Affinage

TAB1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 · UniProt Q15750

Length
504 aa
Mass
54.6 kDa
Annotated
2026-06-10
100 papers in source corpus 44 papers cited in narrative 44 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TAB1 (MAP3K7IP1) is a scaffold/adaptor protein that activates stress- and cytokine-responsive MAP kinase signaling by directly engaging and allosterically activating two distinct kinases (PMID:8638164, PMID:11847341). Through a C-terminal alpha-helical domain bearing a conserved PYVDXA/TXF motif and the critical Phe484, TAB1 binds the TAK1 kinase domain via a complementary hydrophobic pocket and induces TAK1 autophosphorylation on activation-loop threonines (Thr187), thereby driving TAK1 catalytic activity toward downstream IKK/NF-kappaB and MAPK modules (PMID:10838074, PMID:11323434, PMID:15590691, PMID:16289117); TAB1 is essential in vivo, as Tab1-null embryos die with cardiovascular and lung defects and Tab1-null fibroblasts show abolished TAK1 activity after IL-1/TNF and reduced TGF-beta responsiveness (PMID:12464436, PMID:18021073), with TAB1 selectively required for osmotic stress- and TGF-beta-induced TAK1 activation rather than all cytokine inputs (PMID:18829460, PMID:19556242). Independently of upstream MAP2Ks, TAB1 binds p38alpha at a bipartite docking site on its C-terminal lobe (engaging p38alpha residues Thr218/Ile275 via a cryptic D-domain-like site near Pro412) and induces p38alpha autophosphorylation in cis, a conformational mechanism that stabilizes the active kinase and depends on p38alpha Thr185 (PMID:11847341, PMID:16648477, PMID:24037507, PMID:29229647). This non-canonical TAB1-p38alpha axis operates in myocardial ischemia, where AMPK promotes p38 recruitment to TAB1 to drive ischemic injury (PMID:12829618, PMID:16179588, PMID:30135318), in CD4+ T-cell anergy and senescence (PMID:15282297, PMID:25151490), and in GPCR signaling in endothelium (PMID:30760523). TAB1 activity is tuned by an extensive PTM network: activating O-GlcNAcylation at Ser395 (PMID:22307082), activating TRIM26-mediated K11-linked and RNF207-mediated K63-linked ubiquitination (PMID:34017102, PMID:35352799), inactivating DUSP14-mediated dephosphorylation at Ser438 (PMID:24403530), MEKK1-PHD- and Itch-mediated ubiquitination (PMID:25260751, PMID:25714464), and RNF114-driven degradation during the maternal-to-zygotic transition (PMID:28073917). TAB1 further links to NF-kappaB activation through direct interaction with the XIAP BIR1 domain and with IKKbeta (PMID:17560374, PMID:18316610), and viral proteases (EV71 3C, SARS-CoV-2 NSP5) cleave TAB1 to disrupt inflammatory signaling (PMID:24942571, PMID:33372854).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 1996 High

    Established TAB1 as a physical and functional activator of the TAK1 MAP3K, answering how TAK1 is engaged in TGF-beta-regulated transcription.

    Evidence Yeast two-hybrid, reciprocal co-IP, kinase assay and promoter reporter in mammalian cells

    PMID:8638164

    Open questions at the time
    • Did not define the binding interface or the molecular mechanism of activation
    • Did not establish in vivo requirement
  2. 2001 High

    Defined the structural basis of TAK1 engagement, mapping activation to a conserved C-terminal PYVDXA/TXF motif forming a unique alpha-helix with Phe484 as the critical contact.

    Evidence Deletion/alanine mutagenesis, NMR, co-IP and kinase assay; conservation validated in C. elegans

    PMID:10838074 PMID:11323434

    Open questions at the time
    • Atomic-resolution view of the TAK1 pocket not yet available
    • Did not address how stimulus specificity is achieved
  3. 2002 High

    Revealed a second, MAP2K-independent function: TAB1 directly binds p38alpha and induces its autophosphorylation, defining a non-canonical p38 activation route.

    Evidence Co-IP, in vitro kinase assay, dominant-negative/overexpression, TRAF6-TAB1-p38alpha ternary complex detection; splice-variant TAB1beta analysis

    PMID:11847341 PMID:12372426 PMID:12429732

    Open questions at the time
    • Mechanism of cis-autophosphorylation not yet resolved
    • p38alpha docking residues not yet mapped
  4. 2002 High

    Demonstrated the essential in vivo role of TAB1 for TAK1 activation and embryonic development.

    Evidence Tab1 knockout mice, embryo histology, kinase assay in null MEFs, TGF-beta signaling assay

    PMID:12464436

    Open questions at the time
    • Did not separate TAK1-dependent from p38-dependent developmental functions
    • Cell-type-specific requirements not addressed
  5. 2004 High

    Resolved the activating phosphorylation event (TAK1 Thr187 intermolecular autophosphorylation) and revealed feedback control by a p38alpha/TAB1/TAB2 loop.

    Evidence Phospho-specific immunoblotting, alanine mutagenesis, RNAi, kinase assay

    PMID:15590691

    Open questions at the time
    • Differential contributions of TAB1 vs TAB2 to TAK1 phosphorylation not fully separated
    • Feedback kinetics in physiological settings unclear
  6. 2005 High

    Provided the atomic structural basis for TAK1 activation, showing a TAK1-domain pocket complementary to the TAB1 alpha-helix.

    Evidence X-ray crystallography of a TAK1 chimeric protein

    PMID:16289117

    Open questions at the time
    • Used a chimeric construct rather than the native complex
    • Did not capture full-length regulatory regions
  7. 2005 High

    Linked the non-canonical TAB1-p38 axis to disease physiology, showing it drives ischemic p38 activation in myocardium and is potentiated by AMPK recruitment.

