Affinage

CNIH2

Protein cornichon homolog 2 · UniProt Q6PI25

Length
160 aa
Mass
18.9 kDa
Annotated
2026-04-28
55 papers in source corpus 20 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CNIH2 is a transmembrane auxiliary subunit of AMPA-type glutamate receptors that modulates receptor assembly, trafficking, gating kinetics, and synaptic transmission in hippocampal neurons. CNIH2 associates with AMPAR complexes in a TARP-γ8-dependent manner, occupying defined positions (A'/C') in the native receptor architecture where its extended M2 helix pivots toward the pore upon activation to slow deactivation and desensitization, enhance single-channel conductance and calcium permeability, and shape synapse-specific EPSC kinetics (PMID:21172611, PMID:34079129, PMID:24853943). Beyond gating modulation, CNIH2 promotes GluA subunit tetramerization through transmembrane domain interactions and facilitates ER-to-surface receptor trafficking via COPII-dependent export, functioning as both a cargo exporter and a bona fide auxiliary subunit (PMID:22292017, PMID:37673338). Conditional loss of CNIH2/3 selectively removes GluA1-containing AMPARs from hippocampal synapses, demonstrating a non-redundant role in determining the subunit composition and kinetic identity of synaptic receptor pools (PMID:23522044, PMID:22815494).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2007 Medium

    Before CNIH2 was linked to AMPA receptors, its ancestral role as a secretory pathway cargo exporter was established: CNIH2 facilitated HB-EGF secretion and its perturbation disrupted neural crest cell migration and cranial nerve patterning in chick embryos, revealing a developmental function through growth factor export.

    Evidence Cell culture secretion assay, dominant-negative and siRNA knockdown in chick embryos with phenotypic analysis

    PMID:17229890

    Open questions at the time
    • Chick ortholog study; relevance to mammalian CNIH2 function not directly tested
    • Mechanism of selective cargo recognition for HB-EGF not defined
    • Relationship to AMPAR biology unknown at this point
  2. 2010 High

    The discovery that CNIH2 physically associates with γ-8-containing AMPAR complexes in hippocampal postsynaptic densities established it as a neuronal AMPAR auxiliary subunit rather than merely an ER export factor; CNIH2 synergized with TARP-γ8 to modulate receptor kinetics and pharmacology, and its protein stability depended on γ-8.

    Evidence Reciprocal co-immunoprecipitation from PSDs, electrophysiology in recombinant systems and hippocampal neurons, γ-8 knockout mice

    PMID:21172611

    Open questions at the time
    • Structural basis of CNIH2–TARP–AMPAR interaction unknown
    • Whether CNIH2 reaches the neuronal surface independently of γ-8 was unclear
  3. 2011 High

    Systematic electrophysiological and pharmacological profiling revealed that CNIH2's gating modulation is TARP-isoform-dependent — slowing deactivation and occluding resensitization with γ-8 but having minimal kinetic effects with γ-2 — explaining region-specific AMPAR properties and showing that CNIH2 reduces TARP stoichiometry within receptor complexes.

    Evidence Electrophysiology with defined TARP isoforms in recombinant systems, tandem GluA/TARP stoichiometry-constrained constructs, surface biotinylation, radioligand binding with KO mice

    PMID:21343286 PMID:21543622 PMID:22211840

    Open questions at the time
    • Mechanism of stoichiometric competition between CNIH2 and TARPs at the molecular level unresolved
    • In vivo consequences of pharmacological modulation not tested
  4. 2012 High

    Two key properties of CNIH2 were mechanistically dissected: it cycles between ER and Golgi in a COPII-dependent manner (fulfilling an ancestral cargo export role that GluA subunits commandeer for surface delivery), and it enhances single-channel conductance, calcium permeability, and glutamate sensitivity of both CI- and CP-AMPARs.

    Evidence Live-cell imaging of ER-Golgi cycling, COPII export assays, single-channel recordings in heterologous cells

    PMID:22292017 PMID:22815494

    Open questions at the time
    • How GluA subunits redirect CNIH2 from ER cycling to surface retention not structurally defined
    • Whether COPII-dependent export is rate-limiting for synaptic AMPAR delivery in vivo unknown
  5. 2013 High

    Conditional knockout of CNIH2/3 in hippocampal neurons demonstrated a non-redundant requirement for surface expression and synaptic transmission of GluA1-containing AMPARs, with loss selectively removing GluA1A2 heteromers and leaving faster-kinetics GluA2A3 receptors — establishing CNIH2/3 as gatekeepers of AMPAR subunit composition at synapses.

