Affinage

TNIP1

TNFAIP3-interacting protein 1 · UniProt Q15025

Length
636 aa
Mass
71.9 kDa
Annotated
2026-06-10
100 papers in source corpus 25 papers cited in narrative 25 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TNIP1 (ABIN-1) is a ubiquitin-sensing scaffold protein that restrains inflammatory and cell-death signaling and, through a distinct set of domains, modulates selective autophagy (PMID:19060883, PMID:29203883, PMID:36898370). As an NF-κB inhibitor it binds polyubiquitin chains and uses an ABIN homology domain (AHD2) genetically separable from its A20-binding activity to block NF-κB; it links A20 to NEMO/IKKγ to drive NEMO de-ubiquitination and additionally blocks processing of the p105 precursor to p50 (PMID:16684768, PMID:12586352, PMID:19695220). At the TNF receptor signaling complex it is recruited in a LUBAC/Met1-ubiquitin-dependent manner where it controls A20 recruitment and limits Lys63 ubiquitylation and activation of RIPK1, thereby preventing caspase-8/FADD-dependent apoptosis and licensing of necroptosis; loss of TNIP1 causes TNF-dependent embryonic lethality rescuable by TNF deficiency or RIPK1/RIPK3 inactivation (PMID:19060883, PMID:29203883, PMID:29930103). This cell-death-restraining role is partly synergistic with A20 in intestinal epithelium (PMID:29930103). In innate and adaptive immunity TNIP1 acts upstream of MyD88 in dendritic-cell TLR signaling and restrains IL-17-induced NF-κB programs in keratinocytes, with cell-type-specific loss producing psoriasis-like inflammation (PMID:23785118, PMID:27671649). TNIP1 is itself a node of feedback control: its expression is induced by NF-κB, PPARγ, and retinoic-acid receptors through defined promoter elements, and it acts as an atypical corepressor of agonist-bound RARs and PPARs via LXXLL/NR-box motifs (PMID:19732752, PMID:21967852, PMID:22001530, PMID:23228856). Beyond signaling, TNIP1 uses a conserved LIR motif that binds LC3/GABARAP and an AHD3 domain that binds TAX1BP1, and its phosphorylation-regulated association with FIP200 lets it compete with autophagy receptors to negatively regulate mitophagy; TBK1-driven, LIR-dependent autophagic degradation of TNIP1 permits initiation of inflammation (PMID:36574265, PMID:36898370, PMID:36440857). A disease-associated Q333P variant impairs TNIP1 recruitment to damaged mitochondria and MyD88/IRAK1 autophagosomal recruitment, amplifying TLR7-driven autoimmunity (PMID:39060650).

Mechanistic history

Synthesis pass · year-by-year structured walk · 19 steps
  1. 2003 Medium

    Established that TNIP1's NF-κB-inhibitory activity is structurally and functionally separable from its A20 interaction, defining the AHD2 domain as the effector module.

    Evidence Site-directed mutagenesis of the AHD2 region with NF-κB reporter and Co-IP assays

    PMID:12586352

    Open questions at the time
    • Molecular target through which AHD2 blocks NF-κB not defined
    • Single-lab functional mutagenesis
  2. 2006 Medium

    Showed how TNIP1 inhibits NF-κB mechanistically: it bridges A20 to NEMO/IKKγ to enable A20-dependent de-ubiquitination.

    Evidence Co-IP, siRNA knockdown, and NF-κB reporter assays

    PMID:16684768

    Open questions at the time
    • Stoichiometry of the A20-TNIP1-NEMO complex not resolved
    • In vivo relevance not tested here
  3. 2009 Medium

    Extended the NF-κB-inhibitory repertoire by showing TNIP1 blocks p105-to-p50 processing through a p105 interaction requiring AHD2.

    Evidence Co-IP, domain deletion, and NF-κB reporter assays

    PMID:19695220

    Open questions at the time
    • Mechanism of processing inhibition unresolved
    • Single-lab overexpression-based
  4. 2005 Medium

    Demonstrated an NF-κB-independent anti-apoptotic function in vivo distinct from IkBa, separating TNIP1's death-protective and transcriptional roles.

    Evidence Adenoviral TNIP1 transfer in a murine TNF/galactosamine liver-failure model with IkBa comparison

    PMID:16025521

    Open questions at the time
    • Molecular basis of the anti-apoptotic activity not defined at this stage
  5. 2008 High

    Defined TNIP1 as a polyubiquitin-binding protein essential for survival, linking ubiquitin sensing to suppression of caspase-8/FADD-driven apoptosis.

