Affinage

CFI

Complement factor I · UniProt P05156

Length
583 aa
Mass
65.8 kDa
Annotated
2026-04-28
100 papers in source corpus 9 papers cited in narrative 9 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Complement factor I (CFI) is the principal serine protease responsible for negative regulation of the complement system, controlling both the alternative and classical pathways by cleaving the α′ chains of C3b and C4b in a cofactor-dependent manner. CFI functions as a two-chain protease whose light chain harbors the catalytic triad (His380, Asp429, Ser525) and whose heavy chain also participates in cofactor-dependent substrate recognition; cofactor proteins such as Factor H, C4BP, and CR1 are absolutely required for proteolytic activity, converting C3b to iC3b and preventing uncontrolled C3 consumption (PMID:4632688, PMID:17597211, PMID:28942469). Disease-associated CFI mutations cause loss of function through three distinct mechanisms—reduced protein secretion/antigen levels, impaired catalytic activity with normal secretion, or reduced specific activity per molecule—and these deficiencies are causally linked to atypical hemolytic uremic syndrome and advanced age-related macular degeneration (PMID:25788521, PMID:32908800, PMID:23685748). Immunochemical depletion of CFI from serum triggers spontaneous alternative pathway activation, establishing that the alternative pathway operates as a constitutive C3b-feedback loop held in check by CFI (PMID:4632688).

Mechanistic history

Synthesis pass · year-by-year structured walk · 6 steps
  1. 1973 High

    Resolving whether the alternative complement pathway is constitutively active or triggered: immunochemical removal of CFI from serum demonstrated that the alternative pathway functions as a C3b-positive-feedback loop normally held in check by CFI-mediated C3b inactivation.

    Evidence Immunochemical depletion of KAF (CFI) from human serum followed by complement activation assays

    PMID:4632688

    Open questions at the time
    • Cofactor requirement for CFI cleavage not yet identified
    • Molecular identity and chain structure of CFI not determined
    • Mechanism by which CFI recognizes C3b versus native C3 unknown
  2. 2007 High

    Establishing the domain-level mechanism of CFI catalysis: recombinant mutant analysis showed that the light-chain serine protease domain performs cofactor-dependent cleavage of C3b and C4b, while the heavy chain contributes to substrate/cofactor recognition, as mutations in both chains abolish activity.

    Evidence Recombinant expression of CFI mutants (I322T, D501N, D506V in light chain; R299W in heavy chain) with functional C3b/C4b cofactor activity assays

    PMID:17597211

    Open questions at the time
    • Structural basis for heavy-chain contribution to cofactor-dependent cleavage not resolved
    • Specific cofactor binding sites on CFI not mapped
    • No crystal structure of CFI–cofactor–substrate complex available
  3. 2013 High

    Linking CFI variant dysfunction to disease and substrate specificity: the p.Gly119Arg CFI variant was shown to reduce both secretion and C3b-degrading activity, connecting quantitative and qualitative FI deficiency to complement dysregulation; independently, a C3 substrate variant (p.Lys155Gln) was shown to resist CFI/CFH-mediated cleavage, establishing that CFI activity is substrate-sequence-dependent.

    Evidence Recombinant protein secretion assays, C3b degradation in plasma, zebrafish retinal vascular assay (for CFI variant); reconstituted proteolytic inactivation assay with purified proteins (for C3 variant)

    PMID:23685748 PMID:24036952

    Open questions at the time
    • Structural determinants on C3b recognized by CFI during cleavage not defined
    • Whether substrate sequence variants affect all cofactor-dependent pathways equally is untested
  4. 2015 Medium

    Demonstrating that reduced circulating FI protein level—not merely genetic variant carrier status—is the proximate risk factor for AMD, establishing quantitative FI deficiency as the mechanistic driver.

    Evidence Serum FI ELISA in large cohort of rare CFI variant carriers and non-carriers, statistical association with advanced AMD risk

    PMID:25788521

    Open questions at the time
    • Threshold FI level below which complement dysregulation occurs not defined
    • Whether FI supplementation can rescue AMD phenotype untested
    • Tissue-specific (retinal) FI expression and its contribution not separated from circulating pool
  5. 2017 Medium

    Identifying the catalytic triad and systematically classifying variant effects: a homozygous His380Arg mutation directly confirmed His380 as part of the catalytic triad (His380/Asp429/Ser525), and systematic in vivo testing of 20 rare CFI variants stratified alleles by functional consequence, revealing that multiple rare hypoactive alleles contribute to AMD.

