Affinage

UBE2B

Ubiquitin-conjugating enzyme E2 B · UniProt P63146

Length
152 aa
Mass
17.3 kDa
Annotated
2026-06-10
35 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

UBE2B (RAD6B/HHR6B) is an E2 ubiquitin-conjugating enzyme that operates across genome maintenance, transcriptional regulation, and signal amplification by partnering with distinct E3 ligases to determine substrate and ubiquitin-chain identity (PMID:10908344, PMID:18339854, PMID:38182926). In post-replication repair, UBE2B forms a stable heterodimer with the E3 ligase RAD18 that preferentially binds forked and single-stranded DNA at stalled replication forks through the RAD18 SAP domain, driving PCNA monoubiquitination and recruitment of translesion polymerase POL η (PMID:10908344, PMID:18363965); UBE2B redistributes from nucleoplasm to chromatin upon DNA damage in late S/G2 and is the principal mediator of translesion synthesis, with its activity also feeding into FANCD2 activation, homologous recombination, and H2AX monoubiquitination (PMID:14981545, PMID:31639439). Through its catalytic activity UBE2B builds K63-linked polyubiquitin on β-catenin at K394, generating a proteasome-insensitive stabilized pool that drives TCF/β-catenin transcription, while β-catenin reciprocally activates the UBE2B promoter to form a positive feedback loop (PMID:17050667, PMID:18339854, PMID:22705350). UBE2B further mono- and polyubiquitinates histones H2A and H2B, a chromatin modification induced downstream of androgen receptor signaling in Sertoli cells and essential for spermatogenesis, as RAD6B-null male mice lack histone polyubiquitination and are sterile (PMID:23863405, PMID:28825854). The enzyme also targets specific proteins for degradative ubiquitination, including the cAMP repressors hICERIIγ and hATF5 and the DNA methyltransferase DNMT3a (PMID:10373550, PMID:31576007), and is recruited as a bona fide E2 partner by the UBR4 N-degron E3 ligase via a hemiRING–UZI catalytic module that allosterically activates the Ub-loaded UBE2B (PMID:38182926). Additional E3 partnerships extend its reach to oncogenic signaling, where UBE2B cooperates with BIRC2 to K63-ubiquitinate TRAF1 and amplify NF-κB (PMID:41661096) and with RAD18 to monoubiquitinate and stabilize ZMYM2 (PMID:35313791).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1999 Medium

    Established UBE2B as a functional ubiquitin-conjugating enzyme in mammals by linking it to turnover of specific transcriptional repressors, moving it beyond a presumed DNA-repair-only role.

    Evidence Yeast genetic interaction screen, mammalian transfection assays, and Rad6B-null (mHR6B-/-) mice showing elevated ICER levels

    PMID:10373550

    Open questions at the time
    • Direct E3 ligase partner for hICERIIγ/hATF5 turnover not identified
    • Chain type on these substrates not defined
  2. 2000 Medium

    Identified the physical RAD18–UBE2B complex, defining the E2–E3 pairing that underlies lesion bypass.

    Evidence Co-expression in yeast with protein complex purification to near homogeneity

    PMID:10908344

    Open questions at the time
    • Substrate of the complex not yet shown in this study
    • Structural basis of the interaction unresolved at this point
  3. 2004 Medium

    Showed UBE2B is cell-cycle-regulated and recruited to chromatin upon DNA damage, connecting its abundance and localization to post-replication repair capacity and chemoresistance.

    Evidence Cell cycle synchronization, chromatin fractionation, overexpression/antisense knockdown, PRR and drug-sensitivity assays

    PMID:14981545

    Open questions at the time
    • Mechanism of damage-induced chromatin recruitment not defined
    • Direct ubiquitination targets on chromatin not enumerated here
  4. 2008 High

    Defined the mechanism of the RAD18–UBE2B complex at stalled forks by showing the RAD18 SAP domain mediates forked/ssDNA binding required for PCNA monoubiquitination and POL η recruitment.

