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Showing NCOR2 — SMRT is a alias.

NCOR2

Nuclear receptor corepressor 2 · UniProt Q9Y618

Length
2514 aa
Mass
273.7 kDa
Annotated
2026-06-10
100 papers in source corpus 44 papers cited in narrative 44 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

NCOR2 (SMRT) is a transcriptional corepressor that nucleates a large multi-subunit complex to enforce chromatin-based gene silencing across nuclear receptor and developmental signaling programs (PMID:10944117, PMID:10809664). It assembles a core repression module with HDAC3, TBL1/TBLR1, and GPS2, whose architecture and stoichiometry have been defined structurally (PMID:10809664, PMID:21240272); within this complex NCOR2 is not a passive scaffold but an obligate activator of HDAC3, supplying a SANT-containing deacetylase-activating domain (DAD) that is necessary and sufficient to reconstitute HDAC3 enzymatic activity from purified components (PMID:11509652). NCOR2 is recruited to chromatin through tandem CoRNR-box receptor interaction domains that engage unliganded nuclear receptors (TR, RAR, AR, VDR, PXR, ERα) (PMID:8755515, PMID:12441355, PMID:19098224), and through dedicated repression domains that bind the BCL6 BTB/POZ homodimer—a contact resolved at 2.2 Å—and other transcription factors including STAT5 and C/EBPβ/Nrf2 (PMID:14690607, PMID:11726519, PMID:15870285). The number of CoRNR-box motifs, set by alternative splicing, tunes receptor-complex selectivity (PMID:18752469). Its repressive output is reversibly disabled by phosphorylation: MAPK/MEKK1, IKKα, CaMKII, and Cdk2/Pin1 cascades phosphorylate NCOR2 to drive nuclear export, dimer disassembly, or degradation, and TBL1/TBLR1-coupled ubiquitylation dismisses the complex to permit corepressor-to-coactivator exchange (PMID:10938135, PMID:15494311, PMID:18374649, PMID:22888005). In vivo, NCOR2 acting through its receptor interaction domains sets the adipogenic and mitochondrial-oxidative set point and, redundantly with NCOR1, controls hepatic lipid homeostasis, RA-dependent Fgf8 repression in somitogenesis, GABAergic neuronal excitability and memory, and B-cell differentiation and genomic integrity (PMID:19066220, PMID:27506116, PMID:30664766, PMID:25421714, PMID:36316474, PMID:34390859). NCOR2 is also co-opted in disease, repressing IRF-1-dependent interferon and proapoptotic genes via HDAC3 to limit antitumor immunity (PMID:35618935).

Mechanistic history

Synthesis pass · year-by-year structured walk · 22 steps
  1. 1996 Medium

    Established NCOR2/SMRT as a ubiquitous nuclear factor that binds unliganded nuclear receptors and represses their target genes, defining its founding role as a hormone-receptor corepressor.

    Evidence Co-IP and reporter assays in transfected mammalian cells, plus antirepressor activity of the receptor-interacting domain

    PMID:8755515

    Open questions at the time
    • Did not define the repression machinery downstream of receptor binding
    • Mechanism of silencing unknown
  2. 1997 High

    Connected NCOR2's repressive output to histone deacetylation by showing it bridges receptors to an mSin3A/HDAC1 complex, providing the first enzymatic mechanism for corepression.

    Evidence Reciprocal co-IP and reporter assays with HDAC inhibitors (TR/RAR systems); parallel deletion mapping of two receptor-interaction and two repression domains

    PMID:9150137 PMID:9415406

    Open questions at the time
    • HDAC1/Sin3 later shown to be a minor partner relative to HDAC3
    • Stoichiometry and complex composition not resolved
  3. 1998 High

    Extended corepressor recruitment beyond nuclear receptors to BTB/POZ transcription factors by showing BCL6-mediated repression requires direct SMRT interaction.

    Evidence Y2H, mammalian two-hybrid, GST pulldown, co-localization, and reporter assays

    PMID:9824158

    Open questions at the time
    • Structural basis of the SMRT-BTB contact not yet defined
    • In vivo BCL6 target gene consequences not tested
  4. 2000 High

    Identified the physiological core complex as a ~1.5–2 MDa assembly of SMRT/N-CoR with HDAC3 and TBL1, and showed TBL1 bridges to histone H3 and potentiates repression, reframing the central enzymatic partner from HDAC1 to HDAC3.

    Evidence Immunoaffinity purification of HeLa nuclear complexes, in vitro receptor binding, antibody microinjection in Xenopus, histone-interaction and reporter assays

    PMID:10809664 PMID:10944117

    Open questions at the time
    • How SMRT confers HDAC3 activity not yet explained
    • Subunit stoichiometry unresolved
  5. 2001 High

    Defined NCOR2 as an obligate allosteric activator of HDAC3 via its SANT-containing DAD, explaining why HDAC3 is catalytically inert without the corepressor.

    Evidence In vitro reconstitution with purified components, HDAC assays, and DAD mutagenesis

    PMID:11509652

    Open questions at the time
    • In vivo requirement of DAD-driven activity for specific genes not yet tested
    • Structural mechanism of activation not solved here
  6. 2001 Medium

    Showed NCOR2 also regulates class IIa HDACs and non-receptor factors, translocating HDAC4 to nuclear domains to silence MEF2C, and repressing STAT5, broadening its target factor repertoire.

    Evidence Immunofluorescence, nuclear fractionation, co-IP, Y2H, and reporter assays (MEF2C/HDAC4-5; STAT5)

    PMID:11304536 PMID:11726519

    Open questions at the time
    • Single-lab functional assays
    • In vivo significance for muscle/cytokine programs not established
  7. 2003 High

    Provided the atomic basis of corepressor recruitment by solving the BCL6 BTB homodimer bound to two symmetric SMRT peptides.

