Affinage

TNFSF14

Tumor necrosis factor ligand superfamily member 14 · UniProt O43557

Length
240 aa
Mass
26.4 kDa
Annotated
2026-06-10
100 papers in source corpus 17 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TNFSF14 (LIGHT) is a TNF-superfamily cytokine that drives inflammation and tissue remodeling by signaling through two cell-surface receptors, HVEM and LTβR, with HVEM additionally functioning as a molecular switch through its interaction with the inhibitory adaptor BTLA to suppress T-cell activation (PMID:18613837, PMID:19760072). Receptor choice partitions LIGHT's effects: LTβR mediates proinflammatory and remodeling activation of primary lung fibroblasts—proliferation and induction of adhesion molecules, cytokines, chemokines, and matrix-remodeling enzymes (PMID:29616048)—and supports survival and proliferation of mesenchymal stem cells via STAT3- and Smad3-dependent PDGF/TGFβ production (PMID:27835685), whereas HVEM transduces LIGHT's chemotactic and cytokine-inducing effects in macrophages and adipose tissue (PMID:21236258). Downstream, LIGHT engages canonical and non-canonical NFκB, with the p52 subunit binding and transactivating the HIF-2α promoter (PMID:30096845), and activates Akt/JNK during osteoclastogenesis (PMID:25460501) and a PI3Kγ/SGK1 axis that polarizes macrophages toward TGF-β1 secretion (PMID:37580750). Through these circuits LIGHT promotes endothelial activation and platelet adhesion (PMID:17938804), osteoclast formation and osteolytic bone remodeling (PMID:25460501, PMID:31826304), cardiac fibrosis (PMID:37580750), and hepatic/adipose metabolic inflammation, since Tnfsf14-deficient mice are protected from diet-induced glucose intolerance and NAFLD (PMID:31388695). LIGHT is produced by activated NK cells to license dendritic-cell maturation (PMID:25512551) and, when forced into tumors or co-expressed on CAR-T cells, organizes intratumoral lymphoid structures, recruits and expands antigen-specific CD8+ T cells, and enhances anti-tumor efficacy (PMID:20460520, PMID:37408308).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2008 High

    Established the core receptor architecture of LIGHT signaling—that it engages both HVEM and LTβR, is buffered by the soluble decoy DcR3, and that HVEM doubles as a stimulatory/inhibitory switch through BTLA—defining the receptor logic for all downstream biology.

    Evidence Receptor binding and biochemical/genetic characterization synthesized from experimental data

    PMID:18613837 PMID:19760072

    Open questions at the time
    • Does not resolve which cell types preferentially use HVEM versus LTβR
    • Structural basis of the HVEM stimulatory/inhibitory switch not detailed
  2. 2007 High

    Showed LIGHT is a platelet-borne effector that bridges thrombosis and vascular inflammation, mediating platelet-endothelial adhesion and driving endothelial ICAM-1, tissue factor, and IL-8 via NFκB.

    Evidence Platelet adhesion under static/flow conditions, antibody blockade, and NFκB/expression assays in human endothelial cells

    PMID:17938804

    Open questions at the time
    • Receptor (TR2/HVEM vs LTβR) responsible for endothelial activation not isolated
    • In vivo relevance to vascular disease not tested here
  3. 2010 Medium

    Demonstrated LIGHT can reprogram the tumor microenvironment, converting tumors into lymphoid-like tissue that recruits naive T cells and expands functional antigen-specific CD8+ responses, establishing its immunotherapeutic potential.

    Evidence Adenoviral LIGHT overexpression in tumors with cytokine, TIL, and T-cell functional readouts in mouse models

    PMID:20460520

    Open questions at the time
    • Receptor mediating lymphoid neogenesis not pinned down
    • Single-lab in vivo model
  4. 2014 High

    Identified licensed NK cells as a physiological source of LIGHT and linked NK-derived LIGHT to dendritic-cell maturation, connecting innate activation to adaptive priming.

    Evidence Gene expression profiling, protein detection, and antibody neutralization of DC maturation in human NK-cell assays

    PMID:25512551

    Open questions at the time
    • Receptor on DCs mediating maturation not defined
    • Whether membrane or soluble LIGHT drives the effect unresolved
  5. 2014 High

    Defined LIGHT as a regulator of bone homeostasis, driving osteoclastogenesis both with and independently of RANKL through Akt/NFκB/JNK while suppressing osteoblast formation.