    Evidence DNA-binding assays with purified complexes, SAP-domain mutagenesis, in vivo localization, UV-sensitivity rescue

    PMID:18363965

    Open questions at the time
    • Whether UBE2A vs UBE2B contributions differ at forks not separated
    • Kinetics of the conjugation reaction not measured
  5. 2008 High

    Revealed a non-degradative function: UBE2B builds K63-linked, proteasome-insensitive polyubiquitin on β-catenin to stabilize it and promote TCF transcription, establishing a Wnt-pathway role.

    Evidence Overexpression/siRNA in multiple cell lines, in vitro ubiquitination, cycloheximide chase, proteasome inhibition, TOP/Flash reporter

    PMID:18339854

    Open questions at the time
    • Cognate E3 ligase for β-catenin K63-ubiquitination not identified
    • Deubiquitinase counteracting this modification unknown
  6. 2006 Medium

    Closed a regulatory loop by showing UBE2B is itself a direct TCF-4/β-catenin/p300 transcriptional target, rationalizing constitutive UBE2B activity in metastatic cells.

    Evidence EMSA, ChIP, UV cross-linking, luciferase reporter assays in MCF10A vs MDA-MB-231 cells

    PMID:17050667

    Open questions at the time
    • In vivo relevance of the feedback loop to tumor progression not tested here
    • Other transcriptional inputs to the UBE2B promoter not mapped
  7. 2012 High

    Mapped the β-catenin interaction interface and the ubiquitination acceptor site (K394), providing residue-level mechanism for UBE2B-driven β-catenin stabilization.

    Evidence GST pulldown with deletion mutants, co-IP, in vitro/in vivo ubiquitination, K394R mutagenesis, TOP/Flash reporter

    PMID:22705350

    Open questions at the time
    • ~50% of ubiquitination persists in K394R, implying additional acceptor sites unmapped
    • Structural model of the UBE2B–β-catenin contact absent
  8. 2013 Medium

    Placed UBE2B downstream of androgen receptor signaling in Sertoli cells, linking hormonal control to histone H2A ubiquitylation in the male germline.

    Evidence Luciferase reporter, EMSA, ChIP, qRT-PCR, and IHC in Sertoli-cell-specific AR knockout mice

    PMID:23863405

    Open questions at the time
    • E3 ligase pairing for AR-induced H2A ubiquitylation not specified
    • Chain linkage on H2A not defined
  9. 2017 Medium

    Demonstrated that UBE2B-dependent histone H2A/H2B polyubiquitination is essential for spermatogenesis, with RAD6B loss causing male sterility.

    Evidence RAD6B and RNF8 knockout mouse models, histone ubiquitination assays, fertility assessment

    PMID:28825854

    Open questions at the time
    • Division of labor between RAD6B and RNF8 on H2A/H2B not fully resolved
    • Contribution of senescence vs direct chromatin defect to sterility not separated
  10. 2019 High

    Confirmed UBE2B as the principal driver of translesion synthesis using a selective inhibitor, extending its role to Fanconi anemia pathway activation and homologous recombination.

    Evidence RAD6-selective inhibitor SMI#9, siRNA, PCNA ubiquitination assays, DNA fiber, DR-GFP HR assay, xenograft

    PMID:31639439

    Open questions at the time
    • Mechanism of HR involvement independent of PCNA ubiquitination unclear
    • Off-target effects of SMI#9 not fully excluded
  11. 2019 Medium

    Showed UBE2B can degrade DNMT3a in vivo, coupling its activity to DNA demethylation and downstream cytoskeletal/behavioral plasticity in a heroin self-administration model.

    Evidence In vivo rat model, ubiquitination assays, co-IP, promoter methylation analysis, behavioral experiments

    PMID:31576007

    Open questions at the time
    • E3 ligase for DNMT3a degradation not identified
    • Chain type and acceptor lysine on DNMT3a undefined
  12. 2019 Medium

    Identified melanoma-selective RAD6B splice variants that remain catalytically active, indicating disease-associated isoforms retain conjugating function.