    Evidence mkk3-/- perfused hearts, AICAR/kinase-dead AMPK transgenic mice, co-IP, SB203580 pharmacology

    PMID:12829618 PMID:16179588

    Open questions at the time
    • How AMPK physically promotes p38-TAB1 assembly not structurally defined
    • Whether AMPK directly modifies TAB1 unresolved
  8. 2006 High

    Mapped the p38alpha docking determinants (TAB1 Pro412 cryptic D-site; p38alpha Thr218/Ile275) explaining isoform-specific TAB1-p38alpha engagement and revealed negative regulators (PKG I, cytoplasmic sequestration).

    Evidence Point/chimeric mutagenesis, co-IP, kinase assay, subcellular fractionation, cardiac PKG I knockout

    PMID:16407200 PMID:16648477 PMID:16943189

    Open questions at the time
    • Conformational mechanism of induced autophosphorylation still unresolved at this stage
    • Physiological balance between sequestration and activation unclear
  9. 2007 High

    Defined a structural NF-kappaB-activating input, showing the XIAP BIR1 domain dimer directly binds TAB1 to drive TAK1-dependent NF-kappaB activation.

    Evidence Crystallography of BIR1/TAB1 complex, SPR, structure-based mutagenesis, TAB1 knockdown, NF-kappaB reporter

    PMID:17560374

    Open questions at the time
    • In vivo significance of XIAP-TAB1 axis not established
    • How Smac antagonism is regulated physiologically unclear
  10. 2008 High

    Established TAB1 as an obligate scaffold for TAK1 catalysis and for recruiting p38alpha into the TAK1 complex, and defined stimulus-specific requirement (osmotic stress vs cytokines).

    Evidence Tab1-/- MEF kinase assays, MS phosphosite mapping of TAB3, osmotic stress and truncation analyses; IKKbeta complex and TAB4 phosphosite studies

    PMID:18021073 PMID:18316610 PMID:18456659 PMID:18829460

    Open questions at the time
    • Reconciliation with reports that TAK1/TAB1 are dispensable for some cytokine pathways incomplete
    • Quantitative stoichiometry of the scaffold complex unknown
  11. 2009 High

    Embedded the TAK1-TAB1 complex in a calcineurin-NFAT regulatory loop via RCAN1 phosphorylation, and showed TGF-beta activation of TAK1 occurs without receptor kinase activity.

    Evidence In vitro kinase assay with defined RCAN1 sites, co-IP, NFAT reporter, Tab2/Rcan-null MEFs; kinase-dead TbetaRI analysis

    PMID:19136967 PMID:19556242

    Open questions at the time
    • How TGF-beta signal reaches TAB1 without receptor binding unresolved
    • Tissue specificity of the calcineurin crosstalk unclear
  12. 2012 High

    Identified O-GlcNAcylation of TAB1 at Ser395 as a metabolic PTM required for full TAK1 activation and downstream cytokine output.

    Evidence O-GlcNAc antibody, S395A mutagenesis, Tab1-/- MEF reconstitution, kinase assay, ELISA

    PMID:22307082

    Open questions at the time
    • The O-GlcNAc transferase responsible not identified here
    • Structural effect of Ser395 modification on TAK1 binding unknown
  13. 2013 High

    Solved the cis-autophosphorylation mechanism: TAB1(371-416) docks a bipartite site on p38alpha, stabilizing active conformation and enabling intramolecular activation-loop phosphorylation.

    Evidence Crystallography of p38alpha-TAB1 complex, chemical-genetics, FRET, cardiac myocyte/perfused heart with TAT-TAB1 peptide; USP18 and MDM2/p53 regulatory studies

    PMID:23825189 PMID:23934659 PMID:24037507

    Open questions at the time
    • How docking is dynamically regulated by upstream stimuli unclear
    • Generality of the MDM2/p53 link across tissues unestablished
  14. 2014 High

    Extended the AMPK-TAB1-p38 axis to T-cell senescence and expanded the PTM regulatory layer (MEKK1-PHD K63 ubiquitination); identified pharmacological/viral disruption of TAB1.

    Evidence Co-IP and inhibitor studies in primary human T cells, protein microarray/in vitro ubiquitination, triptolide pull-down, EV71 3C cleavage assays

    PMID:24462677 PMID:24942571 PMID:25151490 PMID:25260751

    Open questions at the time
    • Direct physical AMPK-TAB1-p38 architecture not solved
    • In vivo relevance of MEKK1-PHD ubiquitination of TAB1 limited
  15. 2015 High

    Identified Itch as a ubiquitin ligase binding TAB1 via a PPXY motif to restrain p38alpha activation, with therapeutic peptide disruption of TAB1-p38 reducing inflammation.

    Evidence Co-IP, ubiquitination assay, shRNA, Itch-/- mice, reconstitution with ligase-dead Itch, cell-permeable peptide

    PMID:25714464

    Open questions at the time
    • Ubiquitination linkage type and target lysines on TAB1 not fully defined
    • Crosstalk with activating ubiquitin ligases unresolved
  16. 2018 High

    Provided definitive structural and genetic proof that TAB1-driven p38alpha cis-autophosphorylation mediates ischemic injury, via docking-site and Thr185-dependent conformational mechanisms.

    Evidence Crystallography of pp38alpha-TAB1(1-438), TAB1 and p38alpha T185G knock-in mice, in vivo regional ischemia

    PMID:29229647 PMID:30135318

    Open questions at the time
    • Residual MKK-dependent p38 activation complicates clean separation in vivo
    • Therapeutic targeting feasibility not yet established
  17. 2021 High

    Established activating K11-linked ubiquitination of TAB1 by TRIM26 as a driver of inflammatory TAK1 signaling with in vivo disease relevance.

