Affinage

CNIH2

Protein cornichon homolog 2 · UniProt Q6PI25

Length
160 aa
Mass
18.9 kDa
Annotated
2026-06-09
38 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CNIH2 is a transmembrane AMPA receptor (AMPAR) auxiliary subunit that controls the assembly, surface delivery, and gating kinetics of hippocampal glutamate receptors while retaining an ancestral role as a COPII-dependent ER-to-Golgi cargo exporter (PMID:21172611, PMID:22292017). In neurons it physically associates with AMPAR complexes in a TARP-γ8-dependent manner, and its surface expression and stability depend on γ-8: CNIH2 protein is depleted in γ-8 knockout mice, and in Purkinje neurons lacking surface γ-8 it fails to reach the membrane, explaining region-specific modulation (PMID:21172611, PMID:21543622). CNIH2 and the related CNIH3 are required for synaptic expression of GluA1-containing heteromers; their conditional deletion profoundly reduces AMPAR transmission and selectively removes surface GluA1-containing receptors (PMID:23522044). Functionally, CNIH2 slows AMPAR deactivation and desensitization, alters channel conductance, calcium permeability and pharmacology, and acts as the molecular determinant of slow versus fast EPSC kinetics at individual synapses, with effects that depend on TARP isoform composition and that can be antagonized by GSG1L (PMID:22815494, PMID:24853943, PMID:22211840, PMID:26932439). Cryo-EM of native and reconstituted GluA1-GluA2 complexes places two CNIH2 subunits at defined A'/C' positions beneath the ligand-binding domains, where a uniquely extended M2 helix mediates gating modulation and the subunit pivots toward the pore exit upon activation (PMID:33981040, PMID:34079129). Binding and gating modulation are dissociable functions mapped to conserved membrane-proximal residues and a CNIH2/3-specific extracellular loop, and CNIH2 additionally enhances AMPAR tetramerization and stability through transmembrane-domain contacts (PMID:25186755, PMID:37673338). Beyond AMPARs, CNIH2 functions as a conserved cargo receptor: it facilitates HB-EGF secretion to spatially confine signaling during neural crest patterning (PMID:17229890), and it supports plasma-membrane targeting of the Na+/H+ antiporter NHA2 (PMID:41676957).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2007 Medium

    Established CNIH2 as a secretory cargo regulator in vivo before its neuronal role was known, showing it confines a growth-factor signal to spatial domains during development.

    Evidence Truncated CNIL expression and siRNA knockdown in chick embryos with cell-culture HB-EGF secretion assays

    PMID:17229890

    Open questions at the time
    • Mechanism of cargo selectivity not defined
    • Relationship to AMPAR role not addressed
    • Single ortholog/system
  2. 2010 High

    Identified CNIH2 as a native AMPAR-associated protein that works with TARP γ-8 to set hippocampal receptor pharmacology and gating, answering whether CNIH2 is a bona fide neuronal auxiliary subunit.

    Evidence Co-IP from hippocampal postsynaptic densities, γ-8 knockout mice, and patch-clamp electrophysiology in recombinant and native systems

    PMID:21172611

    Open questions at the time
    • Stoichiometry within the complex unresolved
    • Structural basis of gating modulation unknown
  3. 2011 High

    Resolved how CNIH2 reaches the neuronal surface and competes with TARPs, showing γ-8-dependent surface access and reduced TARP stoichiometry, and that modulation depends on which TARP isoform is present.

    Evidence Tandem GluA/TARP stoichiometry-constrained electrophysiology, surface biotinylation in hippocampal vs cerebellar neurons, radioligand binding ([3H]-LY450295)

    PMID:21343286 PMID:21543622 PMID:22211840

    Open questions at the time
    • Physical positions of subunits not directly visualized
    • Allosteric coupling between drug sites inferred pharmacologically
  4. 2012 High

    Defined the dual identity of CNIH2 as an ancestral COPII cargo exporter co-opted as an AMPAR subunit, and quantified its gating effects across AMPAR subtypes.

    Evidence ER/Golgi fractionation and COPII transport assays in heterologous cells and neurons; whole-cell and single-channel electrophysiology in tsA201 cells and OPCs

    PMID:22292017 PMID:22815494

    Open questions at the time
    • Cargo repertoire beyond GluA subunits unmapped
    • How surface recruitment overrides ER cycling unclear
  5. 2013 High

    Demonstrated that CNIH2/3 are obligatory for surface and synaptic GluA1-containing AMPARs, and that γ-8 gates which subunits CNIHs can associate with, defining their physiological necessity.

