Affinage

BRMS1L

Breast cancer metastasis-suppressor 1-like protein · UniProt Q5PSV4

Round 2 corrected
Length
323 aa
Mass
37.6 kDa
Annotated
2026-04-28
130 papers in source corpus 5 papers cited in narrative 5 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BRMS1L is a subunit of the Sin3A–HDAC co-repressor complex that functions as a metastasis suppressor by mediating epigenetic silencing of pro-metastatic target genes (PMID:15451426, PMID:25406648). It recruits HDAC1 to the FZD10 promoter, driving histone H3K9 deacetylation that silences FZD10 transcription and thereby inhibits WNT3–β-catenin signalling and epithelial-mesenchymal transition in breast cancer cells (PMID:25406648). BRMS1L expression is transcriptionally activated by p53 family members (p53, TAp63γ, TAp73β) through conserved intronic and upstream response elements, and is post-transcriptionally repressed by miR-106b, miR-93-5p, and miR-934, linking its anti-metastatic activity to both tumour-suppressor and miRNA regulatory networks (PMID:29030916, PMID:25406648, PMID:29760585, PMID:31298311).

Mechanistic history

Synthesis pass · year-by-year structured walk · 5 steps
  1. 2004 Medium

    Identification of BRMS1L as a stoichiometric component of the mSin3A/HDAC1 co-repressor complex established its molecular context as an HDAC-associated transcriptional co-repressor rather than a stand-alone DNA-binding factor.

    Evidence Biochemical purification and mass spectrometry of endogenous mSin3A complexes, Gal4-tethered repression reporter assay, HeLa cells

    PMID:15451426

    Open questions at the time
    • Single study without reciprocal pull-down from BRMS1L bait
    • Direct chromatin targets of BRMS1L-containing complexes not identified
    • Whether BRMS1L is required for complex integrity or is an accessory subunit is unclear
  2. 2014 High

    Connecting BRMS1L's co-repressor activity to a specific metastasis-relevant pathway resolved how it suppresses breast cancer metastasis: BRMS1L recruits HDAC1 to the FZD10 promoter, deacetylates H3K9, silences FZD10, and thereby blocks Wnt/β-catenin-driven EMT.

    Evidence Co-immunoprecipitation, ChIP for H3K9ac at FZD10 promoter, siRNA knockdown, luciferase reporters, xenograft metastasis model in mice, miR-106b target validation, breast cancer cell lines

    PMID:25406648

    Open questions at the time
    • Genome-wide binding profile of BRMS1L is unknown; FZD10 may not be the sole critical target
    • Whether BRMS1L loss is sufficient for metastasis in immunocompetent models is untested
    • Structural basis for BRMS1L–HDAC1 interaction not determined
  3. 2017 Medium

    Demonstrating that BRMS1L is a direct transcriptional target of p53, TAp63γ, and TAp73β placed it within the p53 tumour-suppressor axis, explaining how upstream tumour-suppressive signals converge on BRMS1L-mediated metastasis inhibition.

    Evidence Microarray screen, luciferase reporter assays with response-element mutations in BRMS1L intron 1 and upstream region, siRNA knockdown invasion/migration assays, cancer cell lines

    PMID:29030916

    Open questions at the time
    • ChIP confirmation of endogenous p53-family occupancy at BRMS1L locus not shown
    • Relative contribution of each p53 family member under physiological conditions is unclear
    • Whether p53-dependent regulation is context-specific (e.g. tissue-type) is not addressed
  4. 2018 Medium

    Validation of miR-93-5p as a second miRNA repressor of BRMS1L in adenoid cystic carcinoma extended the miRNA-BRMS1L-Wnt axis beyond breast cancer, reinforcing BRMS1L as a general gatekeeper of Wnt/β-catenin activation across tumour types.

    Evidence 3′-UTR luciferase reporter, TOP/FOP Wnt reporter, rescue by BRMS1L re-expression, LACC cell lines

    PMID:29760585

    Open questions at the time
    • Single cancer type without in vivo validation
    • Whether miR-93-5p operates through BRMS1L in normal lacrimal tissue is unknown
    • Downstream Wnt target gene specificity not resolved
  5. 2019 Medium

    Identification of miR-934 as a third miRNA targeting BRMS1L in ovarian cancer linked BRMS1L loss to both increased proliferation and reduced apoptosis, broadening its tumour-suppressive functions beyond EMT/metastasis.