    Evidence In vitro ubiquitination, site mutagenesis (K294/319/335), Trim26-KO and transgenic mice, septic shock and DSS colitis models

    PMID:34017102

    Open questions at the time
    • How K11 chains structurally promote TAK1 activation unclear
    • Interplay with other TAB1 ubiquitin ligases not mapped
  18. 2023 Medium

    Linked metabolic and ubiquitin signals to cardiac and tumor pathology through TAB1 (RNF207 K63 ubiquitination; GFAT1/TTLL5 glutamylation recruiting p38alpha for autophagy).

    Evidence Co-IP, in vitro ubiquitination, TAC mouse model, S438-dependent GFAT1 binding, TTLL5 glutamylation and autophagy assays

    PMID:35352799 PMID:35945223

    Open questions at the time
    • Single-lab findings without independent replication
    • Structural basis of glutamylation-driven p38alpha recruitment unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the diverse activating and inhibitory PTMs on TAB1 are integrated to set context-specific TAK1 versus p38alpha output remains unresolved.
  • No unified model reconciling competing ubiquitin, O-GlcNAc, glutamylation and phosphorylation marks
  • Quantitative determinants of TAB1 partitioning between TAK1 and p38alpha complexes unknown
  • Stoichiometry and dynamics of native TAB1 complexes in vivo undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 6 GO:0098772 molecular function regulator activity 5 GO:0060090 molecular adaptor activity 4
Localization
GO:0005634 nucleus 1 GO:0005829 cytosol 1
Pathway
R-HSA-168256 Immune System 5 R-HSA-162582 Signal Transduction 4 R-HSA-1266738 Developmental Biology 3 R-HSA-8953897 Cellular responses to stimuli 3
Partners
DUSP14IKBKBITCHMAP3K7MAPK14PRKAA2TRIM26XIAP
Complex memberships
TAK1-TAB1-TAB2 complexp38alpha-TAB1 complex