    Evidence RT-PCR splice variant characterization, Western blot, in vivo ubiquitin-conjugating assay, whole exome sequencing of melanomas

    PMID:31683936

    Open questions at the time
    • Substrate spectrum of the truncated variants not defined
    • Functional consequence for melanoma progression not demonstrated
  13. 2022 Medium

    Showed the RAD18–UBE2B pair can act non-degradatively to monoubiquitinate and stabilize ZMYM2, supporting ovarian cancer growth.

    Evidence Co-IP, immunofluorescence co-localization, cycloheximide chase, siRNA, ubiquitination assay, xenograft

    PMID:35313791

    Open questions at the time
    • Acceptor lysine on ZMYM2 not mapped
    • Mechanistic switch between mono- and polyubiquitination of ZMYM2 unresolved
  14. 2024 High

    Provided the structural basis for UBE2B's recruitment to an E3, defining how the UBR4 hemiRING–UZI module selects and allosterically activates UBE2A/UBE2B for N-degron substrates.

    Evidence Structure determination of the UBR4 E2–E3 complex, mutagenesis, in vitro ubiquitination assays

    PMID:38182926

    Open questions at the time
    • N-degron substrates ubiquitinated via this module not enumerated here
    • Cellular contexts where UBR4–UBE2B operates not established
  15. 2026 Medium

    Extended UBE2B's K63-ubiquitination activity to NF-κB signaling, showing a BIRC2–TRAF1–P65 feedforward loop that sustains its own expression in gastric cancer.

    Evidence Co-IP, K63-ubiquitination assay, ChIP, luciferase reporter, in vitro/in vivo proliferation assays

    PMID:41661096

    Open questions at the time
    • Acceptor lysine on TRAF1 not mapped
    • Generality of the loop beyond gastric cancer untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How UBE2B is partitioned among its many E3 partners and chain-type outputs (K48 degradative vs K63/monoubiquitin non-degradative) within a single cell remains unresolved.
  • No unifying model for E3 partner selection in vivo
  • Determinants of K48 vs K63 vs monoubiquitin output not defined
  • Relative contribution of UBE2A vs UBE2B across pathways unclear

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 4 GO:0016874 ligase activity 3
Localization
GO:0000228 nuclear chromosome 2 GO:0005634 nucleus 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-392499 Metabolism of proteins 3 R-HSA-4839726 Chromatin organization 2 R-HSA-73894 DNA Repair 2
Partners
BIRC2CTNNB1DNMT3ARAD18TRAF1UBR4ZMYM2
Complex memberships
RAD18-UBE2B (RAD6B) complex

