Affinage

TMEM201

Transmembrane protein 201 · UniProt Q5SNT2

Length
666 aa
Mass
72.2 kDa
Annotated
2026-06-10
72 papers in source corpus 11 papers cited in narrative 11 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TMEM201 (SAMP1/NET5) is an integral inner nuclear membrane protein that serves as a hub linking the nuclear envelope to the cytoskeleton, the Ran GTPase system, and signaling pathways governing cell migration, division, and differentiation (PMID:22349700, PMID:27541860). Its nucleoplasmically exposed N-terminal tail contains four conserved CxxC zinc-finger motifs that are required for inner nuclear membrane targeting, and its anchoring at the nuclear envelope depends on the A-type lamina (lamin A/C) (PMID:21610090, PMID:30326651). Through this N-terminal domain TMEM201 binds RanGTP preferentially over RanGDP and concentrates Ran at the nuclear periphery (PMID:27541860); RanGTP in turn weakens the TMEM201–emerin interaction, so that TMEM201 attenuates emerin mobility within the nuclear envelope (PMID:29510091). TMEM201 associates with the LINC complex proteins SUN1 and SUN2 and is a component of TAN lines together with nesprin-2G, coupling the nucleus to actin to drive nuclear movement during fibroblast polarization and migration (PMID:22349700, PMID:21610090), and the same LINC-dependent activity is required for endothelial migration and angiogenesis in vitro and in vivo (PMID:35311970). Beyond interphase, TMEM201 relocalizes to the mitotic spindle, binds γ-tubulin directly and the HAUS6 Augmin subunit, and is required to recruit them to the spindle for proper chromosome segregation (PMID:29514856). It also maintains peripheral heterochromatin (PMID:30793190) and acts in signaling: it is required for SMAD2/3 phosphorylation, nuclear translocation, and TGFβ target-gene activation supporting breast cancer EMT and invasion (PMID:34799661), and it is essential for myoblast differentiation, where its loss elevates ERK signaling and blocks myotube formation (PMID:29192166). Consistent with its lamin dependence, TMEM201 is mislocalized from myotube nuclear poles in LMNA-mutant Emery-Dreifuss muscular dystrophy in a manner requiring farnesylated prelamin A (PMID:30326651).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2011 High

    Established TMEM201 as a bona fide inner nuclear membrane protein physically and functionally coupled to the LINC complex and A-type lamins, defining its core localization machinery.

    Evidence siRNA knockdown, co-immunoprecipitation, deletion/CxxC mutagenesis and microscopy in fibroblasts; TAN-line component analysis

    PMID:21610090 PMID:22349700

    Open questions at the time
    • The structural basis of CxxC-mediated INM retention is not resolved
    • Whether SUN1/SUN2 binding is direct or lamin-bridged is not distinguished
  2. 2016 High

    Identified TMEM201 as a direct RanGTP-binding INM protein, connecting it to the nucleocytoplasmic Ran gradient and mapping the binding to its N-terminal tail (aa 75–135).

    Evidence Recombinant pulldown with human Ran and Chaetomium thermophilum Samp1, RanGTP/GDP discrimination, domain mapping, microscopy in tsBN2 cells

    PMID:27541860

    Open questions at the time
    • Functional consequence of peripheral Ran enrichment was not defined in this study
    • No structure of the Ran–TMEM201 interface
  3. 2018 High

    Linked the Ran-binding activity to regulation of a partner, showing RanGTP weakens TMEM201–emerin binding and that TMEM201 restrains emerin mobility in the nuclear envelope.

    Evidence FRAP in knockout and overexpressing cells plus in vitro binding with Ran

    PMID:29510091

    Open questions at the time
    • Physiological output of emerin mobility control was not established
    • Stoichiometry of the Ran-regulated complex unknown
  4. 2018 High

    Revealed an unexpected mitotic role: TMEM201 moves to the spindle and recruits γ-tubulin and the Augmin subunit HAUS6 to ensure faithful chromosome segregation.

    Evidence Live-cell imaging, siRNA knockdown/rescue, in vitro direct γ-tubulin binding, co-IP

    PMID:29514856

    Open questions at the time
    • How an INM protein accesses the spindle after NE breakdown is unexplained
    • Direct vs Augmin-bridged γ-tubulin recruitment not fully separated
  5. 2017 High

    Demonstrated a differentiation function, with TMEM201 required for myogenesis through suppression of ERK signaling.

