Affinage

SRGAP2

SLIT-ROBO Rho GTPase-activating protein 2 · UniProt O75044

Length
1071 aa
Mass
120.9 kDa
Annotated
2026-06-10
35 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SRGAP2 (SRGAP2A) is a multidomain Rho-family GAP that couples membrane geometry sensing to local control of cytoskeletal dynamics, restraining cell motility and shaping neuronal architecture (PMID:19737524, PMID:26439400). Its inverse F-BAR domain senses and deforms membrane to induce filopodia-like protrusions and pre-localizes the protein to protruding edges, while the RhoGAP domain terminates small-GTPase signaling—primarily Rac1 in migrating cells and contact protrusions, and RhoA/Cdc42 in other cell types—to limit protrusion duration and migration (PMID:19737524, PMID:26439400, PMID:29242313, PMID:35441126). SRGAP2A homodimerizes through an extended interface spanning the F-BAR, a newly defined F-BAR extension (Fx) domain, and RhoGAP-SH3 domains, adopting an unusual inverse geometry suited to scaffolding membrane protrusions in lamellipodia and dendritic spine heads (PMID:28333212). Through its SH3 domain it engages partners such as the formin FMNL1, inhibiting FMNL1-mediated actin severing while also being recruited to terminate Rac signaling at the phagocytic cup (PMID:21148482). SRGAP2A activity is tuned by post-translational modification: PRMT5-mediated arginine methylation at Arg-927 controls F-BAR-dependent homodimerization and leading-edge membrane localization (PMID:20810653), and PKCα-mediated phosphorylation at Ser206 transduces ECM stiffness signals into tension gradients that direct durotaxis (PMID:36593959). In the human lineage, the truncated paralogs SRGAP2B/C heterodimerize with SRGAP2A and—being intrinsically unstable—reduce its levels through proteasomal degradation; SRGAP2C-specific arginine substitutions and a functional Fx domain make it a more effective inhibitor that drives increased synapse density and protracted synaptic maturation (neoteny) in human cortical neurons and microglia, in part by raising postsynaptic SYNGAP1 against which SRGAP2A reciprocally antagonizes (PMID:22559944, PMID:28333212, PMID:31822692, PMID:39406239). Across non-neuronal contexts SRGAP2 functions broadly as a brake on GTPase-driven remodeling—restraining podocyte motility, osteoclastogenesis, and endothelial barrier opening (PMID:29242313, PMID:31880824, PMID:35441126).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 2009 High

    Established the founding function of srGAP2: its F-BAR domain deforms membrane to generate filopodia and the protein acts as a negative regulator of neuronal migration while promoting neurite branching.

    Evidence In utero electroporation knockdown/overexpression in mouse neocortex plus in vitro membrane deformation assays

    PMID:19737524

    Open questions at the time
    • Did not define which GTPase the GAP domain targets in this context
    • Membrane curvature sensing versus generation not structurally resolved
  2. 2010 High

    Connected srGAP2 to a specific actin effector, showing SH3-domain binding to FMNL1 inhibits actin severing and that Rac-activated FMNL1 recruits srGAP2 to terminate Rac signaling at the phagocytic cup.

    Evidence Co-IP, in vitro actin severing assays, and domain mapping in macrophage-derived cells

    PMID:21148482

    Open questions at the time
    • FMNL1 interaction not validated in neurons
    • Feedback loop kinetics not quantified
  3. 2010 High

    Identified PRMT5-mediated arginine methylation at Arg-927 as a regulatory switch controlling F-BAR-dependent dimerization and membrane targeting, linking a post-translational modification to localization and cell spreading.

    Evidence Co-IP, R927A site-directed mutagenesis, localization, and cell-spreading rescue assays

    PMID:20810653

    Open questions at the time
    • Physiological stimuli regulating methylation unknown
    • Effect on GAP activity not tested
  4. 2012 High

    Defined the human-specific paralog mechanism: SRGAP2C dimerizes with SRGAP2A to inhibit it, phenocopying SRGAP2 deficiency and producing synaptic neoteny.

    Evidence Reciprocal Co-IP and in utero electroporation of SRGAP2C/shRNA with spine morphology analysis in mouse neocortex

    PMID:22559944

    Open questions at the time
    • Structural basis of inhibitory heterodimer not resolved at this stage
    • Mechanism reducing SRGAP2A function not yet defined as degradation
  5. 2012 High

    Distinguished the membrane-deformation properties of the three srGAP F-BAR paralogs and showed they heterodimerize and act synergistically, and that F-BAR(2) binds anionic phospholipids broadly.

