Affinage

CFI

Complement factor I · UniProt P05156

Length
583 aa
Mass
65.8 kDa
Annotated
2026-06-09
100 papers in source corpus 9 papers cited in narrative 9 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CFI (complement factor I) is the master proteolytic regulator of the complement system, acting as the negative-feedback brake on the C3b amplification loop that drives the alternative pathway (PMID:4632688). It is a two-chain serine protease whose light chain carries the catalytic triad (His380-Asp429-Ser525); it downregulates both the alternative and classical pathways by cleaving the α' chains of C3b and C4b in the presence of soluble cofactor proteins such as factor H, converting C3b to iC3b and thereby preventing uncontrolled complement amplification (PMID:17597211, PMID:36643920). Catalysis depends on integrity of the active site (His380 is an essential catalytic residue) and on correct substrate recognition, since a C3 variant resistant to cleavage escapes CFI/CFH regulation (PMID:28942469, PMID:24036952). Disease-associated variants act through multiple mechanistic classes: reduced protein secretion (quantitative loss), loss of catalytic/cofactor activity (qualitative loss), and a dominant-negative mechanism in which catalytically inactive FI competitively inhibits wild-type FI within the C3b:FH:FI ternary complex (PMID:17597211, PMID:32908800, PMID:36643920). Loss-of-function is the predominant direction of effect among disease-associated CFI alleles in age-related macular degeneration and aHUS, with reduced C3b regulatory activity tracking with pathogenicity (PMID:23685748, PMID:28282489, PMID:32908800).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 1973 High

    Established that CFI is the physiological brake on complement by showing its removal triggers spontaneous, C3-dependent activation of the alternative pathway, defining the C3b-feedback loop it controls.

    Evidence Immunochemical depletion of CFI from serum with F(ab')2 antibody and in vitro complement activation assays

    PMID:4632688

    Open questions at the time
    • Did not resolve the molecular nature of CFI as a protease
    • No identification of cofactor requirements
    • No structural or substrate-level mechanism
  2. 2007 High

    Defined CFI as a two-chain serine protease cleaving C3b and C4b with cofactor proteins, and showed disease mutations separate catalytic loss from secretion defects.

    Evidence Recombinant expression of CFI mutants with C3b/C4b cofactor cleavage and secretion assays

    PMID:17597211

    Open questions at the time
    • Catalytic triad residues not directly mapped functionally here
    • Mechanism by which heavy-chain R299 contributes to cofactor activity unresolved
    • No real-time kinetics of the cofactor complex
  3. 2013 High

    Linked rare CFI loss-of-function variants to disease by showing reduced secretion and impaired C3b degradation, with in vivo confirmation in zebrafish.

    Evidence Recombinant protein/secretion quantification, serum C3b-degradation assays, and zebrafish retinal vascular assay with human CFI mRNA

    PMID:23685748

    Open questions at the time
    • Zebrafish retinal assay is a surrogate for human CFI activity
    • Does not distinguish secretion from catalytic contributions to the deficit
  4. 2013 Medium

    Demonstrated CFI regulation requires proper substrate recognition, since a cleavage-resistant C3 variant escapes CFI/CFH-mediated inactivation.

    Evidence Functional proteolytic inactivation assay of C3b variants with CFH and CFI

    PMID:24036952

    Open questions at the time
    • Single-lab functional assay
    • Structural basis of the substrate determinant not defined
    • Effect studied from the substrate side, not CFI mutations
  5. 2017 Medium

    Systematically established loss-of-function as the predominant direction of effect for disease-associated CFI alleles by screening many variants in vivo.

    Evidence Targeted CFI sequencing and injection of variant human CFI mRNA into zebrafish with a retinal vascular surrogate assay

    PMID:28282489

    Open questions at the time
    • Zebrafish surrogate may not capture human-specific cofactor interactions
    • Mechanism (secretion vs catalysis) per variant not resolved
    • Single-lab assay
  6. 2017 Medium

    Identified His380 as an essential catalytic-triad residue by linking a homozygous His380Arg mutation to complete CFI deficiency.

    Evidence CFI sequencing and serum complement functional testing in patients with homozygous mutations

    PMID:28942469

    Open questions at the time
    • Single case report
    • No recombinant kinetic confirmation of the catalytic role
    • Other triad residues not tested in this study
  7. 2020 Medium

    Resolved that CFI pathogenic variants act through three distinct mechanistic classes spanning quantitative (protein level) and qualitative (catalytic efficiency) defects.

