Affinage

TRIM47

E3 ubiquitin-protein ligase TRIM47 · UniProt Q96LD4

Length
638 aa
Mass
69.5 kDa
Annotated
2026-06-10
100 papers in source corpus 29 papers cited in narrative 29 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TRIM47 is a RING-finger B-box coiled-coil (RBCC) E3 ubiquitin ligase that controls the abundance and activity of diverse substrate proteins to regulate inflammatory, oncogenic, and cytoprotective signaling (PMID:11511098, PMID:35513381). Its central biochemical activity is substrate-selective polyubiquitination with distinct chain-type outcomes: it catalyzes K48-linked ubiquitination that targets substrates for proteasomal degradation—including the tumor suppressors CYLD, BRCA1, CDO1, and the antiviral adaptor MAVS—and K63- or K27-linked ubiquitination that instead stabilizes substrates such as TRAF2, PKC-ε/PKD3, PLK1, and vimentin (PMID:35513381, PMID:34433666, PMID:38614226, PMID:41460629, PMID:39117713, PMID:39584529, PMID:39516831). Across these substrates a recurring functional theme is amplification of NF-κB and MAPK signaling, achieved either by degrading negative regulators (IκBα, CYLD) or by stabilizing positive effectors (TRAF2, PKC-ε, PLK1) (PMID:35513381, PMID:34433666, PMID:37943731, PMID:41460629, PMID:39516831). In cancer contexts TRIM47 acts broadly as an oncogenic ligase, degrading SMAD4, FOXO1, FBP1, P53, and BRCA1 to drive proliferation, invasion, glycolytic reprogramming, and therapy resistance (PMID:30979374, PMID:33408486, PMID:33529753, PMID:33622324, PMID:36906594). In the cerebrovascular endothelium TRIM47 maintains blood-brain barrier integrity through two activities: it inhibits autophagy by binding LC3B and restraining ULK1 activation, and it binds KEAP1 to stabilize NRF2 and sustain the antioxidant response, with endothelial-specific knockout causing BBB breakdown, astrogliosis, and cognitive impairment (PMID:39331575, PMID:41667829). In hematopoietic stem cells it degrades MAVS to restrain excessive innate immune activation and preserve stem cell function under stress (PMID:39117713). TRIM47 activity is itself controlled post-translationally: CARM1-mediated arginine methylation protects it from CRL4-CRBN-driven degradation, and ZDHHC21-mediated palmitoylation at C520 licenses its degradation of ATG16L1 (PMID:39567506, PMID:41342563).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2001 Low

    Established TRIM47 as a novel RBCC/RING-finger protein and first linked its overexpression to tumor tissue, framing it as a potential nuclear-acting regulator.

    Evidence SAGE profiling, Northern blot, and immunohistochemistry in astrocytoma showing nuclear localization and two LXXLL motifs

    PMID:11511098

    Open questions at the time
    • No catalytic activity or substrate demonstrated
    • Functional consequence of nuclear localization untested
    • Relevance of LXXLL/nuclear-receptor binding never validated
  2. 2019 Medium

    Demonstrated TRIM47's E3-ligase function for the first time by showing it ubiquitinates and degrades SMAD4 to drive a pro-tumor chemokine axis, defining it as a degradative ligase in cancer.

    Evidence Reciprocal Co-IP, ubiquitination assay, knockdown/overexpression, and xenografts in colorectal cancer cells

    PMID:30979374

    Open questions at the time
    • Ubiquitin chain linkage type not defined
    • RING-domain dependence of catalysis not formally tested
  3. 2019 Low

    Implicated TRIM47 in ischemic injury and NF-κB-driven inflammation in vivo, broadening its role beyond cancer.

    Evidence Trim47 knockdown/overexpression in rat MCAO and in vitro OGD models with Western blot readouts

    PMID:31178138

    Open questions at the time
    • No direct substrate identified for the NF-κB effect
    • Mechanism of pathway engagement inferred from phenotype only
  4. 2020 Medium

    Extended the degradative-ligase paradigm to additional tumor suppressors and a phosphatase, showing TRIM47 degrades FOXO1 and ubiquitinates PPM1A to sustain growth and fibrotic TGF-β/Smad signaling.

    Evidence Co-IP and ubiquitination assays in glioma cells (FOXO1) and lung fibroblasts (PPM1A), with functional and Wnt/β-catenin pathway readouts

    PMID:32502539 PMID:32603762 PMID:33408486

    Open questions at the time
    • Chain-type specificity not resolved
    • Wnt/β-catenin placement rests on pharmacological rescue only
  5. 2021 High

    Defined chain-type-specific, non-degradative ubiquitination as a distinct TRIM47 output, showing K63-linked TRAF2 and K27-linked PKC-ε ubiquitination that activate NF-κB/MAPK rather than triggering degradation.

    Evidence Linkage-specific (K63, K27) ubiquitination assays, reciprocal Co-IP, ternary-complex mapping, knockout mice, and drug-resistance assays in endothelial and breast cancer cells

    PMID:34433666 PMID:35513381

    Open questions at the time
    • Structural basis for chain-linkage selectivity unknown
    • What determines degradative vs stabilizing outcome on a given substrate not defined
  6. 2021 Medium

    Connected TRIM47 to metabolic reprogramming and p53 control, degrading FBP1 to drive the Warburg effect and degrading P53 in renal carcinoma.

