Affinage

SURF4

Surfeit locus protein 4 · UniProt O15260

Length
269 aa
Mass
30.4 kDa
Annotated
2026-06-10
35 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SURF4 is an ER-resident polytopic transmembrane cargo receptor that selectively captures soluble secretory proteins and delivers them into the COPII-dependent ER-to-Golgi pathway (PMID:7540914, PMID:30251625, PMID:30086131). It recognizes cargo through N-terminal tripeptide ER-ESCAPE motifs exposed after signal-sequence cleavage, with binding affinity scaling to cargo aggregation propensity and single residue changes altering ER retention (PMID:30086131); ER export signals can engage a lumenal SURF4 pocket co-translationally rather than requiring prior cargo folding (PMID:39531033). SURF4 co-clusters with bound cargo to expand ER exit sites and nucleates a distinct tubular ERGIC (ERGIC-53-negative, Rab1A/B-positive) that accelerates ER-to-Golgi transport, a process antagonized by KDEL-mediated retrieval (PMID:35051356). Cargo is loaded into COPII vesicles via paralog-selective SEC24 engagement and accessory factors, including a TMED10 co-receptor route for PCSK9 (PMID:39531033, PMID:35562580). Through this machinery SURF4 mediates secretion of a broad cargo repertoire — PCSK9, apolipoprotein B and VLDL/chylomicron lipoproteins, erythropoietin, proinsulin, the progranulin/prosaposin pair, Sonic Hedgehog, and SAA1 — with cargo recognition governed by complex determinants beyond a single universal motif (PMID:30251625, PMID:29643117, PMID:32989016, PMID:34919127, PMID:34118252, PMID:35271396, PMID:35562580, PMID:37844105, PMID:38042368, PMID:39105051). SURF4 also functions in the ERGIC/Golgi architecture maintenance via interactions with ERGIC-53 and p24 proteins and COPI recruitment (PMID:18287528), cooperates with derlin-2/derlin-1 to retrotranslocate COX-2 during ERAD (PMID:37676109), and negatively modulates STIM1-dependent store-operated Ca²⁺ entry (PMID:22609200). SURF4-mediated export is negatively regulated by direct binding of YIPF5 [PMID:bio_10.1101_2025.06.11.659036]. Loss of Surf4 is embryonic lethal in mice, and tissue-specific deletion lowers plasma cholesterol, triglycerides and PCSK9 and attenuates atherosclerosis and liver fibrosis (PMID:31978056, PMID:34118252, PMID:36193893, PMID:39105051).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1995 Medium

    Established the basic identity of SURF4 as an ER membrane protein, defining where in the cell it could act before any function was known.

    Evidence In vitro translation, microsomal fractionation, proteolysis protection, and immunofluorescence of myc-tagged chimeras

    PMID:7540914

    Open questions at the time
    • No cargo or pathway function assigned
    • Transmembrane topology only predicted, not resolved
  2. 2008 High

    Showed SURF4 is not merely ER-resident but a structural participant in early secretory architecture, physically engaging ERGIC-53 and p24 proteins to maintain ERGIC clusters and Golgi integrity.

    Evidence Co-IP, siRNA co-silencing, live imaging, and brefeldin A assays in cultured cells

    PMID:18287528

    Open questions at the time
    • Did not identify soluble cargoes
    • Mechanism of COPI recruitment not defined
  3. 2012 Medium

    Revealed a non-trafficking role by linking SURF4 to ER calcium signaling, showing it restrains STIM1-mediated store-operated Ca²⁺ entry.

    Evidence Affinity purification, co-IP, and Ca²⁺ entry measurements in Surf4-knockout DT40 B cells

    PMID:22609200

    Open questions at the time
    • Molecular basis of STIM1 modulation unresolved
    • Single cell-type system
  4. 2018 High

    Defined SURF4 as a selective cargo receptor and decoded its recognition logic — N-terminal ER-ESCAPE tripeptide motifs exposed after signal cleavage — establishing how it discriminates soluble export clients.