    Evidence In vitro osteoclast/osteoblast differentiation and colony assays with phospho-signaling western blots

    PMID:25460501

    Open questions at the time
    • Receptor specificity for osteoclast versus osteoblast effects not separated
    • Sclerostin-mediated osteoblast suppression mechanism incompletely mapped
  6. 2016 Medium

    Revealed an LTβR-dependent pro-survival/proliferative program in mesenchymal stem cells driven by STAT3 and Smad3 signaling and autocrine PDGF/TGFβ, broadening LIGHT's role beyond immune cells to stromal expansion.

    Evidence rhLIGHT treatment of BM-MSCs with cell-cycle analysis, ELISA, and immunoblotting

    PMID:27835685

    Open questions at the time
    • Direct vs PDGF/TGFβ-indirect contributions to proliferation not separated
    • Single-lab study
  7. 2018 High

    Extended the fibroblast-activating role of LIGHT to the lung and assigned it specifically to LTβR rather than HVEM, identifying a remodeling/inflammatory gene program relevant to airway disease.

    Evidence Recombinant LIGHT on primary human lung fibroblasts with receptor-specific blockade and gene/protein expression assays

    PMID:29616048

    Open questions at the time
    • In vivo contribution to fibrotic disease not addressed
    • Signaling intermediates downstream of LTβR not dissected
  8. 2018 Medium

    Connected LIGHT's non-canonical NFκB output to hypoxia signaling, showing the p52 subunit selectively transactivates HIF-2α by binding its promoter, providing a transcriptional mechanism for LIGHT-driven gene programs.

    Evidence Reporter assays, qRT-PCR, western blot, and ChIP for p52 binding to the HIF-2α promoter

    PMID:30096845

    Open questions at the time
    • Physiological consequences of HIF-2α induction not tested
    • Selectivity for HIF-2α over HIF-1α mechanism incompletely explained
  9. 2019 High

    Genetic loss-of-function established LIGHT as a causal driver of metabolic inflammation, with Tnfsf14-/- mice protected from diet-induced glucose intolerance and NAFLD and showing a shift toward anti-inflammatory adipose macrophages.

    Evidence Tnfsf14-/- mice on high-fat high-cholesterol diet with metabolic, histological, and hepatic gene-expression readouts

    PMID:31388695

    Open questions at the time
    • Cellular source of pathogenic LIGHT in metabolic tissue not identified
    • Receptor mediating the metabolic phenotype not isolated
  10. 2019 Medium

    Placed TNFSF14 under post-transcriptional control by miR-326, with miR-326-mediated suppression dampening silica-induced pulmonary inflammation, defining an upstream regulatory node.

    Evidence Luciferase target validation, miR-326 overexpression in a mouse fibrosis model, western blot and immunofluorescence

    PMID:31642316

    Open questions at the time
    • Insight is on regulation of TNFSF14 rather than protein mechanism
    • Single-lab validation
  11. 2020 High

    Demonstrated that LIGHT is required for osteolytic bone metastasis, since Tnfsf14-/- mice resist tumor-driven bone loss, translating the in vitro osteoclastogenic role into a pathological in vivo requirement.

    Evidence Intratibial NSCLC implantation in WT vs Tnfsf14-/- mice with histomorphometry and PBMC blocking assays

    PMID:31826304

    Open questions at the time
    • Tumor- vs host-derived LIGHT contribution not separated
    • Receptor driving metastatic osteolysis not defined
  12. 2023 High

    Defined a macrophage-to-fibroblast paracrine fibrotic circuit in which LIGHT activates PI3Kγ/SGK1 to drive M2 polarization and TGF-β1 secretion, promoting cardiac fibrosis and atrial fibrillation vulnerability.