    Evidence Co-IP, ubiquitination, and rescue assays in pancreatic and renal cancer cells with xenografts

    PMID:33529753 PMID:33622324

    Open questions at the time
    • Chain linkage not specified for either substrate
    • Direct vs indirect P53 regulation versus MDM2 axis not reconciled
  7. 2022 Medium

    Identified neuronal and cerebrovascular roles, showing activity-dependent TRIM47 restrains excitatory synapse formation and regulates brain endothelial permeability.

    Evidence Knockdown in rat hippocampal neurons with NMDAR pharmacology and spine quantification; siRNA in human brain endothelial cells with permeability assays

    PMID:35511193 PMID:36203070 PMID:36211980

    Open questions at the time
    • Synaptic substrate of TRIM47 not identified
    • Mechanism linking TRIM47 to endothelial permeability not yet molecular in these studies
  8. 2023 Medium

    Reinforced TRIM47 as a degrader of DNA-repair and inflammatory checkpoints, degrading BRCA1 (conferring PARP-inhibitor sensitivity) and IκBα (activating NF-κB under methionine signaling).

    Evidence Co-IP, ubiquitination, and rescue assays in triple-negative breast and gastric cancer cells with in vivo models

    PMID:36906594 PMID:37943731

    Open questions at the time
    • BRCA1 chain linkage not defined
    • Upstream control of TRIM47 by methionine not mechanistically resolved
  9. 2024 Medium

    Mapped substrate recognition and chain-type logic in detail, showing B30.2-domain-dependent K48 degradation of CDO1 (suppressing ferroptosis), K48 degradation of CYLD, and contrasting K63-linked stabilization of PLK1 and vimentin.

    Evidence Domain-deletion and linkage-specific (K48, K63) ubiquitination assays, Co-IP, yeast two-hybrid, and affinity pulldowns across hepatocellular, gastric, and head/neck cancer cells

    PMID:38614226 PMID:39516831 PMID:39584529 PMID:41460629

    Open questions at the time
    • General rules dictating K48 vs K63 outcome per substrate remain undefined
    • Structural model of B30.2 substrate binding absent
  10. 2024 High

    Established TRIM47 as a restraint on innate immunity and identified its post-translational regulation, degrading MAVS in HSCs and being itself stabilized by CARM1 methylation against CRL4-CRBN.

    Evidence K48-linkage ubiquitination assays, knockout mouse HSC functional assays, and methylation-site mutagenesis with CRL4-CRBN interaction assays

    PMID:39117713 PMID:39567506

    Open questions at the time
    • How TRIM47 toggles between immune-restraint and pro-inflammatory roles in different tissues unresolved
    • Triggers controlling CARM1 methylation of TRIM47 unknown
  11. 2024 Medium

    Defined autophagy regulation and lipid-based control of TRIM47, showing it inhibits autophagy by binding LC3B/restraining ULK1 and by ZDHHC21-mediated palmitoylation that drives ATG16L1 degradation.

    Evidence Imaging of LC3B binding and ULK1 phosphorylation assays in brain endothelial cells; acyl-biotin exchange, site-specific C520 mutant, and CLP/LPS sepsis models

    PMID:39331575 PMID:41342563

    Open questions at the time
    • LC3B LIR binding is computationally predicted, not biochemically mapped
    • Whether autophagy inhibition is ligase-dependent or adaptor-based unclear
  12. 2024 Medium

    Revealed exceptions to the degradation paradigm and disease-variant relevance, showing TRIM47 stabilizes SNAI1, degrades XAF1, binds MDM2, and that an ADAM17 disease variant alters TRIM47-mediated ADAM17 turnover affecting Notch and hair-follicle stem cells.

    Evidence Co-IP, ubiquitination, rescue assays, and an Adam17(p.D647N) knockin mouse model across HCC, head/neck cancer, and prostate cancer

    PMID:38771644 PMID:38802602 PMID:39567506 PMID:39834862

    Open questions at the time
    • Mechanism of MDM2/p53 modulation by TRIM47 not elucidated
    • How TRIM47 stabilizes some substrates while degrading others remains unexplained
  13. 2026 High

    Tied TRIM47's cerebrovascular function to a defined molecular pathway, showing endothelial TRIM47 binds KEAP1 to stabilize NRF2 and maintain BBB integrity, with NRF2 activation rescuing knockout phenotypes.

    Evidence Global and inducible endothelial-specific knockout mice, KEAP1 Co-IP, NRF2 analysis, and tBHQ rescue with cognitive/permeability readouts

    PMID:41667829

    Open questions at the time
    • Whether KEAP1 binding involves ubiquitination is not defined
    • Relationship between the autophagy-inhibitory and NRF2-stabilizing endothelial functions unresolved
  14. 2025 Medium

    Uncovered an antiviral, deubiquitination-promoting activity, showing TRIM47 restricts murine norovirus strain CR6 by promoting deubiquitination of viral NS1/2 rather than degradation.

