{"gene":"TOR1B","run_date":"2026-06-10T10:51:55","timeline":{"discoveries":[{"year":2023,"finding":"TOR1B protein was found to localize to the nucleus and endoplasmic reticulum in cancer cells, as determined by subcellular localization experiments in breast cancer cell lines.","method":"Subcellular localization assay in cancer cells (immunofluorescence/fractionation)","journal":"Scientific reports","confidence":"Low","confidence_rationale":"Tier 3 / Weak — single lab, single method described briefly in abstract with no functional consequence linked to localization","pmids":["36707670"],"is_preprint":false}],"current_model":"TOR1B protein localizes to the nucleus and endoplasmic reticulum in cancer cells; no direct enzymatic activity, binding partners, or pathway mechanism has been established in the available literature."},"narrative":{"mechanistic_narrative":"TOR1B localizes to the nucleus and endoplasmic reticulum in breast cancer cells [PMID:36707670]. Beyond this localization observation, no enzymatic activity, binding partners, or pathway mechanism has been characterized in the available corpus.","teleology":[{"year":2023,"claim":"Established where TOR1B protein resides in cancer cells, providing a first compartmental clue to its cellular role.","evidence":"Subcellular localization assay (immunofluorescence/fractionation) in breast cancer cell lines","pmids":["36707670"],"confidence":"Low","gaps":["Single lab, single method reported briefly with no functional consequence linked to the observed localization","No binding partners or molecular activity identified","No pathway or process role established"]},{"year":null,"claim":"The molecular function, substrates, interaction partners, and pathway context of TOR1B remain undefined.","evidence":"","pmids":[],"confidence":"Low","gaps":["No enzymatic or biochemical activity demonstrated","No direct physical partners identified","No mechanistic link between localization and any cellular process"]}],"mechanism_profile":{"molecular_activity":[],"localization":[],"pathway":[],"complexes":[],"partners":[],"other_free_text":[]}},"prefetch_data":{"uniprot":{"accession":"O14657","full_name":"Torsin-1B","aliases":["Torsin ATPase-1B","Torsin family 1 member B"],"length_aa":336,"mass_kda":38.0,"function":"May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues","subcellular_location":"Endoplasmic reticulum lumen; Nucleus membrane","url":"https://www.uniprot.org/uniprotkb/O14657/entry"},"depmap":{"release":"DepMap","has_data":true,"is_common_essential":false,"resolved_as":"","url":"https://depmap.org/portal/gene/TOR1B","classification":"Not Classified","n_dependent_lines":2,"n_total_lines":1208,"dependency_fraction":0.0016556291390728477},"opencell":{"profiled":false,"resolved_as":"","ensg_id":"","cell_line_id":"","localizations":[],"interactors":[{"gene":"CANX","stoichiometry":0.2}],"url":"https://opencell.sf.czbiohub.org/search/TOR1B","total_profiled":1310},"omim":[{"mim_id":"608050","title":"TORSIN 1B; TOR1B","url":"https://www.omim.org/entry/608050"},{"mim_id":"605204","title":"TORSIN 1A; TOR1A","url":"https://www.omim.org/entry/605204"},{"mim_id":"123812","title":"cAMP RESPONSE ELEMENT MODULATOR; CREM","url":"https://www.omim.org/entry/123812"}],"hpa":{"profiled":true,"resolved_as":"","reliability":"Uncertain","locations":[{"location":"Nuclear speckles","reliability":"Uncertain"},{"location":"Cytosol","reliability":"Additional"}],"tissue_specificity":"Low tissue specificity","tissue_distribution":"Detected in all","driving_tissues":[],"url":"https://www.proteinatlas.org/search/TOR1B"},"hgnc":{"alias_symbol":["DQ1","MGC4386"],"prev_symbol":[]},"alphafold":{"accession":"O14657","domains":[{"cath_id":"3.40.50.300","chopping":"64-275","consensus_level":"high","plddt":89.7946,"start":64,"end":275},{"cath_id":"-","chopping":"280-333","consensus_level":"high","plddt":94.1948,"start":280,"end":333}],"viewer_url":"https://alphafold.ebi.ac.uk/entry/O14657","model_url":"https://alphafold.ebi.ac.uk/files/AF-O14657-F1-model_v6.cif","pae_url":"https://alphafold.ebi.ac.uk/files/AF-O14657-F1-predicted_aligned_error_v6.png","plddt_mean":85.12},"mouse_models":{"mgi_url":"https://www.informatics.jax.org/marker/summary?nomen=TOR1B","jax_strain_url":"https://www.jax.org/strain/search?query=TOR1B"},"sequence":{"accession":"O14657","fasta_url":"https://rest.uniprot.org/uniprotkb/O14657.fasta","uniprot_url":"https://www.uniprot.org/uniprotkb/O14657/entry","alphafold_viewer_url":"https://alphafold.ebi.ac.uk/entry/O14657"}},"corpus_meta":[{"pmid":"7865457","id":"PMC_7865457","title":"Self-peptides bound to the type I diabetes associated class II MHC molecules HLA-DQ1 and HLA-DQ8.","date":"1994","source":"International immunology","url":"https://pubmed.ncbi.nlm.nih.gov/7865457","citation_count":75,"is_preprint":false},{"pmid":"34751779","id":"PMC_34751779","title":"A