Affinage

Showing KDM5D — SMCY is a alias.

KDM5D

Lysine-specific demethylase 5D · UniProt Q9BY66

Length
1539 aa
Mass
174.1 kDa
Annotated
2026-06-10
100 papers in source corpus 14 papers cited in narrative 14 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KDM5D (SMCY/JARID1D) is a Y-chromosome-encoded histone H3K4 demethylase that shapes transcriptional programs governing cell-cycle progression, genome stability, and tumor invasiveness (PMID:29863497, PMID:37344599). Through removal of activating H3K4me3 marks at target promoters, it represses gene programs including E2F1 (and its downstream effector FKBP4), CUL4A, Mars2, and regulators of epithelial tight junctions and MHC class I (PMID:30864186, PMID:34688635, PMID:34273914, PMID:37344599); loss of KDM5D accelerates cell-cycle progression and mitotic entry, increases DNA-replication stress with ATR activation, and promotes epithelial-mesenchymal transition and invasiveness, whereas its activity suppresses these phenotypes (PMID:29863497, PMID:30864186, PMID:37344599). KDM5D was originally identified as the source of male-specific H-Y minor histocompatibility antigen peptides presented by MHC, distinguishing it from its X-homologue (PMID:7667640, PMID:7544442). Beyond chromatin, KDM5D acts as a protein-lysine demethylase: it binds p38α (MAPK14) and demethylates it at K165 to suppress p38α phosphorylation and activity (PMID:39636854), and it physically associates with the androgen receptor in the nucleus to modulate AR transcriptional output, with its loss conferring docetaxel resistance in prostate cancer (PMID:27185910). In germ cells, KDM5D forms a complex with the meiotic regulator MSH5 during spermatogenesis (PMID:18459961). It cooperates with its X-paralog KDM5C in heart development (PMID:31560558, PMID:32081420). Pharmacologically, its activity is regulated upstream by miR-4661-5p and by KRAS*/STAT4 signaling (PMID:34273914, PMID:37344599).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1995 High

    Established KDM5D/SMCY as the molecular source of the male-specific H-Y minor histocompatibility antigen, explaining sex-mismatched transplant rejection at the level of a defined peptide epitope.

    Evidence Peptide elution from HLA molecules with mass spectrometry and T-cell cytotoxicity assays, in human (HLA-B7) and mouse (Kk) systems

    PMID:7544442 PMID:7667640

    Open questions at the time
    • Did not address the enzymatic or chromatin function of the protein
    • Antigen presentation does not establish a cellular role for KDM5D
  2. 2008 Medium

    Showed that the SMCY protein possesses intrinsic histone H3K4 demethylase activity and physically partners with the meiotic regulator MSH5 in germ cells, assigning it a chromatin-modifying enzyme function and a spermatogenesis-specific complex.

    Evidence Reciprocal Co-IP, in vitro histone demethylase assay, and immunohistochemical co-localization during murine meiotic prophase

    PMID:18459961

    Open questions at the time
    • Functional consequence of the MSH5 complex in meiosis not defined
    • Genome-wide demethylase targets not mapped
    • Single-lab finding
  3. 2016 High

    Connected KDM5D demethylase activity to androgen receptor signaling, linking its loss to therapy resistance in prostate cancer.

    Evidence Nuclear-fraction Co-IP, ChIP for H3K4me3 at AR targets, RNA-seq, siRNA knockdown, and docetaxel viability assays in prostate cancer cells

    PMID:27185910

    Open questions at the time
    • Direct AR-binding interface not mapped
    • Whether AR regulation requires catalytic activity not isolated
  4. 2018 High

    Defined KDM5D as a genome-wide guardian of cell-cycle and replication control, showing its loss creates ATR-dependent replication stress that can be exploited therapeutically.

    Evidence ChIP-seq mapping to cell-cycle TF-motif promoters, loss-of-function knockdown, ATR inhibitor treatment, and apoptosis assays in prostate cancer cells

    PMID:29863497

    Open questions at the time
    • Specific direct target genes mediating the replication-stress phenotype not individually validated
    • Catalytic dependence of phenotype not formally separated
  5. 2019 Medium

    Extended KDM5D function to suppression of EMT and invasion via promoter-specific H3K4me3 demethylation of CUL4A in gastric cancer.