    Evidence Forward genetic screen, overexpression, viral titer assays, and ubiquitination/deubiquitination assays of NS1/2 with strain comparison

    PMID:41251344

    Open questions at the time
    • How a ubiquitin ligase promotes deubiquitination is not mechanistically explained
    • Strain-specificity determinant (CR6 vs CW3) unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • The decisive open question is what governs TRIM47's substrate selection and ubiquitin chain-type choice, determining whether a given target is degraded, stabilized, or deubiquitinated across tissues.
  • No structural model of TRIM47 catalysis or B30.2 substrate engagement
  • No unifying determinant of degradative vs stabilizing vs deubiquitinating outcome
  • Tissue-specific cofactors directing substrate choice unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 7 GO:0140096 catalytic activity, acting on a protein 6 GO:0016874 ligase activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005829 cytosol 2 GO:0005634 nucleus 1
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-392499 Metabolism of proteins 5 R-HSA-168256 Immune System 3 R-HSA-1643685 Disease 2 R-HSA-8953897 Cellular responses to stimuli 2 R-HSA-9612973 Autophagy 2
Partners
BRCA1CDO1FBP1KEAP1MAVSPRKCESMAD4TRAF2
Complex memberships
TRIM47-PKCε-PKD3 ternary complex

Evidence

Reading pass · 29 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 GOA (TRIM47) was identified as a novel RING finger B-box coiled-coil (RBCC) protein overexpressed in astrocytoma, with prominent nuclear localization demonstrated by immunohistochemistry. It contains two LXXLL motifs thought to be important for nuclear receptor binding. SAGE expression profiling, Northern blot, immunohistochemistry, chromosomal localization Biochemical and biophysical research communications Low 11511098
2019 TRIM47 physically interacts with SMAD4 and promotes its ubiquitination and proteasomal degradation in colorectal cancer cells, leading to upregulation of CCL15 and activation of the CCL15-CCR1 signaling axis that drives tumor growth and invasion. Co-immunoprecipitation, Western blot, ubiquitination assay, TRIM47 knockdown/overexpression in CRC cells, xenograft mouse model Journal of experimental & clinical cancer research : CR Medium 30979374
2019 Trim47 knockdown in a rat model of cerebral ischemia-reperfusion injury reduced infarct size and suppressed apoptosis (inhibiting Caspase-3 cleavage) and inflammation (IL-6, TNF-α, iNOS) partly through blockage of NF-κB signaling. Genetic knockdown/overexpression in rat MCAO model, Western blot, in vitro OGD model Biochemical and biophysical research communications Low 31178138
2020 TRIM47 physically interacts with FOXO1 protein and promotes its ubiquitination and proteasomal degradation in glioma cells, thereby promoting glioma cell proliferation and progression. Co-immunoprecipitation (Co-IP), Western blot, ubiquitination assay, knockdown/knockout, xenograft mouse model OncoTargets and therapy Medium 33408486
2020 TRIM47 knockdown in glioma cells inhibited the Wnt/β-catenin signaling pathway and suppressed proliferation, migration, and invasion; activation of Wnt/β-catenin with LiCl reversed these inhibitory effects, placing TRIM47 upstream of this pathway. siRNA knockdown, Western blot, LiCl rescue experiment, xenograft mouse model Molecular and cellular probes Low 32603762
2020 TRIM47 overexpression induced ubiquitination of PPM1A (protein phosphatase magnesium-dependent 1A) and decreased its expression level in human embryonic lung fibroblasts, as shown by Co-immunoprecipitation; this led to sustained Smad2/3 phosphorylation and fibrotic phenotype. Co-immunoprecipitation, Western blot, lentiviral overexpression/RNAi, hydroxyproline assay Life sciences Medium 32502539
2021 TRIM47 promotes K63-linked ubiquitination of TRAF2 in vascular endothelial cells, activating NF-κB and MAPK signaling pathways and triggering inflammatory responses; TRIM47-deficient mice were resistant to LPS-induced acute lung injury. Co-immunoprecipitation, ubiquitination assay (K63-specific), TRIM47 knockdown/overexpression in endothelial cells, TRIM47-deficient mouse model, in vitro TNFα stimulation Signal transduction and targeted therapy High 35513381
2021 TRIM47 directly interacts with PKC-ε and PKD3 and promotes K27-linked polyubiquitination of PKC-ε, stabilizing PKC-ε and PKD3 in a ternary complex, thereby activating NF-κB signaling and conferring tamoxifen resistance in breast cancer cells. Co-immunoprecipitation, ubiquitination assay (K27-linkage specific), TRIM47 overexpression/knockdown, MCF-7 cell proliferation and resistance assays Proceedings of the National Academy of Sciences of the United States of America High 34433666