    Evidence CNIH-2/-3 conditional knockout mice with synaptic recordings, surface biotinylation, immunoprecipitation; developmental expression profiling by WB/qRT-PCR/co-IP

    PMID:23403072 PMID:23522044

    Open questions at the time
    • Residual GluA2A3 pool regulation not fully explained
    • Trigger for developmental shift from cargo role to auxiliary role unknown
  6. 2014 High

    Showed CNIH2 is the molecular switch for synaptic EPSC kinetics and mapped the binding versus gating determinants to distinct CNIH2/3-specific residues, separating its two functions.

    Evidence Paired recordings at identified hippocampal synapses with cell-type-specific KD/OE; peptide arrays, mutagenesis, single-particle EM, co-IP

    PMID:24853943 PMID:25186755

    Open questions at the time
    • Atomic-resolution contact geometry not yet defined
    • How extracellular-loop contacts translate to channel gating unresolved
  7. 2016 Medium

    Placed CNIH2 within a network of antagonistic and modulatory auxiliary factors, showing GSG1L opposes its gating effect and PORCN sustains its incorporation via γ-8.

    Evidence Heterologous co-expression electrophysiology with GSG1L; PORCN knockdown in hippocampal neurons with co-IP and electrophysiology

    PMID:26776514 PMID:26932439

    Open questions at the time
    • Direct GSG1L–CNIH2 structural relationship unknown
    • How PORCN biochemically stabilizes the complex unclear
  8. 2018 Medium

    Linked CNIH2 to a specific scaffold-dependent regulatory pathway, showing SAP102 but not PSD-95 acts on AMPARs through CNIH2.

    Evidence Molecular replacement of SAP102/PSD-95 with CNIH-2 knockdown and whole-cell EPSC recordings

    PMID:30067114

    Open questions at the time
    • Mechanism connecting SAP102 to CNIH2 unknown
    • Single-lab epistasis
  9. 2021 High

    Provided the structural basis for CNIH2 action, defining its non-stochastic A'/C' positions, the extended M2 helix that drives gating, and its activation-coupled pivot toward the pore.

    Evidence Cryo-EM of native and recombinant GluA1-GluA2/TARP-γ8/CNIH2 complexes in resting and active states, single-molecule fluorescence, mutagenesis

    PMID:33981040 PMID:34079129

    Open questions at the time
    • Conformational dynamics of the pivot during gating cycle inferred from static states
    • Role of specific lipids not functionally dissected in neurons
  10. 2023 Medium

    Established a distinct biochemical contribution of CNIH2, showing it promotes AMPAR tetramerization and stability via transmembrane contacts independent of gating.

    Evidence Blue native PAGE tetramerization assays, surface biotinylation, transmembrane-domain mutagenesis in heterologous cells

    PMID:37673338

    Open questions at the time
    • Whether tetramerization role operates in native neurons untested
    • Subunit-specific differences with CNIH3 mechanistically unexplained
  11. 2024 Medium

    Identified post-transcriptional control of CNIH2 protein levels, showing alternative polyadenylation and miRNA targeting set its abundance with consequences for tumorigenicity.

    Evidence Iso-Seq/RNA-seq, CPSF3 KD/OE, luciferase reporters, proliferation/migration assays, and xenograft tumor growth in nude mice

    PMID:38718887

    Open questions at the time
    • CNIH2 effector mechanism in carcinoma cells undefined
    • Link to its neuronal/cargo functions unclear
  12. 2025 Medium

    Connected CNIH2 to synaptic plasticity, showing dendritic local translation of CNIH2 selectively enables GluA2-containing AMPAR insertion during LTP.

    Evidence FISH for dendritic mRNA, puromycin local-translation assay, chemical LTP with subtype-specific surface insertion (preprint)

    PMID:bio_10.1101_2025.02.08.637220

    Open questions at the time
    • Not yet peer-reviewed
    • Signaling that triggers local CNIH2 synthesis unknown
    • GluA2-selectivity mechanism not defined
  13. 2026 Low

    Extended CNIH2's cargo-receptor repertoire beyond AMPARs by identifying the Na+/H+ antiporter NHA2 as a cargo via Erv14-like COPII function.

