Affinage

CREBZF

CREB/ATF bZIP transcription factor · UniProt Q9NS37

Length
354 aa
Mass
37.1 kDa
Annotated
2026-06-09
100 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CREBZF (Zhangfei/SMILE) is a bZIP transcriptional co-regulator that broadly restrains stress-, growth-, and metabolism-associated transcription factors through direct protein-protein contacts rather than autonomous DNA binding (PMID:31469186, PMID:29637572). In liver, it constrains regeneration by binding the linker domain of STAT3 to block its dimerization and downstream cyclin expression (PMID:31469186), and it couples insulin signaling to lipogenesis by associating with ATF4 to repress Insig-2a, thereby licensing SREBP-1c-driven fatty acid synthesis (PMID:29637572); it further drives diet-induced fibrosis through a hepatocyte-autonomous axis in which it suppresses miR-6964-3p to elevate osteopontin secretion and activate hepatic stellate cells (PMID:36680394). In adipose tissue CREBZF associates with PGC-1α to repress thermogenic genes including UCP1, and its abundance is set by reversible Lys208 acetylation written by CBP/p300 and erased by HDAC3 that gates proteasomal turnover (PMID:38588421). It governs proteostasis by binding the UPR effector Xbp1s via its leucine zipper and targeting it for proteasomal degradation (PMID:24155933), and it stabilizes p53 by displacing Mdm2 and acting through its bZIP/bLZip domain, cooperating with HEY1 to potentiate p53-dependent transcription and p53-dependent growth suppression (PMID:22983008, PMID:24200963). CREBZF additionally inhibits BMP signaling through interaction with R-Smads 1/5/8 (PMID:22707059) and supports steroidogenesis by upregulating the nuclear receptors Nr4a1 and Nr5a1 in Leydig cells (PMID:31124138). Its own expression is induced by amino acid deprivation via an AARE-like promoter element (PMID:20026304).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2009 Medium

    Established how CREBZF transcription itself is controlled, placing it within the amino acid stress response.

    Evidence Promoter deletion mapping and site-directed mutagenesis of an AARE-like element under amino acid deprivation in MDCK cells

    PMID:20026304

    Open questions at the time
    • Transcription factor binding the AARE-like element not identified
    • Single study without independent replication
  2. 2012 Medium

    Identified CREBZF as a positive regulator of p53 and a partner of HEY1, framing it as a stabilizer rather than activator-by-DNA-binding.

    Evidence Yeast two-hybrid (HEY1 bait), in vitro binding, Co-IP, p53 reporter assays and siRNA knockdown

    PMID:22983008

    Open questions at the time
    • Identity of the protective post-translational modifications on p53 not defined
    • Largely in vitro/overexpression context
  3. 2012 Medium

    Defined CREBZF as a BMP-pathway repressor through direct R-Smad binding, broadening its co-repressor scope.

    Evidence Yeast two-hybrid (Smad8 MH2 bait), Co-IP in prostate cancer cells, BMP-response element reporter and BMP-6 growth assay

    PMID:22707059

    Open questions at the time
    • Mechanism of Smad inhibition not resolved
    • In vivo relevance untested
  4. 2013 High

    Resolved the p53 stabilization mechanism as Mdm2 displacement requiring the bLZip domain, and showed p53 is the obligate intermediary for growth and UPR effects.

    Evidence Co-IP, nuclear co-localization imaging, Mdm2 displacement assay, bLZip deletion mutants and isogenic p53-null vs p53-expressing cell comparison

    PMID:24200963

    Open questions at the time
    • Does not define which post-translational modifications block degradation
    • p53-independent CREBZF functions not addressed
  5. 2013 High

    Showed CREBZF restrains the UPR directly by degrading Xbp1s, defining a leucine-zipper-dependent proteostasis brake distinct from the p53 axis.

    Evidence Co-IP, leucine zipper deletion mutants, UPR reporter assays and siRNA knockdown in primary rat sensory neurons

    PMID:24155933

    Open questions at the time
    • E3 ligase mediating Xbp1s degradation not identified
    • Relationship to the p53-dependent UPR effects unresolved
  6. 2013 Medium

    Linked CREBZF to estrogen-regulated uterine biology and blastocyst-dependent expression at implantation.

    Evidence IHC, western blot, RT-PCR across pregnancy stages, ovariectomy/hormone rescue and delayed implantation models in mice

    PMID:24325733

    Open questions at the time
    • Functional role in implantation not tested by loss-of-function
    • Downstream targets in uterine epithelium unknown
  7. 2015 Medium

    Confirmed p53-dependent growth suppression, UPR repression and differentiation across multiple independent cell lines, strengthening the p53-coupled tumor-suppressive model.

