Affinage

TSN

Translin · UniProt Q15631

Length
228 aa
Mass
26.2 kDa
Annotated
2026-06-10
94 papers in source corpus 12 papers cited in narrative 12 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

Translin (TSN) is an evolutionarily conserved, oligomeric nucleic-acid-binding protein that links the metabolism of DNA, mRNA, and microRNA to germ-cell development, mesenchymal differentiation, and metabolic control (PMID:15987823, PMID:32408014). It was first defined as a sequence-specific DNA-binding protein (BCLF-1/ReHF-1) that recognizes recombination-hotspot motifs within the BCL-2 major breakpoint region, immunoglobulin DH segments, and chromosomal translocation breakpoint junctions in lymphoid cells, where it exists natively as a ~30 kDa multimeric protein (PMID:8134113, PMID:7947454). In germ cells, TSN binds specific meiotic mRNAs and a pachytene noncoding RNA in the nucleus and is required for normal meiosis, with Tsn-null mice showing reduced sperm count and elevated meiotic apoptosis (PMID:15987823); it also binds and stabilizes microRNAs such as miR-122a in postmeiotic cells (PMID:18567644). Mechanistically, TSN assembles into homo-octamers and into hetero-octamers with TRAX (TSNAX) that constitute a microRNA-degrading enzyme; an active-site mutation (Tsnax E126A) that abolishes catalysis without disrupting complex formation phenocopies Tsn loss, establishing that developmental loss of this enzymatic microRNA-degrading activity — not scaffolding — drives robust adiposity and hepatic steatosis through selective microRNA accumulation (PMID:29740830, PMID:30647452, PMID:32408014). Beyond nucleic-acid catabolism, TSN facilitates nuclear-to-cytoplasmic mRNA transport: downstream of β1-adrenergic/cAMP-PKA-CREB signaling it traffics IBSP mRNA to enable translation in keloid fibroblasts (PMID:42106323), and it acts as an intracellular L-arginine sensor promoting T-cell survival (PMID:27745970). The TSN-partner TSNAX additionally nucleates a separate axis through TSNAXIP1, a testis-specific interactor required for sperm head morphogenesis and flagellar beating that functions distinctly from TSN-TSNAX (PMID:36598146, PMID:37389156).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1994 Medium

    Established the founding biochemical identity of TSN as a sequence-specific DNA-binding protein targeting recombination hotspots, raising the question of how it might contribute to chromosomal rearrangement.

    Evidence Gel-shift, UV cross-linking, and nuclear fractionation from lymphoid lines (BCLF-1) plus biophysical sizing of the native protein (ReHF-1)

    PMID:7947454 PMID:8134113

    Open questions at the time
    • Did not demonstrate a causal role in translocation formation in vivo
    • Did not resolve oligomeric architecture or whether DNA binding is the primary physiological activity
  2. 2005 High

    Reframed TSN from a DNA-binding factor to an RNA-associated protein with a defined developmental requirement, by linking it to specific meiotic transcripts and a meiotic phenotype.

    Evidence In vivo cross-linking IP and RNA gel-shift in pachytene spermatocytes with Tsn-null mouse controls and nuclear/cytoplasmic fractionation

    PMID:15987823

    Open questions at the time
    • Did not establish whether mRNA binding regulates stability, localization, or translation of targets
    • Mechanism connecting RNA association to meiotic apoptosis unresolved
  3. 2008 Medium

    Extended TSN's RNA repertoire to microRNAs and assigned a posttranscriptional stabilization function, distinct from its mRNA roles.

    Evidence RNA binding and in vivo stability measurement of miR-122a in testis germ cells

    PMID:18567644

    Open questions at the time
    • Single microRNA examined
    • Did not reconcile a stabilizing role with the later microRNA-degrading enzyme activity
  4. 2018 Medium

    Defined the molecular machines TSN forms — homo-octamers and TSN/TRAX hetero-octamers — and connected them to RISC activation and a mesenchymal differentiation phenotype in knockout mice.