Evidence

Reading pass · 44 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 TAB1 was identified as a TAK1-binding protein via yeast two-hybrid screening; TAB1 and TAK1 co-immunoprecipitate from mammalian cells, and overproduction of TAB1 increases TAK1 kinase activity and enhances TGF-β-regulated promoter activity, establishing TAB1 as an activator of TAK1 MAPKKK. Yeast two-hybrid, co-immunoprecipitation, kinase activity assay, promoter reporter assay Science High 8638164
2000 TAB1 activates TAK1 through a phosphorylation-dependent mechanism: association between the TAK1 kinase domain and the C-terminal region of TAB1 (C-terminal 24 amino acids required for association; additional Ser/Thr-rich sequences required for full activation) induces TAK1 autophosphorylation on two threonine residues in its activation loop. In vitro kinase assay, deletion mutagenesis, co-immunoprecipitation FEBS letters High 10838074
2001 An evolutionarily conserved PYVDXA/TXF motif in the C-terminal 30 amino acids of TAB1 is necessary for TAK1 interaction and activation; NMR revealed this region forms a unique alpha-helical structure; Phe-484 within the conserved motif is critical for TAK1 binding. Deletion and alanine-substitution mutagenesis, NMR, co-immunoprecipitation, kinase assay The Journal of biological chemistry High 11323434
2002 TAB1 and TAK1 form a constitutively active complex when their minimal interacting domains are fused; the TAK1-TAB1 fusion protein shows intramolecular interaction (by co-IP), significant MAP3K activity in vitro, and activates JNK/p38 MAPKs and IKK in vivo, leading to IL-6 production. Co-immunoprecipitation, in vitro kinase assay, reporter assay, ELISA Biochemical and biophysical research communications Medium 12372426
2002 TAB1beta, a C-terminal splice variant of TAB1 lacking the TAK1-binding domain, interacts with p38alpha but not TAK1, and stimulates p38alpha autoactivation; knockdown of TAB1beta in MDA231 cells reduced basal p38alpha activity and cell invasiveness. Co-immunoprecipitation, kinase assay, RNA interference, invasion assay The Journal of biological chemistry Medium 12429732
2002 MAPKK-independent activation of p38alpha occurs via direct interaction with TAB1, leading to autophosphorylation and activation of p38alpha; a TRAF6-TAB1-p38alpha ternary complex was detected, and stimulus-specific TAB1-dependent and -independent p38alpha activation was demonstrated. Co-immunoprecipitation, in vitro kinase assay, dominant-negative and overexpression experiments Science High 11847341
2002 Targeted disruption of Tab1 in mice causes embryonic lethality with cardiovascular and lung dysmorphogenesis; Tab1-null embryonic fibroblasts display drastically reduced TAK1 kinase activity and decreased sensitivity to TGF-beta stimulation, demonstrating an essential in vivo role for TAB1 in TAK1 activation. Gene knockout (homologous recombination), embryo histology, in vitro kinase assay, TGF-beta signaling assay Mechanisms of development High 12464436
2003 TAK1/TAB1/NIK cascade mediates cytokine suppression of PPAR-gamma: IL-1 and TNF-alpha activate NF-kappaB through TAK1/TAB1/NIK, and activated NF-kappaB blocks PPAR-gamma DNA binding by forming a complex with PPAR-gamma and its co-activator PGC-2, thereby suppressing adipogenesis. Reporter assay, co-immunoprecipitation, dominant-negative overexpression, chromatin binding assay Nature cell biology Medium 12598905
2003 TAB1-associated p38alpha autophosphorylation mediates ischemic p38 activation in the myocardium independent of MKK3; in ischemic (but not TNF-exposed) hearts, p38-MAPK associates with TAB1, and p38 inhibitor SB203580 reduces both TAB1-dependent p38 phosphorylation and infarction volume. Perfused heart ischemia model (mkk3-/- mice), co-immunoprecipitation, adenoviral overexpression, SB203580 pharmacology Circulation research High 12829618
2004 Phosphorylation of TAK1 at Thr-187 is essential for its activation; intermolecular autophosphorylation of Thr-187 is required; TAB1 and TAB2 both contribute to TAK1 phosphorylation but regulate it differentially; p38alpha/TAB1/TAB2-mediated feedback control suppresses TAK1 Thr-187 phosphorylation. Phospho-specific immunoblotting, alanine-substitution mutagenesis, RNAi, kinase assay The Journal of biological chemistry High 15590691
2004 TAB1 expression in anergic CD4+ T cells activates p38alpha (MKK-independent) to suppress IL-2 production and promote IL-10 production, maintaining T cell anergy; inhibition of p38 or p38 dominant-negative rescued IL-2 and ERK activity in TAB1-expressing T hybridoma cells. Retroviral transduction, p38 inhibitor (SB203580), dominant-negative p38, cytokine ELISA, kinase assay Molecular and cellular biology Medium 15282297
2005 Crystal structure of a TAK1 chimeric protein revealed a novel binding pocket on the TAK1 kinase domain whose shape complements a unique alpha-helix in the TAK1-binding domain of TAB1, providing structural basis for the intimate hydrophobic interaction mediating TAK1 activation by TAB1. X-ray crystallography Journal of molecular biology High 16289117
2005 AMPK promotes p38 MAPK activation in the ischemic heart by increasing recruitment of p38 to TAB1; TAB1 is physically associated with the alpha2 catalytic subunit of AMPK; p38 recruitment to TAB1/AMPK complexes requires AMPK activation and is reduced in AMPK-deficient hearts. AICAR treatment, transgenic kinase-dead AMPK mice, co-immunoprecipitation, ischemia model, glucose transport assay Circulation research High 16179588
2005 TAB1 binds p38 and sequesters it in the cytoplasm, preventing p38 nuclear localization; TAB1 disrupts p38 interaction with MKK3 and redirects p38 to the cytosol; consequently, TAB1 expression antagonizes MKK3-induced downstream p38 activity and attenuates IL-1beta-induced inflammatory gene induction in cardiomyocytes. Overexpression, subcellular fractionation, co-immunoprecipitation, inflammatory gene reporter assay, confocal imaging The Journal of biological chemistry Medium 16407200
2005 TAK1 is dispensable (in vivo, in TAK1-null MEFs) for NF-kappaB and AP-1 activation by TNFR1, IL-1R, TLR3, and TLR4, whereas TAB1- and TAB2-null MEFs show normal activation through those pathways; TAK1 mediates IKK activation downstream of RIP1-TRAF2 (TNF) and MyD88-IRAK1-TRAF6 (IL-1). Conditional gene knockout in mice and MEFs, NF-kappaB/AP-1 reporter assay, epistasis analysis Genes & development High 16260493
2006 DUSP14 (MKP6) directly interacts with TAB1 and dephosphorylates TAB1 at Ser438, leading to TAB1-TAK1 complex inactivation; DUSP14-deficient T cells show enhanced phosphorylation of the TAB1-TAK1 complex and downstream JNK and IKK, and the enhanced activation was attenuated by TAB1 shRNA knockdown. Co-immunoprecipitation, phosphatase assay, DUSP14-deficient mice, TAB1 shRNA knockdown Journal of immunology High 24403530
