- Length
- 1663 aa
- Mass
- 187.1 kDa
- Annotated
- 2026-04-28
130 papers in source corpus
Mechanistic narrative
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Mechanism profile
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Source papers
Stage 0 corpus · 130 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2013 | Discovery and refinement of loci associated with lipid levels. | Nature genetics | 2409 | 24097068 |
| 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Proceedings of the National Academy of Sciences of the United States of America | 1479 | 12477932 |
| 2003 | Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. | Nature biotechnology | 1176 | 12754519 |
| 2015 | The BioPlex Network: A Systematic Exploration of the Human Interactome. | Cell | 1118 | 26186194 |
| 2017 | Architecture of the human interactome defines protein communities and disease networks. | Nature | 1085 | 28514442 |
| 2020 | A reference map of the human binary protein interactome. | Nature | 849 | 32296183 |
| 2018 | VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. | Cell discovery | 829 | 29507755 |
| 2003 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | Nature genetics | 754 | 14702039 |
| 2004 | The complement system in regulation of adaptive immunity. | Nature immunology | 736 | 15454921 |
| 1988 | Molecular organization and function of the complement system. | Annual review of biochemistry | 716 | 3052276 |
| 2021 | Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. | Cell | 705 | 33961781 |
| 2007 | Complement C3 variant and the risk of age-related macular degeneration. | The New England journal of medicine | 690 | 17634448 |
| 2011 | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Briefings in bioinformatics | 656 | 21873635 |
| 2013 | Seven new loci associated with age-related macular degeneration. | Nature genetics | 649 | 23455636 |
| 1978 | Chemotactic response to human C3a and C5a anaphylatoxins. I. Evaluation of C3a and C5a leukotaxis in vitro and under stimulated in vivo conditions. | Journal of immunology (Baltimore, Md. : 1950) | 640 | 342601 |
| 2011 | Antimicrobial peptides: key components of the innate immune system. | Critical reviews in biotechnology | 565 | 22074402 |
| 1977 | The role of membrane receptors for C3b and C3d in phagocytosis. | The Journal of experimental medicine | 535 | 833545 |
| 2006 | Drusen complement components C3a and C5a promote choroidal neovascularization. | Proceedings of the National Academy of Sciences of the United States of America | 534 | 16452172 |
| 1969 | Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and description of an anaphylatoxin inactivator of human serum. | The Journal of experimental medicine | 475 | 5778786 |
| 2006 | CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens. | Cell | 454 | 16530040 |
| 2011 | Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. | Nature | 445 | 21979047 |
| 2004 | The lectin-complement pathway--its role in innate immunity and evolution. | Immunological reviews | 443 | 15199963 |
| 2005 | Structures of complement component C3 provide insights into the function and evolution of immunity. | Nature | 439 | 16177781 |
| 2012 | Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies. | Kidney international | 436 | 22456601 |
| 2010 | Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. | Proceedings of the National Academy of Sciences of the United States of America | 433 | 20385819 |
| 2022 | OpenCell: Endogenous tagging for the cartography of human cellular organization. | Science (New York, N.Y.) | 432 | 35271311 |
| 1985 | Human complement component C3: cDNA coding sequence and derived primary structure. | Proceedings of the National Academy of Sciences of the United States of America | 411 | 2579379 |
| 2009 | Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. | Immunological reviews | 400 | 19290921 |
| 1984 | Human neutrophils increase expression of C3bi as well as C3b receptors upon activation. | The Journal of clinical investigation | 392 | 6209300 |
| 2003 | Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. | The Journal of clinical endocrinology and metabolism | 388 | 12679444 |
| 1981 | Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3. | The Journal of experimental medicine | 381 | 6912277 |
| 2010 | Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). | Proceedings of the National Academy of Sciences of the United States of America | 376 | 20385826 |