    Evidence Tsn-/- mouse models, biochemical complex characterization, histology (review consolidating experimental findings)

    PMID:29740830

    Open questions at the time
    • Did not pinpoint which complex drives the bone marrow/differentiation phenotype
    • Catalytic versus structural contribution not separated
  5. 2019 Medium

    Identified a striking organismal consequence of TSN loss — robust, metabolically protective adiposity — opening the question of which TSN activity underlies it.

    Evidence Tsn knockout mouse body composition, tolerance tests, and tissue molecular analyses

    PMID:30647452

    Open questions at the time
    • Causal molecular driver of adiposity not identified
    • Tissue and developmental window of action undefined
  6. 2020 High

    Resolved the mechanistic basis of the metabolic phenotype, proving it depends on the developmental TN/TX microRNA-degrading enzymatic activity rather than scaffolding.

    Evidence Tsnax E126A active-site knock-in, conditional floxed alleles, reciprocal Co-IP, microRNA sequencing, body composition

    PMID:32408014

    Open questions at the time
    • The specific microRNAs and downstream metabolic targets mediating adiposity not fully defined
    • Developmental cell type executing the program unidentified
  7. 2016 Medium

    Assigned TSN a signaling role as an intracellular L-arginine sensor governing T-cell survival, distinct from its nucleic-acid functions.

    Evidence Proteome-wide structural probing by mass spectrometry plus knockout T-cell clones

    PMID:27745970

    Open questions at the time
    • Atomic mechanism of L-arginine sensing by TSN unresolved
    • TSN is one of three hits; specific downstream survival effectors unclear
  8. 2023 Medium

    Delineated a TSNAX-anchored, TSN-independent axis by characterizing TSNAXIP1 as a testis-specific partner required for sperm head morphogenesis and flagellar beating.

    Evidence CRISPR/Cas9 knockout mice, fertility and sperm motility/morphology assays, axonemal co-fractionation and immunolocalization

    PMID:36598146 PMID:37389156

    Open questions at the time
    • Direct functional contribution of TSN itself to the sperm phenotype not established
    • Molecular basis of TSNAXIP1 action on flagellar waveform undefined
  9. 2026 Medium

    Placed TSN in adrenergic-CREB signaling as an mRNA transport factor, linking neuronal signaling to fibrotic/osteogenic matrix output.

    Evidence Single-cell RNA-seq, genetic ablation of ADRB1 and TSN, pharmacological inhibition, mRNA transport/translation analysis in keloid fibroblasts

    PMID:42106323

    Open questions at the time
    • Generality of TSN-mediated mRNA transport beyond IBSP unclear
    • How CREB activation directs TSN cargo selectivity not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How TSN's distinct activities — sequence-specific DNA binding, microRNA degradation, mRNA stabilization/transport, and amino-acid sensing — are coordinated or partitioned across cell types and complex states remains unresolved.
  • No unifying structural or regulatory model connecting the catalytic and transport/sensing functions
  • Cell-type-specific determinants of TSN homo- versus hetero-octamer function unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 2 GO:0003723 RNA binding 2 GO:0140098 catalytic activity, acting on RNA 2 GO:0140299 molecular sensor activity 1
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 1
Pathway
R-HSA-1430728 Metabolism 2 R-HSA-8953854 Metabolism of RNA 2
Partners
TSNAXTSNAXIP1
Complex memberships
TSN/TRAX (Translin-TRAX) octamerTranslin homo-octamer

