Affinage

CEP97

Centrosomal protein of 97 kDa · UniProt Q8IW35

Length
865 aa
Mass
97.0 kDa
Annotated
2026-06-09
34 papers in source corpus 26 papers cited in narrative 26 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CEP97 is a conserved centriolar distal-tip protein that, together with CP110, forms a cap complex at the distal end of centrioles which suppresses ciliogenesis in cycling cells; CEP97 directly recruits CP110 to centrosomes, and loss of either protein triggers ectopic primary cilia formation while enforced CP110 suppresses cilia assembly in quiescent cells (PMID:17719545). The CEP97-CP110 cap nucleates a broader distal-tip interaction network including the kinesin-13 motor KIF24, which is required to retain CP110 at the mother centriole, and CEP104, which bridges CP110, CEP97, EB protein and tubulin at the centriole tip (PMID:21620453, PMID:22885064, PMID:27402853). Productive ciliogenesis requires the regulated removal of this cap from the mother centriole, a step controlled by an extensive upstream network: MPP9 forms a ring that recruits the complex by directly binding CEP97 and is degraded upon TTBK2 phosphorylation, ENKD1 competes with CEP97 for CP110 binding to drive CP110 release, and PCM1/centriolar satellites and LUBAC-mediated linear ubiquitination further facilitate cap disassembly (PMID:30375385, PMID:25297623, PMID:35301795, PMID:36790165, PMID:34813648). CEP97 is itself a phosphorylation substrate: TTBK2 and Dyrk1a phosphorylate CEP97, with Dyrk1a-dependent phosphorylation promoting Plk1 recruitment to drive centriole disengagement during multiciliogenesis (PMID:25297623, PMID:34787650). Beyond ciliary control, the CEP97-CP110 cap restricts centriole elongation by limiting Centrobin activity in cooperation with CDK1, and CEP97 loss in mice causes centriole overelongation, impaired ciliogenesis, attenuated Hedgehog signaling and disrupted heart development (PMID:42140673). In Drosophila, Cep97 forms a distal-tip ring and acts as the central scaffold recruiting the distal tip complex, maintaining centriole structural integrity in cooperation with the microtubule acetylation machinery (Sirt2/Atat1) (PMID:32589908, PMID:37729913, PMID:41347334). CEP97 levels also gate cell-type-specific cilia outcomes, capping docked mother centrioles to permanently prevent cilia regrowth in maturing neurons (PMID:39705308).

Mechanistic history

Synthesis pass · year-by-year structured walk · 23 steps
  1. 2007 High

    Established CEP97 as the physical recruiter of CP110 to centrosomes and defined the CEP97-CP110 complex as a collaborative inhibitor of ciliogenesis, answering what molecular activity restrains cilia assembly in cycling cells.

    Evidence Co-IP/MS complex purification, siRNA depletion with spindle/ploidy and ciliogenesis readouts, dominant-negative expression

    PMID:17719545

    Open questions at the time
    • Did not define how the complex is removed to permit ciliogenesis
    • No structural basis for CEP97-CP110 binding
  2. 2011 High

    Showed that the kinesin-13 KIF24 partners with CEP97-CP110 and is required to maintain CP110 at mother centrioles, linking the cap to centriolar microtubule remodeling.

    Evidence Co-IP, siRNA depletion, in vitro microtubule depolymerization assay

    PMID:21620453

    Open questions at the time
    • Did not define how KIF24 microtubule activity is regulated
    • Role of CEP97 in KIF24 recruitment versus retention not separated
  3. 2012 Medium

    Added CEP104 to the CEP97-CP110 distal-tip network and tied it functionally to ciliogenesis.

    Evidence Co-IP, siRNA depletion, immunofluorescence

    PMID:22885064

    Open questions at the time
    • Direct versus indirect CEP97-CEP104 binding not resolved at this stage
    • Single lab
  4. 2014 Medium

    Identified TTBK2 as a kinase that phosphorylates CEP97 and is required for CP110/CEP97 removal, providing a kinase trigger for cap disassembly at ciliogenesis onset.