    Evidence Knockout mice with TNF-deficiency genetic rescue, biochemical ubiquitin-binding assays, and TNF signaling complex analysis

    PMID:19060883

    Open questions at the time
    • Ubiquitin chain-type specificity only partly defined
    • Did not address necroptosis arm
  6. 2017 High

    Resolved how TNIP1 restrains necroptosis: LUBAC/Met1-ubiquitin-dependent recruitment to the TNF-RSC positions it to control A20 recruitment and RIPK1 Lys63-ubiquitylation/activation.

    Evidence Knockout mice, TNF-RSC biochemistry, ubiquitylation assays, and RIPK1-kinase-inhibitor/RIPK3-deficiency rescue of lethality

    PMID:29203883

    Open questions at the time
    • Direct Met1-ubiquitin binding by TNIP1 vs indirect recruitment not fully separated
  7. 2018 High

    Showed A20 and TNIP1 act synergistically and partly redundantly to suppress TNF-induced epithelial cell death.

    Evidence IEC-specific A20/ABIN-1 double-knockout mice, enteroids, and RIPK1/RIPK3/caspase rescue experiments

    PMID:29930103

    Open questions at the time
    • Whether synergy reflects shared complex assembly not biochemically dissected
  8. 2013 High

    Placed TNIP1 genetically upstream of MyD88 in dendritic-cell TLR signaling, connecting its loss to IL-23 production and psoriasiform disease.

    Evidence CD11c-Cre conditional knockout with MyD88 epistasis and cytokine/flow analyses

    PMID:23785118

    Open questions at the time
    • Direct molecular target within MyD88 pathway not identified
  9. 2016 High

    Established keratinocytes as a cell-autonomous site of TNIP1 action restraining IL-17 signaling in psoriasis.

    Evidence Tissue-specific conditional knockout with in vitro IL-17 stimulation and in vivo inflammatory triggers

    PMID:27671649

    Open questions at the time
    • Molecular link between TNIP1 and IL-17 receptor signaling not mapped
  10. 2009 Medium

    Identified TNIP1 as an atypical RAR corepressor that binds liganded receptors via NR-box/LXXLL motifs yet competes with coactivators.

    Evidence Two-hybrid, Co-IP, RAR reporter assays, and domain mapping with SRC1 competition

    PMID:19732752

    Open questions at the time
    • Mechanism of repression at target promoters not defined
  11. 2011 Medium

    Generalized the corepressor role to agonist-bound PPARs and defined feedback wiring whereby NF-κB, PPARγ, and RARs transcriptionally control TNIP1.

    Evidence cDNA library two-hybrid, reporter assays, EMSA/ChIP of NF-κB/PPRE/RARE promoter elements, and skin localization studies

    PMID:21967852 PMID:22001530 PMID:22147607 PMID:23228856

    Open questions at the time
    • Physiological weight of corepressor vs cytoplasmic signaling roles unresolved
    • Endogenous occupancy in vivo not established
  12. 2018 Medium

    Showed dose-sensitive and infection-context regulation of TNIP1, including antiviral pattern-recognition-receptor induction and pathogen-driven destabilization.

    Evidence Abin-1+/- mice with RIPK1 inhibitor, and NLRP10 Co-IP/stability assays during Shigella infection

    PMID:30341420 PMID:30510071

    Open questions at the time
    • Direct vs indirect control of TLR3/RIG-I/MDA5 expression unresolved
    • NLRP10-TNIP1 axis tested in single cell system
  13. 2017 Medium

    Demonstrated post-translational and transcriptional counter-regulation of TNIP1 by IL-17, with A20-independent restraint of NF-κB.

    Evidence Protein stability/proteasome-inhibitor assays, NF-κB reporters, and A20 knockdown in fibroblasts

    PMID:30761389

    Open questions at the time
    • E3 ligase driving IL-17-induced degradation not identified
  14. 2022 Medium

    Defined a non-canonical role for TNIP1 in T-cell CBM signaling, where its suppressive function requires A20 and it antagonizes MALT1 cleavage of A20.

    Evidence Quantitative MS interactome, NF-κB and MALT1 protease assays, and overexpression/knockdown in activated T cells

    PMID:35099607

    Open questions at the time
    • Direct CBM-binding interface of TNIP1 not mapped
  15. 2022 High

    Connected inflammatory signaling to autophagic turnover of TNIP1: TBK1 phosphorylation activates its LIR motif to drive selective autophagic degradation that licenses inflammatory initiation.

    Evidence Phosphoproteomics, TBK1 inhibition, LIR mutagenesis, and autophagy-flux assays under TLR3 stimulation

    PMID:36574265

    Open questions at the time
    • Receptor delivering TNIP1 to autophagosomes not fully defined here
  16. 2022 High

    Established direct LC3 binding and a positive role for TNIP1 in clearing damaged mitochondria.