    Evidence In vivo rLIGHT injection, BMDM stimulation, conditioned-medium transfer to cardiac fibroblasts with PI3Kγ/SGK1 inhibitors and RNA-seq

    PMID:37580750

    Open questions at the time
    • Receptor coupling to PI3Kγ/SGK1 not specified
    • Direct fibroblast effects of LIGHT versus macrophage-mediated effects not fully separated
  13. 2023 Medium

    Showed that engineering LIGHT onto CAR-T cells enhances cytotoxicity, induces CCL19/CCL21 to recruit T cells, normalizes tumor vasculature, and improves anti-tumor efficacy, advancing LIGHT as a programmable immunotherapy module.

    Evidence In vitro cytotoxicity/chemokine/migration assays plus NSG xenograft and syngeneic mouse tumor models

    PMID:37408308

    Open questions at the time
    • Receptor mediating chemokine induction and vascular normalization not isolated
    • Single-lab study

Open questions

Synthesis pass · forward-looking unresolved questions
  • How HVEM versus LTβR engagement, BTLA/DcR3 competition, and membrane versus soluble LIGHT are coordinated to select between stimulatory, inhibitory, and remodeling outcomes across tissues remains unresolved.
  • No structural model of context-dependent receptor selection
  • Cell-type-specific receptor usage in vivo largely uncharacterized
  • Quantitative role of DcR3 decoy buffering in disease not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 3 GO:0060089 molecular transducer activity 1
Localization
GO:0005886 plasma membrane 2 GO:0005576 extracellular region 1 GO:0031410 cytoplasmic vesicle 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-168256 Immune System 3 R-HSA-1474244 Extracellular matrix organization 2
Partners
BTLADCR3HVEMLTBR