    Evidence In vitro kinase assay, TTBK2 rescue/variant expression, siRNA depletion

    PMID:25297623

    Open questions at the time
    • Phosphosites on CEP97 and their functional consequence not mapped
    • In vitro phosphorylation not confirmed at endogenous sites in vivo
  5. 2015 Medium

    Placed proximal-end factors WDR8/Cep135 upstream of CP110-CEP97 removal, showing that distal cap disassembly is gated by proximal centriolar signals.

    Evidence siRNA depletion, epistasis analysis, immunofluorescence

    PMID:26675238

    Open questions at the time
    • Molecular link between proximal proteins and distal cap removal undefined
    • Single lab
  6. 2015 Medium

    Demonstrated that retention of CEP97-CP110 permits centrosome docking at the immunological synapse without ciliogenesis, dissociating docking from cilia formation.

    Evidence TEM tomography, immunofluorescence, siRNA depletion in CTLs

    PMID:26670998

    Open questions at the time
    • Mechanism keeping the cap retained in CTLs not defined
    • Single lab
  7. 2016 High

    Provided structural and biophysical mapping of the distal-tip network, demonstrating CEP104 binds CEP97, CP110, EB protein and tubulin directly.

    Evidence X-ray crystallography of CEP104 TOG domain, ITC/SPR binding assays

    PMID:27402853

    Open questions at the time
    • No structure of CEP97 itself
    • CEP97 binding interface not crystallized
  8. 2016 Medium

    Showed in Drosophila that Asterless/Cep152 controls centriole length via Cep97, implicating CEP97 in centriole elongation control.

    Evidence Drosophila genetic loss-of-function, immunofluorescence, centriole length phenotyping

    PMID:27185836

    Open questions at the time
    • Mechanism by which Cep97 limits length not defined here
    • Conservation to vertebrate length control untested
  9. 2018 High

    Defined MPP9 as a direct CEP97 binder forming a recruiting ring, whose TTBK2-triggered proteasomal degradation enables cap removal, linking the kinase trigger to a degradation step.

    Evidence Co-IP, super-resolution microscopy, proteasome inhibition, mouse kidney analysis

    PMID:30375385

    Open questions at the time
    • E3 ligase for MPP9 not identified
    • Whether CEP97 is itself degraded versus released unresolved
  10. 2018 Medium

    Ordered LRRC45 downstream of CP110-CEP97 removal by showing its depletion does not block cap removal, refining pathway architecture.

    Evidence siRNA depletion, immunofluorescence, epistasis

    PMID:30131441

    Open questions at the time
    • Negative result does not place LRRC45's exact step
    • Single lab
  11. 2020 High

    Established a structural-integrity role for Drosophila Cep97 as a protective cap cooperating with the microtubule acetylation machinery, distinguishing the fly cap (only transiently removed) from vertebrates.

    Evidence Drosophila genetic loss-of-function in multiple tissues, interaction screen identifying Sirt2, ultrastructural analysis

    PMID:32589908

    Open questions at the time
    • Whether vertebrate CEP97 has an analogous acetylation-linked role untested
    • Direct CEP97-Sirt2 binding interface not mapped
  12. 2021 High

    Showed that Dyrk1a phosphorylates CEP97 to recruit Plk1 and drive centriole disengagement during multiciliogenesis, connecting CEP97 phosphorylation to centriole separation machinery.

    Evidence Co-IP, in vitro kinase assay, morpholino knockdown and Separase rescue in Xenopus

    PMID:34787650

    Open questions at the time
    • CEP97 phosphosites recognized by Plk1 docking not mapped
    • Relationship between Dyrk1a and TTBK2 phosphorylation of CEP97 unresolved
  13. 2021 Medium

    Implicated LUBAC-mediated linear ubiquitination and the PRPF8 ubiquitin receptor in removal of the CP110-CEP97 cap, adding a ubiquitin-based disassembly route.