    Evidence Systematic mutagenesis of ~8,000 tripeptide variants, KO human cells, and rescue with SURF4 or yeast Erv29p; parallel BioID/CRISPR/co-IP studies identifying PCSK9 and apoB/VIT-2 as cargoes

    PMID:29643117 PMID:30086131 PMID:30251625

    Open questions at the time
    • Structural basis of motif binding pocket not resolved
    • Did not explain cargoes lacking strong motifs
  5. 2020 High

    Extended the cargo repertoire to erythropoietin and demonstrated organismal essentiality, showing SURF4 function is required for early embryonic development.

    Evidence Genome-scale CRISPR screen, multiple sgRNAs, rescue, co-IP for EPO; CRISPR/Cas9 germline knockout mice

    PMID:31978056 PMID:32989016

    Open questions at the time
    • Essential embryonic cargo not identified
    • EPO recognition determinants undefined
  6. 2021 Medium

    Broadened cargo classes (progranulin via a prosaposin relay) and connected SURF4 to ER stress signaling during cell reprogramming, indicating roles beyond constitutive secretion.

    Evidence Co-IP, KD/KO secretion assays for progranulin/prosaposin; reprogramming system with RNA-seq and UPR inhibition

    PMID:34585448 PMID:34919127

    Open questions at the time
    • Reprogramming role is indirect pathway placement
    • How SURF4 activates UPR unclear
  7. 2022 High

    Resolved the trafficking machinery in mechanistic and physiological depth — SURF4 nucleates a fast tubular ERGIC, cooperates with Sec12 for proinsulin export, relays Shh to proteoglycans, and drives hepatic lipoprotein secretion in vivo.

    Evidence Superresolution live imaging with KO/rescue/mutagenesis; co-IP with proinsulin and Sec12; proteoglycan competition; conditional liver KO and acute depletion mice with lipid/PCSK9 readouts

    PMID:35051356 PMID:35271396 PMID:35562580 PMID:36193893

    Open questions at the time
    • Hepatic PCSK9 dependence differed between models
    • Structural mechanism of t-ERGIC biogenesis unresolved
  8. 2023 Medium

    Generalized SURF4's cargo scope by unbiased proteomics, revealed an ERAD retrotranslocation role with derlins, and extended physiological function to intestinal lipoprotein secretion.

    Evidence Mass spectrometry of KO conditioned media/lysates; CRISPR/co-IP/ubiquitylation epistasis with derlin-1/2, p97 and COX-2; intestine-specific KO mice with co-IP

    PMID:37676109 PMID:37844105 PMID:38042368

    Open questions at the time
    • Cargo recognition rules not unified into a single code
    • ERAD role mechanistically distinct from anterograde function and based on single lab
  9. 2024 High

    Dissected COPII coupling at paralog resolution and added disease-relevant cargo, showing SURF4 selects specific SEC24 paralogs (plus a TMED10 co-receptor for PCSK9) and routes SAA1 to drive fibrogenic signaling.

    Evidence SEC24 paralog mutant epistasis, lumenal pocket mutagenesis, co-translational binding assays; conditional liver KO with SAA1-TLR2 epistasis in fibrosis model

    PMID:39105051 PMID:39531033

    Open questions at the time
    • Structure of cargo-loaded SURF4–SEC24 complex unknown
    • Determinants of paralog choice not fully defined
  10. 2025 Medium

    Identified an upstream negative regulator, showing YIPF5 directly binds SURF4 and restrains its export and ERGIC tubule formation.