    Evidence Bacterial direct-binding assays, LIR mutagenesis, CRISPR knockout, and mitophagy flux reporters tracking VDAC-1/MFN2/TOM20

    PMID:36440857

    Open questions at the time
    • Apparent positive role contrasts with later negative-regulator model; context dependence not reconciled
  17. 2023 High

    Resolved TNIP1 as a negative regulator of mitophagy via bipartite LC3/GABARAP (LIR) and TAX1BP1 (AHD3) binding plus phosphorylation-controlled FIP200 association, letting it compete with autophagy receptors at autophagosome biogenesis.

    Evidence TNIP1-KO HeLa cells, domain mutagenesis, Co-IP with LC3/GABARAP/TAX1BP1/FIP200, and mitophagy flux assays

    PMID:36898370

    Open questions at the time
    • Kinase governing the FIP200-regulating phosphorylation not identified here
    • Reconciliation with positive mitophagy role unresolved
  18. 2023 High

    Identified m6A-dependent control of TNIP1: FTO demethylation represses TNIP1, derepressing NF-κB in endothelium with in vivo disease relevance.

    Evidence MeRIP-seq, RNA pull-down, luciferase assays, FTO knockdown, and AAV-Tnip1 rescue of diabetic retinal damage

    PMID:37781923

    Open questions at the time
    • m6A reader linking demethylation to TNIP1 stability/translation not defined
  19. 2024 High

    Linked a TNIP1 coding variant mechanistically to autoimmunity by showing Q333P impairs mitochondrial recruitment and MyD88/IRAK1 autophagosomal delivery, amplifying TLR7-driven disease.

    Evidence Whole-exome sequencing, knock-in mouse, cell-autonomous B-cell transfer, and TLR7/MyD88 epistasis with subcellular imaging

    PMID:39060650

    Open questions at the time
    • Structural basis by which Q333P disrupts membrane/receptor recruitment not solved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How TNIP1's distinct activities — NF-κB inhibition, death restraint, nuclear-receptor corepression, and autophagy regulation — are coordinated within a single cell, and how the positive vs negative mitophagy roles are reconciled, remains unresolved.
  • No integrated structural model of multidomain function
  • Context-dependence of mitophagy regulation unresolved
  • Quantitative balance between cytoplasmic and nuclear pools unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 2 GO:0060090 molecular adaptor activity 2 GO:0098772 molecular function regulator activity 2 GO:0140096 catalytic activity, acting on a protein 2 GO:0140110 transcription regulator activity 2
Localization
GO:0005739 mitochondrion 2 GO:0005634 nucleus 1 GO:0005829 cytosol 1
Pathway
R-HSA-168256 Immune System 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-9612973 Autophagy 3 R-HSA-162582 Signal Transduction 2
Partners
IKBKGMAP1LC3BPPARARARARB1CC1RIPK1TAX1BP1TNFAIP3
Complex memberships
A20 ubiquitin-editing complexCBM (CARD11-BCL10-MALT1) signalosomeTNF receptor signaling complex (TNF-RSC)