2021 TRIM47 directly binds to FBP1 (fructose-1,6-biphosphatase) and promotes its ubiquitination and degradation, thereby promoting aerobic glycolysis (Warburg effect) in pancreatic cancer cells; FBP1 overexpression abolished TRIM47-mediated Warburg effect. Co-immunoprecipitation, ubiquitination assay, TRIM47 knockdown/overexpression, FBP1 rescue experiment, in vitro and xenograft assays Pharmacological research Medium 33529753
2021 TRIM47 interacts with P53 protein and promotes its ubiquitination and proteasomal degradation in renal cell carcinoma, as demonstrated by mass spectrometry, Western blot, and immunoprecipitation assays. Mass spectrometry, immunoprecipitation, Western blot, ubiquitination assay, TRIM47 knockdown/overexpression, xenograft Cancer cell international Medium 33622324
2022 TRIM47 expression in hippocampal neurons is regulated by glutamate-induced synaptic activity requiring NMDA receptor activation. Knockdown of TRIM47 increases spine density and excitatory synapse development, identifying it as an activity-regulated E3 ligase that negatively regulates excitatory synapse formation. TRIM47 knockdown in cultured rat hippocampal neurons, object location test in vivo, spine density measurement, synapse quantification, NMDA receptor pharmacological inhibition Frontiers in molecular neuroscience Medium 36211980
2022 TRIM47 knockdown in glioma cells reduced human umbilical vein endothelial cell proliferation, migration, and tube formation (angiogenesis). Mechanistically, TRIM47 negatively regulates SMAD4 expression in glioma cells, and SMAD4 knockdown rescued the anti-angiogenic effects of TRIM47 silencing. siRNA knockdown, HUVEC functional assays (proliferation, migration, tube formation), SMAD4 knockdown rescue, xenograft vessel density In vitro cellular & developmental biology. Animal Low 36203070
2022 TRIM47 promotes endothelial permeability in brain endothelial cells; siRNA-mediated knockdown of TRIM47 in human brain endothelial cells increased endothelial permeability, identifying it as a candidate regulator of blood-brain barrier integrity relevant to cerebral small vessel disease. siRNA knockdown in human brain endothelial cells, endothelial permeability assay, immunohistochemistry for brain vessel enrichment Brain : a journal of neurology Low 35511193
2023 TRIM47 directly interacts with BRCA1 and promotes ubiquitin-ligase-mediated proteasomal degradation of BRCA1 in triple-negative breast cancer cells, reducing BRCA1 protein levels and downstream p53/p27/p21 expression; this confers sensitivity to PARP inhibitor olaparib. Co-immunoprecipitation, ubiquitination assay, TRIM47 overexpression/knockdown, BRCA1 rescue experiment, olaparib sensitivity assay in vitro and xenograft Oncogenesis Medium 36906594
2023 TRIM47 interacts with IκBα protein and promotes its ubiquitination and degradation; methionine restriction decreased TRIM47 expression, reduced IκBα ubiquitination, increased IκBα protein stability, and blocked nuclear p65 translocation and gastric cancer cell migration/invasion. TRIM47 overexpression reversed these effects. Co-immunoprecipitation, ubiquitination assay, protein stability assay (cycloheximide chase implied), Western blot, methionine restriction model, in vivo metastasis model Biological chemistry Medium 37943731
2024 TRIM47 interacts with CDO1 through its B30.2 domain and promotes K48-linked ubiquitination and proteasomal degradation of CDO1 in hepatocellular carcinoma cells, thereby reducing GSH synthesis and suppressing ferroptotic cell death. Co-immunoprecipitation, ubiquitination assay (K48-specific), domain deletion analysis (B30.2), CDO1 rescue experiment, ferroptosis assay Free radical biology & medicine Medium 38614226
2024 TRIM47 promotes HCC metastasis by interacting with SNAI1 and inhibiting its proteasomal degradation. Additionally, TRIM47 protein stability itself is regulated by CARM1-mediated arginine di-methylation at R210 and R582, which protects TRIM47 from ubiquitination and degradation by the E3 ubiquitin ligase complex CRL4CRBN. Co-immunoprecipitation, methylation site mutagenesis, ubiquitination assay, CARM1 knockdown/inhibition, CRL4CRBN complex interaction assay, in vitro and in vivo invasion assays Cell death discovery Medium 39567506
2024 TRIM47 promotes K63-linked ubiquitination and stabilization of PLK1 (polo-like kinase 1) in liver cancer cells, activating NF-κB and MAPK pathways and driving cell cycle progression; pharmacological PLK1 inhibition abrogated TRIM47-driven tumor growth. Yeast two-hybrid screening, ubiquitination assay (K63-specific), TRIM47 knockdown/overexpression, PLK1 inhibitor rescue, xenograft model Cellular oncology (Dordrecht, Netherlands) Medium 41460629
2024 Trim47 promotes K48-linked ubiquitination and proteasomal degradation of MAVS (mitochondrial antiviral-signaling protein) in hematopoietic stem cells (HSCs), limiting excessive innate immune activation. Trim47 deficiency caused impaired HSC function and survival after 5-FU or irradiation stress. K48-linkage-specific ubiquitination assay, Co-immunoprecipitation, Trim47-knockout mouse model, HSC functional assays (5-FU treatment, irradiation), flow cytometry Nature communications High 39117713