    Evidence 2.2 Å X-ray crystallography with biochemical and in vivo functional validation

    PMID:14690607

    Open questions at the time
    • Structure limited to a short SMRT fragment
    • Does not address full-complex assembly
  8. 2004 High

    Established phosphorylation as the master switch turning off NCOR2 repression, with MEKK1/MAPK and IKKα cascades driving nuclear export and chromatin loss of SMRT-HDAC3 to license NF-κB and other activation; NCOR1 is refractory, defining functional divergence of the paralogs.

    Evidence Kinase assays, ChIP, nonphosphorylatable mutants, nuclear export and fractionation, reporter assays; CK2 site mapping

    PMID:10938135 PMID:11451368 PMID:15491994 PMID:15494311

    Open questions at the time
    • Full repertoire of relevant kinases not enumerated
    • Quantitative dynamics of export vs degradation not resolved
  9. 2004 High

    Demonstrated in vivo developmental corepression by showing unliganded TR recruits N-CoR/SMRT-TBLR1 to chromatinized targets, with T3-induced dismissal driving metamorphic gene activation.

    Evidence Frog oocyte chromatin injection and ChIP across metamorphosis with dominant-negative constructs

    PMID:15060155

    Open questions at the time
    • Direct genetic loss-of-function not performed in this system
    • Mammalian developmental relevance addressed later
  10. 2006 High

    Refined the IKKα switch by showing SMRT remains NF-κB-bound after phosphorylation but selectively loses HDAC3, enabling p300 acetylation of RelA, distinguishing complex remodeling from wholesale dismissal.

    Evidence ChIP/re-ChIP and phospho-mutant functional assays

    PMID:16382138

    Open questions at the time
    • Single-lab system
    • Generality across NF-κB targets not fully mapped
  11. 2008 High

    Connected NCOR2's molecular receptor interactions to organismal physiology by showing its RID-mediated repression sets the adipogenic threshold, with RID-mutant mice developing adiposity and insulin defects.

    Evidence SMRT(mRID) knock-in mice, metabolic phenotyping, MEF differentiation assays

    PMID:19066220

    Open questions at the time
    • Which receptor(s) dominate the adipogenic phenotype not isolated here
    • Tissue-specific contributions unresolved
  12. 2008 High

    Established corepressor dismissal as an active, ubiquitin-coupled step by showing TBL1/TBLR1 phosphorylation triggers NCoR/SMRT ubiquitylation and degradation as a prerequisite for activation; Cdk2/Pin1 separately destabilizes SMRT downstream of ErbB2.

    Evidence ChIP, ubiquitylation assays, siRNA, kinase assays; co-IP, stability and reporter assays for Cdk2-Pin1

    PMID:18374649 PMID:18838553

    Open questions at the time
    • E3 ligase identity in some pathways not defined
    • Cdk2-Pin1 axis single-lab
  13. 2010 Medium

    Linked NCOR2 to mitochondrial oxidative metabolism and aging by showing RID1-selective disabling redirects repression to PPARs, causing premature metabolic disease rescuable by PPAR activation or antioxidants; also showed Erk2 disrupts SMRT homodimerization to remodel the complex.

    Evidence SMRT(mRID1) knock-in mice with ChIP and rescue; sucrose-gradient sedimentation and kinase assays for dimerization

    PMID:20965228 PMID:21109196

    Open questions at the time
    • Dimerization study single-lab in vitro
    • Direct causal PPAR target genes for aging phenotype not fully enumerated
  14. 2011 High

    Resolved the assembly mechanism of the core repression module by determining the TBL1 tetrameric oligomerization domain bound to SMRT and the GPS2-SMRT interface.

    Evidence X-ray crystallography, NMR, docking, mutagenesis, functional assays

    PMID:21240272

    Open questions at the time
    • Full-complex structure including HDAC3 not solved
    • Dynamics of phospho-triggered disassembly not captured
  15. 2012 Medium

    Expanded the kinase-off-switch to Wnt5a/CaMKII-driven SMRT degradation that derepresses Notch1, and established that NCOR2 can also be required for full agonist-dependent ERα activation, revealing a context-dependent coactivator-like role.

    Evidence CaMKII kinase/phospho-mutant, co-IP, fractionation, proteasome assays; ChIP and siRNA for ERα in MCF-7

    PMID:17591692 PMID:22888005

    Open questions at the time
    • Mechanism of ERα coactivation by a corepressor not fully explained
    • Both single-lab
  16. 2014 Medium

    Demonstrated developmental and hematopoietic roles in vivo, with zebrafish ncor2 required for HSC emergence via fos/Vegfd/Notch control, and mouse genetics showing NCoR1 dominates hepatic TH sensitivity while NCoR1/SMRT cooperatively restrain hepatic lipid synthesis.

    Evidence Zebrafish morpholino knockdown with ChIP and pathway epistasis; liver-specific single and double conditional knockout mice

    PMID:25006126 PMID:25421714

    Open questions at the time
    • Zebrafish knockdown is morpholino-based
    • Receptor targets mediating hepatic lipid phenotype only partially defined
  17. 2016 High

    Established direct, redundant developmental corepression in mammals by showing NCOR1/2 are recruited to the Fgf8 RARE to enforce RA-dependent repression during somitogenesis; also revealed viral hijacking of the complex by HPV E8^E2C.

    Evidence CRISPR/Cas9 double knockout with embryo ChIP and RARE deletion; proteomics, co-IP, siRNA and viral replication assays

    PMID:27064408 PMID:27506116

    Open questions at the time
    • Individual contribution of NCOR2 vs NCOR1 not separated in Fgf8 study
    • Viral mechanism is single-system
  18. 2018 High

    Provided structural insight into how SMRT engages class IIa HDACs, showing SRD3c GSI peptides form β-hairpins blocking the HDAC4 catalytic entry without activating its cryptic deacetylase activity—contrasting with HDAC3 activation.

    Evidence X-ray crystallography with structure-guided mutagenesis

    PMID:30321390

    Open questions at the time
    • Functional consequence of class IIa binding in cells not addressed here
    • Single-lab
  19. 2019 High

    Defined a neural circuit function by showing NCoR1/2 loss in GABAergic neurons reduces GABRA2, driving hyperexcitability and impaired LTP through an LH-to-CA3 GABAergic projection controlling memory.