    Evidence Co-IP, ubiquitination assays, siRNA depletion, immunofluorescence

    PMID:34813648

    Open questions at the time
    • Direct ubiquitination of CEP97 itself not demonstrated
    • How linear ubiquitin drives physical removal unresolved
  14. 2022 Medium

    Revealed crosstalk in Drosophila embryos between the distal CP110-Cep97 cap and proximal Plk4-driven cartwheel growth, showing cap levels feed back on centriole biogenesis.

    Evidence Live imaging, genetic perturbation, quantitative fluorescence in Drosophila embryos

    PMID:35707992

    Open questions at the time
    • Molecular mediator of distal-to-proximal crosstalk unknown
    • Single lab
  15. 2022 High

    Identified ENKD1 as a competitor with CEP97 for CP110 binding that promotes CP110 release, defining a competition mechanism for cap disassembly.

    Evidence Co-IP, competitive binding assay, double-knockdown epistasis, super-resolution microscopy, mouse knockout

    PMID:35301795

    Open questions at the time
    • How ENKD1 access to CP110 is timed during ciliogenesis unclear
    • Effect on CEP97 retention versus CP110 retention not fully separated
  16. 2022 Medium

    Extended CEP97-CP110 function beyond cilia by showing the CP110-CEP97-CEP290 complex seeds aggresome assembly via a phospho-HSP27 ring at the centrosome.

    Evidence Quantitative microscopy, siRNA depletion, aggregation assays

    PMID:35411088

    Open questions at the time
    • Direct role of CEP97 versus CP110/CEP290 in seeding not dissected
    • Single lab
  17. 2022 Medium

    Mapped a Cep97 homolog to somatic tissues in C. elegans by interactome profiling, explaining its prior absence from worm studies.

    Evidence TurboID proximity labeling, mass spectrometry in whole animal

    PMID:35442950

    Open questions at the time
    • No direct functional assay for worm Cep97
    • Tissue-specific function untested
  18. 2023 Medium

    Showed PCM1/centriolar satellites facilitate efficient CP110-CEP97 removal and mother-centriole docking to the ciliary vesicle.

    Evidence Mouse and human RPE1 knockouts, ciliogenesis assays, immunofluorescence

    PMID:36790165

    Open questions at the time
    • Whether satellites act on the cap directly or via cargo delivery unresolved
    • Single lab
  19. 2023 High

    Established Drosophila Cep97 as the central scaffolding subunit recruiting the distal tip complex, and defined a Cep97-Cep104 role in spermiogenesis.

    Evidence Proximity-labeling interactome, Cep104-null fly genetics, immunofluorescence

    PMID:37729913

    Open questions at the time
    • Whether vertebrate CEP97 is the equivalent DTC scaffold untested
    • DTC assembly order not fully defined
  20. 2023 Medium

    Demonstrated a regulatory input where miR-106b in morphine-stimulated EVs targets CEP97 to lower its levels and de-repress ciliogenesis in astrocytes.

    Evidence miRNA target validation, anti-miR rescue, in vivo mouse morphine model, immunofluorescence

    PMID:37012704

    Open questions at the time
    • Other CEP97 mRNA regulators not surveyed
    • Single lab
  21. 2024 Medium

    Showed CEP97 is recruited to docked mother centrioles in maturing cerebellar neurons to cap them and permanently prevent cilia regrowth, defining a developmental cilia-loss mechanism.

    Evidence Single-cell transcriptomics, immunocytology, localization across differentiation

    PMID:39705308

    Open questions at the time
    • Trigger for CEP97 recruitment in maturing neurons unknown
    • Correlative localization, no perturbation of CEP97 in neurons
  22. 2026 High

    Established that CEP97-CP110 restricts centriole elongation by limiting Centrobin in cooperation with CDK1, and that CEP97 loss in mice causes overelongation, ciliogenesis defects, attenuated Hedgehog signaling and heart defects, linking CEP97 to development.