    Evidence Serum FI-mediated C3b-to-iC3b cleavage assays with factor H cofactor plus ELISA for FI antigen in patient and control sera

    PMID:32908800

    Open questions at the time
    • Single-lab serum-based classification
    • Molecular basis of the Type 3 iC3b-generation defect unresolved
    • No structural correlates for each class
  8. 2022 High

    Established a dominant-negative mechanism whereby catalytically inactive CFI competitively inhibits wild-type FI within the C3b:FH:FI complex.

    Evidence Fully processed recombinant FI (IRES-Furin-CFI), S525A active-site mutagenesis, and real-time SPR competition assays of the C3b:FH:FI complex

    PMID:36643920

    Open questions at the time
    • Tested for specific variants (e.g., I340T); generality across all loss-of-function alleles not established
    • In vivo relevance of competition not demonstrated
    • Stoichiometry of inhibition in plasma not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CFI is recruited to and oriented within the C3b:cofactor complex at atomic resolution, and which variants act by secretion loss versus catalytic loss versus dominant-negative competition, remains incompletely mapped.
  • No structural model linking heavy-chain residues (e.g., R299) to cofactor binding in the timeline
  • Per-variant mechanistic assignment incomplete
  • Cofactor-dependent allosteric activation mechanism not resolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 3 GO:0016787 hydrolase activity 2 GO:0098772 molecular function regulator activity 2
Localization
GO:0005576 extracellular region 2
Pathway
R-HSA-168256 Immune System 2
Partners
C3C4BCFH
Complex memberships
C3b:FH:FI ternary complex

Evidence

Reading pass · 9 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1973 Immunochemical depletion of C3b inactivator (KAF/CFI) from serum leads to spontaneous activation of the alternative complement pathway, with conversion of C3 and depletion of cobra venom factor–C3 proactivator. This activation was prevented by co-depletion of C3, demonstrating that the alternative pathway is a C3b-feedback pathway normally controlled by CFI activity. Immunochemical depletion of CFI from serum using purified F(ab')2 antibody; in vitro complement activation assays Immunology High 4632688
2007 CFI is a two-chain serine protease whose light chain carries the catalytic domain; it downregulates the alternative and classical complement pathways by cleaving the alpha' chains of C3b and C4b in the presence of cofactor proteins (cofactor activity). aHUS-associated mutations I322T, D501N, and D506V in the serine protease domain abolish C3b and C4b cofactor activity despite producing secreted protein. The R299W heavy-chain mutant shows decreased cofactor activity, providing evidence that the heavy chain region around R299 is important for cofactor activity. The delTTCAC (1446-1450) mutant produces a protein that is not secreted. Recombinant expression of mutant CFI proteins; functional cofactor cleavage assays with C3b and C4b; secretion assays Molecular immunology High 17597211
2013 The rare missense CFI variant encoding p.Gly119Arg reduces CFI protein expression and secretion levels, and plasma/sera from carriers mediate degradation of C3b (both in fluid phase and on cell surface) to a lesser extent than controls. In zebrafish, human CFI mRNA encoding Arg119 had reduced activity compared to wild-type Gly119 in regulating retinal vessel thickness and branching. Recombinant protein expression and secretion quantification; functional C3b degradation assays in plasma/sera; zebrafish in vivo vascular assay with human CFI mRNA injection Nature genetics High 23685748