    Evidence Stable shRNA in C2C12 cells, differentiation and marker assays, ERK analysis, RNAi-resistant rescue

    PMID:29192166

    Open questions at the time
    • Mechanistic link between TMEM201 and ERK regulation is undefined
    • Whether the role is INM-dependent was not tested
  6. 2018 Medium

    Placed TMEM201 in the molecular pathology of laminopathy, showing its nuclear-pole anchorage requires farnesylated prelamin A and is lost in EDMD2.

    Evidence Immunofluorescence in EDMD2 patient myotubes, pharmacological farnesylation inhibition, SUN1 vs LMNA epistasis

    PMID:30326651

    Open questions at the time
    • No in vitro reconstitution of prelamin A–TMEM201 anchorage
    • Causal contribution of TMEM201 mislocalization to disease phenotype untested
  7. 2019 Medium

    Extended TMEM201 function to chromatin architecture, implicating it in maintaining peripheral heterochromatin.

    Evidence FRIC ratiometric live-cell imaging with TMEM201 level manipulation

    PMID:30793190

    Open questions at the time
    • Effect on chromatin is indirect via a single imaging readout
    • Molecular tethering mechanism to heterochromatin unknown
  8. 2021 Medium

    Connected TMEM201 to a signaling cascade, showing it physically binds SMAD2/3 and is required for SMAD phosphorylation, nuclear translocation, and TGFβ-driven invasion.

    Evidence Co-IP, shRNA knockdown, RNA-seq, phospho-SMAD Western blot, migration/invasion and xenograft assays in breast cancer

    PMID:34799661

    Open questions at the time
    • Whether SMAD2/3 binding is direct or complex-mediated not resolved
    • How an INM protein influences cytoplasmic SMAD phosphorylation is unexplained
  9. 2022 High

    Provided in vivo validation that LINC-complex-dependent TMEM201 function drives endothelial migration and angiogenesis across species.

    Evidence shRNA in HUVECs, tube/sprouting/migration assays, Tmem201 knockout mice, zebrafish loss-of-function, N-terminal domain mapping

    PMID:35311970

    Open questions at the time
    • Downstream effectors of LINC-mediated endothelial motility not defined
    • Cell-autonomous vs systemic contribution in vivo not fully dissected
  10. 2025 Medium

    Implicated TMEM201 in metabolic regulation, proposing it facilitates Importin-α-dependent PKA nuclear import to drive CREB-mediated gluconeogenic transcription.

    Evidence Co-IP, AAV8 hepatocyte gain/loss-of-function in mice, primary hepatocytes, KG-501 epistasis (preprint)

    PMID:bio_10.1101_2025.11.17.688768

    Open questions at the time
    • Preprint, not yet peer-reviewed
    • Direct PKA import role versus indirect effect not established
    • Whether the Importin-α interaction is direct unconfirmed

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown how a single INM-anchored protein mechanistically integrates its RanGTP-, LINC-, lamin-, and partner-binding activities across such diverse processes, and no high-resolution structure of its N-terminal interaction domain exists.
  • No structural model of the CxxC/Ran-binding domain
  • No unifying mechanism connecting interphase, mitotic, and signaling roles

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 2 GO:0008092 cytoskeletal protein binding 2 GO:0060089 molecular transducer activity 2
Localization
GO:0005635 nuclear envelope 3 GO:0005634 nucleus 2
Pathway
R-HSA-1266738 Developmental Biology 2 R-HSA-162582 Signal Transduction 1 R-HSA-1640170 Cell Cycle 1
Partners
EMDHAUS6LMNARANSMAD2SUN1SUN2TUBG1
Complex memberships
LINC complexTAN lines