2006 cGMP-dependent protein kinase I (PKG I) inhibits TAB1-p38 MAPK signaling: cGMP-activated PKG I interacts with p38 MAPK (requiring the N-terminal leucine-isoleucine zipper of PKG I) and prevents TAB1 binding to p38, thereby inhibiting p38 autophosphorylation and cardiac myocyte apoptosis during ischemia/reperfusion. Co-immunoprecipitation in HEK293 cells, cardiac myocyte-restricted PKG I knockout mice, simulated I/R, point mutant analysis The Journal of biological chemistry High 16943189
2006 Pro412 in the C-terminus of TAB1 is essential for its interaction with p38alpha; a cryptic D-domain-like docking site adjacent to Pro412 engages the hydrophobic docking groove of p38alpha; p38alpha residues Thr218 and Ile275 (not found in p38beta) are required for specific TAB1 binding and TAB1-induced autophosphorylation. Deletion and point mutagenesis, co-immunoprecipitation, chimeric p38alpha/p38beta analysis, kinase assay Molecular and cellular biology High 16648477
2006 TGF-beta3/TbetaR1 complex associates with adaptor TAB1 to activate both p38 MAPK and ERK signaling pathways, disrupting both the blood-testis barrier and Sertoli-germ cell adhesion; when TbetaRI preferentially associates with CD2AP instead of TAB1, only Sertoli-germ cell adhesion is perturbed, demonstrating differential signal routing by adaptor association. Co-immunoprecipitation, in vitro Sertoli cell TJ assay, in vivo TGF-beta3 administration, dominant-negative constructs The Journal of biological chemistry Medium 16617054
2007 The BIR1 domain of XIAP directly interacts with TAB1 to induce NF-kappaB activation via TAK1; crystal structures of BIR1, TAB1, and the BIR1/TAB1 complex revealed a butterfly-shaped BIR1 dimer; structure-based mutagenesis and TAB1 knockdown confirmed BIR1/TAB1 interaction is crucial for XIAP-induced TAK1 and NF-kappaB activation; Smac (caspase-inhibition antagonist) also inhibits the XIAP/TAB1 interaction. X-ray crystallography, surface plasmon resonance, structure-based mutagenesis, TAB1 knockdown, NF-kappaB reporter assay Molecular cell High 17560374
2008 TAB1 is required for TAK1 catalytic activity: TAK1 activity is undetectable in Tab1-/- MEFs after IL-1 or TNF stimulation. TAB1 is also required for p38alpha-mediated phosphorylation of TAB3 (at Ser60 and Thr404) within the TAK1 complex, acting as a scaffold that recruits p38alpha to TAK1. Tab1-/- MEF kinase assay, mass spectrometry phosphosite mapping, genetic epistasis with p38alpha/beta MAPK inhibitors The Biochemical journal High 18021073
2008 TAB1 interacts with IKKbeta to form TAB1:IKKbeta complexes in breast cancer cells undergoing EMT, leading to stimulation of a TAK1:IKKbeta:p65 pathway and NF-kappaB activation; a truncated TAB1(411) mutant reduced TGF-beta-mediated NF-kappaB activation and tumor growth. Co-immunoprecipitation, truncation mutant expression, NF-kappaB reporter, tumor xenograft Cancer research Medium 18316610
2008 TAB1 mediates osmotic stress-induced TAK1 activation (but is dispensable for TNF- or IL-1-induced TAK1 activation in MEFs); the C-terminal 68 amino acids of TAB1 are sufficient for osmotic stress-induced TAK1 activation; cell shrinkage increases TAB1-TAK1 concentration, promoting oligomerization-dependent TAK1 activation. Tab1-/- MEFs, osmotic stress assay, TAB1 truncation mutants, kinase assay The Journal of biological chemistry High 18829460
2008 TAB4 (TIP) binds TAK1 directly, enhances TAK1 autophosphorylation, and stimulates phosphorylation of two sites in TAB1 as identified by mass spectrometry; TAB4 selectively promotes IKK phosphorylation and NF-kappaB signaling. Co-immunoprecipitation, mass spectrometry phosphosite identification, in vitro kinase assay, NF-kappaB reporter The Journal of biological chemistry Medium 18456659
2009 TAK1-TAB1-TAB2 complex phosphorylates RCAN1 at Ser94 and Ser136, converting RCAN1 from an inhibitor to a facilitator of calcineurin-NFAT signaling; calcineurin in turn dephosphorylates and inhibits TAK1 and TAB1, forming a bidirectional regulatory loop; TAB2 bridges the TAK1-TAB1 and calcineurin-NFAT modules. In vitro kinase assay, co-immunoprecipitation, NFAT transcriptional reporter, cardiomyocyte hypertrophy assay, Rcan1/2- and Tab2-deficient MEFs Nature cell biology High 19136967
2009 TGF-beta1-induced TAK1 activation in mesangial cells requires TAB1-mediated autophosphorylation and does not require TbetaRI kinase activity; TAB1 does not interact with TGF-beta receptors but is indispensable for TGF-beta1-induced TAK1 activation. Kinase-dead TbetaRI mutant, co-immunoprecipitation, kinase assay, deletion mutant analysis The Journal of biological chemistry Medium 19556242
2012 TAB1 is O-GlcNAcylated on a single site, Ser395 (human), induced by IL-1 and osmotic stress; O-GlcNAcylation of TAB1 is required for full TAK1 activation upon IL-1/osmotic stress stimulation, and for downstream NF-kappaB activation and IL-6/TNFalpha production; the S395A O-GlcNAc-deficient TAB1 mutant fails to fully rescue signaling in Tab1-/- MEFs. O-GlcNAc-specific antibody, site-directed mutagenesis (S395A), Tab1-/- MEF reconstitution, kinase assay, ELISA The EMBO journal High 22307082
2013 p38alpha autophosphorylation initiated by TAB1 occurs in cis by direct interaction with TAB1 residues 371-416; crystal structures of the p38alpha-TAB1 complex revealed a bipartite docking site on the p38alpha C-terminal lobe; TAB1 binding stabilizes active p38alpha and induces helical extension of the Thr-Gly-Tyr motif in the activation segment allowing autophosphorylation in cis; a cell-permeable TAT-TAB1(371-416) peptide rapidly activates p38 and perturbs cardiac function. X-ray crystallography, chemical-genetic approaches, coexpression in mammalian/bacterial/cell-free systems, FRET, isolated cardiac myocytes and perfused mouse hearts Nature structural & molecular biology High 24037507
2013 USP18 deubiquitinates the TAK1-TAB1 complex, thereby restricting TAK1 activity; USP18-deficient T cells exhibit hyperactivation of NF-kappaB and NFAT and elevated IL-2, and USP18 physically associates with the TAK1-TAB1 complex. Co-immunoprecipitation, USP18-deficient mouse T cells, NF-kappaB/NFAT reporter assay, ubiquitination assay The Journal of experimental medicine Medium 23825189
2013 TAB1 associates with MDM2 and inhibits its E3 ligase activity toward p53 and MDMX; p38alpha activated by TAB1 phosphorylates p53 N-terminal sites leading to selective induction of NOXA; TAB1-dependent MDMX stabilization is required for cell death after cisplatin treatment; TAB1 depletion inhibits MDM2 siRNA-mediated p53 accumulation. Co-immunoprecipitation, E3 ligase assay, siRNA knockdown, p53 target gene analysis, cell viability assay Genes & development Medium 23934659