2013 A rare C3 allele encoding Gln155 (p.Lys155Gln) confers resistance to proteolytic inactivation by CFH and CFI, demonstrating that CFI's regulatory function requires proper C3 substrate recognition and that loss of this regulation leads to excessive alternative complement activation. Functional proteolytic inactivation assay of C3b variants with CFH and CFI Nature genetics Medium 24036952
2017 Systematic in vivo functional testing of 20 rare coding nonsynonymous CFI variants in zebrafish identified nine variants that alter CFI activity; six are specifically associated with hypoactive complement factor I, demonstrating that loss-of-function is the predominant direction of effect of disease-associated CFI alleles in AMD. Targeted sequencing of CFI; injection of variant human CFI mRNA into zebrafish embryos; in vivo retinal vascular assay as surrogate for CFI activity Investigative ophthalmology & visual science Medium 28282489
2017 Complete CFI deficiency caused by a homozygous p.His380Arg mutation affecting the catalytic triad histidine residue (His380, part of the His380-Asp429-Ser525 catalytic triad) results in loss of protein function, identifying His380 as an essential catalytic residue of the CFI serine protease active site. CFI gene sequencing; serum complement functional testing in patients with homozygous CFI mutations; identification of catalytic triad residue Journal of clinical immunology Medium 28942469
2020 Rare CFI genetic variants were categorized functionally into three types: Type 1 variants cause low serum FI protein levels with correspondingly reduced C3b cleavage activity; Type 2 variants show normal FI antigen levels but reduced C3b-to-iC3b degradation; Type 3 variants show normal antigen levels and C3b degradation but low iC3b generation per unit FI. This demonstrates that CFI pathogenic variants act through either quantitative (protein level) or qualitative (catalytic efficiency) mechanisms. Serum-based functional assay measuring FI-mediated proteolytic cleavage of C3b to iC3b with Factor H as cofactor; ELISA for FI antigen levels in patient and control sera Translational vision science & technology Medium 32908800
2022 Using a fully processed recombinant CFI produced via an IRES-Furin-CFI expression vector, a surface plasmon resonance assay was developed to characterize the C3b:FH:FI complex in real time. An active-site mutant (S525A FI, inactivated serine protease domain) was used to show that patient-associated inactive CFI variants (e.g., I340T) competitively inhibit wild-type FI function, demonstrating a dominant negative mechanism for certain loss-of-function CFI variants. IRES-Furin-CFI expression for fully processed recombinant FI; active-site mutagenesis (S525A); real-time surface plasmon resonance assay of C3b:FH:FI complex; competition assays with wild-type and variant FI Frontiers in immunology High 36643920
2008 The CFI polymorphism is controlled by two main alleles (CFI*A and CFI*B). CFI*A is composed of two suballeles: CFI*As (R201S substitution) and CFI*Ah (R406H substitution). A rare variant CFI*Aj arises from CFI*Ah with an additional R502L mutation. CFI*As is Japanese-specific, demonstrating that specific missense variants in CFI underlie the serologically defined polymorphism. DNA sequencing of CFI in 174 Japanese subjects and 2,471 individuals from 20 populations; isoelectric focusing; haplotype analysis Journal of human genetics Low 18825487