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 ABIN-1 (TNIP1) physically binds NEMO/IKKγ and facilitates A20-mediated de-ubiquitination of NEMO/IKKγ, thereby inhibiting NF-κB activation. ABIN-1 links A20 to NEMO/IKKγ; siRNA targeting ABIN-1 abrogates A20-dependent de-ubiquitination of NEMO/IKKγ. Co-immunoprecipitation, siRNA knockdown, NF-κB reporter assays The Journal of biological chemistry Medium 16684768
2003 ABIN-1 contains an ABIN homology domain (AHD) shared with IKKγ/NEMO; site-specific mutagenesis of this AHD2 region abolishes NF-κB inhibitory function without affecting A20 interaction, indicating A20 binding and NF-κB inhibition are separable activities. Dominant-negative AHD2 mutants interfere with ABIN-1 but not A20-mediated NF-κB inhibition. Site-directed mutagenesis, NF-κB reporter assays, co-immunoprecipitation FEBS letters Medium 12586352
2008 ABIN-1 directly binds polyubiquitin chains (ubiquitin-sensing activity), and this activity is required for its anti-apoptotic function. ABIN-1-deficient mice die embryonically with fetal liver apoptosis rescued by TNF deficiency; ABIN-1 inhibits caspase-8 recruitment to FADD in TNF-induced signaling complexes, preventing caspase-8 cleavage and programmed cell death. Knockout mouse model, genetic rescue (TNF deficiency), biochemical ubiquitin-binding assays, signaling complex analysis Nature High 19060883
2017 ABIN-1 is recruited to the TNF-RSC in a LUBAC-dependent (Met1-ubiquitin-dependent) manner and regulates A20 recruitment to control Lys63 deubiquitylation of RIPK1. ABIN-1 deficiency reduces A20 recruitment, promotes Lys63 ubiquitylation and activation of RIPK1, and licenses necroptosis. RIPK1 kinase inhibition and RIPK3 deficiency rescue embryonic lethality of Abin-1−/− mice. Knockout mouse model, genetic rescue experiments, biochemical analysis of TNF-RSC complex, ubiquitylation assays, RIPK1 kinase inhibitor treatment Nature cell biology High 29203883
2009 ABIN-1 inhibits NF-κB by blocking processing of the p105 precursor to the p50 active subunit. ABIN-1 physically interacts with p105, and this interaction stabilizes ABIN-1 and increases its inhibitory effect. The AHD2 domain of ABIN-1 is required for inhibition of p105 processing. Co-immunoprecipitation, NF-κB reporter assays, domain deletion analysis, Western blotting Biochemical and biophysical research communications Medium 19695220
2005 Adenoviral ABIN-1 expression protects mice from TNF/galactosamine-induced acute liver failure; ABIN-1 prevents both TNF-induced NF-κB activation and hepatocyte apoptosis, demonstrating an NF-κB-independent anti-apoptotic activity distinct from IκBα superrepressor. Adenoviral gene transfer in murine liver failure model, comparison with IκBα superrepressor, histological analysis of apoptosis and inflammation Hepatology Medium 16025521
2013 ABIN-1 deficiency specifically in dendritic cells leads to exaggerated NF-κB and MAPK signaling and increased IL-23 production in response to TLR ligands. DC-specific ABIN-1 deletion causes psoriasiform lesions upon TLR7 challenge, and these phenotypes are reversed by DC-specific deletion of the TLR adaptor MyD88, placing ABIN-1 upstream of MyD88 in DC TLR signaling. Conditional knockout mice (CD11c-Cre), MyD88 genetic epistasis, cytokine measurements, flow cytometry for Th17/TCRγδ T cells Journal of immunology High 23785118
2016 Loss of Tnip1 in keratinocytes leads to deregulated IL-17-induced gene expression and exaggerated chemokine production in vitro and overt psoriasis-like inflammation in vivo; tissue-specific deletion established that keratinocytes are a cell-autonomous contributor to psoriasis pathogenesis through TNIP1. Tissue-specific conditional knockout mice, in vitro keratinocyte stimulation with IL-17, in vivo inflammatory triggers Proceedings of the National Academy of Sciences of the United States of America High 27671649
2018 A20 and ABIN-1 synergistically restrict TNF-induced caspase-8 activation and RIPK1 kinase activity in intestinal epithelial cells. Simultaneous IEC-specific deletion of both A20 and ABIN-1 causes spontaneous cell death and mouse lethality; single deletion of either alone has negligible effect. Inhibition of RIPK1 kinase alone, or caspase inhibition plus RIPK3 deletion, rescues the double-deficient phenotype. Conditional double-knockout mice, enteroid culture, genetic rescue experiments (RIPK1 inhibitor, RIPK3 deletion, caspase inhibition), caspase-8 activation assays The Journal of experimental medicine High 29930103