    Evidence Adenoviral Zhangfei expression in four canine osteosarcoma lines, RT-PCR, growth and apoptosis assays

    PMID:25890299

    Open questions at the time
    • Overexpression-based with limited mechanistic depth
    • Differentiation pathway to osteocalcin induction not mapped
  8. 2018 High

    Defined the in vivo metabolic role of CREBZF as coupling insulin-Akt signaling to hepatic lipogenesis via ATF4-dependent Insig-2a repression.

    Evidence Liver-specific knockout mice, refeeding/insulin models, ATF4 Co-IP, promoter/reporter assays

    PMID:29637572

    Open questions at the time
    • How insulin signaling regulates CREBZF activity not defined
    • Direct DNA contact at Insig-2a vs ATF4-mediated recruitment not distinguished
  9. 2018 Medium

    Showed CREBZF can promote apoptosis and autophagy and modulate ERK/mTOR signaling in granulosa cells, extending its pro-death activity to the ovary.

    Evidence Overexpression/knockdown, flow cytometry, phospho-western blots and LC3-II in mouse ovarian granulosa cells

    PMID:30413092

    Open questions at the time
    • Mechanism connecting CREBZF to ERK/mTOR not defined
    • Single lab, overexpression-weighted
  10. 2019 Medium

    Placed CREBZF as a positive driver of Leydig cell steroidogenesis acting through Nr4a1/Nr5a1.

    Evidence Lentiviral shRNA, primary Leydig and MLTC-1 cells, intratesticular microinjection, testosterone radioimmunoassay, RT-PCR

    PMID:31124138

    Open questions at the time
    • Direct vs indirect control of Nr4a1/Nr5a1 unresolved
    • In vivo fertility consequence not tested here
  11. 2020 High

    Established CREBZF as a brake on liver regeneration by directly inhibiting STAT3 dimerization, with a pharmacological rescue confirming the axis.

    Evidence Liver-specific KO mice, reciprocal Co-IP, AAV overexpression, cell-cycle flow cytometry and STAT3 inhibitor rescue in two injury models

    PMID:31469186

    Open questions at the time
    • Structural basis of linker-domain binding not solved
    • Signals controlling CREBZF during regeneration unknown
  12. 2023 High

    Defined a hepatocyte-autonomous CREBZF→osteopontin→stellate cell axis driving NASH fibrosis through miR-6964-3p suppression.

    Evidence Diet-induced NASH models, liver-specific KO, AAV osteopontin rescue, miRNA manipulation and HSC activation assays

    PMID:36680394

    Open questions at the time
    • How CREBZF represses miR-6964-3p not defined
    • Relationship to its lipogenic role in the same tissue unintegrated
  13. 2023 Medium

    Embedded the CREBZF-STAT3 axis in a circPAPD4/miR-1269a/ADAR1 feedback loop constraining breast cancer progression.

    Evidence RNA pull-down, dual-luciferase reporters, Co-IP, in vivo CREBZF mRNA nanoparticle delivery and ADAR1 manipulation

    PMID:37264406

    Open questions at the time
    • Directness of CREBZF effect on ADAR1 expression unclear
    • Single lab
  14. 2023 Medium

    Linked CREBZF to oocyte transcriptional competence and aging via a miR-425-5p axis affecting H3K4me3 methyltransferase regulation.

    Evidence miRNA-seq, microinjection of miR-425-5p inhibitors, in vivo antagomir, single-cell RNA-seq and Crebzf manipulation in oocytes

    PMID:37532927

    Open questions at the time
    • Direct targets through which CREBZF controls H3K4me3 enzymes not defined
    • Single lab
  15. 2024 High

    Identified glucose-induced CREBZF as a thermogenic suppressor acting through PGC-1α, with Lys208 acetylation as the stability switch governing its abundance.

    Evidence Adipose-specific KO mice, Lys208 mutagenesis, CBP/p300 and HDAC3 Co-IP, cold exposure and PGC-1α co-factor pulldown

    PMID:38588421

    Open questions at the time
    • Whether acetylation control generalizes to other CREBZF functions untested
    • Direct PGC-1α binding interface not mapped
  16. 2024 Medium

    Refined the steroidogenic role using cell-type-specific knockout, revealing intrinsic Leydig defects and adrenal/behavioral consequences despite preserved fertility.

