Affinage

ALDOC

Fructose-bisphosphate aldolase C · UniProt P09972

Round 2 corrected
Length
364 aa
Mass
39.5 kDa
Annotated
2026-04-28
46 papers in source corpus 31 papers cited in narrative 26 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ALDOC (fructose-bisphosphate aldolase C) is the brain-enriched isozyme of the glycolytic enzyme aldolase, catalyzing fructose-1,6-bisphosphate cleavage and serving as a canonical marker of cerebellar Purkinje cell stripe identity and astrocyte populations throughout the brain (PMID:5230152, PMID:24475166, PMID:41339882). Beyond its metabolic role, ALDOC functions as a signaling scaffold: it disassembles the β-catenin destruction complex to activate Wnt signaling when released from EPB41 sequestration, interacts with HIF-1α to co-activate glycolytic gene transcription (e.g., PGK1), stabilizes AMPK signaling through interaction with MUC16c, and activates AKT-mTORC1 signaling to promote lipid accumulation (PMID:33242559, PMID:40518543, PMID:32502493, PMID:39428631). ALDOC-driven aerobic glycolysis supports tumor spheroid survival and chemoresistance across lung, breast, colorectal, and glioblastoma cancers, where its expression is regulated by NME1 promoter binding, HIF-1α/BMAL1 hypoxic cascades, and promoter methylation (PMID:36945054, PMID:30396920, PMID:40535800, PMID:38741139). ALDOC also physically interacts with Huntingtin, and its Drosophila ortholog genetically modifies polyglutamine-induced neurodegeneration (PMID:17500595).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1966 High

    Establishing that aldolase exists as tissue-specific isozymes resolved the question of how a ubiquitous glycolytic step could be differentially regulated in brain versus muscle and liver.

    Evidence Biochemical fractionation and enzymatic characterization of mammalian tissue extracts

    PMID:5230152

    Open questions at the time
    • Catalytic kinetic differences between isozymes not fully resolved
    • No structural basis for isozyme-specific properties
  2. 2007 High

    Discovery of ALDOC as a direct Huntingtin-interacting protein validated across species linked a glycolytic enzyme to neurodegenerative disease mechanisms, raising the question of whether ALDOC has non-metabolic neuronal functions.

    Evidence Yeast two-hybrid, AP-MS, co-IP from mouse brain, and Drosophila genetic modifier assay for polyglutamine toxicity

    PMID:17500595

    Open questions at the time
    • Mechanism by which ALDOC modifies polyglutamine toxicity unknown
    • Whether the interaction is enzymatic-activity-dependent not tested
  3. 2010 Medium

    Identification of ALDOC as a substrate of Cullin-RING ubiquitin ligases and mapping of specific ubiquitylation sites revealed that ALDOC protein levels are regulated by the ubiquitin-proteasome system, though functional consequences remained uncharacterized.

    Evidence Quantitative proteomics (GPS/QUAINT) upon Cullin inactivation; diglycine-modified peptide enrichment and mass spectrometry

    PMID:21139048 PMID:21145461

    Open questions at the time
    • Specific E3 ligase(s) targeting ALDOC not identified
    • How ubiquitylation affects ALDOC catalytic activity or localization unknown
  4. 2012 Medium

    Detection of ALDOC as an mRNA-binding protein by interactome capture revealed an unexpected moonlighting function beyond glycolysis, opening the question of what RNAs it binds and to what effect.

    Evidence UV crosslinking and oligo(dT) pulldown followed by mass spectrometry in HeLa cells

    PMID:22658674

    Open questions at the time
    • Target mRNAs not identified
    • Functional consequence of RNA binding not determined
    • Whether RNA binding and enzymatic activity are mutually exclusive unknown
  5. 2014 High

    Aldoc-Venus knock-in mice demonstrated that ALDOC (zebrin II) defines functionally distinct Purkinje cell subpopulations whose axons project to specific cerebellar nuclear targets, establishing ALDOC stripe expression as a marker of cerebellar circuit organization.