2024 TRIM47 interacts with vimentin and promotes its K63-linked ubiquitination, stabilizing vimentin and thereby enhancing proliferation and metastasis of hypopharyngeal and laryngeal cancer cells in a vimentin-dependent manner. Tandem affinity chromatography, denatured Ni-NTA agarose pulldown, ubiquitination assay (K63-specific), in vitro and in vivo metastasis models Cancer science Medium 39584529
2024 TRIM47 interacts with CYLD protein and promotes its K48-linked ubiquitination and proteasomal degradation in gastric cancer cells, thereby activating the NF-κB pathway. Co-immunoprecipitation, ubiquitination assay (K48-specific), TRIM47 knockdown/overexpression, xenograft model Biology direct Medium 39516831
2024 TRIM47 interacts with XAF1 (XIAP-associated factor 1) and promotes its ubiquitination and degradation in head and neck squamous cell carcinoma cells, suppressing apoptosis and autophagy; XAF1 overexpression reversed TRIM47-mediated proliferation promotion. Co-immunoprecipitation, ubiquitination assay, XAF1 rescue experiment, apoptosis/autophagy assays, xenograft model iScience Medium 39834862
2024 TRIM47 binds directly to ADAM17 and promotes its ubiquitination and degradation; a disease-causing ADAM17 variant (p.D647N) enhanced the ADAM17-TRIM47 association, increasing ADAM17 protein ubiquitination and degradation, reducing Notch signaling, and impairing hair follicle stem cell activation. Co-immunoprecipitation, ubiquitination assay, Adam17(p.D647N) knockin mouse model, HFSC functional assays, Notch pathway analysis JCI insight Medium 38771644
2024 TRIM47 is an endogenous inhibitor of autophagy in brain endothelial cells; it binds LC3B at the LIR motif (shown by in silico prediction and immunocytochemistry/super-resolution microscopy). Silencing Trim47 in mouse brain endothelial cells significantly increased autophagy with ULK1 phosphorylation and vacuole formation. In silico binding simulation, immunocytochemistry, super-resolution microscopy, Trim47 siRNA knockdown, ULK1 phosphorylation assay, autophagy induction pharmacology FASEB journal : official publication of the Federation of American Societies for Experimental Biology Medium 39331575
2024 Palmitoylation of TRIM47 at C520 (mediated by ZDHHC21) promotes ubiquitination and degradation of ATG16L1, thereby inhibiting autophagy and exacerbating sepsis-induced acute respiratory distress syndrome. Acyl-biotin exchange (ABE) assay for palmitoylation, Co-immunoprecipitation, ubiquitination assay, site-specific mutant (C520), CLP/LPS in vivo models, transmission electron microscopy FASEB journal : official publication of the Federation of American Societies for Experimental Biology Medium 41342563
2024 TRIM47 promotes K48-linked ubiquitination and proteasomal degradation of PPM1A in paclitaxel-resistant ovarian cancer cells, sustaining TGF-β signaling and chemoresistance; METTL3-mediated m6A modification enhances TRIM47 mRNA stability. Co-immunoprecipitation, GST pull-down, cycloheximide chase assay, ubiquitination assay, RNA immunoprecipitation (RIP), dual-luciferase assay, xenograft model American journal of reproductive immunology (New York, N.Y. : 1989) Medium 40435048
2024 TRIM47 binds to MDM2 (shown by Co-IP and GST pull-down assay) and regulates MDM2/p53 signaling in prostate cancer cells; MDM2 overexpression counteracted the effects of TRIM47 knockdown on cell viability, cycle, and apoptosis. Co-immunoprecipitation, GST pull-down assay, MDM2 overexpression rescue, cell viability, apoptosis assays Cell biochemistry and biophysics Low 38802602
2025 TRIM47 acts as a host restriction factor against murine norovirus (MNV) strain CR6 by promoting deubiquitination of the viral NS1/2 precursor protein (rather than ubiquitination/degradation), inhibiting an early stage of the MNV-CR6 life cycle in a strain-dependent manner; the closely related strain CW3 is not restricted. Forward genetic screen, TRIM47 overexpression in cell culture, viral titer assay, ubiquitination/deubiquitination assay of NS1/2, viral strain comparison Journal of virology Medium 41251344
2026 Endothelial TRIM47 maintains blood-brain barrier integrity by binding to KEAP1 and stabilizing NRF2 protein levels, promoting the NRF2 antioxidant pathway. Trim47-deficient mice and inducible endothelial-specific Trim47 knockout mice show cognitive impairments, increased BBB permeability, and astrogliosis; NRF2 activator treatment rescued these phenotypes. Trim47 knockout and inducible endothelial-specific knockout mouse models, BBB permeability assays, cognitive testing, KEAP1-TRIM47 Co-immunoprecipitation, NRF2 protein level analysis, pharmacological NRF2 activation rescue (tBHQ), human proteomic data analysis Communications biology High 41667829