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2011 Samp1 (TMEM201/NET5) localizes to the inner nuclear membrane and is required for nuclear movement during fibroblast polarization and migration. Samp1 is a component of TAN (transmembrane actin-associated nuclear) lines containing nesprin-2G and SUN2. Samp1 associates with SUN2 and lamin A/C, and its presence at the nuclear envelope requires lamin A/C. siRNA knockdown, fluorescence microscopy, co-immunoprecipitation, fibroblast polarization/migration assays Journal of cell science High 22349700
2011 Samp1 (TMEM201) is an inner nuclear membrane protein whose nucleoplasmically exposed N-terminal cysteine-rich region (containing four conserved CxxC zinc-finger motifs) is responsible for INM targeting. Intact CxxC motifs are required for NE localization. Samp1 colocalizes partially with Sun1 and functionally associates with the LINC complex protein Sun1 and the A-type lamina network. Samp1 depletion causes mislocalization of emerin, Sun1, and endogenous Samp1, but not lamin B, Sun2, or nucleoporins. Deletion mutant and fusion protein localization, cysteine-to-alanine substitution mutagenesis, siRNA knockdown, high-resolution fluorescence microscopy Journal of cell science High 21610090
2018 Samp1 (TMEM201) localizes to the mitotic spindle during mitosis and is required for mitotic spindle assembly. Samp1 depletion increases chromosomal mis-segregation frequency and prolongs metaphase. Samp1 binds directly to γ-tubulin and co-precipitates with γ-tubulin and the HAUS6 subunit of the Augmin complex. Samp1 is required for recruitment of HAUS6 and γ-tubulin to the mitotic spindle. Live-cell imaging, siRNA knockdown, in vitro direct binding assay, co-immunoprecipitation, rescue by overexpression of RNAi-resistant Samp1a-YFP Journal of cell science High 29514856
2016 Samp1 (TMEM201) is a RanGTP-binding transmembrane protein of the inner nuclear membrane. Pulldown experiments using recombinant Chaetomium thermophilum Samp1 and human Ran showed direct binding, with preference for RanGTP over RanGDP. The Ran-binding domain maps to amino acids 75–135 in the nucleoplasmically exposed N-terminal tail of Samp1. Samp1 overexpression increases Ran concentration at the nuclear periphery. Recombinant protein pulldown, in vitro binding assay with RanGTP/RanGDP, domain mapping, fluorescence microscopy in tsBN2 cells Nucleus (Austin, Tex.) High 27541860
2018 RanGTP regulates the interaction between Samp1 (TMEM201) and emerin in the inner nuclear membrane. FRAP experiments showed that emerin mobility in the NE is increased in Samp1 knockout cells and decreased in Samp1-overexpressing cells, indicating Samp1 attenuates emerin mobility. In vitro binding experiments showed that Ran decreases the affinity between Samp1 and emerin, establishing that RanGTP attenuates the Samp1–emerin interaction. FRAP in live cells, Samp1 knockout and overexpression, in vitro binding assay with Ran Biochimica et biophysica acta. Biomembranes High 29510091
2017 Samp1 (TMEM201) is required for differentiation of muscle cells (myogenesis). Samp1 levels increase seven-fold during C2C12 myoblast differentiation. Stable shRNA-mediated Samp1 depletion completely blocks myotube formation and expression of myogenic marker proteins, and increases ERK signaling. The differentiation block is rescued by ectopic expression of RNAi-resistant human Samp1. Stable shRNA knockdown in C2C12 cells, myogenic differentiation assay, Western blotting for myogenic markers, ERK signaling analysis, rescue experiment Scientific reports High 29192166
2018 In Emery-Dreifuss muscular dystrophy (EDMD2) caused by LMNA mutations, Samp1 is mislocalized from nuclear poles of myotubes. Samp1 anchorage at nuclear poles in normal myotubes depends on farnesylated prelamin A; loss of prelamin A farnesylation disrupts this anchorage. Pathogenic SUN1 mutations do not alter Samp1 localization, placing Samp1 upstream of SUN1 in nuclear envelope protein complexes. Immunofluorescence in EDMD2 patient myotubes, pharmacological inhibition of prelamin A farnesylation, genetic epistasis (SUN1 vs LMNA mutations) Cells Medium 30326651
2019 Samp1 (TMEM201) promotes peripheral heterochromatin organization. Using the FRIC (Fluorescence Ratiometric Imaging of Chromatin) live-cell assay, reduction of Samp1 levels was found to decrease peripheral heterochromatin, indicating Samp1 plays a role in maintaining heterochromatin at the nuclear periphery. FRIC live-cell imaging, Samp1 level manipulation (knockdown/overexpression), ratiometric chromatin distribution quantification Nucleic acids research Medium 30793190
2021 TMEM201 (Samp1) physically interacts with SMAD2/3 and is required for phosphorylation of SMAD2/3, nuclear translocation of SMAD2/3, and transcriptional activation of TGFβ target genes. TMEM201 deficiency inhibits epithelial-to-mesenchymal transition and TGFβ signaling. TMEM201 acts as a positive modulator of TGFβ/SMAD signaling necessary for breast cancer cell migration and invasion. Co-immunoprecipitation (physical interaction with SMAD2/3), shRNA knockdown, RNA-sequencing, Western blotting for phospho-SMAD2/3, in vitro migration/invasion assays, in vivo xenograft Oncogene Medium 34799661
2022 TMEM201 (Samp1) interacts with the LINC complex via its N-terminal domain and is required for endothelial cell migration and angiogenesis. Depletion of TMEM201 impairs tube formation, sprouting, and migration of HUVECs in vitro. In vivo, Tmem201-knockout mice show arrested retinal vessel development and defective aortic ring sprouting; loss of tmem201 in zebrafish impairs intersegmental vessel development. shRNA knockdown in HUVECs, tube formation and fibrin gel bead sprouting assays, migration assays, Tmem201 knockout mice (retinal vessel and aortic ring assays), zebrafish morpholino/knockout, N-terminal domain interaction mapping Journal of molecular cell biology High 35311970
2025 SAMP1/TMEM201 promotes hepatic gluconeogenesis by interacting with Importin-α and facilitating nuclear translocation of PKA, thereby enhancing CREB phosphorylation and transcription of gluconeogenic genes (Pck1, G6pc). SAMP1 is upregulated in db/db diabetic mice livers. AAV8-mediated hepatocyte-specific SAMP1 overexpression exacerbated hyperglycemia and glucose intolerance; SAMP1 knockdown attenuated these effects. The effect is abolished by the CREB inhibitor KG-501. Co-immunoprecipitation (SAMP1–Importin-α interaction), AAV8-mediated gain- and loss-of-function in vivo, primary hepatocyte in vitro experiments, Western blotting, ELISA, pharmacological inhibition with KG-501 bioRxivpreprint Medium bio_10.1101_2025.11.17.688768

