Affinage

TRPV6

Transient receptor potential cation channel subfamily V member 6 · UniProt Q9H1D0

Length
765 aa
Mass
87.3 kDa
Annotated
2026-06-10
100 papers in source corpus 39 papers cited in narrative 39 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TRPV6 is a highly Ca2+-selective cation channel that mediates apical Ca2+ entry into epithelia and is physiologically essential for transepithelial Ca2+ transport (PMID:21540454, PMID:22878123). It assembles as a homotetramer (and can form heterotetramers with TRPV5) with an intracellular skirt for allosteric modulation, and its Ca2+ selectivity is set by a ring of aspartate side chains in the selectivity filter, with the pore residue D541/D542 essential for permeation (PMID:12574114, PMID:27296226, PMID:15184369). Channel opening proceeds through an α-to-π helical transition in the pore-lining S6 helix at an alanine hinge, producing an iris-like gating motion (PMID:29258289). The basal state is autoinhibited by two intramolecular contacts—an S4–S5 linker to TRP-helix interaction and a pre-S1 to TRP-helix interaction—both of which are relieved by direct binding of PIP2, the principal activating lipid demonstrated using purified channel reconstituted in lipid bilayers (PMID:21810903, PMID:32829285); conversely, Ca2+ influx drives phospholipase C-mediated PIP2 depletion that underlies Ca2+-induced inactivation (PMID:18390907). Activity is further tuned by Ca2+-dependent calmodulin binding and by direct gating inhibitors RGS2, Nipsnap1, and Numb1, while small molecules such as 2-APB close the channel through a defined S1–S4 pocket (PMID:15123711, PMID:29941865, PMID:16895908, PMID:18392847, PMID:23140583). Surface delivery and stability are governed by the S100A10–annexin 2 complex binding the C-terminal VATTV motif (required for plasma-membrane targeting), GDP-bound Rab11a-mediated trafficking, kinase inputs (WNK3, SGK1/Akt), klotho/β-glucuronidase-mediated deglycosylation, and Nedd4-2-mediated ubiquitination and degradation (PMID:12660155, PMID:16354700, PMID:18495742, PMID:20843805, PMID:18768590). In vivo, functional TRPV6 channels are required for intestinal Ca2+ absorption, maternal-fetal placental Ca2+ transport supporting fetal bone mineralization, and epididymal Ca2+ reabsorption essential for male fertility, with basolateral CaSR signaling negatively regulating intestinal TRPV6 via PLC (PMID:21540454, PMID:18348695, PMID:22878123, PMID:31013259). Beyond bulk Ca2+ handling, TRPV6-mediated Ca2+ entry controls keratinocyte differentiation and, through Ca2+-dependent activation of PP2A, suppresses IGF/Akt signaling to maintain epithelial cell quiescence (PMID:17550901, PMID:31526479).

Mechanistic history

Synthesis pass · year-by-year structured walk · 23 steps
  1. 2003 High

    Establishing the channel's quaternary architecture was needed to interpret all later functional and structural work; TRPV6 was shown to be a tetramer that can mix with TRPV5 to create functionally distinct channels.

    Evidence Sucrose gradient sedimentation, co-IP, and concatemeric channel electrophysiology in HEK293 cells

    PMID:12574114

    Open questions at the time
    • Native epithelial stoichiometry of homo- versus heterotetramers not quantified
    • No atomic structure at this stage
  2. 2003 High

    How TRPV6 reaches the plasma membrane was unknown; the S100A10–annexin 2 complex was identified as binding the C-terminal VATTV motif and being required for surface targeting and channel activity.

    Evidence Yeast two-hybrid, GST pull-down, co-IP, T600A mutagenesis, annexin 2 siRNA, and electrophysiology in HEK293 cells

    PMID:12660155

    Open questions at the time
    • Step in the trafficking itinerary controlled by the complex not resolved
    • Regulation of complex assembly addressed only later
  3. 2004 High

    The basis of Ca2+-dependent feedback regulation was addressed by showing calmodulin binds TRPV6 in a Ca2+-dependent manner at defined N- and C-terminal motifs and positively modulates current.

    Evidence GST pull-down, co-IP, whole-cell patch clamp, and chimeric channel analysis in HEK293 cells

    PMID:15123711

    Open questions at the time
    • Structural coupling of CaM binding to gating not defined
    • Relationship to PIP2-dependent inactivation not integrated
  4. 2004 High

    Whether TRPV6 is constitutively open was tested; under physiological Ca2+ buffering it is not, and divalent block plus the pore aspartate D542 govern permeation behavior.

    Evidence Whole-cell/perforated patch clamp, Fura-2, and pore/truncation mutagenesis in HEK293 cells

    PMID:15184369

    Open questions at the time
    • Molecular trigger for physiological opening in epithelia not defined here
  5. 2006 High

    Mechanisms of surface regulation and direct gating control were expanded by identifying GDP-Rab11a as a trafficking partner and RGS2 as a direct, trafficking-independent gating inhibitor, with NHERF4 as an additional C-terminal PDZ interactor.

    Evidence Co-IP, confocal colocalization, Ca2+ uptake/surface biotinylation, yeast two-hybrid, and GST pull-down in epithelial cells and oocytes

    PMID:16354700 PMID:16565876 PMID:16895908

    Open questions at the time
    • Functional consequence of NHERF4 binding not established
    • How RGS2 alters gating structurally unknown
  6. 2008 Medium

    Multiple inputs converging on TRPV6 were defined: cAMP/PKA/calcineurin control of the annexin 2–S100A10 association, CypB isomerase-dependent activation, klotho/β-glucuronidase deglycosylation activation, and Nipsnap1 as a direct gating inhibitor.

    Evidence Co-IP, 45Ca uptake, oocyte Ca2+ assays, enzymatic deglycosylation, GST pull-down, and biotinylation across HEK293, Caco-2, oocyte and placental systems

    PMID:18187190 PMID:18392847 PMID:18445599 PMID:18495742

    Open questions at the time
    • Several findings rest on single-lab functional assays
    • Direct enzymatic action of klotho on the channel inferred from specificity not structurally shown
  7. 2008 High

    The physiological necessity of TRPV6 was established in vivo, showing it mediates maternal-fetal placental Ca2+ transport critical for fetal bone mineralization.