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 The Gene Ontology Annotation (GOA) Database: sharing knowledge in Uniprot with Gene Ontology. Nucleic acids research 599 14681408
2014 The GOA database: gene Ontology annotation updates for 2015. Nucleic acids research 455 25378336
2008 The GOA database in 2009--an integrated Gene Ontology Annotation resource. Nucleic acids research 417 18957448
2003 The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Genome research 244 12654719
2000 A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans. Genetics 107 11102364
2005 An evaluation of GO annotation retrieval for BioCreAtIvE and GOA. BMC bioinformatics 104 15960829
2022 TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2. Signal transduction and targeted therapy 102 35513381
2019 TRIM47 is up-regulated in colorectal cancer, promoting ubiquitination and degradation of SMAD4. Journal of experimental & clinical cancer research : CR 91 30979374
2021 TRIM47 activates NF-κB signaling via PKC-ε/PKD3 stabilization and contributes to endocrine therapy resistance in breast cancer. Proceedings of the National Academy of Sciences of the United States of America 60 34433666
2006 LET-99, GOA-1/GPA-16, and GPR-1/2 are required for aster-positioned cytokinesis. Current biology : CB 60 17189697
2020 Knockdown of TRIM47 inhibits breast cancer tumorigenesis and progression through the inactivation of PI3K/Akt pathway. Chemico-biological interactions 44 31981573
2021 TRIM47 accelerates aerobic glycolysis and tumor progression through regulating ubiquitination of FBP1 in pancreatic cancer. Pharmacological research 42 33529753
2019 Trim47 is a critical regulator of cerebral ischemia-reperfusion injury through regulating apoptosis and inflammation. Biochemical and biophysical research communications 42 31178138
2021 TRIM47 promotes malignant progression of renal cell carcinoma by degrading P53 through ubiquitination. Cancer cell international 37 33622324
2017 Occupational exposure of cashew nut workers to Kyasanur Forest disease in Goa, India. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 35 28627428
2019 Peer supervision for assuring the quality of non-specialist provider delivered psychological intervention: Lessons from a trial for perinatal depression in Goa, India. Behaviour research and therapy 34 31870496
2005 Thraustochytrium gaertnerium sp. nov.: a new thraustochytrid stramenopilan protist from mangroves of Goa, India. Protist 33 16325543
2017 A study of harmful drug-drug interactions due to polypharmacy in hospitalized patients in Goa Medical College. Perspectives in clinical research 32 29109936
2022 Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate. Brain : a journal of neurology 27 35511193
2013 Marine actinobacteria showing phosphate-solubilizing efficiency in Chorao Island, Goa, India. Current microbiology 27 23288302
2001 GOA, a novel gene encoding a ring finger B-box coiled-coil protein, is overexpressed in astrocytoma. Biochemical and biophysical research communications 27 11511098
2010 Denitrification: an important pathway for nitrous oxide production in tropical mangrove sediments (Goa, India). Journal of environmental quality 26 20830937
2005 Marichromatium indicum sp. nov., a novel purple sulfur gammaproteobacterium from mangrove soil of Goa, India. International journal of systematic and evolutionary microbiology 25 15774642
2020 TRIM47 Promotes the Development of Glioma by Ubiquitination and Degradation of FOXO1. OncoTargets and therapy 23 33408486
2020 Knockdown of TRIM47 inhibits glioma cell proliferation, migration and invasion through the inactivation of Wnt/β-catenin pathway. Molecular and cellular probes 22 32603762
2020 Anti-fibrotic effect of melittin on TRIM47 expression in human embryonic lung fibroblast through regulating TRIM47 pathway. Life sciences 21 32502539
1979 Purification of human intestinal goblet cell antigen (GOA), its immunohistological demonstration in the intestine and in mucus producing gastrointestinal adenocarcinomas. Virchows Archiv. A, Pathological anatomy and histology 21 157605
2021 Presynaptic Gαo (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans. Genetics 20 34037773
2010 The G protein regulators EGL-10 and EAT-16, the Giα GOA-1 and the G(q)α EGL-30 modulate the response of the C. elegans ASH polymodal nociceptive sensory neurons to repellents. BMC biology 20 21070627
2020 Autograft cellular composition and outcome in NHL patients: results of the prospective multicenter GOA study. Leukemia & lymphoma 19 32419549
2017 Characterization and biological function analysis of the TRIM47 gene from common carp (Cyprinus carpio). Gene 19 28629823
2021 Autograft cellular composition and outcome in myeloma patients: Results of the prospective multicenter GOA study. Transfusion 16 33955591
2008 Evaluation of impairment of DNA integrity in marine gastropods (Cronia contracta) as a biomarker of genotoxic contaminants in coastal water around Goa, West coast of India. Ecotoxicology and environmental safety 15 18358533
2004 Resting behavior and malaria vector incrimination of Anopheles stephensi in Goa, India. Journal of the American Mosquito Control Association 15 15532935