    Evidence Co-IP (direct interaction), YIPF5 KO cells, live imaging of ERGIC tubules, kinetic secretion assays (preprint)

    PMID:bio_10.1101_2025.06.11.659036

    Open questions at the time
    • Preprint, single lab, not peer-reviewed
    • Mechanism by which YIPF5 inhibits SURF4 unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • The essential embryonic cargo(es) underlying Surf4 knockout lethality and a unified structural/biochemical code reconciling motif-based and folding-independent cargo recognition remain undefined.
  • No structure of SURF4 with bound cargo
  • No single recognition rule explains the full cargo repertoire
  • Essential developmental cargo unidentified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0038024 cargo receptor activity 5 GO:0140313 molecular sequestering activity 2
Localization
GO:0005783 endoplasmic reticulum 4
Pathway
R-HSA-392499 Metabolism of proteins 4 R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-1430728 Metabolism 3 R-HSA-9609507 Protein localization 3
Partners
DERL2ERGIC-53SEC12SEC24ASEC24CSTIM1TMED10YIPF5

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 SURF4 (Surf-4) is a ~30 kDa integral membrane protein with at least two (predicted seven) transmembrane domains, a C-terminal double-lysine ER retrieval motif, and localizes to the ER (not plasma membrane), as shown by salt/detergent microsomal fractionation and immunofluorescence of myc-tagged chimeras. In vitro translation, salt/detergent extraction, proteolysis protection assay, immunofluorescence of myc-tagged Surf4 transfectants Molecular membrane biology Medium 7540914
2008 SURF4 physically interacts with ERGIC-53 and p24 proteins in the early secretory pathway. Co-silencing SURF4 with ERGIC-53, or silencing the p24 family member p25, causes reduced ERGIC cluster number and Golgi fragmentation, partial redistribution of COPI (but not Golgi matrix proteins) to the cytosol, and partial brefeldin-A resistance of the cis-Golgi—without blocking anterograde transport. Live imaging showed decreased ERGIC cluster stability after p25 knockdown. Co-immunoprecipitation, siRNA knockdown, live-cell imaging, immunofluorescence, brefeldin A treatment Molecular biology of the cell High 18287528
2018 SURF4 is the primary ER cargo receptor mediating efficient secretion of PCSK9 in HEK293T cells. SURF4 localizes to the early secretory pathway, physically interacts with PCSK9, and its deletion causes ER accumulation and reduced extracellular secretion of PCSK9, rescued by SURF4 cDNA re-expression. Proximity-dependent biotinylation (BioID) proteomics, genome-scale CRISPR screen, multiple independent sgRNAs, clonal SURF4-deficient cell lines, functional rescue with SURF4 cDNA, co-immunoprecipitation, subcellular fractionation eLife High 30251625
2018 SURF4 functions as a cargo receptor that binds amino-terminal tripeptide motifs (ER-ESCAPE motifs) exposed after signal sequence cleavage on soluble cargo proteins, enabling their preferential ER export. Binding affinity scales with aggregation propensity of the cargo; single amino acid changes in the tripeptide alter ER retention. Human cells lacking SURF4 lose preferential trafficking of strong ER-ESCAPE motif cargoes; re-expression of SURF4 or yeast Erv29p rescues this. Mutagenesis of N-terminal tripeptide motifs, SURF4 knockout human cells, functional rescue with SURF4 or Erv29p, systematic survey of 8,000 tripeptide variants, secretion assays PLoS biology High 30086131
2018 SFT-4 (C. elegans SURF4 homolog) localizes predominantly to ER exit sites (ERES) and physically interacts with the yolk lipoprotein VIT-2, promoting its ER export. Mammalian SURF4 physically interacts with apolipoprotein B and its loss causes ER accumulation of apoB in human hepatic HepG2 cells. Loss of SFT-4/SURF4 also reduces the number of COPII-positive ERES. Co-immunoprecipitation, immunofluorescence colocalization, in vivo interaction assay in C. elegans, siRNA knockdown in HepG2 cells, ERES quantification The Journal of cell biology High 29643117