| 2003 | The proinflammatory mediators C3a and C5a are essential for liver regeneration. | The Journal of experimental medicine | 335 | 12975457 |
| 2006 | Structure of C3b reveals conformational changes that underlie complement activity. | Nature | 295 | 17051160 |
| 2000 | A role for the C3a anaphylatoxin receptor in the effector phase of asthma. | Nature | 278 | 10984054 |
| 1983 | Fibronectin and serum amyloid P component stimulate C3b- and C3bi-mediated phagocytosis in cultured human monocytes. | The Journal of experimental medicine | 259 | 6225825 |
| 1987 | Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins. | The Journal of experimental medicine | 258 | 2951479 |
| 2011 | Complement fragment C3a controls mutual cell attraction during collective cell migration. | Developmental cell | 249 | 22118769 |
| 2006 | Structure of C3b in complex with CRIg gives insights into regulation of complement activation. | Nature | 192 | 17051150 |
| 2007 | C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. | Nature | 187 | 17322907 |
| 1983 | Human platelet activation by C3a and C3a des-arg. | The Journal of experimental medicine | 184 | 6604123 |
| 2002 | Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N. | Microbiology and immunology | 177 | 11939578 |
| 2002 | Complement c3a and c5a induce different signal transduction cascades in endothelial cells. | Journal of immunology (Baltimore, Md. : 1950) | 175 | 12165538 |
| 1981 | Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional properties. | Biochemistry | 170 | 7284336 |
| 2008 | A new map of glycosaminoglycan and C3b binding sites on factor H. | Journal of immunology (Baltimore, Md. : 1950) | 168 | 18684951 |
| 1994 | Complement peptides C3a- and C5a-induced mediator release from dissociated human skin mast cells. | The Journal of investigative dermatology | 168 | 7513741 |
| 1975 | Third component of complement (C3): structural properties in relation to functions. | Proceedings of the National Academy of Sciences of the United States of America | 165 | 1056006 |
| 1983 | Generation of C3a anaphylatoxin from human C3 by human mast cell tryptase. | Journal of immunology (Baltimore, Md. : 1950) | 158 | 6339618 |
| 2002 | Influence of C3 deficiency on atherosclerosis. | Circulation | 144 | 12081998 |
| 1983 | Genetic regulation of a structural polymorphism of human C3b receptor. | The Journal of clinical investigation | 140 | 6223944 |
| 1975 | Human anaphylatoxin (C3a) from the third component of complement. Primary structure. | The Journal of biological chemistry | 139 | 1238393 |
| 1999 | Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells. | Glia | 120 | 10340761 |
| 1981 | Membrane distribution and adsorptive endocytosis by C3b receptors on human polymorphonuclear leukocytes. | The Journal of experimental medicine | 119 | 7252422 |
| 2012 | A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function. | Blood | 118 | 22246034 |
| 2002 | An anti-C3b(i) mAb enhances complement activation, C3b(i) deposition, and killing of CD20+ cells by rituximab. | Blood | 114 | 12393727 |
| 1981 | Characterization of the human complement (c3b) receptor with a fluid phase C3b dimer. | Journal of immunology (Baltimore, Md. : 1950) | 113 | 7276561 |
| 1985 | Human C3b- and C4b-regulatory proteins: a new multi-gene family. | Immunology today | 110 | 25289982 |
| 1977 | Biosynthesis of the third component of complement (C3) in vitro by monocytes from both normal and homozygous C3-deficient humans. | The Journal of clinical investigation | 110 | 332718 |
| 2016 | Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia. | Brain : a journal of neurology | 105 | 27956400 |
| 1975 | Purification and partial characterization of human and porcine C3a anaphylatoxin. | The Journal of biological chemistry | 102 | 803505 |
| 1980 | Purification of the human complement control protein C3b inactivator. | The Biochemical journal | 100 | 6451220 |
| 2017 | Complement C3a signaling facilitates skeletal muscle regeneration by regulating monocyte function and trafficking. | Nature communications | 94 | 29233958 |
| 2016 | Characterization of a functional C3A liver spheroid model. | Toxicology research | 94 | 27746894 |
| 1985 | Deposition of C3b and iC3b onto particulate activators of the human complement system. Quantitation with monoclonal antibodies to human C3. | The Journal of experimental medicine | 93 | 2409200 |
