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Showing STRADA — STRAD is a alias.

STRADA

STE20-related kinase adapter protein alpha · UniProt Q7RTN6

Length
431 aa
Mass
48.4 kDa
Annotated
2026-06-10
33 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

STRADA (STRADα) is a catalytically inactive STE20-like pseudokinase that serves as the obligate adaptor for the LKB1 tumor suppressor kinase, assembling with LKB1 and the scaffold MO25 into a heterotrimeric complex that functions as the upstream AMPK kinase (AMPKK), phosphorylating AMPK at Thr172 (PMID:14511394, PMID:12805220). Within this complex STRADA binds LKB1 as a pseudosubstrate in a closed, active-kinase-like conformation, and together with MO25 — which contacts the LKB1 activation loop — allosterically drives LKB1 into its active state without requiring T-loop phosphorylation (PMID:15561763, PMID:19892943). STRADA also dictates LKB1 subcellular distribution, translocating it from the nucleus to the cytoplasm, and stabilizes LKB1 protein levels through cytoplasmic compartmentalization, a function specific to the α paralog (PMID:12805220, PMID:17482549, PMID:24594058). Through activated LKB1, STRADA governs diverse processes: it is sufficient to drive complete apicobasal polarization of single epithelial cells including apical brush-border formation (PMID:15016379), with E-cadherin-dependent adherens junctions positioning the LKB1/STRAD complex to license AMPK phosphorylation (PMID:19110428) and a downstream MO25α–Mst4–Ezrin axis executing brush-border induction (PMID:19386264); it is required for axon specification in cortical neurons (PMID:17482549, PMID:24594058); and it restrains mTORC1 signaling to control neural progenitor proliferation, migration, and cortical development (PMID:17522105, PMID:23616120). Homozygous deletion of STRADA causes PMSE syndrome (polyhydramnios, megalencephaly, symptomatic epilepsy), driven by constitutive mTORC1 activation that is pharmacologically reversible with rapamycin (PMID:17522105, PMID:23616120).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2003 High

    Established that STRADA is not a free-standing enzyme but a required subunit of the long-sought upstream AMPK kinase, defining its core biochemical role.

    Evidence Biochemical purification from rat liver, reconstitution of recombinant LKB1/STRAD/MO25, in vitro kinase assays, and LKB1-knockout MEFs

    PMID:12805220 PMID:14511394

    Open questions at the time
    • Did not resolve how a catalytically dead pseudokinase activates LKB1
    • Physiological inputs controlling complex activity not yet defined
  2. 2003 High

    Identified STRADA as an LKB1-specific pseudokinase adaptor that controls LKB1 nuclear-cytoplasmic localization and is required for LKB1-induced G1 arrest, linking complex assembly to tumor suppression.

    Evidence Reciprocal Co-IP of endogenous complex, subcellular fractionation, siRNA knockdown with cell-cycle readout, and a Peutz-Jeghers LKB1 binding mutant

    PMID:12805220

    Open questions at the time
    • Structural basis of LKB1 activation unknown
    • Mechanism of nuclear export not defined
  3. 2004 High

    Showed STRADA-driven LKB1 activation is sufficient to polarize single epithelial cells, establishing the complex as a cell-autonomous master regulator of apicobasal polarity independent of cell-cell contact.

    Evidence Inducible STRAD expression in intestinal epithelial lines with immunofluorescence and electron microscopy

    PMID:15016379

    Open questions at the time
    • Downstream effectors of polarization not identified at this stage
    • Role of AMPK vs other LKB1 substrates unresolved
  4. 2004 High

    Defined the assembly logic of the complex and demonstrated that LKB1 activation is phosphorylation-independent and that STRADA ATP binding, though high affinity, is dispensable for activation.

    Evidence Systematic mutagenesis of 34 LKB1 cancer mutants, Co-IP binding assays, in vitro kinase assays, and ATP-binding assays

    PMID:15561763

    Open questions at the time
    • Function of STRADA ATP binding left unexplained
    • Atomic basis of two-site MO25 interaction not yet visualized
  5. 2005 Medium

    Began to define metabolic regulation of the complex, showing acyl-CoA lipids modulate AMPKK activity in a substrate-specific manner.