    Evidence ChIP-qPCR at CUL4A promoter, siRNA knockdown, transwell migration/invasion assays, and xenografts

    PMID:30864186

    Open questions at the time
    • Downstream ZEB1/p21/p53 effects correlative
    • Single-lab finding
  6. 2019 Medium

    Implicated KDM5D, cooperatively with its X-paralog KDM5C, in cardiac differentiation and cell-cycle control during development.

    Evidence siRNA knockdown in cardiomyocyte differentiation models with cell-cycle analysis and cardiac marker profiling (2019); compound Kdm5c/Kdm5d mouse knockouts with cardiac histology (2020)

    PMID:31560558 PMID:32081420

    Open questions at the time
    • Molecular targets in cardiac tissue not identified
    • Degree of paralog redundancy versus distinct function not fully resolved
  7. 2021 Medium

    Mapped specific KDM5D-controlled oncogenic transcriptional axes, defining a KDM5D→E2F1→FKBP4 cascade and direct repression of Mars2, the latter relieved by miR-4661-5p.

    Evidence ChIP-qPCR at E2F1 and Mars2 promoters, luciferase reporters, miRNA over/under-expression, and rescue experiments in colorectal and gastric cancer cells

    PMID:34273914 PMID:34688635

    Open questions at the time
    • Individual axes characterized in single cancer models
    • Whether axes operate concurrently in the same cells not tested
  8. 2023 High

    Placed KDM5D downstream of KRAS*/STAT4 signaling as an immune-evasion and invasion driver that represses tight-junction and MHC-I genes, with gain- and loss-of-function reversing CD8+ T-cell killing and invasiveness.

    Evidence Transgenic and conditional Kdm5d mouse models, transcriptomic/chromatin analysis, CD8+ T-cell killing assays, and in vivo invasion assays in colorectal cancer

    PMID:37344599

    Open questions at the time
    • Direct chromatin occupancy at each repressed locus not individually resolved
    • Generalizability beyond KRAS-mutant context unknown
  9. 2023 Medium

    Identified a context-dependent role in which KDM5D upregulation promotes platinum tolerance through AURKB regulation in head and neck cancer, contrasting with its tumor-suppressive roles elsewhere.

    Evidence Knockdown, RT-qPCR for AURKB, cell-cycle analysis, AURKB inhibition, and in vivo drug-tolerance assays

    PMID:36982384

    Open questions at the time
    • Mechanism of AURKB mRNA regulation (direct vs indirect) not resolved
    • Single-lab finding
  10. 2024 High

    Demonstrated that KDM5D is a protein-lysine demethylase acting beyond chromatin, demethylating p38α at K165 to suppress its phosphorylation and pro-tumor activity.

    Evidence Co-IP, in vitro demethylation assay with K165 site-directed mutagenesis, phosphorylation readouts, and lung cancer xenografts

    PMID:39636854

    Open questions at the time
    • Breadth of non-histone substrate repertoire unknown
    • Relative contribution of histone vs protein substrate demethylation to phenotypes not quantified
  11. 2024 Low

    Tested pharmacological enhancement of KDM5D, with curcumin increasing its expression and activity to suppress AR/EMT signaling in castration-resistant prostate cancer.

    Evidence Curcumin-induced KDM5D activation, demethylase activity assay, invasion assay, and AR/EMT marker analysis

    PMID:39218854

    Open questions at the time
    • Effect inferred from correlative activity/expression changes without catalytic-site mutagenesis
    • Off-target effects of curcumin not excluded

Open questions

Synthesis pass · forward-looking unresolved questions
  • The full substrate spectrum of KDM5D as a dual histone- and protein-lysine demethylase, and what determines its opposing tumor-suppressive versus pro-tolerance roles across tissues, remain unresolved.
  • No structural model of KDM5D substrate recognition
  • Context determinants of tumor-suppressor vs oncogenic behavior undefined
  • Genome-wide direct-target catalogue incomplete

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140098 catalytic activity, acting on RNA 3 GO:0140110 transcription regulator activity 3 GO:0016491 oxidoreductase activity 2 GO:0140096 catalytic activity, acting on a protein 1
Localization
GO:0005634 nucleus 1 GO:0005829 cytosol 1
Pathway
R-HSA-4839726 Chromatin organization 4 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1640170 Cell Cycle 2 R-HSA-162582 Signal Transduction 1
Partners
ARMAPK14MSH5