    Evidence Cell-type-specific conditional knockout, optogenetics, electrophysiology, behavior, and rescue manipulations

    PMID:30664766

    Open questions at the time
    • Direct transcriptional regulation of GABRA2 by NCOR2 vs NCOR1 not separated
    • Generality beyond LH-CA3 circuit unknown
  20. 2020 Medium

    Showed HDAC3 activity is dispensable for some in vivo NCOR functions and extended metabolic roles to the heart, where loss of NCOR2 repression elevates PPARα-driven MCUb and impairs cardiac glucose oxidation in diabetes.

    Evidence Epidermal NCoR/SMRT KO and DAD point-mutant knock-in with ChIP-seq; dCas9 promoter pulldown/MS, ChIP, and gene therapy in diabetic hearts

    PMID:32467224 PMID:33303689

    Open questions at the time
    • Cardiac study single-lab with novel method
    • Which deacetylase-independent activities matter in epidermis not defined
  21. 2021 High

    Established that NCOR1/SMRT together are essential for adult survival via a hepatic lipid/metabolic pathway distinct from HDAC3, and showed at enhancers SMRT/GPS2 antagonize eRNA-coupled H3K27 acetylation to restrain inflammatory genes.

    Evidence Inducible global double knockout mice with metabolic phenotyping; ChIP-seq, CRISPR, 4C-seq, and in vivo macrophage eRNA depletion

    PMID:33503407 PMID:34390859

    Open questions at the time
    • Identity of the survival-critical pathway not pinpointed
    • Direct enhancer targets driving lethality unknown
  22. 2022 High

    Demonstrated NCOR2 functions in immunity and cancer—restraining B-cell differentiation and genomic stability, and repressing IRF-1-dependent interferon/proapoptotic genes via HDAC3 to limit antitumor responses, identifying the NCOR2-HDAC3 interface as a therapeutic target.

    Evidence B-cell conditional knockout with WGS/ChIP-seq/ATAC-seq; patient-derived organoid screening, AAV NCOR2-HDAC3 competitor, and in vivo tumor models

    PMID:35618935 PMID:36316474

    Open questions at the time
    • NCOR2 vs NCOR1 specificity in B cells not fully separated
    • Clinical translatability of the competitor not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How phosphorylation, ubiquitylation, dimerization, and splicing collectively program promoter-specific corepressor dismissal versus retention, and how NCOR2-specific (vs NCOR1-redundant) functions are partitioned across tissues, remain unresolved.
  • No unified model linking SMRT post-translational state to gene-selective output
  • Paralog division of labor incompletely defined
  • Full-complex structure including HDAC3 unsolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 6 GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 2 GO:0042393 histone binding 1
Localization
GO:0000228 nuclear chromosome 3 GO:0005634 nucleus 3 GO:0005829 cytosol 3
Pathway
R-HSA-1430728 Metabolism 5 R-HSA-162582 Signal Transduction 4 R-HSA-4839726 Chromatin organization 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1266738 Developmental Biology 3 R-HSA-168256 Immune System 3
Partners
BCL6GPS2HDAC3HDAC4NCOR1STAT5TBL1TBLR1
Complex memberships
NCoR/SMRT corepressor complex (HDAC3-TBL1-TBLR1-GPS2)mSin3A/HDAC1 complex