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 BCLF-1 (now TSN/Translin) was identified as a nuclear DNA-binding protein that specifically binds to a novel target sequence within the 150-bp major breakpoint region of the Bcl-2 oncogene and within Ig diversity (DH) gene family sequences at recombination hotspot regions. BCLF-1 was found to be specifically expressed in lymphoid lineage cells, and was suggested to be identical or closely related to ReHF-1. DNA-protein binding assays (gel shift), UV cross-linking, nuclear protein fractionation from lymphoid cell lines Oncogene Medium 7947454 8134113
1994 ReHF-1 (now TSN/Translin) binds to novel target-like sequences at chromosomal breakpoint junctions in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11) translocations, and also to the 3' end of the human V delta 3 gene segment. The protein has a molecular weight of ~30 kDa, exists as a multimeric protein in native form (by gel filtration and sedimentation velocity), and is expressed in gamma-delta T cells and B cell precursor ALLs with rearranged TCR delta locus. UV cross-linking analysis, gel filtration chromatography, sedimentation velocity centrifugation, DNA binding assays International immunology Medium 7947454
2005 TSN (Translin) associates in vivo with specific meiotic mRNAs (encoding diazepam-binding inhibitor-like 5, arylsulfatase A, a tetratricopeptide repeat protein, and ring finger protein 139) as well as a noncoding RNA expressed in pachytene spermatocytes. In pachytene spermatocytes TSN is found predominantly in nuclei (unlike postmeiotic cells where it is cytoplasmic). Tsn-null mice show reduced sperm count and high meiotic apoptosis, indicating a critical function during meiosis. In vivo reversible cross-linking followed by immunoprecipitation with anti-TSN antibody; RNA gel-shift assays confirming specific binding; Tsn-null mouse controls; nuclear/cytoplasmic fractionation Biology of reproduction High 15987823
2008 TSN (Translin) binds to microRNA miR-122a in late-stage germ cells of mouse testis, and this binding increases the in vivo stability of miR-122a, establishing a posttranscriptional stabilization function for TSN on microRNAs in addition to its roles with mRNAs. RNA binding assays, in vivo stability measurements of miR-122a in TSN-expressing vs. control contexts Journal of andrology Medium 18567644
2018 Translin (TSN) and its partner TRAX form complexes that participate in RNA-induced silencing complex (RISC) activation and microRNA depletion occurring in Dicer deficiency. TSN homo-octamers and TSN/TRAX hetero-octamers have been characterized as distinct functional complexes involved in nucleic acid metabolism. At the cellular level, Tsn−/− mice display delayed endochondral ossification, progressive bone marrow failure with ectopic osteogenesis and adipogenesis, implicating TSN/TRAX in mesenchymal cell differentiation. Genetic mouse models (Tsn-/- mice), biochemical characterization of TSN homo-octamer and TSN/TRAX hetero-octamer complexes, histological analysis Annals of the New York Academy of Sciences Medium 29740830
2019 Deletion of Translin (Tsn) from mice induces robust adiposity and hepatic steatosis while preserving normal glucose tolerance. Tsn KO mice show increased subcutaneous fat accumulation, elevated circulating adiponectin, and decreased Tnfα expression in hepatic and adipose tissue compared to adiposity-matched high-fat diet WT mice, suggesting that TSN deletion promotes a metabolically protective form of adiposity. Translin knockout mouse model, body composition scanning, glucose and insulin tolerance tests, histological analysis, plasma and tissue molecular analyses International journal of obesity Medium 30647452