    Evidence CNIH-2/CNIH-3 conditional knockout mice, whole-cell electrophysiology, surface receptor biochemistry, developmental co-IP

    PMID:23403072 PMID:23522044

    Open questions at the time
    • Whether CNIH2 and CNIH3 have distinct or fully redundant roles not fully separated
    • Downstream signaling consequences of altered subunit composition not explored
  6. 2014 High

    At identified hippocampal synapses, CNIH2 was shown to be the primary determinant of slow EPSC decay: knockdown accelerated mossy fiber–hilar mossy cell EPSCs, and ectopic expression in fast-EPSC interneurons slowed their kinetics, while structural work on CNIH3 identified the extracellular loop and membrane-proximal residues as critical for AMPAR binding and gating modulation.

    Evidence Paired whole-cell recordings with shRNA knockdown and viral gain-of-function; single-particle EM, peptide array screening, mutagenesis

    PMID:24853943 PMID:25186755

    Open questions at the time
    • Whether all hippocampal synapse types use CNIH2 to set kinetics not surveyed
    • Precise structural contacts between CNIH2 extracellular loop and AMPAR LBD not resolved at atomic level
  7. 2016 Medium

    The auxiliary subunit GSG1L was found to antagonize CNIH2-mediated slowing of AMPAR kinetics, revealing a competitive regulatory axis among auxiliary subunits, while PORCN was shown to regulate TARP-γ8 incorporation into AMPAR complexes including those containing CNIH2.

    Evidence Electrophysiology with GSG1L/CNIH2 co-expression; PORCN knockdown/KO with co-IP and electrophysiology

    PMID:26776514 PMID:26932439

    Open questions at the time
    • Whether GSG1L-CNIH2 competition occurs at the same binding site or allosterically is unknown
    • In vivo relevance of GSG1L–CNIH2 antagonism at specific synapses not demonstrated
  8. 2021 High

    Cryo-EM structures of native and reconstituted AMPAR complexes revealed the atomic-level architecture: CNIH2 and TARP-γ8 occupy non-equivalent positions (A'/C' and B'/D' respectively) with site-specific lipids, and upon receptor activation CNIH2's uniquely extended M2 helix counter-rotates and pivots toward the pore exit, providing the structural basis for its powerful gating modulation.

    Evidence Cryo-EM of native hippocampal AMPARs and reconstituted GluA1-GluA2/γ8/CNIH2 in resting and active states

    PMID:33981040 PMID:34079129

    Open questions at the time
    • Desensitized-state structure with CNIH2 not resolved
    • How lipid specificity at CNIH2 vs TARP sites affects function not tested
    • Structures of complexes with other auxiliary subunit combinations lacking
  9. 2023 Medium

    CNIH2 was found to promote AMPAR tetramerization through transmembrane domain interactions more effectively than TARP-γ2, revealing a previously unrecognized role in receptor assembly upstream of ER export.

    Evidence In vitro tetramerization assays, surface expression assays, mutagenesis in heterologous cells

    PMID:37673338

    Open questions at the time
    • Whether tetramerization enhancement is rate-limiting for AMPAR biogenesis in neurons not shown
    • Structural basis of TMD-mediated tetramerization promotion not determined
  10. 2024 Medium

    Outside the nervous system, CNIH2 was implicated in esophageal squamous cell carcinoma tumorigenicity, where CPSF3 promotes CNIH2 expression by inducing proximal poly(A) site usage that evades miR-125a-5p-mediated mRNA repression.

    Evidence APA analysis, CPSF3/CNIH2 knockdown and overexpression, xenograft tumor models, luciferase reporters

    PMID:38718887

    Open questions at the time
    • Whether CNIH2's tumorigenic role acts through AMPAR signaling or an AMPAR-independent mechanism is unknown
    • Single cancer type studied; generalizability not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: (1) the structural mechanism by which CNIH2 promotes tetramerization through TMD contacts, (2) how local dendritic translation of CNIH2 mRNA selectively enables GluA2-containing AMPAR insertion during LTP, (3) whether CNIH2 functions independently of AMPARs in non-neuronal contexts such as cancer, and (4) how the CNIH2–GSG1L competitive axis is regulated in vivo at specific synapse types.
  • No desensitized-state cryo-EM structure with CNIH2
  • Local translation findings from preprint not yet peer-reviewed
  • No CNIH2-specific knockout (separate from CNIH3) phenotype fully characterized in behavior