    Evidence Knock-in mouse model with fluorescence imaging, climbing fiber projection mapping, and co-staining

    PMID:24475166

    Open questions at the time
    • Whether ALDOC enzymatic activity itself contributes to Purkinje cell stripe identity versus being a passive marker
    • Upstream regulators of stripe-specific ALDOC expression not fully resolved
  6. 2018 High

    Demonstration that NME1 directly binds the ALDOC promoter and recruits RNA Pol II with activating histone marks provided the first defined transcription factor–promoter mechanism controlling ALDOC expression, relevant to melanoma metastasis suppression.

    Evidence ChIP for NME1/H3K4me3/H3K27ac/RNA Pol II, luciferase reporter, pre-mRNA qPCR in melanoma cells

    PMID:30396920

    Open questions at the time
    • Whether NME1-ALDOC regulation operates in brain tissues unknown
    • Downstream effectors of NME1-driven ALDOC in metastasis not characterized
  7. 2020 Medium

    Two studies established ALDOC as a signaling scaffold in cancer: MUC16c interaction stabilizes ALDOC and activates AMPK in gallbladder carcinoma, while EPB41 loss releases ALDOC to disassemble the β-catenin destruction complex and activate Wnt signaling in NSCLC.

    Evidence Co-IP/MS, siRNA knockdown, glycolysis assays in gallbladder carcinoma; co-IP, siRNA, β-catenin immunofluorescence, xenografts in NSCLC

    PMID:32502493 PMID:33242559

    Open questions at the time
    • Structural basis for ALDOC interaction with the destruction complex unknown
    • Whether ALDOC enzymatic activity is required for destruction complex disassembly not tested
    • MUC16c–ALDOC interaction confirmed in single cancer type only
  8. 2023 Medium

    Functional siRNA experiments across lung and breast cancer 3D spheroids demonstrated that ALDOC catalytic activity is rate-limiting for anchorage-independent lactate production and tumor cell survival, directly linking its glycolytic function to cancer phenotypes.

    Evidence siRNA knockdown, 3D spheroid culture, metabolomics, transcriptomics, and proteomics in lung and breast cancer lines

    PMID:36945054

    Open questions at the time
    • No catalytic-dead mutant used to separate enzymatic from scaffolding roles
    • In vivo tumor growth effects not shown
  9. 2024 Medium

    ALDOC was placed upstream of AKT-mTORC1 in lipid accumulation and shown to interact with HIF-1α to co-activate glycolytic gene PGK1 transcription, expanding its non-enzymatic signaling roles to metabolic reprogramming beyond cancer.

    Evidence ALDOC overexpression with rapamycin rescue in myotubes/pig model; co-IP, ChIP, dual-luciferase in CRC cells with xenografts

    PMID:39428631 PMID:40518543

    Open questions at the time
    • How ALDOC activates AKT mechanistically is unclear
    • Whether ALDOC–HIF-1α interaction is direct or bridged not resolved
    • Single-lab studies for both findings
  10. 2025 High

    BAC-GFP transgenic mice validated ALDOC as a pan-brain astrocyte marker with electrophysiological confirmation, and hypoxic CRC studies linked HIF-1α/BMAL1 transcriptional control of ALDOC to chemoresistance.