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2000 Human RAD18 protein physically interacts with HHR6A (UBE2A) and HHR6B (UBE2B), forming stable protein complexes when co-expressed in yeast cells, purified to near homogeneity; this interaction is proposed to be critical for lesion bypass mechanisms. Co-expression in yeast, protein complex purification to near homogeneity Nucleic acids research Medium 10908344
2008 Human RAD18 complexed with RAD6B (UBE2B) preferentially binds forked and single-stranded DNA structures at stalled replication forks; the SAP domain of RAD18 (residues 248–282) is essential for this DNA binding and for PCNA monoubiquitination and recruitment of DNA polymerase eta to damage sites. DNA binding assays with purified protein complexes, SAP domain mutagenesis, in vivo localization, UV sensitivity rescue assays Genes to cells : devoted to molecular & cellular mechanisms High 18363965
1999 RAD6B (HHR6B/UBE2B) mediates ubiquitin-dependent proteolysis of the cAMP transcriptional repressors hICERIIγ and hATF5 in mammalian cells, requiring an active ubiquitin-conjugating enzyme; loss of murine Rad6B (mHR6B−/−) or dominant-negative Cdc34 elevates endogenous ICER protein levels, linking RAD6B to regulation of cAMP-induced transcription. Yeast-based genetic interaction screen, transfection assays in mammalian cells, analysis of Rad6B-null (mHR6B−/−) mice Molecular and cellular biology Medium 10373550
2004 RAD6B (UBE2B) protein expression is cell cycle regulated with maximal levels in late S/G2 phases; upon DNA damage (adriamycin, cisplatin), RAD6B redistributes from nucleoplasm to chromatin along with RAD18, PCNA, phosphohistone H3, and p53; RAD6B overexpression confers chemoresistance and enhanced post-replication repair (PRR) capacity, while antisense depletion causes chemosensitivity and loss of PRR. Cell cycle synchronization, in vivo chromatin crosslinking/fractionation, stable overexpression and antisense knockdown, PRR assay, drug sensitivity assays Oncogene Medium 14981545
2006 The human RAD6B (UBE2B) gene is a direct transcriptional target of TCF-4/β-catenin/p300; Rad6B promoter activity is repressed in normal MCF10A cells due to absence of transcriptionally active β-catenin on TCF binding sequences, and is constitutively active in metastatic MDA-MB-231 cells. Coexpression of β-catenin and p300 derepresses Rad6B promoter in MCF10A cells. EMSA, Western blot of EMSA, UV cross-linking, chromatin immunoprecipitation assay, luciferase reporter assay Molecular cancer research : MCR Medium 17050667
2008 Rad6B (UBE2B) overexpression in MCF10A breast cells induces β-catenin accumulation and stabilization via K63-linked polyubiquitination that renders β-catenin insensitive to 26S proteasome degradation; Rad6B silencing suppresses β-catenin mono- and polyubiquitination and transcriptional activity; in vitro ubiquitination assays confirm Rad6B directly mediates β-catenin polyubiquitination. Rad6B overexpression/siRNA knockdown in multiple cell lines, in vitro ubiquitination assay, cycloheximide chase, proteasome inhibitor treatment, TOP/Flash reporter assay, chromatin immunoprecipitation Cancer research High 18339854
2012 Rad6B (UBE2B) directly ubiquitinates β-catenin at lysine 394 (within Armadillo repeats 5–7); amino acids 131–181 of β-catenin and amino acids 50–116 of Rad6B are required for their interaction; K394R mutation in β-catenin abrogates ~50% of Rad6B-induced ubiquitination and significantly reduces β-catenin transcriptional activity and steady-state levels. GST pulldown with deletion mutants, co-immunoprecipitation, in vitro and in vivo ubiquitination assays, site-directed mutagenesis (Lys→Arg), TOP/Flash reporter assay Biochimica et biophysica acta High 22705350
2013 Ube2b (UBE2B) is a direct transcriptional target of androgen receptor (AR) in Sertoli cells; ligand-bound AR directly binds the androgen-responsive element in the Ube2b promoter, upregulates UBE2B expression, and promotes H2A ubiquitylation; UBE2B knockdown blocks testosterone-induced H2A ubiquitylation. Luciferase reporter assay, EMSA, ChIP, qRT-PCR, Western blot, immunohistochemistry in Sertoli cell-specific AR knockout (S-AR−/y) mice Biology of reproduction Medium 23863405
2015 UBE2B is the predominant E2 enzyme involved in myofibrillar protein loss under catabolic conditions in C2C12 myotubes; UBE2B knockdown decreases total ubiquitin conjugates by 18% and K48-linked ubiquitin conjugates (proteasome substrates) by 28% under dexamethasone-induced catabolism, indicating a direct role in ubiquitin-proteasome-dependent muscle protein breakdown. E2 expression screen, siRNA knockdown in C2C12 myotubes, quantification of polyUb conjugates and K48-linked ubiquitin conjugates by Western blot Journal of cachexia, sarcopenia and muscle Medium 27239408