    Evidence Trpv6 knockout mice with 45Ca transport assays, immunohistochemistry, and qRT-PCR

    PMID:18348695

    Open questions at the time
    • Relative contribution of other Ca2+ pathways in placenta not quantified
  8. 2008 High

    The lipid and metabolic regulation of TRPV6 was clarified by showing Ca2+ influx activates PLC to deplete PIP2, driving Ca2+-induced inactivation.

    Evidence Whole-cell and excised patch clamp with rapamycin-inducible phosphatase and Ca2+ imaging

    PMID:18390907

    Open questions at the time
    • Identity of the PLC isoform in native epithelia not defined
  9. 2009 Medium

    Kinase and nucleotide inputs were defined: WNK3 and SGK1/Akt increase activity and surface abundance, while ATP binding to the ARD/C-terminus prevents rundown and PKCβII phosphorylation opposes it.

    Evidence Oocyte co-expression, Ca2+/current assays, surface biotinylation, ATP-binding studies, and mutagenesis

    PMID:18768590 PMID:19805577 PMID:20041238

    Open questions at the time
    • SGK1/PIKfyve effect relies on indirect Cl- current readout (Low confidence)
    • Direct phosphosites on TRPV6 versus partners not fully resolved
  10. 2008 High

    The structural basis of the regulatory cytoplasmic domain was probed by solving the ankyrin repeat domain, showing it does not bind ATP or CaM unlike TRPV1, implying a distinct regulatory role.

    Evidence X-ray crystallography at 1.7 Å with ATP- and CaM-agarose pull-downs and SEC

    PMID:18232717

    Open questions at the time
    • Functional role of the variable third-finger loop and its phosphosites not tested in vivo
  11. 2010 Medium

    Negative protein-stability control was defined by showing Nedd4-2 ubiquitinates TRPV6 and reduces its abundance, predominantly via the proteasome.

    Evidence Oocyte co-expression, Ca2+ influx, ubiquitination assays, proteasome/lysosome inhibitors, and HECT/WW domain mutagenesis

    PMID:20843805

    Open questions at the time
    • Physiological context regulating Nedd4-2 action on TRPV6 not established
  12. 2011 High

    PIP2 was demonstrated to be a direct activator using purified, reconstituted channel, decoupling lipid activation from cellular machinery and explaining ATP-dependent recovery via PIP2 resynthesis.

    Evidence Planar lipid bilayer reconstitution of purified TRPV6 plus excised inside-out patch clamp and PI4K inhibition

    PMID:21810903

    Open questions at the time
    • Lipid-binding site not resolved structurally until later mutational work
  13. 2011 High

    In vivo significance for fertility was established by showing a pore-dead D541A channel impairs epididymal Ca2+ absorption and male fertility, localizing TRPV6 to apical epididymal epithelium.

    Evidence D541A knock-in mice with luminal Ca2+ measurements, absorption assays, immunolocalization, and sperm assays

    PMID:21540454

    Open questions at the time
    • Downstream coupling to sperm physiology mechanistic detail limited
  14. 2011 Medium

    A receptor-driven mode of TRPV6 activation was identified in prostate cells, with PSGR activating TRPV6 through Src kinase independent of G-protein signaling.

    Evidence Electrophysiology, Ca2+ imaging, TRPV6 siRNA, co-IP, and Src inhibition

    PMID:21349844

    Open questions at the time
    • Direct Src target residues on TRPV6 not mapped
    • Single-lab cancer-cell context
  15. 2012 High

    Genetic null mice confirmed that epididymal and fertility phenotypes arise from loss of channel function rather than channel-independent effects of the pore mutant, and established intestinal Ca2+ absorption requires functional channels; an extended non-AUG-initiated N-terminus enhances trafficking; Numb1 was identified as a direct inhibitor.

    Evidence Trpv6 knockout and D541A knock-in mice, 45Ca absorption assays, mass spectrometry of placental protein, and co-IP/FRET/mutagenesis

    PMID:22427671 PMID:22878123 PMID:23140583 PMID:23612980

    Open questions at the time
    • Tissue distribution and regulation of the extended isoform not fully mapped
    • Numb1 inhibition mechanism on gating not structurally resolved
  16. 2016 High

    Atomic structure of TRPV6 revealed the tetrameric assembly, the aspartate ring selectivity filter, and a multi-site Ca2+ permeation pathway, providing the framework for all mechanistic interpretation.

    Evidence X-ray crystallography of rat TRPV6 at 3.25 Å

    PMID:27296226

    Open questions at the time
    • Single conformational state; gating transition not yet captured at this stage
  17. 2016 Medium

    The native epithelial output of TRPV6 Ca2+ entry was linked to a calcium-activated chloride conductance (TMEM16A) coupling in epididymal principal cells, connecting Ca2+ entry to downstream transport.

    Evidence Single-cell patch clamp, pharmacology, in vivo luminal perfusion, and immunofluorescence colocalization

    PMID:27481714

    Open questions at the time
    • Direct physical coupling between TRPV6 and TMEM16A not demonstrated
  18. 2017 High

    Open and closed cryo-EM structures defined the gating mechanism as an α-to-π S6 transition at an alanine hinge with iris-like opening, and confirmed PIP2 increases open probability.

    Evidence Cryo-EM of human TRPV6 in two states plus electrophysiology

    PMID:29258289

    Open questions at the time
    • PIP2 binding pose not resolved in these maps
  19. 2018 High

    The pharmacological inhibitor 2-APB was localized to a defined S1–S4 cytoplasmic pocket, showing closure occurs by modulating protein–lipid interactions.

    Evidence Crystal/cryo-EM of human and rat TRPV6 with 2-APB plus Y467A mutagenesis and functional assays

    PMID:29941865

    Open questions at the time
    • Selectivity of this pocket relative to other TRPV channels not addressed
  20. 2019 High

    Two regulatory questions were answered: basolateral CaSR signaling restrains intestinal TRPV6 Ca2+ absorption via PLC, and TRPV6-mediated constitutive Ca2+ influx enforces epithelial quiescence by activating PP2A to suppress IGF-Akt/Erk signaling.