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 KDM5D (SMCY) encodes an 11-residue peptide epitope that is presented by HLA-B7 as a human H-Y minor histocompatibility antigen; the homologous X-chromosome protein SMCX differs by two amino acid residues in the same region, explaining male specificity. Peptide elution from HLA molecules, mass spectrometry, T-cell cytotoxicity assay Science High 7667640
1995 The mouse Smcy gene encodes the H-Y Kk epitope defined by the octamer peptide TENSGKDI; no equivalent peptide is found in the X-homologue Smcx, establishing Smcy (KDM5D ortholog) as a source of male-specific transplantation antigen peptides. Peptide identification, T-cell cytotoxicity assay, gene mapping Nature High 7544442
2008 SMCY (KDM5D) forms a distinct protein complex with MSH5 (a meiosis-regulatory protein) in human testicular germ cells (NEC8 line), co-localizes with MSH5 at a specific stage of meiotic prophase during murine spermatogenesis, and displays histone H3K4 demethylase activity in biochemical assays. Co-immunoprecipitation/biochemical protein identification, histone demethylase activity assay, immunohistochemistry, co-localization Genes to cells Medium 18459961
2016 KDM5D physically interacts with the androgen receptor (AR) in the nucleus and regulates AR transcriptional activity by demethylating H3K4me3 marks; knockdown of KDM5D dysregulates AR signaling and confers docetaxel resistance in prostate cancer cells in the presence of dihydrotestosterone. Co-immunoprecipitation (nuclear fraction), RNA-seq, ChIP, siRNA knockdown, cell viability assay PNAS High 27185910
2018 KDM5D preferentially binds to promoter regions enriched for cell-cycle transcription factor motifs (by ChIP-seq); loss of KDM5D leads to dysregulated H3K4me3 marks, accelerated cell cycle progression and mitotic entry, increased DNA-replication stress, and activation of ATR kinase; ATR inhibition in KDM5D-deficient prostate cancer cells enhances DNA damage and induces apoptosis. ChIP-seq, FISH (Y chromosome deletion), siRNA/shRNA knockdown, ATR inhibitor treatment, apoptosis assay Journal of Clinical Investigation High 29863497
2019 KDM5D demethylates H3K4me3 at the promoter of CUL4A, reducing CUL4A expression, which leads to decreased ZEB1 and altered p21/p53 levels; knockdown of KDM5D in gastric cancer cells increases cell migration, invasion, and tumor formation in vivo, while overexpression suppresses epithelial-mesenchymal transition. ChIP-qPCR (H3K4me3 at CUL4A promoter), siRNA knockdown, transwell migration/invasion assay, in vivo xenograft Journal of Cellular Biochemistry Medium 30864186
2019 KDM5D knockdown via siRNA in cardiomyocyte differentiation models causes accumulation of cells in S-phase, impaired progression to cardiomyocytes, absence of spontaneous beating, and altered cardiac progenitor marker expression; KDM5D is upregulated during cardiac mesoderm stage of development and acts cooperatively with its X-homologue KDM5C. siRNA knockdown, cell cycle analysis (S-phase accumulation), expression profiling of cardiac progenitor markers, beating cell assay Journal of Proteome Research Medium 31560558