    Evidence Yeast (Erv14-replacement) complementation, plasma-membrane targeting assays, AlphaFold3 modeling of CNIH-Sec24 interactions

    PMID:41676957

    Open questions at the time
    • Heterologous yeast system, not validated in mammalian cells
    • Direct CNIH2-Sec24 interaction computational only
    • NHA2 cargo role single lab

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CNIH2 toggles between its ancestral COPII cargo-export function and its surface AMPAR-gating role, and what signals govern this developmental and activity-dependent switch, remains unresolved.
  • No unified model linking cargo cycling and surface auxiliary roles
  • Triggers for activity-dependent local synthesis undefined
  • Full mammalian cargo repertoire unmapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 6 GO:0038024 cargo receptor activity 3
Localization
GO:0005886 plasma membrane 4 GO:0005783 endoplasmic reticulum 1 GO:0005794 Golgi apparatus 1
Pathway
R-HSA-112316 Neuronal System 3 R-HSA-9609507 Protein localization 3 R-HSA-5653656 Vesicle-mediated transport 1
Partners
CACNG8CNIH3GRIA1GRIA2GSG1LNHA2PORCNPRRT1
Complex memberships
GluA1-GluA2/TARP-γ8/CNIH2 AMPAR complex

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 CNIH-2 associates with TARP γ-8 in hippocampal postsynaptic densities, and CNIH-2 protein levels are markedly diminished in γ-8 knockout mice. CNIH-2 abrogates γ-8-mediated AMPAR resensitization and modifies AMPAR pharmacology and gating to match hippocampal neurons. Manipulating neuronal CNIH-2 levels modulates electrophysiological properties of extrasynaptic and synaptic γ-8-containing AMPA receptors. Co-immunoprecipitation from hippocampal postsynaptic densities, γ-8 knockout mouse analysis, recombinant expression electrophysiology, neuronal CNIH-2 knockdown/overexpression with patch-clamp recordings Neuron High 21172611
2013 CNIH-2 and CNIH-3 are required for synaptic expression of GluA1-containing AMPARs (GluA1A2 heteromers) in hippocampus. Conditional knockout of CNIH-2/-3 causes profound reduction of AMPAR synaptic transmission with selective loss of surface GluA1-containing AMPARs, leaving a residual pool of GluA2A3 heteromers with faster kinetics. TARP γ-8 prevents functional association of CNIHs with non-GluA1 subunits. CNIH-2 and CNIH-3 conditional knockout mice, electrophysiology (synaptic recordings), surface biotinylation, immunoprecipitation Neuron High 23522044
2021 Cryo-EM structure of native hippocampal GluA1-GluA2 AMPAR complexes shows TARP-γ8 and CNIH2-SynDIG4 are non-stochastically positioned at distinct sites (B'/D' and A'/C' positions respectively) within the receptor complex. CNIH2 and TARP-γ8 stoichiometry explains mechanism of submaximal inhibition by a brain-region-specific allosteric inhibitor. Immunoaffinity purification of native hippocampal AMPAR complexes, single-molecule fluorescence, cryo-electron microscopy Nature High 33981040
2021 Cryo-EM structures of GluA1-GluA2 assembled with both TARP-γ8 and CNIH2 in resting and active states reveal two TARP-γ8 and two CNIH2 subunits insert at distinct sites beneath ligand-binding domains. CNIH2 achieves gating modulation through a uniquely extended M2 helix. Upon receptor activation, CNIH2 pivots toward the pore exit extending its reach to cytoplasmic receptor elements. Site-specific lipids shape each auxiliary subunit interaction and affect gating regulation. Cryo-electron microscopy of recombinant GluA1-GluA2/TARP-γ8/CNIH2 complexes in resting and active states, mutagenesis Nature High 34079129
2012 CNIH-2 functions as an evolutionarily conserved cargo exporter from the endoplasmic reticulum, cycling between ER and Golgi in a COPII-dependent manner. GluA subunits recruit CNIH-2 to the cell surface, commandeering its ancestral ER-export role as a bona fide auxiliary subunit that modifies receptor signaling. Heterologous cell expression, ER/Golgi fractionation, COPII-dependent transport assays, primary rat neuron studies PloS one Medium 22292017