    Evidence Expression in COS7/cortical neurons, FRAP, phosphoinositide depletion, lipid-binding assays, and Co-IP

    PMID:22467852

    Open questions at the time
    • Functional consequence of srGAP1/2/3 heterodimers in vivo unclear
    • Lipid specificity determinants not mapped
  6. 2013 Medium

    Showed srGAP2 inhibits neurite outgrowth via interaction with srGAP3 and that the F-BAR domain alone is sufficient for some effects, refining its role in neuronal differentiation.

    Evidence Knockdown/overexpression, GAP-domain point mutants, and Co-IP in Neuro2a cells

    PMID:23505444

    Open questions at the time
    • Conducted in a neuroblastoma cell line rather than primary neurons
    • Separation of differentiation versus outgrowth effects incomplete
  7. 2015 Medium

    Resolved the SH3-domain ligand-binding logic, explaining how weak isolated affinity is converted into specific partner selection through a two-component tightening/autoinhibition mechanism.

    Evidence Structural analysis, mutagenesis, and binding affinity measurements

    PMID:26365803

    Open questions at the time
    • Specific physiological ligands governed by this mechanism not enumerated
    • Full method detail not specified in abstract
  8. 2015 High

    Placed srGAP2 in the Slit2-Robo4 axis controlling contact inhibition of locomotion, showing F-BAR curvature sensing pre-localizes srGAP2 to terminate Rac1 activity specifically in contact protrusions.

    Evidence FRET Rac1 biosensor, knockdown, F-BAR overexpression, and live imaging of cell collisions in fibroblasts

    PMID:26439400

    Open questions at the time
    • How Robo4 engages srGAP2 molecularly not defined
    • Selectivity for contact versus contact-free protrusions mechanistically unexplained
  9. 2017 High

    Provided the structural basis for dimerization and human-specific inhibition: a crystal structure revealed the F-BAR/Fx/RhoGAP-SH3 dimer interface and inverse geometry, and showed SRGAP2C's defective Fx domain makes SRGAP2A:SRGAP2C heterodimers insoluble, inhibiting SRGAP2A.

    Evidence X-ray crystallography with biochemical reconstitution and dimerization/solubility assays

    PMID:28333212

    Open questions at the time
    • In-cell consequences of insoluble heterodimers not directly imaged
    • Membrane-bound conformation not captured
  10. 2017 Medium

    Extended the GAP function beyond neurons, showing SRGAP2A restrains podocyte motility via RhoA/Cdc42 (not Rac1) inactivation and protects against diabetic podocyte injury.

    Evidence Co-localization with synaptopodin, GTPase activity assays, podocyte migration, adenoviral rescue in db/db mice, and zebrafish knockdown

    PMID:29242313

    Open questions at the time
    • GTPase selectivity switch (RhoA/Cdc42 vs Rac1) across cell types unexplained
    • Direct GAP activity on RhoA/Cdc42 not biochemically isolated
  11. 2019 High

    Defined the degradative mechanism of paralog antagonism: unstable SRGAP2B/C reduce SRGAP2A protein via the proteasome upon heterodimerization, and SRGAP2C-specific arginine substitutions confer uniquely durable synaptic neoteny.

    Evidence Co-IP, proteasome inhibitor rescue, and in utero electroporation with synaptic density time courses

    PMID:31822692

    Open questions at the time
    • E3 ligase mediating SRGAP2A degradation unidentified
    • Why SRGAP2C but not SRGAP2B sustains the effect not fully mechanistic
  12. 2020 High

    Demonstrated Srgap2 as a Rac1-specific GAP brake on osteoclastogenesis and clastokine SLIT3 expression during inflammation, generalizing its motility/differentiation-restraining role to bone biology.

    Evidence Myeloid conditional knockout, Rac1 activation assays, osteoclastogenesis, bone histomorphometry, and conditioned medium experiments

    PMID:31880824

    Open questions at the time
    • Link between GAP activity and SLIT3 transcriptional control unclear
    • Whether human paralogs modulate this myeloid role untested
  13. 2022 Medium

    Showed srGAP2 deactivates RhoA after agonist-induced endothelial contraction to restore barrier integrity, identifying a vascular role distinct from basal barrier maintenance.