    Evidence Ussing chambers with D541A mice and oocyte co-expression; zebrafish genetic deletion with channel-dead rescue, PP2A assays, and human colon cancer cells

    PMID:31013259 PMID:31526479

    Open questions at the time
    • Direct CaSR-PLC-TRPV6 molecular coupling not resolved
    • Quiescence pathway demonstrated in single-lab models
  21. 2020 Medium

    The autoinhibitory architecture of resting TRPV6 was defined as two intramolecular TRP-helix interactions relieved by PIP2 binding at S5/C-terminal cationic residues, unifying lipid activation with gating control.

    Evidence Site-directed mutagenesis, blocking peptides, patch clamp, and Ca2+ imaging

    PMID:32829285

    Open questions at the time
    • Interactions inferred functionally without a corresponding apo/PIP2-bound structure in this study
  22. 2020 Medium

    A skeletal role beyond Ca2+ absorption was proposed, with TRPV6 suppressing osteoclastogenesis through IGF-PI3K-AKT signaling, paralleling its quiescence-promoting role.

    Evidence Trpv6 knockout mice, micro-CT, TRAP/pit assays, lentiviral manipulation, and pathway inhibitor rescue in osteoclasts

    PMID:33159483

    Open questions at the time
    • Cell-autonomous versus systemic Ca2+ contributions not fully separated
  23. 2022 High

    A pathological gating modality was identified: ethanol and acetaldehyde directly activate TRPV6 via a histidine-containing site, driving Ca2+ influx that disrupts intestinal tight junctions.

    Evidence Patch clamp, Ca2+ imaging, Trpv6-/- mice and organoids, Caco-2 monolayers, photoaffinity labeling, and mutagenesis

    PMID:35705057

    Open questions at the time
    • Structural definition of the alcohol-binding pocket not resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the diverse regulatory inputs (CaM, PIP2 autoinhibition, kinases, trafficking partners, ubiquitination) are integrated dynamically within a single epithelial cell to set TRPV6 set-point in vivo remains unresolved.
  • No unified quantitative model linking lipid, Ca2+, and post-translational regulation
  • Structural states bound to physiological protein regulators (CaM, RGS2, S100A10) not solved
  • Native channel composition and regulation across tissues incompletely mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 4 GO:0008289 lipid binding 3 GO:0060089 molecular transducer activity 3 GO:0005198 structural molecule activity 1
Localization
GO:0005886 plasma membrane 4 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-382551 Transport of small molecules 4 R-HSA-162582 Signal Transduction 3 R-HSA-9609507 Protein localization 3
Partners
ANXA2CALM1NEDD4LNUMBRAB11ARGS2S100A10TRPV5
Complex memberships
S100A10-annexin 2 complexTRPV5/TRPV6 heterotetramerTRPV6 homotetramer