    Evidence In vitro kinase assays with recombinant complex and dose-response analysis of palmitoyl-CoA

    PMID:15644453

    Open questions at the time
    • Substrate-specific lipid effect not independently replicated
    • Physiological relevance in cells not established
  6. 2006 Medium

    Extended metabolic regulation by showing glycolytic intermediates and ADP tune complex activity toward AMPK, linking energy state to LKB1/STRAD/MO25 output.

    Evidence In vitro kinase assays with recombinant complex against an array of metabolites

    PMID:16985256

    Open questions at the time
    • In vitro only; cellular metabolite sensing not demonstrated
    • Single lab
  7. 2007 High

    Demonstrated a neuronal role for STRADA in axon specification and showed it stabilizes LKB1 protein and promotes its phosphorylation, connecting complex assembly to neurodevelopment.

    Evidence siRNA knockdown and overexpression with live imaging in hippocampal and cortical neurons plus phosphorylation analysis

    PMID:17482549

    Open questions at the time
    • Mechanism linking LKB1 stabilization to axogenesis not fully defined
    • Relevant downstream LKB1 substrate kinases in neurons not pinpointed here
  8. 2007 Medium

    Connected STRADA loss to human disease, identifying homozygous LYK5/STRADA deletion as the cause of PMSE syndrome with constitutive brain mTOR activation.

    Evidence Autozygosity mapping, copy number analysis, and phospho-S6 immunostaining of patient neuropathology

    PMID:17522105

    Open questions at the time
    • Causal mechanism inferred from genetics plus biomarker, not yet a defined molecular pathway
    • Link between LKB1/AMPK axis and mTOR hyperactivation not directly demonstrated in this study
  9. 2008 Medium

    Resolved how localization couples to function, showing E-cadherin-dependent junction maturation positions the LKB1/STRAD complex to enable AMPK phosphorylation while complex activity itself is junction-independent.

    Evidence Immunostaining, FRET, and E-cadherin junction manipulation with AMPK phosphorylation readout

    PMID:19110428

    Open questions at the time
    • Molecular tether linking STRAD complex to adherens junctions not identified
    • Single lab
  10. 2009 High

    Provided the structural mechanism: the LKB1-STRADα-MO25α crystal structure showed STRADα adopts a closed conformation and binds LKB1 as a pseudosubstrate, with MO25α stabilizing LKB1's active state phosphorylation-independently.

    Evidence X-ray crystallography of the heterotrimer with functional validation of Peutz-Jeghers and cancer mutations

    PMID:19892943

    Open questions at the time
    • Conformational dynamics and substrate handoff to AMPK not captured
    • How metabolic ligands feed into this architecture unresolved
  11. 2009 High

    Mapped a polarity effector branch, defining a MO25α-Mst4-Ezrin axis downstream of the complex that specifically drives brush-border formation.

    Evidence Co-IP, live-cell imaging of Mst4 translocation, in vitro Ezrin T567 kinase assay, and inhibitor phenotyping

    PMID:19386264

    Open questions at the time
    • How LKB1 activation triggers Mst4 relocalization not fully defined
    • Separation from lateral junction pathway only partially explained
  12. 2010 High

    Used genetic epistasis in C. elegans to dissect which LKB1 functions require STRADA, showing the AMPK/quiescence arm is STRAD-dependent while early-embryo polarity is STRAD-independent.

    Evidence Genetic epistasis of strd-1 and par-4 mutants with AMPK phosphorylation and developmental phenotype analysis

    PMID:20110331

    Open questions at the time
    • Molecular basis for STRAD-independent LKB1 polarity activity unknown
    • Mammalian generality of this division not tested here
  13. 2013 High

    Established that STRADA loss causes constitutive mTORC1 activation and neural progenitor migration/lamination defects that are pharmacologically reversible, defining the actionable disease mechanism of PMSE.

    Evidence siRNA knockdown in neural progenitors, rapamycin/p70S6K-inhibitor rescue in vitro and in utero, and PMSE patient fibroblast validation

    PMID:23616120

    Open questions at the time
    • Precise step from LKB1/AMPK loss to mTORC1 hyperactivation not mechanistically dissected
    • Long-term in vivo therapeutic outcomes not addressed
  14. 2014 Medium

    Distinguished paralog-specific roles, showing both STRADα and STRADβ support axogenesis but only STRADα maintains LKB1 stability via cytoplasmic compartmentalization.