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. Nature genetics 293 24036952
2006 Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: a retrospective analysis from the French intergroup of CML (Fi(phi)-LMC GROUP). Leukemia 172 16642048
2014 Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent. Cancer cell 164 25043604
2013 A functional variant in the CFI gene confers a high risk of age-related macular degeneration. Nature genetics 162 23685748
1973 The alternate pathway of complement activation. The role of C3 and its inactivator (KAF). Immunology 160 4632688
2011 Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping. Structure (London, England : 1993) 134 21295486
2010 Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing. Proceedings of the National Academy of Sciences of the United States of America 131 20479262
2007 Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome. Molecular immunology 128 17597211
2019 siRNA-Finder (si-Fi) Software for RNAi-Target Design and Off-Target Prediction. Frontiers in plant science 124 31475020
2011 Use of laptop computers connected to internet through Wi-Fi decreases human sperm motility and increases sperm DNA fragmentation. Fertility and sterility 110 22112647
2015 Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels. Human molecular genetics 108 25788521
2017 Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer. Proceedings of the National Academy of Sciences of the United States of America 101 28270606
2018 Wi-Fi is an important threat to human health. Environmental research 79 29573716
1999 Safety and immunogenicity of a Pseudomonas aeruginosa hybrid outer membrane protein F-I vaccine in human volunteers. Infection and immunity 66 10024596
1966 Episome-mediated Transfer of Drug Resistance in Enterobacteriaceae X. Restriction and Modification of Phages by fi R Factors. Journal of bacteriology 64 16562138
2016 Does prolonged radiofrequency radiation emitted from Wi-Fi devices induce DNA damage in various tissues of rats? Journal of chemical neuroanatomy 59 26775760
2015 Investigation of the effects of distance from sources on apoptosis, oxidative stress and cytosolic calcium accumulation via TRPV1 channels induced by mobile phones and Wi-Fi in breast cancer cells. Biochimica et biophysica acta 57 25703814
2015 The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent. Journal of medicinal chemistry 57 25723005
1987 An equine rotavirus (FI-14 strain) which bears both subgroup I and subgroup II specificities on its VP6. Virology 56 2435059
2015 Effects of 2.4 GHz radiofrequency radiation emitted from Wi-Fi equipment on microRNA expression in brain tissue. International journal of radiation biology 55 25775055
2014 Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis through activation of TRPV1 channel in hippocampus and dorsal root ganglion of rats. Metabolic brain disease 54 24792079
2015 Hi-Fi SELEX: A High-Fidelity Digital-PCR Based Therapeutic Aptamer Discovery Platform. Biotechnology and bioengineering 53 25727321
2022 CFI-402257, a TTK inhibitor, effectively suppresses hepatocellular carcinoma. Proceedings of the National Academy of Sciences of the United States of America 50 35914158
2019 Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial. British journal of cancer 47 31303643
2020 Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration. Investigative ophthalmology & visual science 46 32516404
2017 Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts. Oncotarget 45 27902970
2001 Safety and immunogenicity of an intranasal Pseudomonas aeruginosa hybrid outer membrane protein F-I vaccine in human volunteers. Vaccine 45 11257350
2007 Polyadenylation site choice in yeast is affected by competition between Npl3 and polyadenylation factor CFI. RNA (New York, N.Y.) 44 17684230
2019 Adverse Effects of Wi-Fi Radiation on Male Reproductive System: A Systematic Review. The Tohoku journal of experimental medicine 43 31353326
2021 SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A. eLife 42 33949310
2002 Control of neuronal subtype identity by the C. elegans ARID protein CFI-1. Genes & development 42 11959845
1987 A novel in vitro DNA packaging system demonstrating a direct role for the bacteriophage lambda FI gene product. Virology 41 2961121
2012 Immunohistopathologic demonstration of deleterious effects on growing rat testes of radiofrequency waves emitted from conventional Wi-Fi devices. Journal of pediatric urology 40 22465825
2015 Long-term exposure to electromagnetic radiation from mobile phones and Wi-Fi devices decreases plasma prolactin, progesterone, and estrogen levels but increases uterine oxidative stress in pregnant rats and their offspring. Endocrine 38 26578367
1990 Cloning and sequence analysis of a cDNA for cellulase (FI-CMCase) from Aspergillus aculeatus. Current genetics 37 2249253
1988 Bacteriophage lambda DNA packaging. The product of the FI gene promotes the incorporation of the prohead to the DNA-terminase complex. Journal of molecular biology 37 2965251
1973 Chloramphenicol acetyltransferases specified by fi minus R factors. Antimicrobial agents and chemotherapy 37 4597710