Evidence

Reading pass · 39 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 TRPV6 forms homotetramers and can form heterotetramers with TRPV5; the tetrameric stoichiometry was confirmed by sucrose gradient sedimentation (~400 kDa), co-immunoprecipitation from oocytes, and electrophysiological analysis of concatemeric channels. Heterotetrameric TRPV5/TRPV6 complexes show distinct Ca2+-dependent inactivation, Ba2+ selectivity, and pharmacological block compared to homotetramers. Sucrose gradient sedimentation, co-immunoprecipitation, concatemeric channel electrophysiology in HEK293 cells The EMBO journal High 12574114
2003 S100A10 binds specifically to the conserved C-terminal VATTV motif of TRPV6 (with the first threonine, T600, being critical); S100A10 forms a heterotetrameric complex with annexin 2, and the S100A10–annexin 2 complex is required for routing TRPV6 to the plasma membrane. Mutation T600A abolishes S100A10 binding, redistributes TRPV6 to a sub-plasma-membrane compartment, and eliminates channel activity. Knockdown of annexin 2 by siRNA inhibits TRPV6-mediated currents. Yeast two-hybrid, GST pull-down, co-immunoprecipitation, site-directed mutagenesis, siRNA knockdown, electrophysiology in HEK293 cells, immunofluorescence The EMBO journal High 12660155
2004 Calmodulin (CaM) binds TRPV6 in a Ca2+-dependent manner and positively regulates TRPV6 channel activity. CaM binding sites were localized to the transmembrane domain, an N-terminal 1-5-10 motif (residues 88–97), and a C-terminal 1-8-14 motif (residues 643–656). Overexpression of Ca2+-insensitive CaM mutants (CaM1234, CaM34) significantly reduced Ca2+ and Na+ currents of TRPV6-expressing HEK293 cells but not TRPV5 cells, implicating EF-hands 3 and 4 of CaM's C-lobe. GST pull-down, co-immunoprecipitation, whole-cell patch clamp, chimeric channel analysis in HEK293 cells The Journal of biological chemistry High 15123711
2016 Crystal structure of rat TRPV6 at 3.25 Å resolution revealed: tetrameric assembly with an intracellular 'skirt' involved in allosteric modulation; Ca2+ selectivity determined by a ring of aspartate side chains in the selectivity filter; multiple cation-binding sites along the pore axis and extracellular vestibule defining a Ca2+ permeation mechanism. X-ray crystallography at 3.25 Å resolution Nature High 27296226
2017 Cryo-EM structures of human TRPV6 in open and closed states revealed that channel opening involves an α-to-π helical transition in the pore-lining S6 helix at an alanine hinge below the selectivity filter, causing S6 helices to bend and rotate (iris-like gating). The selectivity filter adopts similar conformations in both states. Open probability is increased by PIP2. Cryo-electron microscopy, electrophysiology Nature High 29258289
2018 2-APB binds to TRPV6 in a pocket formed by the cytoplasmic half of the S1–S4 transmembrane helix bundle. 2-APB induces channel closure by modulating protein–lipid interactions, as shown by comparing wild-type and high-affinity Y467A mutant structures. Mutagenesis and functional analysis confirmed the binding site. Crystal and cryo-EM structures of human and rat TRPV6 bound to 2-APB, mutagenesis, functional assays Nature communications High 29941865
2008 Crystal structure of the TRPV6 ankyrin repeat domain (ARD) at 1.7 Å revealed a conserved large twist between repeats 4 and 5 and a variable third finger loop with putative regulatory phosphorylation sites. Pull-down assays showed the TRPV6 ARD does not bind ATP or calmodulin, contrasting with TRPV1 ARD, indicating a distinct regulatory role for the TRPV6 ARD. X-ray crystallography (1.7 Å), ATP-agarose and calmodulin-agarose pull-down assays, size exclusion chromatography Biochemistry High 18232717
2006 GDP-bound Rab11a directly and specifically interacts with TRPV5 and TRPV6 via a conserved stretch in their C-termini. Rab11a colocalizes with TRPV6 in vesicular structures beneath the apical membrane. Co-expression of GDP-locked Rab11a significantly decreased TRPV6-mediated Ca2+ uptake by reducing channel surface expression. Rab11a thus mediates TRPV6 trafficking to the plasma membrane in a novel GDP-bound, direct cargo-interaction mode. Co-immunoprecipitation, confocal colocalization, Ca2+ uptake assays, surface expression analysis in epithelial cells and oocytes Molecular and cellular biology High 16354700
2008 Klotho (acting as a β-glucuronidase) and β-glucuronidase specifically increase TRPV6 (and TRPV5) activity but not TRPV4 or TRPM6, suggesting activation via N-oligosaccharide hydrolysis on the channel. Deglycosylation by endoglycosidase-F also stimulated TRPV6 activity. Ca2+-influx measurements in transfected HEK293 cells, enzymatic deglycosylation Nephrology, dialysis, transplantation Medium 18495742
2006 RGS2 interacts with the N-terminal domain of TRPV6 in a Ca2+-independent manner (identified by yeast two-hybrid and GST pull-down). RGS2 overexpression reduces Na+ and Ca2+ currents of TRPV6 but not TRPV5. The inhibitory effect is not due to altered channel trafficking (cell-surface biotinylation was unchanged), suggesting direct effects on gating. DeltaN-RGS2 lacking the N-terminal domain does not inhibit TRPV6, and the effect is GPCR-independent. Yeast two-hybrid, GST pull-down, whole-cell electrophysiology, cell-surface biotinylation in HEK293 cells The Journal of biological chemistry High 16895908
2008 Ca2+ influx through TRPV6 activates phospholipase C, causing depletion of PIP2, which contributes to Ca2+-induced inactivation of TRPV6. Ba2+ (which does not activate PLC) does not cause inactivation. Dialysis of DiC8-PIP2 inhibited Ca2+-dependent inactivation; PIP2 activated TRPV6 in excised patches; rapamycin-inducible PI(4,5)P2 5-phosphatase inhibited TRPV6 currents. PI(4)P had no significant effect. Whole-cell and excised patch-clamp, rapamycin-inducible phosphatase system, Ca2+ imaging The Journal of biological chemistry High 18390907
2011 PIP2 is a direct activator of TRPV6: reconstituted purified TRPV6 in planar lipid bilayers showed high activity in presence of PIP2 but not PI(4)P. Intracellular ATP supports TRPV6 activity indirectly by serving as substrate for type III PI4-kinases to resynthesize PIP2; MgATP reactivated TRPV6 after rundown in excised patches, an effect blocked by PI4K inhibitors. Excised inside-out patch clamp, planar lipid bilayer reconstitution with purified channel, pharmacological inhibition of PI4K FASEB journal High 21810903
2008 Cyclophilin B (CypB) co-purifies with TRPV6 from human placenta (also with annexin A2) and co-expression of CypB with TRPV6 in Xenopus oocytes significantly increases TRPV6-mediated Ca2+ uptake. This stimulatory effect is reversed by cyclosporin A (which inhibits CypB's peptidyl-prolyl cis/trans isomerase activity), suggesting CypB activates TRPV6 through its isomerase activity. Protein enrichment/co-purification from human placenta, Xenopus oocyte Ca2+ uptake assay, pharmacological inhibition with cyclosporin A The Journal of biological chemistry Medium 18445599