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 5 GO:0005198 structural molecule activity 4
Localization
GO:0005886 plasma membrane 4 GO:0005783 endoplasmic reticulum 2 GO:0005794 Golgi apparatus 1
Pathway
R-HSA-112316 Neuronal System 5 R-HSA-382551 Transport of small molecules 3 R-HSA-9609507 Protein localization 2
Partners
CACNG8CNIH3GRIA1GRIA2GRIA3GSG1LPORCNSAP102
Complex memberships
AMPAR-TARP-γ8-CNIH2 complexGluA1-GluA2/γ8/CNIH2 complexGluA2-GluA3/γ8/CNIH2 complex

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 CNIH-2 associates with γ-8-containing AMPA receptor complexes in hippocampal postsynaptic densities and abrogates γ-8-mediated resensitization, synergistically modulating AMPAR kinetics and pharmacology. CNIH-2 protein levels are markedly diminished in γ-8 knockout mice, indicating γ-8-dependent stabilization. Co-immunoprecipitation from postsynaptic densities, electrophysiology in recombinant systems and hippocampal neurons, γ-8 knockout mice Neuron High 21172611
2013 CNIH-2 and CNIH-3 are required for surface expression and synaptic transmission of GluA1-containing AMPARs (GluA1A2 heteromers) in hippocampal neurons; loss of CNIH-2/-3 selectively removes GluA1-containing receptors, leaving a residual pool of GluA2A3 heteromers with faster kinetics. TARP γ-8 prevents functional association of CNIHs with non-GluA1 subunits. CNIH-2/CNIH-3 conditional knockout mice, whole-cell electrophysiology, surface receptor biochemistry Neuron High 23522044
2021 Cryo-EM structure of native hippocampal AMPA receptor complexes shows that TARP-γ8 and CNIH2 occupy distinct auxiliary subunit positions (B'/D' and A'/C' respectively) beneath the ligand-binding domains of GluA1-GluA2 and GluA2-GluA3 receptors in a non-stochastic arrangement. Immunoaffinity purification of native hippocampal AMPARs, single-molecule fluorescence, cryo-electron microscopy Nature High 33981040
2021 Cryo-EM structures of GluA1-GluA2/TARP-γ8/CNIH2 in resting and active states reveal that two TARP-γ8 and two CNIH2 subunits insert at distinct sites beneath the LBDs, with site-specific lipids shaping each interaction. Upon activation, both auxiliary subunit pairs counter-rotate and pivot toward the pore exit; CNIH2 achieves this through its uniquely extended M2 helix, enabling powerful gating modulation. Cryo-electron microscopy, structural analysis of resting and active states Nature High 34079129
2012 CNIH-2 slows deactivation and desensitization of both GluA2-containing and calcium-permeable AMPARs, enhances glutamate sensitivity, single-channel conductance, and calcium permeability of CP-AMPARs, and decreases polyamine block. CNIH-2/3 but not CNIH-1 produce these effects. Electrophysiology in tsA201 cells, overexpression of CNIH-3 in oligodendrocyte precursor cells, single-channel recordings The Journal of neuroscience High 22815494
2011 CNIH-2 coexpression with GluA/TARP complexes reduces TARP stoichiometry within AMPA receptor complexes. In hippocampal neurons, CNIH-2 associates with surface AMPARs in a γ-8-dependent manner to dictate receptor pharmacology; in cerebellum, CNIH-2 does not reach the neuronal surface. Tandem GluA/TARP fusion constructs to constrain stoichiometry, surface biotinylation, pharmacological profiling, electrophysiology in neurons The Journal of neuroscience High 21543622
2012 CNIH-2 serves an evolutionarily conserved cargo exporter role, cycling between ER and Golgi in a COPII-dependent manner. GluA subunits recruit CNIH-2 to the cell surface, commandeering it from its ancestral ER-export role to function as a bona fide auxiliary subunit. Live-cell imaging of ER-Golgi cycling, COPII-dependent export assays, heterologous cell expression, primary rat neurons PloS one High 22292017
2014 CNIH2-containing AMPARs dictate the slow decay of EPSCs at hippocampal mossy fiber bouton–hilar mossy cell synapses. Selective knockdown of CNIH2 markedly accelerated EPSC decay without altering amplitude; viral expression of CNIH2 in aspiny interneurons (which normally lack it) slowed their fast EPSCs. Paired whole-cell recordings, selective knockdown via shRNA, virus-directed CNIH2 expression Neuron High 24853943
2014 CNIH-3 forms a stable complex with tetrameric AMPARs contributing to transmembrane density. Two clusters of conserved membrane-proximal residues mediate AMPAR binding; residues in the extracellular loop of CNIH-2/3 absent in CNIH-1/4 are critical for both AMPAR interaction and gating modulation. The AMPAR ligand-binding domain is the principal contact point for the CNIH-3 extracellular loop. Single-particle electron microscopy, peptide array screening, in vitro mutagenesis, binding and gating assays The Journal of neuroscience High 25186755