    Evidence 3′-UTR luciferase reporter, CCK-8 proliferation, TUNEL apoptosis assay, western blot for Ki67/CyclinD1/Caspase-3, ovarian cancer cell lines

    PMID:31298311

    Open questions at the time
    • Single study in one journal without in vivo confirmation
    • Mechanism by which BRMS1L regulates apoptosis (direct target genes) is not delineated
    • Specificity of miR-934 effect — other targets may contribute to the phenotype

Open questions

Synthesis pass · forward-looking unresolved questions
  • The genome-wide repertoire of BRMS1L-regulated loci, the structural basis of its integration into the Sin3A–HDAC complex, and its physiological role in non-cancer contexts remain unresolved.
  • No genome-wide ChIP-seq or CUT&Tag profiling of BRMS1L
  • No structural or cryo-EM data for BRMS1L within the Sin3A complex
  • No genetic mouse model (knockout or conditional) characterising BRMS1L loss in vivo

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 2
Localization
GO:0005634 nucleus 1
Pathway
R-HSA-162582 Signal Transduction 2 R-HSA-4839726 Chromatin organization 2 R-HSA-74160 Gene expression (Transcription) 2
Partners
HDAC1ING1SIN3A
Complex memberships
Sin3A-HDAC co-repressor complex

Evidence

Reading pass · 5 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 BRMS1L (referred to as 'p40') was identified as a novel component of the mSin3A/p33(ING1b)/HDAC1 histone deacetylase co-repressor complex by biochemical purification and mass spectrometry. The p40-associated complex showed strong HDAC activity, and when tethered to a Gal4 DNA-binding domain, Gal-p40 significantly repressed transcription of a Gal-luciferase reporter. BRMS1L bears homology to yeast Sds3 and mammalian mSds3, and overexpression inhibited cell growth. Biochemical purification, mass spectrometry, HDAC activity assay, Gal4-tethered transcriptional repression assay Biochemical and biophysical research communications Medium 15451426
2014 BRMS1L is a component of the Sin3A-HDAC co-repressor complex that suppresses breast cancer metastasis by epigenetically silencing FZD10 (a Wnt receptor) through HDAC1 recruitment and histone H3K9 deacetylation at the FZD10 promoter. This silencing inhibits aberrant WNT3-FZD10-β-catenin signalling and epithelial-mesenchymal transition. BRMS1L was also identified as a direct target of miR-106b, whose upregulation reduces BRMS1L levels in breast cancer cells. Co-immunoprecipitation, ChIP assay (H3K9 acetylation), luciferase reporter assay, siRNA knockdown, xenograft mouse model, miRNA target validation Nature communications High 25406648
2017 BRMS1L is a transcriptional target of p53 family proteins (p53, TAp63γ, TAp73β). Two p53 family response elements were identified in the first intron and upstream region of BRMS1L, conserved among mammals. Ectopic expression of BRMS1L inhibited cancer cell invasion and migration, while siRNA knockdown of BRMS1L induced the opposite effect, placing BRMS1L downstream of the p53 pathway in regulating cell invasion. Microarray analysis, luciferase reporter assay with response element mutations, siRNA knockdown, invasion/migration assays Cancer science Medium 29030916
2018 miR-93-5p promotes lacrimal gland adenoid cystic carcinoma (LACC) cell migration, invasion, and proliferation by directly targeting and suppressing BRMS1L expression. Luciferase reporter assays confirmed miR-93-5p binding to the BRMS1L 3'-UTR. BRMS1L overexpression inhibited EMT markers and suppressed Wnt signaling (reduced TOP/FOP luciferase activity), while miR-93-5p overexpression activated Wnt signaling in a BRMS1L-dependent manner. Luciferase reporter assay (3'-UTR targeting), western blotting, qRT-PCR, wound healing/transwell assays, TOP/FOP Wnt reporter assay Cancer cell international Medium 29760585
2019 miR-934 promotes ovarian cancer cell proliferation and inhibits apoptosis by targeting BRMS1L. Luciferase reporter assays confirmed direct miR-934 binding to BRMS1L mRNA. miR-934 inhibition increased BRMS1L expression, reduced Ki67 and Cyclin D1, and induced Caspase-3 activation, demonstrating BRMS1L's role in regulating the apoptosis/proliferation balance downstream of miR-934. Luciferase reporter assay, CCK-8 proliferation assay, TUNEL apoptosis assay, western blotting, qRT-PCR European review for medical and pharmacological sciences Medium 31298311