    Evidence Genetic sequencing and complement functional testing of catalytic triad mutant; zebrafish retinal vascularization assay screening 20 CFI variants

    PMID:28282489 PMID:28942469

    Open questions at the time
    • Only one catalytic triad residue mutation characterized; Asp429 and Ser525 mutations not yet reported in patients
    • Zebrafish assay is a surrogate; direct correspondence to human retinal complement regulation assumed but not proven
  6. 2020 Medium

    Establishing a mechanistic classification of CFI variant dysfunction: serum-based assays stratified rare variants into Type 1 (low antigen/low function), Type 2 (normal antigen/reduced cleavage), and Type 3 (normal antigen and cleavage/reduced specific activity), providing a comprehensive framework for genotype–mechanism correlation.

    Evidence Sandwich ELISA for FI antigen combined with Factor H-dependent C3b proteolytic cleavage assay in patient sera

    PMID:32908800

    Open questions at the time
    • Structural basis distinguishing Type 2 from Type 3 dysfunction not determined
    • Whether this classification predicts clinical severity or therapeutic response is untested
    • Assay uses only Factor H as cofactor; behavior with CR1 or C4BP cofactors not assessed

Open questions

Synthesis pass · forward-looking unresolved questions
  • No high-resolution structure of the CFI–cofactor–C3b ternary complex exists, and the molecular basis for how cofactor binding activates CFI catalysis and directs substrate cleavage site specificity remains unresolved.
  • No crystal or cryo-EM structure of CFI in complex with cofactor and substrate
  • Allosteric mechanism by which cofactor binding activates the CFI serine protease domain unknown
  • Whether therapeutic FI supplementation can restore complement regulation in vivo not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 6
Localization
GO:0005576 extracellular region 3
Pathway
R-HSA-168256 Immune System 4
Partners
C3BC4BCFH

Evidence

Reading pass · 9 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1973 Complement factor I (CFI/KAF, C3b inactivator) controls the alternative complement pathway by inactivating C3b; immunochemical depletion of KAF from serum leads to spontaneous alternative pathway activation with conversion of C3, demonstrating that the alternative pathway is essentially a C3b-feedback pathway normally controlled by CFI activity. Immunochemical depletion of KAF using purified F(ab′)2 antibody, in vitro complement activation assays Immunology High 4632688
2007 CFI is a two-chain serine protease whose light chain carries the catalytic domain; it downregulates complement by cleaving the alpha′ chains of C3b and C4b in the presence of cofactor proteins. Disease-associated mutations in the serine protease domain (I322T, D501N, D506V) abolish C3b and C4b cofactor activity, while a heavy-chain mutation (R299W) also reduces cofactor activity, indicating the heavy chain participates in cofactor-dependent cleavage. Recombinant mutant protein expression, functional cofactor activity assays measuring C3b and C4b cleavage Molecular immunology High 17597211
2013 A rare missense CFI variant (p.Gly119Arg) reduces both expression/secretion of FI protein and its activity in degrading C3b (both in fluid phase and on cell surface); reduced CFI mRNA/protein activity was further validated by a zebrafish retinal vascularization assay showing impaired complement regulation. Recombinant protein expression and secretion assays, C3b degradation functional assays in plasma/sera, zebrafish in vivo retinal vascular assay Nature genetics High 23685748
2013 The C3 variant encoding Gln155 (p.Lys155Gln) is resistant to proteolytic inactivation by CFH and CFI, demonstrating that CFI-mediated cleavage of C3b is sequence-dependent and that this variant escapes regulation, leading to excessive alternative complement activation. Functional proteolytic inactivation assay using recombinant/purified proteins with CFH and CFI Nature genetics High 24036952
2015 Rare genetic variants in CFI commonly result in reduced circulating serum Factor I (FI) protein levels; individuals with low FI levels have markedly increased risk of advanced AMD, establishing that quantitative FI deficiency (not merely genetic variant carrier status) is the mechanistic driver of complement dysregulation in AMD. Serum FI ELISA measurement in variant carriers and non-carriers, statistical association of FI levels with AMD risk Human molecular genetics Medium 25788521
2017 Systematic functional testing of 20 rare CFI coding variants in a zebrafish retinal vascularization assay identified nine variants that alter CFI function, six of which are hypoactive (loss of complement regulatory activity), demonstrating that multiple rare alleles contribute to AMD through reduced FI activity. Targeted sequencing of CFI, zebrafish in vivo retinal vascular assay as surrogate for CFI function Investigative ophthalmology & visual science Medium 28282489
2017 Complete CFI deficiency caused by homozygous mutations (p.Gly162Asp and p.His380Arg) abolishes FI protein function; p.His380Arg is the first mutation described affecting a residue of the highly conserved FI catalytic triad (His380, Asp429, Ser525), directly confirming the serine protease catalytic mechanism of CFI. Genetic sequencing of CFI, complement functional testing confirming absent FI activity Journal of clinical immunology Medium 28942469
2020 A serum-based functional assay stratified rare CFI variants into three mechanistic types: Type 1 (low FI antigen and low function), Type 2 (normal antigen but reduced C3b-to-iC3b cleavage in Factor H-dependent assay), and Type 3 (normal antigen and cleavage but reduced activity per unit FI), comprehensively mapping the mechanistic spectrum of CFI variant dysfunction. Sandwich ELISA for FI antigen levels, functional C3b proteolytic cleavage assay using Factor H as cofactor in patient sera Translational vision science & technology Medium 32908800
2008 The molecular basis of CFI polymorphism was established: the CFI*A allele is divided into two suballeles (R201S and R406H substitutions), defining the population genetics and protein sequence variation underlying CFI isoelectric focusing polymorphism. Sequencing of CFI in 2,471 individuals across 20 populations, correlation with isoelectric focusing patterns Journal of human genetics Low 18825487