2009 ATP binds directly to TRPV6 (at sites within the ankyrin repeat domain and C-terminus), reduces whole-cell current increments, and prevents channel rundown (EC50 ~380 µM). PKCβII-mediated phosphorylation at defined ARD and C-terminal sites counteracts ATP-dependent stabilization, constituting a metabolic switch for Ca2+ influx. Biochemical ATP-binding studies, patch-clamp electrophysiology, site-directed mutagenesis of ARD and C-terminal residues FASEB journal Medium 19805577
2010 Nedd4-2 (HECT ubiquitin E3 ligase) down-regulates TRPV6 protein abundance and Ca2+ influx by increasing TRPV6 ubiquitination and decreasing its stability (partially via proteasomal but not lysosomal pathway). The HECT domain is essential for both inhibition and association. WW1 and WW2 domains interact with TRPV6 terminal regions and their integrity limits the degree of TRPV6 ubiquitination. Xenopus oocyte co-expression, Ca2+ influx assays, ubiquitination assays, proteasome/lysosome inhibitors, mutagenesis The Journal of biological chemistry Medium 20843805
2008 The annexin 2–S100A10 complex association with TRPV6 is regulated by cAMP/PKA/calcineurin A (CnA) signaling: forskolin-stimulated cAMP increases annexin 2–S100A10 complex formation (blocked by PKA or CnA inhibitors), and CnA-dependent dephosphorylation of annexin 2 mediates the interaction with TRPV6. PKA and CnA inhibitors attenuated 45Ca uptake in Caco-2 cells. Co-immunoprecipitation, 45Ca uptake assays, pharmacological inhibitors (PKA, CnA), cell biology in 16HBE14o- and Caco-2 cells Cell calcium Medium 18187190
2006 NHERF4 (PDZ protein) interacts with TRPV6 via the fourth PDZ domain binding a conserved region in the TRPV6 C-terminus, distinct from the NHERF2 binding site. Interaction confirmed by yeast two-hybrid, GST pull-down, and co-immunoprecipitation. Yeast two-hybrid, GST pull-down, co-immunoprecipitation in HEK293 cells and oocytes Pflugers Archiv Medium 16565876
2008 Nipsnap1 was identified as a novel TRPV6-interacting protein (by GST pull-down/bioinformatics) that abolishes TRPV6 currents without reducing plasma membrane expression of TRPV6, suggesting direct inhibition of channel gating rather than trafficking. GST pull-down, electrophysiology, cell-surface biotinylation, RT-PCR, immunohistochemistry Pflugers Archiv Medium 18392847
2011 Male mice carrying the TRPV6-D541A pore mutation (rendering the channel nonfunctional) show severely impaired fertility due to failure of Ca2+ absorption by epididymal epithelium, resulting in ~10-fold higher Ca2+ in cauda epididymis luminal fluid. TRPV6 was localized to the apical membrane of epididymal epithelium (not in spermatozoa), establishing that TRPV6-mediated Ca2+ absorption in the epididymis is essential for sperm motility and viability. Knock-in mouse model (D541A), Ca2+ concentration measurements, Ca2+ absorption assays, immunolocalization, sperm functional assays Science signaling High 21540454
2012 Trpv6 knockout mice (deletion of transmembrane/pore-forming and C-terminal regions) phenocopy the TRPV6-D541A pore mutant regarding epididymal Ca2+ handling and male fertility defects, arguing against residual channel-independent functions of the D541A mutant. Trpv6 knockout mouse (exon deletion), comparison with D541A knock-in, Ca2+ uptake assays, sperm function tests The Journal of biological chemistry High 22427671
2008 TRPV6 is required for maternal-fetal Ca2+ transport: Trpv6 knockout fetuses had significantly lower fetal blood Ca2+, lower amniotic fluid Ca2+, ~40% lower 45Ca transport from mother to fetus, and lower ash weight (bone mineralization). TRPV6 mRNA and protein were localized in intraplacental and extraplacental yolk sac, co-localizing with calbindin-D9K. Trpv6 knockout mice, 45Ca transport assays, immunohistochemistry, qRT-PCR Journal of bone and mineral research High 18348695
2012 TRPV6-D541A knockin mice (non-functional pore) show significantly impaired intestinal Ca2+ uptake under Ca2+-deficient diet conditions, establishing that functional TRPV6 channels mediate transepithelial Ca2+ absorption in the intestine, particularly under low-Ca2+ dietary challenge. TRPV6-D541A knockin mouse model, 45Ca intestinal absorption assay, metabolic cage measurements, protein expression analysis American journal of physiology. Gastrointestinal and liver physiology High 22878123
2004 Under physiological intracellular Ca2+ buffering conditions, TRPV6 does not form constitutively open channels in HEK293 cells; channel activity requires chelation of intracellular Ca2+ (with EGTA). Monovalent cations permeate TRPV6 when Ca2+ permeation is absent, indicating extracellular divalent cation block. The C-terminal domain required for calmodulin binding is not necessary for this regulation; the pore residue D542 is essential for channel function. Whole-cell and perforated patch clamp, Fura-2 microfluorimetry, site-directed mutagenesis (D542A, truncation mutant) in HEK293 cells The Journal of biological chemistry High 15184369
2013 The in vivo TRPV6 protein has an extended N-terminus: translation initiates at a non-AUG codon (ACG, decoded as methionine) upstream of the annotated AUG (which is not used). The extended full-length protein has similar channel properties to the shorter form in vitro, but increased trafficking to the plasma membrane and provides an additional scaffold for channel assembly. Mass spectrometry of endogenous placenta protein, cell biology/trafficking assays, electrophysiology The Journal of biological chemistry Medium 23612980
2011 G protein-coupled receptor PSGR activates endogenous TRPV6 channels in prostate cells via Src kinase. PSGR stimulation enhances cytosolic Ca2+ through TRPV6; the Ca2+ signal has biophysical characteristics of TRPV6 currents; Src kinase activation occurs independently of G-protein activation, presumably through direct PSGR–Src interaction. siRNA knockdown of TRPV6 confirmed channel identity. Electrophysiology, live-cell Ca2+ imaging, siRNA knockdown, biochemical co-immunoprecipitation, Src kinase inhibition The Journal of biological chemistry Medium 21349844
2009 WNK3 positively regulates TRPV6 activity in a kinase-dependent manner; the kinase-inactive WNK3-D294A mutation abolishes the effect. WNK3 increases Ca2+ influx and Na+ current mediated by TRPV6, and enhances delivery of mature (glycosylated) TRPV6 to the plasma membrane via the secretory pathway; the effect is abolished by the microtubule inhibitor colchicine. Xenopus oocyte co-expression, Ca2+ uptake assays, voltage clamp, surface biotinylation, exocytosis assays, kinase-dead mutagenesis American journal of physiology. Renal physiology Medium 18768590