2020 Combined genetic deletion of Kdm5c and Kdm5d (but not either alone) in mice results in noncompaction cardiomyopathy with prominent trabecular extension and thin compacted myocardium, demonstrating that Kdm5d and Kdm5c have conserved and partially redundant roles in heart development. Genetic mouse knockouts (compound hemizygous and homozygous), histological examination of cardiac phenotype Biochemical and Biophysical Research Communications Medium 32081420
2021 KDM5D suppresses E2F1 expression by mediating H3K4me3 demethylation at the E2F1 locus; reduced E2F1 in turn decreases transcription of FKBP4 (confirmed by ChIP-qPCR and luciferase reporter assays); overexpression of FKBP4 rescues the anti-tumor effect of KDM5D in colorectal cancer cells. ChIP-qPCR (H3K4me3 at E2F1 promoter), luciferase reporter assay, overexpression/rescue experiments, in vitro and in vivo growth/metastasis assays Biochemical Pharmacology Medium 34688635
2021 miR-4661-5p targets KDM5D mRNA and downregulates KDM5D expression, leading to increased H3K4me3 at the Mars2 promoter and elevated Mars2 transcription, which promotes gastric cancer cell proliferation, migration, and invasion; direct KDM5D occupancy at the Mars2 promoter was demonstrated by ChIP. miRNA overexpression/inhibition, ChIP (H3K4me3 at Mars2 promoter), siRNA KDM5D knockdown, cell functional assays Cell Biology International Medium 34273914
2023 In colorectal cancer, KRAS*-mediated activation of the STAT4 transcription factor drives transcriptional upregulation of KDM5D; KDM5D-dependent H3K4 demethylation represses regulators of epithelial tight junctions and MHC class I components; Kdm5d deletion increases tight junction integrity, decreases cell invasiveness, and enhances CD8+ T-cell-mediated cancer cell killing, while Kdm5d transgenic expression increases tumor invasiveness in vivo. Transgenic/conditional knockout mouse models, transcriptomic and chromatin mark analysis (ChIP-seq inferred), CD8+ T-cell killing assay, in vivo tumor invasion assay, STAT4 pathway analysis Nature High 37344599
2024 KDM5D directly interacts with p38α (MAPK14) and demethylates p38α at lysine 165 (K165); K165 methylation promotes p38α phosphorylation and activation, while KDM5D-mediated demethylation inhibits p38α phosphorylation, thereby suppressing tumor cell proliferation and migration in non-small cell lung cancer xenograft models. Co-immunoprecipitation (KDM5D–p38α interaction), in vitro demethylation assay, site-directed mutagenesis (K165), phosphorylation assays, KDM5D knockdown/overexpression, xenograft tumor model PNAS High 39636854
2024 Curcumin enhances both the expression and demethylase activity of KDM5D (JARID1D), and increased KDM5D activity suppresses AR and EMT signaling cascades to inhibit invasion of castration-resistant prostate cancer cells. KDM5D overexpression/pharmacological activation by curcumin, demethylase activity assay, invasion assay, AR and EMT marker analysis Cancer Cell International Low 39218854
2023 KDM5D upregulation promotes platinum (cisplatin) tolerance in head and neck squamous cell carcinoma by modulating Aurora Kinase B (AURKB) mRNA levels; KDM5D knockdown reduces persister-cell tolerance to platinum agents, causes DNA damage checkpoint deregulation and abnormal mitosis; AURKB inhibition overcomes the tolerance, identifying a KDM5D/AURKB regulatory axis. KDM5D knockdown (siRNA/shRNA), RT-qPCR (AURKB mRNA), cell cycle analysis, in vitro and in vivo (xenograft) drug tolerance assays International Journal of Molecular Sciences Medium 36982384