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 LIGHT (TNFSF14) activates two cell surface receptors: the Herpesvirus Entry Mediator (HVEM) and the Lymphotoxin-beta Receptor (LTβR), and is inhibited by soluble decoy receptor-3 (DcR3). HVEM also binds the Ig superfamily member BTLA, which inhibits T-cell activation, making HVEM a molecular switch between stimulatory and inhibitory signaling. Receptor binding studies, genetic and biochemical characterization described in review of experimental data Immunological reviews High 18613837 19760072
2014 TNFSF14 (LIGHT) protein expression is rapidly induced in human NK cells by three mechanisms: CD16 engagement, synergistic activity of multiple NK-cell activation receptors, and IL-2/IL-15 cytokine stimulation. TNFSF14 is preferentially produced by licensed NK cells (defined by inhibitory receptors specific for self-MHC class I). Tumor- and cytokine-activated NK cells induced DC maturation in a TNFSF14-dependent manner, as shown by antibody blocking experiments. Gene expression profiling, TNFSF14 protein detection, antibody neutralization of TNFSF14-dependent DC maturation, NK cell activation assays Proceedings of the National Academy of Sciences of the United States of America High 25512551
2018 TNFSF14/LIGHT activates proinflammatory and remodeling activities in primary human lung fibroblasts (HLFs) including cell cycle progression, proliferation, upregulation of ICAM-1, VCAM-1, IL-6, GM-CSF, CCL5, CCL20, CXCL5/11/12, MMP-9, ADAM8, IL-33, and TSLP. These effects were dependent on LTβR but not HVEM signaling. Recombinant LIGHT treatment of primary HLFs, receptor-specific blocking, gene/protein expression analysis (ELISA, qPCR), proliferation assays Frontiers in immunology High 29616048
2007 Platelet-associated LIGHT (TNFSF14) mediates adhesion of platelets to human vascular endothelium under both static and dynamic flow conditions, and this interaction is inhibited by a monoclonal antibody to LIGHT. Soluble LIGHT stimulates endothelial cells to upregulate ICAM-1, tissue factor, and IL-8 via NFκB activation. LIGHT is expressed on platelets upon ADP or TRAP-1 activation, and its receptors TR2 and LTβR are expressed on human endothelial cells. FACS analysis of receptor expression, platelet adhesion assays (static and flow), antibody blockade, ICAM-1/TF/IL-8 expression measurement, NFκB activation assay Thrombosis and haemostasis High 17938804
2011 Soluble LIGHT (sLIGHT) displays chemotactic activity for macrophages and T cells, and enhances inflammatory cytokine release from macrophages, adipocytes, and adipose tissue-derived stromal vascular fraction cells. These inflammatory responses were blunted by neutralizing anti-HVEM antibody or HVEM knockout, identifying HVEM as the receptor mediating LIGHT's adipose tissue inflammatory effects. Chemotaxis assays, cytokine measurement (ELISA), antibody neutralization, HVEM knockout cells FEBS letters High 21236258
2014 LIGHT (TNFSF14) induces osteoclastogenesis in both RANKL-dependent and RANKL-independent manners. In the presence of sub-optimal RANKL, LIGHT and RANKL synergistically stimulate osteoclast formation via phosphorylation of Akt, NFκB, and JNK pathways. LIGHT also inhibits osteoblastogenesis, partly through sclerostin expressed by monocytes. In vitro osteoclast/osteoblast differentiation cultures, signaling pathway analysis (western blot for phospho-Akt, NFκB, JNK), CFU-F and CFU-OB colony assays, osteoblastic marker expression Oncotarget High 25460501
2018 TNFSF14/LIGHT, acting as a non-canonical NF-κB stimulus, induces the HIF pathway specifically by upregulating HIF-2α transcription (but not HIF-1α) via a mechanism dependent on the p52 NF-κB subunit. p52 was shown to bind the HIF-2α promoter in cells. Reporter assays, western blot, qRT-PCR, chromatin immunoprecipitation (ChIP) for p52 binding to HIF-2α promoter Cells Medium 30096845
2005 Human melanoma cells constitutively express LIGHT/TNFSF14 intracellularly and on tumor-derived microvesicles. LIGHT+ melanoma-derived microvesicles costimulated LIGHT-dependent CD3+CD8+ T-cell proliferation in the presence of IL-2, but also induced apoptosis (increased Annexin V binding) of CD8+ T cells. Immunostaining, microvesicle isolation, co-culture assays, flow cytometry (Annexin V, T cell proliferation) Cancer research Medium 15833878