2014 TAB1 is identified as the direct binding target of triptolide (TP) in macrophages; TP inhibits TAK1 kinase activity by interfering with TAK1-TAB1 complex formation; the amino acid sequence between positions 373 and 502 of TAB1 is required for TP interaction. Pull-down assay, in vitro kinase assay, deletion mutagenesis, MAPK pathway inhibition assay Chemistry & biology Medium 24462677
2014 EV71 3C protease cleaves TAB1 at Q414-G415 and Q451-S452 (as well as TAK1 and TAB2/TAB3), disrupting the TAK1/TAB complex and inhibiting NF-kappaB activation; 3C active-site mutants (H40D or C147S) abolish cleavage activity. In vitro cleavage assay, active-site mutagenesis, NF-kappaB luciferase reporter, overexpression in mammalian cells Journal of virology Medium 24942571
2014 In senescent human T cells, AMPK triggers recruitment of p38 to the scaffold protein TAB1, causing autophosphorylation of p38 via an intrasensory (non-canonical) pathway; this AMPK-TAB1-p38 pathway inhibits telomerase activity, T cell proliferation, and TCR signalosome components; blockade of AMPK-TAB1-dependent p38 activation reverses the proliferative defect. Co-immunoprecipitation, AMPK inhibition, p38 inhibition, T cell functional assays (telomerase, proliferation) Nature immunology High 25151490
2014 MEKK1 PHD motif mediates Lys63-linked polyubiquitination of TAB1 (using conjugating enzyme UBE2N), regulating TAK1 and MAPK activation by TGF-beta and EGF; protein microarray identified TAB1 as a PHD substrate; Map3k1(mPHD) ES cells exhibit defective non-canonical ubiquitination of TAB1. Protein microarray substrate identification, in vitro ubiquitination assay, Map3k1 PHD knock-in mouse ES cells, MAPK activation assay The EMBO journal Medium 25260751
2015 E3 ubiquitin ligase Itch binds TAB1 through a conserved PPXY motif and ubiquitylates it, inhibiting p38alpha activation; knockdown of TAB1 attenuated prolonged p38alpha phosphorylation in Itch-/- cells; reconstitution with wild-type but not ligase-dead Itch-C830A inhibited p38alpha phosphorylation; a cell-permeable peptide blocking TAB1-p38alpha interaction attenuated skin inflammation. Co-immunoprecipitation, ubiquitination assay, shRNA knockdown, Itch-/- mouse model, reconstitution assay Science signaling High 25714464
2017 E3 ubiquitin ligase RNF114 mediates ubiquitination and proteasomal degradation of TAB1 during maternal-to-zygotic transition; TAB1 degradation activates the NF-kappaB pathway and is required for MZT; five substrates of RNF114 were identified by protein microarray and validated by in vitro ubiquitination. Protein microarray, in vitro ubiquitination assay, Rnf114 knockdown in mouse oocytes, NF-kappaB activity assay EMBO reports Medium 28073917
2018 Crystal structure of active pp38alpha-TAB1(1-438) complex defined 4 residues on TAB1 required for docking onto p38alpha; global TAB1 knock-in (KI) mice with these substitutions are viable; KI mice show significantly reduced infarction volume after in vivo ischemia and disabled TAB1 transphosphorylation, with only mild attenuation of myocardial p38alpha activation. X-ray crystallography, global knock-in mouse model, in vivo regional ischemia, infarction measurement, fragment screening JCI insight High 30135318
2018 p38alpha autoactivation by TAB1 is critically dependent on Thr185 of p38alpha: replacing Thr185 with Gly (T185G) prevents an intramolecular hydrogen bond with Asp150, disrupting TAB1-induced conformational change in the activation segment without affecting TAB1 binding, upstream MAP2K activation, or downstream substrate phosphorylation; T185G p38alpha-expressing cardiac cells are resistant to ischemia injury. Crystal structure-guided mutagenesis, in vitro kinase assay, cardiac myocyte ischemia model, in vivo mouse assay Molecular and cellular biology High 29229647
2018 Alpha-synuclein disrupts the anti-inflammatory effect of dopamine D2 receptor (Drd2) in astrocytes by inhibiting the association of beta-arrestin2 with TAB1, thereby promoting TAK1-TAB1 interaction and downstream neuroinflammation. Co-immunoprecipitation, Western blotting, beta-arrestin2 overexpression, primary astrocyte assay, A53T transgenic mice Journal of neuroinflammation Medium 30200997
2019 Multiple GPCR agonists (thrombin, histamine, prostaglandin E2, ADP) activate p38 MAPK via a non-canonical TAB1-TAB2 and/or TAB1-TAB3-dependent autophosphorylation pathway in endothelial cells, with MKK3/6 activation virtually undetectable; cell-type-specific dependence on TAB1-TAB2 versus TAB1-TAB3 was demonstrated by siRNA knockdown. siRNA knockdown (TAB1, TAB2, TAB3), p38 autophosphorylation assay, MKK3/6 phosphorylation assay, IL-6 ELISA, multiple endothelial cell types The Journal of biological chemistry Medium 30760523
2021 SARS-CoV-2 NSP5 (3CLpro) directly cleaves TAB1 in vitro; cleavage is specific and selective, providing a potential mechanism for enhanced cytokine production in COVID-19. In vitro cleavage assay with recombinant proteases Emerging microbes & infections Medium 33372854
2021 TRIM26 catalyzes K11-linked polyubiquitination of TAB1 at Lys294, Lys319, and Lys335, enhancing TAK1 activation and downstream NF-kappaB and MAPK signaling; Trim26-knockout mice show reduced TAK1 activation and proinflammatory cytokine induction after LPS/TNF/IL-1beta stimulation and are protected from LPS-induced septic shock. In vitro ubiquitination assay, site-directed mutagenesis, Trim26-KO and Trim26-transgenic mice, kinase assay, septic shock model, DSS colitis model Cell death and differentiation High 34017102
2022 GFAT1 interacts with TAB1 in a TAB1-Ser438 phosphorylation-dependent manner upon glucose deprivation; GFAT1 binding facilitates TTLL5-GFAT1-TAB1 complex formation; GFAT1 metabolic activity provides glutamate for TTLL5-mediated TAB1 glutamylation; glutamylated TAB1 recruits p38alpha MAPK to drive p38 activation and promote autophagy for tumor cell survival. Co-immunoprecipitation, mass spectrometry, site-directed mutagenesis (S438A), TTLL5 glutamylation assay, p38 activation assay, autophagy assay Cell discovery Medium 35945223
2023 RNF207 promotes K63-linked ubiquitination of TAB1, triggering TAK1 autophosphorylation and activation of downstream p38 and JNK1/2, exacerbating pathological cardiac hypertrophy; TAB1 knockdown attenuated RNF207-overexpression-induced cardiomyocyte hypertrophy. Co-immunoprecipitation, in vitro ubiquitination assay, TAC mouse model, TAB1 knockdown in cardiomyocytes Cardiovascular research Medium 35352799