2012 SURF4 associates with STIM1 in the ER. Deletion of Surf4 in DT40 B cells results in markedly increased store-operated Ca²⁺ entry (SOCE) and facilitated STIM1 clustering upon store depletion, indicating SURF4 negatively modulates STIM1-mediated SOCE. Affinity purification for STIM1-binding proteins, co-immunoprecipitation, Surf4 knockout DT40 B cells, Ca²⁺ entry measurements Biochemical and biophysical research communications Medium 22609200
2020 SURF4 functions as an ER cargo receptor mediating efficient secretion of erythropoietin (EPO). SURF4 disruption causes intracellular EPO accumulation in the ER and reduced extracellular EPO; SURF4 and EPO physically interact. SURF4 overexpression increases EPO secretion. These findings were confirmed in multiple cell lines including endogenous EPO-secreting Hep3B cells under hypoxia. Genome-scale CRISPR screen, multiple independent sgRNAs, SURF4 cDNA rescue, co-immunoprecipitation, subcellular fractionation/immunofluorescence, endogenous EPO secretion assay Molecular and cellular biology High 32989016
2020 Homozygous Surf4 knockout mice are embryonic lethal (between E3.5 and E9.5), demonstrating SURF4 is essential for early embryonic development in vivo, and implying additional essential cargoes or functions beyond known ones. CRISPR/Cas9 germline knockout mice, embryonic staging PloS one Medium 31978056
2021 Progranulin interacts with prosaposin in the ER lumen; prosaposin physically interacts with SURF4, and SURF4 is critical for efficient ER exit of both progranulin and prosaposin. Thus SURF4 mediates lysosomal delivery of progranulin via a prosaposin relay. Co-immunoprecipitation, SURF4 knockdown/knockout, subcellular fractionation, secretion assays The Journal of cell biology Medium 34919127
2021 Hepatic liver-specific Surf4 knockout mice show no effect on PCSK9 secretion (negative finding for this model), but a significant reduction in plasma cholesterol, triglycerides, and apoB due to impaired VLDL secretion. Surf4 co-immunoprecipitates and colocalizes with apolipoprotein B100 in human hepatocytes. Knockdown of hepatic Surf4 in Ldlr-/- mice reduces atherosclerosis without causing liver lipid accumulation. Liver-specific Surf4 knockout mice, co-immunoprecipitation, immunofluorescence colocalization, siRNA knockdown, lipid measurements, atherosclerosis quantification Journal of lipid research High 34118252
2022 SURF4 induces a distinct tubular ERGIC (t-ERGIC) that is ERGIC-53-negative but Rab1A/B-positive, with high surface-to-volume ratio and fast ER-to-Golgi travel speed. SURF4 recognizes N-terminal signals of soluble cargoes, co-clusters with them to expand the ER exit site, and t-ERGIC biogenesis and cargo selectivity both depend on SURF4. The fast SURF4-dependent transport is antagonized by KDEL-mediated ER retrieval. Live-cell superresolution imaging, SURF4 KO/knockdown, SURF4 rescue, N-terminal signal mutagenesis, trafficking kinetics assays Developmental cell High 35051356
2022 SURF4 facilitates ER export of Sonic Hedgehog (Shh) via an ER export signal, and proteoglycans promote dissociation of SURF4 from Shh at the Golgi, constituting a SURF4-to-proteoglycan relay mechanism for Shh secretion. Co-immunoprecipitation, ER export signal mutagenesis, proteoglycan competition assays, subcellular fractionation Proceedings of the National Academy of Sciences of the United States of America Medium 35271396
2022 Surf4 promotes ER export of proinsulin in pancreatic β-cells by recruiting proinsulin to ERES. Surf4 expression is upregulated under high-glucose conditions. Surf4 forms oligomers and physically interacts with both proinsulin and Sec12 (essential for COPII vesicle formation), suggesting it delivers proinsulin into COPII vesicles cooperatively with Sec12. Surf4 knockdown causes proinsulin ER retention and decreased mature insulin and insulin secretion. Surf4 knockdown, co-immunoprecipitation with proinsulin and Sec12, immunofluorescence colocalization at ERES, insulin secretion assays, oligomerization assays Communications biology High 35562580
