Affinage

TOR1B

Torsin-1B · UniProt O14657

Length
336 aa
Mass
38.0 kDa
Annotated
2026-06-10
8 papers in source corpus 1 papers cited in narrative 1 extracted findings
Cross-family judge vs UniProt: UniProt preferred faithfulness: 1/1 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TOR1B localizes to the nucleus and endoplasmic reticulum in breast cancer cells (PMID:36707670). Beyond this localization observation, no enzymatic activity, binding partners, or pathway mechanism has been characterized in the available corpus.

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2023 Low

    Established where TOR1B protein resides in cancer cells, providing a first compartmental clue to its cellular role.

    Evidence Subcellular localization assay (immunofluorescence/fractionation) in breast cancer cell lines

    PMID:36707670

    Open questions at the time
    • Single lab, single method reported briefly with no functional consequence linked to the observed localization
    • No binding partners or molecular activity identified
    • No pathway or process role established

Open questions

Synthesis pass · forward-looking unresolved questions
  • The molecular function, substrates, interaction partners, and pathway context of TOR1B remain undefined.
  • No enzymatic or biochemical activity demonstrated
  • No direct physical partners identified
  • No mechanistic link between localization and any cellular process

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
No controlled-vocabulary terms were assigned to this entry.

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2023 TOR1B protein was found to localize to the nucleus and endoplasmic reticulum in cancer cells, as determined by subcellular localization experiments in breast cancer cell lines. Subcellular localization assay in cancer cells (immunofluorescence/fractionation) Scientific reports Low 36707670

Source papers

Stage 0 corpus · 8 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1994 Self-peptides bound to the type I diabetes associated class II MHC molecules HLA-DQ1 and HLA-DQ8. International immunology 75 7865457
2021 A novel Trichoderma asperellum strain DQ-1 promotes tomato growth and induces resistance to gray mold caused by Botrytis cinerea. FEMS microbiology letters 17 34751779
2002 B and C hepatitis viruses, HLA-DQ1 and -DR3 alleles and autoimmunity in patients with hepatocellular carcinoma. Journal of hepatology 12 11943424
1995 HLA-DQ1 is associated with clinical response and survival of patients with melanoma who are treated with interleukin-2. Therapeutic immunology 11 7553066
2023 TOR1B: a predictor of bone metastasis in breast cancer patients. Scientific reports 5 36707670
1993 A human monoclonal antibody reacting against HLA-DQ1-, DQ4-, and a subset of DQ7-bearing cells. Human immunology 1 7681815
2026 A novel HN-AD strain Paenibacillus glycanilyticus DQ-1 with high-efficiency nitrogen removal capacity: genomic insights into its nitrogen metabolic mechanism. BMC microbiology 0 42157074
2004 [Analysis of the association of HLA-DQ1 alleles with mutation of the 21-hydroxylase gene in patients with congenital adrenal hyperplasia]. Genetika 0 15027205

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