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes & development 622 16260493
1996 TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science (New York, N.Y.) 533 8638164
2002 MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science (New York, N.Y.) 457 11847341
1999 XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. The EMBO journal 314 9878061
2014 The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells. Nature immunology 267 25151490
2003 Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Nature cell biology 243 12598905
2007 XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Molecular cell 233 17560374
2021 SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species. Emerging microbes & infections 214 33372854
2005 AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. Circulation research 193 16179588
1998 Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. The EMBO journal 190 9463380
2004 Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. The Journal of biological chemistry 186 15590691
2000 Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1. FEBS letters 156 10838074
2012 O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release. The EMBO journal 138 22307082
2003 Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia. Circulation research 116 12829618
2013 USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. The Journal of experimental medicine 113 23825189
2009 Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nature cell biology 113 19136967
2013 Mechanism and consequence of the autoactivation of p38α mitogen-activated protein kinase promoted by TAB1. Nature structural & molecular biology 91 24037507
2006 Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. The Journal of biological chemistry 87 16617054
2014 Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex. Journal of virology 86 24942571
2002 Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mechanisms of development 86 12464436
2006 cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes. The Journal of biological chemistry 79 16943189
2005 Structural basis for the interaction of TAK1 kinase with its activating protein TAB1. Journal of molecular biology 79 16289117
2008 Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression. Cancer research 77 18316610
2002 TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways. Biochemical and biophysical research communications 73 12372426
2005 TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. The Journal of biological chemistry 69 16407200
2009 Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells. The Journal of biological chemistry 68 19556242
2021 TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1. Cell death and differentiation 63 34017102
2002 TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. The Journal of biological chemistry 61 12429732
2008 Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. The Biochemical journal 60 18021073
2014 Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. Journal of immunology (Baltimore, Md. : 1950) 59 24403530
2014 TAB1: a target of triptolide in macrophages. Chemistry & biology 59 24462677
2008 TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling. The Journal of biological chemistry 59 18829460
2001 An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK. The Journal of biological chemistry 56 11323434
2017 The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition. EMBO reports 55 28073917
2018 α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes. Journal of neuroinflammation 50 30200997
2018 Oxidative stress-induced TGF-beta/TAB1-mediated p38MAPK activation in human amnion epithelial cells. Biology of reproduction 47 29893818
2015 The E3 ubiquitin ligase Itch inhibits p38α signaling and skin inflammation through the ubiquitylation of Tab1. Science signaling 46 25714464
2008 TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB. The Journal of biological chemistry 43 18456659
2019 G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells. The Journal of biological chemistry 42 30760523
2014 The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. The EMBO journal 41 25260751
2004 Regulation of the maintenance of peripheral T-cell anergy by TAB1-mediated p38 alpha activation. Molecular and cellular biology 41 15282297
2013 Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry. Genes & development 38 23934659
2020 Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1β-IL1R and p38α-TAB1 Complexes. Journal of medicinal chemistry 37 32543856
2020 TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 37 33044562
2017 NF-κB1, c-Rel, and ELK1 inhibit miR-134 expression leading to TAB1 upregulation in paclitaxel-resistant human ovarian cancer. Oncotarget 37 28206956
2022 GFAT1-linked TAB1 glutamylation sustains p38 MAPK activation and promotes lung cancer cell survival under glucose starvation. Cell discovery 35 35945223
2023 RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Cardiovascular research 34 35352799
2018 Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway. Cancer biology & therapy 28 30462562
2018 miR‑873 inhibits colorectal cancer cell proliferation by targeting TRAF5 and TAB1. Oncology reports 26 29328486
2006 Determinants that control the specific interactions between TAB1 and p38alpha. Molecular and cellular biology 25 16648477
2011 Procarcinogenic effects of cyclosporine A are mediated through the activation of TAK1/TAB1 signaling pathway. Biochemical and biophysical research communications 24 21333626
2023 Hsa_circ_0021727 (circ-CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFκB pathway. Cell death & disease 21 36609391
2018 The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules. JCI insight 21 30135318
2018 TAB1-Induced Autoactivation of p38α Mitogen-Activated Protein Kinase Is Crucially Dependent on Threonine 185. Molecular and cellular biology 20 29229647
2018 The interaction of TAK1 and TAB1 enhances LPS-induced cytokine release via modulating NF-κB activation (Larimichthys crocea). Fish & shellfish immunology 20 29325713
2015 Docosahexaenoic acid inhibits inflammation via free fatty acid receptor FFA4, disruption of TAB2 interaction with TAK1/TAB1 and downregulation of ERK-dependent Egr-1 expression in EA.hy926 cells. Molecular nutrition & food research 20 26577385
2013 Disruption of TAB1/p38α interaction using a cell-permeable peptide limits myocardial ischemia/reperfusion injury. Molecular therapy : the journal of the American Society of Gene Therapy 20 23877036
2010 Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic Injury Via Inhibition of TAB1-p38 Apoptosis Signaling. Frontiers in pharmacology 19 21607062