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2004 Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. The Journal of experimental medicine 718 14707118
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2006 ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Molecular cell 550 16387653
1996 The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. The Journal of experimental medicine 544 8551218
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
1995 Regulation of interleukin 12 p40 expression through an NF-kappa B half-site. Molecular and cellular biology 413 7565674
1995 Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blood 308 7605994
2003 Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. The Journal of clinical investigation 286 12952918
1993 The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. European journal of immunology 275 8103745
1998 SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Molecular cell 250 9651585
2000 Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Proceedings of the National Academy of Sciences of the United States of America 240 11058167
2013 The functional interactome landscape of the human histone deacetylase family. Molecular systems biology 235 23752268
2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Genomics 222 17207965
2016 A High-Density Map for Navigating the Human Polycomb Complexome. Cell reports 216 27705803
2018 An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. Nature communications 201 29568061
1997 In vivo production and function of IL-12 p40 homodimers. Journal of immunology (Baltimore, Md. : 1950) 184 9127002
2019 H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. Nature cell biology 162 30804502
2020 A High-Density Human Mitochondrial Proximity Interaction Network. Cell metabolism 148 32877691
2002 Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. Experimental cell research 124 11822878
2022 Human transcription factor protein interaction networks. Nature communications 123 35140242
2015 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Molecular systems biology 120 25609649
1999 Amplification and overexpression of p40 subunit of eukaryotic translation initiation factor 3 in breast and prostate cancer. The American journal of pathology 118 10362802
2002 The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase. The EMBO journal 117 12456638
2019 Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Genes & development 110 31753913
2018 The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. eLife 102 29911972
2022 EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation. Nature communications 99 35013218
1991 Sequences required for coordinate induction of adeno-associated virus p19 and p40 promoters by Rep protein. Journal of virology 99 2033660
2020 N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1. EBioMedicine 95 32853985
2014 BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10. Nature communications 92 25406648
2003 Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages. Journal of neurochemistry 92 12871593
2006 Suppression of human ovarian carcinoma metastasis by the metastasis-suppressor gene, BRMS1. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 88 16681721
2002 IL-12: the role of p40 versus p75. Scandinavian journal of immunology 86 12100467
2000 Analysis of mechanisms underlying BRMS1 suppression of metastasis. Clinical & experimental metastasis 86 11827072
2010 Functional analysis of the p40 and p75 proteins from Lactobacillus casei BL23. Journal of molecular microbiology and biotechnology 85 21178363
2004 Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway. Molecular and cellular biology 82 14993278
2014 Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation. Cell reports 80 24981860
1998 cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Gene 80 9714768
2020 Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Cell reports 79 32814053
2011 Phosphorylation of RelA/p65 promotes DNMT-1 recruitment to chromatin and represses transcription of the tumor metastasis suppressor gene BRMS1. Oncogene 79 21765477
2012 Interaction of two translational components, lysyl-tRNA synthetase and p40/37LRP, in plasma membrane promotes laminin-dependent cell migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 75 22751010
2008 Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis and correlates with improved patient survival in non-small cell lung cancer. Cancer letters 72 19111386
1994 Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ. European journal of immunology 72 7925572
2003 Exhaustive exercise and type-1/type-2 cytokine balance with special focus on interleukin-12 p40/p70. Exercise immunology review 65 14686094
2016 Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. Molecular & cellular proteomics : MCP 64 27634302
2023 Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein-protein interactions in the human cell. Proceedings of the National Academy of Sciences of the United States of America 60 37071682
2019 Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Nature communications 60 31515488
2018 The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation. Cancer research 60 29844126
1996 Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes. European journal of immunology 60 8647196
2006 Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone. Biochemical and biophysical research communications 59 16919237