    Evidence Knockdown, transendothelial resistance, RhoA activity assays, and pharmacological perturbations in endothelial cells

    PMID:35441126

    Open questions at the time
    • Single-lab study
    • Recruitment of srGAP2 to junctions after contraction not visualized
  14. 2022 Medium

    Reported a non-canonical mitochondrial role, with SRGAP2 interacting with complex I and supporting respiration and chemoresistance in colorectal cancer cells.

    Evidence Co-IP, mitochondrial fractionation, respiration assays, knockdown, and chemosensitivity assays

    PMID:36059022

    Open questions at the time
    • No mutagenesis or structural validation of the complex I interaction
    • How a membrane-deforming GAP localizes to mitochondria unexplained
  15. 2023 Medium

    Identified mechanotransduction control of srGAP2: PKCα phosphorylation at Ser206 downstream of SDC4 generates intramolecular tension gradients that direct durotaxis in breast cancer cells.

    Evidence srGAP2 tension FRET probe, Ser206 phosphomimetic/phosphodeficient mutants, invasion assays, and xenografts

    PMID:36593959

    Open questions at the time
    • Effect of Ser206 phosphorylation on GAP activity not measured
    • Single-lab study
  16. 2024 Medium

    Extended human-specific neoteny beyond neurons to microglia, showing SRGAP2B/C are necessary and sufficient cell-autonomously for microglial maturation neoteny and non-cell-autonomously affect cortical synaptic development.

    Evidence Xenotransplantation of hiPSC-derived microglia plus mouse KD/KO and maturation assays (preprint)

    PMID:38979266

    Open questions at the time
    • Preprint, single lab
    • Molecular target of paralog action in microglia not defined
  17. 2024 High

    Defined a molecular partner for setting synaptogenic tempo: SRGAP2B/C reduce synaptic SRGAP2A, increasing postsynaptic SYNGAP1, and reciprocal SRGAP2A-SYNGAP1 antagonism is tipped toward neoteny in human neurons.

    Evidence Xenotransplanted human cortical neurons with combinatorial LOF (SRGAP2A, SYNGAP1, SRGAP2B/C) and synaptic protein quantification

    PMID:39406239

    Open questions at the time
    • Direct physical/biochemical link between SRGAP2A and SYNGAP1 not established
    • Whether antagonism is competitive at a shared site unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SRGAP2A's GTPase selectivity (Rac1 vs RhoA/Cdc42) is switched across cell types, and the identity of the E3 ligase driving paralog-induced SRGAP2A degradation, remain unresolved.
  • No mechanism reconciling Rac1-specific versus RhoA/Cdc42-directed GAP activity
  • Degradation machinery for SRGAP2A unidentified
  • Mitochondrial localization mechanism unexplained

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 6 GO:0008092 cytoskeletal protein binding 2 GO:0060089 molecular transducer activity 2 GO:0008289 lipid binding 1
Localization
GO:0005886 plasma membrane 4 GO:0005856 cytoskeleton 2 GO:0005739 mitochondrion 1
Partners
FMNL1PRMT5ROBO4SDC4SRGAP2BSRGAP2CSRGAP3SYNGAP1
Complex memberships
SRGAP2A homodimerSRGAP2A:SRGAP2B heterodimerSRGAP2A:SRGAP2C heterodimer