    Evidence In vivo cortical electroporation with shRNA against STRADα vs STRADβ and protein/localization analysis

    PMID:24594058

    Open questions at the time
    • Structural basis of the α-specific stabilization not defined
    • Single lab
  15. 2022 Medium

    Identified a physiological regulator that disrupts the complex, with intracellular midkine binding LKB1 and STRAD to dismantle the heterotrimer and blunt AMPK activation in cancer cells.

    Evidence Co-IP of MDK with LKB1 and STRAD, LKB1 in vitro kinase assays, AMPK phosphorylation under glucose starvation/2-DG, and proliferation assays

    PMID:35487917

    Open questions at the time
    • Binding interface and stoichiometry of MDK disruption not resolved
    • Single lab, not independently replicated
  16. 2022 Medium

    Demonstrated druggability, showing small molecules occupying the STRAD pseudokinase ATP pocket allosterically modulate LKB1 activity.

    Evidence Medium-throughput ligand screening with direct LKB1 kinase activity assays

    PMID:35525550

    Open questions at the time
    • No high-affinity lead or structural binding mode reported
    • Cellular and in vivo activity not shown
  17. 2033 Medium

    Extended the developmental mTORC1 link to human tissue, showing STRADA loss perturbs forebrain neurogenesis and interneuron fate in a rapamycin-reversible manner.

    Evidence STRADA knockout human dorsal and ventral forebrain organoids with rapamycin rescue and cell-type composition analysis

    PMID:41791387

    Open questions at the time
    • Cell-type-specific effectors downstream of mTORC1 not defined
    • Single model system

Open questions

Synthesis pass · forward-looking unresolved questions
  • How metabolic ligand sensing, junction localization, and physiological complex-disruptors are integrated to set LKB1 output in different tissues, and whether STRAD-pocket ligands can therapeutically tune LKB1/mTORC1 in disease, remains unresolved.
  • No unified model linking metabolite regulation to in vivo physiology
  • Therapeutic translation of allosteric STRAD ligands unproven

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0140096 catalytic activity, acting on a protein 4 GO:0060090 molecular adaptor activity 2 GO:0140657 ATP-dependent activity 2
Localization
GO:0005829 cytosol 2 GO:0005886 plasma membrane 2 GO:0005634 nucleus 1
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-162582 Signal Transduction 3 R-HSA-1430728 Metabolism 2 R-HSA-8953897 Cellular responses to stimuli 2
Partners
CAB39MARK3MDKSTK11STRADB
Complex memberships
LKB1-STRAD-MO25 heterotrimer