novel Trichoderma asperellum strain DQ-1 promotes tomato growth and induces resistance to gray mold caused by Botrytis cinerea.","date":"2021","source":"FEMS microbiology letters","url":"https://pubmed.ncbi.nlm.nih.gov/34751779","citation_count":17,"is_preprint":false},{"pmid":"11943424","id":"PMC_11943424","title":"B and C hepatitis viruses, HLA-DQ1 and -DR3 alleles and autoimmunity in patients with hepatocellular carcinoma.","date":"2002","source":"Journal of hepatology","url":"https://pubmed.ncbi.nlm.nih.gov/11943424","citation_count":12,"is_preprint":false},{"pmid":"7553066","id":"PMC_7553066","title":"HLA-DQ1 is associated with clinical response and survival of patients with melanoma who are treated with interleukin-2.","date":"1995","source":"Therapeutic immunology","url":"https://pubmed.ncbi.nlm.nih.gov/7553066","citation_count":11,"is_preprint":false},{"pmid":"36707670","id":"PMC_36707670","title":"TOR1B: a predictor of bone metastasis in breast cancer patients.","date":"2023","source":"Scientific reports","url":"https://pubmed.ncbi.nlm.nih.gov/36707670","citation_count":5,"is_preprint":false},{"pmid":"7681815","id":"PMC_7681815","title":"A human monoclonal antibody reacting against HLA-DQ1-, DQ4-, and a subset of DQ7-bearing cells.","date":"1993","source":"Human immunology","url":"https://pubmed.ncbi.nlm.nih.gov/7681815","citation_count":1,"is_preprint":false},{"pmid":"15027205","id":"PMC_15027205","title":"[Analysis of the association of HLA-DQ1 alleles with mutation of the 21-hydroxylase gene in patients with congenital adrenal hyperplasia].","date":"2004","source":"Genetika","url":"https://pubmed.ncbi.nlm.nih.gov/15027205","citation_count":0,"is_preprint":false},{"pmid":"42157074","id":"PMC_42157074","title":"A novel HN-AD strain Paenibacillus glycanilyticus DQ-1 with high-efficiency nitrogen removal capacity: genomic insights into its nitrogen metabolic mechanism.","date":"2026","source":"BMC microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/42157074","citation_count":0,"is_preprint":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":6154,"output_tokens":232,"usd":0.010971,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":6423,"output_tokens":533,"usd":0.02272,"stage2_stop_reason":"end_turn"},"total_usd":0.033691,"stage1_batch_id":"msgbatch_017qqVz33Ga63SCDwzb35XPb","stage2_batch_id":"msgbatch_01Scr2Ei9x4HJMiRGxwrmvLK","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2023,\n      \"finding\": \"TOR1B protein was found to localize to the nucleus and endoplasmic reticulum in cancer cells, as determined by subcellular localization experiments in breast cancer cell lines.\",\n      \"method\": \"Subcellular localization assay in cancer cells (immunofluorescence/fractionation)\",\n      \"journal\": \"Scientific reports\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — single lab, single method described briefly in abstract with no functional consequence linked to localization\",\n      \"pmids\": [\"36707670\"],\n      \"is_preprint\": false\n    }\n  ],\n  \"current_model\": \"TOR1B protein localizes to the nucleus and endoplasmic reticulum in cancer cells; no direct enzymatic activity, binding partners, or pathway mechanism has been established in the available literature.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"TOR1B localizes to the nucleus and endoplasmic reticulum in breast cancer cells [#0]. Beyond this localization observation, no enzymatic activity, binding partners, or pathway mechanism has been characterized in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2023,\n      \"claim\": \"Established where TOR1B protein resides in cancer cells, providing a first compartmental clue to its cellular role.\",\n      \"evidence\": \"Subcellular localization assay (immunofluorescence/fractionation) in breast cancer cell lines\",\n      \"pmids\": [\"36707670\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"Single lab, single method reported briefly with no functional consequence linked to the observed localization\",\n        \"No binding partners or molecular activity identified\",\n        \"No pathway or process role established\"\n      ]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"The molecular function, substrates, interaction partners, and pathway context of TOR1B remain undefined.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"No enzymatic or biochemical activity demonstrated\",\n        \"No direct physical partners identified\",\n        \"No mechanistic link between localization and any cellular process\"\n      ]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [],\n    \"localization\": [],\n    \"pathway\": [],\n    \"complexes\": [],\n    \"partners\": [],\n    \"other_free_text\": []\n  }\n}","audit_flag":null,"evaluation":{"pairwise":"loss","faith_supported":1,"faith_total":1,"faith_pct":100.0}}