2024 TRIM47-CDO1 axis dictates hepatocellular carcinoma progression by modulating ferroptotic cell death through the ubiquitin‒proteasome system. Free radical biology & medicine 13 38614226
2020 Serological evidence of Japanese encephalitis virus infection in pigs in a low human incidence state, Goa, India. Preventive veterinary medicine 13 31945550
2005 Who tangos with GOA?-Use of Gene Ontology Annotation (GOA) for biological interpretation of '-omics' data and for validation of automatic annotation tools. In silico biology 13 15972001
1992 Rat pineal Gsa, Gia and Goa: relative abundance and development. Brain research 13 1611517
2023 Overexpression of tripartite motif-containing 47 (TRIM47) confers sensitivity to PARP inhibition via ubiquitylation of BRCA1 in triple negative breast cancer cells. Oncogenesis 12 36906594
2016 Pathways to HIV testing and care in Goa, India: exploring psychosocial barriers and facilitators using mixed methods. BMC public health 12 27516106
1996 Clinical trials of a new immunochromatographic test for diagnosis of Plasmodium falciparum malaria in Goa. Indian journal of malariology 12 9125830
2024 TRIM47 drives gastric cancer cell proliferation and invasion by regulating CYLD protein stability. Biology direct 11 39516831
2022 TRIM47 promotes ovarian cancer cell proliferation, migration, and invasion by activating STAT3 signaling. Clinics (Sao Paulo, Brazil) 11 36288633
2020 Mobilization characteristics, blood graft composition, and outcome in diffuse large B-cell lymphoma after autologous stem cell transplantation: Results from the prospective multicenter GOA study. Transfusion 11 33245582
2012 Agromyces indicus sp. nov., isolated from mangroves sediment in Chorao Island, Goa, India. Antonie van Leeuwenhoek 11 22569993
2022 Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers. Cells 10 35954308
2018 Phylogenetic characterization of culturable bacteria and fungi associated with tarballs from Betul beach, Goa, India. Marine pollution bulletin 10 29571411
2011 Isolation and Confirmation of Listeria Species from Seafood off Goa Region by Polymerase Chain Reaction. Indian journal of microbiology 10 22282604
2000 G(i1) and G(oA) differentially determine kinetic efficacies of agonists for kappa-opioid receptor. FEBS letters 10 10802068
2024 IDSL.GOA: gene ontology analysis for interpreting metabolomic datasets. Scientific reports 9 38221536
2020 CD34+ cell mobilization, blood graft composition, and posttransplant recovery in myeloma patients compared to non-Hodgkin's lymphoma patients: results of the prospective multicenter GOA study. Transfusion 9 32333404
2019 Metagenomic analysis of tarball-associated bacteria from Goa, India. Marine pollution bulletin 9 30955749
2019 Haloferax sulfurifontis GUMFAZ2 producing xylanase-free cellulase retrieved from Haliclona sp. inhabiting rocky shore of Anjuna, Goa-India. Journal of basic microbiology 9 30980726
2015 Promising Biological Indicator of Heavy Metal Pollution: Bioluminescent Bacterial Strains Isolated and Characterized from Marine Niches of Goa, India. Indian journal of microbiology 8 26063943
1978 Alcian blue staining intestinal goblet cell antigen (GOA): a marker for gastric signet ring cell and colonic colloidal carcinoma. Klinische Wochenschrift 8 213641
2024 TRIM47 promotes HDM-induced bronchial epithelial pyroptosis by regulating NEMO ubiquitination to activate NF-κB/NLRP3 signaling. Cell biology international 7 38769645
2024 Trim47 prevents hematopoietic stem cell exhaustion during stress by regulating MAVS-mediated innate immune pathway. Nature communications 7 39117713
2024 Arginine methylation-dependent TRIM47 stability mediated by CARM1 promotes the metastasis of hepatocellular carcinoma. Cell death discovery 7 39567506
2023 Methionine restriction attenuates the migration and invasion of gastric cancer cells by inhibiting nuclear p65 translocation through TRIM47. Biological chemistry 7 37943731
2022 TRIM47 promotes glioma angiogenesis by suppressing Smad4. In vitro cellular & developmental biology. Animal 7 36203070
2022 Activity-regulated E3 ubiquitin ligase TRIM47 modulates excitatory synapse development. Frontiers in molecular neuroscience 7 36211980
2016 Assessment of mangroves from Goa, west coast India using DNA barcode. SpringerPlus 7 27652127
2024 White matter hyperintensity genetic risk factor TRIM47 regulates autophagy in brain endothelial cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 6 39331575
2022 Impact of the number of cryopreserved CD34+ cells in the infused blood grafts on hematologic recovery and survival in myeloma patients after autologous stem cell transplantation: Experience from the GOA study. Journal of clinical apheresis 6 36239392
2020 Variation in phytoplankton community and its implication to dimethylsulphide production at a coastal station off Goa, India. Marine environmental research 6 32275508
2019 High abundance of Vibrio in tarball-contaminated seawater from Vagator beach, Goa, India. Marine pollution bulletin 6 31796236
2013 A G-protein α subunit, GOA-1, plays a role in C. elegans avoidance behavior of strongly alkaline pH. Communicative & integrative biology 6 24563709
