- Length
- 708 aa
- Mass
- 76.6 kDa
- Annotated
- 2026-04-28
130 papers in source corpus
10 papers cited in narrative
10 extracted findings
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
Insufficient on-target evidence to synthesize a narrative — discovery timeline does not match the canonical CAST protein.
Mechanism profile
Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.
Evidence
Reading pass · 10 per-paper findings extracted from the source corpus
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 2008 | Crystal structure of calcium-bound calpain 2 heterodimer bound by an inhibitory domain of calpastatin at 2.4-Å resolution revealed the mechanism of inhibition: calpastatin occupies both sides of the active site cleft, passes through the cleft but escapes cleavage by looping around the active site cysteine, and recognizes multiple lower-affinity sites present only in the calcium-bound form of calpain. The structure also revealed conformational changes calpain undergoes upon calcium binding, including opening of the active site cleft and domain compaction. | X-ray crystallography (2.4 Å resolution crystal structure of calpain 2–calpastatin inhibitory domain complex) | Nature | High | 19020623 |
| 1989 | Calpastatin was established as the endogenous intracellular inhibitor of calpains (calpain I/μ-calpain and calpain II/m-calpain). Structure–function analysis using mutated cDNAs expressed in E. coli defined the inhibitory domains of calpastatin. Interleukin-2 receptor-linked expression of calpastatin was demonstrated in HTLV-I-infected T-cells, and calpastatin was shown to inhibit calcium-dependent calpain proteolytic activity. | Biochemical inhibition assays, site-directed mutagenesis of cDNA expressed in E. coli, cell-based expression studies | Biochemistry international | High | 2548504 |
| 1998 | Calpastatin is cleaved by caspases during early apoptosis. In anti-Fas or staurosporine-treated Jurkat T-cells and apoptotic SH-SY5Y neuroblastoma cells, the high-molecular-weight form of calpastatin (110 kDa) was degraded to immunoreactive fragments (75 kDa, 30 kDa). In vitro, recombinant caspase-1, -3, and -7 all cleaved calpastatin; caspase-1 cleaved at ALDD137↓L, LSSD203↓F, and ALAD404↓S (in domains I and III), while caspase-3 cleaved only at ALDD137↓L. Cleavage was blocked by caspase-specific inhibitors. Notably, caspase-1-fragmented calpastatin retained near-normal calpain inhibitory activity, suggesting that caspase-mediated fragmentation has effects beyond loss of calpain inhibition. | In vitro cleavage assays with recombinant caspases, immunoblot of apoptotic cells, caspase inhibitor pretreatment, in vitro translation | Archives of biochemistry and biophysics | High | 9705209 |
| 1999 | Calpastatin overexpression partially blocked TNF-α-inducible IκBα proteolysis and NF-κB-dependent promoter activity in HepG2 cells, demonstrating that cytosolic m-calpain mediates a proteasome-independent pathway for IκBα degradation and NF-κB activation in parallel to the ubiquitin-proteasome pathway. | Transient cotransfection with calpastatin expression construct, fluorescent calpain activity assay, NF-κB reporter assay, cell fractionation, broken-cell reconstitution with purified m-calpain | The Journal of biological chemistry | High | 9873017 |
| 1999 | CAST (CD3ε-associated signal transducer, later identified as hPAF49/RNA Pol I subunit) was isolated as a novel CD3ε-binding protein. It specifically interacts in vivo and in vitro with CD3ε but not CD3ζ or FcRγ, via a unique membrane-proximal region of CD3ε. CAST contains a single tyrosine that undergoes tyrosine phosphorylation upon TCR stimulation. Dominant-negative CAST constructs (minimum CD3ε-binding domain or tyrosine mutant) strongly suppressed NFAT activation and IL-2 production, indicating CAST transduces activation signals through the CD3ε-containing TCR signaling module. | Co-immunoprecipitation (in vivo and in vitro), yeast two-hybrid, dominant-negative overexpression, NFAT-luciferase reporter assay, IL-2 ELISA | The Journal of biological chemistry | Medium | 10373416 |