    Evidence Centrosome-specific phosphoproteomics, CDK1 inhibition, CEP97 knockout mice, HH and ciliogenesis readouts

    PMID:42140673

    Open questions at the time
    • Direct CEP97-Centrobin interaction not detailed
    • Mechanism distinguishing CEP97-CP110 from CDK1 inhibition of Centrobin not fully resolved
  23. 2026 Medium

    Resolved Cep97 as a ring structure at the distal tip in Drosophila by expansion microscopy, clarifying its geometry as a cap on the growing centriole end.

    Evidence Expansion microscopy of S2 cells and fly tissues

    PMID:41347334

    Open questions at the time
    • Ring geometry not confirmed for vertebrate CEP97
    • Molecular organization within the ring not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CEP97 itself is physically displaced and turned over during cap removal — versus its partner CP110 — and the molecular interface CEP97 uses to bind CP110 remain unresolved.
  • No high-resolution structure of CEP97 or its CP110-binding interface
  • Whether CEP97 is degraded, released, or sequestered during cap removal not established
  • Functional phosphosites on CEP97 not mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 3
Localization
GO:0005815 microtubule organizing center 4 GO:0005856 cytoskeleton 2
Pathway
R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-1266738 Developmental Biology 2 R-HSA-162582 Signal Transduction 1
Partners
CEP104CP110DYRK1AENKD1KIF24MPP9SIRT2TTBK2
Complex memberships
CP110-CEP97 distal-tip cap complexCP110-CEP97-CEP290 complexcentriole distal tip complex (DTC)