    Evidence Cyp17a1-Cre conditional KO, primary Leydig cell testosterone ELISA, RT-PCR, adrenal IHC and behavioral testing

    PMID:38696238

    Open questions at the time
    • Mechanism linking CREBZF loss to adrenal cortex thickening unknown
    • Cause of anxiety/memory phenotype not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how a single bZIP co-regulator selects among its many partners (STAT3, ATF4, Xbp1s, p53, R-Smads, PGC-1α) in a tissue- and signal-specific manner, and what structural determinants and post-translational switches dictate each interaction.
  • No structural model of any CREBZF-partner interface
  • Logic of partner selection across tissues undefined
  • Whether CREBZF binds DNA directly at any target remains unestablished

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0140110 transcription regulator activity 4
Localization
GO:0005634 nucleus 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1430728 Metabolism 2 R-HSA-392499 Metabolism of proteins 2 R-HSA-8953897 Cellular responses to stimuli 2
Partners
ATF4HEY1MDM2PPARGC1ASMAD8STAT3TP53XBP1

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2020 CREBZF associates with the linker domain of STAT3 and represses STAT3 dimerization and transcriptional activity, thereby inhibiting cyclin gene expression and liver regeneration after partial hepatectomy and CCl4-induced injury. Hepatocyte-specific CREBZF knockout hyperactivates STAT3-driven cyclin D1 and regeneration, which is reversed by the STAT3 inhibitor cucurbitacin I. Liver-specific knockout mice, co-immunoprecipitation, adeno-associated virus overexpression, flow cytometry cell cycle analysis, STAT3 inhibitor rescue experiment Hepatology High 31469186
2018 CREBZF couples insulin-Akt signaling to hepatic lipogenesis by directly inhibiting transcription of Insig-2a through association with ATF4, thereby allowing SREBP-1c processing and de novo fatty acid synthesis. Liver-specific CREBZF knockout induces Insig-2a and Insig-1 and represses the lipogenic program during refeeding and in streptozotocin/insulin-treated mice. Liver-specific knockout mice, refeeding and insulin treatment models, co-immunoprecipitation with ATF4, reporter/promoter assays, western blot for Insig isoforms and lipogenic enzymes Hepatology High 29637572
2023 CREBZF promotes osteopontin production and secretion in hepatocytes by inhibiting miR-6964-3p, which in turn activates hepatic stellate cells (HSCs) and drives liver fibrosis in diet-induced NASH. AAV-mediated osteopontin rescue in CREBZF-deficient mice restores HSC activation and NASH progression, establishing a hepatocyte-autonomous CREBZF→osteopontin→HSC axis. Diet-induced NASH mouse models, CREBZF liver-specific knockout, AAV-mediated osteopontin rescue, miRNA manipulation, HSC activation assays Hepatology High 36680394
2024 Glucose induces CREBZF in white adipose tissue, where it associates with PGC-1α to repress thermogenic gene expression (including UCP1). Lys208 acetylation by CBP/p300 and deacetylation by HDAC3 regulates CREBZF protein stability by controlling proteasomal degradation. Adipose-specific CREBZF knockout mice show enhanced browning, thermogenic gene expression, and adaptive thermogenesis during cold exposure. Adipose-specific CREBZF knockout mice, acetylation site mutagenesis (Lys208), CBP/p300 and HDAC3 co-immunoprecipitation, cold exposure assays, rectal temperature measurement, chromatin/co-factor pulldown with PGC-1α Proceedings of the National Academy of Sciences of the United States of America High 38588421