2011 Under-nutrition among adolescents: a survey in five secondary schools in rural Goa. The National medical journal of India 6 21608350
2019 Sex-specific regulation of neuronal functions in Caenorhabditis elegans: the sex-determining protein TRA-1 represses goa-1/Gα(i/o). Molecular genetics and genomics : MGG 5 31776761
2013 A novel strategy for cell-autonomous gene knockdown in Caenorhabditis elegans defines a cell-specific function for the G-protein subunit GOA-1. Genetics 5 23525334
2006 Opioid receptor-like (ORL1) receptor utilizes both G(oA) and G(oB) for signal transduction. Protein and peptide letters 5 16800795
2024 TRIM47 promotes hypopharyngeal and laryngeal cancers progression through promoting K63-linked ubiquitination of vimentin. Cancer science 4 39584529
2023 Knocking down Trim47 ameliorated sevoflurane-induced neuronal cell injury and cognitive impairment in rats. Experimental brain research 4 37067562
2020 Optical characteristics of colored dissolved organic matter during blooms of Trichodesmium in the coastal waters off Goa. Environmental monitoring and assessment 4 32676790
2020 Genotypic determination of human group A rotaviruses from Goa and Meghalaya states, India. Heliyon 4 32904180
2016 Horizontal gene transfer versus biostimulation: A strategy for bioremediation in Goa. Marine pollution bulletin 4 28029340
2008 Sampling of adult mosquito vectors with Mosquito Magnet Pro in Panaji, Goa, India. Journal of the American Mosquito Control Association 4 19181075
2025 Driving aspects of microplastic uptake: Influence in the Bentho-Pelagic ecosystem and its associated ecological risks along the coast of Goa, India. Environmental research 3 40233846
2024 ADAM17 variant causes hair loss via ubiquitin ligase TRIM47-mediated degradation. JCI insight 3 38771644
2024 TRIM47 inhibits cisplatin chemosensitivity and endoplasmic reticulum stress-induced apoptosis of ovarian cancer cells. Molecular and cellular probes 3 39096978
2024 TRIM47 promotes head and neck squamous cell carcinoma malignant progression by degrading XAF1 through ubiquitination. iScience 3 39834862
2019 Clinical Spectrum and Complications of Polycythemia, in Patients presenting at Tertiary Care Centre at Goa. The Journal of the Association of Physicians of India 3 31571446
2014 Prevalence and genetic profiles of Escherichia coli from mangroves and mangrove associated foods off Goa, India. Marine pollution bulletin 3 25001886
2006 Activation of nematode G protein GOA-1 by the human muscarinic acetylcholine receptor M2 subtype. Functional coupling of G-protein-coupled receptor and G protein originated from evolutionarily distant animals. The FEBS journal 3 17087737
2025 Knockdown of TRIM47 Overcomes Paclitaxel Resistance in Ovarian Cancer by Suppressing the TGF-β Pathway via PPM1A. American journal of reproductive immunology (New York, N.Y. : 1989) 2 40435048
2025 Grass carp Trim47 restricts GCRV infection via SPRY domain-mediated autophagic degradation of nonstructural proteins and disruption of viral inclusion bodies. Frontiers in immunology 2 40709172
2025 GOA-1 regulates spermathecal transits. microPublication biology 2 41306678
2024 IDSL.GOA: Gene Ontology Analysis for Interpreting Metabolomic datasets. bioRxiv : the preprint server for biology 2 37034715
2024 TRIM47 promotes the Warburg effect and reduces ferroptosis in prostate cancer by FBP1 and FOXO1. Translational andrology and urology 2 39434735
2026 Endothelial TRIM47 regulates blood-brain barrier integrity and cognition via the KEAP1/NRF2 signalling pathway in mice. Communications biology 1 41667829
2025 Improved GOA-based fuzzy PI speed control of PMSM with predictive current regulation. PloS one 1 39883794
2025 Key Roles of TRPV Channels Hg-osm-9, Hg-ocr-2, and G-Protein α Subunit Hg-goa-1 in the Chemosensory Behavior and Parasitism of Heterodera Glycines. Journal of agricultural and food chemistry 1 41122996
2024 White matter hyperintensity genetic risk factor TRIM47 regulates autophagy in brain endothelial cells. bioRxiv : the preprint server for biology 1 38187529
2024 TRIM47 silencing inhibits the malignant biological behaviors of prostate cancer cells by regulating MDM2/p53 signaling. Cell biochemistry and biophysics 1 38802602
2023 Bacterial diversity and community structure of salt pans from Goa, India. Frontiers in microbiology 1 38111647
2011 Distribution of diatom Pseudo-nitzschia and dinoflagellates of Dinophysis spp along coast off Goa. Journal of environmental biology 1 21888234
2025 TRIM47 Facilitates Osteosarcoma Progression via Destabilising FBP1 and Thus Activation of Wnt/β-Catenin Pathway. Journal of cellular and molecular medicine 0 40801794
2025 TRIM47 inhibits murine norovirus replication in a strain-dependent manner. Journal of virology 0 41251344
2025 Palmitoylation of TRIM47 Regulates ATG16L1-Mediated Autophagy to Exacerbate Respiratory Distress Syndrome in Sepsis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 0 41342563
2025 TRIM47-facilitated PLK1 stabilization promotes the proliferation of liver cancer cells. Cellular oncology (Dordrecht, Netherlands) 0 41460629

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