Evidence

Reading pass · 26 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 CEP97 was purified as part of a complex with CP110 and directly recruits CP110 to centrosomes; depletion of CEP97 causes CP110 disappearance from centrosomes, spindle defects, and polyploidy. Loss of CEP97 or CP110 promotes primary cilia formation in cycling cells, and enforced CP110 expression suppresses cilia assembly in quiescent cells, establishing CEP97 and CP110 as collaborative inhibitors of ciliogenesis. Biochemical complex purification (Co-IP/MS), siRNA depletion, dominant-negative mutant expression, immunofluorescence Cell High 17719545
2011 Kif24, a kinesin-13 subfamily motor protein, specifically interacts with CP110 and CEP97 at centrosomes, preferentially localizes to mother centrioles, and is required for maintaining CP110 at mother centrioles in cycling cells. Kif24 can bind and depolymerize microtubules in vitro, and its ectopic expression specifically remodels centriolar microtubules. Co-immunoprecipitation, siRNA depletion, in vitro microtubule depolymerization assay, immunofluorescence Cell High 21620453
2012 CEP104 interacts with CP110 and CEP97 at the centriole and is required for ciliogenesis, placing CEP104 in the CP110-CEP97 regulatory network at centrioles. Co-immunoprecipitation, siRNA depletion, immunofluorescence Current biology : CB Medium 22885064
2013 MARK4 knockdown arrests the ciliogenesis program before complete removal of the CP110-CEP97 inhibitory complex from the mother centriole, placing MARK4 and ODF2 upstream of CP110-CEP97 removal in the ciliogenesis pathway. siRNA depletion, immunofluorescence, epistasis analysis The Journal of cell biology Medium 23400999
2014 TTBK2 kinase has the potential to phosphorylate CEP97 in vitro, and TTBK2 recruitment to the mother centriole (via Cep164 binding) is required for CP110 and CEP97 removal during ciliogenesis initiation. In vitro kinase assay, TTBK2 variant expression/rescue, siRNA depletion, immunofluorescence Genes to cells : devoted to molecular & cellular mechanisms Medium 25297623
2015 WDR8 and Cep135, proximal-end centriolar proteins, are required for unlocking the distal end of the mother centriole from the CP110-CEP97 inhibitory complex, placing them upstream of CP110-CEP97 removal in ciliogenesis. siRNA depletion, immunofluorescence, epistasis analysis Journal of cell science Medium 26675238
2015 In cytotoxic T lymphocytes (CTLs), CP110 and CEP97 remain associated with the mother centriole during centrosome docking at the immunological synapse, and no axoneme or transition zone ciliary structures form, establishing that centrosome docking can occur without ciliogenesis when CP110-CEP97 is retained. High-resolution TEM tomography, immunofluorescence, siRNA depletion Current biology : CB Medium 26670998
2016 Crystal structure of CEP104's TOG domain was solved, and biophysical characterization demonstrated direct interactions between CEP104 and CP110, CEP97, EB protein, and tubulin, mapping the interaction network at the centriole distal tip. X-ray crystallography, biophysical binding assays (ITC/SPR), sequence analysis The Journal of biological chemistry High 27402853
2016 In Drosophila, Asterless (Asl, ortholog of Cep152) controls centriole length via the centriole protein Cep97; loss of Asl affects Cep97-dependent centriole length regulation in germline and somatic tissue. Genetic loss-of-function (Drosophila), immunofluorescence, phenotypic analysis of centriole length The Journal of cell biology Medium 27185836
2018 MPP9 is recruited by KIF24 to the distal end of the mother centriole where it forms a ring-like structure and recruits the CP110-CEP97 complex by directly binding CEP97. Upon phosphorylation by TTBK2 at the onset of ciliogenesis, MPP9 is degraded via the ubiquitin-proteasome system, facilitating removal of CP110 and CEP97 from the mother centriole. Co-immunoprecipitation, super-resolution microscopy, siRNA depletion, ubiquitin-proteasome inhibitor treatment, mouse kidney analysis Nature communications High 30375385
2018 LRRC45 depletion does not impair removal of CP110-CEP97 from the mother centriole, establishing LRRC45 acts downstream of CP110-CEP97 removal in ciliogenesis. siRNA depletion, immunofluorescence, epistasis analysis Journal of cell science Medium 30131441
2020 In Drosophila, Cep97 is essential for formation of full-length centrioles in multiple tissues and interacts with the microtubule deacetylase Sirt2; both Sirt2 deletion and Atat1 (acetylase) deletion affect centriole size, supporting a model whereby Cep97 acts as a protective cap cooperating with the microtubule acetylation machinery to maintain centriole stability. Unlike in vertebrates, Drosophila Cep97 is only transiently removed from basal bodies and its loss strongly impairs ciliogenesis. Genetic loss-of-function (Drosophila), Co-immunoprecipitation/interaction screen, immunofluorescence, ultrastructural analysis Current biology : CB High 32589908
2021 CEP97 interacts with Dyrk1a kinase in Xenopus multiciliated cells; Dyrk1a phosphorylates CEP97, which promotes recruitment of Plk1, a critical regulator of centriole disengagement that cooperates with Separase for centriole separation during multiciliogenesis. Knockdown of either CEP97 or Dyrk1a disrupts cilia formation and centriole disengagement, rescued by Separase overexpression. Co-immunoprecipitation, in vitro kinase assay, morpholino knockdown in Xenopus, rescue experiments with Separase overexpression, immunofluorescence The Journal of cell biology High 34787650