2013 CREBZF/Zhangfei interacts with Xbp1s via its leucine zipper domain, leading to proteasomal degradation of Xbp1s. This suppresses Xbp1s-driven transcription from UPR elements and reduces UPR gene expression. siRNA knockdown of endogenous Zhangfei in thapsigargin-treated primary rat sensory neurons significantly increases UPR transcripts and proteins. Co-immunoprecipitation, leucine zipper deletion mutants, UPR reporter assays, siRNA knockdown in primary neurons, western blot and RT-PCR for UPR markers PloS one High 24155933
2012 CREBZF is a novel positive regulator of p53: it interacts in vitro with both HEY1 and p53, stabilizes p53 protein, activates p53 transcriptional activity, and cooperates synergistically with HEY1 to enhance p53-dependent transcription. CREBZF induces post-translational modifications on p53 that prevent its degradation. Partial knockdown of endogenous CREBZF diminishes p53 protein levels and inhibits HEY1-mediated p53 activation. Yeast two-hybrid screen (HEY1 as bait), in vitro binding assays, co-immunoprecipitation, p53 reporter assays, siRNA knockdown, post-translational modification analysis Cell cycle Medium 22983008
2013 The effects of Zhangfei/CREBZF on cell growth suppression and UPR inhibition require the tumor suppressor p53 as an intermediary. The bLZip domain of Zhangfei is required for interaction with p53. Zhangfei stabilizes p53 and co-localizes with it in cellular nuclei, and displaces the E3 ubiquitin ligase Mdm2 from its association with p53. siRNA suppression of p53 partially inhibits Zhangfei's effects. Zhangfei has no effect on p53-null MG63 cells but mirrors its D-17 effects in p53-expressing U2OS cells. Co-immunoprecipitation, nuclear co-localization by imaging, Mdm2 displacement assay, siRNA knockdown of p53, bLZip domain deletion mutants, p53-null cell line comparison Cell cycle High 24200963
2012 CREBZF interacts with Smads 1, 5, and 8 (BMP-pathway R-Smads), identified through yeast two-hybrid screening using the MH2 domain of Smad8 as bait, confirmed by co-immunoprecipitation in a human prostate cancer cell line. Overexpression of CREBZF inhibits BMP response element promoter activity and abolishes BMP-6-induced cell growth inhibition. Yeast two-hybrid screen (Smad8 MH2 domain as bait), co-immunoprecipitation in human prostate cancer cells, BMP-response element reporter assay, BMP-6 cell growth inhibition assay Molecular and cellular biochemistry Medium 22707059
2019 CREBZF promotes hCG-induced testosterone production in mouse Leydig cells by upregulating the orphan nuclear receptors Nr4a1 and Nr5a1, which subsequently drive expression of steroidogenic genes (3β-HSD, 17β-HSD, P450c17). CREBZF silencing in primary Leydig cells and MLTC-1 cells significantly inhibits hCG-stimulated testosterone production and reduces serum testosterone after lentiviral shRNA microinjection into mouse testis. Lentiviral shRNA knockdown, primary Leydig cell culture, MLTC-1 cell overexpression/knockdown, intratesticular microinjection, testosterone radioimmunoassay, RT-PCR for steroidogenic genes and nuclear receptors Journal of cellular physiology Medium 31124138
2018 CREBZF overexpression induces apoptosis in mouse ovarian granulosa cells by upregulating BAX and cleaved Caspase-3, downregulating BCL-2, and inhibiting ERK1/2 and mTOR signaling pathways (reduced phosphorylation of ERK1/2 and S6K1). CREBZF also activates autophagy (increased LC3-II). CREBZF overexpression and knockdown, flow cytometry for apoptosis, western blot for apoptosis markers and pathway phosphoproteins, LC3-II autophagy marker International journal of molecular sciences Medium 30413092
2012 Zhangfei/CREBZF induces cell death in ONS-76 medulloblastoma cells through a mechanism involving enhanced transcription from the Brn3a promoter, subsequent TrkA upregulation, and autocrine NGF-TrkA signaling that activates the MAPK pathway, leading to differentiation and cell death. Antibodies against NGF and inhibitors of TrkA and MAPK components partially restore growth of Zhangfei-expressing cells. Adenoviral Zhangfei expression, Brn3a promoter reporter assay, NGF antibody neutralization, TrkA and MAPK inhibitors, transcript profiling, phosphorylation-based kinase activity analysis Journal of neuro-oncology Medium 22798206