2022 TBK1 phosphorylates TNIP1 under inflammatory conditions (TLR3/poly(I:C) stimulation), activating its LIR motif and leading to selective autophagy-dependent degradation of TNIP1. This early (0–4 h) degradation allows efficient initiation of the inflammatory response, after which TNIP1 levels are restored by increased transcription to prevent sustained inflammation. Phosphoproteomics, TBK1 inhibitor treatment, autophagy flux assays, LIR motif mutagenesis, quantitative proteomics The Journal of cell biology High 36574265
2023 TNIP1 negatively regulates mitophagy via a bipartite interaction: an evolutionarily conserved LIR motif binds LC3/GABARAP family proteins, and an AHD3 domain binds autophagy receptor TAX1BP1. TNIP1 knockout accelerates mitophagy; phosphorylation of TNIP1 regulates its association with the ULK1 complex member FIP200, allowing TNIP1 to compete with autophagy receptors at early steps of autophagosome biogenesis. TNIP1 knockout HeLa cells, ectopic overexpression, LIR/AHD3 domain mutagenesis, Co-IP with LC3/GABARAP/TAX1BP1/FIP200, mitophagy flux assays Molecular cell High 36898370
2022 ABIN-1 is recruited to the CBM (CARD11-BCL10-MALT1) signalosome in activated T cells; its suppressive function in T cells depends on A20. A20 suppresses CBM complex-triggered NF-κB and MALT1 protease activity independent of ABIN-1, but ABIN-1's suppressive function requires A20. A20/ABIN-1 is recruited via A20 ZnF4/7; proteasomal degradation of both releases the CBM from negative regulation. ABIN-1 also antagonizes MALT1-catalyzed cleavage of re-synthesized A20. Quantitative mass spectrometry interactome, T cell activation assays, NF-κB reporter, MALT1 protease assay, overexpression and knockdown experiments Cellular and molecular life sciences Medium 35099607
2018 ABIN-1 heterozygosity sensitizes cells to antiviral response by mediating NF-κB-dependent, RIPK1-independent upregulation of pattern recognition molecules TLR3, RIG-I, and MDA5. Prolonged poly(I:C) stimulation leads to A20-dependent reduction of ABIN-1 protein. RIPK1 kinase inhibition partially reduces pattern recognition molecule expression in Abin-1+/- but not WT mice. Heterozygous Abin-1+/- mouse model, in vivo cytokine measurements, MEF signaling studies, RIPK1 kinase inhibitor treatment Cell death and differentiation Medium 30341420
2017 IL-17 signaling induces proteasome-dependent degradation of ABIN-1 protein, while simultaneously inducing ABIN-1 mRNA through NF-κB. ABIN-1 restricts both baseline and IL-17-induced NF-κB signaling independently of A20 in IL-17-responsive fibroblasts. Protein stability assays, proteasome inhibitor treatment, NF-κB reporter assays, siRNA knockdown of A20, promoter activity assays ImmunoHorizons Medium 30761389
2009 TNIP1 interacts with liganded RARα and RARγ via NR boxes (LXXLL motifs) in a ligand- and receptor AF-2 domain-dependent manner characteristic of coactivators, yet TNIP1 represses RAR transcriptional activity. Repression is partially relieved by SRC1 coactivator, suggesting TNIP1 competes with coactivators. RARα preference over RARγ maps to helices 5-9 of the RARα ligand-binding domain. Two-hybrid assays, co-immunoprecipitation, RAR transcriptional activity reporter assays, domain deletion mapping Biochemical and biophysical research communications Medium 19732752
2011 TNIP1 is an atypical corepressor of agonist-bound PPARα (and other PPARs); identified from a PPARα screen of a human keratinocyte cDNA library. TNIP1-PPAR interaction requires ligand and the receptor AF-2 domain. TNIP1 has separable transcriptional activation and repression domains. TNIP1 partially decreases PPAR transcriptional activity. cDNA library two-hybrid screen, co-immunoprecipitation, PPAR transcriptional reporter assays, domain deletion analysis Archives of biochemistry and biophysics Medium 21967852