| 2006 | The human RNA Polymerase I-specific subunit CAST (also called hPAF49, previously identified as CD3ε-associated CAST) was characterized as an integral component of initiation-competent Pol Iβ complexes. CAST/hPAF49 undergoes growth-regulated tyrosine phosphorylation at a conserved residue. It interacts with the activator UBF and weakly with SL1 at the rDNA promoter. CAST/hPAF49-specific antibodies and excess CAST/hPAF49 protein inhibit UBF-activated transcription but not basal Pol I transcription, and disrupt the CAST/hPAF49–UBF interaction, indicating that its interaction with UBF is required for transcriptional activation. | Immunoprecipitation, in vitro transcription assay, antibody inhibition, chromatin immunoprecipitation, phosphorylation analysis | Molecular and cellular biology | Medium | 16809778 |
| 2008 | In Alzheimer's disease neurons, calpastatin (CAST) is markedly depleted through proteolysis mediated by caspase-1, caspase-3, and calpains themselves, creating a feed-forward loop. CAST depletion along dendrites coincides topographically with calpain II and ERK1/2 activation, caspase-3-mediated tau cleavage, and tau/neurofilament hyperphosphorylation. In mice, intrahippocampal kainic acid administration reproduced these changes and caused cytoskeletal proteolysis and neuronal death; these effects were substantially reduced in mice overexpressing human CAST. shRNA-mediated CAST reduction in neuronal cells caused calpain-mediated death at calcium-injury levels sublethal to CAST-expressing cells. | Immunofluorescence/immunohistochemistry of AD brain, intrahippocampal kainic acid mouse model, transgenic CAST overexpression, shRNA knockdown in neuronal cells, cell death assays (propidium iodide, LDH) | The Journal of neuroscience | High | 19020018 |
| 2018 | Pin1 (peptidyl-prolyl cis/trans isomerase) interacts with calpastatin (CAST) and regulates CAST activity, thereby modulating CAST/calpain2-mediated necrosis in retinal neurons under glutamate excitotoxicity. Co-IP and computer simulation confirmed Pin1–CAST binding. Juglone (Pin1 inhibitor) reduced CAST phosphorylation and shifted CAST/calpain2 balance to decrease necrosis; siRNA knockdown of Pin1 in RGC-5 cells confirmed the regulatory pathway. In vivo, Pin1 inhibition protected retinal ganglion cells from glutamate-induced damage. | Co-immunoprecipitation, computer simulation (docking), western blot, real-time qPCR, siRNA knockdown, flow cytometry, propidium iodide staining, LDH assay, flash electroretinogram | Frontiers in cellular neuroscience | Medium | 29403356 |
| 2019 | A homozygous nonsense mutation in CAST (c.544G>T, p.Glu182*) causes PLACK syndrome (peeling skin, leukonychia, acral keratoses, cheilitis, knuckle pads). Real-time qRT-PCR and immunoblot analysis of skin fibroblasts from affected individuals showed reduced calpastatin expression, and in vitro calpastatin activity assays demonstrated decreased inhibitory activity, establishing loss of calpastatin function as the causative mechanism. | Whole exome sequencing, Sanger sequencing validation, real-time qRT-PCR, immunoblot, in vitro calpastatin activity assay | Cell and tissue research | High | 31392520 |
| 2013 | Genetic association analysis mapped a CAST gene SNP (rs4434401) to keratoconus susceptibility in both familial and case-control cohorts (combined meta P=0.002), with in silico analysis suggesting differential regulation of the calpain/calpastatin system in cornea as a potential functional mechanism underlying the association. | SNP genotyping, generalized estimating equation models in family cohort, logistic regression in case-control cohort, in silico expression analysis | Cornea | Low | 23449483 |
Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2006 | Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | Cell | 2861 | 17081983 |
| 2012 | Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. | Cell | 1718 | 22658674 |
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 2004 | Large-scale characterization of HeLa cell nuclear phosphoproteins. | Proceedings of the National Academy of Sciences of the United States of America | 1159 | 15302935 |
| 2015 | The BioPlex Network: A Systematic Exploration of the Human Interactome. | Cell | 1118 | 26186194 |
| 2017 | Architecture of the human interactome defines protein communities and disease networks. | Nature | 1085 | 28514442 |
| 2015 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. | Cell | 1015 | 26496610 |
| 2010 | A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. | Nature genetics | 843 | 20953190 |
| 2018 | VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. | Cell discovery | 829 | 29507755 |