2008 LIGHT and its receptors HVEM and LTβR are upregulated in experimental heart failure (post-infarction rats) with strong expression in the infarcted area and HVEM upregulation in cardiomyocytes and endothelial cells. LIGHT induced IL-6 expression in endothelial cells in vitro; in HF patients (but not healthy controls), LIGHT-activated PBMCs also showed IL-6-inducing activity. Immunohistochemistry, in vitro endothelial cell stimulation, PBMC activation assays, IL-6 measurement European journal of heart failure Medium 18353719
2016 LIGHT (TNFSF14) interaction with LTβR (constitutively expressed on human BM-MSCs) increases survival and proliferation of mesenchymal stem cells by upregulating cyclins B1, D1, D3, E and CDK1/CDK2, while decreasing p27, via PDGF and TGFβ production mediated by STAT3 and Smad3 activation. rhLIGHT treatment, cell viability/proliferation assays, cell cycle analysis, ELISA (PDGF, TGFβ), immunoblotting (cyclins, CDKs, p27, STAT3, Smad3) PloS one Medium 27835685
2010 Forced expression of LIGHT in tumors increases IFN-γ and chemoattractant cytokines (IL-1α, MIG, MIP-2) within the tumor, increases tumor-infiltrating CD8+ T cells, and expands functional T cells recognizing multiple tumor antigens including HPV16 E7. LIGHT expression establishes lymphoid-like tissue inside tumor sites and recruits naïve T cells. Adenoviral LIGHT overexpression in tumors, cytokine measurement, flow cytometry for TIL, T-cell functional assays, tumor challenge models Cancer research Medium 20460520
2019 Genetic inactivation of LIGHT (Tnfsf14-/-) in mice fed a high-fat high-cholesterol diet improves glucose tolerance and insulin sensitivity, reduces hepatic inflammation and NAFLD activity score, and is associated with decreased hepatic Zbtb16, Klf6, and Tlr4 expression. HVEM and LTβR were markedly increased in livers of HFHCD-fed wild-type mice, indicating upregulated LIGHT signaling. LIGHT deficiency altered adipose tissue macrophage polarization (increased anti-inflammatory F4/80+CD206+ and decreased proinflammatory F4/80+CD11c+ macrophages). Tnfsf14-/- knockout mouse model, glucose tolerance and insulin sensitivity tests, histology (NAS scoring), flow cytometry, hepatic gene expression analysis Diabetologia High 31388695
2020 In a mouse model of NSCLC bone metastasis (intratibial LLC-1 implantation), wild-type mice showed increased osteoclasts and reduced osteoblasts, while Tnfsf14-/- mice showed no significant bone loss or changes in bone homeostasis, demonstrating LIGHT is required for osteolytic bone metastasis-driven bone remodeling. Intratibial tumor implantation in WT and Tnfsf14-/- mice, histomorphometry, osteoclast/osteoblast counting, RANKL/anti-LIGHT blocking in PBMC cultures Journal of bone and mineral research High 31826304
2023 LIGHT (TNFSF14) promotes cardiac fibrosis and atrial fibrillation vulnerability by promoting macrophage M2 polarization and TGF-β1 secretion via PI3Kγ/SGK1 pathway activation. Recombinant LIGHT treatment of bone marrow-derived macrophages activates PI3Kγ/SGK1, and conditioned medium from these macrophages increases collagen synthesis and myofibroblast transition in cardiac fibroblasts; both effects were inhibited by PI3Kγ and SGK1 inhibitors. In vivo rLIGHT injection in mice, in vitro BMDM stimulation, macrophage conditioned medium on cardiac fibroblasts, PI3Kγ/SGK1 inhibitors, RNA sequencing, atrial burst pacing for AF inducibility, MASSON staining Journal of translational medicine High 37580750
2023 LIGHT (TNFSF14) co-expressed on CAR-T cells enhances cytotoxicity and cytokine production, promotes CCL19 and CCL21 expression in surrounding cells, and improves T cell migration in a paracrine manner. LIGHT CAR-T cells showed superior anti-tumor efficacy and improved intratumoral infiltration in NSG mice, and murine LIGHT-OT-1 T cells normalized tumor blood vessels and enforced intratumoral lymphoid structures in syngeneic tumor models. In vitro cytotoxicity assays, cytokine/chemokine measurement, T cell migration assays, xenograft (NSG) and syngeneic mouse tumor models Molecular therapy Medium 37408308
2019 miR-326 targets TNFSF14 (as validated by molecular target identification experiments), and miR-326-mediated suppression of TNFSF14 dampens pulmonary inflammation in silica-induced fibrosis. TNFSF14 is identified as a direct downstream target of miR-326 controlling the inflammatory response. Luciferase reporter/target validation assay, miR-326 overexpression in mouse fibrosis model, western blot, immunofluorescence Chemical research in toxicology Medium 31642316