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2003 STRADA (STRADα/β) forms a complex with LKB1 and MO25α/β that functions as an upstream kinase (AMPKK) activating AMPK by phosphorylating Thr172 of AMPK. Catalytically active LKB1, STRADα or STRADβ, and MO25α or MO25β are all required for full AMPKK activity. The complex was purified from rat liver and shown to immunoprecipitate with anti-LKB1 antibodies. Biochemical purification from rat liver, immunoprecipitation, in vitro kinase assay, recombinant complex reconstitution, stable expression of wild-type vs. catalytically inactive LKB1 in HeLa cells, LKB1-knockout mouse embryo fibroblasts Journal of biology High 14511394
2003 STRADA is an LKB1-specific adaptor and pseudokinase (STE20-like kinase domain lacking catalytic residues) that binds LKB1, activates LKB1 kinase activity, and determines subcellular localization of wild-type LKB1 by translocating it from the nucleus to the cytoplasm. Removal of endogenous STRAD by siRNA abrogated LKB1-induced G1 arrest. A Peutz-Jeghers LKB1 mutation that does not compromise LKB1 kinase activity was shown to interfere with LKB1 binding to STRAD. Co-immunoprecipitation of endogenous complex, in vitro kinase assay, subcellular fractionation/localization, siRNA knockdown with cell-cycle readout, characterization of PJS patient mutation The EMBO journal High 12805220
2004 Activation of LKB1 by STRAD in single intestinal epithelial cells is sufficient to induce complete apicobasal polarization, including actin remodeling to form an apical brush border, redistribution of junctional proteins ZO-1 and p120, and sorting of apical and basolateral markers — all in the absence of cell-cell contacts. Inducible STRAD expression in intestinal epithelial cell lines, immunofluorescence, electron microscopy Cell High 15016379
2004 Twelve of 34 LKB1 cancer-associated point mutants fail to interact with STRAD-MO25. Two binding sites on opposite surfaces of MO25α are required for assembly of the MO25α-STRADα-LKB1 complex. LKB1 does not require phosphorylation of its own T-loop to be activated by STRADα-MO25α. STRADα, despite being catalytically inactive, binds ATP with high affinity, but this ATP binding is not required for LKB1 activation. Mutagenesis of 34 LKB1 cancer mutants, Co-IP binding assays, in vitro kinase assay, ATP-binding assays Journal of cell science High 15561763
2005 Long-chain acyl-CoA esters (LCACEs), specifically palmitoyl-CoA, inhibit the AMPKK activity of the recombinant LKB1/STRAD/MO25 complex toward AMPK (Thr172 phosphorylation) in a substrate-specific manner — palmitoyl-CoA paradoxically stimulates LKB1/STRAD/MO25 activity toward the peptide substrate LKBtide but inhibits phosphorylation of full-length AMPK. In vitro kinase assay with recombinant LKB1/STRAD/MO25 and purified rat liver AMPKK, dose-response analysis with palmitoyl-CoA and related lipids American journal of physiology. Endocrinology and metabolism Medium 15644453
2006 3-phosphoglycerate (3-PG) stimulates LKB1-STRAD-MO25 AMPKK activity toward AMPK (but not toward the peptide substrate LKBtide), increasing AMPK phosphorylation in vitro. ADP inhibits both AMPK activity and LKB1-STRAD-MO25 activity. In vitro kinase assay with recombinant LKB1-STRAD-MO25 and an array of metabolites American journal of physiology. Endocrinology and metabolism Medium 16985256
2007 Accumulation of LKB1 and STRAD in an undifferentiated neurite of cultured hippocampal neurons correlates with subsequent axon differentiation. Downregulation of STRAD by siRNA prevents axon differentiation; overexpression leads to multiple axon formation. STRAD interaction with LKB1 promotes LKB1 phosphorylation at a PKA site (S431) and elevates LKB1 protein levels. siRNA knockdown, overexpression, live imaging in cultured hippocampal neurons and in vivo cortical neurons, phosphorylation analysis Cell High 17482549
2007 Homozygous deletion of exons 9-13 of LYK5/STRADA (encoding a pseudokinase necessary for proper localization and function of LKB1) causes PMSE syndrome (polyhydramnios, megalencephaly, symptomatic epilepsy) with constitutive activation of the mTOR signaling pathway in brain, as evidenced by abundant anti-phospho-ribosomal S6 labeling in affected neurons. SNP microarray autozygosity mapping, copy number analysis, neuropathological examination with immunostaining for phospho-S6 Brain : a journal of neurology Medium 17522105
2008 Active LKB1/STRAD kinase complex colocalizes with E-cadherin at adherens junctions (AJs) in polarized epithelial cells, as shown by immunostaining and FRET. LKB1/STRAD localization and AMPK phosphorylation require E-cadherin-dependent maturation of AJs, but LKB1/STRAD complex kinase activity itself is E-cadherin independent, indicating that E-cadherin regulates AMPK phosphorylation by controlling LKB1/STRAD localization. Immunostaining, FRET, manipulation of E-cadherin junctions, AMPK phosphorylation assay Current biology : CB Medium 19110428