Evidence

Reading pass · 44 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 SMRT/NCOR2 directly interacts with mSin3A, which in turn interacts with HDAC1, forming a multisubunit repressor complex that mediates transcriptional repression by nuclear receptors (thyroid hormone and retinoic acid receptors). Co-immunoprecipitation, protein interaction assays, functional reporter assays with HDAC inhibitors Cell High 9150137
2000 SMRT and N-CoR exist in large (~1.5–2 MDa) protein complexes in HeLa nuclear extracts containing HDAC3 and TBL1 (a WD-40 repeat protein); these complexes bind unliganded thyroid hormone receptors in vitro, and antibodies against HDAC3 or SMRT/N-CoR partially relieve TR/RXR-mediated repression in Xenopus oocytes. Conventional and immunoaffinity chromatography, co-immunoprecipitation, in vitro binding assay, antibody microinjection in Xenopus oocytes The EMBO journal High 10944117
2000 SMRT forms a core complex with HDAC3 and TBL1; TBL1 interacts with histone H3 and is bridged to HDAC3 through SMRT, and TBL1 can potentiate transcriptional repression by thyroid hormone receptor in vivo. Immunoaffinity purification of HeLa nuclear extract SMRT complex, co-immunoprecipitation, histone interaction assays, transcriptional reporter assays Genes & development High 10809664
2001 SMRT functions as an activating cofactor for HDAC3 via a deacetylase activating domain (DAD) that includes one of its two SANT motifs. Recombinant HDAC3 alone is enzymatically inactive; SMRT DAD is necessary and sufficient to reconstitute HDAC3 deacetylase activity using purified components. Mutations in the DAD that abolish HDAC3 interaction also eliminate HDAC activity and the major repression function of SMRT. In vitro reconstitution with purified components, HDAC activity assays, mutagenesis of DAD domain, stable complex isolation Molecular and cellular biology High 11509652
1997 SMRT contains two distinct receptor interaction domains that independently bind nuclear receptors, and two separate transcriptional repression domains. Both repression domains interact weakly with mSin3A, and SMRT overexpression represses transcription from natural promoters. Deletion analysis, mammalian two-hybrid, Far-Western, co-immunoprecipitation, transcriptional reporter assays Molecular endocrinology High 9415406
1996 SMRT is a ubiquitous nuclear protein that interacts with unliganded nuclear receptor heterodimers in mammalian cells; expression of the receptor-interacting domain of SMRT acts as an antirepressor, and splicing variants modulate thyroid hormone and retinoic acid signaling. Mammalian cell transfection, co-immunoprecipitation, transcriptional reporter assays Proceedings of the National Academy of Sciences of the United States of America Medium 8755515
1998 SMRT interacts with the BCL-6 POZ/BTB domain, and this interaction is necessary for BCL-6-mediated transcriptional repression; POZ domains from other repressors (PLZF, ZID, GAGA) also interact with SMRT/N-CoR in vitro; BCL-6 and N-CoR co-localize to punctate nuclear regions. Yeast two-hybrid, mammalian two-hybrid, GST pulldown, co-immunoprecipitation, immunofluorescence co-localization, transcriptional reporter assays Oncogene High 9824158
2003 Crystal structure (2.2 Å) of the BCL6 BTB homodimer bound to a 17-residue SMRT fragment: two SMRT peptides bind symmetrically to the BCL6 BTB homodimer, revealing the structural basis of SMRT recruitment for transcriptional repression. X-ray crystallography, biochemical binding assays, in vivo functional assays Molecular cell High 14690607
2000 SMRT function is inhibited by a MAPK kinase kinase cascade downstream of EGF receptor: SMRT is phosphorylated by MEKK-1 and MEK-1, which inhibits its ability to tether to transcription factor partners and causes redistribution from nucleus to a perinuclear/cytoplasmic compartment. Kinase assays, transfection with constitutively active kinase constructs, subcellular fractionation, co-immunoprecipitation, transcriptional reporter assays Molecular and cellular biology High 10938135
2004 IKKα phosphorylates SMRT on chromatin, triggering nuclear export of SMRT and loss of chromatin-associated HDAC3, which is prerequisite for NF-κB-dependent transcription of cIAP-2 and IL-8; a nonphosphorylatable SMRT mutant blocks NF-κB recruitment and sensitizes cells to apoptosis. Chromatin immunoprecipitation (ChIP), nonphosphorylatable SMRT mutant expression, nuclear export assays, transcriptional reporter assays Molecular cell High 15494311
2006 IKKα phosphorylates both SMRT(S2410) and RelA/p65(S536) on chromatin; phospho-SMRT remains bound to NF-κB heterodimer but loses HDAC3 association, enabling p300-mediated acetylation of RelA/p65 at K310; nonphosphorylatable SMRT or RelA mutants maintain active SMRT-HDAC3 repression. ChIP, re-ChIP, nonphosphorylatable mutant expression, transcriptional reporter assays Molecular and cellular biology High 16382138
2001 SMRTe (full-length SMRT) inhibits MEF2C transcriptional activation by translocating HDAC4 from the cytoplasm to discrete nuclear domains and recruiting HDAC5 into these domains; SMRTe synergizes with HDAC4 and HDAC5 to inhibit MEF2C-dependent muscle differentiation gene expression. Indirect immunofluorescence, co-immunoprecipitation, nuclear fractionation, transcriptional reporter assays The Journal of biological chemistry Medium 11304536
2001 SMRT binds to the N-terminal coiled-coil domain of STAT5A and STAT5B, strongly represses STAT5-dependent transcription; a hyperactivating mutation in the STAT5 coiled-coil domain that renders it constitutively active abolishes SMRT interaction; SMRT overexpression suppresses IL-3-induced STAT5 target gene expression. Yeast two-hybrid, co-immunoprecipitation, transcriptional reporter assays, overexpression in cell lines The EMBO journal Medium 11726519
2002 SMRT directly interacts with the androgen receptor (AR) ligand-binding domain; the SMRT C-terminal ID2 region mediates interaction; SMRT overexpression inhibits DHT-dependent AR transactivation by inhibiting AR N/C interaction and competing with p160 coactivators; a mutation in the SMRT ID2 corepressor motif abolishes interaction. GST pulldown, mammalian two-hybrid, transcriptional reporter assays, co-immunoprecipitation The Journal of biological chemistry Medium 12441355
2004 SMRT and N-CoR are regulated by distinct kinase signaling pathways: MEKK1 activation leads to SMRT phosphorylation, dissociation from transcription factor partners in vivo and in vitro, and nuclear-to-cytoplasmic redistribution; N-CoR is refractory to all these MAPK cascade effects. Co-immunoprecipitation, in vitro binding assays, subcellular fractionation, kinase assays The Journal of biological chemistry Medium 15491994
2001 SMRT is phosphorylated in vivo and in vitro at a CK2 motif centered on serine 1492 within the nuclear receptor interaction domain; CK2-mediated phosphorylation stabilizes SMRT interaction with nuclear hormone receptors. In vitro phosphorylation assays, mutagenesis, co-immunoprecipitation Molecular and cellular biochemistry Medium 11451368