| 2000 | DNA cloning using in vitro site-specific recombination. | Genome research | 815 | 11076863 |
| 2003 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | Nature genetics | 754 | 14702039 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2012 | A census of human soluble protein complexes. | Cell | 689 | 22939629 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Genome research | 438 | 15489334 |
| 2005 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | Genome research | 409 | 16344560 |
| 2015 | Panorama of ancient metazoan macromolecular complexes. | Nature | 407 | 26344197 |
| 1996 | Normalization and subtraction: two approaches to facilitate gene discovery. | Genome research | 401 | 8889548 |
| 2009 | Genome-wide association study of alcohol dependence. | Archives of general psychiatry | 301 | 19581569 |
| 2017 | Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. | Proceedings of the National Academy of Sciences of the United States of America | 282 | 28611215 |
| 2012 | A high-throughput approach for measuring temporal changes in the interactome. | Nature methods | 273 | 22863883 |
| 1989 | Intracellular regulatory system involving calpain and calpastatin. | Biochemistry international | 266 | 2548504 |
| 2008 | Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin. | Nature | 264 | 19020623 |
| 2000 | Integrin signalling: a new Cas(t) of characters enters the stage. | Trends in cell biology | 258 | 10675905 |
| 2002 | Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1. | The Journal of cell biology | 239 | 12163476 |
| 2017 | Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification. | Nature communications | 221 | 28524877 |
| 1998 | Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis. | Archives of biochemistry and biophysics | 217 | 9705209 |
| 1999 | Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation. | The Journal of biological chemistry | 213 | 9873017 |
| 2015 | ∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. | Nature | 209 | 26618866 |
| 2018 | An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. | Nature communications | 201 | 29568061 |
| 1996 | Directing alternative splicing: cast and scenarios. | Trends in genetics : TIG | 185 | 8973158 |
| 1995 | Pet ownership, social support, and one-year survival after acute myocardial infarction in the Cardiac Arrhythmia Suppression Trial (CAST). | The American journal of cardiology | 181 | 7502998 |
| 2009 | Receptor for AGE (RAGE) and its ligands-cast into leading roles in diabetes and the inflammatory response. | Journal of molecular medicine (Berlin, Germany) | 180 | 19189073 |
| 2021 | Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq. | Cell stem cell | 166 | 33626327 |
| 2019 | MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1. | Gastroenterology | 165 | 30711629 |
| 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. | American journal of human genetics | 164 | 19913121 |
| 1992 | Pathobiology of cast nephropathy from human Bence Jones proteins. | The Journal of clinical investigation | 159 | 1737851 |
| 2004 | Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release. | The Journal of cell biology | 158 | 14734538 |
| 2001 | Chromatin remodeling and transcriptional activation: the cast (in order of appearance). | Oncogene | 157 | 11420714 |
| 2006 | Fish cast NETs: neutrophil extracellular traps are released from fish neutrophils. | Developmental and comparative immunology | 136 | 17222907 |
| 2022 | Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast? | Nature reviews. Immunology | 106 | 35484322 |
| 2004 | Surface properties and biocompatibility of solvent-cast poly[-caprolactone] films. | Biomaterials | 94 | 15120520 |
| 2015 | Complex histories of repeated gene flow in Cameroon crater lake cichlids cast doubt on one of the clearest examples of sympatric speciation. | Evolution; international journal of organic evolution | 89 | 25929355 |
| 2008 | Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 88 | 19020018 |
| 2011 | Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones. | The Journal of neuroscience : the official journal of the Society for Neuroscience | 86 | 21228161 |
| 2004 | NF-kappaB signaling in lymphocytes: a new cast of characters. | Journal of cell science | 81 | 14657271 |
| 2021 | Excellent Specific Mechanical and Electrical Properties of Anisotropic Freeze-Cast Native and Carbonized Bacterial Cellulose-Alginate Foams. | Advanced functional materials | 80 | 37476032 |