2023 Polo-like kinase 4 inhibitor CFI-400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity. Hepatology (Baltimore, Md.) 35 35302667
2020 Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) using a Serum-Based Assay in Advanced Age-related Macular Degeneration. Translational vision science & technology 32 32908800
2012 Eculizumab therapy in a child with hemolytic uremic syndrome and CFI mutation. Pediatric nephrology (Berlin, Germany) 31 22903728
2001 Cloning, expression, and characterization of a chitinase gene from the Antarctic psychrotolerant bacterium Vibrio sp. strain Fi:7. Extremophiles : life under extreme conditions 31 11354455
2012 Quantifying chromatin-associated interactions: the HI-FI system. Methods in enzymology 29 22910210
2014 Baeckeins F-I, four novel C-methylated biflavonoids from the roots of Baeckea frutescens and their anti-inflammatory activities. Food chemistry 28 24594150
2009 Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axis. Leukemia 28 19946262
2008 Myrtucommulones F-I, phloroglucinols with thyrotropin-releasing hormone receptor-2 binding affinity from the seeds of Corymbia scabrida. Journal of natural products 28 18771320
1996 Production of recombinant mite allergen Der fI in insect cells and characterization of products--removal of pro-sequence is essential to IgE-binding activity. Bioscience, biotechnology, and biochemistry 28 8829528
2018 Glypican-1-antibody-conjugated Gd-Au nanoclusters for FI/MRI dual-modal targeted detection of pancreatic cancer. International journal of nanomedicine 27 29750031
2007 A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations. Clinical cancer research : an official journal of the American Association for Cancer Research 27 17671144
1999 Simultaneous determination of paracetamol, caffeine and acetylsalicylic acid by means of a FI ultraviolet pls multioptosensing device. Journal of pharmaceutical and biomedical analysis 26 10703966
2021 Anticancer effects of radiation therapy combined with Polo-Like Kinase 4 (PLK4) inhibitor CFI-400945 in triple negative breast cancer. Breast (Edinburgh, Scotland) 25 33866248
2002 Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues. Bioorganic & medicinal chemistry 25 12110316
2019 A histone H2A derived antimicrobial peptide, Fi-Histin from the Indian White shrimp, Fenneropenaeus indicus: Molecular and functional characterization. Fish & shellfish immunology 24 31252047
1972 Hybridization of variants of chloramphenicol acetyltransferase specified by fi + and fi - R factors. Proceedings of the National Academy of Sciences of the United States of America 24 4628098
2004 Distinctive polymorphism of chicken B-FI (major histocompatibility complex class I) molecules. Poultry science 23 15109057
1983 Nucleotide sequence of a rabbit IgG heavy chain from the recombinant F-I haplotype. Immunogenetics 22 6313520
2018 Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89. Bioorganic & medicinal chemistry 20 29452840
2012 In utero and early-life exposure of rats to a Wi-Fi signal: screening of immune markers in sera and gestational outcome. Bioelectromagnetics 20 22228576
2002 Tissue distribution of different mercurial compounds analyzed by the improved FI-CVAAS. Journal of analytical toxicology 20 12166816
2017 Systematic Functional Testing of Rare Variants: Contributions of CFI to Age-Related Macular Degeneration. Investigative ophthalmology & visual science 19 28282489
1991 Functional insertion of the SV40 large T oncogene in cystic fibrosis intestinal epithelium. Characterization of CFI-3 cells. The Journal of biological chemistry 19 1718974
1979 Studies on proteinases from Calotropis gigantea latex. II. Physico-chemichal properties of calotropain-FI and FII. Biochimica et biophysica acta 19 444538
2016 Application prospective of nanoprobes with MRI and FI dual-modality imaging on breast cancer stem cells in tumor. Journal of nanobiotechnology 18 27339420
2023 Preclinical characterization and clinical trial of CFI-400945, a polo-like kinase 4 inhibitor, in patients with relapsed/refractory acute myeloid leukemia and higher-risk myelodysplastic neoplasms. Leukemia 17 38114624
2023 OncoTherad® (MRB-CFI-1) Nanoimmunotherapy: A Promising Strategy to Treat Bacillus Calmette-Guérin-Unresponsive Non-Muscle-Invasive Bladder Cancer: Crosstalk among T-Cell CX3CR1, Immune Checkpoints, and the Toll-Like Receptor 4 Signaling Pathway. International journal of molecular sciences 17 38139364
2013 Decrease in formalin-inactivated respiratory syncytial virus (FI-RSV) enhanced disease with RSV G glycoprotein peptide immunization in BALB/c mice. PloS one 17 24376637
2020 Anticancer effects of the PLK4 inhibitors CFI-400945 and centrinone in Ewing's sarcoma cells. Journal of cancer research and clinical oncology 16 32770382
2017 The effect of Wi-Fi electromagnetic waves in unimodal and multimodal object recognition tasks in male rats. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 16 28332042
2011 Hi-Fi transmission of periodic signals amid cell-to-cell variability. Molecular bioSystems 16 21559542
2013 Secretory expression of thermostable alkaline protease from Bacillus stearothermophilus FI by using native signal peptide and α-factor secretion signal in Pichia pastoris. Genes & genetic systems 15 23832300