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. Nature genetics 292 24036952
2006 Mutation status and clinical outcome of 89 imatinib mesylate-resistant chronic myelogenous leukemia patients: a retrospective analysis from the French intergroup of CML (Fi(phi)-LMC GROUP). Leukemia 172 16642048
2013 A functional variant in the CFI gene confers a high risk of age-related macular degeneration. Nature genetics 162 23685748
2014 Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent. Cancer cell 160 25043604
1973 The alternate pathway of complement activation. The role of C3 and its inactivator (KAF). Immunology 160 4632688
2011 Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping. Structure (London, England : 1993) 130 21295486
2010 Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing. Proceedings of the National Academy of Sciences of the United States of America 130 20479262
2007 Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome. Molecular immunology 128 17597211
2019 siRNA-Finder (si-Fi) Software for RNAi-Target Design and Off-Target Prediction. Frontiers in plant science 119 31475020
2011 Use of laptop computers connected to internet through Wi-Fi decreases human sperm motility and increases sperm DNA fragmentation. Fertility and sterility 110 22112647
2015 Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels. Human molecular genetics 107 25788521
2017 Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer. Proceedings of the National Academy of Sciences of the United States of America 100 28270606
2018 Wi-Fi is an important threat to human health. Environmental research 77 29573716
1999 Safety and immunogenicity of a Pseudomonas aeruginosa hybrid outer membrane protein F-I vaccine in human volunteers. Infection and immunity 66 10024596
1966 Episome-mediated Transfer of Drug Resistance in Enterobacteriaceae X. Restriction and Modification of Phages by fi R Factors. Journal of bacteriology 64 16562138
2016 Does prolonged radiofrequency radiation emitted from Wi-Fi devices induce DNA damage in various tissues of rats? Journal of chemical neuroanatomy 59 26775760
2015 Investigation of the effects of distance from sources on apoptosis, oxidative stress and cytosolic calcium accumulation via TRPV1 channels induced by mobile phones and Wi-Fi in breast cancer cells. Biochimica et biophysica acta 57 25703814
2015 The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent. Journal of medicinal chemistry 57 25723005
1987 An equine rotavirus (FI-14 strain) which bears both subgroup I and subgroup II specificities on its VP6. Virology 56 2435059
2015 Effects of 2.4 GHz radiofrequency radiation emitted from Wi-Fi equipment on microRNA expression in brain tissue. International journal of radiation biology 54 25775055
2014 Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis through activation of TRPV1 channel in hippocampus and dorsal root ganglion of rats. Metabolic brain disease 54 24792079
2015 Hi-Fi SELEX: A High-Fidelity Digital-PCR Based Therapeutic Aptamer Discovery Platform. Biotechnology and bioengineering 52 25727321
2022 CFI-402257, a TTK inhibitor, effectively suppresses hepatocellular carcinoma. Proceedings of the National Academy of Sciences of the United States of America 49 35914158
2020 Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration. Investigative ophthalmology & visual science 45 32516404
2019 Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial. British journal of cancer 45 31303643
2001 Safety and immunogenicity of an intranasal Pseudomonas aeruginosa hybrid outer membrane protein F-I vaccine in human volunteers. Vaccine 45 11257350
2017 Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts. Oncotarget 44 27902970
2007 Polyadenylation site choice in yeast is affected by competition between Npl3 and polyadenylation factor CFI. RNA (New York, N.Y.) 44 17684230
2021 SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A. eLife 42 33949310