2004 SMRT binds to the C/EBPβ TAD domain and Nrf2 Neh4/5 domain; glucocorticoid-activated GR recruits SMRT to the GSTA2 promoter to repress C/EBPβ- and Nrf2-mediated GSTA2 induction; siRNA knockdown of SMRT abolishes repression. Co-immunoprecipitation, ChIP, GST pulldown, siRNA knockdown, transcriptional reporter assays Molecular and cellular biology High 15870285
2008 TBL1 and TBLR1 phosphorylation at the promoter level (e.g., by PKCδ for TBLR1) triggers ubiquitylation and degradation of NCoR/SMRT, enabling corepressor dismissal as a prerequisite for gene activation across multiple signaling pathways (Notch, NF-κB, nuclear receptor ligands). ChIP, co-immunoprecipitation, ubiquitylation assays, siRNA knockdown, kinase assays Molecular cell High 18374649
2011 Crystal structure of the tetrameric oligomerization domain of TBL1 reveals how it interacts with both SMRT and GPS2; NMR structure of the GPS2-SMRT interface defines assembly mechanism and stoichiometry of the core repression complex. Mutagenesis and functional assays validate the structural model. X-ray crystallography, NMR spectroscopy, computational docking, mutagenesis, functional assays Nature structural & molecular biology High 21240272
2005 SMRT interacts with PXR through PXR's ligand-binding domain and SMRT's nuclear receptor-interacting domain 2; the PXR-SMRT interaction is disrupted by PXR ligands (Rif, CTZ), causing exchange of SMRT for the p160 coactivator RAC3; deletion of AF-2 helix enhances SMRT binding; SMRT overexpression inhibits PXR transactivation of CYP3A4 and siRNA depletion enhances it. GST pulldown, yeast two-hybrid, mammalian two-hybrid, co-localization, siRNA knockdown, transcriptional reporter assays Molecular pharmacology Medium 16219912
2008 Cdk2 phosphorylates SMRT at multiple sites required for interaction with the peptidyl-prolyl isomerase Pin1; Pin1 interaction decreases SMRT protein stability and reduces SMRT-dependent transcriptional repression; Her2/Neu/ErbB2 receptor activation leads to SMRT destabilization via this Cdk2-Pin1 cascade. Co-immunoprecipitation, in vitro binding assays, mutagenesis, protein stability assays, transcriptional reporter assays The Journal of cell biology Medium 18838553
2008 SMRT repression of nuclear receptors via its receptor interaction domain (RID) controls the adipogenic set point; SMRT(mRID) knock-in mice disrupting NHR interaction develop widespread metabolic defects including increased adiposity (70%), reduced respiration, and altered insulin sensitivity; MEFs from SMRT(mRID) mice display dramatically increased adipogenic capacity. Knock-in mouse model (RID mutation), metabolic phenotyping, MEF differentiation assays Proceedings of the National Academy of Sciences of the United States of America High 19066220
2010 SMRT expression and its occupancy on PPAR target gene promoters increase with age; selective disabling of SMRT's RID1 (SMRT(mRID1)) shifts repression to RID2-associated receptors (notably PPARs), causing premature aging-related metabolic diseases with reduced mitochondrial function; SMRT(mRID1) cells show increased susceptibility to oxidative damage rescued by PPAR activation or antioxidant treatment. Knock-in mouse model, ChIP, metabolic and mitochondrial function assays, antioxidant rescue experiments Cell metabolism High 21109196
2012 SMRT is required for full agonist-dependent ERα transcriptional activation; SMRT is recruited (along with ERα and SRC-3) to estrogen-responsive promoters in MCF-7 cells; SMRT depletion (but not HDAC1 or HDAC3 depletion) reduces estradiol-stimulated ERα activity and attenuates estrogen-dependent MCF-7 cell proliferation in a cell-type-specific manner. ChIP, siRNA knockdown, transcriptional reporter assays, cell proliferation assays Molecular and cellular biology Medium 17591692
2004 In frog development, unliganded thyroid hormone receptor recruits N-CoR/SMRT-TBLR1 complexes to chromatinized TR target promoters in vivo, accompanied by histone deacetylation and gene repression; T3 treatment dissociates these complexes and activates gene expression during metamorphosis. Frog oocyte chromatin injection, ChIP assays during spontaneous and T3-induced metamorphosis, dominant-negative constructs Molecular and cellular biology High 15060155
2016 NCOR1 and NCOR2 redundantly mediate RA-dependent repression of Fgf8 during somitogenesis; Ncor1;Ncor2 double mutants generated by CRISPR/Cas9 exhibit increased Fgf8 expression and FGF signaling; embryo ChIP reveals NCOR1/2 (but not coactivators) are recruited to the Fgf8 RARE in RA-dependent manner, whereas coactivators (not NCOR1/2) are recruited to an activated RARE near Rarb. CRISPR/Cas9 double knockout, embryo ChIP, CRISPR deletion of Fgf8 RARE, phenotypic analysis Developmental biology High 27506116
2014 In zebrafish, ncor2 is required for hematopoietic stem cell emergence in the AGM region; ncor2 knockdown upregulates fos transcription by increasing histone acetylation at the fos promoter, enhancing Vegfd signaling, which promotes Notch-dependent arterial endothelial fate and suppresses hemogenic endothelial specification. Zebrafish morpholino knockdown, ChIP (histone acetylation), epistasis experiments with Vegfd and Notch pathway inhibitors/activators Blood Medium 25006126
2019 NCOR1 and NCOR2 loss specifically in GABAergic neurons reduces GABRA2 expression in lateral hypothalamus GABAergic neurons, causing neuron hyperexcitability and impaired hippocampal LTP through a monosynaptic LH-GABAergic to CA3-GABAergic projection; optogenetic activation of this projection causes memory deficits, and targeted manipulation of LH or CA3 neuron activity reverses memory deficits. Cell-type-specific conditional knockout, optogenetics, electrophysiology (LTP), Western blot, behavioral assays Nature neuroscience High 30664766
2012 Wnt5a-induced CaMKII directly phosphorylates SMRT at Ser-1407, triggering translocation of SMRT from nucleus to cytoplasm and proteasomal degradation; this destabilizes SMRT and derepresses Notch1 signaling by enhancing Notch1-IC/RBP-Jk association and suppressing RBP-Jk/SMRT association. Kinase assay, phospho-site mutagenesis, co-immunoprecipitation, subcellular fractionation, proteasome inhibitor experiments, transcriptional reporter assays The Journal of biological chemistry Medium 22888005
2010 SMRT forms a protein homodimer; Erk2 phosphorylation disrupts SMRT self-dimerization in vitro and in vivo, resulting in a reorganized corepressor complex with reduced sedimentation coefficient, partial release of HDAC3, TBL-1, and TBLR-1, and inhibition of transcriptional repression. Co-immunoprecipitation, sedimentation analysis (sucrose gradient), in vitro binding and kinase assays, transcriptional reporter assays Molecular and cellular endocrinology Medium 20965228