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1995 Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein. Science (New York, N.Y.) 311 7667640
1977 Responsiveness to HY antigen Ir gene complementation and target cell specificity. Immunological reviews 245 70400
1983 Identification of the hypusine-containing protein hy+ as translation initiation factor eIF-4D. Proceedings of the National Academy of Sciences of the United States of America 209 6403941
1995 Identification of a mouse male-specific transplantation antigen, H-Y. Nature 163 7544442
2000 The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen. Journal of immunology (Baltimore, Md. : 1950) 149 10679124
2016 Resistance to docetaxel in prostate cancer is associated with androgen receptor activation and loss of KDM5D expression. Proceedings of the National Academy of Sciences of the United States of America 132 27185910
1991 Mutational analysis and characterization of the Escherichia coli hya operon, which encodes [NiFe] hydrogenase 1. Journal of bacteriology 118 1856178
1997 The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning. Annual review of immunology 117 9143681
2023 Histone demethylase KDM5D upregulation drives sex differences in colon cancer. Nature 107 37344599
1987 Separation of the genetic loci for the H-Y antigen and for testis determination on human Y chromosome. Nature 105 3494951
1980 Female phenotype and multiple abnormalities in sibs with a Y chromosome and partial X chromosome duplication: H--Y antigen and Xg blood group findings. Journal of medical genetics 85 7193738
1988 Location of the genes controlling H-Y antigen expression and testis determination on the mouse Y chromosome. Proceedings of the National Academy of Sciences of the United States of America 80 3261868
1993 Leucocyte endothelial cell adhesion: a study comparing human umbilical vein endothelial cells and the endothelial cell line EA-hy-926. Scandinavian journal of immunology 73 8356403
1994 Anaerobic regulation of the hydrogenase 1 (hya) operon of Escherichia coli. Journal of bacteriology 72 8071220
1988 Location of the targets of the hpr-97, sacU32(Hy), and sacQ36(Hy) mutations in upstream regions of the subtilisin promoter. Journal of bacteriology 72 2447063
2018 ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D. The Journal of clinical investigation 70 29863497
1990 A subset of hY RNAs is associated with erythrocyte Ro ribonucleoproteins. The EMBO journal 65 1698620
2015 Allogeneic HY antibodies detected 3 months after female-to-male HCT predict chronic GVHD and nonrelapse mortality in humans. Blood 61 25766725
1997 Effects of sigmaS and the transcriptional activator AppY on induction of the Escherichia coli hya and cbdAB-appA operons in response to carbon and phosphate starvation. Journal of bacteriology 60 9079897
1988 Molecular and cytogenetic evidence for the location of Tdy and Hya on the mouse Y chromosome short arm. Proceedings of the National Academy of Sciences of the United States of America 60 3413106
1977 H-Y antigen and the genetics of sex determination. Science (New York, N.Y.) 60 335511
2005 Effect of thalidomide affecting VEGF secretion, cell migration, adhesion and capillary tube formation of human endothelial EA.hy 926 cells. Life sciences 57 16310808
1994 Deletion mapping by immunoselection against the H-Y histocompatibility antigen further resolves the Sxra region of the mouse Y chromosome and reveals complexity of the Hya locus. Genomics 57 7896271
2008 DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells. Blood 56 18299450
2014 Clinical impact of H-Y alloimmunity. Immunologic research 55 24781195
2017 Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma. Scientific reports 53 28332632
2005 Retropseudogenes derived from the human Ro/SS-A autoantigen-associated hY RNAs. Nucleic acids research 53 15817567
2006 Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism. Biochimica et biophysica acta 49 16571380
1997 Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven. Mammalian genome : official journal of the International Mammalian Genome Society 49 9060413
2001 Examination of HY response: T cell expansion, immunodominance, and cross-priming revealed by HY tetramer analysis. Journal of immunology (Baltimore, Md. : 1950) 47 11564792
2008 Spermatogenesis-specific association of SMCY and MSH5. Genes to cells : devoted to molecular & cellular mechanisms 46 18459961
1989 Stability of the thrombin-thrombomodulin complex on the surface of endothelial cells from human saphenous vein or from the cell line EA.hy 926. The Biochemical journal 46 2541686
2011 Secondary recurrent miscarriage and H-Y immunity. Human reproduction update 44 21482560
1991 Endothelin-1 is expressed and released by a human endothelial hybrid cell line (EA.hy 926). Biochemical and biophysical research communications 44 1755833
2015 Tolerance induction using nanoparticles bearing HY peptides in bone marrow transplantation. Biomaterials 42 26513216
1999 Response of hya expression to external pH in Escherichia coli. Journal of bacteriology 42 10464194
2005 Expression of Integrins and Adhesive Properties of Human Endothelial Cell Line EA.hy 926. Cancer genomics & proteomics 41 31394624