2009 SGK1 and PKB/Akt increase TRPV6 activity and plasma membrane abundance. PIKfyve, phosphorylated by SGK1 at S318, further augments TRPV6 activity when co-expressed with active SGK1; the S318A-PIKfyve mutant lacking the SGK1 phosphorylation site fails to enhance TRPV6 activity. Xenopus oocyte co-expression, Ca2+-activated Cl- current recording as indirect readout of TRPV6-mediated Ca2+ influx, immunohistochemistry, Western blotting The Journal of membrane biology Low 20041238
2014 TRPV6 translocates to the plasma membrane in prostate cancer cells via an Orai1/TRPC1-mediated Ca2+/Annexin I/S100A11 pathway. TRPV6-mediated Ca2+ entry increases cell survival (proliferation and apoptosis resistance). Xenograft models confirmed increased aggressiveness of TRPV6-overexpressing tumors. Co-immunoprecipitation, Ca2+ imaging, siRNA knockdown, xenograft mouse models, immunohistochemistry Proceedings of the National Academy of Sciences Medium 25172921
2007 TRPV6 mediates Ca2+ entry in human keratinocytes and is required for Ca2+-induced differentiation: siRNA-mediated TRPV6 silencing impairs differentiated phenotype, reduces differentiation markers (involucrin, transglutaminase-1, cytokeratin-10), disrupts cell morphology and stratification. 1,25-Dihydroxyvitamin D3 dose-dependently increases TRPV6 expression and Ca2+ uptake, promoting differentiation. siRNA knockdown, Ca2+ uptake assays (Fura-2), RT-PCR, immunoblotting in primary human keratinocytes The Journal of biological chemistry Medium 17550901
2007 TRPV6 controls prostate cancer cell (LNCaP) proliferation: siRNA knockdown of TRPV6 decreases proliferation rate, reduces S-phase accumulation, and decreases PCNA expression. TRPV6-mediated Ca2+ entry activates NFAT transcription factor downstream. TRPV6 also contributes to apoptosis resistance. siRNA knockdown, cell cycle analysis, Ca2+ imaging, NFAT reporter assays in LNCaP cells Oncogene Medium 17533368
2019 Activation of the Ca2+-sensing receptor (CaSR) on the basolateral membrane of intestinal epithelium directly attenuates Ca2+ absorption via TRPV6: cinacalcet (calcimimetic) decreased net Ca2+ flux in Ussing chambers in a TRPV6-dependent manner (absent in TRPV6-D541A mice), and inhibited Ca2+ flux through TRPV6 when co-expressed with CaSR in oocytes. PLC inhibitor U73122 prevented cinacalcet-mediated TRPV6 inhibition. Ussing chamber Ca2+ flux assays, TRPV6-D541A knockin mice, Xenopus oocyte co-expression, pharmacological inhibition JCI insight High 31013259
2010 TRPV6 permeates heavy metal cations including Zn2+, Cd2+, Ba2+, Sr2+, Mn2+, La3+, and Gd3+ in addition to Ca2+, as shown by live-cell ion imaging (Fura-2, Newport Green DCF) and patch clamp in hTRPV6-expressing HEK293 cells. At higher concentrations, Cd2+, La3+, and Gd3+ are efficient inhibitors of TRPV6-mediated Ca2+ influx. Live-cell ion imaging (Fura-2, Newport Green DCF), whole-cell patch clamp, 45Ca uptake assays in HEK293 cells Cell calcium Medium 21146870
2012 Numb1 isoform interacts with TRPV6 via an aspartate at residue 716 (TRPV6) and arginine at residue 434 (Numb1), as identified by co-immunoprecipitation, FRET, and C-terminal truncation mutagenesis. Numb1 negatively regulates TRPV6 activity: its expression decreases cytosolic Ca2+ in TRPV6-transfected cells, and a Numb1 mutant lacking the TRPV6-binding site fails to inhibit TRPV6. Co-immunoprecipitation, FRET, C-terminal truncation mutagenesis, Ca2+ measurements in HEK293 and cancer cells Cell calcium Medium 23140583
2020 TRPV6 autoinhibition is maintained by two intramolecular interactions: S4–S5 linker to C-terminal TRP helix (L/C; mediated by Arg470:Trp593) and N-terminal pre-S1 to TRP helix (N/C; mediated by Trp321:Ile597). Disruption of either interaction by mutations or blocking peptides activates TRPV6. The N/C interaction depends on L/C but not vice versa. PIP2 binds three cationic residues in S5/C-terminus, suppresses both interactions, and activates TRPV6. Site-directed mutagenesis, blocking peptides, patch-clamp electrophysiology, Ca2+ imaging iScience Medium 32829285
2016 In rat cauda epididymal principal cells, a constitutively active TRPV6-like Ca2+ current is coupled to a calcium-activated chloride conductance (TMEM16A). TRPV6 and TMEM16A proteins co-localize at the apical membrane. Removal of extracellular Ca2+ attenuates both currents; lanthanide block inhibits the TRPV6-like component first, then CaCC. In vivo perfusion showed substantial Ca2+ reabsorption from epididymal lumen suppressed by ruthenium red. Patch clamp in single epididymal cells, pharmacological inhibition, in vivo luminal perfusion, immunofluorescence colocalization, mRNA detection The Journal of general physiology Medium 27481714
2019 In zebrafish, Trpv6 functions as a cell-autonomous regulator of epithelial quiescence: Trpv6-mediated constitutive Ca2+ influx activates PP2A, which suppresses IGF-mediated Akt-Tor and Erk signaling to maintain cellular quiescence. Genetic deletion or pharmacological blockade of Trpv6 caused epithelial cells to exit quiescence and re-enter the cell cycle; re-introduction of Trpv6 but not a channel-dead mutant restored quiescence. Zebrafish genetic deletion, pharmacological inhibition, cell cycle analysis, Ca2+ imaging, PP2A activity assays, IGF signaling readouts, human colon cancer cell experiments eLife Medium 31526479
2022 TRPV6 is required for alcohol-induced intestinal barrier dysfunction: ethanol and acetaldehyde activate TRPV6 ionic currents in Caco-2 cells; TRPV6 deficiency (Trpv6-/- mice and organoids) attenuates ethanol/acetaldehyde-induced Ca2+ influx, tight junction disruption, and barrier dysfunction. Photoaffinity labeling of 3-azibutanol identified a histidine as a putative alcohol-binding site; substitution of this histidine (and a nearby arginine) reduces ethanol-activated TRPV6 currents. Patch clamp electrophysiology, Ca2+ imaging, Trpv6-/- mouse model, intestinal organoids, Caco-2 monolayers, photoaffinity labeling, site-directed mutagenesis Cell reports High 35705057
2021 TRPV6 promotes breast cancer metastasis via NFATC2IP phosphorylation at Ser204 (with CDK5 as candidate kinase), which activates NFATC2 transcription factor, leading to upregulation of ADAMTS6 and increased cell migration. TRPV6 overexpression accelerates migration; TRPV6 suppression decreases it. Overexpression and siRNA knockdown, phosphorylation analysis, reporter assays, migration assays in breast cancer cells Cancer letters Low 34265397
2020 TRPV6 suppresses osteoclastogenesis via the IGF-PI3K-AKT signaling pathway: TRPV6 knockout mice develop osteoporosis with enhanced osteoclast differentiation and bone resorption. TRPV6 located on the osteoclast cell membrane decreases p-IGF/total-IGF, p-PI3K/total-PI3K, and p-AKT/total-AKT ratios. Blocking IGF-PI3K-AKT with inhibitors relieved the inhibitory effect of TRPV6 on osteoclasts. Trpv6 knockout mice, lentiviral overexpression/silencing in osteoclasts, micro-CT, TRAP staining, pit formation assay, Western blot for pathway components Cell proliferation Medium 33159483