2016 All components of the NCoR/SMRT corepressor complex (HDAC3, GPS2, NCoR, SMRT, TBL1, TBLR1) interact with HPV E8^E2C protein in an E8-domain-dependent manner; this interaction is required for E8^E2C-mediated inhibition of both viral transcription and HPV origin replication; a dominant-negative NCoR fragment activates transcription and replication only from wild-type but not NCoR/SMRT-binding-deficient E8^E2C genomes. Proteomics (co-precipitation/mass spectrometry), co-immunoprecipitation, co-localization, siRNA knockdown, viral replication assays PLoS pathogens High 27064408
2014 NCoR1 is the principal mediator of thyroid hormone sensitivity in liver in vivo, while SMRT plays little independent role in TH signaling; however, combined deletion of both SMRT and NCoR1 in liver greatly accentuates hepatic lipid synthesis, indicating cooperative control of hepatic lipid content through regulation of multiple nuclear receptors including TR. Liver-specific conditional knockout mice (SMRT-only, NCoR1-only, double KO), global SMRT KO, metabolic and gene expression analysis Molecular and cellular biology High 25421714
2021 GPS2 and SMRT co-occupy candidate enhancers with coactivators CBP and MED1 but antagonistically repress eRNA transcription-coupled H3K27 acetylation; corepressor depletion or inflammatory signaling triggers enhancer activation via a similar mechanism; depletion of SMRT/GPS2 causes derepression of inflammatory genes (Ccl2) in macrophages. ChIP-seq, CRISPR genome editing, transcriptional interference, 4C-seq, cistrome analysis, siRNA knockdown, in vivo macrophage-selective eRNA depletion in ob/ob mice Molecular cell High 33503407
2018 Crystal structures of two SMRT repression domain 3 (SRD3c) GSI-containing peptides in complex with HDAC4 show that these peptides form β-hairpin structures blocking the catalytic entry site of HDAC4 at class IIa HDAC-specific residues; SMRT binding does not activate the cryptic deacetylase activity of HDAC4, and mutagenesis confirms critical residues (including Arg1369) for optimal binding to HDAC4 and HDAC5. X-ray crystallography, mutagenesis, binding/interaction assays Nucleic acids research High 30321390
2022 NCOR2 inhibits antitumor treatment by regulating HDAC3 to repress IRF-1-dependent gene expression and interferon signaling; reducing NCOR2 or impairing its interaction with HDAC3 (via adeno-associated viral NCOR2-HDAC3 competitor) enhances chemotherapy responsiveness and restores antitumor immunity by permitting transcription of IRF-1-regulated proapoptosis and inflammatory genes. Functional proteomic screening of patient-derived organoids, knockdown, AAV competitor construct, in vivo tumor models, gene expression assays Nature cancer High 35618935
2008 VDR-bound SMRT represses CYP24A1; vitamin D3 activates CYP24A1 by dissociating SMRT from VDR at the promoter; PXR 'locks' SMRT onto the CYP24A1 promoter by preventing ligand-dependent dissociation of SMRT from VDR, thereby attenuating vitamin D3 activation; this mechanism was confirmed in Pxr+/+ vs Pxr-/- mice. ChIP, co-immunoprecipitation, transcriptional reporter assays, Pxr knockout mouse model Molecular pharmacology Medium 18981260
2020 In type 2 diabetic hearts, loss of NCOR2 repression leads to PPARα-mediated upregulation of MCUb (mitochondrial calcium uniporter inhibitory subunit), limiting mitochondrial Ca2+ uptake and impairing glucose oxidation; identified using Cas9-based gene promoter pulldown coupled with mass spectrometry and confirmed by ChIP. dCas9-based promoter pulldown with mass spectrometry, ChIP assays, gene therapy with dominant-negative MCUb transgene, metabolic and cardiac function assays Diabetes Medium 33303689
2022 NCOR1/2 deletion in B cells limits B cell differentiation via impaired V(D)J recombination, attenuates pre-BCR signaling, enhances STAT5-dependent transcription, causes derepression of EZH2-repressed gene modules including p53 pathway, and leads to aberrant Rag1/Rag2 expression with increased structural variants bearing cryptic recombination signal sequences. B cell-specific conditional knockout, whole-genome sequencing, ChIP-seq/ATAC-seq, gene expression analysis, flow cytometry Nature immunology High 36316474
1999 The TEL/ETV6 leukemia-associated transcription repressor's central region (maintained in t(12;21)) recruits a repression complex containing SMRT and mSin3A to mediate transcriptional repression, while its HLH domain represses via a SMRT/Sin3A-independent mechanism. Co-immunoprecipitation, transcriptional reporter assays, deletion analysis Biochemical and biophysical research communications Medium 10544023
2005 AhR activation by TCDD causes physical interaction between AhR and SMRT (corepressor of RARα), sequestering SMRT into nuclear bodies and activating RARα signaling in a ligand-independent manner; AhR and SMRT co-localize in nuclear bodies during this sequestration. Co-immunoprecipitation, immunocytochemistry, transcriptional reporter assays, TSA inhibitor experiments Biochimie Low 16480812
2008 VDR specifically interacts with SMRT interaction domain 1 (ID1) rather than ID2; specific residues within and outside the extended helix motif of SMRT-ID1 are required for VDR binding; SMRT mutants defective in VDR interaction fail to repress endogenous VDR target genes (osteocalcin, CYP24A1) in vivo. One- plus two-hybrid genetic selection, siRNA knockdown, ChIP, mutagenesis, transcriptional reporter assays Molecular endocrinology Medium 19098224
2009 Alternative splicing of SMRT generates isoforms with 1, 2, or 3 CoRNR box motifs; all six isoforms are expressed in human cell lines; the full complement of CoRNR boxes rather than individual box identity determines interaction affinity with nuclear receptors; 1-box isoform discriminates between DNA response elements, 2-box isoforms prefer TR complexes, and 3-box isoforms show differential receptor binding. RT-PCR (isoform detection), in vitro binding affinity measurements with nuclear receptor-DNA complexes Bioscience reports Medium 18752469
2021 Combined global postnatal deletion of NCOR1 and SMRT in adult mice is lethal within ten days; double knockout mice rapidly develop hypoglycemia, hypothermia, and hepatosteatosis with alterations in lipogenesis and beta-oxidation; this phenotype is distinct from HDAC3 knockout mice, implying NCOR1/SMRT together regulate a critical pathway required for adult survival that is separate from HDAC3. Tamoxifen-inducible conditional double knockout mouse model (UBC-Cre-ERT2), metabolic phenotyping, hepatic gene expression analysis Molecular metabolism High 34390859
2020 HDAC3 protein stability in epidermal cells depends on NCoR and SMRT functioning redundantly; however, point mutations in the NCoR and SMRT deacetylase-activating domains (DAD), which abolish HDAC3's enzymatic function, still permit normal epidermal stratification, indicating HDAC3's roles in this context are largely independent of its histone deacetylase activity. Conditional knockout of NCoR/SMRT in epidermis, DAD point-mutation knock-in mice, ChIP-seq, phenotypic analysis Genes & development High 32467224