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 Sensing and responding to excess light. Annual review of plant biology 645 19575582
2005 Mutations induced by ultraviolet light. Mutation research 539 15748635
2012 Shining a light on xeroderma pigmentosum. The Journal of investigative dermatology 404 22217736
2005 Shedding light on ADAM metalloproteinases. Trends in biochemical sciences 371 15949939
2008 Old acetogens, new light. Annals of the New York Academy of Sciences 339 18378590
1999 Blue-light photoreceptors in higher plants. Annual review of cell and developmental biology 253 10611956
2013 Light-harvesting in photosystem I. Photosynthesis research 194 23645376
2018 Blue-Light Receptors for Optogenetics. Chemical reviews 193 29984995
1995 Using GFP to see the light. Trends in genetics : TIG 186 8585130
2014 Photochemistry of flavoprotein light sensors. Nature chemical biology 185 25229449
2013 Ultraviolet light and ocular diseases. International ophthalmology 183 23722672
2006 Actions of ultraviolet light on cellular structures. EXS 174 16383017
2009 Light, including ultraviolet. Journal of autoimmunity 157 20018479
2000 Plant blue-light receptors. Trends in plant science 136 10908878
2017 Shining a light on enzyme promiscuity. Current opinion in structural biology 126 29169066
2013 Light harvesting in photosystem II. Photosynthesis research 123 23595278
2003 Synchronization of the molecular clockwork by light- and food-related cues in mammals. Biological chemistry 121 12817467
1999 Targeting expression with light using caged DNA. The Journal of biological chemistry 120 10409633
1981 Light chain nephropathy. The American journal of medicine 118 6789678
1997 New light on TRP and TRPL. Molecular pharmacology 113 9351965
2011 Plants under continuous light. Trends in plant science 110 21396878
2018 Shedding light on shedders. Forensic science international. Genetics 106 29902671
2001 DNA repair: spot(light)s on chromatin. Current biology : CB 104 11301269
2001 Blue light adaptation and desensitization of light signal transduction in Neurospora crassa. Molecular microbiology 102 11251826
1980 Polymorphous light eruption. Journal of the American Academy of Dermatology 100 7000864
2008 Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways. Immunological reviews 99 18613837
2007 Shedding light on Merlin's wizardry. Trends in cell biology 93 17442573
2016 Light-induced actuating nanotransducers. Proceedings of the National Academy of Sciences of the United States of America 87 27140648
2006 Marine cyanophages and light. Environmental microbiology 86 17107549
2005 Green light for the cell cycle. The EMBO journal 86 15678103
2006 Plastid biogenesis, between light and shadows. Journal of experimental botany 84 17108152
2022 Rhodopsin, light-sensor of vision. Progress in retinal and eye research 83 36273969
2020 Conditionally Activatable Visible-Light Photocages. Journal of the American Chemical Society 76 32786783
2001 Phycomyces and the biology of light and color. FEMS microbiology reviews 74 11742688
2010 CXCR3 binding chemokine and TNFSF14 over expression in bladder urothelium of patients with ulcerative interstitial cystitis. The Journal of urology 73 20096889
2021 Perspectives on improving light distribution and light use efficiency in crop canopies. Plant physiology 67 33631812
2018 Light Chain Amyloidosis. Mediterranean journal of hematology and infectious diseases 66 29531659
1999 UV light and MSH receptors. Annals of the New York Academy of Sciences 66 10816644
2014 Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT. Proceedings of the National Academy of Sciences of the United States of America 63 25512551
1999 Light and death: photons and apoptosis. The journal of investigative dermatology. Symposium proceedings 63 10537002
2015 Biogenesis of light harvesting proteins. Biochimica et biophysica acta 61 25687893
2012 Phototropism: translating light into directional growth. American journal of botany 61 23152332
2006 Light signals and flowering. Journal of experimental botany 59 16980594
2023 LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity through reversing immunosuppressive tumor microenvironment. Molecular therapy : the journal of the American Society of Gene Therapy 57 37408308
2021 Shining a Light on Colibactin Biology. Toxins 57 34065799
2005 Light activated recombination. Journal of the American Chemical Society 57 16173704
2018 Bringing Light to Transcription: The Optogenetics Repertoire. Frontiers in genetics 55 30450113
2000 Light and immunomodulation. Annals of the New York Academy of Sciences 55 11268371
2019 Plant Glutathione Transferases and Light. Frontiers in plant science 54 30687349
2019 MiR-326 Inhibits Inflammation and Promotes Autophagy in Silica-Induced Pulmonary Fibrosis through Targeting TNFSF14 and PTBP1. Chemical research in toxicology 52 31642316
2018 TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β. Frontiers in immunology 52 29616048
2019 Light- and temperature-entrainable circadian clock in soybean development. Plant, cell & environment 51 31724182
2017 Seeing the light with BLUF proteins. Biophysical reviews 50 28510088