2009 Crystal structure of the core LKB1-STRADα-MO25α heterotrimer reveals an allosteric mechanism of LKB1 activation: STRADα adopts a closed conformation typical of active kinases and binds LKB1 as a pseudosubstrate; STRADα and MO25α promote the active conformation of LKB1; MO25α stabilizes the active conformation by interacting with the LKB1 activation loop. This activation is phosphorylation-independent. X-ray crystallography of heterotrimeric complex, structural analysis, functional validation of mutations identified in Peutz-Jeghers syndrome and sporadic cancers Science (New York, N.Y.) High 19892943
2009 Mo25α interacts with the serine/threonine kinase Mst4 downstream of the LKB1/Strad/Mo25 complex. Upon LKB1 activation, Mst4 translocates from the Golgi to the subapical membrane compartment. Mst4 phosphorylates the regulatory T567 residue of Ezrin, and inhibition of Mst4 blocks LKB1-induced brush border formation (but not lateral junction formation), defining a brush border induction pathway downstream of LKB1/Strad/Mo25. Co-immunoprecipitation (Mo25α-Mst4 interaction), live-cell imaging of Mst4 translocation, in vitro kinase assay (Mst4 phosphorylating Ezrin T567), inhibitor studies Developmental cell High 19386264
2010 In C. elegans, strd-1/STRAD is required for PAR-4/LKB1 to phosphorylate and activate AMPK to regulate germline stem cell quiescence and cell growth/proliferation. However, PAR-4-mediated phosphorylation of polarity regulators PAR-1 and MEX-5 in the early embryo occurs independently of STRD-1, demonstrating that LKB1's polarity function in early embryogenesis is STRAD-independent. Genetic epistasis in C. elegans (strd-1 and par-4 mutants), AMPK phosphorylation assays, dauer/embryo phenotype analysis Development (Cambridge, England) High 20110331
2013 STRADA depletion causes constitutive mTORC1 activation and impairs neural progenitor cell migration in vitro. Rapamycin (mTORC1 inhibitor) or p70S6K inhibitor rescues the migration defect. Rapamycin also rescues aberrant cortical lamination and heterotopia in STRADA-depleted mouse cerebral cortex. Constitutive mTORC1 signaling and migration defects were confirmed in fibroblasts from PMSE patients. siRNA knockdown in mouse neural progenitor cells, rapamycin/p70S6Ki rescue experiments in vitro and in vivo (in utero electroporation), patient-derived fibroblast assays Science translational medicine High 23616120
2014 Both STRADα and STRADβ are sufficient for axogenesis in developing cortical neurons. STRADα specifically maintains LKB1 protein stability via cytoplasmic compartmentalization in vivo — a reciprocal protein-stabilizing relationship between LKB1 and STRADα. STRADβ does not share this stabilization function. In vivo cortical electroporation, shRNA knockdown of STRADα vs. STRADβ, protein level analysis, subcellular localization studies in developing cortex Neural development Medium 24594058
2022 Intracellular midkine (MDK) interacts with LKB1 and STRAD to disrupt the LKB1-STRAD-Mo25 complex, thereby decreasing LKB1 activity and dampening both basal and stress-induced AMPK activation (by glucose starvation or 2-DG treatment), promoting cancer cell proliferation. Co-immunoprecipitation (MDK with LKB1 and STRAD), in vitro kinase assay (LKB1 activity), AMPK phosphorylation assays under glucose starvation/2-DG, cell proliferation assays Cell death & disease Medium 35487917
2022 Small molecules targeting the ATP-binding pocket of the STRAD pseudokinase can allosterically modulate LKB1 kinase activity, demonstrating that STRAD's ATP-binding site is a tractable allosteric regulatory site for the LKB1-STRAD-MO25 complex. Medium-throughput screening of STRAD ligands, direct LKB1 kinase activity assays, comparison of direct vs. indirect assessment methods Methods in enzymology Medium 35525550
2020 STRADA knockout (CRISPR) in mouse N2a cells leads to enhanced mTOR signaling. iPSC-derived neurons from PMSE individuals (STRADA founder mutation) exhibit enhanced cell size and mTOR signaling activation, increased input resistance, more depolarized resting membrane potential, decreased threshold for action potential generation, and ectopic neurons in white matter of Strada-/- mice. CRISPR knockout cells, iPSC-derived neurons from PMSE patients, electrophysiology, immunostaining for phospho-S6, histopathology of Strada-/- mouse brain Frontiers in cellular neuroscience Medium 32457579
2033 STRADA loss (knockout organoids) causes delayed forebrain neurogenesis with progenitor renewal, increased proliferation, expanded outer radial glia, and shifted interneuron subtypes toward neuropeptide-Y-expressing cells. Rapamycin rescues most phenotypes, placing STRADA upstream of mTORC1 in controlling cell fate specification in dorsal and ventral forebrain development. STRADA knockout human brain organoids (dorsal and ventral forebrain), rapamycin rescue, cell type composition analysis Stem cell reports Medium 41791387