Source papers

Stage 0 corpus · 72 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. Gut 100 16682432
2012 Samp1 is a component of TAN lines and is required for nuclear movement. Journal of cell science 86 22349700
2005 Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn's disease. Gastroenterology 73 15685547
2011 Inner nuclear membrane protein Ima1 is dispensable for intranuclear positioning of centromeres. Genes to cells : devoted to molecular & cellular mechanisms 54 21880100
2003 Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's disease: SAMP1/YitFc. Gastroenterology 52 12891551
2005 In vivo demonstration of T lymphocyte migration and amelioration of ileitis in intestinal mucosa of SAMP1/Yit mice by the inhibition of MAdCAM-1. Clinical and experimental immunology 49 15762871
2012 The inner nuclear membrane proteins Man1 and Ima1 link to two different types of chromatin at the nuclear periphery in S. pombe. Nucleus (Austin, Tex.) 48 22156748
2011 Samp1 is functionally associated with the LINC complex and A-type lamina networks. Journal of cell science 48 21610090
2005 Altered epithelial cell lineage allocation and global expansion of the crypt epithelial stem cell population are associated with ileitis in SAMP1/YitFc mice. The American journal of pathology 40 15793286
2004 Blockade of PSGL-1 attenuates CD14+ monocytic cell recruitment in intestinal mucosa and ameliorates ileitis in SAMP1/Yit mice. Journal of leukocyte biology 39 15569697
2000 Sensitivity of the olfactory sense declines with the aging in senescence-accelerated mouse (SAM-P1). Physiology & behavior 34 10978488
2009 Mechanisms of tight junction dysregulation in the SAMP1/YitFc model of Crohn's disease-like ileitis. Annals of the New York Academy of Sciences 32 19538320
2007 Resistin-like molecule beta (RELMbeta/FIZZ2) is highly expressed in the ileum of SAMP1/YitFc mice and is associated with initiation of ileitis. Journal of immunology (Baltimore, Md. : 1950) 32 17982092
2004 Interleukin-5 participates in the pathogenesis of ileitis in SAMP1/Yit mice. European journal of immunology 32 15162425
2013 Dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America 30 24082103
2010 Decreased production of interleukin-10 and transforming growth factor-β in Toll-like receptor-activated intestinal B cells in SAMP1/Yit mice. Immunology 30 20561083
2011 Crystal structure of ubiquitin-like small archaeal modifier protein 1 (SAMP1) from Haloferax volcanii. Biochemical and biophysical research communications 24 21216237
2010 Beta7 integrin deficiency suppresses B cell homing and attenuates chronic ileitis in SAMP1/YitFc mice. Journal of immunology (Baltimore, Md. : 1950) 22 20926792
1987 A molecular-pathologic approach to murine senile amyloidosis. Serum precursor-apolipoprotein A-II variant (Pro5----Gln) presents only in the senile amyloidosis-prone SAM-P/1 and SAM-P/2 mice. Laboratory investigation; a journal of technical methods and pathology 22 3298851
2015 SAMP1/YitFc mice develop ileitis via loss of CCL21 and defects in dendritic cell migration. Gastroenterology 21 25620669
2019 Submandibular gland-specific inflammaging-induced hyposalivation in the male senescence-accelerated mouse prone -1 line (SAM-P1). Biogerontology 20 30684147
2018 Death Receptor 3 Signaling Controls the Balance between Regulatory and Effector Lymphocytes in SAMP1/YitFc Mice with Crohn's Disease-Like Ileitis. Frontiers in immunology 20 29545797
2010 The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice. IUBMB life 20 21086475
2018 Mitotic spindle assembly and γ-tubulin localisation depend on the integral nuclear membrane protein Samp1. Journal of cell science 19 29514856
2016 Industrial textile effluent decolourization in stirred and static batch cultures of a new fungal strain Chaetomium globosum IMA1 KJ472923. Journal of environmental management 18 26775156
