in the brain cortex of MPSIIIB mice. Molecular genetics and metabolism 1 18325808
2004 Haplotype and linkage disequilibrium analysis of the CRMP1 and EVC genes. International journal of molecular medicine 1 15492864
2024 Case report: A de novo variant of CRMP1 in an individual with a neurodevelopmental disorder. Frontiers in neuroscience 0 39758889

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