2011 CNIH-2 differentially modulates AMPAR gating depending on TARP isoform: with γ-8 (hippocampal), CNIH-2 slows deactivation, increases cyclothiazide potency and occludes resensitization; with γ-2 (cerebellar), CNIH-2 has minimal kinetic effects but decreases IKA/IGlu ratio. Electrophysiology in recombinant expression systems with defined TARP isoforms, pharmacological profiling The European journal of neuroscience High 22211840
2011 CNIH-2 allosterically modifies AMPA receptor pharmacology, conferring partial sensitivity of potentiator binding to displacement by non-competitive antagonists in a manner that depends on the auxiliary subunit composition of the receptor complex. Radioligand binding assays ([3H]-LY450295), autoradiography in brain sections from stargazer and γ-8 KO mice The Journal of biological chemistry Medium 21343286
2013 CNIH-2 and CNIH-3 associate with GluA subunits in the early secretory pathway; during ontogeny, an excess of AMPAR-free CNIH-2/3 exists early postnatally (consistent with ER cargo exporter role) but shifts toward AMPAR-integrated forms during development. Developmental expression profiling, co-immunoprecipitation, subcellular fractionation in rat brain Molecular and cellular neurosciences Medium 23403072
2016 GSG1L association with AMPARs inhibits CNIH2-induced slowing of receptor kinetics in heterologous cells, defining a competitive or antagonistic relationship between these two auxiliary subunits in modulating AMPAR deactivation and desensitization. Electrophysiology in heterologous cells with co-expression of GSG1L and CNIH2 Nature communications Medium 26932439
2018 SAP102-mediated rescue of AMPAR-mediated synaptic transmission requires CNIH-2; knockdown of CNIH-2 abolishes the SAP102-dependent increase in AMPAR EPSC decay time, placing CNIH-2 downstream of SAP102 in regulating synaptic AMPAR kinetics. Cell-restricted molecular replacement of PSD-95 with SAP102, CNIH-2 knockdown, whole-cell electrophysiology Journal of neurophysiology Medium 30067114
2007 CNIH2 (cornichon-like protein/CNIL) facilitates secretion of HB-EGF in a cell culture system, and its perturbation in chick embryos (by truncated CNIH expression or siRNA knockdown) disrupts neural crest cell distribution and cranial nerve development, phenocopying ErbB4 knockout. Cell culture secretion assay, chick embryo dominant-negative overexpression and siRNA knockdown, in situ hybridization Molecular biology of the cell Medium 17229890
2016 Knockdown of PORCN in hippocampal neurons leads to depletion of TARP γ-8 from AMPAR complexes, demonstrating that PORCN regulates the composition of AMPAR auxiliary subunit assemblies including CNIH-2/3-containing complexes. Immunoprecipitation of AMPAR complexes, PORCN knockdown and conditional KO, electrophysiology Cell reports Medium 26776514
2023 CNIH-2 enhances tetramerization of wild-type and mutant AMPARs, primarily through interactions with the transmembrane domain of the receptor, and promotes surface expression more effectively than TARP γ-2. CNIH-2 enhances both GluA1 and GluA2 tetramerization, whereas CNIH-3 only weakly enhances GluA1 tetramerization. In vitro tetramerization assays, surface expression assays in heterologous cells, mutagenesis The Journal of biological chemistry Medium 37673338
2022 Interaction proteomics demonstrates that CNIH-2 co-purifies with highest abundance in GluA1/2 receptor complexes alongside TARP-γ8 and SynDIG4, and also co-purifies strongly with GluA2/3 receptors, revealing subtype-specific AMPAR–auxiliary subunit associations. Interaction proteomics (immunoprecipitation–mass spectrometry) from Gria1 and Gria3 knockout mouse hippocampi Cells Medium 36429079
2024 CPSF3 promotes CNIH2 expression in esophageal squamous cell carcinoma by inducing use of a proximal poly(A) site in the CNIH2 3'UTR, thereby preventing miR-125a-5p-mediated repression of CNIH2 mRNA. CPSF3-induced tumorigenicity is mediated by CNIH2, as CNIH2 knockdown inhibits ESCC cell proliferation, migration, invasion, and tumor growth in vivo. Iso-Seq and RNA-seq APA analysis, CPSF3 knockdown/overexpression, colony formation/transwell assays, xenograft experiments, luciferase reporter for miRNA binding Cancer letters Medium 38718887
2025 CNIH-2 mRNA is locally translated in dendrites, and this local synthesis increases after chemical LTP induction. Local CNIH-2 translation is required for plasma membrane insertion of GluA2-containing (calcium-impermeable) AMPARs but not GluA1-homomeric AMPARs, selectively enabling slow-response AMPAR trafficking after plasticity induction. Dendritic mRNA localization assays, local translation reporters, chemical LTP induction, selective trafficking assays bioRxivpreprint Medium bio_10.1101_2025.02.08.637220