2012 Age-related decline of mast cell regeneration in senescence-accelerated mice (SAMP1) after chemical myeloablation due to senescent stromal cell impairment. Experimental biology and medicine (Maywood, N.J.) 18 23239440
2011 Spontaneous, immune-mediated gastric inflammation in SAMP1/YitFc mice, a model of Crohn's-like gastritis. Gastroenterology 16 21704001
2010 Elevated expression of Paneth cell CRS4C in ileitis-prone SAMP1/YitFc mice: regional distribution, subcellular localization, and mechanism of action. The Journal of biological chemistry 15 20056603
2019 Long-Term Intake of Glucoraphanin-Enriched Kale Suppresses Skin Aging via Activating Nrf2 and the TβRII/Smad Pathway in SAMP1 Mice. Journal of agricultural and food chemistry 14 31390859
2018 Analysis of aging-dependent changes in taste sensitivities of the senescence-accelerated mouse SAMP1. Experimental gerontology 14 30243894
2018 Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming in SAMP1/kl (-/-) mice. Aging 12 30222592
2017 A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis. PloS one 12 28301579
2015 Ubiquitin-Like Protein SAMP1 and JAMM/MPN+ Metalloprotease HvJAMM1 Constitute a System for Reversible Regulation of Metabolic Enzyme Activity in Archaea. PloS one 12 26010867
2008 Role of hematopoietic microenvironment in prolonged impairment of B cell regeneration in age-related stromal-cell-impaired SAMP1 mouse: effects of a single dose of 5-fluorouracil. Journal of applied toxicology : JAT 12 18344199
2021 Inner nuclear membrane protein TMEM201 promotes breast cancer metastasis by positive regulating TGFβ signaling. Oncogene 11 34799661
2019 Senescence-accelerated mice (SAMP1/TA-1) treated repeatedly with lipopolysaccharide develop a condition that resembles hemophagocytic lymphohistiocytosis. Haematologica 11 30819910
2018 Inhibition of autotaxin alleviates inflammation and increases the expression of sodium-dependent glucose cotransporter 1 and Na+/H+ exchanger 3 in SAMP1/Fc mice. American journal of physiology. Gastrointestinal and liver physiology 11 30118349
2021 Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice. International journal of molecular sciences 10 33401680
2005 SAMP1/Sku as a murine model for tubulointerstitial nephritis: a study using unilateral ureteral obstruction. Experimental animals 10 15725681
2023 Characterization of the Clinical Significance and Immunological Landscapes of a Novel TMEMs Signature in Hepatocellular Carcinoma and the Contribution of TMEM201 to Hepatocarcinogenesis. International journal of molecular sciences 9 37373430
2021 Depletion of Intestinal Stem Cell Niche Factors Contributes to the Alteration of Epithelial Differentiation in SAMP1/YitFcsJ Mice With Crohn Disease-Like Ileitis. Inflammatory bowel diseases 9 33274375
2018 Samp1 Mislocalization in Emery-Dreifuss Muscular Dystrophy. Cells 9 30326651
2022 Effects of ionic strength on the folding and stability of SAMP1, a ubiquitin-like halophilic protein. Biophysical journal 8 35063455
2002 Insufficient interleukin-2 production from splenic CD4+ T cells causes impaired cell proliferation and early apoptosis in SAMP1, a strain of senescence-accelerated mouse. Immunology 8 12383198
2020 Inducible Nitric Oxide Regulates Na-Glucose Co-transport in a Spontaneous SAMP1/YitFc Mouse Model of Chronic Ileitis. Nutrients 7 33065982
2018 RanGTPase regulates the interaction between the inner nuclear membrane proteins, Samp1 and Emerin. Biochimica et biophysica acta. Biomembranes 7 29510091
2017 Spindle associated membrane protein 1 (Samp1) is required for the differentiation of muscle cells. Scientific reports 7 29192166
2013 Spontaneous occurrence of photoageing-like phenotypes in the dorsal skin of old SAMP1 mice, an oxidative stress model. Experimental dermatology 7 23278896