2018 RAD6B (UBE2B) polyubiquitinates histones H2A and H2B; loss of RAD6B in male mice results in absence of histone polyubiquitination and male sterility; RNF8 (an E3 ligase) monoubiquitinates H2A and H2B. Senescence also contributes to RAD6B-null male sterility. RAD6B and RNF8 knockout mouse models, histone ubiquitination assays, offspring counting for fertility assessment Cell cycle (Georgetown, Tex.) Medium 28825854
2019 RAD6B (UBE2B) is a principal mediator of translesion synthesis (TLS): a RAD6-selective inhibitor (SMI#9) attenuates cisplatin-induced PCNA monoubiquitination, FANCD2 activation (Fanconi anemia pathway marker), TLS polymerase POL η recruitment, and restart of cisplatin-stalled replication forks; RAD6B silencing or SMI#9 also impairs homologous recombination independently of BRCA1 status; RAD6B modulates cisplatin-induced γH2AX via H2AX monoubiquitination. RAD6-selective small-molecule inhibitor (SMI#9), RAD6B siRNA knockdown, PCNA ubiquitination assays, DNA fiber assay, DR-GFP-based HR assay, foci formation assays, in vivo xenograft Biochimica et biophysica acta. Molecular basis of disease High 31639439
2019 Ube2b (UBE2B) mediates ubiquitination and degradation of DNMT3a in rat dorsal hippocampus following heroin self-administration; Ube2b-dependent DNMT3a degradation leads to demethylation of the CaMKK1 gene promoter, upregulating CaMKK1 and activating CaMKIα/βPIX/Rac1 signaling, which drives actin cytoskeleton remodeling and behavioral plasticity. In vivo model (heroin self-administration in rats), ubiquitination assays, co-immunoprecipitation, promoter methylation analysis, protein expression assays (Western blot), behavioral experiments Molecular psychiatry Medium 31576007
2022 UBE2B forms a heterodimeric complex with E3 ligase RAD18 and together monoubiquitinates ZMYM2 at the expense of its polyubiquitination, thereby stabilizing ZMYM2 protein; RAD18 knockdown impairs UBE2B-induced ZMYM2 monoubiquitination and destabilizes ZMYM2; UBE2B overexpression promotes ovarian cancer xenograft growth in a ZMYM2-dependent manner. Co-immunoprecipitation, immunofluorescence co-localization, cycloheximide chase assay, siRNA knockdown, ubiquitination assay, xenograft tumor model Bioengineered Medium 35313791
2024 UBR4 contains a catalytic module comprising a 'hemiRING' zinc finger, a helical-rich UZI subdomain, and an N-terminal affinity region; the crystal/cryo-EM structure of the UBR4 E2–E3 complex reveals atomic-level specificity determinants of the hemiRING toward cognate E2s UBE2A and UBE2B (UBE2B is a bona fide E2 partner of UBR4); the UZI subdomain allosterically modestly activates the Ub-loaded UBE2A/UBE2B∼Ub, and the intrinsically high lysine reactivity of these E2s cooperates with this activation for substrate specificity. Structure determination (E2–E3 complex), in vitro ubiquitination assays, mutagenesis, biochemical characterization Nature structural & molecular biology High 38182926
2019 RAD6B splice variants RAD6BΔexon4 and RAD6Bintron5ins, expressed selectively in melanoma but not normal melanocytes, are translated as 14 and 15 kDa proteins, respectively, and retain functional in vivo ubiquitin-conjugating activity despite their truncated nature. RT-PCR splice variant characterization, Western blot, in vivo ubiquitin conjugating activity assay, whole exome sequencing of patient melanomas Cells Medium 31683936
2026 UBE2B interacts with E3 ligase BIRC2 to catalyze K63-linked ubiquitination of TRAF1, thereby amplifying NF-κB signaling in gastric cancer; NF-κB subunit P65 directly binds the UBE2B promoter creating a feedforward loop; this UBE2B-BIRC2-TRAF1-P65 axis is a self-sustaining mechanism driving NF-κB hyperactivation and tumor proliferation. Co-immunoprecipitation, K63-ubiquitination assay, chromatin immunoprecipitation assay, luciferase reporter assay, in vitro and in vivo proliferation assays Molecular cancer research : MCR Medium 41661096
2025 UBE2B promotes ubiquitination and degradation of U2AF1 (U2 small nuclear RNA auxiliary factor 1) in endothelial cells during renal ischemia-reperfusion injury, leading to activation of the p53/p21 signaling pathway, endothelial apoptosis, and inhibited proliferation. UBE2B overexpression/knockdown in endothelial cell models, ubiquitination assay, co-immunoprecipitation, Western blot for p53/p21 pathway Molecular biology reports Low 41186784