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1997 Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 1096 9150137
1998 Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. Proceedings of the National Academy of Sciences of the United States of America 539 9501191
2000 Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. The EMBO journal 534 10944117
2001 The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Molecular and cellular biology 518 11509652
2018 Single molecule real-time (SMRT) sequencing comes of age: applications and utilities for medical diagnostics. Nucleic acids research 475 29401301
2000 A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes & development 390 10809664
1998 The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT. Oncogene 268 9824158
2003 Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Molecular cell 238 14690607
2013 Emerging roles of the corepressors NCoR1 and SMRT in homeostasis. Genes & development 230 23630073
1996 SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers. Proceedings of the National Academy of Sciences of the United States of America 213 8755515
2004 SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival. Molecular cell 185 15494311
2006 IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. Molecular and cellular biology 160 16382138
2016 Sequencing 16S rRNA gene fragments using the PacBio SMRT DNA sequencing system. PeerJ 157 27069806
2000 The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export. Molecular and cellular biology 156 10938135
2002 Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT. The Journal of biological chemistry 143 12441355
1999 Unique forms of human and mouse nuclear receptor corepressor SMRT. Proceedings of the National Academy of Sciences of the United States of America 137 10077563
2008 TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. Molecular cell 136 18374649
2011 Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. Nature structural & molecular biology 134 21240272
1999 The leukemia-associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A. Biochemical and biophysical research communications 125 10544023
2005 Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Molecular and cellular biology 124 15870285
2017 Global identification of alternative splicing via comparative analysis of SMRT- and Illumina-based RNA-seq in strawberry. The Plant journal : for cell and molecular biology 119 27997733
2017 Advantages of genome sequencing by long-read sequencer using SMRT technology in medical area. Human cell 110 28364362
2004 Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells. Oncogene 107 15300237
1999 SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor. Proceedings of the National Academy of Sciences of the United States of America 104 10097068
1997 Characterization of receptor interaction and transcriptional repression by the corepressor SMRT. Molecular endocrinology (Baltimore, Md.) 104 9415406
2004 Recruitment of N-CoR/SMRT-TBLR1 corepressor complex by unliganded thyroid hormone receptor for gene repression during frog development. Molecular and cellular biology 103 15060155
2014 Quantifying genome-editing outcomes at endogenous loci with SMRT sequencing. Cell reports 99 24685129
2001 Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription. The EMBO journal 94 11726519
2008 SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proceedings of the National Academy of Sciences of the United States of America 81 19066220
2018 SMRT-Cappable-seq reveals complex operon variants in bacteria. Nature communications 80 30201986
2008 T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain. The Biochemical journal 73 17990982
2007 The silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor is required for full estrogen receptor alpha transcriptional activity. Molecular and cellular biology 72 17591692
2004 SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways. The Journal of biological chemistry 70 15491994
2012 SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation. The Journal of clinical investigation 68 23221346
2019 LncRNA MIR22HG inhibits growth, migration and invasion through regulating the miR-10a-5p/NCOR2 axis in hepatocellular carcinoma cells. Cancer science 67 30680848
2018 HP1γ Promotes Lung Adenocarcinoma by Downregulating the Transcription-Repressive Regulators NCOR2 and ZBTB7A. Cancer research 67 29764865
2007 Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors. Cancer research 67 17804755
2019 Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Nature neuroscience 59 30664766
2018 Transcriptome profiling using Illumina- and SMRT-based RNA-seq of hot pepper for in-depth understanding of genes involved in CMV infection. Gene 57 29730427
2005 Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). Molecular pharmacology 56 16219912
2001 SMRTE inhibits MEF2C transcriptional activation by targeting HDAC4 and 5 to nuclear domains. The Journal of biological chemistry 56 11304536
2015 Quantitative and multiplexed DNA methylation analysis using long-read single-molecule real-time bisulfite sequencing (SMRT-BS). BMC genomics 55 25943404
2009 Loss of the SMRT/NCoR2 corepressor correlates with JAG2 overexpression in multiple myeloma. Cancer research 55 19417136
2008 Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT. The Journal of cell biology 53 18838553
2021 Recurrent novel HMGA2-NCOR2 fusions characterize a subset of keratin-positive giant cell-rich soft tissue tumors. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 51 33742141
2018 Genome re-annotation of the wild strawberry Fragaria vesca using extensive Illumina- and SMRT-based RNA-seq datasets. DNA research : an international journal for rapid publication of reports on genes and genomes 51 29036429
2013 Detecting DNA modifications from SMRT sequencing data by modeling sequence context dependence of polymerase kinetic. PLoS computational biology 50 23516341
2013 microRNA-100 targets SMRT/NCOR2, reduces proliferation, and improves survival in glioblastoma animal models. PloS one 50 24244722
2012 miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene. PloS one 50 22292036
2005 A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation. Journal of immunology (Baltimore, Md. : 1950) 50 15843525
2014 NCoR1 and SMRT play unique roles in thyroid hormone action in vivo. Molecular and cellular biology 45 25421714
2010 Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration. Cell metabolism 45 21109196