2019 Adverse Effects of Wi-Fi Radiation on Male Reproductive System: A Systematic Review. The Tohoku journal of experimental medicine 42 31353326
2002 Control of neuronal subtype identity by the C. elegans ARID protein CFI-1. Genes & development 41 11959845
1987 A novel in vitro DNA packaging system demonstrating a direct role for the bacteriophage lambda FI gene product. Virology 41 2961121
2012 Immunohistopathologic demonstration of deleterious effects on growing rat testes of radiofrequency waves emitted from conventional Wi-Fi devices. Journal of pediatric urology 40 22465825
2015 Long-term exposure to electromagnetic radiation from mobile phones and Wi-Fi devices decreases plasma prolactin, progesterone, and estrogen levels but increases uterine oxidative stress in pregnant rats and their offspring. Endocrine 38 26578367
1990 Cloning and sequence analysis of a cDNA for cellulase (FI-CMCase) from Aspergillus aculeatus. Current genetics 37 2249253
1988 Bacteriophage lambda DNA packaging. The product of the FI gene promotes the incorporation of the prohead to the DNA-terminase complex. Journal of molecular biology 37 2965251
1973 Chloramphenicol acetyltransferases specified by fi minus R factors. Antimicrobial agents and chemotherapy 37 4597710
2023 Polo-like kinase 4 inhibitor CFI-400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity. Hepatology (Baltimore, Md.) 34 35302667
2020 Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) using a Serum-Based Assay in Advanced Age-related Macular Degeneration. Translational vision science & technology 32 32908800
2012 Eculizumab therapy in a child with hemolytic uremic syndrome and CFI mutation. Pediatric nephrology (Berlin, Germany) 31 22903728
2001 Cloning, expression, and characterization of a chitinase gene from the Antarctic psychrotolerant bacterium Vibrio sp. strain Fi:7. Extremophiles : life under extreme conditions 31 11354455
2012 Quantifying chromatin-associated interactions: the HI-FI system. Methods in enzymology 29 22910210
2014 Baeckeins F-I, four novel C-methylated biflavonoids from the roots of Baeckea frutescens and their anti-inflammatory activities. Food chemistry 28 24594150
2009 Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axis. Leukemia 28 19946262
2008 Myrtucommulones F-I, phloroglucinols with thyrotropin-releasing hormone receptor-2 binding affinity from the seeds of Corymbia scabrida. Journal of natural products 28 18771320
1996 Production of recombinant mite allergen Der fI in insect cells and characterization of products--removal of pro-sequence is essential to IgE-binding activity. Bioscience, biotechnology, and biochemistry 28 8829528
2018 Glypican-1-antibody-conjugated Gd-Au nanoclusters for FI/MRI dual-modal targeted detection of pancreatic cancer. International journal of nanomedicine 27 29750031
2007 A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations. Clinical cancer research : an official journal of the American Association for Cancer Research 27 17671144
1999 Simultaneous determination of paracetamol, caffeine and acetylsalicylic acid by means of a FI ultraviolet pls multioptosensing device. Journal of pharmaceutical and biomedical analysis 26 10703966
2002 Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues. Bioorganic & medicinal chemistry 25 12110316
2021 Anticancer effects of radiation therapy combined with Polo-Like Kinase 4 (PLK4) inhibitor CFI-400945 in triple negative breast cancer. Breast (Edinburgh, Scotland) 24 33866248
1972 Hybridization of variants of chloramphenicol acetyltransferase specified by fi + and fi - R factors. Proceedings of the National Academy of Sciences of the United States of America 24 4628098
2019 A histone H2A derived antimicrobial peptide, Fi-Histin from the Indian White shrimp, Fenneropenaeus indicus: Molecular and functional characterization. Fish & shellfish immunology 23 31252047