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6. The EMBO journal 255 12574114
2003 Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. The EMBO journal 228 12660155
2007 TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways. Oncogene 200 17533368
2016 Crystal structure of the epithelial calcium channel TRPV6. Nature 184 27296226
2017 Opening of the human epithelial calcium channel TRPV6. Nature 166 29258289
2003 The epithelial calcium channels, TRPV5 & TRPV6: from identification towards regulation. Cell calcium 155 12765695
2008 The role of TRPV6 in breast carcinogenesis. Molecular cancer therapeutics 151 18245667
2003 Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney. Journal of the American Society of Nephrology : JASN 151 14569082
2003 Vitamin D receptor (VDR) knockout mice reveal VDR-independent regulation of intestinal calcium absorption and ECaC2 and calbindin D9k mRNA. The Journal of nutrition 139 12566470
2004 Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin. The Journal of biological chemistry 103 15123711
2012 Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer. Molecular cancer therapeutics 101 22807578
2018 Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB. Nature communications 96 29941865
2014 Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway. Apoptosis : an international journal on programmed cell death 96 24878626
2014 TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival. Proceedings of the National Academy of Sciences of the United States of America 96 25172921
2004 TRPV6 and prostate cancer: cancer growth beyond the prostate correlates with increased TRPV6 Ca2+ channel expression. Biochemical and biophysical research communications 96 15336984
2006 Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane. Molecular and cellular biology 95 16354700
2020 Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis. Gastroenterology 94 31930989
2011 Male fertility depends on Ca²+ absorption by TRPV6 in epididymal epithelia. Science signaling 93 21540454
2005 TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate. Pflugers Archiv : European journal of physiology 93 16044309
2012 The role of the TRPV6 channel in cancer. The Journal of physiology 89 22331416
2008 The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 89 18495742
2008 Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry 88 18232717
2008 Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 87 18348695
2010 Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis. Bone 85 20399919
2005 TRPV6 potentiates calcium-dependent cell proliferation. Cell calcium 77 16356545
2007 Uterine TRPV6 expression during the estrous cycle and pregnancy in a mouse model. American journal of physiology. Endocrinology and metabolism 75 17374692
2005 The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease. Naunyn-Schmiedeberg's archives of pharmacology 70 15747113
2007 TRPV6 is a Ca2+ entry channel essential for Ca2+-induced differentiation of human keratinocytes. The Journal of biological chemistry 69 17550901
2011 Alternative perspective on intestinal calcium absorption: proposed complementary actions of Ca(v)1.3 and TRPV6. Nutrition reviews 68 21729089
2020 TRPV6 as A Target for Cancer Therapy. Journal of Cancer 67 31897233
2008 Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels. The Journal of biological chemistry 67 18390907
2016 TRP channels in calcium homeostasis: from hormonal control to structure-function relationship of TRPV5 and TRPV6. Biochimica et biophysica acta. Molecular cell research 64 27913205
2013 The in vivo TRPV6 protein starts at a non-AUG triplet, decoded as methionine, upstream of canonical initiation at AUG. The Journal of biological chemistry 64 23612980
2018 TRPV6 Variants Interfere with Maternal-Fetal Calcium Transport through the Placenta and Cause Transient Neonatal Hyperparathyroidism. American journal of human genetics 63 29861107
2010 Heavy metal cations permeate the TRPV6 epithelial cation channel. Cell calcium 62 21146870
2016 Lidocaine inhibits the invasion and migration of TRPV6-expressing cancer cells by TRPV6 downregulation. Oncology letters 61 27446413
2003 The TRPV6 gene, cDNA and protein. Cell calcium 60 12765696
2004 Ca2+ dependence of the Ca2+-selective TRPV6 channel. The Journal of biological chemistry 58 15184369
2013 Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity. Cell calcium 55 23968883
2003 (Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6. Pflugers Archiv : European journal of physiology 55 12748856
2012 Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation. The Journal of biological chemistry 54 22427671
2012 Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption. American journal of physiology. Gastrointestinal and liver physiology 54 22878123
2022 Calcium selective channel TRPV6: Structure, function, and implications in health and disease. Gene 53 35031425
2011 Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P₂. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 51 21810903
2008 Expression of calcium channel TRPV6 in ovine epithelial tissue. Veterinary journal (London, England : 1997) 51 18701326
2006 Calcium store contents control the expression of TRPC1, TRPC3 and TRPV6 proteins in LNCaP prostate cancer cell line. Cell calcium 51 16529812
2012 Villin promoter-mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild-type and vitamin D receptor knockout mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 49 22589201
2009 Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear. Acta oto-laryngologica 49 19922080
2006 Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6. American journal of physiology. Renal physiology 49 16705151
2003 Store-operated Ca2+ current and TRPV6 channels in lymph node prostate cancer cells. The Journal of biological chemistry 48 14534305
2009 Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells. Molecular cancer research : MCR 47 19996302
2010 Chemical inhibitors of the calcium entry channel TRPV6. Pharmaceutical research 46 21057859
2006 Calcium channel TRPV6 expression in human duodenum: different relationships to the vitamin D system and aging in men and women. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 46 17002582
2009 Dynamic expression of calcium-regulatory molecules, TRPV6 and S100G, in the uterine endometrium during pregnancy in pigs. Biology of reproduction 45 19641180