2021 LUBAC-mediated linear ubiquitination of CP110 is required for CP110 removal from the mother centriole, with PRPF8 acting as a receptor for linear ubiquitin chains at the distal mother centriole. CEP97, as part of the CP110-CEP97 complex, is targeted by this LUBAC-dependent mechanism. Co-immunoprecipitation, ubiquitination assays, siRNA depletion, immunofluorescence The Journal of cell biology Medium 34813648
2022 In Drosophila embryos, CP110 and CEP97 form a complex at the distal end of centrioles whose levels oscillate as centriole MTs grow; altering CP110 or Cep97 levels perturbs the Plk4 oscillation and cartwheel growth at the proximal end, revealing crosstalk between distal-end cap proteins and proximal-end centriole growth machinery. Live imaging, genetic manipulation (CP110/Cep97 overexpression/depletion), quantitative fluorescence microscopy in Drosophila embryos Journal of cell science Medium 35707992
2022 ENKD1 competes with CEP97 for binding to CP110; depletion of ENKD1 enhances the CP110-CEP97 interaction and detains CP110 at the mother centriole, blocking ciliogenesis. Simultaneous knockdown of ENKD1 and CP110 reverses the ciliogenesis defect, placing ENKD1 as a positive regulator of CP110 removal by competing with CEP97. Co-immunoprecipitation, competitive binding assay, siRNA depletion, double-knockdown epistasis, super-resolution microscopy, mouse knockout EMBO reports High 35301795
2022 The CP110-CEP97-CEP290 centrosomal complex is required for seeding the initial phosphorylated HSP27 ring during aggresome assembly at the centrosome; limiting amounts of CP110 in senescent cells impairs aggresome formation and aggregation of mutant huntingtin. High-resolution quantitative microscopy, siRNA depletion, immunofluorescence, functional aggregation assays Nature cell biology Medium 35411088
2022 In C. elegans, homologs of Cep97 and Cep135/BLD10 are expressed in somatic tissues but not in early embryos, identified by proximity-labeling TurboID interactome mapping; their tissue-specific expression explains why these conserved centriolar components had not been previously identified in worm. TurboID proximity labeling, mass spectrometry, GFP-nanobody indirect proximity labeling in whole animal PLoS genetics Medium 35442950
2023 PCM1 and centriolar satellites facilitate efficient removal of CP110 and CEP97 from the distal mother centriole during ciliogenesis initiation; Pcm1-null RPE1 cells show reduced docking of the mother centriole to the ciliary vesicle and impaired CP110 and CEP97 removal. Genetic knockout (mouse and human RPE1 cells), immunofluorescence, ciliogenesis assays eLife Medium 36790165
2023 In Drosophila, Cep97 is the central scaffolding unit required to recruit distal tip complex (DTC) components to the distal tip of centrioles; Cep104 and Cep97 cooperate during spermiogenesis to align spermatids and coordinate individualization. Proximity-labeling screen, genetic loss-of-function (Cep104 null flies), immunofluorescence, interactome mapping Current biology : CB High 37729913
2024 During cerebellar granule cell differentiation, CEP97 is recruited to docked mother centrioles in maturing neurons, capping them and preventing cilia regrowth, establishing a mechanism by which cilia are permanently lost in mature neurons. Single-cell transcriptomics, immunocytology, subcellular localization analysis across differentiation stages Proceedings of the National Academy of Sciences of the United States of America Medium 39705308
2023 miR-106b in morphine-stimulated astrocyte-derived extracellular vesicles targets CEP97, reducing CEP97 levels in recipient astrocytes to promote primary ciliogenesis; anti-miR-106b delivery restores CEP97 expression and inhibits ciliogenesis. miRNA targeting validation, anti-miR delivery, immunofluorescence, in vivo mouse morphine tolerance model Molecular therapy : the journal of the American Society of Gene Therapy Medium 37012704
2026 CDK1 phosphorylates centriolar proteins including Centrobin at the centrosome, and CEP97-CCP110 restricts Centrobin localization to centrioles; CDK1-dependent phosphorylation suppresses Centrobin's centriole elongation activity. CEP97-CCP110 and CDK1 cooperatively restrict centriole elongation by inhibiting Centrobin via distinct mechanisms. Removal of CEP97 during mouse development causes centriole overelongation, impaired ciliogenesis, attenuated Hedgehog signaling, and disrupted heart development. Centrosome-specific phosphoproteomics, CDK1 inhibition, CEP97 knockout mice, ciliogenesis assays, HH signaling readouts, immunofluorescence Genes & development High 42140673
2026 Expansion microscopy of Drosophila S2 cells reveals that Cep97 forms a ring structure at the distal tip of the centriole, clarifying its role as a cap on the growing centriole end. Expansion microscopy (ExM) of S2 cells and fly tissues Journal of cell science Medium 41347334
2025 CEP76 interacts with CCP110 and CEP97 (identified by proteomics), and CEP76 depletion impairs ciliogenesis; this places CEP76 in the CP110-CEP97 interaction network at the centrosome-cilium interface. Proximity proteomics, siRNA depletion, ciliary phenotype analysis in RPE1 cells Science advances Low 41105778
2025 EHD1, through its membrane tubulation function, directly promotes CP110/CEP97 removal from the mother centriole cap during ciliogenesis progression, linking membrane tubule formation at the mother centriole to distal cap disassembly. 3D isotropic EM ultrastructure imaging, siRNA depletion of EHD1, quantitative analysis of CP110/CEP97 removal bioRxiv (preprint)preprint Medium 40894589