| 2000 | Activated human T lymphocytes express a functional C3a receptor. | Journal of immunology (Baltimore, Md. : 1950) | 91 | 11086104 |
| 1992 | Biosynthesis and secretion of complement component (C3) by activated human polymorphonuclear leukocytes. | Journal of immunology (Baltimore, Md. : 1950) | 90 | 1500721 |
| 1979 | Action of the C3b-inactivator on the cell-bound C3b. | Journal of immunology (Baltimore, Md. : 1950) | 86 | 448074 |
| 2014 | Histopathology of MPGN and C3 glomerulopathies. | Nature reviews. Nephrology | 84 | 25447133 |
| 1992 | A mechanism of action for anaphylatoxin C3a stimulation of mast cells. | Journal of immunology (Baltimore, Md. : 1950) | 83 | 1373170 |
| 1999 | Regulation of IL-6 synthesis in human peripheral blood mononuclear cells by C3a and C3a(desArg). | Journal of immunology (Baltimore, Md. : 1950) | 79 | 9886419 |
| 1987 | The superfamily of C3b/C4b-binding proteins. | Federation proceedings | 78 | 2952524 |
| 2013 | Eculizumab and recurrent C3 glomerulonephritis. | Pediatric nephrology (Berlin, Germany) | 74 | 23689905 |
| 2022 | Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy. | Journal of the American Society of Nephrology : JASN | 73 | 35777783 |
| 2011 | Improvement of HepG2/C3a cell functions in a microfluidic biochip. | Biotechnology and bioengineering | 73 | 21337338 |
| 1985 | Mouse monoclonal antibodies to the human C3b receptor. | Molecular immunology | 73 | 3160931 |
| 2005 | The C3a receptor antagonist SB 290157 has agonist activity. | Immunology letters | 72 | 16154494 |
| 2009 | Nociceptive sensitization by complement C5a and C3a in mouse. | Pain | 70 | 20031321 |
| 2004 | The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. | The Journal of clinical investigation | 68 | 15286806 |
| 2016 | Towards engineering carboxysomes into C3 plants. | The Plant journal : for cell and molecular biology | 63 | 26867858 |
| 1996 | Extrahepatic secreted complement C3 contributes to circulating C3 levels in humans. | Journal of immunology (Baltimore, Md. : 1950) | 62 | 8609428 |
| 2010 | Complement fragments C3a and C5a: the salt and pepper of the immune response. | European journal of immunology | 60 | 20186746 |
| 1983 | The human C3b receptor. | Springer seminars in immunopathology | 60 | 6227098 |
| 1998 | Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells. | The Journal of infectious diseases | 56 | 9607842 |
| 2016 | C3 Glomerulopathy. | Pediatric nephrology (Berlin, Germany) | 55 | 27056062 |
| 1987 | Alternative complement pathway activation fragment Ba binds to C3b. Evidence that formation of the factor B-C3b complex involves two discrete points of contact. | The Journal of biological chemistry | 55 | 3643213 |
| 2013 | C3a, C5a renal expression and their receptors are correlated to severity of IgA nephropathy. | Journal of clinical immunology | 54 | 24327134 |
| 2006 | The structure of complement C3b provides insights into complement activation and regulation. | Nature | 54 | 17051152 |
| 1983 | C3 convertase of the alternative complement pathway. Demonstration of an active, stable C3b, Bb (Ni) complex. | The Journal of biological chemistry | 53 | 6553050 |
| 2020 | The Complement C3a and C3a Receptor Pathway in Kidney Diseases. | Frontiers in immunology | 52 | 32973774 |
| 1998 | Expression of a functional anaphylatoxin C3a receptor by astrocytes. | Journal of neurochemistry | 52 | 9832147 |
| 1983 | Enzymic assay of C3b receptor on intact cells and solubilized cells. | The Biochemical journal | 49 | 6222733 |
| 2004 | Human monocyte-derived dendritic cells are chemoattracted to C3a after up-regulation of the C3a receptor with interferons. | Immunology | 48 | 15056381 |
| 1991 | Internalization pathway of C3b receptors in human neutrophils and its transmodulation by chemoattractant receptors stimulation. | Cell regulation | 48 | 1826092 |
| 2014 | Photosynthesis of C3, C3-C4, and C4 grasses at glacial CO2. | Journal of experimental botany | 46 | 24723409 |
| 2014 | Activation of C3a receptor is required in cigarette smoke-mediated emphysema. | Mucosal immunology | 45 | 25465103 |
| 2009 | Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice. | Journal of immunology (Baltimore, Md. : 1950) | 45 | 19684087 |
| 2011 | Expression of complement component 3 (C3) from an adenovirus leads to pathology in the murine retina. | Investigative ophthalmology & visual science | 43 | 21357400 |