1999 Expression of nuclear receptor interacting proteins TIF-1, SUG-1, receptor interacting protein 140, and corepressor SMRT in tamoxifen-resistant breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 45 10589759
2016 Interaction of NCOR/SMRT Repressor Complexes with Papillomavirus E8^E2C Proteins Inhibits Viral Replication. PLoS pathogens 44 27064408
2016 Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis. Developmental biology 44 27506116
2014 Ncor2 is required for hematopoietic stem cell emergence by inhibiting Fos signaling in zebrafish. Blood 44 25006126
2004 Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300. Biochemical and biophysical research communications 44 14985122
2012 Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes. The Journal of steroid biochemistry and molecular biology 43 22944139
2017 SMRT Sequencing Revealed Mitogenome Characteristics and Mitogenome-Wide DNA Modification Pattern in Ophiocordyceps sinensis. Frontiers in microbiology 42 28798740
2001 The SMRT corepressor is a target of phosphorylation by protein kinase CK2 (casein kinase II). Molecular and cellular biochemistry 42 11451368
2021 The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages. Molecular cell 41 33503407
2005 The aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism. Biochimie 39 16480812
2022 Screening of organoids derived from patients with breast cancer implicates the repressor NCOR2 in cytotoxic stress response and antitumor immunity. Nature cancer 38 35618935
2012 Wnt5a controls Notch1 signaling through CaMKII-mediated degradation of the SMRT corepressor protein. The Journal of biological chemistry 36 22888005
2011 SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization. Journal of cell science 36 22193958
2022 Xanthogranulomatous epithelial tumors and keratin-positive giant cell-rich soft tissue tumors: two aspects of a single entity with frequent HMGA2-NCOR2 fusions. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 35 35690644
2014 Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters. International journal of cancer 35 25363551
2009 CITED2 and NCOR2 in anti-oestrogen resistance and progression of breast cancer. British journal of cancer 35 19904269
2004 Retinoids repress Ah receptor CYP1A1 induction pathway through the SMRT corepressor. Biochemical and biophysical research communications 34 15325265
2020 Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function. Diabetes 33 33303689
2020 PPARα and NCOR/SMRT corepressor network in liver metabolic regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32 32396271
2008 Involvement of SMRT corepressor in transcriptional repression by the vitamin D receptor. Molecular endocrinology (Baltimore, Md.) 32 19098224
2022 Recurrent Fusion of the Genes for High-mobility Group AT-hook 2 (HMGA2) and Nuclear Receptor Co-repressor 2 (NCOR2) in Osteoclastic Giant Cell-rich Tumors of Bone. Cancer genomics & proteomics 31 35181586
2018 Structural basis of the specific interaction of SMRT corepressor with histone deacetylase 4. Nucleic acids research 31 30321390
2012 SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ERα transcriptional activity. Cancer research 31 23117886
2021 Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer. Cell reports 28 34910907
2020 HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity. Genes & development 28 32467224
2012 miR-125b Regulation of Androgen Receptor Signaling Via Modulation of the Receptor Complex Co-Repressor NCOR2. BioResearch open access 26 23514806
2023 Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases. Frontiers in molecular biosciences 25 37674539
2020 Integration analysis of PacBio SMRT- and Illumina RNA-seq reveals candidate genes and pathway involved in selenium metabolism in hyperaccumulator Cardamine violifolia. BMC plant biology 25 33109081
2015 SMRT sequencing of the Campylobacter coli BfR-CA-9557 genome sequence reveals unique methylation motifs. BMC genomics 25 26689587
2012 Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression. Biochemical and biophysical research communications 25 22695118
2008 Nuclear xenobiotic receptor pregnane X receptor locks corepressor silencing mediator for retinoid and thyroid hormone receptors (SMRT) onto the CYP24A1 promoter to attenuate vitamin D3 activation. Molecular pharmacology 25 18981260
2021 Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis. Molecular metabolism 24 34390859
2019 SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A (H7N9) virus infection. Emerging microbes & infections 24 31084471
2018 BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen-Resistant Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 24 29420220
2015 SMRT Sequencing for Parallel Analysis of Multiple Targets and Accurate SNP Phasing. G3 (Bethesda, Md.) 24 26497143
2015 Functional Variants in Notch Pathway Genes NCOR2, NCSTN, and MAML2 Predict Survival of Patients with Cutaneous Melanoma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 22 25953768
2015 Mutation assay using single-molecule real-time (SMRT(TM)) sequencing technology. Genes and environment : the official journal of the Japanese Environmental Mutagen Society 22 27350811
2010 Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation. Molecular and cellular endocrinology 22 20965228
2003 Distinct nuclear body components, PML and SMRT, regulate the trans-acting function of HTLV-1 Tax oncoprotein. Oncogene 22 12642864
2023 Giant Cell Tumors With HMGA2::NCOR2 Fusion : Clinicopathologic, Molecular, and Epigenetic Study of a Distinct Entity. The American journal of surgical pathology 21 37170907
2020 Circular RNA circ-NCOR2 accelerates papillary thyroid cancer progression by sponging miR-516a-5p to upregulate metastasis-associated protein 2 expression. The Journal of international medical research 20 32940102
2007 The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells. Virology 20 17643463
2005 Alteration of SMRT tumor suppressor function in transformed non-Hodgkin lymphomas. Cancer research 19 15930272
2018 Characterizing the DNA Methyltransferases of Haloferax volcanii via Bioinformatics, Gene Deletion, and SMRT Sequencing. Genes 17 29495512
2009 Alternative splicing determines the interaction of SMRT isoforms with nuclear receptor-DNA complexes. Bioscience reports 17 18752469
2016 Association of Forced Vital Capacity with the Developmental Gene NCOR2. PloS one 16 26836265
2016 Inhibition effect of cypermethrin mediated by co-regulators SRC-1 and SMRT in interleukin-6-induced androgen receptor activation. Chemosphere 16 27239967
2022 Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation. Nature immunology 15 36316474

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