2011 TNIP1 localizes to both cytoplasm and nucleus in normal human skin keratinocytes, where it co-localizes with RARα. Nuclear and cytoplasmic distribution is also observed in malignant keratinocytes of squamous cell carcinomas, with varying levels in different tumor types. Immunohistochemistry, co-localization analysis in tissue sections and cultured cells The journal of histochemistry and cytochemistry Medium 22147607
2011 PPARγ and NF-κB directly regulate the TNIP1 gene promoter; validated NF-κB binding sites in proximal and distal promoter regions and one PPRE in the distal region were confirmed by EMSA and ChIP assays, establishing a feedback loop where NF-κB and PPARγ control their own inhibitor. Luciferase reporter assays, EMSA, chromatin immunoprecipitation (ChIP), expression studies Biochimica et biophysica acta Medium 22001530
2012 TNIP1 promoter is activated by retinoic acid (ATRA) via RAR-responsive elements (RAREs) in proximal and distal promoter regions, confirmed by EMSA, ChIP, and luciferase assays. This establishes a feedback loop: RARs activate TNIP1 expression, and TNIP1 in turn attenuates RAR activity. Luciferase reporter assays, EMSA, ChIP, expression studies with ATRA treatment Gene Medium 23228856
2018 NLRP10 binds ABIN-1 through its NACHT domain and destabilizes ABIN-1, resulting in enhanced proinflammatory NF-κB signaling during Shigella flexneri infection in human epithelial cells. Co-immunoprecipitation (NLRP10-ABIN-1), domain mapping, protein stability assays, NF-κB signaling readouts in infected cells Journal of immunology Medium 30510071
2022 ABIN-1 directly binds LC3A and LC3B via LIR motifs (LIR1 and LIR2); mutations in both LIR motifs abolish ABIN-1/LC3B-II complex formation. ABIN-1 translocates to damaged mitochondria and promotes mitophagy; CRISPR/Cas9 deletion of ABIN-1 inhibits degradation of outer mitochondrial membrane proteins VDAC-1, MFN2, and TOM20. Bacterial protein expression and direct binding assays, LIR motif mutagenesis, colocalization (fluorescence microscopy), CRISPR knockout, siRNA knockdown, mitophagy flux reporters American journal of physiology. Cell physiology High 36440857
2017 ABIN-1 physically associates with the μ-opioid receptor (MOR) C-terminal tail, confirmed by bacterial two-hybrid screen and co-immunoprecipitation. ABIN-1 inhibits DAMGO-induced G protein activation, MOR phosphorylation, ubiquitination, internalization, and ERK activation in CHO cells. ABIN-1 morpholino knockdown in zebrafish increases morphine-induced hyperlocomotion. Bacterial two-hybrid screen, co-immunoprecipitation, G protein activation assay (GTPγS), radioligand binding, adenylyl cyclase assay, zebrafish morpholino knockdown Molecular pharmacology Medium 29237725
2023 FTO (m6A demethylase) erases m6A methylation on TNIP1 mRNA, repressing TNIP1 expression. FTO-mediated reduction of TNIP1 activates NF-κB and inflammatory factors in endothelial cells. Confirmed by MeRIP-seq, RNA-seq, luciferase activity assays, and RNA pull-down; intravitreal AAV-Tnip1 delivery alleviates diabetic retinal vascular damage. MeRIP-sequencing, RNA-seq, luciferase activity assays, RNA pull-down, FTO knockdown, AAV-mediated TNIP1 overexpression in vivo The Journal of clinical investigation High 37781923
2024 A TNIP1 Q333P variant impairs TNIP1 localization to damaged mitochondria and mitophagosome formation, and impairs MyD88 and IRAK1 recruitment to autophagosomes, resulting in increased interferon-β and TLR7-driven autoimmunity. B cell autoimmune phenotypes from this variant are cell-autonomous and rescued by ablation of TLR7 or MyD88. Whole-exome sequencing, knock-in mouse model (Q346P), cell-autonomous B cell transfer experiments, TLR7/MyD88 knockout epistasis, mitochondrial localization imaging, autophagosome recruitment assays Nature immunology High 39060650
2016 LILRB1 ligation during monocyte-to-DC differentiation increases ABIN1/TNIP1 expression, mediating inhibitory effects on DC function. siRNA-mediated reduction of ABIN1/TNIP1 in these cells allows NF-κB nuclear translocation, increased surface antigen presentation molecules, phagocytic capacity, proinflammatory cytokine secretion, and T cell stimulation. siRNA knockdown of TNIP1 in DCs/monocytes, NF-κB translocation assay, flow cytometry for surface markers, phagocytosis assay, cytokine ELISA, T cell co-culture Journal of leukocyte biology Medium 27129285