| 2015 | Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. | Neuron | 79 | 26004914 |
| 1990 | New data on excisions of Mu from E. coli MCS2 cast doubt on directed mutation hypothesis. | Nature | 77 | 2407962 |
| 2011 | CAST AWAY, a membrane-associated receptor-like kinase, inhibits organ abscission in Arabidopsis. | Plant physiology | 73 | 21628627 |
| 2011 | Cancer stromal targeting (CAST) therapy. | Advanced drug delivery reviews | 72 | 22212902 |
| 2020 | Clinicopathologic predictors of renal outcomes in light chain cast nephropathy: a multicenter retrospective study. | Blood | 71 | 32160635 |
| 2017 | Bovine Polymorphonuclear Neutrophils Cast Neutrophil Extracellular Traps against the Abortive Parasite Neospora caninum. | Frontiers in immunology | 68 | 28611772 |
| 2007 | In HIV-1 pathogenesis the die is cast during primary infection. | AIDS (London, England) | 67 | 17148962 |
| 2010 | CAST and ELKS proteins: structural and functional determinants of the presynaptic active zone. | Journal of biochemistry | 64 | 20581014 |
| 1998 | Apparent pore size of polyacrylamide gels: comparison of gels cast and run in Tris-acetate-EDTA and Tris-borate-EDTA buffers. | Electrophoresis | 59 | 9719523 |
| 2011 | Assessment of DNA damage in coal open-cast mining workers using the cytokinesis-blocked micronucleus test and the comet assay. | The Science of the total environment | 58 | 21215992 |
| 1997 | Psychological factors and survival in the cardiac arrhythmia suppression trial (CAST): a reexamination. | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 58 | 9172848 |
| 2008 | Urinary sediment cast scoring index for acute kidney injury: a pilot study. | Nephron. Clinical practice | 57 | 18953176 |
| 2015 | Dogs cast NETs too: Canine neutrophil extracellular traps in health and immune-mediated hemolytic anemia. | Veterinary immunology and immunopathology | 46 | 26574161 |
| 2005 | Rapamycin worsens renal function and intratubular cast formation in protein overload nephropathy. | Kidney international | 45 | 16316336 |
| 2003 | Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice. | Journal of lipid research | 44 | 12588951 |
| 2010 | Impact of viral-mediated IGF-I gene transfer on skeletal muscle following cast immobilization. | American journal of physiology. Endocrinology and metabolism | 43 | 20739512 |
| 2008 | Prion proteostasis: Hsp104 meets its supporting cast. | Prion | 42 | 19242125 |
| 1999 | CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells. | The Journal of biological chemistry | 42 | 10373416 |
| 2015 | Peptidyl-prolyl isomerases: a full cast of critical actors in cardiovascular diseases. | Cardiovascular research | 41 | 25750190 |
| 2002 | Automated image analysis and in situ hybridization as tools to study bacterial populations in food resources, gut and cast of Lumbricus terrestris L. | Journal of microbiological methods | 41 | 11733082 |
| 2006 | Active zone protein CAST is a component of conventional and ribbon synapses in mouse retina. | The Journal of comparative neurology | 40 | 16485285 |
| 2016 | Paraprotein-Related Kidney Disease: Evaluation and Treatment of Myeloma Cast Nephropathy. | Clinical journal of the American Society of Nephrology : CJASN | 39 | 27526708 |
| 2015 | Chitosan-based electrospun nanofibrous mats, hydrogels and cast films: novel anti-bacterial wound dressing matrices. | Journal of materials science. Materials in medicine | 39 | 25716023 |
| 2001 | Role of polymeric Tamm-Horsfall protein in cast formation: oligosaccharide and tubular fluid ions. | Kidney international | 39 | 11231348 |
| 2018 | Myeloma light chain cast nephropathy, a review. | Journal of nephrology | 38 | 29730782 |
| 2006 | RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor. | Molecular and cellular biology | 35 | 16809778 |
| 1995 | Corrosion cast demonstration of retinal vasculature of normal Wistar-Kyoto rats. | Acta anatomica | 34 | 8659253 |
| 2022 | Pollen-pistil interactions: It takes two to tangle but a molecular cast of many to deliver. | Current opinion in plant biology | 33 | 36029655 |
| 2013 | An association between the calpastatin (CAST) gene and keratoconus. | Cornea | 33 | 23449483 |
| 2005 | The physical properties and response of osteoblasts to solution cast films of PLGA doped polycaprolactone. | Biomaterials | 33 | 15935466 |