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2009 The F-BAR domain of srGAP2 induces filopodia-like membrane protrusions (resembling I-BAR domain activity) in vivo and in vitro, negatively regulates neuronal migration, and promotes neurite outgrowth and branching. srGAP2 knockdown reduces leading process branching and increases neuronal migration rate in vivo. In utero electroporation knockdown and overexpression in mouse neocortex; in vitro membrane deformation assays; F-BAR domain expression in non-neuronal cells Cell High 19737524
2012 SRGAP2C, a human-specific truncated paralog encoding only an F-BAR domain, dimerizes with ancestral SRGAP2 (SRGAP2A) to inhibit its function. In mouse neocortex, SRGAP2A promotes spine maturation and limits spine density; expression of SRGAP2C phenocopies SRGAP2 deficiency, leading to increased density of longer, less mature spines (neoteny) and sustained radial migration. Co-immunoprecipitation of SRGAP2C with SRGAP2A; in utero electroporation of SRGAP2C or SRGAP2 shRNA in mouse neocortex; spine morphology analysis Cell High 22559944
2010 srGAP2 forms a complex with the formin FMNL1 (FRL1/FRLα); Rac-mediated activation of FMNL1 recruits srGAP2, whose Rac-specific GAP domain then terminates Rac signaling; additionally, the SH3 domain of srGAP2 binds the FH1 domain of FMNL1 to directly inhibit FMNL1-mediated actin severing. Both proteins co-localize to the phagocytic cup. Co-immunoprecipitation; in vitro actin severing assays; domain mapping; fluorescence microscopy in macrophage-derived cells The Journal of biological chemistry High 21148482
2010 srGAP2 is arginine-methylated at Arg-927 by PRMT5, which binds to the N-terminal region (aa 225–538) of srGAP2. The R927A methylation mutant fails to localize to the plasma membrane leading edge, cannot rescue cell spreading, and disrupts F-BAR domain-mediated srGAP2 homodimerization, linking arginine methylation to membrane localization and cell spreading. Co-immunoprecipitation; domain mapping; site-directed mutagenesis (R927A); subcellular fractionation/fluorescence localization; cell spreading assays with rescue experiments The Journal of biological chemistry High 20810653
2012 The F-BAR domains of srGAP1, srGAP2, and srGAP3 have distinct membrane deformation properties; F-BAR(2) (srGAP2) and F-BAR(3) induce filopodia while F-BAR(1) prevents filopodia in cortical neurons. The three F-BAR domains can heterodimerize and act synergistically in filopodia induction. F-BAR(2) membrane dynamics are partially dependent on F-actin. F-BAR(2) binds negatively charged phospholipids including PtdSer broadly, and PtdIns(4,5)P2 depletion does not displace it from the membrane. Expression in COS7 cells and cortical neurons; FRAP; phosphoinositide depletion; phospholipid-binding assays; Co-immunoprecipitation of heterodimerization Journal of cell science High 22467852
2015 The Slit2-Robo4-srGAP2 signaling axis regulates contact inhibition of locomotion (CIL) in fibroblasts. The srGAP2 F-BAR domain senses membrane curvature to pre-localize srGAP2 to protruding edges, and srGAP2 specifically controls the duration of Rac1 activity in contact protrusions (but not contact-free protrusions) to terminate their extension after cell collision. FRET-based Rac1 biosensor; srGAP2 knockdown; F-BAR domain overexpression; live-cell imaging of collision events; Slit2/Robo4 perturbations Developmental cell High 26439400
2015 srGAP2 uses a two-component molecular mechanism for ligand binding through its SH3 domain: one component dramatically tightens ligand association, the other moderately autoinhibits and restricts binding, achieving specificity despite weak isolated SH3-ligand affinity. Structural analysis; mutagenesis; binding affinity measurements (likely ITC/SPR inferred from structural study context) Structure Medium 26365803
2017 SRGAP2A crystal structure reveals: (1) it homodimerizes through a large interface comprising the F-BAR domain, a newly identified F-BAR extension (Fx) domain, and RhoGAP-SH3 domains; (2) it has an unusual inverse geometry enabling membrane protrusion scaffolding in lamellipodia and dendritic spine heads; (3) SRGAP2C carries a defective Fx domain that severely compromises its solubility and membrane-scaffolding ability; (4) SRGAP2A:SRGAP2C heterodimers form but are insoluble, thereby inhibiting SRGAP2A activity; (5) the primal SRGAP2C (~3.4 Ma) is less effective at heterodimerizing with SRGAP2A than modern SRGAP2C. X-ray crystallography; biochemical reconstitution; cell culture expression assays; dimerization/solubility assays Molecular biology and evolution High 28333212