2019 MiR-758-3p regulates papillary thyroid cancer cell proliferation and migration by targeting TAB1. Die Pharmazie 18 30940308
2017 Shrimp TAB1 interacts with TAK1 and p38 and activates the host innate immune response to bacterial infection. Molecular immunology 18 28577391
2022 Inducible MicroRNA-132 Inhibits the Production of Inflammatory Cytokines by Targeting TRAF6, TAK1, and TAB1 in Teleost Fish. Infection and immunity 17 35416706
2022 miR-146a-5p promotes epithelium regeneration against LPS-induced inflammatory injury via targeting TAB1/TAK1/NF-κB signaling pathway. International journal of biological macromolecules 17 36096257
2022 Palmatine alleviates LPS-induced acute lung injury via interfering the interaction of TAK1 and TAB1. Biochemical pharmacology 16 35760111
2011 A small peptide modeled after the NRAGE repeat domain inhibits XIAP-TAB1-TAK1 signaling for NF-κB activation and apoptosis in P19 cells. PloS one 16 21789165
2006 TAB1 modulates IL-1alpha mediated cytokine secretion but is dispensable for TAK1 activation. Cellular signalling 16 17052891
2023 Plant miRNA osa-miR172d-5p suppressed lung fibrosis by targeting Tab1. Scientific reports 15 36746980
2022 The MIR100HG/miR-29a-3p/Tab1 axis modulates TGF-β1-induced fibrotic changes in type II alveolar epithelial cells BLM-caused lung fibrogenesis in mice. Toxicology letters 15 35472619
2021 MicroRNA-211 regulates the expression of TAB1 and inhibits the NF-κB signaling pathway in lipopolysaccharide-induced endometritis. International immunopharmacology 15 33984721
2020 Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells. Journal of Cancer 15 31892970
2013 Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-κB activation. Molecular and cellular biology 15 23297344
2008 Generation of a conditional mutant allele for Tab1 in mouse. Genesis (New York, N.Y. : 2000) 15 18693278
2013 Regulation of TAK1/TAB1-mediated IL-1β signaling by cytoplasmic PPARβ/δ. PloS one 14 23646170
2022 Exosomal miR-767 from senescent endothelial-derived accelerating skin fibroblasts aging via inhibiting TAB1. Journal of molecular histology 13 36409439
2014 TAK1-binding proteins (TAB1 and TAB2) in grass carp (Ctenopharyngodon idella): identification, characterization, and expression analysis after infection with Ichthyophthirius multifiliis. Fish & shellfish immunology 12 24747054
2011 Rhesus monkey TRIM5α represses HIV-1 LTR promoter activity by negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated NF-κB activation. Archives of virology 12 21918865
2019 ΜicroRNA‑889 plays a suppressive role in cell proliferation and invasion by directly targeting TAB1 in non‑small cell lung cancer. Molecular medicine reports 11 31115539
2019 Black carp TAB1 up-regulates TAK1/IRF7/IFN signaling during the antiviral innate immune activation. Fish & shellfish immunology 10 31002927
2009 Suppression of cell invasiveness by periostin via TAB1/TAK1. International journal of oncology 10 19578758
2022 Tongguanteng injection reverses paclitaxel resistance via upregulation of TAB1 expression in ovarian cancer in vitro and in vivo. Journal of ethnopharmacology 9 36126783
2019 Molecular characterization and expression of TAK-binding proteins (TAB1-3) in Larimichthys crocea infected by Vibrio parahemolyticus and LPS. Developmental and comparative immunology 9 31051196
2015 Expression of TAK1/TAB1 expression in non-small cell lung carcinoma and adjacent normal tissues and their clinical significance. International journal of clinical and experimental pathology 9 26884850
2011 Stercurensin inhibits nuclear factor-κB-dependent inflammatory signals through attenuation of TAK1-TAB1 complex formation. Journal of cellular biochemistry 9 21268076
2006 Role of TAB1 in nitric oxide-induced p38 activation in insulin-producing cells. International journal of biological sciences 9 17205106
2010 Immunolocalization of TAK1, TAB1, and p38 in the developing rat molar. Anatomical science international 8 20730577
2013 Crystal structure of the p38α MAP kinase in complex with a docking peptide from TAB1. Science China. Life sciences 7 23722236
2025 Explore on the Mechanism of miRNA-146a/TAB1 in the Regulation of Cellular Apoptosis and Inflammation in Ulcerative Colitis Based on NF-κB Pathway. Current molecular medicine 6 38347777
2020 Myeloma cells self-promote migration by regulating TAB1-driven TIMP-1 expression in mesenchymal stem cells. Biochemical and biophysical research communications 6 33183761
2016 Model Predicts That MKP1 and TAB1 Regulate p38α Nuclear Pulse and Its Basal Activity through Positive and Negative Feedback Loops in Response to IL-1. PloS one 6 27314954
2015 Identification and characterization of a TAB1 gene involved in innate immunity of amphioxus (Branchiostoma belcheri). Gene 6 26341057
2021 TAK1 of blunt snout bream promotes NF-κB activation via interaction with TAB1 in response to pathogenic bacteria. Fish & shellfish immunology 5 34923116
2020 A mouse model for functional dissection of TAB1 O-GlcNAcylation. Wellcome open research 5 32676538
2022 TAB1 binding induced p38α conformation change: an accelerated molecular dynamics simulation study. Physical chemistry chemical physics : PCCP 4 35441632
2022 Allosteric Boost by TAB1 on the TAK1 Kinase Favorably Sculpts the Thermodynamic Landscape of Activation. Journal of chemical information and modeling 4 36374995
2018 Molecular identification and expression analysis of TAB1 from orange-spotted grouper (Epinephelus coioides). Developmental and comparative immunology 4 30248360
2025 Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1. Acta pharmaceutica Sinica. B 3 40698135
2025 TNIP3 Attenuates Colitis by Inhibiting the TAB1/NF-κB/NLRP3 Signaling Pathway in Macrophages. Digestive diseases and sciences 2 41436895
2024 Molecular characterization, expression and functional analysis of TAK1, TAB1 and TAB2 in Nile tilapia (Oreochromis niloticus). Fish & shellfish immunology 2 38184182
2022 Chlamydia trachomatis antigen induces TLR4-TAB1-mediated inflammation, but not cell death, in maternal decidua cells. American journal of reproductive immunology (New York, N.Y. : 1989) 2 36495029
2023 Down-regulated TAB1 suppresses the replication of Coxsackievirus B5 via activating the NF-κB pathways through interaction with viral 3D polymerase. Virology journal 1 38072991
2024 The inhibitory effect of swine TAB1 on the replication of pseudorabies virus. Veterinary microbiology 0 38971118

Missed literature

Know a paper Affinage missed for TAB1? Flag it for the maintainers and the community.

No submissions yet.