2020 Genetic inactivation of the Translin (TN)/Trax (TX) microRNA-degrading enzyme — either by Tsn deletion or by the Tsnax E126A point mutation that specifically abolishes enzymatic activity without impairing TN/TX complex formation or co-precipitation — phenocopies robust adiposity with selective increases in specific microRNAs. This establishes that the metabolic phenotype of Tsn KO mice is driven by loss of TN/TX microRNA-degrading enzymatic activity during development, rather than by loss of protein scaffolding functions. Selective deletion of Tsn from adipocytes or hepatocytes, or global conditional deletion in adulthood, does not recapitulate elevated adiposity. Tsnax E126A knock-in mice, floxed Tsn/Tsnax conditional alleles, co-immunoprecipitation, microRNA sequencing, body composition analysis Molecular metabolism High 32408014
2023 TSN (Translin) binds to TSNAX (translin-associated factor X), and TSNAXIP1 was identified as a TSNAX-interacting protein. Unlike the TSN-TSNAX complex (whose disruption causes abnormal testicular vacuoles), TSNAXIP1 knockout mice show reduced male fertility, impaired sperm motility with asymmetric flagellar waveforms, and no testicular section abnormalities. TSNAXIP1 localizes to the sperm tail and co-fractionates with axonemal proteins, indicating a role in regulating sperm flagellar beating patterns distinct from TSN-TSNAX functions. CRISPR/Cas9 knockout mice, fertility assays, sperm motility analysis, subcellular fractionation, immunolocalization Andrology Medium 36598146
2023 TSNAXIP1, a binding partner of TSNAX (which partners with TSN/Translin), is essential for sperm head morphogenesis. TSNAXIP1 KO males are sub-fertile with smaller testes, lower sperm count, and flower-shaped sperm head malformation with abnormal neck anchorage, despite normal spermatogenesis. TSNAXIP1 is testis-specific and its domains are highly conserved between mouse and human. CRISPR-Cas9 knockout mice, fertility assays, histological analysis, sperm morphology assessment Reproductive medicine and biology Medium 37389156
2016 Three transcriptional regulators including TSN were identified as sensors of intracellular L-arginine levels in human T cells. Proteome-wide structural probing combined with knockout T cell clone analysis established that TSN promotes T cell survival in response to elevated L-arginine concentrations. Proteome-wide structural alteration probing by high-resolution mass spectrometry, knockout T cell clones Cell Medium 27745970
2026 In keloid fibroblasts, CREB-activated Translin (TSN) facilitates nuclear-to-cytoplasmic mRNA transport of IBSP (integrin-binding sialoprotein), enabling efficient translation in RUNX2+ fibroblasts downstream of β1-adrenergic receptor/cAMP-PKA-CREB signaling. This establishes TSN as a mechanistic link between adrenergic neuronal signaling and fibrotic/osteogenic matrix overproduction via RNA trafficking. Single-cell RNA sequencing, genetic ablation of ADRB1 and TSN, pharmacological inhibition, mechanistic analysis of mRNA transport and translation Nature communications Medium 42106323
2023 In a genome-wide CRISPRi screen in human induced neurons, knockdown of TSN (Translin) was found to increase phosphorylated S6 ribosomal protein (pS6) levels, and specifically caused neurons to become resistant to loss of growth factor signaling (pS6 levels remained comparable to growth-factor-stimulated controls even without growth factor stimulation), placing TSN in a pathway that regulates mTOR/S6 signaling in neurons. Genome-wide CRISPRi screen in human iPSC-derived neurons, FACS enrichment based on pS6 levels, validation of individual knockdowns bioRxivpreprint Low 38168415