Source papers

Stage 0 corpus · 33 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2003 Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. Journal of biology 1343 14511394
2004 Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 422 15016379
2003 Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. The EMBO journal 308 12805220
2007 LKB1/STRAD promotes axon initiation during neuronal polarization. Cell 290 17482549
2009 Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science (New York, N.Y.) 285 19892943
2009 Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Developmental cell 133 19386264
2004 Analysis of the LKB1-STRAD-MO25 complex. Journal of cell science 129 15561763
2007 Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5. Brain : a journal of neurology 103 17522105
2013 Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder. Science translational medicine 102 23616120
2008 Regulation of LKB1/STRAD localization and function by E-cadherin. Current biology : CB 61 19110428
2005 Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25. American journal of physiology. Endocrinology and metabolism 52 15644453
2021 STRADA-mutant human cortical organoids model megalencephaly and exhibit delayed neuronal differentiation. Developmental neurobiology 31 33619909
2010 Allosteric protein kinase regulation by pseudokinases: insights from STRAD. Science signaling 29 20197543
2010 Differential requirements for STRAD in LKB1-dependent functions in C. elegans. Development (Cambridge, England) 28 20110331
2022 Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex. Cell death & disease 25 35487917
2016 Whole exome sequencing identifies the first STRADA point mutation in a patient with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE). American journal of medical genetics. Part A 25 27170158
2014 STRAD pseudokinases regulate axogenesis and LKB1 stability. Neural development 21 24594058
2005 Evidence against regulation of AMP-activated protein kinase and LKB1/STRAD/MO25 activity by creatine phosphate. American journal of physiology. Endocrinology and metabolism 21 16278246
2020 Multimodal Analysis of STRADA Function in Brain Development. Frontiers in cellular neuroscience 18 32457579
2005 STRAD in Peutz-Jeghers syndrome and sporadic cancers. Journal of clinical pathology 18 16189157
2006 Effects of 3-phosphoglycerate and other metabolites on the activation of AMP-activated protein kinase by LKB1-STRAD-MO25. American journal of physiology. Endocrinology and metabolism 16 16985256
2015 LKB1/Mo25/STRAD uniquely impacts sarcomeric contractile function and posttranslational modification. Biophysical journal 13 25809261
2018 Novel Homozygous Deletion in STRADA Gene Associated With Polyhydramnios, Megalencephaly, and Epilepsy in 2 Siblings: Implications for Diagnosis and Treatment. Journal of child neurology 6 30311510
2021 Homozygous missense STRADA mutation in a patient with polyhydramnios, megalencephaly and symptomatic epilepsy syndrome. Clinical dysmorphology 5 33605605
2024 Severe interstitial lung disease risk prediction in anti-melanoma differentiation-associated protein 5 positive dermatomyositis: the STRAD-Ro52 model. Annals of medicine 4 39697063
2020 Sevoflurane Postconditioning Reduces Hypoxia-Reoxygenation Injury in H9C2 Embryonic Rat Cardiomyocytes and Targets the STRADA Gene by Upregulating microRNA-107. Medical science monitor : international medical journal of experimental and clinical research 4 32332694
2022 Methods to assess small molecule allosteric modulators of the STRAD pseudokinase. Methods in enzymology 3 35525550
2025 Delayed forebrain excitatory and inhibitory neurogenesis in STRADA-related megalencephaly via mTOR hyperactivity. bioRxiv : the preprint server for biology 1 40462897
2025 NHWD-870 suppresses tumor proliferation via the BRD4/STRADA/CCND1 axis in small cell lung cancer. Lung cancer (Amsterdam, Netherlands) 1 41242286
2023 Electroclinical Features in Two Novel STRADA Patients and a Functional Yeast Assay for the Validation of Missense STRADA Mutations. Pediatric neurology 1 37722301
2026 Delayed forebrain excitatory and inhibitory neurogenesis in STRADA-related megalencephaly via mTOR hyperactivity. Stem cell reports 0 41791387
2026 STRADA deficiency impairs cortical interneuron development in humans and mice. bioRxiv : the preprint server for biology 0 41959176
2025 StraD: a coarse-grained simulation of co-transcriptional RNA folding. NAR genomics and bioinformatics 0 41278539

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