2004 Distinctive polymorphism of chicken B-FI (major histocompatibility complex class I) molecules. Poultry science 23 15109057
1983 Nucleotide sequence of a rabbit IgG heavy chain from the recombinant F-I haplotype. Immunogenetics 22 6313520
2018 Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89. Bioorganic & medicinal chemistry 20 29452840
2012 In utero and early-life exposure of rats to a Wi-Fi signal: screening of immune markers in sera and gestational outcome. Bioelectromagnetics 20 22228576
2002 Tissue distribution of different mercurial compounds analyzed by the improved FI-CVAAS. Journal of analytical toxicology 20 12166816
2017 Systematic Functional Testing of Rare Variants: Contributions of CFI to Age-Related Macular Degeneration. Investigative ophthalmology & visual science 19 28282489
1991 Functional insertion of the SV40 large T oncogene in cystic fibrosis intestinal epithelium. Characterization of CFI-3 cells. The Journal of biological chemistry 19 1718974
1979 Studies on proteinases from Calotropis gigantea latex. II. Physico-chemichal properties of calotropain-FI and FII. Biochimica et biophysica acta 19 444538
2023 OncoTherad® (MRB-CFI-1) Nanoimmunotherapy: A Promising Strategy to Treat Bacillus Calmette-Guérin-Unresponsive Non-Muscle-Invasive Bladder Cancer: Crosstalk among T-Cell CX3CR1, Immune Checkpoints, and the Toll-Like Receptor 4 Signaling Pathway. International journal of molecular sciences 17 38139364
2020 Anticancer effects of the PLK4 inhibitors CFI-400945 and centrinone in Ewing's sarcoma cells. Journal of cancer research and clinical oncology 16 32770382
2017 The effect of Wi-Fi electromagnetic waves in unimodal and multimodal object recognition tasks in male rats. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 16 28332042
2016 Application prospective of nanoprobes with MRI and FI dual-modality imaging on breast cancer stem cells in tumor. Journal of nanobiotechnology 16 27339420
2013 Decrease in formalin-inactivated respiratory syncytial virus (FI-RSV) enhanced disease with RSV G glycoprotein peptide immunization in BALB/c mice. PloS one 16 24376637
2011 Hi-Fi transmission of periodic signals amid cell-to-cell variability. Molecular bioSystems 16 21559542
2013 Secretory expression of thermostable alkaline protease from Bacillus stearothermophilus FI by using native signal peptide and α-factor secretion signal in Pichia pastoris. Genes & genetic systems 15 23832300
1982 Bacteriophage lambda DNA packaging in vitro. The involvement of the lambda FI gene product, single-strand DNA, and a novel lambda-directed protein in the packaging reaction. The Journal of biological chemistry 15 6279661
2023 Preclinical characterization and clinical trial of CFI-400945, a polo-like kinase 4 inhibitor, in patients with relapsed/refractory acute myeloid leukemia and higher-risk myelodysplastic neoplasms. Leukemia 14 38114624
2020 The radio-protective effect of rosmarinic acid against mobile phone and Wi-Fi radiation-induced oxidative stress in the brains of rats. Pharmacological reports : PR 14 32128712
2018 Moderate Dose of Trolox Preventing the Deleterious Effects of Wi-Fi Radiation on Spermatozoa In vitro through Reduction of Oxidative Stress Damage. Chinese medical journal 13 29451144
2017 Early Versus Late Diagnosis of Complement Factor I Deficiency: Clinical Consequences Illustrated in Two Families with Novel Homozygous CFI Mutations. Journal of clinical immunology 13 28942469
2010 The effects of acute dynamic exercise on haemostasis in fi rst class Scottish football referees. British journal of sports medicine 13 19019900
1997 Production of recombinant Der fI with the native IgE-binding activity using a baculovirus expression system. Bioscience, biotechnology, and biochemistry 13 9362114
2017 Effects of electromagnetic waves emitted from 3G+wi-fi modems on human semen analysis. Urologia 12 28967061