2019 SRGAP2C and SRGAP2B are intrinsically unstable proteins in neurons; upon heterodimerization with SRGAP2A they reduce SRGAP2A protein levels in a proteasome-dependent manner. SRGAP2C-specific arginine substitutions (non-synonymous mutations) enable it to uniquely induce long-lasting increases in both excitatory and inhibitory synapse density and protracted synapse maturation throughout adulthood, unlike SRGAP2B. Co-immunoprecipitation; proteasome inhibitor experiments; in utero electroporation; spine/synapse density quantification over developmental time course Scientific reports High 31822692
2017 SRGAP2A is primarily localized in podocytes where it co-localizes with synaptopodin, and suppresses podocyte motility through inactivation of RhoA and Cdc42 (but not Rac1). Overexpression of SRGAP2A in db/db mice via adenovirus mitigates podocyte injury and proteinuria. Immunofluorescence co-localization; Western blot; RhoA/Cdc42/Rac1 activity assays; podocyte migration assays; adenoviral overexpression in diabetic mouse model; zebrafish SRGAP2 knockdown Diabetes Medium 29242313
2020 Srgap2 acts as a Rac1-specific GAP in osteoclasts, limiting osteoclastogenesis during TNFα-driven inflammation. Conditional knockout of Srgap2 in the myeloid lineage strongly enhances Rac1 activation in osteoclast precursors. Srgap2 also restricts osteoclast expression of the paracrine clastokine SLIT3, which promotes osteoblast differentiation. Myeloid-specific conditional knockout (Srgap2 f/f:LysM-Cre); Rac1 activation assays; in vitro osteoclastogenesis; bone histomorphometry; conditioned medium experiments; Western blot Journal of bone and mineral research High 31880824
2022 srGAP2 acts to deactivate RhoA signaling after thrombin-induced endothelial contraction, allowing cell respreading and restoration of the endothelial barrier. Depletion of srGAP2 increases the magnitude and duration of junctional opening in response to thrombin, TNFα, and angiotensin II. srGAP2 is not required for basal barrier function in resting endothelial cells. srGAP2 knockdown in endothelial cells; transendothelial electrical resistance measurements; RhoA activity assays; pharmacological perturbations Vascular biology Medium 35441126
2022 SRGAP2 physically interacts with mitochondrial complex I in colorectal cancer cells and positively modulates its activity. Loss of mitochondrial SRGAP2 decreases mitochondrial respiration and sensitizes CRC cells to chemotherapy, phenocopied by complex I inhibitor treatment. Co-immunoprecipitation of SRGAP2 with mitochondrial complex I; mitochondrial fractionation; mitochondrial respiration assays; SRGAP2 knockdown; chemosensitivity assays Human cell Medium 36059022
2023 srGAP2 undergoes PKCα-mediated phosphorylation at Ser206 within the F-BAR domain in response to stiff extracellular matrix signals transduced by the mechanoreceptor Syndecan-4 (SDC4). This phosphorylation generates tension gradients within srGAP2 across the cell (higher tension at leading edge), directing persistent cell migration along stiffness gradients (durotaxis) in triple-negative breast cancer cells. srGAP2 tension FRET probe; phosphomimetic/phosphodeficient mutagenesis (Ser206); Transwell invasion assays; xenograft mouse model; membrane protein fractionation; fluorescence imaging Theranostics Medium 36593959
2024 SRGAP2A and its human-specific paralogs SRGAP2B/C are expressed in human microglia. SRGAP2B/C are necessary and sufficient (cell-autonomously) to induce neotenic features of microglial structural and functional maturation, and this neoteny non-cell-autonomously impacts synaptic development in cortical pyramidal neurons. Xenotransplantation of hiPSC-derived microglia into mouse cortex; mouse genetic models (KD/KO); morphological and functional maturation assays of microglia bioRxivpreprint Medium 38979266
2024 SRGAP2A levels at synapses are reduced by SRGAP2B/C, leading to increased postsynaptic accumulation of SYNGAP1. The tempo of synaptogenesis is set by reciprocal antagonism between SRGAP2A and SYNGAP1, and this balance is tipped toward neoteny in human cortical pyramidal neurons by SRGAP2B/C. Human cortical pyramidal neurons xenotransplanted into mouse cortex; combinatorial loss-of-function (SRGAP2A, SYNGAP1, SRGAP2B/C); synaptic density and maturation quantification; Western blot for synaptic protein levels Neuron High 39406239
2013 srGAP2 inhibits neuronal differentiation and neurite outgrowth through interaction with srGAP3; the isolated F-BAR domain of srGAP2 (but not srGAP1 or srGAP3 F-BAR) can promote VPA-induced neurite initiation. Knockdown of endogenous srGAP2 promotes neurite outgrowth in differentiated cells without facilitating initial neuronal differentiation. srGAP2 knockdown and overexpression in mouse Neuro2a cells; RhoGAP-defective mutant expression; GAP-domain point mutants; co-immunoprecipitation of srGAP family interactions PloS one Medium 23505444