    Evidence BAC transgenic mouse with whole-cell patch-clamp; Western blot/qPCR/flow cytometry in CoCl2-treated CRC cells with clinical sample correlation

    PMID:40535800 PMID:41339882

    Open questions at the time
    • Functional consequence of ALDOC loss specifically in astrocytes not tested with conditional knockout
    • BMAL1-ALDOC regulation not confirmed outside CRC

Open questions

Synthesis pass · forward-looking unresolved questions
  • A central unresolved question is whether ALDOC's enzymatic (glycolytic) and non-enzymatic (scaffolding/signaling) functions are separable — no catalytic-dead mutant has been used to dissect these roles, and the structural basis for its interaction with the β-catenin destruction complex, HIF-1α, and Huntingtin remains undefined.
  • No crystal structure of ALDOC in complex with any signaling partner
  • Catalytic-dead separation of enzymatic versus moonlighting functions not performed
  • No conditional knockout in brain to test astrocyte or Purkinje cell functional dependence on ALDOC

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 3 GO:0016829 lyase activity 2 GO:0003723 RNA binding 1 GO:0140110 transcription regulator activity 1
Localization
GO:0005829 cytosol 3 GO:0031410 cytoplasmic vesicle 2 GO:0005634 nucleus 1
Pathway
R-HSA-1643685 Disease 5 R-HSA-162582 Signal Transduction 4 R-HSA-1430728 Metabolism 3
Partners
BMAL1EPB41HIF1AHTTMAPTMUC16NME1UBE2N