2009 CREBZF/Zhangfei expression is induced by amino acid deprivation in MDCK cells. A 9-bp AARE-like element (5'-ATTCACTCA-3') at position -1227 to -1219 in the CREBZF promoter is required for amino acid deprivation-inducible transcription, identified by deletion mapping and site-directed mutagenesis. Amino acid deprivation in MDCK cells, CREBZF promoter cloning, deletion mapping and site-directed mutagenesis, promoter-reporter assays Biochemical and biophysical research communications Medium 20026304
2013 CREBZF (SMILE isoform) is expressed in mouse uterine luminal and glandular epithelium, is regulated by estrogen (oestrogen stimulates SMILE expression in ovariectomized mice), and its expression peaks on day 4 of pregnancy at implantation sites but is absent from decidual cells. The presence of an active blastocyst is required for SMILE expression at the implantation site. Immunohistochemistry, western blot, RT-PCR across pregnancy stages, ovariectomy/hormone treatment, pseudopregnancy model, delayed implantation model Reproductive biology and endocrinology Medium 24325733
2023 miR-425-5p suppresses Crebzf expression in aging oocytes. Inhibition of miR-425-5p improves old oocyte development by restoring Crebzf levels. Crebzf regulates mRNAs targeting H3K4me3 histone methyltransferases, acting as a mediator of transcriptional regulation in GV oocytes. Overexpression of miR-425-5p hinders oocyte maturation by downregulating Crebzf and disrupting transcriptional regulation. High-throughput miRNA sequencing, microinjection of miR-425-5p inhibitors, in vivo antagomir treatment, single-cell RNA sequencing, Crebzf overexpression/knockdown in oocytes GeroScience Medium 37532927
2023 CREBZF suppresses STAT3 dimerization and ADAR1 expression, which promotes circPAPD4 biogenesis (since ADAR1 suppresses circPAPD4 formation). CircPAPD4 competitively binds miR-1269a to de-repress CREBZF expression, forming a positive feedback loop (circPAPD4/miR-1269a/CREBZF/STAT3/ADAR1) that curbs breast cancer progression. RNA pull-down, dual-luciferase reporter assays, co-immunoprecipitation, RT-qPCR, in vivo tumor models with CREBZF mRNA nanoparticles, ADAR1 knockdown/overexpression Journal of experimental & clinical cancer research Medium 37264406
2024 Conditional knockout of CREBZF in androgen-synthesis cells (Cyp17a1-Cre) in mice does not affect fertility or serum testosterone, but impairs testosterone secretion in isolated primary Leydig cells and decreases Star, Cyp17a1, and Hsd3b1 mRNA. CREBZF deficiency results in adrenal cortex thickening, elevated serum corticosterone and DHEA, increased StAR/Cyp11a1/17β-Hsd3 in adrenal cortex, and anxiety-like behavior and memory impairment. Cyp17a1-Cre conditional knockout, primary Leydig cell isolation, testosterone ELISA, RT-PCR for steroidogenic genes, immunohistochemistry for adrenal cortex markers, elevated plus maze and Barnes maze behavioral tests FASEB journal Medium 38696238
2015 Zhangfei/CREBZF suppresses cell growth and UPR-related transcripts in multiple independent canine osteosarcoma cell lines (Abrams, McKinley, Gracie, D-17) that express functional p53. Zhangfei also induces osteocalcin expression (a marker of osteoblast differentiation) and triggers programmed cell death in these lines. Effects depend on p53 functionality. Adenoviral Zhangfei expression in four independent OS cell lines, RT-PCR for UPR transcripts and osteocalcin, cell growth assays, apoptosis markers BMC veterinary research Medium 25890299