2022 Hepatic Surf4-conditional knockout mice show ~60% reduction in plasma PCSK9, ~50% increase in hepatic LDLR, and a severe defect in hepatic lipoprotein secretion (APOB-containing lipoproteins), causing marked reduction in plasma cholesterol and triglycerides. Acute depletion by liver-targeted CRISPR/Cas9 or siRNA confirms these findings in vivo. Conditional KO mice (Surf4 Alb-Cre), acute CRISPR/Cas9 and siRNA depletion in adult mice, plasma PCSK9/LDLR/lipid measurements, lipoprotein metabolism characterization eLife High 36193893
2023 SURF4 traffics a broad range of secretory cargoes in HuH7 hepatocytes, as identified by mass spectrometry of conditioned media and cell lysates from SURF4 CRISPR knockout cells. Cargo recognition is governed by complex mechanisms rather than a universal binding motif. CRISPR gene inactivation, mass spectrometry of conditioned media and cell lysates Journal of proteome research Medium 37844105
2023 Intestinal Surf4 is essential for apolipoprotein (ApoA1, ApoB48, PRAP1) transport and chylomicron/HDL secretion. Intestine-specific Surf4 KO mice display ectopic lipid deposition in the small intestine and hypolipidemia. Surf4 co-localizes with apoB and co-immunoprecipitates with apoB48 in differentiated Caco-2 cells. Intestine-specific KO mice, co-immunoprecipitation, immunofluorescence colocalization, proteomics, lipid measurements Molecular metabolism High 38042368
2023 Surf4 collaborates with derlin-2 and derlin-1 in ERAD: Surf4 acts downstream of derlin-2 and derlin-1 to mediate COX-2 translocation from the ER lumen to the cytosol. Surf4 knockdown impedes COX-2 ubiquitylation and its interaction with caveolin-1 and p97 in the cytosol. Surf4 and p97 preferentially interact with non-glycosylated COX-2. CRISPR library screen, siRNA knockdown, co-immunoprecipitation, ubiquitylation assays, N-glycosylation mutant analysis Journal of cell science Medium 37676109
2024 SURF4 recruits different SEC24 paralogs of the COPII coat for export of different cargoes: PCSK9 requires both SURF4 and co-receptor TMED10 for export via SEC24A, whereas Cab45 and NUCB1 require SEC24C/D. ER export signals of Cab45 and NUCB1 bind co-translationally to a lumenal pocket of SURF4, contrasting models requiring cargo folding before receptor engagement. Epistasis using SEC24 paralog-specific mutants, co-immunoprecipitation with TMED10, mutagenesis of lumenal SURF4 pocket, co-translational binding assays, secretion assays The Journal of cell biology High 39531033
2024 Hepatic SURF4 facilitates SAA1 (serum amyloid A1) secretion. SURF4 co-immunoprecipitates and colocalizes with SAA1. Surf4 liver-specific KO reduces SAA1 secretion from hepatocytes, decreasing hepatic stellate cell (HSC) activation (via SAA1-TLR2 signaling) and attenuating liver fibrosis. Conditional Surf4 KO mice, co-immunoprecipitation, colocalization, conditioned medium assays, SAA1 knockdown epistasis, TLR2 knockdown in LX-2 cells, CCl4-fibrosis model Research (Washington, D.C.) High 39105051
2021 Surf4 facilitates somatic cell reprogramming to iPSCs by activating the ER stress response (UPR) at an early stage of reprogramming. Surf4 co-expressed with OSKM activates Hspa5 and spliced Xbp1; blocking UPR compromises Surf4's reprogramming effect. Secondary reprogramming system, RNA-seq, qPCR, Western blot, alkaline phosphatase staining, UPR inhibition experiments Cell proliferation Medium 34585448
2025 YIPF5 directly interacts with SURF4 and negatively regulates SURF4-mediated ER export. YIPF5 depletion alters SURF4 localization, causing elongated ERGIC53- and Rab1-positive tubules from COPII-labeled ER exit sites, and kinetic analysis shows enhanced SURF4-mediated ER export in YIPF5 KO cells. Co-immunoprecipitation (direct interaction), YIPF5 KO cells, live-cell imaging of ERGIC tubules, kinetic secretion assays bioRxivpreprint Medium bio_10.1101_2025.06.11.659036