Source papers

Stage 0 corpus · 94 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Cell 1402 27745970
2008 Aedes aegypti uses RNA interference in defense against Sindbis virus infection. BMC microbiology 185 18366655
2000 Infection of primary human monocytes by Epstein-Barr virus. Journal of virology 101 10684275
2010 Expression of transient receptor potential ankyrin 1 (TRPA1) in the rat trigeminal sensory afferents and spinal dorsal horn. The Journal of comparative neurology 90 20034057
2007 Biological effects of toosendanin, a triterpenoid extracted from Chinese traditional medicine. Progress in neurobiology 85 17363132
2017 Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition. Science (New York, N.Y.) 79 28546213
2016 Tudor staphylococcal nuclease: biochemistry and functions. Cell death and differentiation 70 27612014
2020 T-cell activation and immune memory enhancement induced by irreversible electroporation in pancreatic cancer. Clinical and translational medicine 69 32508058
2006 Mechanisms of orofacial pain control in the central nervous system. Archives of histology and cytology 64 16819148
2012 Induction of RNA interference genes by double-stranded RNA; implications for susceptibility to RNA interference. Insect biochemistry and molecular biology 63 22634162
2023 Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1. International journal of molecular medicine 60 37800609
2023 Small-molecule toosendanin reverses macrophage-mediated immunosuppression to overcome glioblastoma resistance to immunotherapy. Science translational medicine 58 36791206
2012 Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake. Biochemical pharmacology 46 23022229
2022 Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer. JCI insight 45 36509291
2018 IDO1 impairs NK cell cytotoxicity by decreasing NKG2D/NKG2DLs via promoting miR-18a. Molecular immunology 44 30268986
2017 Proofreading of Peptide-MHC Complexes through Dynamic Multivalent Interactions. Frontiers in immunology 43 28228754
2017 Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1. Oncology reports 42 28184921
2008 The DNA/RNA-binding protein, translin, binds microRNA122a and increases its in vivo stability. Journal of andrology 39 18567644
2018 Anti-cancer effect of toosendanin and its underlying mechanisms. Journal of Asian natural products research 38 29629572
2018 Insights Into SND1 Oncogene Promoter Regulation. Frontiers in oncology 36 30619748
2021 Toosendanin and isotoosendanin suppress triple-negative breast cancer growth via inducing necrosis, apoptosis and autophagy. Chemico-biological interactions 35 34742683
2015 Maternal protein restriction increases respiratory and sympathetic activities and sensitizes peripheral chemoreflex in male rat offspring. The Journal of nutrition 34 25934662
2017 UPF1 helicase promotes TSN-mediated miRNA decay. Genes & development 31 28827400
2020 PD-1 does not mark tumor-infiltrating CD8+ T cell dysfunction in human gastric cancer. Journal for immunotherapy of cancer 30 32753468
2021 Chronic Pain Causes Peripheral and Central Responses in MIA-Induced TMJOA Rats. Cellular and molecular neurobiology 29 33387118
2019 Clinical analysis of Chinese anti-low-density-lipoprotein-receptor-associated protein 4 antibodies in patients with myasthenia gravis. European journal of neurology 29 31050101
2018 Toosendanin inhibits adipogenesis by activating Wnt/β-catenin signaling. Scientific reports 29 29545541
1994 Nuclear proteins binding to a novel target sequence within the recombination hotspot regions of Bcl-2 and the immunoglobulin DH gene family. Oncogene 29 8134113
2017 Multifunctional RNA Binding Protein OsTudor-SN in Storage Protein mRNA Transport and Localization. Plant physiology 28 29084903
2022 Toosendanin, a late-stage autophagy inhibitor, sensitizes triple-negative breast cancer to irinotecan chemotherapy. Chinese medicine 27 35524271
2020 Toosendanin-induced apoptosis in colorectal cancer cells is associated with the κ-opioid receptor/β-catenin signaling axis. Biochemical pharmacology 27 32387457
2020 Genome-wide association studies for sperm traits in Assaf sheep breed. Animal : an international journal of animal bioscience 27 33573944
2005 Meiotic messenger RNA and noncoding RNA targets of the RNA-binding protein Translin (TSN) in mouse testis. Biology of reproduction 26 15987823
2017 Tanshinone inhibits neuronal cell apoptosis and inflammatory response in cerebral infarction rat model. International journal of immunopathology and pharmacology 25 28402151
1994 Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11). International immunology 25 7947454