2019 Activation of the calcium sensing receptor attenuates TRPV6-dependent intestinal calcium absorption. JCI insight 43 31013259
2007 Concerted action of associated proteins in the regulation of TRPV5 and TRPV6. Biochemical Society transactions 43 17233615
2004 Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+. The Journal of steroid biochemistry and molecular biology 43 15225790
2011 Coexpression and estrogen-mediated regulation of TRPV6 and PMCA1 in the human endometrium during the menstrual cycle. Molecular reproduction and development 42 21400627
2014 Knockout of TRPV6 causes osteopenia in mice by increasing osteoclastic differentiation and activity. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 41 24686448
2018 TRPV6 compound heterozygous variants result in impaired placental calcium transport and severe undermineralization and dysplasia of the fetal skeleton. American journal of medical genetics. Part A 40 30144375
2014 TRPV6 channels. Handbook of experimental pharmacology 40 24756713
2021 Calcium channel TRPV6 promotes breast cancer metastasis by NFATC2IP. Cancer letters 39 34265397
2011 G protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation. The Journal of biological chemistry 39 21349844
2006 RGS2 inhibits the epithelial Ca2+ channel TRPV6. The Journal of biological chemistry 39 16895908
2008 The human TRPV6 channel protein is associated with cyclophilin B in human placenta. The Journal of biological chemistry 38 18445599
2008 The annexin 2-S100A10 complex and its association with TRPV6 is regulated by cAMP/PKA/CnA in airway and gut epithelia. Cell calcium 37 18187190
2008 Parallel selection on TRPV6 in human populations. PloS one 37 18301763
2011 TRPV5 and TRPV6 in transcellular Ca(2+) transport: regulation, gene duplication, and polymorphisms in African populations. Advances in experimental medicine and biology 36 21290300
2009 Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells. American journal of physiology. Cell physiology 35 19295174
2020 TRPV6 variants confer susceptibility to chronic pancreatitis in the Chinese population. Human mutation 34 32383311
2010 Down-regulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2. The Journal of biological chemistry 34 20843805
2005 1,25-Dihydroxyvitamin D and 25-hydroxyvitamin D--mediated regulation of TRPV6 (a putative epithelial calcium channel) mRNA expression in Caco-2 cells. European journal of nutrition 34 16362534
2022 TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response. Cell reports 33 35705057
2012 The transient receptor potential channel TRPV6 is dynamically expressed in bone cells but is not crucial for bone mineralization in mice. Journal of cellular physiology 33 21732366
2009 Regulation of the Ca(2+) channel TRPV6 by the kinases SGK1, PKB/Akt, and PIKfyve. The Journal of membrane biology 33 20041238
2008 WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway. American journal of physiology. Renal physiology 33 18768590
2012 Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in human blood lymphocytes and Jurkat leukemia T cells. The Journal of membrane biology 30 23111462
2011 Decreased expression of the epithelial Ca2+ channel TRPV5 and TRPV6 in human renal cell carcinoma associated with vitamin D receptor. The Journal of urology 29 22019165
2020 The calcium channel TRPV6 is a novel regulator of RANKL-induced osteoclastic differentiation and bone absorption activity through the IGF-PI3K-AKT pathway. Cell proliferation 28 33159483
2019 TRPV6 and Cav1.3 Mediate Distal Small Intestine Calcium Absorption Before Weaning. Cellular and molecular gastroenterology and hepatology 28 31398491
2016 TRPV6 plays a new role in predicting survival of patients with esophageal squamous cell carcinoma. Diagnostic pathology 28 26818094
2009 Uterine and placental expression of TRPV6 gene is regulated via progesterone receptor- or estrogen receptor-mediated pathways during pregnancy in rodents. Reproductive biology and endocrinology : RB&E 28 19457270
2020 Autoinhibition of TRPV6 Channel and Regulation by PIP2. iScience 27 32829285
2006 Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4. Pflugers Archiv : European journal of physiology 27 16565876
2020 TRPV6 calcium channel directs homeostasis of the mammary epithelial sheets and controls epithelial mesenchymal transition. Scientific reports 26 32895467
2020 Trichostatin A Induces Autophagy in Cervical Cancer Cells by Regulating the PRMT5-STC1-TRPV6-JNK Pathway. Pharmacology 26 33142290
2019 TRPV6 Gene Mutation in a Dizygous Twin With Transient Neonatal Hyperparathyroidism. Journal of the Endocrine Society 26 30820485
2016 Coupling of TRPV6 and TMEM16A in epithelial principal cells of the rat epididymis. The Journal of general physiology 25 27481714
2008 Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity. Pflugers Archiv : European journal of physiology 25 18392847
2007 TRPV6. Handbook of experimental pharmacology 25 17217060
2020 Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor. RSC medicinal chemistry 24 33479695
2019 Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 24 30786075
2018 Δ9-tetrahydrocannabivarin impairs epithelial calcium transport through inhibition of TRPV5 and TRPV6. Pharmacological research 24 30170189
2013 Expression of TRPV6 and CaBP-D28k in the egg shell gland (uterus) during the oviposition cycle of the laying hen. British poultry science 24 23796121
2011 Acceleration of keratinocyte differentiation by transient receptor potential vanilloid (TRPV6) channel activation. Journal of the European Academy of Dermatology and Venereology : JEADV 24 21175869
2020 Novel TRPV6 mutations in the spectrum of transient neonatal hyperparathyroidism. The journal of physiological sciences : JPS 23 32646367
2012 Regulation of calcium influx and signaling pathway in cancer cells via TRPV6-Numb1 interaction. Cell calcium 22 23140583
2019 Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6. eLife 21 31526479
2011 Localisation and expression of TRPV6 in all intestinal segments and kidney of laying hens. British poultry science 21 21919579
2009 ATP modulates Ca2+ uptake by TRPV6 and is counteracted by isoform-specific phosphorylation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21 19805577

Missed literature

Know a paper Affinage missed for TRPV6? Flag it for the maintainers and the community.

No submissions yet.