1994 The human Y4 small cytoplasmic RNA gene is controlled by upstream elements and resides on chromosome 7 with all other hY scRNA genes. Nucleic acids research 39 7520568
2022 Effects of mixed Eimeria challenge on performance, body composition, intestinal health, and expression of nutrient transporter genes of Hy-Line W-36 pullets (0-6 wks of age). Poultry science 37 36130447
1981 Genetic aspects of H-Y antigen. Human genetics 37 7026414
2019 KDM5D inhibit epithelial-mesenchymal transition of gastric cancer through demethylation in the promoter of Cul4A in male. Journal of cellular biochemistry 35 30864186
1993 Regulation of CD59 expression on the human endothelial cell line EA.hy 926. European journal of immunology 35 7691609
1998 Rickettsia rickettsii infection of the EA.hy 926 endothelial cell line: morphological response to infection and evidence for oxidative injury. Microbiology (Reading, England) 31 9720025
1998 HA-1 and the SMCY-derived peptide FIDSYICQV (H-Y) are immunodominant minor histocompatibility antigens after bone marrow transplantation. Transplantation 31 9798702
2002 Nuclear localisation of cytosolic phospholipase A2-alpha in the EA.hy.926 human endothelial cell line is proliferation dependent and modulated by phosphorylation. Journal of cell science 30 12414998
1991 Variable spread of X inactivation affecting the expression of different epitopes of the Hya gene product in mouse B-cell clones. Immunogenetics 29 1995476
2021 KDM5D inhibits the transcriptional activation of FKBP4 by suppressing the expression of E2F1 in colorectal cancer in males. Biochemical pharmacology 28 34688635
2020 ETV4 promotes the progression of gastric cancer through regulating KDM5D. European review for medical and pharmacological sciences 27 32196595
2007 Dominant TEL1-hy mutations compensate for Mec1 lack of functions in the DNA damage response. Molecular and cellular biology 26 17954565
1997 Novel HY peptide antigens presented by HLA-B27. Journal of immunology (Baltimore, Md. : 1950) 26 9300696
2015 HY-Specific Induced Regulatory T Cells Display High Specificity and Efficacy in the Prevention of Acute Graft-versus-Host Disease. Journal of immunology (Baltimore, Md. : 1950) 25 26048147
2005 Cytosolic phospholipase A2-alpha and cyclooxygenase-2 localize to intracellular membranes of EA.hy.926 endothelial cells that are distinct from the endoplasmic reticulum and the Golgi apparatus. The FEBS journal 25 15720401
2001 Identification of a novel cis-acting RNA element involved in nuclear export of hY RNAs. RNA (New York, N.Y.) 25 11350038
1995 Evidence that the Gya, Hy and Joa antigens belong to the Dombrock blood group system. Vox sanguinis 25 7625075
2023 Comparative characterization of flavor precursors and volatiles of Taihe black-boned silky fowl and Hy-line Brown yolks using multiomics and GC-O-MS-based volatilomics. Food research international (Ottawa, Ont.) 24 37689921
2013 HY-1 induces G(2)/M cell cycle arrest in human colon cancer cells through the ATR-Chk1-Cdc25C and Weel pathways. Cancer science 24 23600770
1996 H-Y antigens. Human genetics 24 8641682
2009 Activator protein 1 shows a biphasic induction and transcriptional activity after low dose X-irradiation in EA.hy.926 endothelial cells. Autoimmunity 23 19811296
2005 Identification of the immunodominant HY H2-D(k) epitope and evaluation of the role of direct and indirect antigen presentation in HY responses. Journal of immunology (Baltimore, Md. : 1950) 23 16301625
2019 Down-Regulation of a Male-Specific H3K4 Demethylase, KDM5D, Impairs Cardiomyocyte Differentiation. Journal of proteome research 22 31560558
2018 Biodegradation of Lignin Monomers Vanillic, p-Coumaric, and Syringic Acid by the Bacterial Strain, Sphingobacterium sp. HY-H. Current microbiology 22 29750329
2015 Genetic and functional characterization of an extracellular modular GH6 endo-β-1,4-glucanase from an earthworm symbiont, Cellulosimicrobium funkei HY-13. Antonie van Leeuwenhoek 22 26481128
2015 Commercial Hy-Line W-36 pullet and laying hen venous blood gas and chemistry profiles utilizing the portable i-STAT®1 analyzer. Poultry science 22 26706355
2014 HY immune tolerance is common in women without male offspring. PloS one 22 24646895
1997 Effects of the sinR and degU32 (Hy) mutations on the regulation of the aprE gene in Bacillus subtilis. Molecular & general genetics : MGG 22 9065689
2017 Development and validation of InnoQuant® HY, a system for quantitation and quality assessment of total human and male DNA using high copy targets. Forensic science international. Genetics 21 28472756
2020 Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice. Biochemical and biophysical research communications 20 32081420
2008 The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Ea.hy 926 endothelial cells under long-term low folate stress is mediated by the p38 MAPK pathway. Atherosclerosis 20 19152916
2007 Biochemical and genetic characterization of arazyme, an extracellular metalloprotease produced from Serratia proteamaculans HY-3. Journal of microbiology and biotechnology 20 18051297