Source papers

Stage 0 corpus · 35 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. Molecular biology of the cell 98 18287528
2018 The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9. eLife 80 30251625
2018 Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum. PLoS biology 57 30086131
2018 SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization. The Journal of cell biology 51 29643117
2022 SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport. Developmental cell 35 35051356
1995 The surf-4 gene encodes a novel 30 kDa integral membrane protein. Molecular membrane biology 34 7540914
2012 Surf4 modulates STIM1-dependent calcium entry. Biochemical and biophysical research communications 33 22609200
2022 A SURF4-to-proteoglycan relay mechanism that mediates the sorting and secretion of a tagged variant of sonic hedgehog. Proceedings of the National Academy of Sciences of the United States of America 32 35271396
2020 The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion. Molecular and cellular biology 30 32989016
2022 Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol. eLife 27 36193893
2021 Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4. Journal of lipid research 25 34118252
2022 Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells. Communications biology 24 35562580
2020 Murine Surf4 is essential for early embryonic development. PloS one 24 31978056
2023 Surf4, cargo trafficking, lipid metabolism, and therapeutic implications. Journal of molecular cell biology 23 36574593
2021 Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo. The Journal of cell biology 19 34919127
2023 Surf4 (Surfeit Locus Protein 4) Deficiency Reduces Intestinal Lipid Absorption and Secretion and Decreases Metabolism in Mice. Arteriosclerosis, thrombosis, and vascular biology 15 36756879
2020 SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells. Journal of gynecologic oncology 14 32026660
2022 The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE-/- mice. Biochimica et biophysica acta. Molecular and cell biology of lipids 12 35803528
2021 Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress. Cell proliferation 10 34585448
2018 SURF4 has oncogenic potential in NIH3T3 cells. Biochemical and biophysical research communications 10 29777698
2024 Hepatic Surf4 Deficiency Impairs Serum Amyloid A1 Secretion and Attenuates Liver Fibrosis in Mice. Research (Washington, D.C.) 9 39105051
2023 Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion. Molecular metabolism 9 38042368
2024 ER export via SURF4 uses diverse mechanisms of both client and coat engagement. The Journal of cell biology 8 39531033
2023 Identification of LMAN1- and SURF4-Dependent Secretory Cargoes. Journal of proteome research 7 37844105
2021 Loss of Hepatic Surf4 Depletes Lipid Droplets in the Adrenal Cortex but Does Not Impair Adrenal Hormone Production. Frontiers in cardiovascular medicine 7 34859075
2012 Positive diversifying selection on the Plasmodium falciparum surf4.1 gene in Thailand. Tropical medicine and health 5 23264727
1996 Tissue-specific processing of the Surf-5 and Surf-4 mRNAs. Gene expression 5 9196076
2025 Distinct but Redundant Roles of ER Cargo Receptors p24 and Erv29 in Facilitating Proper Secretion of Cellulases in Trichoderma reesei. Molecular microbiology 2 39895577
2023 Surf4 collaborates with derlin-2 and derlin-1 to mediate cyclooxygenase-2 translocation to the cytosol for degradation. Journal of cell science 2 37676109
2023 Identification of LMAN1 and SURF4 dependent secretory cargoes. bioRxiv : the preprint server for biology 1 37066360
2026 SURF4 inhibits autophagy to enhance lung adenocarcinoma progression and stemness through Hedgehog pathway regulation. Tissue & cell 0 41637921
2025 [High expression of SURF4 promotes migration, invasion and proliferation of gastric cancer cells by inhibiting tight junction proteins]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 0 40916534
2025 Intestinal SURF4 in dyslipidaemia and female-specific metabolic disorders: insights from rats with polycystic ovary syndrome. Frontiers in nutrition 0 41041130
2024 Plasmodium falciparum surf4.1 in clinical isolates: From genetic variation and variant diversity to in silico design immunopeptides for vaccine development. PloS one 0 39775228
2023 Corrigendum: Loss of hepatic Surf4 depletes lipid droplets in the adrenal cortex but does not impair adrenal hormone production. Frontiers in cardiovascular medicine 0 37234368

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