2012 CNIH-2 and CNIH-3 (but not CNIH-1) slow deactivation and desensitization of both GluA2-containing calcium-impermeable and GluA2-lacking calcium-permeable AMPARs. CNIH-2/-3 also enhance glutamate sensitivity, single-channel conductance, and calcium permeability of CP-AMPARs while decreasing their block by intracellular polyamines. CNIH-3 overexpression in oligodendrocyte precursor cells markedly slows AMPAR desensitization. Whole-cell patch clamp in tsA201 cells, single-channel recordings, CNIH-3 overexpression in rat optic nerve OPCs, anti-CNIH-2/3 antibody surface labeling The Journal of neuroscience High 22815494
2011 CNIH-2 coexpressed with GluA/TARP complexes reduces TARP stoichiometry within AMPA receptors. In hippocampal neurons, CNIH-2 associates with AMPARs on the neuronal surface in a γ-8-dependent manner to dictate receptor pharmacology. In Purkinje neurons lacking γ-8 surface expression, CNIH-2 does not reach the neuronal surface, explaining region-specific modulation. Tandem GluA/TARP construct electrophysiology to constrain stoichiometry, surface biotinylation in hippocampal and cerebellar neurons, recombinant expression assays The Journal of neuroscience High 21543622
2011 CNIH-2 modulation of AMPAR gating depends on the TARP isoform composition: with γ-8 (hippocampal TARP), CNIH-2 slows deactivation kinetics, increases cyclothiazide potency, and occludes resensitization; with γ-2 (cerebellar TARP), CNIH-2 has minimal effect on deactivation and recovery from desensitization. Electrophysiology in heterologous expression system with defined GluA/TARP/CNIH-2 combinations, pharmacological assays The European journal of neuroscience Medium 22211840
2011 CNIH-2 coexpression confers partial sensitivity of the AMPAR potentiator [(3)H]-LY450295 binding to displacement by non-competitive antagonists, demonstrating that CNIH-2 allosterically links potentiator and antagonist sites on the AMPAR complex. Radioligand binding assay [(3)H]-LY450295, autoradiography in brain sections, recombinant expression with CNIH-2 The Journal of biological chemistry Medium 21343286
2014 CNIH-2 knockdown in hilar mossy cell synapses markedly accelerates EPSC decay without altering amplitude, while CNIH-2 expression in aspiny interneurons (which normally lack CNIH-2) slows their rapidly decaying EPSCs, establishing CNIH-2 as the molecular determinant of slow vs. fast EPSC phenotypes at individual hippocampal synapses. Paired electrophysiological recordings at identified MFB–mossy cell and MFB–interneuron synapses, selective CNIH-2 knockdown and virus-directed overexpression Neuron High 24853943
2014 Peptide array screening and mutagenesis identified two clusters of conserved membrane-proximal residues in CNIHs that mediate direct AMPAR binding. Residues in the extracellular loop of CNIH-2/3 (absent in CNIH-1/4) are critical for both AMPAR interaction and gating modulation. The AMPAR ligand-binding domain and a linker connecting it to the fourth membrane-spanning segment is the principal contact point with the CNIH-3 extracellular loop. A CNIH-3 mutant was identified that preserves AMPAR binding but has attenuated gating modulation, demonstrating binding and gating modulation are dissociable. Peptide array screening, in vitro mutagenesis, single-particle electron microscopy, co-immunoprecipitation, electrophysiology The Journal of neuroscience High 25186755
2007 CNIH2 (CNIL) facilitates the secretion of HB-EGF in chick embryos; perturbation of CNIL function disrupts cranial neural crest cell distribution and results in abnormal nerve fiber connections similar to ErbB4 knockout phenotype. CNIH2 confines HB-EGF action to rhombomeres 3 and 5. Forced expression of truncated CNIL in chick embryos, siRNA knockdown of CNIL or HB-EGF, cell culture secretion assays Molecular biology of the cell Medium 17229890
2016 GSG1L association with AMPARs inhibits CNIH2-induced slowing of AMPAR deactivation/desensitization in heterologous cells, establishing that GSG1L and CNIH2 have opposing effects on AMPAR gating and can functionally antagonize each other within the same receptor complex. Heterologous cell electrophysiology with co-expression of GSG1L and CNIH2, co-immunoprecipitation Nature communications Medium 26932439