2015 microRNA-29b Mediates the Antifibrotic Effect of Tanshinone IIA in Postinfarct Cardiac Remodeling. Journal of cardiovascular pharmacology 24 25636075
2022 Toosendanin reduces cisplatin resistance in ovarian cancer through modulating the miR-195/ERK/β-catenin pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology 23 36610147
2022 Chemo-Enzymatic Modification of the 5' Cap To Study mRNAs. Accounts of chemical research 22 35420432
2022 Tanshinone IIA exerts autophagic cell death through down-regulation of β-catenin in renal cell carcinoma cells. Biochimie 21 35654241
2023 Toosendanin induced hepatotoxicity via triggering PERK-eIF2α-ATF4 mediated ferroptosis. Toxicology letters 20 36801351
2021 Mechanisms involved in the anti-tumor effects of Toosendanin in glioma cells. Cancer cell international 19 34530814
2019 Integrated Proteomics, Biological Functional Assessments, and Metabolomics Reveal Toosendanin-Induced Hepatic Energy Metabolic Disorders. Chemical research in toxicology 19 30848893
2024 Preserving mitochondrial homeostasis protects against drug-induced liver injury via inducing OPTN (optineurin)-dependent Mitophagy. Autophagy 18 39099169
2023 TanshinoneⅡA inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via 14-3-3η/Akt/Beclin1 pathway. European journal of pharmacology 18 37406848
2019 A novel method for stabilizing microRNA mimics. Biochemical and biophysical research communications 18 30799083
2021 Toosendanin triggered hepatotoxicity in zebrafish via inflammation, autophagy, and apoptosis pathways. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 17 34454086
2020 Identification, functional prediction, and key lncRNA verification of cold stress-related lncRNAs in rats liver. Scientific reports 17 31949263
2022 Toosendanin inhibits colorectal cancer cell growth through the Hedgehog pathway by targeting Shh. Drug development research 16 35656621
2020 Toosendanin Suppresses Glioma Progression Property and Induces Apoptosis by Regulating miR-608/Notch Axis. Cancer management and research 16 32494206
2023 Toosendanin inhibits osteoclast formation and alleviate postmenopausal osteoporosis by regulating the p38 signaling pathway. International immunopharmacology 15 36702075
2017 Tanshinone-induced ERs suppresses IGFII activation to alleviate Ang II-mediated cardiac hypertrophy. Journal of receptor and signal transduction research 14 28812967
2025 Tangshenning formula alleviates tubular injury in diabetic kidney disease via the Sestrin2/AMPK/PGC-1α axis: Restoration of mitochondrial function and inhibition of ferroptosis. Journal of ethnopharmacology 13 40043828
2023 Unraveling tumor specific neoantigen immunogenicity prediction: a comprehensive analysis. Frontiers in immunology 13 37564650
2022 Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction. Pharmaceuticals (Basel, Switzerland) 12 36558960
2020 TSN inhibits cell proliferation, migration, invasion, and EMT through regulating miR-874/HMGB2/β-catenin pathway in gastric cancer. Neoplasma 11 32484696
2025 WWOX-mediated p53/SAT1 and NRF2/FPN1 axis contribute to toosendanin-induced ferroptosis in hepatocellular carcinoma. Biochemical pharmacology 10 39894307
2024 Gut microbial interactions based on network construction and bacterial pairwise cultivation. Science China. Life sciences 10 38600293
2023 Testis-specific proteins, TSNAXIP1 and 1700010I14RIK, are important for sperm motility and male fertility in mice. Andrology 10 36598146
2023 The mode of action of tapasin on major histocompatibility class I (MHC-I) molecules. The Journal of biological chemistry 10 36758805
2023 Toosendanin-induced apoptosis of CMT-U27 is mediated through the mitochondrial apoptotic pathway. Veterinary and comparative oncology 10 36809669
2022 Toosendanin activates caspase-1 and induces maturation of IL-1β to inhibit type 2 porcine reproductive and respiratory syndrome virus replication via an IFI16-dependent pathway. Veterinary research 10 35906635
2024 Toosendanin induces hepatotoxicity via disrupting LXRα/Lipin1/SREBP1 mediated lipid metabolism. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 9 38570025
2024 Toosendanin alleviates acute lung injury by reducing pulmonary vascular barrier dysfunction mediated by endoplasmic reticulum stress through mTOR. Phytomedicine : international journal of phytotherapy and phytopharmacology 9 39615214
2021 Tanshinone IIA inhibits Leu27IGF-II-induced insulin-like growth factor receptor II signaling and myocardial apoptosis via estrogen receptor-mediated Akt activation. Environmental toxicology 9 34655285