| 1998 | Anaphylatoxin C3a but not C3a(desArg) is a chemotaxin for the mouse macrophage cell line J774. | European journal of immunology | 42 | 9603462 |
| 2017 | Characterization of C3 in C3 glomerulopathy. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association | 41 | 27507892 |
| 2006 | Antifungal activity of C3a and C3a-derived peptides against Candida. | Biochimica et biophysica acta | 41 | 17169328 |
| 2011 | Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury. | Kidney international | 40 | 21677637 |
| 2003 | Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin. | The Journal of biological chemistry | 40 | 12871936 |
| 2015 | Complement Peptide C3a Promotes Astrocyte Survival in Response to Ischemic Stress. | Molecular neurobiology | 38 | 25972241 |
| 2006 | Induction of C3 and CCL2 by C3a in keratinocytes: a novel autocrine amplification loop of inflammatory skin reactions. | Journal of immunology (Baltimore, Md. : 1950) | 38 | 16982879 |
| 2005 | Complement C3a enhances CXCL12 (SDF-1)-mediated chemotaxis of bone marrow hematopoietic cells independently of C3a receptor. | Journal of immunology (Baltimore, Md. : 1950) | 37 | 16148115 |
| 1986 | Hematologic correlates and the role of erythrocyte CR1 (C3b receptor) in the development of AIDS. | AIDS research | 37 | 2944517 |
| 2016 | Glycine decarboxylase in C3, C4 and C3-C4 intermediate species. | Current opinion in plant biology | 36 | 27038285 |
| 2007 | Defining targets for complement components C4b and C3b on the pathogenic neisseriae. | Infection and immunity | 36 | 17984207 |
| 1980 | Control of serum C3 levels by beta 1H and C3b inactivator. | The Journal of laboratory and clinical medicine | 36 | 6445926 |
| 1993 | Characterization of C3a anaphylatoxin receptor on guinea-pig macrophages. | Immunology | 35 | 8406589 |
| 1996 | Regulation of alternative pathway activation and C3a production by adipose cells. | Obesity research | 34 | 8946437 |
| 2021 | Increased ratios of complement factors C3a to C3 in aqueous humor and serum mark glaucoma progression. | Experimental eye research | 33 | 33493474 |
| 2021 | The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases. | Frontiers in immunology | 32 | 33936031 |
| 2019 | C3a and suPAR drive versican V1 expression in tubular cells of focal segmental glomerulosclerosis. | JCI insight | 32 | 30944246 |
| 2007 | Crystallography: crystallographic evidence for deviating C3b structure. | Nature | 32 | 17687277 |
| 2019 | Complement C3a promotes proliferation, migration and stemness in cutaneous squamous cell carcinoma. | Journal of cellular and molecular medicine | 31 | 30825266 |
| 2014 | Vimentin mediates uptake of C3 exoenzyme. | PloS one | 31 | 24967582 |
| 2002 | Albutensin A and complement C3a decrease food intake in mice. | Peptides | 30 | 11814627 |
| 2010 | CNS-specific expression of C3a and C5a exacerbate demyelination severity in the cuprizone model. | Molecular immunology | 29 | 20813409 |
| 1987 | Phylogeny of C4b-C3b cleaving activity: similar fragmentation patterns of human C4b and C3b produced by lower animals. | Journal of immunology (Baltimore, Md. : 1950) | 29 | 3295051 |
| 2020 | Protective Role of C3aR (C3a Anaphylatoxin Receptor) Against Atherosclerosis in Atherosclerosis-Prone Mice. | Arteriosclerosis, thrombosis, and vascular biology | 28 | 32762445 |
| 2015 | Properdin Contributes to Allergic Airway Inflammation through Local C3a Generation. | Journal of immunology (Baltimore, Md. : 1950) | 28 | 26116506 |
| 2010 | Selective hexapeptide agonists and antagonists for human complement C3a receptor. | Journal of medicinal chemistry | 28 | 20527893 |
| 1988 | C3 receptors on macrophages. | Journal of cell science. Supplement | 28 | 2978518 |
| 2022 | Involvement of complement peptides C3a and C5a in osteoarthritis pathology. | Peptides | 27 | 35598724 |
| 2019 | Deficiency of C3a receptor attenuates the development of diabetic nephropathy. | BMJ open diabetes research & care | 27 | 31798904 |
| 2016 | C3 glomerulopathy and current dilemmas. | Clinical and experimental nephrology | 27 | 27878657 |
| 2013 | C3 nephritic factor associated with C3 glomerulopathy in children. | Pediatric nephrology (Berlin, Germany) | 27 | 24068526 |
| 1982 | Biotinylation of human C3. | Molecular immunology | 27 | 7121468 |
| 2013 | C3 glomerulopathy. | Contributions to nephrology | 26 | 23689580 |