2016 PORCN knockdown in hippocampal neurons depletes TARP γ-8 from AMPAR complexes and accelerates AMPAR desensitization, an effect linked to the reduction of CNIH-2/3 within the complex. CNIH-2/3 co-purify as part of the AMPAR complex that is regulated by PORCN. PORCN knockdown in rat hippocampal neurons, co-immunoprecipitation of AMPAR complexes, electrophysiology Cell reports Medium 26776514
2018 SAP102-mediated rescue of AMPAR-evoked EPSCs requires the AMPAR auxiliary subunit CNIH-2, whereas CNIH-2 knockdown does not affect PSD-95-mediated AMPAR regulation, indicating that SAP102 and PSD-95 regulate AMPAR function through distinct auxiliary subunit pathways with CNIH-2 specifically mediating SAP102's effect. Cell-restricted molecular replacement (SAP102 expression with PSD-95 knockdown), CNIH-2 knockdown, whole-cell patch clamp recordings of EPSCs Journal of neurophysiology Medium 30067114
2023 CNIH-2 enhances tetramerization of wild-type and mutant AMPARs, primarily through interactions with the transmembrane domain of the receptor, increasing stability of the tetrameric complex. CNIH-2 enhances both GluA1 and GluA2 tetramerization, whereas CNIH-3 only weakly enhances GluA1 tetramerization. CNIH-2 enhances surface expression of functional AMPARs to a greater extent than TARP γ-2. Blue native PAGE tetramerization assays, surface biotinylation, mutagenesis of transmembrane domains, heterologous expression The Journal of biological chemistry Medium 37673338
2013 CNIH-2 and CNIH-3 show maximum mRNA and protein expression early after birth, declining toward adulthood, with an excess of AMPAR-free CNIH-2/3 early in development. During development, the proportion of CNIH-2/3 integrated into AMPAR complexes increases while AMPAR-free CNIH-2/3 subsides, reflecting a developmental transition from ancestral cargo exporter role to AMPAR auxiliary subunit role. Western blotting, qRT-PCR, co-immunoprecipitation at multiple postnatal timepoints in rat brain Molecular and cellular neurosciences Medium 23403072
2022 GluA1/2 receptors co-purify TARP-γ8, SynDIG4, and CNIH-2 with highest abundances, while GluA2/3 receptors show strongest co-purification of CNIH-2, TARP-γ2, and Noelin1. CNIH-2 associates preferentially with both major hippocampal AMPAR subtypes but shows subtype-specific differences in partner proteins. Interaction proteomics/co-immunoprecipitation from hippocampi of wildtype and Gria1- or Gria3-knockout mice, mass spectrometry Cells Medium 36429079
2024 CPSF3 promotes use of the proximal poly(A) site in the 3'UTR of CNIH2 mRNA; CPSF3 knockdown favors use of the distal poly(A) site producing a long-3'UTR CNIH2 isoform that is targeted by miR-125a-5p, resulting in reduced CNIH2 protein. CPSF3-induced ESCC tumorigenicity is mediated by CNIH2, establishing CNIH2 protein level as downstream of CPSF3-regulated alternative polyadenylation in esophageal squamous cell carcinoma. Iso-Seq and RNA-seq, CPSF3 knockdown/overexpression, luciferase reporter assays, in vitro proliferation/migration assays, in vivo tumor growth in nude mice Cancer letters Medium 38718887
2025 CNIH-2 mRNA is abundant in dendrites and CNIH-2 protein is locally synthesized. CNIH-2 local synthesis increases after chemical LTP induction. Local translation of CNIH-2 is required for plasma membrane insertion of GluA2-containing (calcium-impermeable) AMPARs but not GluA1-homomeric AMPARs, selectively enabling the trafficking of GluA2-containing receptors during LTP. FISH for dendritic mRNA localization, puromycin-based local translation assay, chemical LTP induction with GluA subtype-specific surface insertion measurement bioRxivpreprint Medium bio_10.1101_2025.02.08.637220
2026 Human CNIH2 expressed in S. cerevisiae in place of yeast Erv14 functionally complements phenotypes related to Erv14's role in monovalent-cation homeostasis and supports plasma-membrane targeting of the Na+/H+ antiporter NHA2, identifying NHA2 as a novel cargo of CNIH2 COPII cargo receptor activity. Yeast complementation assay, plasma-membrane targeting assays, AlphaFold3 modeling of CNIH-Sec24 interactions Protein science Low 41676957