2020 Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion. Molecular metabolism 9 32408014
2024 A genome-wide gene-environmental interaction study identified novel loci for the relationship between ambient air pollution exposure and depression, anxiety. Ecotoxicology and environmental safety 8 39357380
2023 Design, synthesis, and anti-triple negative breast cancer activity of novel Toosendanin derivatives. Bioorganic & medicinal chemistry letters 8 36781147
2022 Multistep pathogenesis of chronic myelomonocytic leukemia in patients. European journal of haematology 8 35299281
2019 Deletion of translin (Tsn) induces robust adiposity and hepatic steatosis without impairing glucose tolerance. International journal of obesity (2005) 7 30647452
2024 Toosendanin induces hepatotoxicity by restraining autophagy and lysosomal function through inhibiting STAT3/CTSC axis. Toxicology letters 6 38460807
2023 Synergistic Anti-Tumor Effect of Toosendanin and Paclitaxel on Triple-Negative Breast Cancer via Regulating ADORA2A-EMT Related Signaling. Advanced biology 6 37401656
2023 Characterization and transcriptomic analyses of the toxicity induced by toosendanin in Spodoptera frugipreda. Gene 6 37898452
2018 Mesenchymal cell differentiation and diseases: involvement of translin/TRAX complexes and associated proteins. Annals of the New York Academy of Sciences 6 29740830
2022 Tangshenning Attenuates High Glucose-Induced Podocyte Injury via Restoring Autophagy Activity through Inhibiting mTORC1 Activation. Journal of diabetes research 5 35799948
2021 Ternary supramolecular nanocomplexes for superior anticancer efficacy of natural medicines. Nanoscale 5 34533154
2025 Toosendanin promotes prostate cancer cell apoptosis, ferroptosis and M1 polarization via USP39-mediated PLK1 deubiquitination. Naunyn-Schmiedeberg's archives of pharmacology 4 40056202
2023 Clinical characteristics of anti-AChR-MuSK-LRP4 antibody-negative myasthenia gravis in China. Muscle & nerve 4 36945795
2023 TSNAXIP1 is required for sperm head formation and male fertility. Reproductive medicine and biology 4 37389156
2023 A Comparative Study of Tumor-Specificity and Neurotoxicity between 3-Styrylchromones and Anti-Cancer Drugs. Medicines (Basel, Switzerland) 4 37505064
2023 Antitumor effect of toosendanin on oral squamous cell carcinoma via suppression of p-STAT3. BMC oral health 3 37946196
2019 Disease association of human tumor suppressor genes. Molecular genetics and genomics : MGG 3 30945018
2025 Toosendanin Induces Hepatotoxicity by Facilitating ALOX5-Mediated Lipid Peroxidation and Sensitizing Cells to Ferroptosis. Pharmaceuticals (Basel, Switzerland) 2 40732365
2022 Investigation of interaction between dexamethasone/pheniramine and trypsin by fluorescence, UV-vis, CD, and molecular docking. Journal of biomolecular structure & dynamics 2 35098895
2022 CTPS cytoophidia formation affects cell cycle progression and promotes TSN‑induced apoptosis of MKN45 cells. Molecular medicine reports 2 36043523
2025 Toosendanin Induces Cell Cycle Arrest and Apoptosis to Suppress Diffuse Large B-Cell Lymphoma Growth by Inhibiting PI3Kα/β and PLK1 Signaling. Phytotherapy research : PTR 1 39949030
2025 Anisotropic Tussah Silk Nanofiber Scaffolds for Accelerating Wound Repair. ACS applied bio materials 1 41102893
2025 Toosendanin inhibits STING signaling pathway to alleviate ulcerative colitis via blocking LYN kinase and STING protein. Biochemical pharmacology 1 41187884
2023 Isolation and Characterization of an Anti-Osteoporotic Compound from Melia toosendan Fructus. Pharmaceutics 1 37896213
1985 Alterations of the bacteriophage T7 and T3 DNA packaging pathway in Escherichia coli mutant TSN B. Virology 1 3880979
2026 Catecholaminergic neurons boost fibroblast osteogenic activity in keloid. Nature communications 0 42106323
2025 Tanshinone IIA ameliorates septic immunosuppression by balancing the Th17/Treg cell ratio and modulating Treg function after induction of autophagy. Archives of biochemistry and biophysics 0 40334959
2025 DFO-Loaded Tussah Silk Nanofibrous Membranes for Guided Bone Regeneration. ACS omega 0 40949287
2025 TSN Disrupts Fanconi Anemia Pathway Activation Through JAK/STAT1-Mediated Transcriptional Repression of FA Core Subunits in Bladder Cancer. Dose-response : a publication of International Hormesis Society 0 41346410
2023 Genome-wide CRISPRi Screen in Human iNeurons to Identify Novel Focal Cortical Dysplasia Genes. bioRxiv : the preprint server for biology 0 38168415

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