2022 Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex. Journal of molecular cell biology 6 35311970
2021 Mast Cell Mediated Regulation of Small Intestinal Chloride Malabsorption in SAMP1/YitFc Mouse Model of Spontaneous Chronic Ileitis. Cells 6 33801010
2019 Monitoring of chromatin organization in live cells by FRIC. Effects of the inner nuclear membrane protein Samp1. Nucleic acids research 6 30793190
2022 Genomic and transcriptomic-based analysis of agronomic traits in sugar beet (Beta vulgaris L.) pure line IMA1. Frontiers in plant science 5 36311117
2013 Ionic strength-dependent conformations of a ubiquitin-like small archaeal modifier protein (SAMP1) from Haloferax volcanii. Protein science : a publication of the Protein Society 5 23818097
2012 Neopterin, inflammation-associated product, prolongs erythropoiesis suppression in aged SAMP1 mice due to senescent stromal-cell impairment. Experimental biology and medicine (Maywood, N.J.) 5 22442357
2002 Life span and renal morphological characterization of the SAMP1//Ka mouse. Experimental animals 5 11871156
2021 Comparison between the timing of the occurrence of taste sensitivity changes and short-term memory decline due to aging in SAMP1 mice. PloS one 4 33755681
2021 Unique Regulation of Coupled NaCl Absorption by Inducible Nitric Oxide in a Spontaneous SAMP1/YitFc Mouse Model of Chronic Intestinal Inflammation. Inflammatory bowel diseases 4 34019094
2015 Dysregulated intrahepatic CD4+ T-cell activation drives liver inflammation in ileitis-prone SAMP1/YitFc mice. Cellular and molecular gastroenterology and hepatology 4 26213712
2000 Wild type ApoA-II gene does not rescue senescence-accelerated mouse (SAMP1) from short life span and accelerated mortality. The journals of gerontology. Series A, Biological sciences and medical sciences 4 10995040
2022 Ascorbic acid induces salivary gland function through TET2/acetylcholine receptor signaling in aging SAMP1/Klotho (-/-) mice. Aging 3 35951355
2016 Samp1, a RanGTP binding transmembrane protein in the inner nuclear membrane. Nucleus (Austin, Tex.) 3 27541860
2000 Genetic analysis of lifespan in hybrid progeny derived from the SAMP1 mouse strain with accelerated senescence. Mechanisms of ageing and development 3 10989123
2018 Publisher Correction: Spindle associated membrane protein 1 (Samp1) is required for the differentiation of muscle cells. Scientific reports 2 29515148
2011 Pathogenesis of gastritis in ileitis-prone SAMP1/Yit mice. The Keio journal of medicine 2 21720202
2008 [Response of the spermatogenic system to chemical mutagen dipin in SAMP1 senesce-accelerated mice]. Izvestiia Akademii nauk. Seriia biologicheskaia 1 18663966
2008 [Estimation of the frequencies of induced mutations in spermatogenic cells of senescence-accelerated prone mice of the SAMP1 strain]. Genetika 1 19137738
2003 Production of age-related DNA strand breakage in brain cells of senescence-accelerated prone (SAMP1) mouse. Experimental animals 1 14562614
1998 Low sucrase activity in the small intestine of a senescence-accelerated strain of mouse, SAMP1. Bioscience, biotechnology, and biochemistry 1 9648228
2026 TMEM201 regulates tumor malignancy and immune microenvironment in lower-grade glioma. BMC medical genomics 0 41555358
2017 Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice. Biochemical and biophysical research communications 0 28893537
2014 [Morphological changes of neurons and neuroglial cells in the brain of senescence-accelerated prone 1 (SAMP1) mice]. Arkhiv patologii 0 25051721
2011 Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice. American journal of physiology. Gastrointestinal and liver physiology 0 21921286

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