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1991 Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis. Development (Cambridge, England) 419 1811936
2006 POZ for effect--POZ-ZF transcription factors in cancer and development. Trends in cell biology 216 16996269
1991 Zebrafish pax[zf-a]: a paired box-containing gene expressed in the neural tube. The EMBO journal 201 1718739
2013 ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Biochemical Society transactions 180 23697932
2012 The BTB-ZF transcription factors. Cell cycle (Georgetown, Tex.) 108 22894929
2014 The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity. The Journal of experimental medicine 90 24711583
2012 BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Nature 88 23086144
2011 The BTB-ZF family of transcription factors: key regulators of lineage commitment and effector function development in the immune system. Journal of immunology (Baltimore, Md. : 1950) 79 21900183
2015 BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs. Proceedings of the National Academy of Sciences of the United States of America 61 25605927
2016 APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress. Proceedings of the National Academy of Sciences of the United States of America 54 28028224
2020 CREBZF as a Key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice. Hepatology (Baltimore, Md.) 47 31469186
2002 Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity. The Journal of biological chemistry 47 12021275
2015 Genome-wide analysis and expression patterns of ZF-HD transcription factors under different developmental tissues and abiotic stresses in Chinese cabbage. Molecular genetics and genomics : MGG 46 26546019
2018 Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice. Hepatology (Baltimore, Md.) 45 29637572
1999 RIN ZF, a novel zinc finger gene, encodes proteins that bind to the CACC element of the gastrin promoter. The Journal of biological chemistry 42 10075714
2013 CpG island chromatin is shaped by recruitment of ZF-CxxC proteins. Cold Spring Harbor perspectives in biology 35 24186071
1995 The zebrafish Zf-Sox 19 protein: a novel member of the Sox family which reveals highly conserved motifs outside of the DNA-binding domain. Gene 33 7875601
2019 Genome-wide investigation of the ZF-HD gene family in Tartary buckwheat (Fagopyrum tataricum). BMC plant biology 32 31185913
2014 BTB-ZF transcription factors, a growing family of regulators of early and late B-cell development. Immunology and cell biology 31 24638067
2012 The transcription factor CREBZF is a novel positive regulator of p53. Cell cycle (Georgetown, Tex.) 31 22983008
2011 Interaction identification of Zif268 and TATA(ZF) proteins with GC-/AT-rich DNA sequence: A theoretical study. Journal of computational chemistry 30 20658568
1988 Primary structure, developmentally regulated expression and potential duplication of the zebrafish homeobox gene ZF-21. Nucleic acids research 30 2902580
2018 Dancing from bottoms up - Roles of the POZ-ZF transcription factor Kaiso in Cancer. Biochimica et biophysica acta. Reviews on cancer 29 30419310
2018 Toxicity induced by glyphosate and glyphosate-based herbicides in the zebrafish hepatocyte cell line (ZF-L). Ecotoxicology and environmental safety 27 29990732
2016 The C2H2-ZF transcription factor Zfp335 recognizes two consensus motifs using separate zinc finger arrays. Genes & development 24 27401554
2019 Environmental chemicals differentially affect epigenetic-related mechanisms in the zebrafish liver (ZF-L) cell line and in zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands) 23 31442592
2021 Identification and Transcriptional Analysis of Zinc Finger-Homeodomain (ZF-HD) Family Genes in Cucumber. Biochemical genetics 21 33554320
2010 A novel zf-MYND protein, CHB-3, mediates guanylyl cyclase localization to sensory cilia and controls body size of Caenorhabditis elegans. PLoS genetics 21 21124861
2007 The use of primary hepatocytes from brown trout (Salmo trutta lacustris) and the fish cell lines RTH-149 and ZF-L for in vitro screening of (anti)estrogenic activity of wood extractives. Toxicology in vitro : an international journal published in association with BIBRA 21 18206344
2015 Identification of C2H2-ZF binding preferences from ChIP-seq data using RCADE. Bioinformatics (Oxford, England) 20 25953800
2014 CxxC-ZF domain is needed for KDM2A to demethylate histone in rDNA promoter in response to starvation. Cell structure and function 18 24553073
2014 Construction and expression of lentiviral vectors encoding recombinant mouse CREBZF in NIH 3T3 cells. Plasmid 18 25195838
2013 The POZ-ZF transcription factor Kaiso (ZBTB33) induces inflammation and progenitor cell differentiation in the murine intestine. PloS one 18 24040197
2013 Zhangfei/CREB-ZF - a potential regulator of the unfolded protein response. PloS one 18 24155933
2018 Activation of CREBZF Increases Cell Apoptosis in Mouse Ovarian Granulosa Cells by Regulating the ERK1/2 and mTOR Signaling Pathways. International journal of molecular sciences 17 30413092
2015 The effect of Zhangfei/CREBZF on cell growth, differentiation, apoptosis, migration, and the unfolded protein response in several canine osteosarcoma cell lines. BMC veterinary research 17 25890299