| 1988 | Myeloma cast nephropathy: immunohistochemical and lectin studies. | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc | 33 | 2467287 |
| 2004 | Osteoblast responses to tape-cast and sintered bioactive glass ceramics. | Journal of biomedical materials research. Part A | 32 | 15162403 |
| 2011 | Somatic gonadal cells: the supporting cast for the germline. | Genesis (New York, N.Y. : 2000) | 31 | 21735540 |
| 2006 | ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+-dependent exocytosis from PC12 cells. | Genes to cells : devoted to molecular & cellular mechanisms | 31 | 16716196 |
| 2018 | Anisotropic freeze-cast collagen scaffolds for tissue regeneration: How processing conditions affect structure and properties in the dry and fully hydrated states. | Journal of the mechanical behavior of biomedical materials | 30 | 30399564 |
| 2013 | Association of polymorphisms at DGAT1, leptin, SCD1, CAPN1 and CAST genes with color, marbling and water holding capacity in meat from beef cattle populations in Sweden. | Meat science | 30 | 23501244 |
| 2018 | Pin1 Promotes Regulated Necrosis Induced by Glutamate in Rat Retinal Neurons via CAST/Calpain2 Pathway. | Frontiers in cellular neuroscience | 29 | 29403356 |
| 2016 | Polymorphisms in metabolism and repair genes affects DNA damage caused by open-cast coal mining exposure. | Mutation research. Genetic toxicology and environmental mutagenesis | 29 | 27637484 |
| 2015 | Competitive allele-specific TaqMan PCR (Cast-PCR) is a sensitive, specific and fast method for BRAF V600 mutation detection in Melanoma patients. | Scientific reports | 29 | 26690267 |
| 2006 | Players in the PARP-1 cell-death pathway: JNK1 joins the cast. | Trends in biochemical sciences | 29 | 16679020 |
| 2003 | The cast of molecular characters in Parkinson's disease: felons, conspirators, and suspects. | Annals of the New York Academy of Sciences | 29 | 12846976 |
| 2018 | Oxidative Stress Contributes to Fracture/Cast-Induced Inflammation and Pain in a Rat Model of Complex Regional Pain Syndrome. | The journal of pain | 28 | 29715519 |
| 2017 | Aggregation of zein in aqueous ethanol dispersions: Effect on cast film properties. | International journal of biological macromolecules | 27 | 28811202 |
| 2013 | Immobilization-induced hypersensitivity associated with spinal cord sensitization during cast immobilization and after cast removal in rats. | The journal of physiological sciences : JPS | 27 | 23818166 |
| 2013 | CAST-ChIP maps cell-type-specific chromatin states in the Drosophila central nervous system. | Cell reports | 27 | 24095734 |
| 2023 | T-CAST: An optimized CAST-Seq pipeline for TALEN confirms superior safety and efficacy of obligate-heterodimeric scaffolds. | Frontiers in genome editing | 25 | 36890979 |
| 2022 | Bile Cast Nephropathy: A Comprehensive Review. | Cureus | 25 | 35505725 |
| 2015 | Functional studies cast light on receptor states. | Trends in pharmacological sciences | 25 | 26123416 |
| 2019 | Cast immobilization of hindlimb upregulates sarcolipin expression in atrophied skeletal muscles and increases thermogenesis in C57BL/6J mice. | American journal of physiology. Regulatory, integrative and comparative physiology | 24 | 31433681 |
| 2018 | Time-course study of macrophage infiltration and inflammation in cast immobilization-induced atrophied muscle of mice. | Muscle & nerve | 24 | 29315666 |
| 2010 | Management options for cast nephropathy in multiple myeloma. | Current opinion in nephrology and hypertension | 24 | 20827195 |
| 2023 | T cells: an emerging cast of roles in bipolar disorder. | Translational psychiatry | 22 | 37156764 |
| 2020 | Presynaptic development is controlled by the core active zone proteins CAST/ELKS. | The Journal of physiology | 22 | 32304329 |
| 2020 | An Eclectic Cast of Cellular Actors Orchestrates Innate Immune Responses in the Mechanisms Driving Obesity and Metabolic Perturbation. | Circulation research | 21 | 32437306 |
| 2005 | Multiple genetic loci from CAST/EiJ chromosome 1 affect vBMD either positively or negatively in a C57BL/6J background. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research | 21 | 16355278 |
| 1986 | The biocompatibility of solution cast and acetone-extracted cast Biomer. | Journal of biomedical materials research | 21 | 3722215 |
| 2016 | SAD-B Phosphorylation of CAST Controls Active Zone Vesicle Recycling for Synaptic Depression. | Cell reports | 19 | 27626661 |