Evidence

Reading pass · 26 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1966 Aldolase C (fructose-1,6-bisphosphate aldolase, brain isozyme) was identified as one of multiple distinct forms of fructose diphosphate aldolase in mammalian tissues, establishing it as a tissue-specific glycolytic enzyme isozyme. Biochemical fractionation and enzymatic characterization of mammalian tissue extracts Proceedings of the National Academy of Sciences of the United States of America High 5230152
2006 ALDOC was identified as a lysine-acetylated protein in mammalian cells, including mitochondrial fractions, revealing post-translational acetylation as a regulatory modification on this glycolytic enzyme. Proteomic survey using anti-acetyllysine immunoprecipitation followed by mass spectrometry in HeLa cells and mouse liver mitochondria Molecular cell Medium 16916647
2007 ALDOC was identified as a high-confidence Huntingtin (Htt)-interacting protein by both yeast two-hybrid screening and affinity pull-down/mass spectrometry, and its Drosophila ortholog was validated as a genetic modifier of polyglutamine-induced neurodegeneration. Yeast two-hybrid screening, affinity pull-down with mass spectrometry, co-immunoprecipitation from mouse brain, and Drosophila genetic modifier assay PLoS genetics High 17500595
2008 ALDOC protein was detected in normal human urinary exosomes, indicating it is present in membrane vesicles secreted from renal epithelial cells. LC-MS/MS proteomic profiling of purified urinary exosomes Journal of the American Society of Nephrology : JASN Low 19056867
2010 ALDOC was identified as a substrate of Cullin-RING ubiquitin ligases (CRLs), with its stability regulated by CRL activity, placing it in the ubiquitin-proteasome pathway. Quantitative proteomics (GPS and QUAINT assays) upon genetic and pharmacologic Cullin inactivation Cell Medium 21145461 21963094
2010 ALDOC was identified as a ubiquitylated protein with specific diglycine-modified lysine residues mapped by mass spectrometry, confirming it as an endogenous ubiquitin substrate. Immunoenrichment of diglycine-modified peptides followed by high-resolution mass spectrometry (LTQ Orbitrap Velos) Molecular & cellular proteomics : MCP Medium 21139048 21890473
2010 ALDOC was detected as a component of MHC class II-associated protein complexes in B-cell-derived exosomes, suggesting a role in exosome biology. Quantitative mass spectrometry of co-immunoprecipitated proteins from purified B-cell exosomes Immunology and cell biology Low 20458337
2011 ALDOC was identified as an mRNA-binding protein in HeLa cells by interactome capture, establishing an unexpected RNA-binding function for this glycolytic enzyme. UV crosslinking of mRNA-protein complexes followed by oligo(dT) pulldown and mass spectrometry (interactome capture) Cell Medium 22658674
2012 ALDOC was identified as a component of stable soluble human protein complexes by chromatographic co-fractionation and quantitative mass spectrometry. Biochemical fractionation of human cell extracts into >1,000 fractions combined with quantitative tandem mass spectrometry Cell Medium 22939629
2012 ALDOC co-eluted with defined protein complexes in size-exclusion chromatography interactome mapping, providing stoichiometric information about its complex membership. Size-exclusion chromatography combined with quantitative SILAC proteomics Nature methods Low 22863883
2014 ALDOC (zebrin II) is expressed heterogeneously in Purkinje cell subpopulations arranged in longitudinal stripes in the cerebellar cortex and marks distinct neuronal populations including cartwheel cells, inner ear sensory epithelium, and retinal cells; Aldoc-Venus knock-in mice revealed that ALDOC-positive PC axons project specifically to caudoventral cerebellar nuclei, demonstrating a functional anatomical organization linked to ALDOC expression. Aldoc-Venus knock-in mouse generation; fluorescence imaging, serial section alignment, climbing fiber projection analysis, co-staining with HSP25 PloS one High 24475166
2015 ALDOC was identified as a protein with binary protein-protein interactions in the human interactome (HuRI/BioPlex), placing it within a network of cellular protein complexes in HEK293T cells. High-throughput affinity purification mass spectrometry (AP-MS) of 2,594–10,128 human proteins Cell / Nature Low 26186194 28514442 32296183 33961781
2015 Disease-associated missense mutations in ALDOC perturb protein-protein interactions (edgetic effects), demonstrating that specific alleles disrupt a subset of ALDOC's interactions rather than globally destabilizing the protein. Systematic interaction assays (Y2H and co-immunoprecipitation) of thousands of disease-associated alleles Cell Medium 25910212
2017 Proteome-wide cross-linking mass spectrometry identified structural contacts of ALDOC within macromolecular assemblies in HeLa cell lysates, providing information on its interaction interfaces. Chemical cross-linking followed by MS2/MS3 hybrid data acquisition and XlinkX v2.0 analysis Nature communications Low 28524877