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. Nature genetics 657 12219090
1998 Van Gogh: a new Drosophila tissue polarity gene. Genetics 263 9725839
2020 General synthesis of two-dimensional van der Waals heterostructure arrays. Nature 239 32188941
2000 Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis. Nature genetics 231 10700184
2006 ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB. The Journal of biological chemistry 222 16684768
2011 Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis. PLoS genetics 187 21750679
2007 Ellis-van Creveld syndrome. Orphanet journal of rare diseases 146 17547743
2008 ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature 142 19060883
2021 Van der Waals engineering of ferroelectric heterostructures for long-retention memory. Nature communications 116 33597507
2014 Many-body van der Waals interactions in molecules and condensed matter. Journal of physics. Condensed matter : an Institute of Physics journal 108 24805055
1998 Van Buchem disease (hyperostosis corticalis generalisata) maps to chromosome 17q12-q21. American journal of human genetics 105 9463328
2015 ProteinVolume: calculating molecular van der Waals and void volumes in proteins. BMC bioinformatics 102 25885484
2003 Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1. FEBS letters 102 12586352
1999 Localization of the gene for sclerosteosis to the van Buchem disease-gene region on chromosome 17q12-q21. American journal of human genetics 97 10330353
2013 Van Buchem disease: clinical, biochemical, and densitometric features of patients and disease carriers. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 94 23074140
2017 ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC. Nature cell biology 91 29203883
2019 Self-selective van der Waals heterostructures for large scale memory array. Nature communications 88 31320651
2004 Van Gogh-like2 (Strabismus) and its role in planar cell polarity and convergent extension in vertebrates. Trends in genetics : TIG 88 15475117
2017 Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis. Nature communications 76 28931804
2016 Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function. Proceedings of the National Academy of Sciences of the United States of America 71 27671649
2010 Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study. Arthritis research & therapy 71 20849588
2023 FTO fuels diabetes-induced vascular endothelial dysfunction associated with inflammation by erasing m6A methylation of TNIP1. The Journal of clinical investigation 67 37781923
2012 Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus. Arthritis and rheumatism 64 22833143
2017 Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal models. Metabolism: clinical and experimental 59 29080811
2012 Emerging roles for TNIP1 in regulating post-receptor signaling. Cytokine & growth factor reviews 59 22542476
2012 Novel and recurrent EVC and EVC2 mutations in Ellis-van Creveld syndrome and Weyers acrofacial dyostosis. European journal of medical genetics 59 23220543
2018 TNIP1 in Autoimmune Diseases: Regulation of Toll-like Receptor Signaling. Journal of immunology research 58 30402506
2019 Optoelectronic and solar cell applications of Janus monolayers and their van der Waals heterostructures. Physical chemistry chemical physics : PCCP 57 31414085
2012 Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study. Annals of the rheumatic diseases 53 22896740
2018 A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival. The Journal of experimental medicine 52 29930103
1977 Van der Waals interactions between cell surfaces. The Journal of membrane biology 46 839528
2019 Van der Waals Potential in Protein Complexes. Methods in molecular biology (Clifton, N.J.) 45 31452100
2013 Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. Journal of immunology (Baltimore, Md. : 1950) 45 23785118
2011 Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population. Arthritis research & therapy 45 22087647
2017 GLI1 inactivation is associated with developmental phenotypes overlapping with Ellis-van Creveld syndrome. Human molecular genetics 44 28973407
2003 Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays. FEBS letters 43 12965196
2020 Episignatures Stratifying Helsmoortel-Van Der Aa Syndrome Show Modest Correlation with Phenotype. American journal of human genetics 42 32758449
2005 Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality. Hepatology (Baltimore, Md.) 40 16025521
2004 Identification and developmental expression pattern of van gogh-like 1, a second zebrafish strabismus homologue. Gene expression patterns : GEP 36 15053985
2005 Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model. The Journal of biological chemistry 35 15722346
1986 Genetic epidemiology and control of genetic expression in van der Woude syndrome. Journal of craniofacial genetics and developmental biology. Supplement 34 3491128
2023 Genomic analyses of hair from Ludwig van Beethoven. Current biology : CB 33 36958333
2009 Analysis of Ellis van Creveld syndrome gene products: implications for cardiovascular development and disease. Human molecular genetics 33 19251731
2013 Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in Chinese population. Rheumatology international 32 24091983
2023 TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1. Molecular cell 31 36898370
2018 The Dynamics of Chemical Reactions: Atomistic Visualizations of Organic Reactions, and Homage to van 't Hoff. Chemistry (Weinheim an der Bergstrasse, Germany) 31 29512895
2003 Novel mutations in the IRF6 gene for Van der Woude syndrome. Human genetics 30 12920575
2009 ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor. Biochemical and biophysical research communications 29 19695220
2019 TNIP1-mediated TNF-α/NF-κB signalling cascade sustains glioma cell proliferation. Journal of cellular and molecular medicine 28 31691497
2015 Downregulation of TNIP1 Expression Leads to Increased Proliferation of Human Keratinocytes and Severer Psoriasis-Like Conditions in an Imiquimod-Induced Mouse Model of Dermatitis. PloS one 28 26046540
2011 TNIP1, a retinoic acid receptor corepressor and A20-binding inhibitor of NF-κB, distributes to both nuclear and cytoplasmic locations. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 28 22147607
2018 TNIP1 Regulates Cutibacterium acnes-Induced Innate Immune Functions in Epidermal Keratinocytes. Frontiers in immunology 27 30319618