Source papers

Stage 0 corpus · 55 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2010 Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. Neuron 142 21172611
2015 Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. Annals of the rheumatic diseases 139 25646370
2013 Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron 126 23522044
2021 Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition. Nature 91 33981040
2012 Cornichons modify channel properties of recombinant and glial AMPA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 86 22815494
2016 GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons. Nature communications 73 26932439
2011 Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology. The Journal of neuroscience : the official journal of the Society for Neuroscience 62 21543622
2021 Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature 59 34079129
2015 Efficacy of ex vivo autologous and in vivo platelet transfusion in the reversal of P2Y12 inhibition by clopidogrel, prasugrel, and ticagrelor: the APTITUDE study. Circulation. Cardiovascular interventions 59 26553698
2021 3D-Image guided robotic-assisted partial nephrectomy: a multi-institutional propensity score-matched analysis (UroCCR study 51). World journal of urology 46 33811291
2014 Cornichon2 dictates the time course of excitatory transmission at individual hippocampal synapses. Neuron 45 24853943
2016 Porcupine Controls Hippocampal AMPAR Levels, Composition, and Synaptic Transmission. Cell reports 41 26776514
2012 AMPA receptors commandeer an ancient cargo exporter for use as an auxiliary subunit for signaling. PloS one 38 22292017
2018 A placental mammal-specific microRNA cluster acts as a natural brake for sociability in mice. EMBO reports 37 30552145
2014 Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice. Experimental neurology 32 25218043
2011 AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform. The European journal of neuroscience 31 22211840
2014 Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3. The Journal of neuroscience : the official journal of the Society for Neuroscience 29 25186755
2007 Cornichon-like protein facilitates secretion of HB-EGF and regulates proper development of cranial nerves. Molecular biology of the cell 22 17229890
2020 Added value of buccal cell FISH analysis in the diagnosis and management of Turner syndrome. Human reproduction (Oxford, England) 21 32810206
2021 The Cardiac Glycoside Deslanoside Exerts Anticancer Activity in Prostate Cancer Cells by Modulating Multiple Signaling Pathways. Cancers 20 34830961
2012 Upregulation of cornichon transcripts in the dorsolateral prefrontal cortex in schizophrenia. Neuroreport 20 23103966
2013 Auxiliary subunits provide new insights into regulation of AMPA receptor trafficking. Journal of biochemistry 17 23426437
2012 A 1 Mb de novo deletion within 11q13.1q13.2 in a boy with mild intellectual disability and minor dysmorphic features. European journal of medical genetics 17 22986108
2011 Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators. The Journal of biological chemistry 17 21343286
2022 Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition. Cells 16 36429079
2017 Screening of Wilson's disease in a psychiatric population: difficulties and pitfalls. A preliminary study. Annals of general psychiatry 16 28392828
2013 Ontogeny repeats the phylogenetic recruitment of the cargo exporter cornichon into AMPA receptor signaling complexes. Molecular and cellular neurosciences 13 23403072
1999 The mouse cornichon gene family. Development genes and evolution 12 10022955
2015 TARP γ-8 glycosylation regulates the surface expression of AMPA receptors. The Biochemical journal 11 25495042
2015 Advances in the pharmacology of lGICs auxiliary subunits. Pharmacological research 11 26255765
2020 Dental and craniofacial features associated with GNAS loss of function mutations. European journal of orthodontics 10 31696922