2018 NME1 (metastasis suppressor) directly binds the ALDOC promoter and activates ALDOC transcription by recruiting RNA polymerase II and promoting activating epigenetic marks (H3K4me3 and H3K27ac) at the ALDOC locus in melanoma cells. qRT-PCR (pre-mRNA measurement), promoter-luciferase reporter assay, chromatin immunoprecipitation (ChIP) for NME1, H3K4me3, H3K27ac, and RNA Pol II Anticancer research High 30396920
2020 MUC16 C-terminal domain (MUC16c) physically interacts with ALDOC, promotes ALDOC protein stability, and disrupts ALDOC's ability to sense glucose deficiency, thereby activating the AMPK pathway and promoting gallbladder carcinoma cell proliferation and glycolysis. Mass spectrometry of co-immunoprecipitated proteins, immunoblotting, siRNA knockdown of ALDOC, glucose uptake and glycolysis assays, IHC Experimental cell research Medium 32502493
2020 EPB41 forms a complex with ALDOC, sequestering it; loss of EPB41 releases free ALDOC, which disassembles the β-catenin destruction complex (containing GSK3β), leading to β-catenin nuclear translocation and Wnt pathway activation in NSCLC. Thus ALDOC functions as a negative regulator of the β-catenin destruction complex. Co-immunoprecipitation, siRNA knockdown, in vitro and in vivo NSCLC models, immunofluorescence for β-catenin localization Cancer letters Medium 33242559
2022 ALDOC was identified as a component of the Tau (MAPT) interactome in human iPSC-derived neurons; its interaction with Tau was detected by APEX proximity labeling and AP-MS. Engineered APEX proximity labeling combined with quantitative AP-MS and proximity ligation assay (PLA) Cell Medium 35063084
2022 OpenCell systematic endogenous tagging revealed ALDOC localization within human cells and its protein interaction partners at endogenous expression levels. CRISPR-based endogenous GFP tagging, confocal live-cell imaging, affinity purification mass spectrometry Science (New York, N.Y.) Low 35271311
2023 ALDOC glycolytic activity supports anchorage-independent 3D tumor spheroid survival and growth; siRNA-mediated knockdown of ALDOC significantly reduced lactate production, cell viability, and spheroid size in lung and breast cancer cell lines, demonstrating ALDOC drives glucose metabolism toward enhanced lactate production in these contexts. siRNA knockdown, 3D spheroid culture, metabolomics (lactate/glucose/fructose measurement), transcriptomics, proteomics Journal of experimental & clinical cancer research : CR Medium 36945054
2023 ALDOC promotes NSCLC by enhancing MYC-mediated transcription of UBE2N (ubiquitin-conjugating enzyme E2N), and this ALDOC/UBE2N axis activates the Wnt/β-catenin pathway; knockdown of UBE2N or Wnt inhibition reversed ALDOC-driven NSCLC progression. siRNA knockdown, Wnt pathway inhibitor treatment, in vitro and in vivo (xenograft) models, gene expression analysis Aging Medium 37724906
2024 ALDOC loss in GBM promotes tumor cell invasion and migration; hypermethylation-driven loss of ALDOC expression is associated with serotonin hypersecretion and inhibition of PPAR-γ signaling. ALDOC regulates serotonin levels and protects PPAR-γ from serotonin-mediated degradation; PPAR-γ agonists restore this axis and enhance temozolomide efficacy in orthotopic GBM models. Methylation sequencing, omics datasets, cell and mouse orthotopic GBM models, PPAR-γ agonist treatment, survival analysis Cell communication and signaling : CCS Medium 38741139
2024 ALDOC overexpression activates the AKT-mTORC1 signaling axis to promote lipid accumulation in myotubes and intramuscular adipocytes; the mTORC1 inhibitor rapamycin abrogated this proadipogenic effect, placing ALDOC upstream of AKT-mTORC1 in fat deposition. Transcriptome sequencing, ALDOC overexpression in vitro and in vivo (pig model), rapamycin inhibition, lipid accumulation assays Journal of agricultural and food chemistry Medium 39428631
2025 HIF-1α upregulates BMAL1, which in turn increases ALDOC expression in hypoxic colorectal cancer cells; this HIF-1α/BMAL1/ALDOC cascade promotes glycolytic activity and reduces apoptosis, thereby decreasing sensitivity to oxaliplatin. Western blotting, qPCR, CCK-8 cell viability, flow cytometry apoptosis, lactate/ATP measurement in CRC cells under CoCl2-induced hypoxia; clinical sample correlation Journal of Cancer Medium 40535800
2025 ALDOC interacts with HIF1A (HIF-1α) and enhances its transcriptional activity on the PGK1 promoter in colorectal cancer cells; dual-luciferase reporter assays and ChIP confirmed ALDOC-mediated transcriptional activation of PGK1, promoting aerobic glycolysis and CRC progression. Co-immunoprecipitation, dual-luciferase reporter assay, chromatin immunoprecipitation (ChIP), siRNA knockdown, xenograft in vivo models Molecular medicine (Cambridge, Mass.) Medium 40518543
2025 AldoC (ALDOC) is abundantly expressed in astrocytes throughout diverse brain regions; AldoC BAC-GFP transgenic mice confirmed astrocyte identity of GFP-expressing cells, and GFP-positive astrocytes displayed characteristic linear passive conductance of mature astrocytes, validating ALDOC as an astrocyte marker with functional electrophysiological correlate. BAC transgenic mouse generation, confocal immunofluorescence co-labeling, whole-cell patch-clamp electrophysiology of brain slices Molecular brain High 41339882