Source papers

Stage 0 corpus · 34 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 Cep97 and CP110 suppress a cilia assembly program. Cell 388 17719545
2012 A Proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins. Current biology : CB 175 22885064
2011 Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis. Cell 165 21620453
2013 The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis. The Journal of cell biology 69 23400999
2018 M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole. Nature communications 68 30375385
2015 Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis. Current biology : CB 62 26670998
2014 Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis. Genes to cells : devoted to molecular & cellular mechanisms 55 25297623
2018 LRRC45 contributes to early steps of axoneme extension. Journal of cell science 42 30131441
2023 Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis. eLife 41 36790165
2015 TTBK2: a tau protein kinase beyond tau phosphorylation. BioMed research international 37 25950000
2022 Aggresome assembly at the centrosome is driven by CP110-CEP97-CEP290 and centriolar satellites. Nature cell biology 36 35411088
2018 Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome. American journal of human genetics 34 29395072
2022 Genome-wide association studies of COVID-19: Connecting the dots. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 32 36280088
2015 WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis. Journal of cell science 32 26675238
2016 Biophysical and Structural Characterization of the Centriolar Protein Cep104 Interaction Network. The Journal of biological chemistry 31 27402853
2016 Asterless is required for centriole length control and sperm development. The Journal of cell biology 29 27185836
2022 A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. PLoS genetics 27 35442950
2020 Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila. Current biology : CB 27 32589908
2022 ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis. EMBO reports 26 35301795
2021 LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole. The Journal of cell biology 21 34813648
2023 Extracellular vesicle-mediated delivery of anti-miR-106b inhibits morphine-induced primary ciliogenesis in the brain. Molecular therapy : the journal of the American Society of Gene Therapy 14 37012704
2020 KCTD10 Biology: An Adaptor for the Ubiquitin E3 Complex Meets Multiple Substrates: Emerging Divergent Roles of the cullin-3/KCTD10 E3 Ubiquitin Ligase Complex in Various Cell Lines. BioEssays : news and reviews in molecular, cellular and developmental biology 13 32484264
2014 The nuclear pool of tetraspanin CD9 contributes to mitotic processes in human breast carcinoma. Molecular cancer research : MCR 13 25103498
2024 Permanent cilia loss during cerebellar granule cell neurogenesis involves withdrawal of cilia maintenance and centriole capping. Proceedings of the National Academy of Sciences of the United States of America 11 39705308
2022 Centriole distal-end proteins CP110 and Cep97 influence centriole cartwheel growth at the proximal end. Journal of cell science 11 35707992
2021 CEP97 phosphorylation by Dyrk1a is critical for centriole separation during multiciliogenesis. The Journal of cell biology 9 34787650
2023 Cep104 is a component of the centriole distal tip complex that regulates centriole growth and contributes to Drosophila spermiogenesis. Current biology : CB 5 37729913
2026 Visualizing Drosophila centrioles by expansion microscopy. Journal of cell science 2 41347334
2025 Disrupted glucocorticoid receptor cell signalling causes a ciliogenesis defect in the fetal mouse renal tubule. EMBO reports 1 40247090
2025 CEP76 impairment at the centrosome-cilium interface contributes to a spectrum of ciliopathies. Science advances 1 41105778
2026 CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning. Genes & development 0 42140673
2025 Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis. Clinical epigenetics 0 39819503
2025 The interplay between Wnt and mTOR signaling modulates ciliogenesis in human retinal epithelial cells. PLoS biology 0 40892854
2025 Characterization of membrane structures regulating primary ciliogenesis by quantitative isotropic ultrastructure imaging. bioRxiv : the preprint server for biology 0 40894589

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