Source papers

Stage 0 corpus · 38 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron 143 21172611
2015 Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. Annals of the rheumatic diseases 139 25646370
2013 Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron 127 23522044
2021 Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition. Nature 92 33981040
2012 Cornichons modify channel properties of recombinant and glial AMPA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 87 22815494
2016 GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons. Nature communications 74 26932439
2021 Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature 62 34079129
2011 Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology. The Journal of neuroscience : the official journal of the Society for Neuroscience 62 21543622
2014 Cornichon2 dictates the time course of excitatory transmission at individual hippocampal synapses. Neuron 45 24853943
2016 Porcupine Controls Hippocampal AMPAR Levels, Composition, and Synaptic Transmission. Cell reports 41 26776514
2018 A placental mammal-specific microRNA cluster acts as a natural brake for sociability in mice. EMBO reports 38 30552145
2012 AMPA receptors commandeer an ancient cargo exporter for use as an auxiliary subunit for signaling. PloS one 38 22292017
2014 Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice. Experimental neurology 32 25218043
2011 AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform. The European journal of neuroscience 31 22211840
2014 Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3. The Journal of neuroscience : the official journal of the Society for Neuroscience 29 25186755
2007 Cornichon-like protein facilitates secretion of HB-EGF and regulates proper development of cranial nerves. Molecular biology of the cell 22 17229890
2021 The Cardiac Glycoside Deslanoside Exerts Anticancer Activity in Prostate Cancer Cells by Modulating Multiple Signaling Pathways. Cancers 20 34830961
2012 Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia. Neuroreport 20 23103966
2022 Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition. Cells 18 36429079
2013 Auxiliary subunits provide new insights into regulation of AMPA receptor trafficking. Journal of biochemistry 17 23426437
2012 A 1 Mb de novo deletion within 11q13.1q13.2 in a boy with mild intellectual disability and minor dysmorphic features. European journal of medical genetics 17 22986108
2011 Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators. The Journal of biological chemistry 17 21343286
2013 Ontogeny repeats the phylogenetic recruitment of the cargo exporter cornichon into AMPA receptor signaling complexes. Molecular and cellular neurosciences 13 23403072
2015 TARP γ-8 glycosylation regulates the surface expression of AMPA receptors. The Biochemical journal 12 25495042
2015 Advances in the pharmacology of lGICs auxiliary subunits. Pharmacological research 11 26255765
2018 SAP102 regulates synaptic AMPAR function through a CNIH-2-dependent mechanism. Journal of neurophysiology 10 30067114
2015 Prolonged glutamate excitotoxicity increases GluR1 immunoreactivity but decreases mRNA of GluR1 and associated regulatory proteins in dissociated rat retinae in vitro. Biochimie 9 25792422
2023 A cornichon protein controls polar localization of the PINA auxin transporter in Physcomitrium patens. Development (Cambridge, England) 7 37052186
2021 Auxiliary Subunits Control Function and Subcellular Distribution of AMPA Receptor Complexes in NG2 Glia of the Developing Hippocampus. Frontiers in cellular neuroscience 7 34177466
2023 Differential regulation of tetramerization of the AMPA receptor glutamate-gated ion channel by auxiliary subunits. The Journal of biological chemistry 6 37673338
2024 CPSF3 regulates alternative polyadenylation of CNIH2 to promote esophageal squamous cell carcinoma progression. Cancer letters 5 38718887
2023 Imaging genetic association analysis of triple-negative breast cancer based on the integration of prior sample information. Frontiers in genetics 3 36911413
2025 Multifaceted disruption of AMPA receptor signaling by CACNG8 variants: Integrated evidence from human genetics and molecular simulation. Computational and structural biotechnology journal 2 41127817
2024 The Role of Cornichons in the Biogenesis and Functioning of Monovalent-Cation Transport Systems. Physiological research 2 38836370
2023 Differential regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) receptor tetramerization by auxiliary subunits. bioRxiv : the preprint server for biology 1 36798164
2026 Trafficking of the human Na+/H+ antiporter NHA2 to the plasma membrane requires cornichon COPII cargo receptors. Protein science : a publication of the Protein Society 0 41676957
2025 Modeling the use of transient ligand binding information by AMPA receptors. NPJ systems biology and applications 0 40595792
2024 Expression and role of CNIH2 in prostate cancer. Scientific reports 0 39433941

Missed literature

Know a paper Affinage missed for CNIH2? Flag it for the maintainers and the community.

No submissions yet.