2015 Cytotoxicity of the association of pesticides Roundup Transorb® and Furadan 350 SC® on the zebrafish cell line, ZF-L. Toxicology in vitro : an international journal published in association with BIBRA 17 26065625
2012 Mechanism for the induction of cell death in ONS-76 medulloblastoma cells by Zhangfei/CREB-ZF. Journal of neuro-oncology 17 22798206
2023 CREBZF mRNA nanoparticles suppress breast cancer progression through a positive feedback loop boosted by circPAPD4. Journal of experimental & clinical cancer research : CR 16 37264406
2023 In silico and computational analysis of zinc finger motif-associated homeodomain (ZF-HD) family genes in chilli (Capsicum annuum L). BMC genomics 16 37821819
2022 Up-regulation of long noncoding RNA MBNL1-AS1 suppresses breast cancer progression by modulating miR-423-5p/CREBZF axis. Bioengineered 16 35094653
2020 miRNAs as potential biomarkers for the progression of gastric cancer inhibit CREBZF and regulate migration of gastric adenocarcinoma cells. International journal of medical sciences 16 32218690
2019 Modulation of the multixenobiotic resistance mechanism in Danio rerio hepatocyte culture (ZF-L) after exposure to glyphosate and Roundup®. Chemosphere 16 31029961
2020 Biochemical and genotoxic biomarkers and cell cycle assessment in the zebrafish liver (ZF-L) cell line exposed to the novel metal-insecticide magnesium-hespiridin complex. Chemosphere 15 32380589
2013 CREBZF expression and hormonal regulation in the mouse uterus. Reproductive biology and endocrinology : RB&E 15 24325733
2009 Amino acid deprivation induces CREBZF/Zhangfei expression via an AARE-like element in the promoter. Biochemical and biophysical research communications 15 20026304
2023 Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression. Hepatology (Baltimore, Md.) 14 36680394
2013 Effects of cyclic AMP response element binding protein-Zhangfei (CREBZF) on the unfolded protein response and cell growth are exerted through the tumor suppressor p53. Cell cycle (Georgetown, Tex.) 14 24200963
1993 Chemical assay for cyst(e)ine-rich peptides detects a novel intestinal peptide ZF-1, homologous to a single zinc-finger motif. European journal of biochemistry 14 8425549
2023 Diverse indole-diterpenoids with protein tyrosine phosphatase 1B inhibitory activities from the marine coral-derived fungus Aspergillus sp. ZF-104. Phytochemistry 13 37839588
2019 ZF-Mapper: Simple and Complete Freeware for Fluorescence Quantification in Zebrafish Images. Zebrafish 13 30855222
2019 CREBZF regulates testosterone production in mouse Leydig cells. Journal of cellular physiology 13 31124138
2022 Genome-wide investigation of the ZF-HD gene family in two varieties of alfalfa (Medicago sativa L.) and its expression pattern under alkaline stress. BMC genomics 12 35189832
2012 CREBZF, a novel Smad8-binding protein. Molecular and cellular biochemistry 11 22707059
2006 Nuclear trafficking of the POZ-ZF protein Znf131. Biochimica et biophysica acta 11 17306895
1992 The zebrafish homeobox gene hox[zf-114]: primary structure, expression pattern and evolutionary aspects. The International journal of developmental biology 11 1356006
2023 Genome-wide identification and expression analysis of the ZF-HD gene family in pea (Pisum sativum L.). Frontiers in genetics 10 36685917
2022 Genome-wide analysis of zinc finger-homeodomain (ZF-HD) transcription factors in diploid and tetraploid cotton. Functional & integrative genomics 10 36369302
2024 The BTB-ZF gene Bm-mamo regulates pigmentation in silkworm caterpillars. eLife 9 38587455
2015 BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and Mature T Cells. Journal of immunology (Baltimore, Md. : 1950) 9 26136427
2024 Glucose regulation of adipose tissue browning by CBP/p300- and HDAC3-mediated reversible acetylation of CREBZF. Proceedings of the National Academy of Sciences of the United States of America 8 38588421
2020 On the prediction of DNA-binding preferences of C2H2-ZF domains using structural models: application on human CTCF. NAR genomics and bioinformatics 8 33575598
2017 The POZ-ZF transcription factor Znf131 is implicated as a regulator of Kaiso-mediated biological processes. Biochemical and biophysical research communications 8 28882591
2012 The BTB/POZ-ZF transcription factor dPLZF is involved in Ras/ERK signaling during Drosophila wing development. Molecules and cells 8 22544070
2023 MiR-425-5p suppression of Crebzf regulates oocyte aging via chromatin modification. GeroScience 7 37532927
2023 Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20. Life science alliance 6 37414528
2019 Mitochondrial and lysosomal dysfunction induced by the novel metal-insecticide [Mg(hesp)2(phen)] in the zebrafish (Danio rerio) hepatocyte cell line (ZF-L). Chemico-biological interactions 6 31071334
2015 Identification and characterization of reproductive KRAB-ZF genes in mice. Gene 6 25827285
2023 Genome-Wide Identification and Analysis of ZF-HD Gene Family in Moso Bamboo (Phyllostachys edulis). Plants (Basel, Switzerland) 5 38068699
2018 Genetically engineered zebrafish liver (ZF-L) cells as an in vitro source for zebrafish acetylcholinesterase (zfAChE) for the use in AChE inhibition assays. Toxicology in vitro : an international journal published in association with BIBRA 5 29870745