2004 Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. Biochemical and biophysical research communications 59 15451426
2020 Lactobacillus casei extracellular vesicles stimulate EGFR pathway likely due to the presence of proteins P40 and P75 bound to their surface. Scientific reports 57 33159116
2014 The utility of a novel triple marker (combination of TTF1, napsin A, and p40) in the subclassification of non-small cell lung cancer. Human pathology 55 24746197
2012 p40: a p63 isoform useful for lung cancer diagnosis - a review of the physiological and pathological role of p63. Acta cytologica 51 23221041
2010 Anti-p40 antibodies ustekinumab and briakinumab: blockade of interleukin-12 and interleukin-23 in the treatment of psoriasis. Seminars in cutaneous medicine and surgery 51 20430307
2014 p40 is the best marker for diagnosing pulmonary squamous cell carcinoma: comparison with p63, cytokeratin 5/6, desmocollin-3, and sox2. Applied immunohistochemistry & molecular morphology : AIMM 50 24805133
2008 Epigenetic silencing contributes to the loss of BRMS1 expression in breast cancer. Clinical & experimental metastasis 50 18566899
2011 Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex. Biochemical and biophysical research communications 49 22085717
2012 Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex. Molecular & cellular proteomics : MCP 47 22984288
2010 Cell cycle regulator ING4 is a suppressor of melanoma angiogenesis that is regulated by the metastasis suppressor BRMS1. Cancer research 46 21056991
2004 Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages. The Journal of biological chemistry 46 14976188
2015 IL12B (p40) Gene Polymorphisms Contribute to Ustekinumab Response Prediction in Psoriasis. Dermatology (Basel, Switzerland) 44 26678060
2008 IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages. Molecular immunology 44 19100623
2017 Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages. Proceedings of the National Academy of Sciences of the United States of America 43 28808017
2004 Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells. Clinical & experimental metastasis 43 15168732
1995 Two markers, IS901-IS902 and p40, identified by PCR and by using monoclonal antibodies in Mycobacterium avium strains. Journal of clinical microbiology 43 7615703
1998 LBP-p40 binds DNA tightly through associations with histones H2A, H2B, and H4. Biochemical and biophysical research communications 42 9878528
2017 Selective neutralization of IL-12 p40 monomer induces death in prostate cancer cells via IL-12-IFN-γ. Proceedings of the National Academy of Sciences of the United States of America 41 29073075
2008 Interleukin-12 p40 gene (IL12B) polymorphisms and the risk of cervical cancer in Korean women. European journal of obstetrics, gynecology, and reproductive biology 40 18367309
2018 p40 Immunohistochemistry Is an Excellent Marker in Primary Lung Squamous Cell Carcinoma. Journal of pathology and translational medicine 39 30235512
2004 The L1 retroelement-related p40 protein induces p38delta MAP kinase. Autoimmunity 39 15115313
1997 p40 molecule regulates NK cell activation mediated by NK receptors for HLA class I antigens and TCR-mediated triggering of T lymphocytes. International immunology 38 9310830
2020 High Prevalence and Disease Correlation of Autoantibodies Against p40 Encoded by Long Interspersed Nuclear Elements in Systemic Lupus Erythematosus. Arthritis & rheumatology (Hoboken, N.J.) 37 31342656
2011 Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding. The Journal of biological chemistry 37 21956105
1996 Analysis of nuclear localization of laminin binding protein precursor p40 (LBP/p40). Biochemical and biophysical research communications 37 8954992
2010 BRMS1 transcriptional repression correlates with CpG island methylation and advanced pathological stage in non-small cell lung cancer. The Journal of pathology 36 20455258
2007 Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1. Journal of proteome research 36 17854218
2002 Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1). International journal of cancer 36 11774238
2015 Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression. Biochemical and biophysical research communications 35 26182878
2011 Unraveling the enigmatic complexities of BRMS1-mediated metastasis suppression. FEBS letters 35 21827753
2019 Agreement of CK5/6, p40, and p63 immunoreactivity in non-small cell lung cancer. Pathology 34 30798982
2014 Loss of BRMS1 promotes a mesenchymal phenotype through NF-κB-dependent regulation of Twist1. Molecular and cellular biology 34 25368381
2008 Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. Journal of immunology (Baltimore, Md. : 1950) 34 18832714
2018 MicroRNA-125a-5p inhibits invasion and metastasis of gastric cancer cells by targeting BRMS1 expression. Oncology letters 33 29552146
2008 BRMS1 suppresses breast cancer metastasis in multiple experimental models of metastasis by reducing solitary cell survival and inhibiting growth initiation. Clinical & experimental metastasis 33 18543067
2014 p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma. Journal of cutaneous pathology 32 25263848
2016 CK2α' Drives Lung Cancer Metastasis by Targeting BRMS1 Nuclear Export and Degradation. Cancer research 30 26980766
2014 Expression of the p40 isoform of p63 has high specificity for cutaneous sarcomatoid squamous cell carcinoma. Journal of cutaneous pathology 30 25263756