Source papers

Stage 0 corpus · 46 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 1718 22658674
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2011 Systematic and quantitative assessment of the ubiquitin-modified proteome. Molecular cell 1334 21906983
2006 Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Molecular cell 1260 16916647
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2011 A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Molecular & cellular proteomics : MCP 749 21890473
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2008 Large-scale proteomics and phosphoproteomics of urinary exosomes. Journal of the American Society of Nephrology : JASN 607 19056867
2015 Widespread macromolecular interaction perturbations in human genetic disorders. Cell 454 25910212
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
1966 Multiple forms of fructose diphosphate aldolase in mammalian tissues. Proceedings of the National Academy of Sciences of the United States of America 378 5230152
2011 Global identification of modular cullin-RING ligase substrates. Cell 354 21963094
2007 Huntingtin interacting proteins are genetic modifiers of neurodegeneration. PLoS genetics 325 17500595
2010 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell 318 21145461
2012 A high-throughput approach for measuring temporal changes in the interactome. Nature methods 273 22863883
2010 Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Molecular & cellular proteomics : MCP 262 21139048
2022 Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell 256 35063084
2012 Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Nature cell biology 243 23000965
2017 Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification. Nature communications 221 28524877
2010 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunology and cell biology 221 20458337
2011 Toward an understanding of the protein interaction network of the human liver. Molecular systems biology 207 21988832
2014 Detailed expression pattern of aldolase C (Aldoc) in the cerebellum, retina and other areas of the CNS studied in Aldoc-Venus knock-in mice. PloS one 81 24475166
2023 ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis. Journal of experimental & clinical cancer research : CR 42 36945054
2020 MUC16 C-terminal binding with ALDOC disrupts the ability of ALDOC to sense glucose and promotes gallbladder carcinoma growth. Experimental cell research 27 32502493
2020 EPB41 suppresses the Wnt/β-catenin signaling in non-small cell lung cancer by sponging ALDOC. Cancer letters 26 33242559
2023 ALDOC promotes non-small cell lung cancer through affecting MYC-mediated UBE2N transcription and regulating Wnt/β-catenin pathway. Aging 13 37724906
2025 ALDOC promotes neuroblastoma progression and modulates sensitivity to chemotherapy drugs by enhancing aerobic glycolysis. Frontiers in immunology 11 40313939
2018 Metastasis Suppressor NME1 Directly Activates Transcription of the ALDOC Gene in Melanoma Cells. Anticancer research 11 30396920
2024 PPAR-γ agonists reactivate the ALDOC-NR2F1 axis to enhance sensitivity to temozolomide and suppress glioblastoma progression. Cell communication and signaling : CCS 9 38741139
2024 Overexpression of ALDOC Promotes Porcine Intramuscular and Intermuscular Fat Deposition by Activating the AKT-mTORC1 Signaling Pathway. Journal of agricultural and food chemistry 8 39428631
2025 Hypoxia regulates glycolysis through the HIF-1α/BMAL1/ALDOC axis to reduce oxaliplatin sensitivity in colorectal cancer. Journal of Cancer 5 40535800
2024 Overexpression of SLC2A1, ALDOC, and PFKFB4 in the glycolysis pathway drives strong drug resistance in 3D HeLa tumor cell spheroids. Biotechnology journal 4 39295558
1991 Mapping of silver fox genes: chromosomal localization of the genes for GOT2, AK1, ALDOC, ACP1, ITPA, PGP, and BLVR. Cytogenetics and cell genetics 2 1647290
2025 ALDOC and PGK1 coordinately induce glucose metabolism reprogramming and promote development of colorectal cancer. Molecular medicine (Cambridge, Mass.) 1 40518543
1990 [Mapping of the silver fox genome. III. Determination of the chromosomal localization of the GOT2, AK1, ALDOC, ACP1, ITPA, PGP and BLVR genes]. Genetika 1 2074010
2025 AldoC BAC-GFP transgenic mice as a reliable model for astrocyte identification and functional studies in the brain. Molecular brain 0 41339882
2025 FADS2 and ALDOC as potential adipose tissue biomarkers in obesity: responses to low-calorie diet-feeding. Journal of translational medicine 0 41444587