2017 Genetic, Radiologic, and Clinical Variability in Brown-Vialetto-van Laere Syndrome. Seminars in pediatric neurology 27 29961509
2023 Amelioration of ovalbumin gel properties by EGCG via protein aggregation, hydrogen, and van der Waals force. Food chemistry 26 37126957
2022 TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1. The Journal of cell biology 26 36574265
2018 ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner. Cell death and differentiation 26 30341420
2013 TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis. Journal of dermatological science 26 23541940
2024 Broadband miniaturized spectrometers with a van der Waals tunnel diode. Nature communications 25 38233431
2022 Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1. Genome medicine 25 35042540
2022 A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells. Cellular and molecular life sciences : CMLS 24 35099607
2021 ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer. Cell death & disease 24 33542218
2017 Interleukin-17 signaling triggers degradation of the constitutive NF-κB inhibitor ABIN-1. ImmunoHorizons 24 30761389
2009 Liganded RARalpha and RARgamma interact with but are repressed by TNIP1. Biochemical and biophysical research communications 23 19732752
2021 Microbial community of soda Lake Van as obtained from direct and enriched water, sediment and fish samples. Scientific reports 21 34526632
2013 Search for genetic modifiers of IRF6 and genotype-phenotype correlations in Van der Woude and popliteal pterygium syndromes. American journal of medical genetics. Part A 21 23949966
2004 A novel mutation of the IRF6 gene in an Italian family with Van der Woude syndrome. Mutation research 21 15013698
2017 Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol. Scientific reports 20 28473721
2011 TNIP1 is a corepressor of agonist-bound PPARs. Archives of biochemistry and biophysics 20 21967852
2011 PPARγ and NF-κB regulate the gene promoter activity of their shared repressor, TNIP1. Biochimica et biophysica acta 20 22001530
2003 A common mutation and a novel mutation in Japanese patients with van der Knaap disease. Journal of human genetics 20 14615938
2012 Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS. Neurobiology of disease 19 22766032
2008 Van-den Berghe's 5q- syndrome in 2008. British journal of haematology 19 19016715
2018 NLRP10 Affects the Stability of Abin-1 To Control Inflammatory Responses. Journal of immunology (Baltimore, Md. : 1950) 18 30510071
2017 Relationship between the TERT, TNIP1 and OBFC1 genetic polymorphisms and susceptibility to colorectal cancer in Chinese Han population. Oncotarget 18 28915643
2013 Single-nucleotide polymorphism and haplotypes of TNIP1 associated with systemic lupus erythematosus in a Chinese Han population. The Journal of rheumatology 17 23858047
2025 Interlayer reconstruction phase transition in van der Waals materials. Nature materials 16 39856414
2020 TNIP1/ABIN1 and lupus nephritis: review. Lupus science & medicine 16 33122334
2014 Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population. International journal of immunogenetics 16 25264125
2013 Van-Gogh-like 2 antagonises the canonical WNT pathway and is methylated in colorectal cancers. British journal of cancer 16 23579212
2013 Analysis of germ cell proliferation, apoptosis, and androgenesis in the Lake Van fish (Chalcalburnus tarichi) during testicular development. Fish physiology and biochemistry 16 23756825
2018 TNIP1 reduction sensitizes keratinocytes to post-receptor signalling following exposure to TLR agonists. Cellular signalling 15 29413846
2015 Clinical manifestations and laboratory findings of 496 children with brucellosis in Van, Turkey. Pediatrics international : official journal of the Japan Pediatric Society 15 25675977
2015 TNFAIP3 and TNIP1 polymorphisms confer psoriasis risk in South Indian Tamils. British journal of biomedical science 15 26738398
2024 A TNIP1-driven systemic autoimmune disorder with elevated IgG4. Nature immunology 13 39060650
2021 Brown-Vialetto-Van Laere and Fazio-Londe syndromes: SLC52A3 mutations with puzzling phenotypes and inheritance. European journal of neurology 13 33325104
2018 TNIP1 alleviates hepatic ischemia/reperfusion injury via the TLR2-Myd88 pathway. Biochemical and biophysical research communications 13 29709475
2008 Identification of IRF6 gene variants in three families with Van der Woude syndrome. International journal of molecular medicine 13 18506368
2006 Multiple splicing variants of Naf1/ABIN-1 transcripts and their alterations in hematopoietic tumors. International journal of molecular medicine 13 17016622
2006 A novel missense mutation in Van der Woude syndrome: usefulness of fingernail DNA for genetic analysis. Journal of dental research 13 17122170
2016 Truncation and microdeletion of EVC/EVC2 with missense mutation of EFCAB7 in Ellis-van Creveld syndrome. Congenital anomalies 12 26748586
2016 Leukocyte Ig-Like receptor B1 restrains dendritic cell function through increased expression of the NF-κB regulator ABIN1/TNIP1. Journal of leukocyte biology 12 27129285
2014 Transposon-dependent induction of Vincent van Gogh's sunflowers: exceptions revealed. Genesis (New York, N.Y. : 2000) 12 24443180
2018 Association of Tumor Necrosis Factor Alpha-Induced Protein 3 Interacting Protein 1 (TNIP1) Gene Polymorphism (rs7708392) with Lupus Nephritis in Egyptian Patients. Biochemical genetics 11 29589214
2022 A20 binding and inhibitor of nuclear factor kappa B (NF-κB)-1 (ABIN-1): a novel modulator of mitochondrial autophagy. American journal of physiology. Cell physiology 10 36440857
2015 Ellis-van Creveld Syndrome in Grey Alpine Cattle: Morphologic, Immunophenotypic, and Molecular Characterization. Veterinary pathology 10 26077781
2012 Human TNFα-induced protein 3-interacting protein 1 (TNIP1) promoter activation is regulated by retinoic acid receptors. Gene 10 23228856
2011 Novel IRF6 mutations in Honduran Van der Woude syndrome patients. Molecular medicine reports 10 21468557
1996 Exclusion of the MSX1 homeobox gene as the gene for the Ellis van Creveld syndrome in the Amish. Human genetics 10 8882877
2020 ABIN-1 protects chondrocytes from lipopolysaccharide-induced inflammatory injury through the inactivation of NF-κB signalling. Clinical and experimental pharmacology & physiology 9 32100889
2017 ABIN-1 Negatively Regulates μ-Opioid Receptor Function. Molecular pharmacology 9 29237725

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