Source papers

Stage 0 corpus · 35 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Up-regulation of miR-455-5p by the TGF-β-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B. The Journal of pathology 81 27235675
1999 Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. Molecular and cellular biology 69 10373550
2000 The human RAD18 gene product interacts with HHR6A and HHR6B. Nucleic acids research 61 10908344
2008 Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. Genes to cells : devoted to molecular & cellular mechanisms 58 18363965
2008 Rad6B is a positive regulator of beta-catenin stabilization. Cancer research 51 18339854
1992 Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. Genomics 49 1559696
2004 RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response. Oncogene 37 14981545
2003 Spermatid nuclear and sperm periaxonemal anomalies in the mouse Ube2b null mutant. Molecular reproduction and development 37 12784252
2012 Lysine 394 is a novel Rad6B-induced ubiquitination site on beta-catenin. Biochimica et biophysica acta 26 22705350
2018 Function of RAD6B and RNF8 in spermatogenesis. Cell cycle (Georgetown, Tex.) 24 28825854
2015 UBE2B is implicated in myofibrillar protein loss in catabolic C2C12 myotubes. Journal of cachexia, sarcopenia and muscle 24 27239408
2008 Novel variants in UBE2B gene and idiopathic male infertility. Journal of andrology 23 18497339
2006 Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. Molecular cancer research : MCR 23 17050667
2019 RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence. Biochimica et biophysica acta. Molecular basis of disease 22 31639439
2013 Identification of Ube2b as a novel target of androgen receptor in mouse sertoli cells. Biology of reproduction 22 23863405
2011 Rad6B acts downstream of Wnt signaling to stabilize β-catenin: Implications for a novel Wnt/β-catenin target. Journal of molecular signaling 22 21767405
2024 UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4. Nature structural & molecular biology 21 38182926
2008 Novel UBE2B-associated polymorphisms in an azoospermic/oligozoospermic population. Asian journal of andrology 21 18385908
2019 RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration. Frontiers in cellular neuroscience 17 31507381
2013 UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men. Molecular human reproduction 13 23378580
2015 A functional variant in the UBE2B gene promoter is associated with idiopathic azoospermia. Reproductive biology and endocrinology : RB&E 12 26223869
2022 UBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization. Bioengineered 11 35313791
2019 Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity. Molecular psychiatry 11 31576007
2023 From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism. Signal transduction and targeted therapy 10 36828823
2020 RAD6B Loss Disrupts Expression of Melanoma Phenotype in Part by Inhibiting WNT/β-Catenin Signaling. The American journal of pathology 9 33181138
2021 Upregulation of ubiquitin conjugating enzyme E2B (Ube2b) ameliorates neuropathic pain by regulating Kcna2 (potassium voltage-gated channel subfamily A member 2) in primary afferent neurons. Bioengineered 7 34632937
2019 Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization. Cells 7 31683936
2012 Genetic association of UBE2B variants with susceptibility to male infertility in a Northeast Chinese population. Genetics and molecular research : GMR 7 23079972
2009 Utility of DNA postreplication repair protein Rad6B in neoadjuvant chemotherapy response. Medical oncology (Northwood, London, England) 7 19466589
2021 The Role of RAD6B and PEDF in Retinal Degeneration. Neuroscience 4 34774969
2020 Loss of RAD6B induces degeneration of the cochlea in mice. Biochemical and biophysical research communications 4 32868078
2026 UBE2B Drives NF-κB Signaling and Gastric Cancer Progression through BIRC2-Mediated K63-Linked Ubiquitination of TRAF1. Molecular cancer research : MCR 1 41661096
2014 [UBE2B gene and male infertility: an update]. Zhonghua nan ke xue = National journal of andrology 1 24873167
2025 Targeting UBE2B-mediated U2AF1 degradation to alleviate endothelial dysfunction in renal ischemia-reperfusion injury: therapeutic potential of semaglutide. Molecular biology reports 0 41186784
2009 [Effect of hydroquinone on the expression of ubiquitin-conjugating enzyme Rad6B in human L-02 hepatic cells]. Wei sheng yan jiu = Journal of hygiene research 0 19548583

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