1993 Intracellular calcium signalling after binding of low-density lipoprotein to confluent and nonconfluent cultures of an endothelial cell line, EA.hy 926. Cell calcium 20 8395341
1984 H-Y antigen and the evolution of heterogamety. The Journal of heredity 19 6481129
2021 Novel Anti-Fungal d-Laminaripentaose-Releasing Endo-β-1,3-glucanase with a RICIN-like Domain from Cellulosimicrobium funkei HY-13. Biomolecules 18 34439747
2007 The effect of n-3 PUFA on eNOS activity and expression in Ea hy 926 cells. Prostaglandins, leukotrienes, and essential fatty acids 18 17229561
2002 Candida albicans expresses a focal adhesion kinase-like protein that undergoes increased tyrosine phosphorylation upon yeast cell adhesion to vitronectin and the EA.hy 926 human endothelial cell line. Infection and immunity 18 12065524
2007 Cell adhesion and integrin expression are modulated by oxidative stress in EA.hy 926 cells. Free radical research 17 17577742
1990 Modulation of hen granulosa cell steroidogenesis and plasminogen activator activity hy transforming growth factor alpha. Growth factors (Chur, Switzerland) 17 2173938
2010 The impact of anti-HY responses on outcome in current and subsequent pregnancies of patients with recurrent pregnancy losses. Journal of reproductive immunology 16 20307907
1990 Enrichment of bovine X- and Y-chromosome-bearing sperm with monoclonal H-Y antibody-fluorescence-activated cell sorter. Archives of andrology 16 2353847
1998 The serologically detected H-Y antigen revisited. Cytogenetics and cell genetics 15 9678364
1979 Ontogeny and localization of the crystallins during lens development in normal and Hy-1 (hyperplastic lens epithelium) chick embryos. Journal of embryology and experimental morphology 15 379264
2018 Subretinal Injection of HY Peptides Induces Systemic Antigen-Specific Inhibition of Effector CD4+ and CD8+ T-Cell Responses. Frontiers in immunology 14 29662488
2016 Inhibitory Effect of Lactococcus lactis HY 449 on Cariogenic Biofilm. Journal of microbiology and biotechnology 14 27435538
2015 Effect of γ-Aminobutyric Acid-producing Lactobacillus Strain on Laying Performance, Egg Quality and Serum Enzyme Activity in Hy-Line Brown Hens under Heat Stress. Asian-Australasian journal of animal sciences 14 26104406
1992 A molecular deletion map of the Y chromosome long arm defining X and autosomal homologous regions and the localisation of the HYA locus to the proximal region of the Yq euchromatin. Human molecular genetics 14 1301911
2023 Alleviation effect of conjugated linoleic acid on estradiol benzoate induced fatty liver hemorrhage syndrome in Hy-line male chickens. Journal of animal science 13 36751705
2015 Central administration of oxytocin differentially increases yawning, penile erections and scratching in high- (HY) and low-yawning (LY) sublines of Sprague-Dawley rats. Pharmacology, biochemistry, and behavior 13 25931266
2011 Anti-HY responses in pregnancy disorders. American journal of reproductive immunology (New York, N.Y. : 1989) 13 21726344
2006 Production of prostacyclin and prostaglandin E2 in resting and IL-1beta-stimulated A549, HUVEC and hybrid EA.HY 926 cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 13 17229988
1990 Carbohydrate and hydrophobic-carbohydrate recognition sites (CARS and HY-CARS) in solubilized glycosyltransferases. Indian journal of biochemistry & biophysics 13 2129345
2020 The adaptability of Hy-Line Brown laying hens to low-phosphorus diets supplemented with phytase. Poultry science 12 32616248
2013 Dombrock genotyping in Brazilian blood donors reveals different regional frequencies of the HY allele. Revista brasileira de hematologia e hemoterapia 12 24478605
1998 H-Y antigen expression patterns in human X- and Y-chromosome-bearing spermatozoa. American journal of reproductive immunology (New York, N.Y. : 1989) 12 9689360
2024 Curcumin blunts epithelial-mesenchymal transition to alleviate invasion and metastasis of prostate cancer through the JARID1D demethylation. Cancer cell international 11 39218854
1983 H-Y typing of karyotypically abnormal mice. Differentiation; research in biological diversity 11 6444167
2023 Baicalin mitigates nephropathogenic infectious bronchitis virus infection-induced spleen injury via modulation of mitophagy and macrophage polarization in Hy-Line chick. Veterinary microbiology 10 37866328
2018 Evaluation of InnoQuant® HY and InnoTyper® 21 kits in the DNA analysis of rootless hair samples. Forensic science international. Genetics 10 30578984
2024 KDM5D histone demethylase mediates p38α inactivation via its enzymatic activity to inhibit cancer progression. Proceedings of the National Academy of Sciences of the United States of America 9 39636854
2023 KDM5D Histone Demethylase Identifies Platinum-Tolerant Head and Neck Cancer Cells Vulnerable to Mitotic Catastrophe. International journal of molecular sciences 9 36982384
2021 Increased Mars2 expression upon microRNA-4661-5p-mediated KDM5D downregulation is correlated with malignant degree of gastric cancer cells. Cell biology international 9 34273914
1987 Mapping the H-Y gene. Development (Cambridge, England) 9 3503714

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