2004 Phage display of the Equine arteritis virus nsp1 ZF domain and examination of its metal interactions. Journal of virological methods 5 15158598
2000 Effects of cellular mediator agonists on cortisol and steroid acute regulatory (StAR) protein in bovine zona fasciculata (ZF) cells. Endocrine research 5 11196436
2024 DNA-binding proteins from MBD through ZF to BEN: recognition of cytosine methylation status by one arginine with two conformations. Nucleic acids research 4 39329271
2016 Who knows not where an anemone does wear his sting? Could polypeptides released from the columnar vesicles of Bunodosoma cangicum induce apoptosis in the ZF-L cell line? Toxicon : official journal of the International Society on Toxinology 4 27794434
2003 Transcriptional and translational regulation of zebrafish connexin 55.5 (zf.Cx.55.5) and connexin 52.6 (zf.Cx52.6). Cell communication & adhesion 4 14681021
2024 Molecular characterization of cassava zinc finger-homeodomain (ZF-HD) transcription factors reveals their role in disease resistance. International journal of biological macromolecules 3 39179062
2022 Milk of Cow and Goat, Immunized by Recombinant Protein Vaccine ZF-UZ-VAC2001(Zifivax), Contains Neutralizing Antibodies Against SARS-CoV-2 and Remains Active After Standard Milk Pasteurization. Frontiers in nutrition 3 35789966
2022 Structure of the pre-mRNA leakage 39-kDa protein reveals a single domain of integrated zf-C3HC and Rsm1 modules. Scientific reports 3 36271106
2019 Functional analysis of Cwc24 ZF-domain in 5' splice site selection. Nucleic acids research 3 31504764
2018 Regulation of Cyclic AMP-Response Element Binding Protein Zhangfei (CREBZF) Expression by Estrogen in Mouse Uterus. Development & reproduction 3 29707688
2018 A BTB-ZF protein, ZNF131, is required for early B cell development. Biochemical and biophysical research communications 3 29750959
2010 Molecular characterization and expression of the MYND-ZF gene from Clonorchis sinensis. Parasitology research 3 20680338
2003 [Cloning, genomic organization and promoter activity of the mouse zinc finger protein gene ZF-12]. Yi chuan xue bao = Acta genetica Sinica 3 12812053
2025 The members of zinc finger-homeodomain (ZF-HD) transcription factors are associated with abiotic stresses in soybean: insights from genomics and expression analysis. BMC plant biology 2 39810081
2025 Genome-wide identification and expression analysis of ZF-HD family in sunflower (Helianthus annuus L.) under drought and salt stresses. BMC plant biology 2 39894816
2024 Improved treatment of coking wastewater and higher biodiversity through immobilization of Comamonas sp. ZF-3 supplemented microbial community. FEMS microbiology letters 2 39516047
2024 ZF-HD gene family in rapeseed (Brassica napus L.): genome-wide identification, phylogeny, evolutionary expansion and expression analyses. BMC genomics 2 39639240
2020 Identification and effect of Zf-AD-containing C2H2 zinc finger genes on BmNPV replication in the silkworm (Bombyx mori). Pesticide biochemistry and physiology 2 32980066
2019 Shaping of Drosophila Neural Cell Lineages Through Coordination of Cell Proliferation and Cell Fate by the BTB-ZF Transcription Factor Tramtrack-69. Genetics 2 31073020
2018 Differential Expression of Cyclic AMP-Response Element Binding Protein Zhangfei (CREBZF) in the Mouse Testis during Postnatal Development. Development & reproduction 2 29707685
2026 Genome-Wide Identification of the ZF-HD Gene Family in Melon and Functional Characterization of CmZHD8 in Salt Stress Tolerance. Plants (Basel, Switzerland) 1 41754257
2024 Androgen synthesis cell-specific CREBZF deficiency alters adrenal cortex steroid secretion and develops behavioral abnormalities in adult male mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 38696238
2023 Disruption of a BTB-ZF transcription factor causes female sterility and melanization in the larval body of the silkworm, Bombyx mori. Insect biochemistry and molecular biology 1 37356736
2008 Zf-and-Hsys-based Cm measurement under the whole-cell patch-clamp recording. Pflugers Archiv : European journal of physiology 1 19048285
2026 Genome-Wide Identification of the Zinc Finger-Homeodomain (ZF-HD) Gene Family and Their Response to Cold Stress in Rosa chinensis. Genes 0 41595509
2026 African Swine Fever Virus R238L and R298L Disrupt Lung Cell Collagen Formation and Cell Adhesion Pathway by Targeting Transcription Factors Containing zf-C2H2 Domain. Veterinary sciences 0 41893653
2026 The ZF-HD1/9 targets CdSQS to promote squalene biosynthesis in Camellia drupifera. Journal of experimental botany 0 42095833
2025 DeepBovC2H2-ZF: deep learning-guided prediction and molecular dynamics validation of C2H2 zinc finger transcription factors in Bovidae. Journal, genetic engineering & biotechnology 0 41386884
2002 [Establishment of mouse ZF-12+/- embryonic stem cells]. Yi chuan xue bao = Acta genetica Sinica 0 12561468
2002 [Cloning and identification of a mouse zinc finger protein gene ZF-12-related pseudogene]. Shi yan sheng wu xue bao 0 15344332

Missed literature

Know a paper Affinage missed for CREBZF? Flag it for the maintainers and the community.

No submissions yet.