| 2021 | Axonal Injuries Cast Long Shadows: Long Term Glial Activation in Injured and Contralateral Retinas after Unilateral Axotomy. | International journal of molecular sciences | 17 | 34445225 |
| 2013 | A new single nucleotide polymorphism in the calpastatin (CAST) gene associated with beef tenderness. | Meat science | 17 | 24200570 |
| 2022 | Wear Resistance and Biocompatibility of Co-Cr Dental Alloys Fabricated with CAST and SLM Techniques. | Materials (Basel, Switzerland) | 16 | 35591597 |
| 2019 | The influence of polymorphisms of xenobiotic-metabolizing and DNA repair genes in DNA damage, telomere length and global DNA methylation evaluated in open-cast coal mining workers. | Ecotoxicology and environmental safety | 16 | 31787382 |
| 2016 | The active zone protein CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampus. | The European journal of neuroscience | 16 | 27422015 |
| 2013 | Are the B cells cast with the leading part in the Sjogren's syndrome scenario? | Oral diseases | 16 | 23837848 |
| 2007 | The active zone protein CAST directly associates with Ligand-of-Numb protein X. | Biochemical and biophysical research communications | 16 | 17257582 |
| 2004 | JTE-522, a selective COX-2 inhibitor, interferes with the growth of lung metastases from colorectal cancer in rats due to inhibition of neovascularization: a vascular cast model study. | International journal of cancer | 15 | 15386343 |
| 2015 | Clinical pathway for early discharge after complete primary repair of exstrophy and epispadias by using a spica cast. | Journal of pediatric urology | 14 | 25982019 |
| 2007 | Detecting novel bone density and bone size quantitative trait loci using a cross of MRL/MpJ and CAST/EiJ inbred mice. | Calcified tissue international | 14 | 17308992 |
| 2023 | CRISPR-Cas12a test strip (CRISPR/CAST) package: In-situ detection of Brucella from infected livestock. | BMC veterinary research | 13 | 37833763 |
| 2017 | CAST: Its molecular structure and phosphorylation-dependent regulation of presynaptic plasticity. | Neuroscience research | 13 | 29275163 |
| 2015 | Investigation of a solvent-cast organogel to form a liquid-gel microinterface array for electrochemical detection of lysozyme. | Analytica chimica acta | 13 | 26398420 |
| 2014 | Identification of PRL1 as a novel diagnostic and therapeutic target for castration-resistant prostate cancer by the Escherichia coli ampicillin secretion trap (CAST) method. | Urologic oncology | 13 | 24968948 |
| 2018 | Effects of polymorphisms in CAPN1 and CAST genes on meat tenderness of Chinese Simmental cattle. | Archives animal breeding | 12 | 32175450 |
| 1995 | Engineering the right membranes for electrodes at the biological interface; solvent cast and electropolymerised. | Biosensors & bioelectronics | 12 | 7734119 |
| 2024 | Genome editing using CRISPR, CAST, and Fanzor systems. | Molecules and cells | 11 | 38909984 |
| 2022 | In vitro and in vivo assessment of squeeze-cast Mg-Zn-Ca-Mn alloys for biomedical applications. | Acta biomaterialia | 11 | 35914693 |
| 2019 | One week, but not 12 hours, of cast immobilization alters promotor DNA methylation patterns in the nNOS gene in mouse skeletal muscle. | The Journal of physiology | 11 | 31490543 |
| 2005 | Quality control: another player joins the ERAD cast. | Current biology : CB | 11 | 16332527 |
| 1993 | Topography of short portal vessels in the rat pituitary gland: a scanning electron-microscopic and morphometric study of corrosion cast replicas. | Cell and tissue research | 11 | 8481959 |
| 2022 | Association of single nucleotide polymorphisms in the CAPN, CAST, LEP, GH, and IGF-1 genes with growth parameters and ultrasound characteristics of the Longissimus dorsi muscle in Colombian hair sheep. | Tropical animal health and production | 10 | 35088174 |
| 2021 | Fibrin airway cast obstruction: Experience, classification, and treatment guideline from Denver. | Pediatric pulmonology | 10 | 34713989 |
| 2019 | A novel homozygous nonsense mutation in CAST associated with PLACK syndrome. | Cell and tissue research | 10 | 31392520 |
| 2014 | Treatment of acute kidney injury with cast nephropathy. | Clinical nephrology | 10 | 24725380 |
| 2012 | Association of CAST gene polymorphisms with carcass and meat quality traits in Yanbian cattle of China. | Molecular biology reports | 10 | 23086304 |