Source papers

Stage 0 corpus · 35 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation. Cell 328 22559944
2012 Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication. Cell 296 22559943
2009 The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Cell 293 19737524
2017 Dissection of Glomerular Transcriptional Profile in Patients With Diabetic Nephropathy: SRGAP2a Protects Podocyte Structure and Function. Diabetes 93 29242313
2003 FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. International journal of molecular medicine 71 12736724
2015 SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion. Developmental cell 65 26439400
2012 The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently. Journal of cell science 64 22467852
2019 The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development. Scientific reports 50 31822692
2010 Bi-modal regulation of a formin by srGAP2. The Journal of biological chemistry 42 21148482
2010 srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization. The Journal of biological chemistry 40 20810653
2013 The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells. PloS one 36 23505444
2017 Structural History of Human SRGAP2 Proteins. Molecular biology and evolution 32 28333212
2011 Early infantile epileptic encephalopathy associated with the disrupted gene encoding Slit-Robo Rho GTPase activating protein 2 (SRGAP2). American journal of medical genetics. Part A 29 22106086
2020 Rac1 Inhibition Via Srgap2 Restrains Inflammatory Osteoclastogenesis and Limits the Clastokine, SLIT3. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 25 31880824
2022 Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2. Journal of immunology research 24 36277474
2015 The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism. Structure (London, England : 1993) 17 26365803
2023 Urinary exosomes from patients with diabetic kidney disease induced podocyte apoptosis via microRNA-145-5p/Srgap2 and the RhoA/ROCK pathway. Experimental and molecular pathology 16 37952894
2024 Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition. Neuron 14 39406239
2017 The SRGAP2 SNPs, their haplotypes and G × E interactions on serum lipid traits. Scientific reports 13 28912560
2023 Stiff matrix induced srGAP2 tension gradients control migration direction in triple-negative breast cancer. Theranostics 12 36593959
2017 Cognitive Functions: Human vs. Animal - 4:1 Advantage |-FAM72-SRGAP2-|. Journal of molecular neuroscience : MN 11 28255958
2017 Brain plasticity, cognitive functions and neural stem cells: a pivotal role for the brain-specific neural master gene |-SRGAP2-FAM72-|. Biological chemistry 11 28822221
2016 Molecular symmetry-constrained systematic search approach to structure solution of the coiled-coil SRGAP2 F-BARx domain. Acta crystallographica. Section D, Structural biology 11 27917825
2016 Complex intrachromosomal rearrangement in 1q leading to 1q32.2 microdeletion: a potential role of SRGAP2 in the gyrification of cerebral cortex. Molecular cytogenetics 10 26900403
2023 Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice. Neural regeneration research 6 37056152
2022 Impact of klotho on the expression of SRGAP2a in podocytes in diabetic nephropathy. BMC nephrology 6 35436879
2019 A Novel Divergent Gene Transcription Paradigm-the Decisive, Brain-Specific, Neural |-Srgap2-Fam72a-| Master Gene Paradigm. Molecular neurobiology 6 30685845
2016 Dynamic expression of srGAP2 in cell nuclei and cytoplasm during the differentiation of rat neural stem cells in vitro. Molecular medicine reports 5 27748913
2024 Human-specific paralogs of SRGAP2 induce neotenic features of microglia structural and functional maturation. bioRxiv : the preprint server for biology 4 38979266
2022 SRGAP2 controls colorectal cancer chemosensitivity via regulation of mitochondrial complex I activity. Human cell 4 36059022
2013 Purification, crystallization and preliminary X-ray analysis of the inverse F-BAR domain of the human srGAP2 protein. Acta crystallographica. Section F, Structural biology communications 4 24419634
2024 Zebrafish models of human-duplicated SRGAP2 reveal novel functions in microglia and visual system development. bioRxiv : the preprint server for biology 3 39314374
2022 srGAP2 deactivates RhoA to control the duration of thrombin-mediated endothelial permeability. Vascular biology (Bristol, England) 2 35441126
2016 Evolution of the SRGAP2 Gene Is Linked to Intelligence in Mammals. Biomedicine hub 2 31988884
2025 Cell cycle-regulated expression of Fam72a from the |Srgap2-Fam72a| master gene leads to Mis18a downregulation. Cell cycle (Georgetown, Tex.) 0 41414706

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