2010 Light relief: photochemistry and medicine. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 50 21082123
2014 LIGHT/TNFSF14 increases osteoclastogenesis and decreases osteoblastogenesis in multiple myeloma-bone disease. Oncotarget 49 25460501
2008 Integration of light and plastid signals. Current opinion in plant biology 49 18948058
2020 Light-Inducible Recombinases for Bacterial Optogenetics. ACS synthetic biology 48 31961670
2006 Phototropin and light-signaling in phototropism. Current opinion in plant biology 48 16870491
2009 Targeting the LIGHT-HVEM pathway. Advances in experimental medicine and biology 45 19760072
2020 Blue Light Protection, Part I-Effects of blue light on the skin. Journal of cosmetic dermatology 44 33247615
2015 Update on stereology for light microscopy. Cell and tissue research 44 25743692
2014 Bringing bioelectricity to light. Annual review of biophysics 43 24773017
2013 Identifying transudates misclassified by Light's criteria. Current opinion in pulmonary medicine 43 23508114
2018 Concepts in Light Microscopy of Viruses. Viruses 41 29670029
1990 Polymorphic light eruption. Photodermatology, photoimmunology & photomedicine 41 2091741
2010 Expression of LIGHT/TNFSF14 combined with vaccination against human papillomavirus Type 16 E7 induces significant tumor regression. Cancer research 39 20460520
2007 Platelet-associated LIGHT (TNFSF14) mediates adhesion of platelets to human vascular endothelium. Thrombosis and haemostasis 37 17938804
2018 Photophobia: When Light Hurts, a Review. Current neurology and neuroscience reports 36 30058044
2011 Chromatin remodelling in plant light signalling. Physiologia plantarum 36 21457270
2005 Constitutive expression and costimulatory function of LIGHT/TNFSF14 on human melanoma cells and melanoma-derived microvesicles. Cancer research 36 15833878
2011 LIGHT/TNFSF14 enhances adipose tissue inflammatory responses through its interaction with HVEM. FEBS letters 35 21236258
1995 Pupillary light reflex. Current opinion in ophthalmology 35 10160414
2020 LIGHT/TNFSF14 Promotes Osteolytic Bone Metastases in Non-small Cell Lung Cancer Patients. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 34 31826304
2020 Genetics in Light of Transcriptional Adaptation. Trends in genetics : TIG 34 32928563
2018 Ultraviolet light and melanoma. The Journal of pathology 34 29380860
2018 Toward Light-Regulated Living Biomaterials. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 33 30128245
2023 TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation. Journal of translational medicine 32 37580750
2019 Genetic inactivation of the LIGHT (TNFSF14) cytokine in mice restores glucose homeostasis and diminishes hepatic steatosis. Diabetologia 31 31388695
2008 Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure. European journal of heart failure 30 18353719
2022 Ultraviolet Light Protection: Is It Really Enough? Antioxidants (Basel, Switzerland) 29 36009203
2020 Light Processable Starch Hydrogels. Polymers 28 32560332
2000 Phytochromes as light-modulated protein kinases. Seminars in cell & developmental biology 28 11145876
2013 Shedding LIGHT (TNFSF14) on the tumor microenvironment of colorectal cancer liver metastases. Journal of translational medicine 27 23514280
2012 Elevated plasma levels and platelet-associated expression of the pro-thrombotic and pro-inflammatory protein, TNFSF14 (LIGHT), in sickle cell disease. British journal of haematology 27 22775554
2020 Controlling PROTACs with Light. ChemMedChem 26 32558301
2019 Controlling protein conformation with light. Current opinion in structural biology 25 30849716
2016 Molecular mechanism of phototropin light signaling. Journal of plant research 25 26815763
2023 Photosystems under high light stress: throwing light on mechanism and adaptation. Photosynthetica 24 39650670
2015 Light-Triggered RNA Annealing by an RNA Chaperone. Angewandte Chemie (International ed. in English) 24 25959666
2021 A Light-Oxygen-Voltage Receptor Integrates Light and Temperature. Journal of molecular biology 23 34146595
2018 TNFSF14/LIGHT, a Non-Canonical NF-κB Stimulus, Induces the HIF Pathway. Cells 23 30096845
2024 Systemic inflammatory cytokine profiles in patients with gout during flare, intercritical and treat-to-target phases: TNFSF14 as new biomarker. Annals of the rheumatic diseases 22 38373842
2021 Plasma TNFSF13B and TNFSF14 Function as Inflammatory Indicators of Severe Adenovirus Pneumonia in Pediatric Patients. Frontiers in immunology 21 33542721
2021 Light and Skin. Current problems in dermatology 21 34698038
2013 Can osteoarthritis be treated with light? Arthritis research & therapy 21 24286607
2020 KIT ligand protects against both light-induced and genetic photoreceptor degeneration. eLife 20 32242818
2016 LIGHT (TNFSF14) Increases the Survival and Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells. PloS one 20 27835685
2011 HP1c casts light on dark matter. Cell cycle (Georgetown, Tex.) 20 21301224
2009 Brx shines a light on the route from hyperosmolarity to NFAT5. Science signaling 20 19351952
2007 Shining light on lupus and UV. Arthritis research & therapy 20 17284304

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