2018 SAP102 regulates synaptic AMPAR function through a CNIH-2-dependent mechanism. Journal of neurophysiology 10 30067114
2022 Genome Sequencing for Genetics Diagnosis of Patients With Intellectual Disability: The DEFIDIAG Study. Frontiers in genetics 9 35178068
2021 Predictive factors of recurrence after surgery in patients with non-metastatic renal cell carcinoma with venous tumor thrombus (UroCCR-56 Study). World journal of urology 9 33765164
2015 Prolonged glutamate excitotoxicity increases GluR1 immunoreactivity but decreases mRNA of GluR1 and associated regulatory proteins in dissociated rat retinae in vitro. Biochimie 9 25792422
2020 Impact of introducing a standardized nutrition protocol on very premature infants' growth and morbidity. PloS one 8 32437423
2023 A cornichon protein controls polar localization of the PINA auxin transporter in Physcomitrium patens. Development (Cambridge, England) 7 37052186
2020 Immediate preoperative renal artery embolization in the resection of complex renal tumors (UroCCR-48 Reinbol study). International urology and nephrology 7 32880091
2023 Differential regulation of tetramerization of the AMPA receptor glutamate-gated ion channel by auxiliary subunits. The Journal of biological chemistry 6 37673338
2021 Auxiliary Subunits Control Function and Subcellular Distribution of AMPA Receptor Complexes in NG2 Glia of the Developing Hippocampus. Frontiers in cellular neuroscience 6 34177466
2024 Pancreatic enzyme replacement therapy in subjects with exocrine pancreatic insufficiency and diabetes mellitus: a real-life, case-control study. Diabetology & metabolic syndrome 5 38331895
2024 CPSF3 regulates alternative polyadenylation of CNIH2 to promote esophageal squamous cell carcinoma progression. Cancer letters 5 38718887
2024 Outcomes and costs with the introduction of robotic-assisted thoracic surgery in public hospitals. Journal of robotic surgery 3 38492119
2023 Imaging genetic association analysis of triple-negative breast cancer based on the integration of prior sample information. Frontiers in genetics 3 36911413
2024 The Role of Cornichons in the Biogenesis and Functioning of Monovalent-Cation Transport Systems. Physiological research 2 38836370
2026 Predicting cardiovascular events in allogeneic haematopoietic stem cell transplant recipients. European journal of preventive cardiology 1 41026898
2025 Multifaceted disruption of AMPA receptor signaling by CACNG8 variants: Integrated evidence from human genetics and molecular simulation. Computational and structural biotechnology journal 1 41127817
2023 Differential regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) receptor tetramerization by auxiliary subunits. bioRxiv : the preprint server for biology 1 36798164
2022 The Economic, Medical and Psychosocial Consequences of Whole Genome Sequencing for the Genetic Diagnosis of Patients With Intellectual Disability: The DEFIDIAG Study Protocol. Frontiers in genetics 1 35444683
2019 Inyección Intraarticular Única de Ácido Hialurónico en la Artrosis de Rodilla: Estudio Multicéntrico Prospectivo Abierto (ART-ONE 75) mediante Comparación Post-Hoc con Placebo. Current therapeutic research, clinical and experimental 1 31193495
2026 Doravirine versus dolutegravir-based regimen in antiretroviral treatment-naive people living with HIV-1 (ANRS0392s ELDORADO): protocol for an international, open-label, randomised, non-inferiority, phase III trial. BMJ open 0 41644158
2026 Trafficking of the human Na+/H+ antiporter NHA2 to the plasma membrane requires cornichon COPII cargo receptors. Protein science : a publication of the Protein Society 0 41676957
2025 Are psychological attitudes towards vaccination an expression of personality? A cross-sectional study on COVID-19 vaccination in France. BMC public health 0 39825254
2025 Modeling the use of transient ligand binding information by AMPA receptors. NPJ systems biology and applications 0 40595792
2024 Expression and role of CNIH2 in prostate cancer. Scientific reports 0 39433941