2014 CFI-rs7356506 is a genetic protective factor for acute anterior uveitis in Chinese patients. The British journal of ophthalmology 12 25075123
2014 Influence of smartphone Wi-Fi signals on adipose-derived stem cells. The Journal of craniofacial surgery 12 25098574
2010 [Guidelines for the management of nilotinib (Tasigna)-induced side effects in chronic myelogenous leukemia: recommendations of French Intergroup of CML (Fi-LMC group)]. Bulletin du cancer 12 20529767
1971 Isolation and properties of RNA replicases induced by SP and FI phages. Proceedings of the National Academy of Sciences of the United States of America 12 5288764
2015 Novel CFI mutation in a patient with leukocytoclastic vasculitis may redefine the clinical spectrum of Complement Factor I deficiency. Clinical immunology (Orlando, Fla.) 11 25988862
2008 Molecular basis of complement factor I (CFI) polymorphism: one of two polymorphic suballeles responsible for CFI A is Japanese-specific. Journal of human genetics 11 18825487
1994 Expression of the cellulase (FI-CMCase) gene of Aspergillus aculeatus in Saccharomyces cerevisiae. Bioscience, biotechnology, and biochemistry 11 7764982
1975 Amplification of sex repressor function of one fi-+ R-factor during anaerobic growth of Escherichia coli. Journal of bacteriology 11 1095555
2023 Cell context-dependent CFI-1/ARID3 functions control neuronal terminal differentiation. Cell reports 10 36897776
2022 OncoTherad® (MRB-CFI-1) nano-immunotherapy reduced tumoral progression in non-muscle invasive bladder cancer through activation of Toll-like signaling pathway. Tissue & cell 10 35245856
2022 Role of 2.4 GHz radiofrequency radiation emitted from Wi-Fi on some miRNA and faty acids composition in brain. Electromagnetic biology and medicine 10 35435088
2020 FI-Net: Identification of Cancer Driver Genes by Using Functional Impact Prediction Neural Network. Frontiers in genetics 10 33244318
2019 Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration. Disease markers 10 31583032
2019 Evaluation of Wi-Fi Radiation Effects on Antibiotic Susceptibility, Metabolic Activity and Biofilm Formation by Escherichia Coli 0157H7, Staphylococcus Aureus and Staphylococcus Epidermis. Journal of biomedical physics & engineering 10 31750272
1996 Trypanosoma cruzi cytosolic alkaline antigens (FI) induce polyclonal activation in murine normal B cells. Scandinavian journal of immunology 10 8711435
1993 Expression of the cellulase (FI-CMCase) gene of Aspergillus aculeatus in Escherichia coli. Bioscience, biotechnology, and biochemistry 10 7764343
2023 Electrochemical site-selective direct C-H sulfenylation and selenylation of a chromone-fused-indolizine (CFI) skeleton. Chemical communications (Cambridge, England) 9 37066490
2019 [Recommendations from the French CML Study Group (Fi-LMC) for BCR-ABL1 kinase domain mutation analysis in chronic myeloid leukemia]. Bulletin du cancer 9 31353136
2016 Crystal structure and genetic modifications of FI-CMCase from Aspergillus aculeatus F-50. Biochemical and biophysical research communications 9 27470581
1990 An automated microtechnique for selenium determination in human body fluids by flow injection hydride atomic absorption spectrometry (FI-HAAS). Journal of trace elements and electrolytes in health and disease 9 2135957
1988 Partial FI gene-independence of lambda-21 hybrid phages specifying chimeric terminases. Virology 9 2973176
2020 Complement family member CFI polymorphisms and AMD susceptibility from a comprehensive analysis. Bioscience reports 8 32215612
2017 Study of potential health effects of electromagnetic fields of telephony and Wi-Fi, using chicken embryo development as animal model. Bioelectromagnetics 8 28092407
2011 cDNA cloning, characterization and expression analysis of a novel antimicrobial peptide gene penaeidin-3 (Fi-Pen3) from the haemocytes of Indian white shrimp Fenneropenaeus indicus. Microbiological research 8 21885268