1982 Bacteriophage lambda DNA packaging in vitro. The involvement of the lambda FI gene product, single-strand DNA, and a novel lambda-directed protein in the packaging reaction. The Journal of biological chemistry 15 6279661
2020 The radio-protective effect of rosmarinic acid against mobile phone and Wi-Fi radiation-induced oxidative stress in the brains of rats. Pharmacological reports : PR 14 32128712
2018 Moderate Dose of Trolox Preventing the Deleterious Effects of Wi-Fi Radiation on Spermatozoa In vitro through Reduction of Oxidative Stress Damage. Chinese medical journal 13 29451144
2017 Early Versus Late Diagnosis of Complement Factor I Deficiency: Clinical Consequences Illustrated in Two Families with Novel Homozygous CFI Mutations. Journal of clinical immunology 13 28942469
2010 The effects of acute dynamic exercise on haemostasis in fi rst class Scottish football referees. British journal of sports medicine 13 19019900
2010 [Guidelines for the management of nilotinib (Tasigna)-induced side effects in chronic myelogenous leukemia: recommendations of French Intergroup of CML (Fi-LMC group)]. Bulletin du cancer 13 20529767
1997 Production of recombinant Der fI with the native IgE-binding activity using a baculovirus expression system. Bioscience, biotechnology, and biochemistry 13 9362114
2017 Effects of electromagnetic waves emitted from 3G+wi-fi modems on human semen analysis. Urologia 12 28967061
2014 CFI-rs7356506 is a genetic protective factor for acute anterior uveitis in Chinese patients. The British journal of ophthalmology 12 25075123
2014 Influence of smartphone Wi-Fi signals on adipose-derived stem cells. The Journal of craniofacial surgery 12 25098574
1971 Isolation and properties of RNA replicases induced by SP and FI phages. Proceedings of the National Academy of Sciences of the United States of America 12 5288764
2023 Cell context-dependent CFI-1/ARID3 functions control neuronal terminal differentiation. Cell reports 11 36897776
2023 Electrochemical site-selective direct C-H sulfenylation and selenylation of a chromone-fused-indolizine (CFI) skeleton. Chemical communications (Cambridge, England) 11 37066490
2015 Novel CFI mutation in a patient with leukocytoclastic vasculitis may redefine the clinical spectrum of Complement Factor I deficiency. Clinical immunology (Orlando, Fla.) 11 25988862
2008 Molecular basis of complement factor I (CFI) polymorphism: one of two polymorphic suballeles responsible for CFI A is Japanese-specific. Journal of human genetics 11 18825487
1994 Expression of the cellulase (FI-CMCase) gene of Aspergillus aculeatus in Saccharomyces cerevisiae. Bioscience, biotechnology, and biochemistry 11 7764982
1975 Amplification of sex repressor function of one fi-+ R-factor during anaerobic growth of Escherichia coli. Journal of bacteriology 11 1095555
2022 OncoTherad® (MRB-CFI-1) nano-immunotherapy reduced tumoral progression in non-muscle invasive bladder cancer through activation of Toll-like signaling pathway. Tissue & cell 10 35245856
2022 Role of 2.4 GHz radiofrequency radiation emitted from Wi-Fi on some miRNA and faty acids composition in brain. Electromagnetic biology and medicine 10 35435088
2020 FI-Net: Identification of Cancer Driver Genes by Using Functional Impact Prediction Neural Network. Frontiers in genetics 10 33244318
2019 Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration. Disease markers 10 31583032
2019 Evaluation of Wi-Fi Radiation Effects on Antibiotic Susceptibility, Metabolic Activity and Biofilm Formation by Escherichia Coli 0157H7, Staphylococcus Aureus and Staphylococcus Epidermis. Journal of biomedical physics & engineering 10 31750272
1996 Trypanosoma cruzi cytosolic alkaline antigens (FI) induce polyclonal activation in murine normal B cells. Scandinavian journal of immunology 10 8711435
1993 Expression of the cellulase (FI-CMCase) gene of Aspergillus aculeatus in Escherichia coli. Bioscience, biotechnology, and biochemistry 10 7764343
2019 [Recommendations from the French CML Study Group (Fi-LMC) for BCR-ABL1 kinase domain mutation analysis in chronic myeloid leukemia]. Bulletin du cancer 9 31353136
2016 Crystal structure and genetic modifications of FI-CMCase from Aspergillus aculeatus F-50. Biochemical and biophysical research communications 9 27470581
2011 cDNA cloning, characterization and expression analysis of a novel antimicrobial peptide gene penaeidin-3 (Fi-Pen3) from the haemocytes of Indian white shrimp Fenneropenaeus indicus. Microbiological research 9 21885268
1990 An automated microtechnique for selenium determination in human body fluids by flow injection hydride atomic absorption spectrometry (FI-HAAS). Journal of trace elements and electrolytes in health and disease 9 2135957
1988 Partial FI gene-independence of lambda-21 hybrid phages specifying chimeric terminases. Virology 9 2973176
2022 A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in age-related macular degeneration. Frontiers in immunology 8 36643920
2020 Complement family member CFI polymorphisms and AMD susceptibility from a comprehensive analysis. Bioscience reports 8 32215612

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