2008 Multiple forms of BRMS1 are differentially expressed in the MCF10 isogenic breast cancer progression model. Clinical & experimental metastasis 29 18841483
1996 Identification of the active gene coding for the metastasis-associated 37LRP/p40 multifunctional protein. DNA and cell biology 29 8985115
2016 miR-346 promotes migration and invasion of nasopharyngeal carcinoma cells via targeting BRMS1. Journal of biochemical and molecular toxicology 28 27501413
2006 Identification and immuno-electron microscopy localization of p40, a protein component of immunosuppressive virus-like particles from Leptopilina heterotoma, a virulent parasitoid wasp of Drosophila. The Journal of general virology 28 16432035
2005 Expression of the breast cancer metastasis suppressor gene, BRMS1, in human breast carcinoma: lack of correlation with metastasis to axillary lymph nodes. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 28 16006775
2018 miR-93-5p enhance lacrimal gland adenoid cystic carcinoma cell tumorigenesis by targeting BRMS1L. Cancer cell international 27 29760585
1998 The induction of apoptosis in HeLa cells by the loss of LBP-p40. Cell death and differentiation 27 10200442
2018 BRMS1 coordinates with LSD1 and suppresses breast cancer cell metastasis. American journal of cancer research 25 30416854
2017 MicroRNA-423 enhances the invasiveness of hepatocellular carcinoma via regulation of BRMS1. American journal of translational research 25 29312509
2007 RIP2 mediates LPS-induced p38 and IkappaBalpha signaling including IL-12 p40 expression in human monocyte-derived dendritic cells. European journal of immunology 23 17578844
2014 BRMS1 suppresses glioma progression by regulating invasion, migration and adhesion of glioma cells. PloS one 22 24879377
2018 MicroRNA-3200-5p Promotes Osteosarcoma Cell Invasion via Suppression of BRMS1. Molecules and cells 21 29890825
2015 Down-regulation of BRMS1 by DNA hypermethylation and its association with metastatic progression in triple-negative breast cancer. International journal of clinical and experimental pathology 21 26617826
2014 The utility of p63, p40, and GATA-binding protein 3 immunohistochemistry in diagnosing micropapillary urothelial carcinoma. Human pathology 21 24993315
2015 Breast carcinoma metastasis suppressor gene 1 (BRMS1): update on its role as the suppressor of cancer metastases. Cancer metastasis reviews 19 26328523
2012 Metastasis suppression by BRMS1 associated with SIN3 chromatin remodeling complexes. Cancer metastasis reviews 19 22678236
2012 Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40. Veterinary parasitology 19 23021260
2009 Identification of essential sequences for cellular localization in BRMS1 metastasis suppressor. PloS one 19 19649328
1992 Nonintegrin laminin receptors in the nervous system: evidence for lack of a relationship to P40. Journal of neurobiology 19 1279113
2019 ∆Np63/p40 correlates with the location and phenotype of basal/mesenchymal cancer stem-like cells in human ER+ and HER2+ breast cancers. The journal of pathology. Clinical research 18 31591823
2008 Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells. Cancer letters 18 19070953
2022 A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos. Science translational medicine 17 36197962
2015 Breast cancer metastasis suppressor 1 (BRMS1) attenuates TGF-β1-induced breast cancer cell aggressiveness through downregulating HIF-1α expression. BMC cancer 17 26520789
2013 The C-terminal putative nuclear localization sequence of breast cancer metastasis suppressor 1, BRMS1, is necessary for metastasis suppression. PloS one 17 23390556
2013 Comparison of p40 (ΔNp63) and p63 expression in prostate tissues--which one is the superior diagnostic marker for basal cells? Histopathology 17 23668398
2013 Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix. Molecular carcinogenesis 17 24000122
2021 Coexpression of ΔNp63/p40 and TTF1 Within Most of the Same Individual Cells Identifies Life-Threatening NSCLC Featuring Squamous and Glandular Biphenotypic Differentiation: Clinicopathologic Correlations. JTO clinical and research reports 16 34746884
2017 Identification and characterization of a metastatic suppressor BRMS1L as a target gene of p53. Cancer science 16 29030916
2015 Cholesterol Modification of p40-Specific Small Interfering RNA Enables Therapeutic Targeting of Dendritic Cells. Journal of immunology (Baltimore, Md. : 1950) 16 26232431
2000 Protein disulfide isomerase-mediated cell-free assembly of recombinant interleukin-12 p40 homodimers. European journal of biochemistry 16 11054122
2021 Diagnostic utility of p63/p40 in the histologic differentiation of salivary gland tumors: A systematic review. Oral surgery, oral medicine, oral pathology and oral radiology 15 34518135
2019 Oncogene miR-934 promotes ovarian cancer cell proliferation and inhibits cell apoptosis through targeting BRMS1L. European review for medical and pharmacological sciences 15 31298311
2015 BRMS1 regulates apoptosis in non-small cell lung cancer cells. Cell biochemistry and biophysics 15 25182004
2009 Vaccination of melanoma patients with Melan-A/Mart-1 peptide and Klebsiella outer membrane protein p40 as an adjuvant. Journal of immunotherapy (Hagerstown, Md. : 1997) 15 19752746
2014 p40 (ΔNp63) expression in breast disease and its correlation with p63 immunohistochemistry. International journal of clinical and experimental pathology 14 24696720